KR102550993B1 - Health functional food for improving bronchial function or enhancing immune function - Google Patents

Abstract

The health functional food of the present invention contains quince, licorice, jujube and bellflower as essential components, and thus has a very excellent effect of improving bronchial function or enhancing immune function. Effective substances contained in the health functional food of the present invention exert a synergistic effect to prevent bronchial diseases such as cough, phlegm, asthma, and bronchitis, as well as diseases caused by various immune deficiencies, such as environmental pollution, irregular lifestyle, and stress. It can be expected to be useful for modern people who are exposed to the risk of various respiratory diseases and immunodeficiency diseases due to

Description

Health functional food for improving bronchial function or enhancing immune function}

The present invention relates to a health functional food for improving bronchial function or enhancing immune function.

Particulate Matter (PM) refers to fine dust floating in the air for a long time, and particles with a diameter of 2.5 μm or less are classified as ultrafine dust. Due to rapid industrialization and industrialization in Korea over the past decades, the environment has been continuously deteriorating. Recently, China's high dependence on coal and rapid economic growth have continuously increased smog, resulting in frequent occurrence of fine dust. Fine dust containing harmful substances such as sulfur oxides, nitrogen oxides, and lead can penetrate into the human body through the respiratory tract and skin, causing respiratory system-related diseases such as decreased lung function, exacerbation of asthma, and occurrence of chronic bronchitis, and myocardial infarction. It is known to increase the incidence of cardiovascular-related diseases such as angina pectoris and arrhythmia (Kim Oh-shik et al., 2009, ReSEAT analysis report).

It is known that polycyclic aromatic hydrocarbon (PAH) contained in fine dust penetrates into cells and commonly activates aryl hydrocarbon receptor (AhR). Through the AhR activation mechanism, intracellular reactive oxygen species (ROS) are increased, and the expression of various inflammatory mediators is increased to cause respiratory diseases.

Due to the increase in respiratory diseases caused by fine dust worldwide, the World Health Organization (WHO) classified it as a group 1 carcinogen in 2013, and Korea is in dire need of a plan to reduce fine dust and the development of a treatment accordingly. Most respiratory disease treatments are single-component synthetic medicines. In the case of fine dust, conventional ingredients vary depending on regional, seasonal, seasonal, climate and environmental influences, so effective treatment for various pathological mechanisms is difficult. Therefore, it can be said that the development and research of treatments are important due to the social phenomenon in which the frequency of occurrence of fine dust is gradually increasing.

On the other hand, Liriope platyphylla is a perennial herbaceous plant belonging to the Liliaceae family that grows well in shady and humid places, blooms purple flowers in July and bears black fruits in October. It has been reported to have antiarrhythmic and anticancer effects. In addition, as the main active ingredient of Macmundong, it contains homoisoflavonids such as ophiopogenine A, B, methylophiopogonone A, B, ophiopogonanone A, methylophiopoginanone A, B, which are steroid saponins, and other β-sitosterol, stigmasterol, β-sitosterol glucoside, It has been reported that about 60% or more of various polysaccharides such as oligosaccharides are contained in tubers.

In addition, there is a need to prevent and treat respiratory diseases caused by fine dust, which is emerging as a social problem, by providing functional foods using beneficial components of natural products other than extracts of Macundong.

Korea Patent No. 2368682

An object of the present invention is to provide a health functional food for improving bronchial function or enhancing immune function.

The technical problem to be achieved by the present invention is not limited to the above-mentioned technical problem, and other technical problems not mentioned will be clearly understood by those skilled in the art from the following description.

