KR102678109B1 - Compositions Containing Bicell Structures - Google Patents

Abstract

The object of the present invention is to provide a bicell structure composition that can be safely and easily prepared without using an organic solvent, has excellent feeling of use (penetration, moisturizing feeling, elasticity) as an external skin preparation, and also has excellent storage stability. Do this.
The present invention includes the following components (a) to (e); (a) phospholipid, (b) cholesterol and/or phytosterol 0.02 to 1% by mass, (c) polyoxyethylene cholesteryl ether and/or polyoxyethylene phytosteryl ether with an average added mole number of ethylene oxide of 10 to 20. (d) at least one type of dihydric alcohol selected from propylene glycol, dipropylene glycol, and 1,3-butylene glycol, (e) water, and the component (a) ) and the content ratio (a)/(c) of component (c) is 0.4 to 2.0, and the content ratio of the sum of component (a) and component (c) to component (b) is {(a) + (c) }/(b) is a composition containing a bicell structure, characterized in that it is 5.0 or more.

Description

Compositions Containing Bicell Structures

The present invention relates to a composition containing a bicell structure using phospholipids, suitable for cosmetics or external skin preparations, and more specifically, to a composition containing a bicell structure using phospholipids, which is suitable for cosmetics or external skin preparations. The present invention relates to a composition that can be safely and easily prepared without the use of , has excellent feeling of use as an external skin preparation, and has excellent storage stability.

The bicell structure is a disk-shaped molecular assembly (Figure 1) in which the end of a double-layer flat membrane composed of long-chain phospholipids is covered with a surfactant such as short-chain phospholipids, with a minimum It is used in the study of biological membranes as a lipid bimolecular membrane model. For example, solubilizing the membrane protein in the bicell structure is effective in structural analysis of the membrane protein using NC (see Non-Patent Document 1). In addition, it is known that by applying the bicell structure, it penetrates into the stratum corneum of pig skin (see Non-Patent Document 2) or penetrates into the stratum corneum of a 3D cultured skin model and affects the lamellar structure of the stratum corneum. It is also attracting attention as a carrier.

As carriers applied to the skin, micelles, vesicles, etc. are already known.

A micelle is a colloid in which surfactants are combined, and is a thermodynamically stable equilibrium system that can contain a small amount of oil. Therefore, it is used when mixing lipophilic active ingredients in a low-viscosity cosmetic lotion-like formulation. However, because micelles contain only a small amount of emulsion, highly crystalline active ingredients such as cholesterol and phytosterol cannot be mixed stably, causing crystal precipitation over time. There was a case.

Vesicles are closed vesicles with a bimolecular membrane structure formed by amphipathic substances, but due to this specific structure, they can contain various active ingredients, and are also attracting attention as carriers in drug delivery systems, etc. (Patent Document 1) reference). In addition, when applied to the skin, vesicles have high retention in the stratum corneum, allowing active ingredients to act efficiently, making them effective as cosmetics or external skin preparations. Vesicles can stably contain cholesterol or phytosterols, but because the particle diameter is larger than that of bicell structures, permeability is poor and the moisturizing effect is sometimes insufficient.

Additionally, compositions containing existing bicell structures are generally prepared by the Bangham method. Specifically, the lipid is uniformly dissolved in an organic solvent such as chloroform, the organic solvent is removed using an evaporator to form a thin film, and water is added to disperse it (see Non-Patent Document 3). Preparations using the Bangham method are excellent for small scale preparations, but they are not suitable for mass production because the solvent needs to be removed once, and since organic solvents such as chloroform are used, they are not suitable for use in cosmetics or external skin preparations, etc. It is also undesirable as a method of preparing a composition.

