KR102611674B1 - Method For Manufacturing Implants Having Micro-Texture Structure - Google Patents

Abstract

A method of manufacturing an implant including a micro-textured structure is disclosed. A method of manufacturing an implant according to an embodiment of the present invention includes a body forming step of manufacturing an implant body that forms an internal storage space having the volume and shape of the implant to be manufactured; An inner surface forming step of forming a plurality of indented grooves having a structure indented to a predetermined depth at regular intervals from the outer surface of the prosthesis main body produced in the main body forming step; An outer surface forming step of coating the outer surface of the implant main body manufactured from the inner surface forming step with a bioactive material and forming a micro-textured seating structure at the same position as the indented groove; A surface forming step of forming a micro-texture structure on the surface of the micro-texture seating structure formed from the outer surface forming step; and an internal filling step of sealing the implant body after injecting a filler having a preset viscosity into the body of the implant.
According to the present invention, it is possible to provide a method for manufacturing an implant that can be used as a human nose, male genitalia, and other implants, and has a micro-textured structure formed on the outer surface.

Description

Method for manufacturing implants having micro-texture structure {Method For Manufacturing Implants Having Micro-Texture Structure}

The present invention relates to a method of manufacturing an implant containing a micro-textured structure, and more specifically, to a method of manufacturing an implant that can be used as a human nose, male genitalia, and other implants.

BACKGROUND Implantable prosthetics, especially soft prosthetic implants, are used to replace or augment body tissue. The most common example of this is breast augmentation or reconstruction, but these implants are also used to modify the appearance of soft tissue in the buttocks, chin, calves, abdomen or arms, for example.

Many implants have textured surfaces, which reduces capsular contraction and helps keep the implant in place during postoperative healing. However, there is a possible link between the use of implants whose body has a textured surface and anaplastic large cell lymphoma (ALCL).

Considering this, it may be advantageous to provide implants of alternative designs.

Silimed and Polytech Health and Aesthetics sell silicone breast implants under the trade names BioDesign™ and Microthane™, respectively. These implants are spherical. It is fully encapsulated in polyurethane foam to provide products with reduced buildup.

According to the prior art, forming multiple texture structures on the surface of an implant requires multiple processes and a long manufacturing time, which has the problem of high manufacturing costs.

Therefore, there is a need for a technology that can solve the problems caused by the prior art mentioned above.

Korean Patent Publication No. 10-2019-0142772 (Publication date: December 27, 2019)

The purpose of the present invention is to provide a method for manufacturing an implant that can be used as a human nose, male genitalia, and other implants, and has a micro-textured structure formed on the outer surface.

A method of manufacturing an implant according to an aspect of the present invention to achieve this objective includes a body forming step of manufacturing an implant body that forms an internal storage space having the volume and shape of the implant to be manufactured; An inner surface forming step of forming a plurality of indented grooves having a structure indented to a predetermined depth at regular intervals from the outer surface of the prosthesis main body produced in the main body forming step; A physiologically active material is coated on the outer surface of the main body of the implant produced from the inner surface forming step, a mesh structure with a surface roughness of 50 to 500 ㎛ is formed over the entire surface, and a micro-textured seating structure is formed at the same position as the indented groove. Forming an outer surface; A surface forming step of forming a micro-texture structure on the surface of the micro-texture seating structure formed from the outer surface forming step; and an internal filling step of sealing the implant main body after injecting a filler having a preset viscosity into the implant main body with characteristics more flexible than the rigidity of the implant main body.

In one embodiment of the present invention, the main body forming step includes a plastic surgery area image acquisition step of acquiring a medical image of the patient's plastic surgery area; A 3D image generation step of automatically creating a three-dimensional volume rendering image including the skin, bone, and cartilage of the plastic surgery area from the medical image of the patient's plastic surgery area based on plastic surgery site cartilage data learned through artificial intelligence; A cartilage simulation generation step of simulating the cartilage of the plastic surgery area in the 3D volume rendering image; A seating test step in which the implant body selected from the virtual implant model database is seated on the cartilage and bone of the simulated molded area; A seating position setting step of setting a position of a micro texture to be formed on the outer peripheral surface of the seated implant body; A design completion step of designing a customized implant body by simulating the seated implant body; A mold manufacturing step of transmitting the 3D model obtained through the design completion step to a 3D printer and manufacturing a mold of a predetermined thickness having an injection port and a bubble port using the 3D printer; and a main body manufacturing step of filling silicone through the injection port of the mold, curing it for a predetermined period of time, and then destroying the mold to manufacture a hollow prosthesis body portion having a predetermined thickness.