As one aspect of the present invention, a health functional food for improving bronchial function or enhancing immune function, comprising an extract of a mixture including quince, licorice, jujube and bellflower, and further including schizandra chinensis, Schisandra chinensis, or a combination thereof provides

The term 'extract' has a meaning commonly used in the art as a crude extract, but also includes a fraction obtained by further fractionating the extract in a broad sense. That is, the extract used in the present invention includes not only those obtained by using an extraction solvent but also those obtained by additionally applying a purification process thereto. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatographies (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through various purification methods may also be included in the extract of the present invention. In addition, the extract may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying. Methods for obtaining the extract include, but are not limited to, leaching, stirring extraction, ultrasonic extraction, supercritical extraction, solvent extraction, alcohol extraction, and hot water extraction.

The extract is water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, diethyl ether, cyclohexane, and combinations thereof It may be extracted using a solvent selected from among.

The extract may be obtained by hot water extraction at a temperature of 80 to 150 °C for 30 minutes or more. Specifically, at a temperature of 80 to 150 ° C, 85 to 145 ° C, 90 to 140 ° C, 95 to 135 ° C, 100 to 130 ° C, 105 to 130 ° C or 110 to 120 ° C, 5 to 15 hours, 5 to 14 hour, 5 to 13 hours, 5 to 12 hours, 5 to 11 hours, 5 to 10 hours, 6 to 15 hours, 6 to 14 hours, 6 to 13 hours, 6 to 12 hours, 6 to 13 hours, 6 to 12 hours time, it may be hot water extraction for 6 to 11 hours or 6 to 10 hours.

The quince in the mixture 9 to 30, 9 to 29, 9 to 28, 9 to 27, 9 to 26, 9 to 25, 9 to 24, 9 to 23, 9 to 22, 9 to 21, 9 to 20, 9 to 19, 9 to 18, 9 to 17, 9 to 16, 9 to 15, 9 to 14, 10 to 30, 10 to 29, 10 to 28, 10 to 27, 10 to 26, 10 to 25, 10 to 24, 10 to 23, 10 to 22, 10 to 21, 10 to 20, 10 to 19, 10 to 18, 10 to 17, 10 to 16, 10 to 15, or 10 to 14% by weight, bronchial In terms of improving health and preventing headaches or dizziness due to excessive intake at the same time, according to a preferred embodiment, it may be included in 10 to 14% by weight, but is not limited thereto.

The licorice is 8 to 30, 8 to 29, 8 to 28, 8 to 27, 8 to 26, 8 to 25, 8 to 24, 8 to 23, 8 to 22, 8 to 21, 8 to 20, 8 to 19, 8 to 18, 8 to 17, 8 to 16, 8 to 15, 8 to 14, 8 to 13, 9 to 30, 9 to 29, 9 to 28, 9 to 27, 9 to 26, 9 to 25, 9 to 24, 9 to 23, 9 to 22, 9 to 21, 9 to 20, 9 to 19, 9 to 18, 9 to 17, 9 to 16, 9 to 15, 9 to 14 or 9 to 13 weight It may be included in %, and may be included in 9 to 13% by weight according to one preferred embodiment in terms of preventing the side effect of increasing blood pressure while properly containing the active ingredient glycyrrhizic acid, but is not limited thereto.

The jujube is 7 to 30, 7 to 29, 7 to 28, 7 to 27, 7 to 26, 7 to 25, 7 to 24, 7 to 23, 7 to 22, 7 to 21, 7 to 20, 7 to 19, 7 to 18, 7 to 17, 7 to 16, 7 to 15, 7 to 14, 7 to 13, 7 to 12, 8 to 30, 8 to 29, 8 to 28, 8 to 27, 8 to 26, 8 to 25, 8 to 24, 8 to 23, 8 to 22, 8 to 21, 8 to 20, 8 to 19, 8 to 18, 8 to 17, 8 to 16, 8 to 15, 8 to 14; It may be included in 8 to 13 or 8 to 12% by weight, and according to a preferred embodiment, it may be included in 8 to 12% by weight in terms of appropriately containing vitamin C and allowing a user with a hot constitution to take it without burden. It may be, but is not limited thereto.

The bellflower 6 to 30, 6 to 29, 6 to 28, 6 to 27, 6 to 26, 6 to 25, 6 to 24, 6 to 23, 6 to 22, 6 to 21, 6 to 20, 6 to 19 , 6 to 18, 6 to 17, 6 to 16, 6 to 15, 6 to 14, 6 to 13, 6 to 12, 6 to 11, 7 to 30, 7 to 29, 7 to 28, 7 to 27, 7 to 26, 7 to 25, 7 to 24, 7 to 23, 7 to 22, 7 to 21, 7 to 20, 7 to 19, 7 to 18, 7 to 17, 7 to 16, 7 to 15, 7 to 14 , 7 to 13, 7 to 12, or 7 to 11% by weight, and the active ingredient includes saponin in an appropriate amount to prevent hemolysis, and according to a preferred embodiment, 7 to 11% by weight It may include, but is not limited thereto.

The rhizomes do not specifically cover their leaves, stems, roots, seeds, fruits, etc., and according to a preferred embodiment, they may be their roots. 6 to 30, 6 to 29, 6 to 28, 6 to 27, 6 to 26, 6 to 25, 6 to 24, 6 to 23, 6 to 22, 6 to 21, 6 to 20, 6 to 19 , 6 to 18, 6 to 17, 6 to 16, 6 to 15, 6 to 14, 6 to 13, 6 to 12, 6 to 11, 7 to 30, 7 to 29, 7 to 28, 7 to 27, 7 to 26, 7 to 25, 7 to 24, 7 to 23, 7 to 22, 7 to 21, 7 to 20, 7 to 19, 7 to 18, 7 to 17, 7 to 16, 7 to 15, 7 to 14 , 7 to 13, 7 to 12, or 7 to 11% by weight, in terms of preventing abdominal pain or diarrhea due to excessive intake while improving bronchial and lung health, according to a preferred embodiment, 7 to 11 It may be included in weight percent, but is not limited thereto.

The Schizandra chinensis does not particularly cover its leaves, stems, roots, seeds, fruits, etc., and may be its fruit according to a preferred embodiment. The Schizandra chinensis 6 to 30, 6 to 29, 6 to 28, 6 to 27, 6 to 26, 6 to 25, 6 to 24, 6 to 23, 6 to 22, 6 to 21, 6 to 20, 6 to 19 , 6 to 18, 6 to 17, 6 to 16, 6 to 15, 6 to 14, 6 to 13, 6 to 12, 6 to 11, 7 to 30, 7 to 29, 7 to 28, 7 to 27, 7 to 26, 7 to 25, 7 to 24, 7 to 23, 7 to 22, 7 to 21, 7 to 20, 7 to 19, 7 to 18, 7 to 17, 7 to 16, 7 to 15, 7 to 14 , 7 to 13, 7 to 12, or 7 to 11% by weight, in terms of alleviating the representative symptoms of respiratory diseases and allowing people with poor health to take it without burden, in one preferred embodiment When followed, it may be included in 7 to 11% by weight, but is not limited thereto.

The mixture may further include deodeok, small beans, or a combination thereof.

The deodeok is 4 to 30, 4 to 29, 4 to 28, 4 to 27, 4 to 26, 4 to 25, 4 to 24, 4 to 23, 4 to 22, 4 to 21, 4 to 20, 4 to 19 , 4 to 18, 4 to 17, 4 to 16, 4 to 15, 4 to 14, 4 to 13, 4 to 12, 4 to 11, 4 to 10, 4 to 9, 5 to 30, 5 to 29, 5 to 28, 5 to 27, 5 to 26, 5 to 25, 5 to 24, 5 to 23, 5 to 22, 5 to 21, 5 to 20, 5 to 19, 5 to 18, 5 to 17, 5 to 16 , 5 to 15, 5 to 14, 5 to 13, 5 to 12, 5 to 11, 5 to 10, or 5 to 9% by weight, considering the content of saponin contained in bellflower, an appropriate amount of additional saponin In terms of supplying, according to a preferred embodiment, it may be included in 5 to 9% by weight, but is not limited thereto.

The beans are 4 to 30, 4 to 29, 4 to 28, 4 to 27, 4 to 26, 4 to 25, 4 to 24, 4 to 23, 4 to 22, 4 to 21, 4 to 20, 4 to 19 , 4 to 18, 4 to 17, 4 to 16, 4 to 15, 4 to 14, 4 to 13, 4 to 12, 4 to 11, 4 to 10, 4 to 9, 5 to 30, 5 to 29, 5 to 28, 5 to 27, 5 to 26, 5 to 25, 5 to 24, 5 to 23, 5 to 22, 5 to 21, 5 to 20, 5 to 19, 5 to 18, 5 to 17, 5 to 16 , 5 to 15, 5 to 14, 5 to 13, 5 to 12, 5 to 11, 5 to 10, or 5 to 9% by weight, improving symptoms such as rhinitis or allergies and poor health of the large intestine at the same time In terms of allowing even non-skilled people to take it without burden, according to a preferred embodiment, it may be included in 5 to 9% by weight, but is not limited thereto.

The mixture may further include peppermint, triticale, or a combination thereof.

The peppermint does not particularly cover parts such as leaves, stems, roots, seeds, and fruits of the peppermint tree, and according to a preferred embodiment, it may be its leaves. The mint is 3 to 30, 3 to 29, 3 to 28, 3 to 27, 3 to 26, 3 to 25, 3 to 24, 3 to 23, 3 to 22, 3 to 21, 3 to 20, 3 to 19 , 3 to 18, 3 to 17, 3 to 16, 3 to 15, 3 to 14, 3 to 13, 3 to 12, 3 to 11, 3 to 10, 3 to 9, 3 to 8, 4 to 30, 4 to 29, 4 to 28, 4 to 27, 4 to 26, 4 to 25, 4 to 24, 4 to 23, 4 to 22, 4 to 21, 4 to 20, 4 to 19, 4 to 18, 4 to 17 , 4 to 16, 4 to 15, 4 to 14, 4 to 13, 4 to 12, 4 to 11, 4 to 10, 4 to 9 or 4 to 8% by weight, all similar to cough caused by a cold In terms of alleviating symptoms and at the same time allowing people suffering from reflux esophagitis to take it without burden, according to a preferred embodiment, it may be included in 4 to 8% by weight, but is not limited thereto.

The 300 seconds does not specifically cover its leaves, stems, roots, seeds, fruits, etc., and according to a preferred embodiment, it may be its leaves. 3 to 30, 3 to 29, 3 to 28, 3 to 27, 3 to 26, 3 to 25, 3 to 24, 3 to 23, 3 to 22, 3 to 21, 3 to 20, 3 to 19 , 3 to 18, 3 to 17, 3 to 16, 3 to 15, 3 to 14, 3 to 13, 3 to 12, 3 to 11, 3 to 10, 3 to 9, 3 to 8, 4 to 30, 4 to 29, 4 to 28, 4 to 27, 4 to 26, 4 to 25, 4 to 24, 4 to 23, 4 to 22, 4 to 21, 4 to 20, 4 to 19, 4 to 18, 4 to 17 , 4 to 16, 4 to 15, 4 to 14, 4 to 13, 4 to 12, 4 to 11, 4 to 10, 4 to 9 or 4 to 8% by weight may be included, while improving various inflammatory reactions In terms of preventing diarrhea due to excessive intake, according to a preferred embodiment, it may be included in 4 to 8% by weight, but is not limited thereto.

The mixture may further include ginger, elm bark, or a combination thereof.

The ginger is 2 to 30, 2 to 29, 2 to 28, 2 to 27, 2 to 26, 2 to 25, 2 to 24, 2 to 23, 2 to 22, 2 to 21, 2 to 20, 2 to 19 , 2 to 18, 2 to 17, 2 to 16, 2 to 15, 2 to 14, 2 to 13, 2 to 12, 2 to 11, 2 to 10, 2 to 9, 2 to 8, 2 to 7, 3 to 30, 3 to 29, 3 to 28, 3 to 27, 3 to 26, 3 to 25, 3 to 24, 3 to 23, 3 to 22, 3 to 21, 3 to 20, 3 to 19, 3 to 18 , 3 to 17, 3 to 16, 3 to 15, 3 to 14, 3 to 13, 3 to 12, 3 to 11, 3 to 10, 3 to 9, 3 to 8 or 3 to 7% by weight, and , In terms of strengthening the immune function through the active ingredient contained in ginger and preventing excessive stimulation of the stomach at the same time, according to a preferred embodiment, it may be included in 3 to 7% by weight, but is not limited thereto.

The elm bark is 2 to 30, 2 to 29, 2 to 28, 2 to 27, 2 to 26, 2 to 25, 2 to 24, 2 to 23, 2 to 22, 2 to 21, 2 to 20, 2 to 19, 2 to 18, 2 to 17, 2 to 16, 2 to 15, 2 to 14, 2 to 13, 2 to 12, 2 to 11, 2 to 10, 2 to 9, 2 to 8, 2 to 7 , 3 to 30, 3 to 29, 3 to 28, 3 to 27, 3 to 26, 3 to 25, 3 to 24, 3 to 23, 3 to 22, 3 to 21, 3 to 20, 3 to 19, 3 to 18, 3 to 17, 3 to 16, 3 to 15, 3 to 14, 3 to 13, 3 to 12, 3 to 11, 3 to 10, 3 to 9, 3 to 8 or 3 to 7% by weight. In terms of effectively improving allergic reactions and preventing side effects on the liver due to excessive intake at the same time, according to a preferred embodiment, it may be included in 3 to 7% by weight, but is not limited thereto.

The mixture may further include ganoderma lucidum.

The ganoderma lucidum is 1 to 30, 1 to 29, 1 to 28, 1 to 27, 1 to 26, 1 to 25, 1 to 24, 1 to 23, 1 to 22, 1 to 21, 1 to 20, 1 to 19, 1 to 18, 1 to 17, 1 to 16, 1 to 15, 1 to 14, 1 to 13, 1 to 12, 1 to 11, 1 to 10, 1 to 9, 1 to 8, 1 to 7, 1 to 6, 2 to 30, 2 to 29, 2 to 28, 2 to 27, 2 to 26, 2 to 25, 2 to 24, 2 to 23, 2 to 22, 2 to 21, 2 to 20, 2 to 19, 2 to 18, 2 to 17, 2 to 16, 2 to 15, 2 to 14, 2 to 13, 2 to 12, 2 to 11, 2 to 10, 2 to 9, 2 to 8, 2 to 7 or It may be included in 2 to 6% by weight, in terms of improving bronchial health and at the same time preventing side effects of constipation caused by excessive intake, according to a preferred embodiment, it may be included in 2 to 6% by weight, but is limited thereto no.

The health functional food can be manufactured and processed into food in the form of tablets, capsules, powders, granules, liquids, pills, and the like.

The health functional food may be manufactured and processed using raw materials or ingredients having useful functionalities for the human body according to the Health Functional Food Act No. 6727, which regulates nutrients for the structure and function of the human body. It refers to intake for the purpose of obtaining useful effects for health purposes, such as health or physiological actions.

The health functional food may contain normal food additives, and the suitability as a food additive is determined according to the general rules and general test methods of food additives approved by the Korea Food and Drug Administration, unless otherwise specified. judged by criteria.

Items listed in the Food Additives Codex include, for example, chemical compounds such as ketones, glycine, calcium citrate, nicotinic acid, and cinnamic acid; natural additives such as persimmon pigment, licorice extract, crystalline cellulose, kaoliang pigment, and guar gum; It includes, but is not limited to, mixed preparations such as sodium L-glutamate preparations, noodle-added alkali preparations, preservative preparations, and tar color preparations.

For example, a health functional food in the form of a tablet is obtained by granulating a mixture obtained by mixing the active substance with an excipient, a binder, a disintegrant, and other additives in a conventional manner, and then compression molding by adding a lubricant or the like, or It can be directly compression molded. In addition, the health functional food in the form of a tablet may contain a flavoring agent and the like as needed.

Among health functional foods in the form of capsules, hard capsules can be prepared by filling ordinary hard capsules with a mixture of the peptide of the present invention mixed with additives such as excipients, and soft capsules are prepared by mixing the active substances with additives such as excipients. It can be prepared by filling the mixture into a capsule base such as gelatin. The soft capsule may contain a plasticizer such as glycerin or sorbitol, a colorant, a preservative, and the like, if necessary.

The health functional food in the form of a pill can be prepared by molding a mixture of the above active substances, excipients, binders, disintegrants, etc. by a conventionally known method, and, if necessary, can be coated with sucrose or other coating agents, or The surface can also be coated with a material such as starch or talc.

Health functional food in the form of granules can be prepared in a granular form by a conventionally known method of a mixture of the above active substances, excipients, binders, disintegrants, etc., and may contain flavoring agents, flavoring agents, etc., if necessary. .

The health functional food is beverages, meat, chocolate, foods, confectionery. It may be pizza, ramen, other noodles, chewing gum, candy, ice cream, alcoholic beverages, vitamin complexes and health supplements.

The health functional food of the present invention contains quince, licorice, jujube and bellflower as essential components, and thus has a very excellent effect of improving bronchial function or enhancing immune function.

However, it should be understood that it is not limited to the above effects, and includes all effects that can be inferred from the configuration of the invention described in the detailed description or claims.

Hereinafter, an example will be described in detail for a more detailed explanation. However, the following examples are illustrative, and the scope of the present invention is not limited thereto.

Example. Manufacture of health functional food of the present invention

For the production of the health functional food of the present invention, 120 g of quince, 110 g of licorice, 100 g of jujube, 90 g of bellflower root, 90 g of root of Schisandra chinensis, 90 g of fruit of Schisandra chinensis, 70 g of deodeok, 70 g of soybean, 60 g of mint leaf, 60 g of Sambaekcho, 50 g of ginger, 50 g of elm bark and 40 g of ganoderma lucidum was prepared by washing. 10 L of water was used as an extraction solvent.

Thereafter, 10L of water, 120g of Chinese quince, 110g of licorice, 100g of jujube, 90g of bellflower root, and 90g of root of rhododendron were placed in a water heater and extracted at 120° C. for 8 hours to prepare the health functional food of the present invention (Example 1).

In addition, 10L of water and 120g of Chinese quince, 110g of licorice, 100g of jujube, 90g of bellflower root, 90g of root of Schisandra chinensis, and 90g of fruit of Schisandra chinensis were placed in a water heater and extracted at 120° C. for 8 hours to prepare the health functional food of the present invention (Example 2 ).

In addition, 10 L of water and 120 g of quince, 110 g of licorice, 100 g of jujube, 90 g of bellflower root, 90 g of root of Schisandra chinensis, 90 g of fruit of Schizandra chinensis, and 70 g of deodeok were placed in a water heater and extracted at 120 ° C. for 8 hours to prepare the health functional food of the present invention ( Example 3).

In addition, 10L of water and 120g of quince, 110g of licorice, 100g of jujube, 90g of bellflower root, 90g of root of Schisandra chinensis, 90g of fruit of Schizandra chinensis, 70g of deodeok and 70g of soybean were put in a water heater and extracted at 120°C for 8 hours to obtain the health functional food of the present invention. prepared (Example 4).

In addition, 10L of water and 120g of quince, 110g of licorice, 100g of jujube, 90g of bellflower, 90g of rhubarb root, 90g of Schisandra chinensis fruit, 70g of deodeok, 70g of green bean and 60g of mint leaf were put in a water heater, and extracted at 120° C. for 8 hours to extract the present invention. A health functional food was prepared (Example 5).

In addition, 10L of water, 120g of quince, 110g of licorice, 100g of jujube, 90g of bellflower, 90g of rhubarb root, 90g of Schisandra chinensis fruit, 70g of deodeok, 70g of green bean, 60g of mint leaves and 60g of Sambaekcho were put in a water heater and extracted at 120°C for 8 hours. Thus, the health functional food of the present invention was prepared (Example 6).

In addition, 10L of water and 120g of quince, 110g of licorice, 100g of jujube, 90g of bellflower root, 90g of macmundong root, 90g of Schizandra fruit, 70g of deodeok, 70g of soybean, 60g of mint leaf, 60g of Sambaekcho, and 50g of ginger were put in a water heater, and 8 at 120 ° C. The health functional food of the present invention was prepared by extraction for a period of time (Example 7).

In addition, 10L of water, 120g of quince, 110g of licorice, 100g of jujube, 90g of bellflower root, 90g of root of Schisandra chinensis, 90g of fruit of Schisandra chinensis, 70g of deodeok, 70g of soybean, 60g of mint leaves, 60g of sambaccho, 50g of ginger and 50g of elm bark were put in a water heater , The health functional food of the present invention was prepared by extraction at 120 ° C. for 8 hours (Example 8).

In addition, 10L of water and quince 120g, licorice 110g, jujube 100g, bellflower 90g, macmundong root 90g, omija fruit 90g, deodeok 70g, soy bean 70g, mint leaf 60g, sachincho 60g, ginger 50g, elm bark 50g, and ganoderma lucidum 40g was placed in a water heater and extracted at 120 ° C. for 8 hours to prepare the health functional food of the present invention (Example 9).

Experimental Example 1. Evaluation of bronchial function improvement efficacy

For Examples 1 to 9, a total of 180 people, 20 each of allergic rhinitis patients, smokers, and bronchial disease subjects, were allowed to drink 1 pack 2-3 times a day for 3 months, and rhinitis, sputum and bronchus depending on the degree of each person's feeling 9-point scoring method (9: almost complete cure, 7: good significant improvement, 5: some improvement, 3: insignificant improvement) for the improvement effect of function (cough frequency) No effect) was evaluated using, and the results are shown in Table 1 below.

division Rhinitis sputum tracheal function
(cough frequency) Example 1 6.2 6.6 6.7 Example 2 7.1 6.6 6.8 Example 3 7.5 7.7 7.3 Example 4 8.0 7.7 7.5 Example 5 7.9 7.8 8.1 Example 6 7.8 8.1 8.5 Example 7 8.1 8.2 8.3 Example 8 8.5 8.2 8.3 Example 9 8.5 8.7 9.0

As shown in Table 1, in the case of Examples 1 to 9 of the health functional food of the present invention, it can be confirmed that there is a significant improvement effect on rhinitis, phlegm removal, and bronchial function (cough frequency). In particular, in the case of Example 9, it can be seen that the improvement effect due to the synergy between active substances is very excellent, considering that an evaluation close to a complete cure was obtained in terms of cough frequency.

Therefore, the active substances contained in the health functional food of the present invention exert a synergistic effect to modern people who are exposed to the risk of various respiratory diseases due to environmental pollution, irregular lifestyle, and stress such as cough, sputum, asthma, bronchitis, etc. It can be expected that it will be useful.

Experimental Example 2. Immunity enhancement efficacy evaluation

For the experiment, 50 ICR mice (6 weeks old, male, 23-28g) were purchased, and regular feed (Altromin, Germerny) was freely fed for one week, and sufficient water was supplied to send a stable period. Immunosuppression was induced by injecting 100 μl of an immunosuppressant (cyclophosphamide) into the abdominal cavity of each 7-week-old ICR mouse at a concentration of 150 mg/kg on the start day and 3 days after the start of the experiment. The experiment was conducted for a total of 14 days, and ICR mice were divided into 11 groups, and each composition was orally administered at a dose of 200 mg/kg once a day at 2:00 pm using an Oral zonde as shown in Table 2 below. .

division group condition Normal group 1 group (5 animals) No administration of immunosuppressants Administration of distilled water control group 2 groups (5 animals) Administration of immunosuppressive agents Administration of distilled water Example 1 3 groups (5 animals) Administration of immune agents Example 1 Administration Example 2 4 groups (5 animals) With administration of immune agents Example 2 Administration Example 3 5 groups (5 animals) Administration of immune agents Example 3 Administration Example 4 6 groups (5 animals) Administration of immune agents Example 4 Administration Example 5 7 groups (5 animals) Administration of immune agents Example 5 administration Example 6 8 groups (5 animals) Administration of immune agents Example 6 Administration Example 7 9 groups (5 animals) With administration of immune agents Example 7 Administration Example 8 10 groups (5 dogs) Administration of immune agents Example 8 Administration Example 9 11 groups (5 animals) Administration of immune agents Example 9 Administration

After the experiment was completed, blood was collected using the cardiac puncture method, solidified at room temperature for 30 minutes, centrifuged at 3,000 rpm for 15 minutes, and the separated serum and standard were dispensed in 50 μl each in a 96-well plate and anti-mouse nulti-immunoglobulin beads 25 μl each was added and mixed, reacted at room temperature for 15 minutes while blocking light, and washed twice using a washing buffer solution. Thereafter, 25 μl of anti-mouse light chaim, PE was added and reacted at room temperature for 15 minutes while blocking light, and 150 μl of PBS was added, mixed for 5 minutes, and immunoglobulins were measured using Luminex. The experimental results were statistically processed using the independent two-sample t-test of SPSS 24.0, and the results are shown in Table 3 below.

division IgA level
(pg/ml) IgG level
(pg/ml) IgM level
(pg/ml) Normal group 250 215 85 control group 80 40 35 Example 1 150 75 55 Example 2 155 79 56 Example 3 158 84 56 Example 4 165 87 57 Example 5 169 95 59 Example 6 173 99 61 Example 7 179 103 65 Example 8 181 110 71 Example 9 189 120 76

Referring to Table 3, it can be confirmed that a significant increase in immune cells appeared in the groups to which the compositions of Examples 1 to 9 were administered. In particular, it can be confirmed that Example 9 showed the highest increase.

The scope of the present invention is indicated by the following claims, and all changes or modifications derived from the meaning and scope of the claims and equivalent concepts should be interpreted as being included in the scope of the present invention.

Claims (5)

Contains extracts of quince, licorice, jujube, bellflower, rhubarb, schizandra, deodeok, soy bean, mint leaf, triticale, ginger, elm bark and ganoderma lucidum mixture,
11 to 13% by weight of the total weight of the quince, 10 to 12% by weight of licorice, 9 to 11% by weight of jujube, 8 to 10% by weight of bellflower, 8 to 10% by weight of quince root, 8 to 10% by weight of Schisandra fruit %, deodeok 6 to 8% by weight, soybean 6 to 8% by weight, mint leaves 5 to 7% by weight, Sambaekcho 5 to 7% by weight, ginger 4 to 6% by weight, elm bark 4 to 6% by weight, and Ganoderma lucidum 3 to 5% by weight,
Health functional food for improvement of bronchial function or enhancement of immune function.
The health functional food according to claim 1, which is for improving bronchial function. delete delete delete