KR102600590B1 - Composition for topical skin application for feeling of swelling and warmth to the male genital organ, and improving blood circulation - Google Patents

Abstract

The present invention relates to a composition for external application for skin containing caffeine, ginger extract, and vanillyl butyl ether as active ingredients, wherein the caffeine is contained at 0.10% by weight, the ginger extract is at 0.10% by weight, and the vanillin butyl ether is at 0.02% by weight. The composition further includes purified water, glycerin, butylene glycol, and 1,2-hexanediol, and the purified water, glycerin, butylene glycol, and 1,2-hexanediol are added to the total weight. Provided is a composition for external application for skin that provides a feeling of swelling and warmth to the male genitalia and improves blood circulation, characterized in that it contains 50% to 97% by weight.

Description

Composition for topical skin application for feeling of swelling and warmth to the male genital organ, and improving blood circulation}

The present invention relates to a composition for external application to the skin that provides a feeling of swelling and warmth to the male genitalia and improves blood circulation.

As adult diseases and stress increase, the number of people suffering from erectile dysfunction is gradually increasing. Erectile dysfunction refers to the inability to achieve or sustain sufficient rigidity for normal sexual intercourse even after receiving sexual stimulation. According to a 2013 publication in the Journal of Sexual Medicine, one in four patients with erectile dysfunction was under the age of 40, and the average age was only 32, so erectile dysfunction among young people is on the rise.

Erectile dysfunction occurs due to psychogenic, organic (physiological abnormalities) or a combination of these factors. Important causes of organic erectile dysfunction include vascular abnormalities, neurologic defects, and side effects of drug treatment.

The primary vascular causes of erectile dysfunction are arterial insufficiency, which prevents the penis from filling with blood, and venous dystrophy, which prevents blood from being maintained within the penis while erect. Arterial insufficiency is primarily caused by arteriosclerosis and has been found to be worsened by smoking.

Research on treatment methods for erectile dysfunction includes 1) correction of reversible causes, 2) oral medications, 3) vacuum compressors , 4) intraurethral injection, 5) intracavernosal injection, 6) surgical treatment, and 7) erectile dysfunction. and a thorough discussion and evaluation of related psychological issues.

1) Correction for reversible causes

If diabetes, high blood pressure, hyperlipidemia, etc. are present, these should be treated first. It is also necessary to improve lifestyle habits such as smoking, obesity, and lack of exercise. In fact, research results have reported that erectile dysfunction can be improved with just regular exercise. Although overall weight is important in weight control, correction of abdominal obesity is known to be especially important.

2) Oral medication

Oral medication is the primary method used to treat erectile dysfunction. Medicines include Viagra, Cialis, and Levitra, and there are also domestically developed drugs such as Zydena and M-Vix. Although they show slight differences in drug absorption, action time, etc., the mechanism of action of the drugs is fundamentally the same. These drugs can be most effective only if they are preceded by appropriate sexual stimulation.

Viagra is the first oral erectile dysfunction treatment and is taken one hour before sexual activity, while Cialis has the characteristic of having a long duration of action. Common side effects of these medications include headache, facial flushing, and blurred vision. Patients for whom oral medications are contraindicated include those with hypersensitivity to the drug and those taking nitrate preparations (medication to treat angina pectoris). Uprima, introduced as another oral medication, is a drug that acts on the brain by activating the medial nucleus and paraventricular nucleus of the hypothalamus. Sales were recently discontinued because the effects were not satisfactory and the side effects were severe.

3) Vacuum compressor

A vacuum compressor is a device that uses vacuum to forcibly increase the amount of blood inflow into the corpus cavernosum and then blocks the outflow of blood with a compression band to induce and maintain an erection. It is a very effective treatment method and can be considered as a primary treatment along with oral medications, so it is widely used in the West. However, Korean patients do not prefer it due to decreased sensation and cold feeling, so its use rate is low in Korea.

Due to safety issues, only certified medical devices should be used, but the reality is that these are difficult to obtain in Korea these days. Caution is required as there may be cases of damage to the penis by using devices that are not certified as medical devices.

4) Intraurethral injection method

A drug called MUSE (Medicated Urethral System for Erection) has the effect of causing an erection by injecting a vasodilator into the urethra. Although it is an effective treatment, it has been reported to cause very severe penile pain and urethral pain, hardening fibrosis of the corpus cavernosum, dizziness, facial flushing, and orthostatic hypotension, and is currently discontinued from the market in Korea.

5) Intracavernosal injection therapy

If oral medication is ineffective, it is a secondary treatment that can be tried next. Multiple vasodilators are injected singly or in combination, and education on safe injection techniques and appropriate dosage determination must first be conducted. Patient satisfaction is very high, but side effects can include pain, fibrosis, and priapism, and the dropout rate is high.

6) Surgical treatment

In healthy young patients whose penile arteries are partially blocked mainly due to injury, penile artery reconstruction can be performed selectively. In cases where a satisfactory erection effect cannot be achieved despite various treatments, a surgical treatment that can generally be considered is penile prosthesis insertion. There are two types of penile prosthesis: non-inflatable and inflatable, and they have the advantage of very high satisfaction level after the procedure. However, the price of the device is high, complications such as infection, erosion, pain, penile bending, and mechanical dysfunction may occur, and once the procedure is performed, the ability to have an erection is completely lost, so you must be very careful in your choice.

7) There is a thorough discussion and evaluation of erectile dysfunction and related psychological problems. Additionally, it is necessary to evaluate predispositions (psychological trauma, stress, relationship problems, etc.) and triggers (ongoing marital problems, cultural factors, etc.). [Naver Knowledge Encyclopedia] Erectile dysfunction [erectile dysfunction] (Seoul National University Hospital medical information, Seoul National University Hospital)

Meanwhile, U.S. Patent No. 4,801,587 describes a method of treating erectile dysfunction using ointment. This ointment consists of papaverine, hydralazine, sodium nitroperoxide, phenoxybenzamine or phentolamine as vasodilators, and a carrier that helps the skin absorb the main drug. Most recently, sildenafil citrate (U.S. Patent No. 6,200,591) began to be marketed as an oral dosage form.

However, the above drugs have problems in that the effects are minimal or even if effective, the side effects are severe and they must be administered under strict supervision by a doctor. In addition, oral preparations must be taken at least 30 minutes before sexual activity, and injectable preparations require the patient to inject directly into the genitals just before sexual intercourse, which not only interferes with sexual activity that requires an appropriate atmosphere but is also very difficult to administer. There is a problem. Therefore, there is an urgent need to develop new topical agents that are effective and have no side effects.

Meanwhile, the development of the penis is completed around the age of 21. A case in which the length of the penis is less than 4 cm even as an adult due to congenital reasons or problems during the development process is generally referred to as dwarfism. Although the person has a normal-sized penis from a medical perspective, the size of the penis is determined regardless of the actual size of the penis. Having a complex due to underestimation and overestimation of the size of the penis of others is called dwarf penis neurosis. Penile dwarfism is also referred to as locker room complex. In men, the size of the penis is not limited to simply improving sexual satisfaction, but is also very beneficial in terms of increasing confidence in interpersonal relationships and resolving emotional dissatisfaction. occupies an important part.

Penis enlargement refers to various methods to increase the size of the penis of a human male, and the goal of the method is to increase the length, thickness and circumference of the penis, and the size of the glans. Penis enlargement is performed along with psychological treatment not only for the above-described penile dwarfism but also for penile dwarfism neurosis. It plays a role in solving psychological problems caused by penile dwarfism and the size of the penis, and actually makes social life smoother by restoring confidence. Cases exist.

Methods for enlarging the circumference and length of the penis include surgical and non-surgical methods. Surgical methods include autologous dermal transplantation, autologous fat transplantation, replacement dermal transplantation, filler surgery, implant insertion, and suspensory ligament amputation, while non-surgical methods include using decompression pumps, jelqing exercises, and traction devices.

Surgical methods have disadvantages such as pain, scarring, infection, inflammation, and skin necrosis due to complex and difficult surgical procedures. Alternative dermal transplantation is relatively simple to perform and has the effect of enlarging the circumference of the penis, but is prone to immune rejection, immune rejection, and skin necrosis. There are disadvantages such as leaving scars and traces of the procedure. In addition, autologous fat transplantation, which uses unnecessary fat in the body and transplants it under the skin of the penis, and filler surgery that injects ingredients such as hyaluronic acid are simple procedures, but autologous fat transplantation is generally satisfactory because 75% of the fat is decomposed in the body. It is difficult to obtain acceptable results, and there are problems such as deformation of the shape of the penis after surgery. In the case of filler surgery, there is a disadvantage in that there is a sign of drug injection and the ingredients are absorbed over time, requiring reoperation. In addition, implant insertion surgery involves implanting an implant made of silicone into the penis. The implanted silicone is not absorbed, so it can provide a permanent penis enlargement effect. However, it can cause physical stimulation such as sexual intercourse or deformation over time, an unnatural shape, and a foreign body sensation. It has disadvantages such as high incidence of inflammation. In addition, suspensory ligament amputation is a method of penis enlargement through cutting of the suspensory ligament. It has the effect of lengthening the length of the penis before erection, but has the disadvantage of not having a significant effect on the length after erection and that sexual dysfunction may occur.

A pressure-reducing pump, which is a non-surgical method that uses a method of expanding the penis and drawing blood into the penis by creating negative pressure, can lead to permanent damage to the penis and cause erectile dysfunction if used inappropriately, and can cause erectile dysfunction by pulling on the glans of the penis for a long time. Traction devices that use devices to stretch the penis can also cause permanent damage to the penis, and there are reports that they only showed significant results in men with short penises, so there are limits to their effectiveness. In addition, in the case of jelqing exercise, it is a safe method that is less likely to cause serious damage to the penis compared to the above-mentioned pressure pump or traction device, but its effectiveness is so low that there are opinions that simply jelqing exercise alone has no significant biological significance or has no effect at all on penis enlargement. I have a question.

Therefore, there is a need for a penis enlargement technology that can effectively achieve a penis enlargement effect without causing side effects such as damage to the penis or foreign body sensation, as mentioned above.

Meanwhile, premature ejaculation refers to a condition where a person continuously and repeatedly ejaculates just before or after insertion despite sexual stimulation, or when the delay time to ejaculation is extremely short. Treatments for premature ejaculation include psychotherapy, local anesthesia, and the use of devices. All of these methods have significant drawbacks. Psychotherapy is effective for some premature ejaculation patients, and when it is not acceptable for all premature ejaculation patients, special treatments are needed. Moreover, psychotherapy cannot alleviate premature ejaculation caused by non-psychological causes. Anesthetics reduce tissue response, reducing sexual pleasure. Additionally, local anesthesia is transmitted to the sexual partner, reducing both sensitivity and pleasure. When it comes to device therapy, it is awkward, uncomfortable, and embarrassing to use. The device effectively reveals what the premature ejaculation patient is trying to hide.

In addition, since penile enlargement and premature ejaculation need to be improved at the same time, an external agent that can be used conveniently and has a different mechanism of action is needed.

KR1020040010779A KR1020220095801A KR1020160120941A KR1020120049048A KR102196533B

In order to solve the above problems, the purpose of the present invention is to provide a composition for external application to the skin for temporarily enlarging the thickness of the male genitalia, improving blood circulation, and delaying ejaculation.

In order to achieve the above object, the present invention,

Provided is a skin external composition that temporarily enlarges the thickness of the male genitalia, improves blood circulation, and delays ejaculation, containing caffeine, ginger extract, and vanillyl butyl ether as active ingredients.

The composition is,

Glycerin, butylene glycol, 1,2-hexane diol, polyglyceryl-10 laurate, diethyl hexyl sodium sulfosuccinate, olive oil glycerol-8 ester, caffeine, ginger extract, vanillyl butyl ether. , glycine, serine, glutamic acid, aspartic acid, leucine, alanine, lysine, arginine, tyrosine, phenylalanine, threonine, proline, valine, isoleucine, histidine, cysteine, methionine, sodium hyaluronate, hydrol. Containing 5% to 20% by weight of raised hyaluronyl acid, hyaluronic acid, sodium hyaluronate crosspolymer, hydrolyzed sodium hyaluronate, and potassium hyaluronate relative to the total weight. It is characterized by

It is characterized in that the caffeine, ginger extract, and vanillin butyl ether are contained in an amount of 0.05% by weight to 2% by weight based on the total weight.

The caffeine, ginger extract, and vanillin butyl ether are characterized in that they have a weight ratio of 40:40:20 to 47:47:6.

The composition is characterized by causing a warm sensation on the skin to which it is applied.

The composition is characterized in that it is used to improve blood circulation in the skin to which it is applied.

The composition is characterized by causing a feeling of swelling in the skin to which it is applied.

The composition is characterized in that it causes both a feeling of warmth and swelling.

The composition is characterized in that it contains purified water, glycerin, butylene glycol, and 1,2-hexanediol in an amount of 50% to 97% by weight based on the total weight.

The purified water, glycerin, butylene glycol, and 1,2-hexanediol are characterized in that they are included in a weight ratio of 75:9:8:8 to 89:3:4:4.

It is characterized in that the polyglyceryl-10 laurate, diethylhexyl sodium sulfosuccinate, and olive oil glycereth-8 ester are included in an amount of 2% to 10% by weight based on the total weight.

The polyglyceryl-10 laurate, diethylhexyl sodium sulfosuccinate, and olive oil glycereth-8 ester are characterized in that they are included in a weight ratio of 50:0.5:49.5 to 70:7:23.

The composition is characterized in that it is formulated as one selected from gel, cream, or liquid.

According to an embodiment of the present invention constructed as described above, as a transdermal application for the male genitalia, it provides a feeling of swelling through immediate and temporary improvement of blood circulation through rapid absorption of the formulation and effective penetration into the epidermis, and temporary ejaculation induced by the accompanying warmth. There is a delay effect.

According to an embodiment of the present invention, it is possible to provide a composition for topical skin application that is effective in helping men with premature ejaculation.

Figure 1 is a graph showing the degree of improvement in skin micro-blood flow as a result of applying an external skin composition according to an embodiment of the present invention to a test subject.
Figure 2 is a graph showing the improvement rate of skin micro-blood flow as a result of applying the external skin composition according to an embodiment of the present invention to a test subject.
Figure 3 is a graph showing the thermal sensation felt as a result of applying the external skin composition according to an embodiment of the present invention to a test subject.
Figure 4 is a graph showing the swelling felt as a result of applying the external skin composition according to an embodiment of the present invention to a test subject.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the technical idea of the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosed content will be thorough and complete and so that the spirit of the invention can be sufficiently conveyed to those skilled in the art.

In this specification, when an element is referred to as being on another element, it means that it may be formed directly on the other element or that a third element may be interposed between them. Additionally, in the drawings, the shape and size are exaggerated for effective explanation of technical content.

In the following description of the present invention, if a detailed description of a related known function or configuration is judged to unnecessarily obscure the gist of the present invention, the detailed description will be omitted.

When caffeine, ginger extract, and vanillyl butyl ether according to an embodiment of the present invention are applied to the male genitals as active ingredients, the effect of temporarily delaying ejaculation is induced by providing a feeling of swelling through temporary improvement of blood circulation and the accompanying heat sensation. Brings .

Caffeine is a type of alkaloid contained in the fruits, leaves, and seeds of some plants such as coffee and tea. It has a xanthine structure with three methyl groups and is a white crystal with a bitter taste. Caffeine has pharmacological effects such as a central nervous system stimulant, tonic, and diuretic, and has the effect of decomposing fat, especially cellulite. Caffeine increases the amount of cAMP by inhibiting the activity of nucleotide phosphodistease. In addition, caffeine promotes blood circulation, quickly delivering moisture and nutrients to cells, and dilating blood vessels.

Ginger is a perennial herb of the monocotyledonous plant Ginger family, and its roots are used for edible and medicinal purposes. The rhizome grows sideways, is fleshy, lump-shaped, yellow, and has a spicy taste and fragrant smell. In oriental medicine, the dried rhizome is used as a medicine called health (乾薑). It is effective for indigestion, vomiting, and diarrhea, promotes blood circulation, and has anti-inflammatory and analgesic effects. Zingiber Officinale (Ginger) Root Extract, used as a cosmetic ingredient, is a raw material extracted from the root of ginger.

Vanillyl Butyl Ether is an oil-soluble heat sensitizer. After acting locally on the skin, such as promoting microcirculation, promoting subcutaneous fat metabolism, and promoting capillary circulation, it can quickly produce a light and long-lasting heating effect. The thermal sensation of vanillyl butyl ether is several times that of common pepper extract, has low irritancy, the thermal sensation is maintained for several hours, and a strong thermal sensation can be obtained at a very low dose. Additionally, vanillyl butyl ether is a safe ingredient with a stable vanilla flavor. The effect appears quickly within 5 minutes after being applied to the skin, and provides a thermal sensation that lasts for up to 2 hours. Vanillyl Butyl Ether is an ingredient that provides a warming sensation to the skin without being irritating to the skin compared to capsaicin or menthol ingredients. Vanillyl butyl ether is a substance that is more stable in an emulsion state than when it is oil-soluble and water-soluble. Vanillyl butyl ether is an FDA-approved and safe ingredient that has no environmental toxicity and does not accumulate, so it can be used as a skin conditioning agent.

The composition for external application for skin according to an embodiment of the present invention contains the sum of caffeine, ginger extract, and vanillin butyl ethyl in an amount of 0.05% by weight to 2% by weight based on the total weight to provide an appropriate sense of warmth and delay ejaculation, and the composition improves blood circulation. For this purpose, it is preferable that caffeine, ginger extract, and vanillin butyl ethyl be included in a weight ratio of 40:40:20 - 47:47:6.

The composition for external application for skin according to an embodiment of the present invention contains caffeine, ginger extract, and vanillin butyl ethyl in an amount of 0.05% to 2% by weight relative to the total weight to improve blood circulation, and the composition contains caffeine, ginger extract, and It is preferable that vanillin butylethyl is included in a weight ratio of 40:40:20 to 47:47:6.

The external skin composition according to an embodiment of the present invention includes purified water, glycerin, butylene glycol, 1,2-hexanediol, caffeine, hydrogenated polyisobutene, Zymo root extract, and sericin. , ginger extract, palmitoyl tripeptide-1, glycine, serine, glutamic acid, aspartic acid, leucine, alanine, lysine, arginine, tyrosine, phenylalanine, threonine, proline, valine, isoleucine, histidine, cysteine, Methionine, Sodium Hyaluronate, Hydroxypropyl Trimonium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronyl Acid, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer , Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Vanillin Butyl Ether, Polyglyceryl-10 Laurate, Diethylhexyl Sodium Sulfosuccinate, Dipropylene Glycol, Olive Oil Glycereth- It consists of 8 ester, carbomer, tromethamine (Tris), disodium EDTA, ethylhexylglycerin, blue No. 1, and yellow No. 4.

The skin external composition according to an embodiment of the present invention contains caffeine, ginger extract, vanillin butyl ethyl, glycine, serine, glutamic acid, aspartic acid, leucine, alanine, lysine, arginine, Tyrosine, phenylalanine, threonine, proline, valine, isoleucine, histidine, cysteine, methionine, sodium hyaluronate, hydrolyzed hyaluronyl acid, hyaluronic acid, sodium hyaluronate crosspolymer, hydrochloride It is characterized in that it contains 0.1% to 2.0% by weight of rolled sodium hyaluronate and potassium hyaluronate based on the total weight.

The skin external composition according to an embodiment of the present invention contains caffeine, ginger extract, vanillin butyl ethyl, glycine, serine, glutamic acid, aspartic acid, leucine, alanine, lysine, arginine, Tyrosine, phenylalanine, threonine, proline, valine, isoleucine, histidine, cysteine, methionine, sodium hyaluronate, hydrolyzed hyaluronyl acid, hyaluronic acid, sodium hyaluronate crosspolymer, hydrochloride Rollized sodium hyaluronate and potassium hyaluronate are 14:14:2:2:2:2:2:2:2:2:2:2:2:2:2:2:2:2 :2:2:4.5:4.5:4.5:4.5:4.5:4.5:4.5:4.5 to 30:30:10:1:1:1:1:1:1:1:1:1:1:1:1 It is characterized in that it is included in a weight ratio of :1:1:1:1:1:1.625:1.625:1.625:1.625:1.625:1.625:1.625:1.625.

The composition for external application for skin according to an embodiment of the present invention contains 50% by weight of the total weight of purified water, glycerin, butylene glycol, and 1,2-hexanediol remaining on the skin for rapid transdermal absorption of the composition of the combination of active ingredients. It is preferable to contain 97% by weight. In addition, the composition for external application for skin according to an embodiment of the present invention contains the purified water, glycerin, butylene glycol, and 1.2-hexanediol in a ratio of 75:9:8:8 - 89:3:4:4 for rapid transdermal absorption. It is preferable to include it in weight ratio.

Butylene glycol helps extract the active ingredients from natural extracts, increases skin absorption, and stabilizes the formulation. It increases moisturizing power, softens the skin, and reduces viscosity.

1,2-Nucleic acid diol is widely used as a replacement ingredient due to controversy over the harmfulness of paraben preservatives. Although it has strong antibacterial properties, it is known to have little skin irritation or toxicity. Although it is not classified as a preservative, it is widely used as a preservative due to its strong antibacterial properties.

In addition, in order for the active ingredients to effectively penetrate the stratum corneum, epidermis, and dermis for swelling, warmth, blood circulation improvement, and ejaculation delay effects, polyglyceryl-10 laurate, diethylhexyl sodium sulfosuccinate, and olive oil glycerol are added. It is preferable that -8 ester is included in the range of 2% to 10% by weight relative to the total weight. The composition for external application for skin according to an embodiment of the present invention contains polyglyceryl-10 laurate, diethylhexyl sodium sulfosuccinate, and olive oil glycereth-8 ester for effective penetration of the active ingredients into the stratum corneum, epidermis, and dermis. It is preferable to include it in a weight ratio of 50:0.5:49.5 to 70:7:23.

The composition of the present invention is preferably formulated as a gel so that it has excellent spreadability on the skin and does not leave a sticky or slippery feeling after application. The composition of the present invention can be formulated into liquids and creams as well as gels.

Meanwhile, the results of the human application test for the external skin composition according to the embodiment of the present invention configured as described above are as follows. The human application test is a test to evaluate the efficacy of temporarily improving microscopic blood flow, and the report was published by the Korea Dermatological Research Institute on December 19, 2022. The number of study subjects was 21, and the test site was the forearm 15cm away from the wrist. The tester applied the test sample to the forearm once. Micro blood flow was evaluated using OMEGAZONE-2STD, and the safety of use was evaluated by a dermatologist.

The structures that make up the microcirculation system at the extremities of the skin include arterioles, venules, capillaries, and arteriovenous anastomosis, which are superficial (superficial) and deep (deep). It forms the structure of a vascular plexus. The factors that regulate microcirculatory flow are diverse and include local or spinal cord and central sympathetic nerve interactions due to physical factors and other endogenous vascular factors.

The skin is responsible for supplying nutrients to tissues, regulating body heat, exchanging metabolites, and maintaining tissue homeostasis through its microcirculatory system. When peripheral blood circulation disorders occur in certain diseases or abnormal conditions, the related abnormal symptoms are the cause of skin disease. It may also occur in the form

The method of evaluating the skin's peripheral blood circulation status is based on the domestic Ministry of Food and Drug Safety guidelines, using a skin micro-blood flow meter and skin chromameter to measure redness as evaluation indicators, and is conducted according to the skin blood circulation improvement evaluation test method.

OMEGAZONE, used as a micro blood flow measurement device, is a device that non-invasively and continuously obtains colored blood flow images of biological tissues with high resolution. It detects changes in the speckle pattern of moving red blood cells through laser irradiation, and detects speckle patterns according to the speed of moving particles. The speed of the particle is measured by measuring the spatiotemporal change in pattern intensity. OMEGAZONE's laser beam can reach a point of about 1 mm or less from the skin surface, and the electric field (E) fluctuates due to the sum of light scattered by moving red blood cells and the light intensity of the photodetector fluctuates accordingly. It can be said that the speed and size of the fluctuation are related to the speed and number density of red blood cells, respectively.

The results of measuring skin micro-blood flow in the test area using OMEGAZONE-2STD (OMEGAWAVE, INC., Japan) are as follows.

No. Before application After application One 8.49 10.96 2 9.74 11.81 3 8.56 11.64 4 9.16 10.62 5 7.01 10.72 6 6.61 11.11 7 5.53 6.62 8 8.04 8.95 9 6.49 8.17 10 8.81 12.42 11 8.40 9.44 12 7.96 13.22 13 10.03 15.85 14 7.64 8.20 15 12.62 13.76 16 6.93 10.93 17 8.48 9.39 18 6.66 10.29 19 8.66 9.24 20 7.70 8.93 21 7.48 9.84

<Blood Flow (ml/min/100g) measurement results>

Figure 1 is a graph comparing skin blood flow before and after application. It can be clearly seen that blood flow increased from an average of 8.14 before application to an average of 10.58 after application.

Measure skin micro-blood flow using OMEGAZONE-2STD before and after applying the sample to the test area, and calculate the skin micro-blood flow improvement rate as follows.

<Statistical results of microblood flow (ml/min/100g)>

It can be seen from Table 2 and Figure 2 above that the test area where the test sample was applied once showed a statistically significant increase in microblood flow compared to before sample application, showing that the test sample can help temporarily improve microblood flow. As shown in Figure 2, the improvement rate after application is 31.02%.

The results of the safety evaluation by a dermatologist are as follows.

- During the test period, evaluate whether side effects (erythema, swelling, scaling, itching, stinging, burning, stiffness, tingling, and other abnormalities) occurred due to the use of the sample.

<Skin abnormalities that occurred during the test period>

As confirmed in Table 3 above, no special abnormal symptoms occurred during the test period.

A test was conducted on 21 research subjects to evaluate the efficacy of a composition sample according to an embodiment of the present invention to improve temporary microscopic blood flow, and all 21 research subjects completed the test without any dropouts. The test results are as follows.

1) Blood Flow measurement value (ml/min/100g), which represents microscopic blood flow, increased by 31.02% after application compared to before application.

2) No special adverse reactions were observed in all study subjects during the test period.

In conclusion, the test area where the skin external preparation sample according to the embodiment of the present invention was applied once increased microscopic blood flow to a statistically significant level (p<0.05) compared to before application, and the test sample helped to temporarily improve microscopic blood flow. It is judged that it can be given. In addition, no special adverse reactions were observed in all study subjects, so it is considered a safe sample.

The results of the sensory evaluation of the external skin preparation according to the embodiment of the present invention are as follows.

The evaluation method is to apply the external skin preparation according to an embodiment of the present invention to the male genitalia, measure the circumference length before erection and measure the circumference length after erection, and repeat the measurement three times after 2 hours to evaluate the effect of increasing thickness. , the skin external preparation according to an embodiment of the present invention is applied to the male genitals and the time taken to ejaculate is measured to evaluate the effect of delaying ejaculation and to evaluate the formulation.

In Table 4, the three previous measurements were the glans circumference before and after erection without applying the sample and the ejaculation delay time during masturbation three times, and the average value was taken as the baseline. After applying the sample, the glans circumference and ejaculation delay time before and after erection were measured to determine the amount of change. The average value of repeating this three times is the value outside the parentheses. The values in parentheses are deviation values. Before erection, the average circumference change is 7.25%, and after erection, the circumference change is 3.52%. In other words, a temporary increase in volume can be confirmed. It can be seen that the delay time increases by an average of 22.68%.

The latter two measurement values are the results of scoring the warmth and swelling felt on the glans by the sample after application of the sample according to the provided quantitative evaluation standard. The value outside the parentheses is the average value obtained by evaluating this three times. The values in parentheses are deviation values. The average thermal sensation is 5.4 points, which confirms that it provides an appropriate thermal sensation without causing any unnecessary stimulation to sensitive areas. The sense of swelling had an average score of 5.225, and it was confirmed that a sense of swelling and warmth could be felt by applying the sample.

Table 5 shows the results of scoring each evaluation item according to the formulation evaluation index standards provided while applying the sample to the glans. The average value recorded after repeated evaluation three times is the value outside the parentheses, and the value inside the parentheses is the deviation value.

Figure 3 is a graph showing the degree of warmth felt as a result of applying the external skin composition according to an embodiment of the present invention to 30 test subjects, and Figure 4 is a graph showing the degree of swelling felt felt. The green line in Figures 3 and 4 is the test result of Example (a) containing 0.10% by weight of caffeine, 0.10% by weight of ginger extract, and 0.02% by weight of vanillin butyl ether, and the red line is 0.2% by weight of caffeine and ginger extract. This is the test result of Example (b) containing 0.2% by weight and 0.005% by weight of vanillin butyl ether. The overall test results for both the Example (a) sample and the Example (b) sample were satisfactory, but in the sample of Example (a), all evaluators felt a warm sensation, mainly a moderate warmth (44%), ranging from a mild to a slightly strong warmth. The number of people who felt the warmth was evenly distributed, 76% of the testers felt the swelling, only 4% felt the pain to the point of obstruction, and 72% of the testers felt the effect within 3 to 20 seconds after application. The result was that 72% of people felt that the drug effect lasted less than 10 to 30 minutes. Example (a) The response rate for swelling in the sample was 76%, which was far superior to Example (b), which was 44%, and the perceived warmth in Example (a) was even and oriented toward the right, resulting in a comprehensive evaluation. It can be confirmed that (a) produces the most optimal effect.

Claims (2)

In an external skin composition containing caffeine, ginger extract, and vanillyl butyl ether as active ingredients,
The caffeine contains 0.10% by weight, the ginger extract contains 0.10% by weight, and the vanillin butyl ether contains 0.02% by weight,
The composition further includes purified water, glycerin, butylene glycol, and 1,2-hexanediol, and the purified water, glycerin, butylene glycol, and 1,2-hexanediol are 50% by weight of the total weight. A composition for external application for skin that provides a feeling of swelling and warmth to the male genitals and improves blood circulation, characterized in that it contains from 97% by weight.
According to claim 1,
The purified water, glycerin, butylene glycol, and 1,2-hexanediol are included in a weight ratio of 75:9:8:8 to 89:3:4:4. Swelling and warmth in the male genitals. A composition for external use on the skin that improves blood circulation.