In one embodiment of the present invention, the medical image of the plastic surgery area may be a low-dose CT or low-dose CBCT (Cone Beam Computed Tomography) image.

In addition, the 3D image generation step predicts the cartilage of the plastic surgery site from the medical image of the patient's plastic surgery site based on plastic surgery site cartilage data learned through machine learning or deep learning using high-dose medical images showing the cartilage of the plastic surgery site. It may be a configuration that includes a process.

In addition, the cartilage simulation generating step includes a skin thickness selection step of selecting a skin thickness from a plurality of options; A cartilage and bone shaping step in which part of the cartilage and bone in the plastic surgery area is shaved off depending on whether the rasp of the hump area progresses; A cartilage movement setting step of setting the movement of the cartilage of the plastic surgery area depending on whether the plastic surgery area tip surgery is performed; and an outline line correction step of naturally correcting the outline of the cartilage of the plastic surgery area.

In one embodiment of the present invention, the inner surface forming step includes a main body part fixing step of fixing the prosthesis main body manufactured from the main body forming step in a form that surrounds the lower surface and both sides; A body expansion step of injecting opaque spherical particles having a predetermined rigidity into the body of the implant, transforming the body into an expanded state of 150 to 200% of the volume of the implant to be manufactured, and then sealing the body of the implant; An indentation groove forming step of forming a plurality of indentation grooves with a depth of 50 to 70% of the thickness of the prosthesis main body on the outer peripheral surface of the prosthesis main body deformed through the main body expansion step at regular intervals at positions set through the seating position setting step; A silicone material having a stiffness of 150 to 200% of that of the silicone material constituting the implant main body is injected into the indentation groove formed through the indentation groove forming step, and a disk-shaped structure having a radius of a predetermined length radiates from the top of the indentation groove. A texture position forming step of forming a seating plate; and a main body restoration step of restoring the volume of the implant main body to its original state by discharging the opaque spherical particles injected into the main body of the implant to the outside.

In one embodiment of the present invention, the outer surface forming step may form a micro-textured seating structure on the seating plate formed through the texture position forming step.

In one embodiment of the present invention, the bioactive material may include antibiotics, antibacterial agents, biocides, anti-inflammatory agents, steroids, isolated fat cells, or combinations thereof.

In addition, the micro-textured structure includes silicone, polyurethane, polyester, polypropylene, polycarbonate, polyethylene, polybutylene, polymethyl methacrylate, polyvinyl chloride, polytetrafluoroethylene, polyethylene glycol, and polyethylene oxide. Or, it may be composed of a polymer selected from combinations thereof.

As described above, according to the prosthesis manufacturing method of the present invention, by providing a main body forming step, an inner surface forming step, an outer surface forming step, a surface forming step, and an internal filling step that perform a specific process, the human nose, It can be used as male genitalia and other implants, and can provide a method for manufacturing implants with a micro-textured structure formed on the outer surface.

In addition, according to the prosthesis manufacturing method of the present invention, a specific process is performed including an image acquisition step of the molded area, a 3D image generation step, a cartilage simulation creation step, a seating test step, a seating position setting step, a design completion step, a mold manufacturing step, and a main body. By providing a main body forming step that includes a part manufacturing step, it is possible to manufacture the main body of the implant with an accurate molded shape and volume by customizing it to the patient's plastic surgery area, thereby ensuring stable surgical results that match the intended results. We can provide implants that can be used.

In addition, according to the implant manufacturing method of the present invention, an implant having a structure having the intended texture and rigidity is manufactured by providing an external surface forming step and a surface forming step to form a micro-textured seating structure and a micro-textured structure of a specific structure. As a result, it is possible to provide an implant that can guarantee stable surgical results that match the intended results.