Japanese Patent No. 5064717

Hirotaka S, SeketsuF, Jun K, Shigeyuki Y, Hiroshi H and Kazuo T. Langmuir, 19, 9841-9844 (2013) L.Barbosa-Barros, A.de la Maza, J.Estelrich, A.M.Linares, M.Feliz, P.Walther, R.Pons, and O.Lopez, Langmuir, 24, 5700-5706(2008) Oluwatosin A, Ogunsola Margaret E, Kraeling Sheng Zhong Darrin J, Pochan Robert L.Bronaughd and Srinivasa R.Raghavan, Soft Matter, 8, 10226-10232 (2012)

The present invention provides a bicell structure that can be safely and easily prepared without using an organic solvent, has excellent feeling of use (penetration, moisturizing feeling, elasticity the next morning) as a cosmetic or external skin preparation, and has excellent storage stability. The task is to provide a composition containing the present invention.

In this situation, as a result of intensive research by the present inventors, a surfactant having a specific structure was combined with phospholipid, cholesterol, and/or phytosterol in a specific ratio, and prepared using a specific dihydric alcohol and purified water to create a new surfactant. A cell structure was obtained, and a composition containing it was found to have excellent usability and storage stability, thereby completing the present invention.

That is, the present invention includes the following components (a) to (e);

(a) Phospholipids

(b) cholesterol and/or phytosterols

(c) at least one surfactant selected from polyoxyethylene cholesteryl ether and/or polyoxyethylene phytosteryl ether having an average added mole number of ethylene oxide of 10 to 20.

(d) At least one type of dihydric alcohol selected from propylene glycol, dipropylene glycol, and 1,3-butylene glycol

(e)water

Contains, the content ratio (a)/(c) of the component (a) and component (c) is 0.4 to 2.0, and the content mass ratio of the sum of component (a) and component (c) to component (b) It relates to a composition containing a bicell structure, wherein {(a)+(c)}/(b) is 5.0 or more.

In addition, the present invention relates to a composition containing the above-described bicell structure, which is a cosmetic or external preparation for skin. In addition, the present invention relates to a composition containing the above-mentioned bicell structure, which is a cosmetic or external preparation for the skin. In addition, the present invention provides a composition comprising dispersing component (a), component (b), and component (c) in component (d), and then dispersing component (e) and component (e). It relates to a method for producing a composition containing the bicell structure, which is prepared by mixing and stirring.

The composition containing the bicell structure of the present invention has excellent storage stability, has high penetration when applied to the skin, and has excellent moisturizing properties and excellent elasticity the next morning. Therefore, the composition of the present invention is useful as a cosmetic or external skin preparation, and can also provide very high transparency and aesthetic appeal in a lotion formulation.

Figure 1 is a schematic diagram of the bicell structure of the present invention.
Figure 2 is an electron micrograph (circumference ◎) of a composition containing the bicell structure of the present invention.
Figure 3 is an electron micrograph of a composition containing the bicell structure of the present invention.
Figure 4 is an electron micrograph of a composition containing a multilayer vesicle.

Hereinafter, the present invention will be described in detail. In addition, in this specification, the numerical range indicated using “~” means a range that includes the numerical values written before and after “~” as the lower limit and upper limit.

The composition containing the bicell structure of the present invention contains component (a) phospholipid. Component (a) Phospholipid is mainly used as a component of the bimolecular membrane structure in the bicell structure. The phospholipid of component (a) refers to a structure in which a fatty acid and phosphoric acid are bonded with glycerin or sphingosine as the central skeleton, and an alcohol is ester bonded to phosphoric acid. Fatty acids constituting phospholipids include saturated and unsaturated carboxylic acids having 7 to 22 carbon atoms, preferably 14 to 20 carbon atoms. Many alcohols that make up phospholipids contain nitrogen, and examples include choline, ethanolamine, inositol, and serine.

Component (a) of the present invention is not particularly limited as long as it is used in ordinary cosmetics or external skin preparations, and examples include soy phospholipids, hydrogenated soy phospholipids, egg yolk phospholipids, hydrogenated egg yolk phospholipids, sunflower phospholipids, and hydrogenated sunflower. Examples include phospholipids, and these can be used one or two or more types as needed, more preferably hydrogenated soy phospholipids and hydrogenated egg yolk phospholipids.

The content of component (a) in the present invention is not particularly limited, but is preferably 0.01 to 5% by mass (hereinafter, the unit is simplified to “%”), and more preferably 0.05 to 3%. Within this range, a composition with more excellent storage stability can be obtained.

The composition containing the bicell structure of the present invention contains component (b) cholesterol and/or phytosterol. By containing component (b), moisturizing effect and elasticity the next morning are improved, making the composition particularly useful as a cosmetic or external skin preparation. Component (b) is not particularly limited as long as it is used in cosmetics or external skin preparations, and may be used alone or in combination of two or more types as needed.

The content of component (b) in the present invention is 0.02 to 1%, and 0.05 to 0.5% is more preferable. If the content of component (b) is less than 0.02%, the moisturizing effect and elasticity the next morning are reduced, and if the content of component (b) exceeds 1%, crystal precipitation is likely to occur and storage stability deteriorates.

The composition containing the bicell structure of the present invention is component (c) at least one selected from polyoxyethylene cholesteryl ether and/or polyoxyethylene phytosteryl ether having an average added mole number of ethylene oxide of 10 to 20. Contains surfactants. Component (c) is mainly used as a component constituting the ends of the bicell structure, and contributes to the stability of the bicell structure by packing with component (a). The average added mole number of ethylene oxide of component (c) is 10 to 20, and if it is outside this range, a bicell structure is not formed. Among component (c), PO(10) cholesteryl ether, PO(10) phytosteryl ether, and PO(20) phytosteryl ether are preferable, and commercially available products thereof include EMF(10) cholesteryl ether, P(10) phytosteryl ether, and P(20) phytosteryl ether. Emulsion Co., Ltd. product), ＮＩＫＫＯＬ ＢPS-10, ＢPS-20 (Nippon Surfactant Industries CO., LTD.) product, etc., one type or two or more types as needed. Can be used in combination.

The content of component (c) in the present invention is not particularly limited, but is preferably 0.025 to 2.5%, and more preferably 0.05 to 2.5%. Within this range, a composition with excellent storage stability and excellent moisturizing feeling can be obtained.

In the composition containing the bicell structure of the present invention, the mass ratio (a)/(c) of component (a) and component (c) is 0.4 to 2, and the ratio of component (a) to component (b) is 0.4 to 2. The content ratio {(a)+(c)}/(b) of the total of component (c) is 5.0 or more. Outside this range, a bicell structure is not formed, or a composition that exhibits sufficient effects as a cosmetic or external skin preparation cannot be obtained.

The composition containing the bicell structure of the present invention contains component (d) at least one type of dihydric alcohol selected from propylene glycol, dipropylene glycol, and 1,3-butylene glycol. Component (d) is a solvent for dispersing component (a), component (b), and component (c) in water, and is a component for preparing a composition with excellent storage stability. These can be used one type or in combination of two or more types as needed.

The content of component (d) in the present invention is not particularly limited, but is preferably 1 to 40%, and more preferably 10 to 30%. This range is preferable because not only the storage stability of the composition containing the bicell structure but also its moisturizing effect is particularly excellent.

The composition containing the bicell structure of the present invention contains component (e). Component (e) water is used together with component (d) as a dispersion medium for the bicell structure. Component (e) is not particularly limited as long as it is used in cosmetics or external skin preparations. For example, in addition to purified water, hard water, soft water, natural water, tap water, seawater, deep sea water, electrolytic alkaline ionized water, Water such as electrolytic acid ionized water, ionized water, cluster water, or steam distilled water derived from plants such as lavender water, rose water, or orange flower water can be used. .

The content of component (e) in the present invention is not particularly limited, but is preferably approximately 50 to 99%.

In addition, the composition containing the bicell structure of the present invention includes optional ingredients that are mixed in ordinary cosmetics or external skin preparations, specifically, emulsions and alcohols, to the extent that they do not interfere with the effect of the present invention and the formation of the bicell structure. , powder, water-soluble polymer, film former, surfactant other than the above ingredients, oil-soluble gelling agent, organic modified clay mineral, resin, ultraviolet absorber, preservative, antibacterial agent, fragrance, antioxidant, pH regulator, chelating agent, etc. can be added. there is.

The composition containing the bicell structure of the present invention can be manufactured by various methods for producing conventional cosmetics or external skin preparations, but component (a), component (b), and component (c) are added to component (d). A method of preparing by dispersing and then mixing and stirring with component (e) is preferable because it is suitable for mass production. Specifically, for example, component (a), component (b), and component (c) are dispersed in component (d) heated to a temperature of preferably 70°C to 90°C, more preferably about 80°C, and For example, component (e) heated to a temperature of preferably about 70 to 90°C, more preferably about 80°C, is added to the solution, mixed and stirred, and then gradually cooled to room temperature. There are no particular restrictions on the method of stirring during preparation and cooling, but examples include dispersing equipment such as a disper mixer, homomixer, and bead mill, and high pressure processing equipment includes a microfluidizer ( microfluidizer), etc., but more preferably, their treatment can be performed under normal pressure.

As described above, a composition containing the bicell structure of the present invention is obtained, and the presence and particle size of the bicell structure can be confirmed by observation with a transmission electron microscope (Figure 2). The average particle diameter of the bicell structure of the present invention is preferably 10 to 60 nm in the long axis, more preferably 15 to 40 nm, and preferably 1 to 10 nm in the short axis. It is 3 to 8 nm. In the composition of the present invention, multilayer vesicle particles (concentric circular images of approximately 50 nm or more) may coexist, but more than half of the particles in the observation field are bicell structures (disk-shaped particles). If this is the case, the effect as a composition containing the bicell structure of the present invention is exhibited. That is, the ratio of the bicell structure in the present invention is expressed as (number of disk images/number of total particle images) in the field of view observed by an electron microscope, and is 50% or more, preferably 75%. % or more, and 100% is more preferable.

The composition containing the bicell structure of the present invention may be used as is as a cosmetic or external skin preparation, or after preparing the composition containing the bicell structure, it may be combined with other ingredients to be used as a cosmetic or external skin preparation, and can be used for various purposes. It can be used as a cosmetic or external skin preparation. For example, skin care cosmetics such as lotion, emulsion, cream, eye cream, beauty essence, massage material, pack material, hand cream, body lotion, body cream, cosmetics such as cosmetic base cosmetic, external solution, external gel, and cream. , ointment, liniment, lotion, patch, warning agent, spray, and aerosol. In addition, the method of use includes using with hands or fingers, and using by impregnating cotton, non-woven fabric, etc.

Example

The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto.

[Examples 1 to 13 and Comparative Examples 1 to 10: Essence]

Compositions shown in Tables 1 to 3 were prepared according to the following manufacturing method.

The bicell structure was confirmed by observation with a transmission electron microscope and evaluated according to the following criteria (FIGS. 2 and 3). Additionally, the transmittance (transparency) and storage stability of the composition were evaluated using the following evaluation methods. These compositions were applied to the skin (whole face) as a cosmetic liquid, and sensory evaluation was performed based on the following method. The evaluation results are shown in Tables 1 to 3.

(Manufacturing method)

1: Heat (A) to (D) to 80°C and disperse.

2: Heat section (E) to 80℃.

Add 2 to 3:1, mix and stir with a disper mixer.

4:3 was cooled to room temperature to obtain a cosmetic liquid (composition containing a bicell structure).

(Evaluation method 1: Confirmation of bicell structure)

The formation state of the bicell structure was observed using a transmission electron microscope. The disc-shaped phase unique to the bicell structure was judged using the following judgment criteria.

[Criteria]

(evaluation)

: (Judgment)

Many disk-shaped images are observed, and no images of multi-layer vesicles are visible (Figure 2).

: ◎

Slightly multilayered vesicles (concentric circles) are also observed (Figure 3).

: ○

Disc-shaped images are rarely observed (Figure 4)

: ×

(Evaluation method 2: Transmittance)

Regarding transparency immediately after production of the composition, the transmittance at a wavelength of 700 nm was measured using an ultraviolet/visible spectrophotometer. The measured transmittance was judged using the following judgment criteria.

[Criteria]

(Evaluation): (Judgment)

Transmittance over 90%: ◎

Transmittance 85% or more but less than 90%: ○

Transmittance above 80% and below 85%: △

Transmittance less than 80%: ×

(Evaluation Method 3: Storage Stability)

For each sample, those stored at a constant temperature of 40°C for 2 months were compared with those stored at 25°C for 2 months, and transparency and presence or absence of precipitates were visually evaluated and judged using the following judgment criteria.

[Criteria]

(Evaluation): (Judgment)

No change in appearance: ◎

Appearance appears slightly cloudy: ○

The appearance is clearly cloudy, or precipitates are identified: △

Appearance is noticeably cloudy, or precipitates are precipitated: ×

(Evaluation method 4: Sensory evaluation)

Twenty female panelists in their 20s to 40s were asked to use the composition containing the above-described bicell structure as a cosmetic liquid, and the following were evaluated regarding the feeling of use: (1) feeling of penetration, (2) feeling of moisturizing, and (3) feeling of elasticity the next morning. The evaluation was performed according to the following evaluation criteria. Additionally, the average of all panelists' ratings was calculated, and judgment was made using the following judgment criteria.

[Evaluation standard]

(Evaluation): (Rating)

Very felt: 5 points

Feel it slightly: 4 points

Average: 3 points

Doesn't feel right: 2 points

Can't feel it: 1 point

[Criteria]

(Average of all panel ratings): (Judgment)

Average score 4.5 or higher: ◎

Average score 3.5 or more but less than 4.5: ○

Average score above 2.5 but below 3.5: △

Average score less than 2.5: ×

As can clearly be seen from the results in Tables 1 to 3, Examples 1 to 13 had excellent storage stability, penetrated quickly when applied to the skin as a cosmetic liquid, and had an excellent moisturizing effect. In addition, the average particle diameter and ratio of the bicell structure according to electron microscope observation were 30 nm for the long axis and 3 to 5 nm for the short axis, and the ratio was 100% in Example 1, and 50 nm for the long axis and 3 to 5 nm for the short diameter, and the ratio was 100% in Example 6. It was %.

On the other hand, Comparative Examples 1 to 7, which did not contain component (c) or component (d), and Comparative Examples 8 to 10, where the mass ratio of each component was outside the range, did not form a bicell structure.

[Example 14: Toner]

(ingredient) (%)

1.Hydrogenated egg yolk phospholipid 0.1

2.ＰＯＥ(10)cholesterol ether 0.1

3. Phytosterol 0.01

4. Cholesterol 0.01

5.Dipropylene glycol 10.0

6. Remaining amount of purified water

7.Glycine 1.0

8.Theanine 1.0

9.Diglycerin 3.0

10.Ethanol 5.0

11. Proper amount of preservative

12. Proper amount of fragrance

(Manufacturing method)

A: Components (1) to (5) are dispersed by heating to 80°C.

B: Heat component (6) to 80°C.

C: Add A to B, mix and stir to form a bicell structure, and cool to room temperature.

D: Components (7) to (12) were added to C and mixed to obtain a lotion.

(result)

The lotion of Example 14 was a cosmetic with good storage stability, excellent penetration, and excellent moisturizing effect.

[Example 15: Emulsion]

(ingredient) (%)

1. Squalane 5.0

2.Decamethylcyclopentasiloxane 5.0

3. Polyoxyethylene (60) hydrogenated castor oil 2.0

4.Behenyl alcohol 0.5

6.1,3-Butylene glycol 7.0

7.Glycerin 5.0

8. Acrylic acid-alkyl methacrylate copolymer (Note 1) 0.2

9. Proper amount of preservative

10.Triethanolamine 0.2

11. Disodium edetate 0.02

12. Remaining amount of purified water

13. Proper amount of fragrance

14.Hydrogenated soy phospholipid 1.0

15.ＰＯＥ(10)cholesteryl ether 0.6

16.ＰＯＥ(20)cholesteryl ether 0.7

17.Hydrogenated lysophospholipid 0.1

18. Cholesterol 0.1

19.Dipropylene glycol 7.0

20.Purified water 10.0

(Note 1) Pemulen ＴＲ-2 (product of ＮＯＶＥＯＮ)

(Manufacturing method)

A: Components (1) to (7) are heated to 80°C and dissolved.

B: Components (8) to (12) are heated to 80°C, then added to A and emulsified.

C: Cool B to room temperature.

D: Components (14) to (19) are dispersed by heating to 80°C.

E: Component (20) is heated to 80°C, mixed and stirred while added to D to form a bicell structure.

F: After cooling E, it was added to C, and component (13) was further added to obtain an emulsion.

(result)

The emulsion of Example 15 was a cosmetic with good storage stability, excellent penetration, and excellent moisturizing effect.

[Example 16: Cream]

(ingredient) (%)

1. Hydrogenated soy phospholipid 2.0

2. Polyoxyethylene tristearate (20) sorbitan 3.0

3. Stearyl Alcohol 5.0

4.Liquid paraffin 10.0

5.Avocado oil 5.0

6.Vaseline 3.0

7.Sorbitol 10.0

8. Remaining amount of purified water

9.Ethanol 3.0

10. Proper amount of preservative

11. Appropriate amount of fragrance

12. Hydrogenated soy phospholipid 1.5

13.ＰＯＥ(10)phytosteryl ether 1.3

14. Phytosterol 0.4

15.Hydroxylated soy phospholipid 0.05

16. Propylene glycol 15.0

17. Purified water 10.0

(Manufacturing method)

A: Components (1) to (6) are heated to 70°C and dissolved.

B: Components (7) and (8) are heated to 70°C to dissolve and then added to A to emulsify.

C: After B is cooled to room temperature, components (9) to (11) are added.

D: Components (12) to (16) are dispersed by heating to 80°C.

E: Heat component (17) to 80°C, mix and stir while adding D to form a bicell structure.

F: After cooling E, it was added to C to obtain cream.

(result)

The cream of Example 16 was a cosmetic with good storage stability, excellent penetration, and excellent moisturizing effect.

[Example 17: Sheet-shaped cosmetic]

(ingredient) (%)

1.Hydrogenated sunflower phospholipid 0.05

2. Soy phospholipid 0.05

3.ＰＯＥ(10)cholesteryl ether 0.03

4.ＰＯＥ(20)phytosteryl ether 0.05

5. Cholesterol 0.02

6. Phytosterol 0.01

7.Astaxanthin 0.001

8.1,3-Butylene glycol 10.0

9. Remaining amount of purified water

10. Phenoxyethanol 1.0

11.Ethanol 5.0

12.Ascorbate glucoside 1.0

13. Sodium hyaluronate 0.2

14. Sodium hydroxide 0.13

(Manufacturing method)

A: Components (1) to (8) are dispersed by heating to 80°C.

B: Heat component (9) to 80°C, mix and stir while adding A to form a bicell structure.

C: After cooling B, components (10) to (14) are added and the nonwoven fabric is impregnated.

D:C was sealed and filled in an aluminum laminate pouch-shaped container to obtain a sheet-like cosmetic.

(result)

The sheet-like cosmetic of Example 17 had good storage stability, excellent penetration, and excellent moisturizing and whitening effects.

[Example 18: Creamy base cosmetic]

(ingredient) (%)

1. Zinc oxide (particle diameter 200 nm) 2.0

2. Dimethylpolysiloxane 25.0

3. PEG-9 polydimethylsiloxane ethyldimethicone 4.0

4.Isopropyl myristic acid 1.5

5. Acrylic-silicone graft copolymer mixture (Note 2) 2.0

6. Remaining amount of purified water

7.Ethanol 5.0

8. Propylene glycol 5.0

9.Silica powder 2.0

10. Proper amount of preservative

11. Proper amount of fragrance

12.Hydrogenated soy phospholipid 0.2

13.ＰＯＥ(5)phytosteryl ether 0.02

14.ＰＯＥ(10)phytosteryl ether 0.13

15. Cholesterol 0.1

16.Dipropylene glycol 2.0

17. Purified water 5.0

(Note 2) KP-549 (mixture of 60% acrylic-silicone graft copolymer and 40% methyltrimethicone) (Shin-Etsu Chemical Co., Ltd.)

(Manufacturing method)

A: Components (1) to (5) are dispersed using three roll mills.

B: Mix components (6) to (11).

C: Add A to B to emulsify.

D: Components (12) to (16) are dispersed by heating to 80°C.

E: Component (17) is heated to 80°C, mixed and stirred while adding D to form a bicell structure.

F: After cooling E, it was added to C to obtain a creamy base cosmetic.

(result)

The creamy base cosmetic of Example 18 had good storage stability, excellent penetration, and excellent moisturizing effect.

[Example 19: Toner]

(ingredient) (%)

1. Hydrogenated egg yolk phospholipid 0.65

2.ＰＯＥ(10)cholesteryl ether 1.2

3. Cholesterol 0.15

4.1,3-Butylene glycol 20.0

5. Remaining amount of purified water

6.Niacinamide 0.5

7. Proper amount of preservative

8. Proper amount of fragrance

(Manufacturing method)

A: Components (1) to (4) are dispersed by heating to 80°C.

B: Heat component (5) to 80°C.

C: Add A to B, mix and stir to form a bicell structure, and cool to room temperature.

D: Components (6) to (8) were added to C and mixed to obtain a lotion.

(result)

The bicell structure of Example 19 had an average particle diameter of 15 nm for the long axis and 3 to 5 nm for the minor axis according to electron microscope observation, and the ratio of the bicell structure was 100%. In addition, the lotion of Example 19 was a cosmetic with good storage stability, excellent penetration, and excellent moisturizing effect.

Claims (5)

The following components (a) to (e);
(a) Phospholipids
(b) Cholesterol and/or phytosterol 0.02 to 1% by mass
(c) at least one surfactant selected from polyoxyethylene cholesteryl ether and/or polyoxyethylene phytosteryl ether having an average added mole number of ethylene oxide of 10 to 20.
(d) At least one type of dihydric alcohol selected from propylene glycol, dipropylene glycol, and 1,3-butylene glycol
(e)water
Contains, the content ratio (a)/(c) of the component (a) and component (c) is 0.4 to 2.0, and the content mass ratio of the sum of component (a) and component (c) to component (b) A composition containing a bicell structure, wherein {(a)+(c)}/(b) is 5.0 or more.
According to paragraph 1,
A composition containing a bicell structure, wherein the content of component (a) is 0.01 to 5% by mass.
According to paragraph 1 or 2.
A composition containing a bicell structure, characterized in that the content of component (c) is 0.025 to 2.5 mass%.
According to paragraph 1,
A composition containing a bicell structure, which is a cosmetic or external skin preparation.
The bicell structure of claim 1, which is prepared by dispersing the component (a), the component (b), and the component (c) in the component (d) and then mixing and stirring the component (e). Method for producing a composition containing.