KR102513541B1 - Flexible film dosimeter and manufacturing method of the same - Google Patents

Abstract

The present invention relates to a flexible dosimeter and a manufacturing method thereof. A flexible dosimeter having a curved surface according to an embodiment of the present invention includes a sensitive layer whose color changes according to radiation dose and a silicon layer laminated on both sides of the sensitive layer, wherein the silicon layer is an upper silicon layer in contact with the dose measurement target, and and a lower silicon layer.

Description

Flexible film dosimeter and its manufacturing method {FLEXIBLE FILM DOSIMETER AND MANUFACTURING METHOD OF THE SAME}

The present invention relates to a flexible film dosimeter and a method for manufacturing the same, and more particularly, to a flexible film dosimeter for use in an eyeplaque device and a method for manufacturing the same.

An eye plaque device is a device used for brachytherapy of the eye, and the eye plaque is made of a metal plate of a ruthenium isotope that emits radiation. Brachytherapy using an eyeplaque device is a method of removing tumors by attaching an eyeplaque to the eyeball and irradiating radiation. It has the advantages of a short treatment period, easy operation, and the ability to maintain vision because the eyeball does not need to be removed. there is.

On the other hand, the quality control of these eye plaque devices is partially explained in a report published by The American Association of Physicists in Meidicine (AAPM), but there is currently no clear quality control protocol. Accordingly, in case of brachytherapy using eye plaque equipment, the specification provided by the eye plaque manufacturer must be used as it is or the dose distribution must be measured and verified on its own before use.

However, since the eye plaque has a curved surface for application to the eye, there is a limit to measuring the dose distribution of the eye plaque using a flat film or a known ion chamber.

Accordingly, there is a demand for the development of a dosimeter for measuring a dose distribution for quality control of eye plaques.

The present invention is to solve the problems of the prior art, and an object of the present invention is to provide a flexible film dosimeter capable of measuring the dose distribution of eye plaques and a method for manufacturing the same.

Furthermore, an object of the present invention is to provide a flexible film dosimeter and a method for manufacturing the same that can be applied to a target having a curved surface and cannot be measured with a conventional dosimeter.

A flexible film dosimeter according to an embodiment of the present invention includes an upper layer of a flexible material, a lower layer of a flexible material disposed on one side of the upper layer, and a responsive layer interposed between the upper and lower layers, and the responsive layer has a color depending on the amount of radiation. It can be changed to detect the dose distribution.

According to one embodiment of the present invention, the sensitive layer may include PCDA (Pentacosa-10,12-diynoate) or LiPCDA (lithium pentacosa-10,12-diynoate).

According to one embodiment of the present invention, the upper layer and the lower layer may each be made of silicon.

A method for manufacturing a flexible film dosimeter according to an embodiment of the present invention includes injecting silicone into a concave portion of a female mold, forming an upper layer by curing the silicone after coupling a first male mold to the female mold, and forming an upper layer in the concave portion of the female mold. Disposing a sensitive layer on the upper layer disposed in the upper part, injecting silicon into the upper part of the sensitive layer disposed in the concave part of the female mold, combining the second male mold with the female mold on which the upper layer and the sensitive layer are disposed, and then curing. and forming a lower layer.

In the flexible film dosimeter manufacturing method according to an embodiment of the present invention, the responsive layer may be formed by curing a mixture of an aqueous gelatin solution, an aqueous PVA solution, an aqueous PCDA solution, an aqueous solution of lithium acetate, and an aqueous solution of tartrazine.

According to one embodiment of the present invention, the content of the aqueous gelatin solution is 30 to 40% by weight, the content of the aqueous solution of PVA is 30 to 40% by weight, the content of the aqueous solution of PCDA is 20 to 30% by weight, and the content of the aqueous solution of lithium acetate is 5 to 40% by weight 10% by weight, the content of the aqueous solution of tartrazine may be 1 to 5% by weight.

According to one embodiment of the present invention, by forming the dosimeter to have a curved surface, it is possible to accurately and quickly measure the dose distribution of the target.

In addition, according to one embodiment of the present invention, by manufacturing the dosimeter using a material harmless to the human body, it can be used for measuring the distribution of dose in vivo.

1 is a schematic diagram of an eye plaque.
2 is a diagram showing a dose distribution of eye plaques.
3 is a cross-sectional view of a flexible film dosimeter according to an embodiment of the present invention.
4 is a view showing a mold for manufacturing a flexible film dosimeter according to an embodiment of the present invention.
5 is a view sequentially showing a manufacturing process of a flexible film dosimeter according to an embodiment of the present invention.
6 is a flowchart illustrating a manufacturing process of a sensitive layer of a flexible film dosimeter according to an embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, a preferred embodiment of the present invention will be described in detail so that those skilled in the art can easily practice it.

In order to clearly describe the present invention, descriptions of parts not related to the present invention are omitted, and the same reference numerals are given to the same components throughout the specification. In addition, since the size, thickness, position, etc. of each component shown in the drawings are arbitrarily shown for convenience of explanation, the present invention is not necessarily limited to those shown. That is, specific shapes, structures, and characteristics described in the specification may be changed and implemented from one embodiment to another without departing from the spirit and scope of the present invention, and the position or arrangement of individual components may also be implemented without departing from the spirit and scope of the present invention. and can be changed without departing from its scope.

Therefore, the detailed description to be described later is not performed in a limiting sense, and the scope of the present invention should be taken as encompassing the scope claimed by the claims and all scopes equivalent thereto.

1 is a schematic diagram of an eye plaque. The eye plaque is made of a ruthenium isotope metal plate and is configured to be attached to the eye so as to perform brachytherapy to the eye. As described above, in order to accurately and safely perform brachytherapy using eye plaques, it is necessary to check the dose distribution of eye plaques and to manage quality.

FIG. 2 is a diagram showing an eye plaque dose distribution. In general, an eye plaque manufacturer provides a dose distribution as shown together with eye plaque specifications. Users can refer to the manufacturer's specifications and dose distribution when using the eye plaque, but it is necessary to measure the dose distribution of the eye plaque for accurate and safe use and quality control.

For this purpose, a flexible film dosimeter and a manufacturing method thereof according to an embodiment of the present invention will be described.

flexible film dosimeter

3 is a cross-sectional view of a flexible film dosimeter according to an embodiment of the present invention. Referring to FIG. 3, the flexible film dosimeter 100 according to an embodiment of the present invention includes an upper layer 110, a lower layer 120, and an active layer interposed between the upper layer 110 and the lower layer 120. (130).

The upper layer 110 and the lower layer 120 according to an embodiment of the present invention are formed in a shape having a curved surface so that they can be used for eye plaques, and are made of a light and flexible material so that they can be used for eye plaques of various curvatures. In addition, the upper layer 110 and the lower layer 120 are made of a material with excellent biocompatibility so that they can be used in-vivo to measure radiation exposure of a patient. For example, the upper layer 110 and the lower layer 120 may be made of silicon.

When using the flexible film dosimeter 100, the upper layer 110 comes into contact with the dosimetry target. For example, the top layer 110 is in contact with the inner surface of the eye plaque. As shown, the upper layer 110 forms a convexly gently curved surface and may be formed to a thickness of about 1 mm. Depending on the thickness of the upper layer 110, the dose distribution measurement distance, that is, the distance between the sensitive layer 130 and the dose measurement target, which will be described later, is determined. Of course, it can be modified in various ways.

The lower layer 120 may be formed with a thin thickness considering that reading is performed with a scanner through the lower layer 120 when the flexible film dosimeter 100 is used. In this embodiment, the thickness of the lower layer 120 is about 0.20 to 0.35 mm, but it will be apparent to those skilled in the art that this can be changed.

The sensitive layer 130 according to an embodiment of the present invention performs a function of detecting a radiation dose. The sensitive layer 130 is interposed between the upper layer 110 and the lower layer 120 as described above. Accordingly, when the flexible film dosimeter 100 is used, the sensitive layer 130 detects the radiation dose of the measurement target, for example, an eye plaque, with the upper layer 110 interposed therebetween, and the scanner passes through the lower layer 120. , and the dose distribution is read from the sensitive layer 130 .

According to the present embodiment, the responsive layer 130 is polyvinyl alcohol (PVA), gelatin, 10, 12-pentacosadiynoic acid (PCDA), tetraethylammonium hydroxide It is produced in the form of a film using (Tetraethylammonium hydroxide), lithium acetate, and tartrazine as materials.

The sensitive layer 130 has an annular shape that matches the shapes of the upper layer 110 and the lower layer 120, and is widely spread over the entire surface of the upper layer 110 so that radiation dose can be detected throughout the dosimetric target, for example, an eye plaque. can be formed The responsive layer 130 is located between the upper layer 110 and the lower layer 120 and is formed in an annular shape, but is not limited thereto, and the shape and size of the responsive layer 130 may be formed differently depending on the target and purpose of measuring the dose. there is. In this embodiment, the thickness of the sensitive layer 130 is set to about 0.15 mm, but this may also be appropriately changed.

As such, the flexible film dosimeter 100 according to an embodiment of the present invention has a sandwich structure in which the sensitive layer 130 is located between the upper layer 110 and the lower layer 120, and the PCDA (Pentacosa- 10,12-diynoate) or LiPCDA (Lithium Pentacosa-10,12-diynoate) can detect radiation.

It has a curvature corresponding to the shape of a dosimetry target having a curved surface, such as an eye plaque, and is formed in a size capable of covering it as a whole. In addition, since the upper layer 110 and the lower layer 120 are formed of a flexible material, it can be applied to eye plaques of various shapes and sizes.

Furthermore, since the upper layer 110 and the lower layer 120 of the flexible film dosimeter 100 are made of a biocompatible material such as silicon, in vivo use is possible in a manner worn on the eyeball to measure radiation exposure.

Manufacturing method of flexible film dosimeter

4 is a view showing a mold for manufacturing a flexible film dosimeter according to an embodiment of the present invention, and FIG. 5 is a view sequentially showing a manufacturing process of a flexible film dosimeter according to an embodiment of the present invention. Hereinafter, the manufacturing method of the flexible film dosimeter according to the present invention will be described in detail with reference to these drawings.

The flexible film dosimeter 100 according to an embodiment of the present invention is manufactured through mold molding. Referring to FIG. 4, in order to manufacture the flexible film dosimeter 100 according to an embodiment of the present invention, first, a female mold 210 having a concave portion and a number having a convex portion paired with the concave portion of the female mold 210 A mold 220 is prepared. As the male mold 220 , two male molds 221 and 222 corresponding to the respective shapes of the upper layer 110 and the lower layer 120 are prepared. The first male mold 221 and the second male mold 222 have convex portions having different curvatures to form the upper layer 110 and the lower layer 120 , respectively. In this embodiment, the radius of curvature of the first male mold 221 is about 11.0 mm, and the radius of curvature of the second male mold 222 is about 10.5 mm.

In this embodiment, the flexible film dosimeter is manufactured with a female mold and a male mold having one concave portion and a convex portion, respectively, but by manufacturing a flexible film dosimeter with a female mold and a male mold having a plurality of concave portions and a plurality of convex portions, respectively. , it is also possible to manufacture a plurality of dosimeters at one time.

Referring to FIG. 5 , each layer is sequentially formed using a prepared mold. First, silicone is injected into the concave portion of the female mold 210, and the first male mold 221 is inserted into and compressed into the female mold 210 (see FIG. 5(a)).

Next, the female mold 210 and the first male mold 221 are placed in a pressure chamber in a coupled state and cured for about 48 hours to remove air bubbles (see (b) of FIG. 5). After curing, when the first male mold 221 is separated, a cured silicone layer is formed in the concave portion of the female mold 220, which becomes the upper layer 110 of the flexible film dosimeter 100 described above. As described above, the upper layer 110 may have a thickness of about 1 mm, which may be adjusted through the sizes and curvature radii of the female mold 210 and the first male mold 221 .

In the state where the upper layer 110 is formed on the arm mold 210, the pre-manufactured film-type sensitive layer 130 is cut and disposed (see FIG. 5(c)). The responsive layer 130 is preferably positioned at the center of the upper layer 110, and a separate adhesive may be injected to bond the upper layer 110 and the responsive layer 130 together.

Next, silicon is injected into the upper part of the sensitive layer 130, and the second male mold 222 is inserted into the female mold 210 and compressed (see (d) of FIG. 5).

Finally, as in the case of forming the upper layer 110, the lower layer 120 is formed when the female mold 210 and the second male mold 222 are cured in a pressure chamber for about 48 hours in a state of being combined (FIG. 5). (e)). As described above, the thickness of the lower layer 120 may be formed to be about 0.20 to 0.35 mm, and the thickness of the lower layer 120 can be determined through the sizes and curvature radii of the female mold 210 and the second male mold 222. can be adjusted

Figure 6 is a flow chart showing a manufacturing process of the sensitive layer of the flexible film dosimeter according to an embodiment of the present invention, with reference to this will be described in detail the manufacturing method of the sensitive layer according to this embodiment.

First, an aqueous gelatin solution (first solution), a PVA aqueous solution (second solution), a PCDA aqueous solution (third solution), a lithium acetate aqueous solution (fourth solution), and a tartrazine aqueous solution (fifth solution) are prepared respectively (S110) . The third solution is prepared by stirring 5% by weight of PCDA, 10% by weight of tetraethylammonium hydroxide aqueous solution and 85% by weight of water at about 70 to 80 ° C. At this time, the aqueous tetraethylammonium hydroxide solution is used as having a concentration of about 20% do.

Then, after mixing the first solution and the second solution, mixing the third solution and the fourth solution, mixing them again and stirring at about 60 to 70 ° C., the prepared mixed solution is kept at a low temperature of about 0 to 10 ° C. for several days. Aging (S120). Thereafter, the mixed solution is stirred again at about 60 to 70° C., and then pulverized using a sonicator for about 1 to 2 hours.

Next, after adding the fifth solution to the mixed solution that has undergone the above process, stirring is performed at about 60 to 70 ° C. for about 1 to 2 hours, and then cooled to 55 ° C. or less (S130). Thereafter, the mixed solution is spread thinly on the PET film using a coater and a bar coater, cured for about 40 to 50 hours, and then separated from the PET film (S140).

In this embodiment, the contents of the solutions used in the mixed solution are 30 to 40% by weight of the first solution, 30 to 40% by weight of the second solution, 20 to 30% by weight of the third solution, 5 to 10% by weight of the fourth solution, 5 solution 1 to 5% by weight.

Through the above process, a film used for the sensitive layer is manufactured, and it is cut into an appropriate size to be used in the manufacture of a flexible film dosimeter.

Although the present invention has been described above with specific details such as specific components and limited examples, the above examples are only provided to help a more general understanding of the present invention, and the present invention is not limited thereto, and the present invention is not limited thereto. Those skilled in the art can make various modifications and variations from these descriptions.

Therefore, the spirit of the present invention should not be limited to the above-described embodiments and should not be defined, and it can be said that not only the claims described below but also all modifications equivalent or equivalent to these claims belong to the scope of the spirit of the present invention. will be.

100: flexible film dosimeter
110: upper layer
120: lower layer
130: sensitive layer
210: arm mold
220: water mold
221: first water mold
222: second water mold

Claims (6)

As a flexible film dosimeter for use in eye plaque,
An upper layer made of a flexible material and configured to contact the inner surface of the eye plaque;
A lower layer of a flexible material disposed on one side of the upper layer and
A sensitive layer interposed between the upper layer and the lower layer
including,
The color of the sensitive layer changes according to the radiation dose to detect the dose distribution.
The upper layer and the lower layer are each made of silicon, form a convexly gently curved surface, and the radius of curvature of the upper layer is larger than that of the lower layer,
The upper layer is formed thicker than the lower layer, and the thickness of the lower layer is formed to 0.20 to 0.35 mm,
Flexible film dosimeter. According to claim 1,
The responsive layer includes PCDA (Pentacosa-10,12-diynoate) or LiPCDA (Lithium Pentacosa-10,12-diynoate),
Flexible film dosimeter. delete As a method for manufacturing a flexible film dosimeter for use in eye plaque,
Injecting silicon into the concave part of the arm mold;
Forming an upper layer by combining a first male mold with the female mold and then curing silicon;
disposing a sensitive layer on the upper layer disposed in the concave portion of the arm mold;
injecting silicon into an upper portion of the sensitive layer disposed in a concave portion of the female mold; and
Forming a lower layer by combining a second male mold with the female mold on which the upper layer and the responsive layer are disposed and then curing the mold;
including,
The first male mold and the second male mold have convex portions having different curvatures, and the radius of curvature of the first male mold is greater than the radius of curvature of the second male mold;
The upper layer and the lower layer form a convexly gently curved surface, and the radius of curvature of the upper layer is greater than that of the lower layer,
The upper layer is formed thicker than the lower layer, and the thickness of the lower layer is formed to 0.20 to 0.35 mm,
Manufacturing method of flexible film dosimeter. According to claim 4,
The responsive layer is formed by curing a mixture of an aqueous gelatin solution, an aqueous PVA solution, an aqueous PCDA solution, an aqueous solution of lithium acetate, and an aqueous solution of tartrazine, a flexible film dosimeter manufacturing method. According to claim 5,
The content of the aqueous gelatin solution is 30 to 40% by weight, the content of the aqueous solution of PVA is 30 to 40% by weight, the content of the aqueous solution of PCDA is 20 to 30% by weight, the content of the aqueous solution of lithium acetate is 5 to 10% by weight, The content of the tartrazine aqueous solution is 1 to 5% by weight, flexible film dosimeter manufacturing method.

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