Figure 1 is a photograph showing an implant with a microtexture formed on the outer surface according to the prior art.
Figure 2 is a flowchart showing a method of manufacturing an implant according to an embodiment of the present invention.
FIG. 3 is a flowchart specifically showing the main body portion forming step of the prosthesis manufacturing method shown in FIG. 2.
FIG. 4 is a flowchart specifically showing the cartilage simulation generation step of the prosthesis manufacturing method shown in FIG. 2.
FIG. 5 is a flowchart specifically showing the inner surface forming step of the prosthesis manufacturing method shown in FIG. 2.
Figure 6 is a process schematic diagram showing a method of manufacturing an implant according to an embodiment of the present invention.
Figure 7 is a process schematic diagram showing a method of manufacturing an implant according to an embodiment of the present invention.
Figure 8 is a photograph showing a medical image of a patient's plastic surgery site in the plastic surgery site image acquisition step of the main body forming step according to an embodiment of the present invention.
Figure 9 is a photograph showing a 3D volume rendering image of the 3D image generation step of the main body forming step according to an embodiment of the present invention.
Figure 10 is a photograph showing the seating test step of the main body forming step according to an embodiment of the present invention.
Figure 11 is a photograph showing a 3D model of the seating position setting step and design completion step of the main body forming step according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. Prior to this, terms and words used in this specification and claims should not be construed as limited to their usual or dictionary meanings, but should be construed with meanings and concepts consistent with the technical idea of the present invention.

Throughout this specification, when a member is said to be located “on” another member, this includes not only cases where a member is in contact with another member, but also cases where another member exists between the two members. Throughout this specification, when a part "includes" a certain component, this means that it may further include other components rather than excluding other components, unless specifically stated to the contrary.

Figure 2 shows a flow chart showing another method of manufacturing an implant according to an embodiment of the present invention.

Referring to FIG. 2, the implant manufacturing method (S100) according to this embodiment includes a main body forming step (S110), an inner surface forming step (S120), an outer surface forming step (S130), and a surface forming step that perform a specific process. By providing (S140) and the internal filling step (S150), it is possible to provide a method of manufacturing an implant that can be used as a human nose, male genitalia, and other implants, and has a micro-texture structure 130 formed on the external surface. You can.

Hereinafter, with reference to the drawings, each component constituting the implant manufacturing method (S100) according to this embodiment will be described in detail.

FIG. 3 shows a flow chart specifically showing the main body forming step of the prosthesis manufacturing method shown in FIG. 2, and FIG. 4 shows a flow chart specifically showing the cartilage simulation generating step of the prosthesis manufacturing method shown in FIG. 2. FIG. 5 shows a flowchart specifically showing the inner surface forming step of the prosthesis manufacturing method shown in FIG. 2.

Figure 6 shows a process schematic diagram showing a method for manufacturing an implant according to an embodiment of the present invention, and Figure 7 shows a process schematic diagram showing a method for manufacturing an implant according to an embodiment of the present invention. In addition, Figure 8 shows a photograph showing a medical image of the patient's plastic surgery area in the plastic surgery area image acquisition step of the main body forming step according to an embodiment of the present invention, and Figure 9 shows a photo showing a medical image of the patient's plastic surgery site according to an embodiment of the present invention. A photo showing a 3D volume rendering image of the 3D image generation step of the part forming step is shown, and Figure 10 shows a photo showing a seating test step of the main body forming step according to an embodiment of the present invention. In addition, Figure 11 shows a photograph showing a 3D model in the seating position setting step and design completion step of the main body forming step according to an embodiment of the present invention.

Referring to FIGS. 2 to 11, the main body forming step (S110) according to this embodiment is a process of manufacturing the implant main body 110 that forms an internal storage space having the volume and shape of the implant to be manufactured. do.

In the inner surface forming step (S120) according to this embodiment, the indented grooves 120, which are indented to a predetermined depth, are spaced at a predetermined distance from the outer surface of the prosthesis main body 110 manufactured in the main body forming step (S110). Perform a majority forming process.

In the outer surface forming step (S130) according to this embodiment, the outer surface of the prosthesis body 110 manufactured from the inner surface forming step (S120) is coated with the bioactive material 111, and the same as the indented groove 120 is formed. The process of forming the micro-texture seating structure 131 at the location is performed. Here, the above-mentioned bioactive material 111 may be composed of antibiotics, antibacterial agents, biocides, anti-inflammatory agents, steroids, isolated fat cells, or combinations thereof.

The surface forming step (S140) according to this embodiment performs a process of forming a micro-textured structure 130 on the surface of the micro-textured seating structure 131 formed in the outer surface forming step (S130).

The internal filling step (S150) according to this embodiment performs a process of injecting a filler having a preset viscosity into the implant body 110 and then sealing the implant body 110.

Specifically, as shown in FIGS. 2, 3, 4, 6, 8, and 9, the main body forming step (S110) according to this embodiment includes an image acquisition step of the forming area performing a specific process ( S111), 3D image generation step (S112), cartilage simulation creation step (S113), seating test step (S114), seating position setting step (S115), design completion step (S116), mold manufacturing step (S117), and main body part It may be a configuration that includes a manufacturing step (S118).

The plastic surgery area image acquisition step (S111) of the main body forming step (S110) performs a process of acquiring a medical image of the patient's plastic surgery area. At this time, the medical image of the above-mentioned plastic surgery area is preferably a low-dose CT or low-dose CBCT (Cone Beam Computed Tomography) image.

The 3D image generation step (S112) of the main body forming step (S110) is based on plastic surgery site cartilage data learned through artificial intelligence, and a 3D image including the skin, bone, and cartilage of the plastic surgery site from the medical image of the patient's plastic surgery site. The process of automatically implementing volume rendering images is performed. At this time, in the 3D image generation step (S112), plastic surgery is performed from the medical image of the patient's plastic surgery site based on plastic surgery site cartilage data learned through machine learning or deep learning using high-dose medical images showing the cartilage of the plastic surgery site. It may include a process of predicting regional cartilage.

The cartilage simulation generation step (S113) of the main body forming step (S110) performs a process of simulating the cartilage of the forming area in the 3D volume rendering image. At this time, the cartilage simulation creation step (S113) is a skin thickness selection step (S113a) in which the thickness of the skin is selected from a plurality of options, and the cartilage of the plastic surgery site and the bone of the plastic surgery site are selected depending on whether the rasp of the hump portion progresses. A cartilage and bone shaping step (S113b) that shaves off part of the plastic surgery site, a cartilage movement setting step (S113c) that sets the movement of the cartilage in the plastic surgery site depending on whether tip surgery is performed, and an outline line that naturally corrects the outer line of the cartilage in the plastic surgery site. It may be a configuration that includes a correction step (S113d).

The seating test step (S114) of the body forming step (S110) performs a process of seating the implant body portion 110 selected from the virtual implant model database onto the cartilage and bone of the simulated molded area. The seating position setting step (S115) performs a process of setting the position of the microtexture to be formed on the outer peripheral surface of the seated prosthesis main body 110. The design completion step (S116) performs a process of designing a customized implant body 110 by simulating the seated implant body 110. In the mold manufacturing step (S117), the 3D model obtained through the design completion step (S116) is transferred to a 3D printer and a mold of a predetermined thickness having an injection port and a bubble port is manufactured using the 3D printer. In addition, the main body manufacturing step (S118) involves filling silicone through the injection port of the mold, curing it for a predetermined period of time, and then destroying the mold to manufacture the hollow implant main body 110 with a predetermined thickness. .

Meanwhile, as shown in FIGS. 2, 5, 6, 7, 10, and 11, the inner surface forming step (S120) in this embodiment is a main body fixing step (S121) that performs a specific process. , the main body expansion step (S122), the indented groove forming step (S123), the texture position forming step (S124), and the main body restoration step (S125).

Specifically, the main body part fixing step (S121) of the inner surface forming step (S120) performs a process of fixing the prosthetic body part 110 manufactured from the main body forming step (S110) in a form that surrounds the lower surface and both sides. . In the main body expansion step (S122), opaque spherical particles 150 having a predetermined size and rigidity are injected into the implant main body 110 to expand the body to a volume of 150 to 200% of the volume of the implant to be manufactured. After deformation, a process of sealing the implant body 110 is performed. In the indentation groove forming step (S123), an indentation groove 120 with a depth of 50 to 70% of the thickness of the prosthesis main body 110 is seated on the outer peripheral surface of the prosthesis main body 110 transformed through the main body expansion step S122. In the position setting step (S115), a process of forming a plurality of units is performed by spacing them out at regular intervals at a set location. In the texture position forming step (S124), a silicone material having a stiffness of 150 to 200% of that of the silicone material constituting the implant main body 110 is injected and indented into the indented groove 120 formed through the indented groove forming step (S123). A process is performed to form a seating plate 121 having a disk-shaped structure having a radius of a predetermined length in a radial form from the top of the groove 120. In addition, the main body restoration step (S125) is a process of restoring the volume of the implant main body 110 to its original state by discharging the opaque spherical particles 150 injected into the implant main body 110 to the outside. Perform.

Meanwhile, the outer surface forming step (S130) according to this embodiment may be performed by forming a micro-texture seating structure 131 on the seating plate 121 formed through the texture position forming step (S124).

At this time, the micro-texture structure 130 is made of silicone, polyurethane, polyester, polypropylene, polycarbonate, polyethylene, polybutylene, polymethyl methacrylate, polyvinyl chloride, polytetrafluoroethylene, and polyethylene glycol, It is preferable that the composition includes a polymer selected from polyethylene oxide or combinations thereof.

As described above, according to the prosthesis manufacturing method of the present invention, a main body forming step (S110), an inner surface forming step (S120), an outer surface forming step (S130), and a surface forming step (S140) are performed to perform a specific process. And by providing an internal filling step (S150), it is possible to provide a method of manufacturing an implant that can be used as a human nose, male genitalia, and other implants, and has a micro-texture structure 130 formed on the external surface.

In addition, according to the prosthesis manufacturing method of the present invention, a specific process is performed including an image acquisition step of the molded area (S111), a 3D image generation step (S112), a cartilage simulation generation step, a seating test step (S114), and a seating position setting step ( By providing a main body forming step (S110) including a design completion step (S116), a mold manufacturing step (S117), and a main body manufacturing step (S118), it can be tailored to the patient's molded area to create an accurate molded form. It is possible to manufacture the implant main body 110 having a volume, and as a result, it is possible to provide an implant that can ensure stable surgical results consistent with the intended results.

In addition, according to the implant manufacturing method of the present invention, by providing an external surface forming step (S130) and a surface forming step (S140) to form the micro-textured seating structure 131 and the micro-textured structure 130 of a specific structure, It is possible to manufacture an implant with a structure that has the desired texture and rigidity, and as a result, it is possible to provide an implant that can guarantee stable surgical results that match the intended results.

In the above detailed description of the present invention, only special embodiments thereof have been described. However, it should be understood that the present invention is not limited to the particular form mentioned in the detailed description, but rather is understood to include all modifications, equivalents and substitutes within the spirit and scope of the present invention as defined by the appended claims. It has to be.

That is, the present invention is not limited to the specific embodiments and descriptions described above, and various modifications may be made by anyone skilled in the art without departing from the gist of the present invention as claimed in the claims. is possible, and such modifications fall within the scope of protection of the present invention.

100: Implants
110: Prosthesis main body
111: Bioactive materials
120: Indented groove
121: Seating plate
122: Seating pillar
130: Micro-textured structure
131: Micro texture seating structure
140: Filling
150: Opaque spherical particle
S100: Implant manufacturing method
S110: Main body forming step
S111: Image acquisition step of plastic surgery area
S112: 3D image creation step
S113: Cartilage simulation creation step
S113a: Skin thickness selection step
S113b: Cartilage and bone shaping stage
S113c: Cartilage movement setting step
S113d: Outline line correction step
S114: Seating test step
S115: Seating position setting step
S116: Design completion stage
S117: Mold manufacturing step
S118: Main body manufacturing stage
S120: Internal surface forming step
S121: Main body fixing step
S122: Main body expansion step
S123: Indentation groove formation step
S124: Texture position formation step
S125: Main body restoration step
S130: Outer surface forming step
S140: Surface formation step
S150: Internal filling step

Claims (5)

A body forming step (S110) of manufacturing an implant body 110 that forms an internal storage space having the volume and shape of the implant to be manufactured;
An inner surface forming step (S120) of forming a plurality of indented grooves 120 having a structure indented to a predetermined depth from the outer surface of the prosthesis main body 110 produced in the main body forming step (S110) at regular intervals;
A physiologically active material is coated on the outer surface of the prosthesis main body 110 manufactured from the inner surface forming step (S120), a mesh structure having a surface roughness of 50 to 500 ㎛ is formed over the entire surface, and an indented groove 120 is formed. ), an external surface forming step (S130) of forming a micro-textured seating structure 131 at the same position as (S130);
A surface forming step (S140) of forming a micro-textured structure 130 on the surface of the micro-textured seating structure 131 formed from the outer surface forming step (S130); and
An internal filling step (S150) of sealing the implant body 110 after injecting a filler having a preset viscosity into the implant body 110 and having characteristics more flexible than the rigidity of the implant body 110;
A method of manufacturing an implant comprising:
According to paragraph 1,
In the main body forming step (S110),
A plastic surgery area image acquisition step (S111) of acquiring a medical image of the patient's plastic surgery area;
Based on plastic surgery site cartilage data learned through artificial intelligence, a 3D image generation step (S112) of automatically creating a 3D volume rendering image including the skin, bone, and cartilage of the plastic surgery site from a medical image of the patient's plastic surgery site;
A cartilage simulation generation step (S113) that simulates the cartilage of the plastic surgery area in the 3D volume rendering image;
A seating test step (S114) in which the implant body portion 110 selected from the virtual implant model database is seated on the cartilage and bone of the simulated molded area;
A seating position setting step (S115) of setting the position of the microtexture to be formed on the outer peripheral surface of the seated implant body portion 110;
A design completion step (S116) of designing a customized implant body 110 by simulating the seated implant body 110;
A mold manufacturing step (S117) of sending the 3D model obtained through the design completion step (S116) to a 3D printer and manufacturing a mold of a predetermined thickness having an injection port and a bubble port using the 3D printer; and
A main body manufacturing step (S118) of filling silicone through the injection port of the mold, curing it for a predetermined period of time, and then destroying the mold to manufacture a hollow implant body 110 having a predetermined thickness;
A method of manufacturing an implant comprising:
According to paragraph 2,
The medical image of the plastic surgery area is,
It is a low-dose CT or low-dose CBCT (Cone Beam Computed Tomography) image,
In the 3D image generation step (S112),
A process of predicting plastic surgery site cartilage from a patient's plastic surgery site medical image based on plastic surgery site cartilage data learned through machine learning or deep learning using high-dose medical images showing plastic surgery site cartilage;
Including,
In the cartilage simulation creation step (S113),
A skin thickness selection step (S113a) of selecting a skin thickness from a plurality of options;
A cartilage and bone shaping step (S113b) in which part of the cartilage and bone in the plastic surgery area is shaved off depending on whether the rasp of the hump area progresses;
A cartilage movement setting step (S113c) that sets the movement of the cartilage in the plastic surgery area depending on whether the surgery is performed on the tip of the plastic surgery area; and
An outline line correction step (S113d) that naturally corrects the outline of the cartilage in the plastic surgery area;
A method of manufacturing an implant comprising:
According to paragraph 2,
The inner surface forming step (S120) is,
A main body part fixing step (S121) of fixing the prosthetic body part 110 manufactured from the main body forming step (S110) in a shape that surrounds the lower surface and both sides;
Inject opaque spherical particles 150 having a predetermined size of rigidity into the implant main body 110, transform them into an expanded state of 150 to 200% of the volume of the implant to be manufactured, and then form the implant main body ( A main body expansion step (S122) of sealing 110);
An indented groove 120 with a depth of 50 to 70% of the thickness of the implant body 110 is formed on the outer peripheral surface of the implant body 110, which has been modified through the main body expansion step (S122), through the seating position setting step (S115). A step of forming indented grooves (S123) in which a plurality of indented grooves are formed at predetermined intervals at a set position;
A silicone material having a stiffness of 150 to 200% of that of the silicone material constituting the implant body 110 is injected into the indentation groove 120 formed through the indentation groove forming step (S123) and injected from the top of the indentation groove 120. A texture position forming step (S124) of forming a seating plate 121 of a disk-shaped structure having a radius of a predetermined length in a radial form; and
A body restoration step (S125) in which the opaque spherical particles 150 injected into the implant body 110 are discharged to the outside to restore the volume of the implant body 110 to its original state;
A method of manufacturing an implant comprising:
According to paragraph 4,
In the outer surface forming step (S130),
Forming a micro-texture seating structure 131 on the seating plate 121 formed through the texture position forming step (S124),
The physiologically active material is,
Contains antibiotics, antibacterial agents, biocides, anti-inflammatory agents, steroids, isolated fat cells, or combinations thereof,
The micro-texture structure 130 is,
A polymer selected from silicone, polyurethane, polyester, polypropylene, polycarbonate, polyethylene, polybutylene, polymethyl methacrylate, polyvinyl chloride, polytetrafluoroethylene, polyethylene glycol, polyethylene oxide, or combinations thereof. A method of manufacturing an implant comprising: