KR102618447B1 - Chemical Exposure Assessment System Using Lung Mock-Up - Google Patents

Abstract

A chemical exposure assessment system using a mock-up of a lung is launched. The chemical exposure assessment system according to an embodiment of the present invention is a lung model produced from the nasal cavity and oral cavity to the end of the lung bronchioles using a 3D printing technique based on a CT photograph of the lungs of a body with a body structure corresponding to that of an average Korean adult male. ; A particle detection unit mounted on the intake and exhaust ports of the waste model unit to detect the amount of chemicals in the air flowing in from the waste model unit and the amount of chemicals in the air discharged from the waste model unit; an intake port unit that is mounted in a structure that communicates with the outlet of the lung model unit and generates air flow by forming a negative pressure from the intake port of the waste model unit to the exhaust port; and a monitoring unit that calculates and outputs the lung deposition rate or absorption rate in the lungs of the inhaled chemical particles based on the data obtained from the particle detection unit.
According to the present invention, it is possible to provide a chemical exposure assessment system that can quantitatively calculate the amount of human exposure in real time when exposed to various household chemical products in the air, such as humidifier sterilizers, disinfectants, detergents, and mosquito coils.

Description

Chemical Exposure Assessment System Using Lung Mock-Up}

The present invention relates to a chemical exposure assessment system, and more specifically to a chemical exposure assessment system G using a physical model of a waste.

The humidifier disinfectant incident, which has been on the surface since 2011, is an incident in which people have contracted diseases such as lung disease or died due to humidifier disinfectant contained in the spray liquid (mist) of humidifiers.

According to the statistics of the Special Investigation Committee on Social Disasters as of July 17, 2020, 6,817 people reported damage to the Ministry of Environment, of which 1,553 died, the number of unidentified death victims is estimated at 14,000, and those who experienced health damage It is reported that the number will reach 670,000.

As a result, public concern and interest in the harmfulness of household chemical products have increased, and verification of the safety of household chemical products has become very important, and the government is also actively managing them, but there are still risk factors in the living environment. A variety of household chemical products are used.

Microscopic particles penetrate deep into the human lungs, and the reason why the humidifier disinfectant incident caused so much damage is because the liquid containing the disinfectant was dispersed into the air in the form of a microscopic aerosol (mist).

When inhaling particles in the air, the effects on the human body may vary depending on the area where the particles are deposited in the respiratory tract. In particular, the alveoli, which are the final end of the respiratory tract, have weak defense mechanisms, and particles move throughout the body along the blood vessels in the oxygen and carbon dioxide gas exchange area, causing damage outside the respiratory tract. Since toxicity can occur in other areas as well, special care must be taken with particles that reach the alveoli.

The main factor affecting the deposition site of particles in the respiratory tract is the size of the particles. The smaller the particle size, the deeper it reaches the respiratory tract. Therefore, identifying the size distribution of particles distributed in the air is very important in health risk assessment.

Meanwhile, unlike particles, gaseous substances can partially dissolve in the upper respiratory tract (mucosa), so the amount reaching deep into the respiratory tract is expected to be relatively small compared to particles, but specific research on this is lacking.

A variety of household chemical products have been developed and released, including humidifier disinfectants, various sprays, and various misting products such as mosquito coils. However, related laws and regulations related to safety evaluation only limit the content of hazardous substances in household chemical products themselves, and household chemical products are Research on human exposure assessment when used in actual living environments and research on lung deposition and deposition area when inhaled and exposed to various types of household chemical products are very lacking.

To solve this problem, the device shown in Figure 1 was developed. The device according to the prior art shown in FIG. 1 is an exposure and risk assessment device for household chemical products and can evaluate the risk of chemicals floating in the air.

However, the device shown in FIG. 1 is a device that simply inhales and analyzes chemicals floating in the air, and cannot accurately analyze the amount of human exposure actually inhaled into the lungs of the human body.

Therefore, there is a need for a technology that can solve the problems caused by the prior art mentioned above.

Korean Patent Publication No. 10-1905966 (Registration date: October 1, 2018)

The purpose of the present invention is to provide a chemical exposure assessment system that can quantitatively calculate human exposure in real time when exposed to various household chemical products in the air, such as humidifier sterilizers, disinfectants, detergents, and mosquito coils.

To achieve this purpose, the chemical exposure assessment system according to one aspect of the present invention is a 3D printing technique based on a CT photograph of the lungs of a body with a body structure corresponding to that of an average Korean adult male, from the nasal cavity and oral cavity to the terminal lung bronchioles. Lung models produced up to; A particle detection unit mounted on the intake and exhaust ports of the waste model unit to detect the amount of chemicals in the air flowing in from the waste model unit and the amount of chemicals in the air discharged from the waste model unit; an intake port unit that is mounted in a structure that communicates with the outlet of the lung model unit and generates air flow by forming a negative pressure from the intake port of the waste model unit to the exhaust port; and a monitoring unit that calculates and outputs the lung deposition rate or absorption rate of the inhaled chemical particles based on the data obtained from the particle detection unit.

In one embodiment of the present invention, the lung model unit includes a first step of generating a 3D model of the bronchial tubes using the Lung4cer model generator, an algorithm-based program for generating various types of bronchial and alveolar models; The second step is to check the extracted 3D modeling data, make the first correction, check the quarterly holes, and set the thickness required for assembly; A third step of converting data into 3D printer data and performing 3D printing; and a fourth step of assembling the 3D printed lung model.

In one embodiment of the present invention, the lung model unit is a structure in which the nasal cavity shape and the oral cavity shape of the body are created as an integrated structure, the openings exposed to the outside are formed independently on the nasal cavity side and the oral cavity side, and the bronchial formation portion is formed. An intake port with a detachable structure from the top; a bronchial formation unit, which has a structure that communicates with the intake port, has a structure shaped like a body's bronchial tube, and has a piping structure that delivers air sucked from the intake port to the alveolar formation unit through the first and second branch pipes; It is mounted in a structure that communicates with one end of the bronchial formation, has a structure that creates the shape of alveoli in the body, is a piping structure through which air delivered from the bronchial formation is transmitted, and has a through hole formed at one end of the alveolar formation; An independently separated space is formed in each of the first and second branch organs of the bronchial formation, and the lung shell is formed in a structure that surrounds the alveolar formation to form a closed space, and is made of a material having a rigidity of a predetermined size. housing; And a plurality of units are mounted at regular intervals on the outer peripheral surface of the closed shell housing, and the interior of the closed shell housing and the intake port part communicate with each other, and the air inside the closed shell housing is discharged through the exhaust tube by the operation of the intake port eastern part. It may be configured to include an exhaust port configured to exhaust air.

In one embodiment of the present invention, the lung model unit is mounted on the inner surface of the nasal cavity of the intake port, and exposes an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port by an electrical signal provided from the monitoring unit to expose the surface. A first mucosal portion with a flexible thin plate structure that changes the degree of adhesion; A second mucosal portion of a flexible thin plate structure that is mounted on the inner surface of the bronchial formation and changes the degree of adhesion of the surface by exposing an adhesive material to the surface exposed to the inner space of the intake nasal cavity by an electrical signal provided from the monitoring unit; A third mucosal portion of a flexible thin plate structure that is mounted on the inner surface of the alveolar forming portion and changes the degree of adhesion of the surface by exposing an adhesive material to the surface exposed to the inner space of the air intake nasal cavity by an electrical signal provided from the monitoring unit; and an opening control unit that is mounted on each of the exhaust ports to operate independently and has a structure that adjusts the degree of opening based on a signal provided from the monitoring unit.

In one embodiment of the present invention, the intake unit has a structure that communicates with one end of a pipe that is discharged to the outside through the exhaust port, is mounted on one side of the monitoring unit, and purifies the air delivered through the exhaust port and discharges it to the outside. It may be a configuration that includes an exhaust purification unit having a structure that:

In this case, the exhaust purification unit includes a mounting frame of a closed box structure, which is mounted on one side of the monitoring unit and has a lower filter unit installed at the bottom that sucks air delivered from the exhaust port, and an upper filter unit installed at the top; a lower filter unit mounted at the bottom of the mounting frame, having a detachable structure, and having a structure to filter particulate matter floating in the air delivered from the exhaust port; A central filter unit mounted on the top of the lower filter unit and having a structure that disinfects by spraying a disinfectant mist while forming a rotating vortex in the air delivered through the lower filter unit; and an upper filter unit mounted at the top of the central filter unit and sterilizing the air by irradiating UV-C to the air delivered through the central filter unit.

In one embodiment of the present invention, the central filter unit is mounted between the lower filter unit and the upper filter unit and has a hollow cylinder structure extending in the direction of the lower filter unit and the upper filter unit, and air passing through the lower filter unit A rotating cylinder that rotates to flow to the upper filter and at the same time form a rotating vortex; A rotating support cylinder having a hollow cylindrical structure surrounding the rotating cylinder and mounting the rotating cylinder therein so as to be rotatable; A plurality of rotating protrusions are formed on the outer peripheral surface of the rotating cylinder at regular intervals and rotate the rotating cylinder by the pressing force of the disinfectant mist injected between the rotating cylinder and the rotating support container; A plurality of holes are formed at regular intervals on the outer peripheral surface of the rotary cylinder, and are formed adjacent to the disinfectant mist receiving surface of the rotary protrusion, and are internal spray penetrations that allow the disinfectant mist injected between the rotary cylinder and the rotary support cylinder to flow into the internal hollow space. nine; and an injection nozzle that is mounted on the upper part of the exhaust purification unit and injects the disinfectant mist provided from the outside into the rotating support cylinder of the rotating cylinder with a predetermined amount of pressure.

In one embodiment of the present invention, the exhaust purification unit is mounted on the upper surface of the other side of the mounting frame, has a structure that opens or closes the internal storage space to the outside, and is open to the outside so that the exhaust purification unit can be taken out. Filter discharge opening and closing part of; A lower rail mounted on the inner side of the mounting frame, having a structure to support both sides of the lower filter unit, and having a structure to support the lower filter unit so that its sliding position can be changed through the filter discharge opening and closing part; A central rail mounted on the inner side of the mounting frame and supporting both sides of the central filter unit, the central rail having a structure that supports the central filter unit so that its sliding position can be changed through the filter discharge opening and closing part; and an upper rail mounted on the inner side of the mounting frame, having a structure to support both sides of the upper filter part, and supporting the upper filter part so that its sliding position can be changed through the filter discharge opening and closing part.

As described above, according to the chemical exposure assessment system of the present invention, by providing a lung model part, particle detection part, suction inlet part, and monitoring part of a specific structure, various household chemical products such as humidifier sterilizers, disinfectants, detergents, and mosquito coils are released into the air. It is possible to provide a chemical exposure assessment system that can quantitatively calculate the amount of human exposure in real time when exposed to .

In addition, according to the chemical exposure assessment system of the present invention, by providing a first mucosal portion, a second mucosal portion, a third mucosal portion, and an opening control portion of a specific structure, the body suffering from a respiratory disease such as a cold or in an extreme environment It is possible to provide a chemical exposure assessment system that can quantitatively calculate human exposure in real time even for bodies placed in the environment.

In addition, according to the chemical exposure assessment system of the present invention, by providing an exhaust purification unit with a specific structure, it is possible to prevent harmful chemicals generated during the experiment from scattering into the laboratory air, thereby ensuring the health of the experimenter and the laboratory. We can provide a chemical exposure assessment system that can ensure a safe internal environment.

Figure 1 is a configuration diagram showing an exposure and risk assessment device for household chemical products according to the prior art.
Figure 2 is a photograph showing a chemical exposure assessment system according to an embodiment of the present invention.
Figure 3 is a photograph showing the waste model portion of the chemical exposure assessment system shown in Figure 2.
Figure 4 is a photograph showing the internal structure of the lung model shown in Figure 3.
Figure 5 is a front view showing the waste model portion of the chemical exposure assessment system according to an embodiment of the present invention.
Figure 6 is a front view showing the closed outer shell housing of the closed model shown in Figure 5.
Figure 7 is a photograph showing the creation of a 3D model of the bronchial tubes in the process of manufacturing a lung model according to an embodiment of the present invention.
Figure 8 is a photograph showing the creation of a 3D model of the bronchial tubes in the process of manufacturing a lung model according to an embodiment of the present invention.
Figure 9 is a photograph showing the creation of a 3D model of the bronchus in the process of manufacturing a lung model according to an embodiment of the present invention.
Figure 10 is a photograph showing that in the process of manufacturing a lung model according to an embodiment of the present invention, the bronchial 3D model is first corrected, checked for quarterly holes, set to the thickness required for assembly, and converted into data for a 3D printer. am.
Figure 11 is a photograph showing the 3D printing process using 3D printer data and the alveolar formation portion of the completed lung model portion.
Figure 12 is a front view showing an exhaust purification unit according to an embodiment of the present invention.
Figure 13 is a front schematic diagram showing the internal structure of the exhaust purification unit shown in Figure 12.
Figure 14 is an enlarged view of part B of Figure 13.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. Prior to this, terms and words used in this specification and claims should not be construed as limited to their usual or dictionary meanings, but should be construed with meanings and concepts consistent with the technical idea of the present invention.

Throughout this specification, when a member is said to be located “on” another member, this includes not only cases where a member is in contact with another member, but also cases where another member exists between the two members. Throughout this specification, when a part "includes" a certain component, this means that it may further include other components rather than excluding other components, unless specifically stated to the contrary.

In Korea, a variety of household chemical products have been developed and released, including humidifier disinfectants, various sprays, and various misting products such as mosquito coils. However, related laws and regulations related to safety evaluation only limit the content of hazardous substances in household chemical products themselves, and household chemical products Research on human exposure assessment when products are used in actual living environments and research on lung deposition and deposition sites when inhaled and exposed to various types of household chemical products are very lacking.

The present invention produces a life-sized lung model using a 3D printing technique based on a lung CT photo of a person with a height of 174 cm, corresponding to the average Korean adult male, and measures the number and concentration of particles by size in real time on the produced lung model to detect chemical substances. It can be applied to the field of human risk assessment research due to exposure.

The main factor affecting the deposition site of particles in the respiratory tract is the size of the particles. The smaller the particle size, the deeper it reaches the respiratory tract. Therefore, identifying the size distribution of particles distributed in the air is very important in health risk assessment.

Meanwhile, unlike particles, gaseous substances can partially dissolve in the upper respiratory tract (mucosa), so the amount reaching deep into the respiratory tract is expected to be relatively small compared to particles, but specific research on this is lacking.

Therefore, through the present invention, it is designed to measure exposure in the lungs in real time (from seconds to minutes), making it possible to conduct in-depth human risk assessment research.

The present invention uses a 3D printing technique to accurately model the nasal cavity and oral cavity to the 11 branches (about 1 mm in diameter) at the end of the lung bronchioles, which can be manufactured with current technology, based on a lung CT photo of a person with a height of 174 cm, corresponding to the average Korean adult male. After manufacturing, two SMPS (OPS), a particle measuring instrument that measures the concentration of particles in the air by size in real time, ranging from very small ultra-fine particles to fine particles (10㎚ to 10㎛), are used, one of which is used to measure the model's larynx. It was designed to calculate the deposition rate of aspirated particles in the lung by simultaneously measuring it in real time by connecting it to a location, and the other device to a location before reaching the suction pump after going through the lung model.

At the same time, the PTR TOF MS, which measures the type and concentration of VOCs in the air in real time, is connected to the larynx and the location after passing through the lung model, similar to the SMPS above, and the deposition rate (absorption rate) of inhaled VOCs in the lung is also calculated. It was designed to do so.

In addition, experimental results can be checked in real time through the device displays of Equipment 1 and Equipment 2, and data stored in the equipment can be backed up and used separately for statistical analysis, modeling, etc. In addition, the human respiratory system extends into 11 branches starting from the larynx/nasal cavity to the bronchi, small bronchi, and bronchioles. When assembling a lung model, by changing each branch and experimenting, it is possible to evaluate where particles and gases are deposited in the lungs.

Through this, it was possible to quantitatively calculate the amount of human exposure in real time when exposed to various household chemical products in the air, such as humidifier sterilizers, disinfectants, detergents, and mosquito coils. Even if the same household chemical product is used, the amount of chemical substances deposited in the lungs will vary depending on variables such as usage amount, method of use (near-distance spray, long-distance exposure), and characteristics of space and environment (size, temperature and humidity, wind speed, etc.). Since the properties of chemicals in the air change depending on the time after product use, the amount deposited in the lungs will change. In-depth human risk assessment research was designed to measure exposure in the lungs in real time (seconds to minutes). It was designed to make it possible

Figure 2 shows a photograph showing a chemical exposure evaluation system according to an embodiment of the present invention, Figure 3 shows a photograph showing a waste model portion of the chemical exposure evaluation system shown in Figure 2, and Figure 4 A photograph showing the internal structure of the closed model shown in FIG. 3 is shown.

Referring to these drawings, the chemical exposure assessment system 100 according to this embodiment is provided with a lung model unit 110, a particle detection unit 120, an inlet unit 130, and a monitoring unit 140 of a specific structure. , it is possible to provide a chemical exposure assessment system that can quantitatively calculate the amount of human exposure in real time when exposed to various household chemical products in the air, such as humidifier sterilizers, disinfectants, detergents, and mosquito coils.

Hereinafter, each component constituting the chemical exposure assessment system 100 according to this embodiment will be described in detail with reference to the drawings.

Figure 5 shows a front view showing the waste model portion of the chemical exposure assessment system according to an embodiment of the present invention, and Figure 6 shows a front view showing the waste shell housing of the waste model part shown in Figure 5.

Referring to Figures 2 to 6, the lung model unit 110 according to this embodiment is manufactured from the nasal cavity and oral cavity to the lung bronchioles using a 3D printing technique based on a CT photograph of the lungs of a body with a body structure corresponding to that of an average Korean adult male. Manufactured to the very end.

The particle detection unit 120 according to this embodiment is mounted on the intake port 111 and the exhaust port 115 of the waste model unit 110 and measures the amount of chemicals in the air flowing in from the waste model unit 110 and the waste model unit 110. The amount of chemicals in the air emitted from the device can be detected.

The intake port 130 according to this embodiment is mounted in a structure that communicates with the outlet of the lung model unit 110, and creates a negative pressure from the intake port 111 of the lung model unit 110 to the exhaust port 115 to prevent air flow. can be created.

The monitoring unit 140 according to this embodiment can calculate and output the deposition rate or absorption rate within the lungs of the aspirated chemical particles based on the data acquired from the particle detection unit 120.

Figure 7 shows a photograph showing the creation of a 3D model of the bronchi in the process of manufacturing a lung model according to an embodiment of the present invention, and Figure 8 shows a photo showing the process of producing a lung model according to an embodiment of the present invention. A photograph showing the creation of a 3D model of the bronchial tubes in the process is shown, and Figure 9 shows a photograph showing the creation of a 3D model of the bronchial tubes in the process of manufacturing a lung model according to an embodiment of the present invention. there is. In addition, Figure 10 shows that in the process of manufacturing a lung model according to an embodiment of the present invention, the bronchial 3D model is first corrected, quarterly holes are checked, and the thickness required for assembly is set and converted into data for a 3D printer. A photo is shown, and FIG. 11 shows a photo showing the 3D printing process using 3D printer data and the alveolar formation area of the completed lung model.

Referring to these drawings, the waste model unit 110 according to this embodiment is manufactured by performing multiple processes. Specifically, the first step of creating a bronchial 3D model is performed using the Lung4cer model generator, an algorithm-based program for creating various types of bronchial and alveolar models. Afterwards, the second step is performed to check the extracted 3D modeling data, make the first correction, check the quarterly holes, and set the thickness required for assembly. Afterwards, the third step of converting the data into 3D printer data and performing 3D printing is performed, and then the fourth step of assembling the 3D printed lung model is performed.

As shown in Figures 3 to 6, the lung model unit 110 according to this embodiment includes an intake port 111, a bronchial formation unit 112, an alveolar formation unit 113, and a lung shell housing 114 of a specific structure. ) and an exhaust port 115.

Specifically, the intake port 111 of the lung model unit 110 is a structure in which the nasal cavity shape and the oral cavity shape of the body are created as an integrated structure, and the openings exposed to the outside are formed independently on the nasal cavity side and the oral cavity side, forming bronchial tubes. It is a structure that is detachable from the top of the part 112. The bronchial formation unit 112 is a structure that communicates with the intake port 111 and is a structure that creates the shape of a body's bronchial tube, and directs the air sucked in from the intake port 111 to the alveolar formation unit through the first and second branch pipes. It is a piping structure that delivers to (113). The alveolar forming part 113 is mounted in a structure that communicates with one end of the bronchial forming part 112, is a structure that creates the shape of the alveoli of the body, and is a piping structure through which air delivered from the bronchial forming part is transmitted, and penetrates one end. A sphere is formed. The lung outer shell housing 114 forms independently separate spaces in each of the first and second branch organs of the bronchial formation unit 112, and is formed in a structure that surrounds the alveolar formation unit 113 to create a closed space. It is formed and is made of a material that has a certain amount of rigidity. In addition, a plurality of exhaust ports 115 are mounted on the outer peripheral surface of the closed shell housing 114 at regular intervals, and have a structure that communicates between the inside of the closed shell housing 114 and the intake port 130, and the intake port 130 It is a structure that exhausts the air inside the closed shell housing 114 to the intake port 130 through the exhaust tube 116 by the operation of .

In some cases, the lung model unit 110 according to the present embodiment may include a first mucosal portion (not shown), a second mucosal portion (not shown), a third mucosal portion (not shown), and an open mucosal portion (not shown) of a specific structure. It may be configured to further include an adjustment unit (not shown).

Specifically, the first mucosal portion is mounted on the inner surface of the nasal cavity of the intake port 111, and exposes an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electrical signal provided from the monitoring unit 140. It is a flexible thin plate structure that changes the degree of adhesion. The second mucosal portion is mounted on the inner surface of the bronchial formation portion 112, and exposes an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electrical signal provided from the monitoring unit 140 to determine the degree of adhesiveness of the surface. It is a flexible thin plate structure that changes. The third mucosal portion is mounted on the inner surface of the alveolar forming portion 113, and exposes an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electrical signal provided from the monitoring unit 140 to determine the degree of adhesiveness of the surface. It is a flexible thin plate structure that changes. In addition, the opening control units are mounted on the exhaust ports 115 to operate independently, and have a structure that adjusts the degree of opening by a signal provided from the monitoring unit 140.

In this case, according to this embodiment, by providing a first mucosal portion, a second mucosal portion, a third mucosal portion, and an opening control portion of a specific structure, it can be used for a body suffering from a respiratory disease such as a cold or a body in an extreme environment. It is possible to provide a chemical exposure assessment system that can quantitatively calculate human exposure in real time.

FIG. 12 shows a front view showing an exhaust purification unit according to an embodiment of the present invention, FIG. 13 shows a front schematic diagram showing the internal structure of the exhaust purification unit shown in FIG. 12, and FIG. 14 shows B of FIG. 13. A partial enlarged view is shown.

Referring to these drawings, the chemical exposure assessment system 100 according to this embodiment may further include an exhaust purification unit 150.

Specifically, the exhaust purification unit 150 has a structure that communicates with one end of the pipe that is exhausted to the outside through the exhaust port 115, is mounted on one side of the monitoring unit 140, and purifies the air delivered through the exhaust port 115. It is a structure that discharges to the outside.

The exhaust purification unit 150 may include a mounting frame 151, a lower filter unit 152, a central filter unit 153, and an upper filter unit 154 of a specific structure.

The mounting frame 151 of the exhaust purification unit 150 is mounted on one side of the monitoring unit 140, and has a lower filter unit 152 mounted at the bottom that intakes air delivered from the exhaust port 115, and at the top. It is a closed box structure equipped with an upper filter unit (154). The lower filter unit 152 is mounted at the bottom of the mounting frame 151, has a detachable structure, and has a structure that filters particulate matter floating in the air delivered from the exhaust port 115. The central filter unit 153 is a component mounted on the top of the lower filter unit 152, and has a structure that forms a rotating vortex in the air delivered from the lower filter unit 152 and disinfects it by spraying a disinfectant mist at the same time. . In addition, the upper filter unit 154 is mounted on the top of the central filter unit 153 and has a structure that sterilizes the air by irradiating UV-C to the air delivered through the central filter unit 153.

As shown in Figures 13 and 14, the central filter unit 153 according to the present embodiment includes a rotating cylinder 154a, a rotating support cylinder 154b, a rotating protrusion 154c, and an inner injection through hole of a specific structure. It may be configured to include (154d) and an injection nozzle (154e).

Specifically, the rotating cylinder 154a of the central filter unit 153 is mounted between the lower filter unit 152 and the upper filter unit 154, and extends in the direction of the lower filter unit 152 and the upper filter unit 154. It has a hollow cylinder structure and rotates to flow the air that has passed through the lower filter unit 152 to the upper filter unit 154 and at the same time form a rotating vortex. The rotation support cylinder 154b is a hollow cylindrical structure surrounding the rotation cylinder 154a, and has a structure in which the rotation cylinder 154a is rotatably mounted therein. A plurality of rotating protrusions 154c are formed on the outer peripheral surface of the rotating cylinder 154a at regular intervals, and the rotating cylinder 154a is moved by the pressing force of the disinfectant mist injected between the rotating cylinder 154a and the rotating support container 154b. It is a rotating structure. A plurality of inner injection through-holes 154d are formed at regular intervals on the outer peripheral surface of the rotating cylinder 154a, and are formed adjacent to the disinfectant mist receiving surface of the rotating protrusion 154c, and are formed adjacent to the rotating cylinder 154a and the rotating support cylinder. It is a structure that allows the disinfectant mist injected between (154b) to flow into the internal hollow space. In addition, the injection nozzle 154e is mounted on the upper part of the exhaust purification unit 150 and has a structure that injects the disinfectant mist provided from the outside into the rotating support cylinder 154b of the rotating cylinder 154a with a predetermined amount of pressure.

In some cases, as shown in FIG. 12, the exhaust purification unit 150 according to the present embodiment includes a filter discharge opening and closing portion 115a, a lower rail 115b, a central rail 115c, and an upper rail 115d of a specific structure. It may be a configuration that includes.

Specifically, the filter discharge opening/closing unit 115a is mounted on the upper surface of the other side of the mounting frame 151, has a structure that opens or closes the internal storage space to the outside, and is open to the outside to extract the exhaust purification unit 150. It is a structure. The lower rail (115b) is mounted on the inner side of the mounting frame 151 and has a structure that supports both sides of the lower filter unit 152, and changes the position of the lower filter unit 152 by sliding it through the filter discharge opening and closing unit 115a. It is a structure that supports this. The central rail (115c) is mounted on the inner side of the mounting frame 151 and has a structure that supports both sides of the central filter unit 153, and changes the position of the central filter unit 153 by sliding it through the filter discharge opening and closing unit 115a. It is a structure that supports this. In addition, the upper rail 115d is mounted on the inner side of the mounting frame 151 and has a structure that supports both sides of the upper filter unit 154, and slides the upper filter unit 154 through the filter discharge opening and closing unit 115a. It is a support structure that allows the position to be changed.

In this case, according to this embodiment, by providing an exhaust purification unit of a specific structure, it is possible to prevent harmful chemicals generated during the experiment from scattering into the laboratory air, thereby ensuring the health of the experimenter and creating a safe environment inside the laboratory. We can provide a chemical exposure assessment system that can guarantee

In the above detailed description of the present invention, only special embodiments thereof have been described. However, it should be understood that the present invention is not limited to the particular form mentioned in the detailed description, but rather is understood to include all modifications, equivalents and substitutes within the spirit and scope of the present invention as defined by the appended claims. It has to be.

That is, the present invention is not limited to the specific embodiments and descriptions described above, and various modifications may be made by anyone skilled in the art without departing from the gist of the present invention as claimed in the claims. is possible, and such modifications fall within the scope of protection of the present invention.

100: Chemical exposure assessment system
110: Lung model unit
111: intake port
112: Bronchial formation
112a: First branch organ
112b: Branch 2 organ
113: Alveolar formation
114: Closed shell housing
115: exhaust port
115a: Filter discharge opening and closing part
115b: Lower rail
115c: Central rail
115d: upper rail
116: exhaust tube
120: particle detection unit
121: First particle detection unit
122: Second particle detection unit
130: Eastern part of intake
140: Monitoring unit
150: Exhaust purification unit
151: Mounting frame
152: Lower filter unit
153: Central filter unit
154: Upper filter part
154a: Rotating cylinder
154b: Rotating support container
154c: Rotating protrusion
154d: Internal injection through-hole
154e: Injection nozzle
154f: Bearing

Claims (7)

A lung model unit (110) produced from the nasal cavity and oral cavity to the end of the lung bronchioles using a 3D printing technique based on a CT photograph of the body's lungs;
It is mounted on the intake port 111 and the exhaust port 115 of the lung model unit 110 to detect the amount of chemicals in the air flowing in from the waste model unit 110 and the amount of chemicals in the air discharged from the waste model unit 110. a particle detection unit 120;
An intake port 130 that is mounted in a structure that communicates with the outlet of the lung model unit 110 and generates air flow by forming negative pressure from the intake port 111 of the lung model unit 110 to the exhaust port 115; and
a monitoring unit 140 that calculates and outputs the lung deposition rate or absorption rate of the inhaled chemical particles based on the data obtained from the particle detection unit 120;
Including,
The lung model unit 110,
It is a structure in which the nasal cavity shape and the oral cavity shape of the body are created as an integrated structure, and the openings exposed to the outside are formed independently on the nasal cavity side and the oral cavity side, and the intake port 111 has a structure that is detachable from the upper end of the bronchial formation portion 112. ;
It is a structure that communicates with the intake port 111, has a structure that creates the shape of a body's bronchial tube, and transmits the air sucked from the intake port 111 to the alveolus formation unit 113 through the first and second branch pipes. Bronchial formation 112 of the piping structure;
It is mounted in a structure that communicates with one end of the bronchial formation unit 112, is a structure that creates the shape of alveoli in the body, and is a piping structure through which air delivered from the bronchial formation unit is transmitted, and the alveolar forming unit has a through hole at one end. (113);
Independently separated spaces are formed in each of the first and second branch organs of the bronchial formation portion 112, and are formed in a structure that surrounds the alveolar formation portion 113 to form a closed space, and are of a predetermined size. A closed shell housing (114) made of a rigid material; and
A plurality of people are mounted on the outer peripheral surface of the closed shell housing 114 at regular intervals, and the inside of the closed shell housing 114 and the intake port 130 are in communication with each other, and the closed shell housing 114 is operated by operating the intake port 130. An exhaust port 115 configured to exhaust the air inside the housing 114 to the intake port 130 through the exhaust tube 116;
A chemical exposure assessment system comprising:
According to paragraph 1,
The lung model unit 110,
The first step of creating a 3D model of the bronchial tubes using the Lung4cer model generator, an algorithm-based program for creating various types of bronchial and alveolar models;
The second step is to check the extracted 3D modeling data, make the first correction, check the quarterly holes, and set the thickness required for assembly;
A third step of converting data into 3D printer data and performing 3D printing; and
The fourth step of assembling the 3D printed lung model;
A chemical exposure assessment system, characterized in that it is manufactured by a manufacturing method comprising.
delete According to paragraph 1,
The lung model unit 110,
It is mounted on the inner surface of the nasal cavity of the intake port 111 and changes the degree of adhesiveness of the surface by exposing an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electric signal provided from the monitoring unit 140. A first mucosal portion having a flexible thin plate structure;
It is mounted on the inner surface of the bronchial formation portion 112 and changes the degree of adhesiveness of the surface by exposing an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electrical signal provided from the monitoring unit 140. A second mucosal portion having a flexible thin plate structure;
It is mounted on the inner surface of the alveolar forming part 113 and changes the degree of adhesion of the surface by exposing an adhesive material to the surface exposed to the inner space of the nasal cavity of the intake port 111 by an electric signal provided from the monitoring unit 140. A third mucosal portion with a flexible thin plate structure; and
Opening control units that are mounted on the exhaust ports 115 to operate independently and have a structure that adjusts the degree of opening according to a signal provided from the monitoring unit 140;
A chemical exposure assessment system comprising:
According to clause 4,
The intake eastern part 130,
It has a structure that communicates with one end of the pipe that is exhausted to the outside through the exhaust port 115, is mounted on one side of the monitoring unit 140, and has a structure that purifies the air delivered through the exhaust port 115 and discharges it to the outside. stoker (150);
Including,
The exhaust purification unit 150,
It is mounted on one side of the monitoring unit 140, and has a closed box structure in which a lower filter unit 152 is mounted at the bottom to suck in air delivered from the exhaust port 115, and an upper filter unit 154 is mounted at the top. Mounting frame (151);
A lower filter unit 152 that is mounted at the bottom of the mounting frame 151, has a detachable structure, and has a structure to filter particulate matter floating in the air delivered from the exhaust port 115;
A central filter unit (153) mounted on the top of the lower filter unit (152) and having a structure that forms a rotating vortex in the air delivered from the lower filter unit (152) and at the same time sprays a disinfectant mist to disinfect the air. and
An upper filter unit 154 mounted on the top of the central filter unit 153 and sterilizing the air by irradiating UV-C to the air delivered through the central filter unit 153;
A chemical exposure assessment system comprising:
According to clause 5,
The central filter unit 153,
It is mounted between the lower filter unit 152 and the upper filter unit 154, has a hollow cylinder structure extending in the direction of the lower filter unit 152 and the upper filter unit 154, and passes through the lower filter unit 152. A rotating cylinder (154a) that rotates to flow air into the upper filter unit (154) and form a rotating vortex at the same time;
A rotary support cylinder (154b), which has a hollow cylindrical structure surrounding the rotary cylinder (154a) and is rotatably mounted inside the rotary cylinder (154a);
A plurality of rotating protrusions ( 154c);
A plurality of them are formed at regular intervals on the outer peripheral surface of the rotary cylinder (154a), and are formed adjacent to the disinfectant mist receiving surface of the rotary protrusion (154c), and the disinfectant solution is injected between the rotary cylinder (154a) and the rotary support container (154b). An inner injection through-hole (154d) that allows the mist to flow into the internal hollow space; and
An injection nozzle (154e) mounted on the upper part of the exhaust purification unit (150) and injecting the disinfectant mist provided from the outside with a predetermined pressure between the rotating support cylinders (154b) of the rotating cylinder (154a);
A chemical exposure assessment system comprising:
According to clause 6,
The exhaust purification unit 150,
A filter discharge opening/closing unit (115a) that is mounted on the upper surface of the other side of the mounting frame (151), has a structure that opens or closes the internal storage space to the outside, and has a structure that opens to the outside so that the exhaust purification unit (150) can be taken out;
It is mounted on the inner side of the mounting frame 151, has a structure that supports both sides of the lower filter part 152, and supports the lower filter part 152 so that the sliding position can be changed through the filter discharge opening and closing part 115a. The lower rail (115b) of;
It is mounted on the inner side of the mounting frame 151 and supports both sides of the central filter unit 153, and supports the central filter unit 153 so that its sliding position can be changed through the filter discharge opening and closing unit 115a. central rail (115c); and
It is mounted on the inner side of the mounting frame 151, has a structure that supports both sides of the upper filter part 154, and supports the upper filter part 154 so that the sliding position can be changed through the filter discharge opening and closing part 115a. upper rail (115d) of;
A chemical exposure assessment system comprising: