KR102542300B1 - Soft transparent patch with a two-layer structure using a thermoplastic elastomer gel composition - Google Patents

Abstract

In the present invention, the outer layer that is not attached to the skin and is exposed to the outside forms an active ingredient layer containing ingredients such as UV protection and has no adhesiveness instead of a support, and the inner layer that is directly attached to the skin has adhesiveness and has anti-wrinkle, whitening, etc. A thermoplastic elastomer with excellent elongation function that moves with muscle movement by forming a patch with a multi-layered structure having two transparent and soft fat-soluble gel active ingredient layers without a support. It is to provide a soft transparent patch having a two-layer structure using a gel composition.

Description

Soft transparent patch with a two-layer structure using a thermoplastic elastomer gel composition}

The present invention relates to a soft transparent patch, and more particularly, to a patch attached to the skin, which has a multi-layer structure of a layer that is directly attached to the skin without using a back layer and a layer that is exposed to the outside without being attached to the skin. The present invention relates to a soft transparent patch having a two-layer structure using a thermoplastic elastomer gel composition, wherein the patch is composed of only two transparent active ingredient layers without a support and thus has an excellent stretching function.

Patch products are expanding due to convenience and usefulness ranging from cosmetics, medical devices, quasi-drugs, pharmaceuticals, and industrial products. For example, patch products, such as patch, mask pack, and body pack, which are used by attaching to wounds or painful parts of the face or body, necessarily have a back layer on a layer exposed to the outside. Such a support is made of textile fabrics such as polyester, nylon, non-woven fabric, polyurethane film, or silicone, and is impregnated by coating or applying a gel and an adhesive containing active ingredients suitable for the purpose of use of the patch to one side of the support. The patch is manufactured by forming an adhesive layer on the inner surface of the supporter. The supporter protects the adhesive layer containing the active ingredient and prevents the adhesive layer from being contaminated by external dust or contact objects or clothes. . Therefore, it was a matter of course that the support was provided on the outer surface exposed to the outside of the patch.

Thus far, a support has been essentially provided on the outer surface of the patch, but since an adhesive layer containing an active ingredient is coated or coated on one side of the support made of an inflexible material such as a non-woven fabric or film and impregnated, the wrinkled area , If the patch is attached to a part that bends like a joint in the body, such as the knee, neck, elbow, or ankle, or if the patch is attached to the face, etc. Because of the resistance, the patch does not move like the movement of the muscles, so the adhesive layer separates from the skin, and the patch is separated from the skin. Also, when a patch with a support is attached, a foreign body feeling that something is being attached is felt, which is uncomfortable and reduces wearing comfort. has a problem

Looking at the technologies that have emerged regarding patches, Patent Registration No. 1983695 "Eye patch using skin temperature sensitive functional hydrogel composition with wrinkle improvement and whitening function and manufacturing method thereof", Patent Registration No. 1494407 "Skin temperature sensitive type A patch for improving blemishes using a hydrogel and a method for manufacturing the same" are all applied with a gel composition on one side of a stretchable sheet or film, and have the same problems as the patch with the support pointed out above.

On the other hand, when the gel contained in the adhesive layer is implemented as a water-soluble material, there is a problem that the effectiveness is reduced and the use is limited because the active ingredient evaporates easily over time after attaching the patch to the skin. In addition, sunscreens are commercialized in the form of creams or sticks, and since they are products that are applied directly to the face or body, white cast occurs and is easily washed off with water, so they must be applied frequently. there is. In addition, in the case of attaching a patch with a support, since the sunscreen cannot be directly applied to the support, the support fabric, such as a nonwoven fabric or film, must rely on the UV blocking ability of the material itself, so there is a problem in the actual UV blocking effect.

The present invention has been devised to solve the above problems, and an object of the present invention is to form an active ingredient layer containing ingredients such as UV protection and no adhesive strength instead of a support in the outer layer exposed to the outside without adhering to the skin. and the inner layer that is directly attached to the skin is formed with an active ingredient layer that has adhesiveness and contains ingredients for wrinkle improvement and whitening, so that the patch is composed of a multi-layered structure having two transparent and soft fat-soluble gel active ingredient layers without a support. It is to provide a soft transparent patch having a two-layer structure using a thermoplastic elastomer gel composition having an excellent elongation function that moves with muscle movement.

A soft transparent patch having a two-layer structure using a thermoplastic elastomer gel composition according to the present invention includes a first active ingredient layer containing an adhesive resin, oil, and a first active ingredient in a base polymer; a second active ingredient layer positioned outside the first active ingredient layer and containing oil and a second active ingredient in a base polymer; It is located on the inside of the first active ingredient layer and the outside of the second active ingredient layer, respectively, and is composed of first and second release papers to be removed and attached when attached to the skin, the first active ingredient layer, 7 to 20 parts by weight of a base polymer using any one of SEBS (Styrene Ethylene Butylene Styrene), SEPS (Styrene-ethylene-propylene-styrene) or SEEPS (Styrene Ethylene Ethylene Propylene Styrene); 20 to 40 parts by weight of adhesive resin; 40 to 77 parts by weight of oil; 0.5 to 5 parts by weight of the first active ingredient, and the second active ingredient layer comprises 10 to 25 parts by weight of a base polymer using any one of SEBS, SEPS or SEEPS; 70 to 85 parts by weight of oil; It is characterized by a composition comprising 5 to 25 parts by weight of the second active ingredient.

Preferably, a hydrogenated hydrocarbon resin among C5 or C9 hydrocarbon resins is used as the adhesive resin.

Preferably, any one of hydrogenated polydecene, squalane, and liquid paraffin is used as the oil.

Preferably, the first active ingredient is a whitening ingredient or an anti-wrinkle ingredient, and as the whitening ingredient, any one of alpha-bisabolol, oil-soluble licorice extract, and ascorbyl tetraisopalmitate is used, and the wrinkle-improving ingredient is retinol or retinol. Either of Nyl Palmitate is used.

Preferably, the second active ingredient is a sunscreen ingredient, and the sunscreen ingredient is any one of titanium dioxide (TiO ₂ ) and zinc oxide (ZincOxide), which are inorganic sunscreens, or avobenzone, oxybenzone, octo, which are organic sunscreens. Any one of krylene, homosalate, octisalate, octinosate, and ethylhexylmethoxycinnamate is used.

In the soft transparent patch according to the present invention, the outer layer exposed to the outside without adherence to the skin is formed of an active ingredient layer containing sunscreen and the like without adhesiveness instead of a support, and the inner layer directly adhered to the skin has adhesive strength and improves wrinkles. It is formed of active ingredient layers containing ingredients and/or whitening ingredients, etc., and the patch is composed of a multi-layered structure with two transparent and soft oil-soluble gel active ingredient layers without a support, so it is transparent because it has excellent stretching function. Even if the patch is attached to the joint or face, the patch moves along with the movement of the muscles, so you can feel as natural as not attaching the patch.

In addition, the transparent patch is formed in a multi-layer structure, so that ingredients that can irritate or harm the skin are contained in the outer layer (second active ingredient layer) to avoid direct contact with the skin, and ingredients harmless to the human body are directly applied to the skin It is formed to be contained in the inner layer (first active ingredient layer) in contact with the skin, and as a whole, a transparent and soft gel is used, so it looks natural when the patch is attached, and even when cosmetics are applied to the outer layer, it does not show at all and does not show makeup on the skin. As it is natural, it is a structure that enhances the safety of the user and enhances the convenience of use.

In addition, since the oil-soluble gel is used, the active ingredients are not washed away even when the patch comes in contact with water, and it does not evaporate, so it can be attached for a long time (more than 10 hours), and it can be attached to the face and applied to the outer layer of the patch, so the patch is attached. There is no problem with skin safety because the outer layer contains sunscreen ingredients so that the sunscreen does not come into direct contact with the skin.

1 is a cross-sectional view of a transparent patch according to the present invention.

The technical feature of the soft transparent patch according to the present invention is that the patch does not use a nonwoven fabric or film support, and the outer layer exposed to the outside is formed of an active ingredient layer containing sunscreen without adhesive strength, and is directly attached to the skin. The inner layer is composed of an active ingredient layer that is adhesive and contains wrinkle-improving ingredients or whitening ingredients, so that it has an excellent stretching function while forming a multi-layered structure consisting of two transparent oil-soluble gel active ingredient layers.

In the specification of the present invention, 'outer' or 'outer layer' refers to the side exposed to the outside when the patch is attached to the human body, and 'inner' or 'inner layer' refers to the side attached to the skin when the patch is attached to the human body. point out in advance.

The transparent patch (10) according to the present invention is used by attaching and detaching directly to the skin, and includes a first active ingredient layer (11) containing an ingredient that has adhesive strength and acts on the skin to produce a good effect, and is non-adhesive to the skin. First and second release papers (13, 13'). Therefore, the first active ingredient layer 11 attached to the skin is not provided with a support impregnated by being coated or applied, and instead of the support, the second active ingredient layer 12 made of a soft gel with good elongation is provided, so that the knee, ankle, Even when attached to the elbow, face, etc., it has strong adhesion, excellent wearing comfort, and it moves along with the movement of muscles, so it does not feel different at all.

The first active ingredient layer 11 is a layer having adhesiveness because it is attached to and detached from the skin, and is a layer containing an adhesive resin, oil, and the first active ingredient in a base polymer. The first active ingredient layer 11 includes 7 to 20 parts by weight of a base polymer using any one of SEBS (Styrene Ethylene Butylene Styrene), SEPS (Styrene-ethylene-propylene-styrene) or SEEPS (Styrene Ethylene Ethylene Propylene Styrene); 20 to 40 parts by weight of adhesive resin; It is composed of 0.5 to 5 parts by weight of the first active ingredient in a thermoplastic elastomer (TPE, hereinafter referred to as 'TPE') gel composed of 40 to 77 parts by weight of oil. A composition including such a TPE gel is attached to the skin of the human body, is quickly absorbed into the skin, and serves to continuously elute components over a certain period of time.

The TPE gel used in the present invention is composed of a base polymer, which is a block polymer, an adhesive resin that imparts adhesive strength, and an oil that gives a soft and moist feeling of wearing. The TPE gel of the present invention has a glass transition temperature (-72 ° C) similar to that of natural rubber, so it has the properties of a soft gel at room temperature and begins to liquefy at a high temperature of 100 ° C or higher. Therefore, when used at room temperature, it is always moist and comfortable to wear.

The block polymer used as the base polymer uses any one of styrene-based SEBS, SEPS, or SEEPS. SEBS, SEPS, and SEEPS are block polymers that are safe to the human body and have excellent mechanical properties, and are often used as raw materials for pharmaceuticals and cosmetics. am. In particular, SEBS, SEPS, and SEEPS are softer, transparent, and have better cohesion than other styrenic block polymers, so they are suitable for patches that do not leave residues on the skin when they are attached to the skin and then removed.

The adhesive resin is used among C5 or C9 hydrocarbon resins having excellent compatibility with SEBS, SEPS, and SEEPS. Preferably, hydrogenated hydrocarbon resin is used to secure excellent adhesive strength. More preferably, hydrogenated hydrocarbon resins are used that are approved by the US FDA as food wraps and food labels or have CAS numbers listed in INCI (International Nomenclature of Cosmetic Ingredients).

As the oil, any one of hydrogenated polydecene, squalane, and liquid paraffin, which are non-polar oils, is used. The patch of the present invention, which is composed of only active ingredient layers having a multi-layer structure, consists of each layer and has an appropriate thickness to give a soft feel, but is non-polar. Oil is suitable for this structure. Since these oils do not evaporate at room temperature, the active ingredients remain intact even after time elapses after manufacture or without sealing, and it enables the moist texture of the gel to be maintained. The appropriate thickness of the patch is preferably about 1 to 50 μm for one active ingredient layer of TPE gel, and about 2 to 100 μm for two active ingredient layers. When the thickness is greater than this, the patch looks prominent when attaching the patch and adversely affects adhesion.

The formulated formulation as described above has the properties of PressureSensitive Adhesives (PSA) due to the structure of both end-blocks of polystyrene and the rubber-block in the middle of SEBS, SEPS or SEEPS, and It has a transition temperature of -72℃, similar to that of natural rubber, and maintains a soft, soft gel at room temperature.

The first active ingredient layer (11) with adhesiveness is a layer that comes in contact with the skin and is applied directly to the human body to see the effect. Active ingredients for various purposes, such as natural ingredients such as capsaicin and glucosamine, or non-narcotic analgesic ingredients, as well as ingredients for reducing body fat, antioxidant ingredients, and so on, can be used. As the whitening ingredient, fat-soluble ingredients such as alpha-bisabolol, oil-soluble licorice extract, and ascorbyl tetraisopalmitate may be used. In addition, as an anti-wrinkle component, oil-soluble components such as retinol and retinyl palmitate may be used.

The second active ingredient layer 12 is located on the outside of the first active ingredient layer 11 and exposed to the outside, and is a smooth layer without adhesiveness because it does not adhere to the skin. The layer 12 has no adhesiveness even when exposed to the outside and is soft like the skin, so there is no inconvenience in use and it also serves to protect the active ingredients of the first active ingredient layer 11 having adhesiveness.

The second active ingredient layer 12 is a layer containing oil and a second active ingredient in a base polymer, 10 to 25 parts by weight of a base polymer using any one of SEBS, SEPS or SEEPS; 70 to 85 parts by weight of oil; It is composed of 5 to 25 parts by weight of the second active ingredient. Since it has no adhesive power, it does not contain adhesive resin among the active ingredients, and since the patch is exposed to the outside without touching the skin when the patch is attached to the skin, the second active ingredient may be harmful to the skin, but contains a component with a clear purpose for use. Ingredients that can be safely effective are used, such as sunscreen and sunblock ingredients.

As the sunscreen component, an inorganic sunscreen agent or an organic sunscreen agent may be used alone or a combination of an inorganic sunscreen agent and an organic sunscreen agent may be used. The inorganic blocking agent is either titanium dioxide (TiO ₂ ) or zinc oxide (ZincOxide), or the organic blocking agent is avobenzone, oxybenzone, octocrylene, homosalate, octisalate, octinosate, or ethylhexylmer. Any one of the toxycinnamates is used.

The base polymer used for the first active ingredient layer 11 and the base polymer used for the second active ingredient layer 12 have different molecular weights even though they are the same raw material (SEBS, SEPS or SEEPS), so by using raw materials of different grades, It is desirable not to mix the active ingredients of the two layers. When the base polymer contained in the first active ingredient layer 11 uses a raw material of a relatively low molecular weight grade and the second active ingredient layer 12 uses a raw material of a relatively high molecular weight grade, the second effective ingredient layer 12 Since the cohesive force of the ingredient layer 12 is higher, the rate of molecular activity of the ingredients is lowered, so that the active ingredient of the second active ingredient layer 12 is prevented from being mixed with the first active ingredient layer 11 when forming the active ingredient layer. will give

A first release paper 13 is attached to the inside of the first active ingredient layer 11, and a second release paper 13' is attached to the outside of the second active ingredient layer 12, respectively. remove and attach

The above description is illustrative of the present invention, and the embodiments disclosed in the specification are not intended to limit the technical idea of the present invention, but are for explanation. Various modifications and variations will be possible without departing from the technical idea of Therefore, the protection scope of the present invention should be construed by the matters described in the claims, and technical matters within the scope equivalent thereto should be construed as being included in the scope of the present invention.

10 : transparent patch
11: first active ingredient layer
12: second active ingredient layer
13, 13': first and second release papers

Claims (5)

A first active ingredient layer containing an adhesive resin, oil, and a first active ingredient in a base polymer;
a second active ingredient layer positioned outside the first active ingredient layer and containing oil and a second active ingredient in a base polymer;
first and second release papers positioned inside the first active ingredient layer and outside the second active ingredient layer, and removed and attached when attached to the skin;
It is made by providing
The first active ingredient layer includes 7 to 20 parts by weight of a base polymer using any one of SEBS (Styrene Ethylene Butylene Styrene), SEPS (Styrene-ethylene-propylene-styrene) or SEEPS (Styrene Ethylene Ethylene Propylene Styrene); 20 to 40 parts by weight of adhesive resin; 40 to 77 parts by weight of oil; It is composed of 0.5 to 5 parts by weight of the first active ingredient,
The second active ingredient layer includes 10 to 25 parts by weight of a base polymer using any one of SEBS, SEPS or SEEPS; 70 to 85 parts by weight of oil; It is composed of 5 to 25 parts by weight of the second active ingredient,
When forming the active ingredient layer, the base polymer contained in the first active ingredient layer uses a raw material of a relatively low molecular weight grade and the second active ingredient layer uses a raw material of a relatively high molecular weight grade. To prevent the active ingredients of the second active ingredient layer from being mixed with the first active ingredient layer,
The second active ingredient is a sunscreen ingredient,
As a sunscreen ingredient, either titanium dioxide (TiO ₂ ) and zinc oxide, which are inorganic sunscreens, or avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinosate, which are organic sunscreens. A soft transparent patch having a two-layer structure using a thermoplastic elastomer gel composition, characterized in that any one of ethylhexylmethoxycinnamate is used.
According to claim 1,
The adhesive resin is a soft transparent patch of a two-layer structure using a thermoplastic elastomer gel composition, characterized in that using a hydrogenated hydrocarbon resin among C5 or C9-based hydrocarbon resins.
According to claim 1,
The oil is a soft transparent patch of a two-layer structure using a thermoplastic elastomer gel composition, characterized in that any one of hydrogenated polydecene, squalane, and liquid paraffin is used.
According to claim 1,
The first active ingredient is a whitening ingredient or an anti-wrinkle ingredient,
Alpha-bisabolol, oil-soluble licorice extract, and ascorbyl tetraisopalmitate are used as whitening ingredients.
A soft transparent patch having a two-layer structure using a thermoplastic elastomer gel composition, wherein any one of retinol and retinyl palmitate is used as the anti-wrinkle component.
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