KR102494208B1 - 소용돌이 단부 플러그를 갖는 흡입기 - Google Patents

소용돌이 단부 플러그를 갖는 흡입기 Download PDF

Info

Publication number
KR102494208B1
KR102494208B1 KR1020197012512A KR20197012512A KR102494208B1 KR 102494208 B1 KR102494208 B1 KR 102494208B1 KR 1020197012512 A KR1020197012512 A KR 1020197012512A KR 20197012512 A KR20197012512 A KR 20197012512A KR 102494208 B1 KR102494208 B1 KR 102494208B1
Authority
KR
South Korea
Prior art keywords
end cap
capsule
nicotine
inhaler
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020197012512A
Other languages
English (en)
Korean (ko)
Other versions
KR20190089857A (ko
Inventor
크리스토퍼 존 그랜트
제라드 주버
다니엘레 산나
지안루카 세치
쥬디스 월러
니키 멜론첼리
Original Assignee
필립모리스 프로덕츠 에스.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 필립모리스 프로덕츠 에스.에이. filed Critical 필립모리스 프로덕츠 에스.에이.
Publication of KR20190089857A publication Critical patent/KR20190089857A/ko
Application granted granted Critical
Publication of KR102494208B1 publication Critical patent/KR102494208B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter tips or filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces of cigars or cigarettes
    • A24D3/17—Filters specially adapted for simulated smoking devices
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/20—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/60—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Otolaryngology (AREA)
KR1020197012512A 2016-11-30 2017-11-17 소용돌이 단부 플러그를 갖는 흡입기 Active KR102494208B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16201579.6 2016-11-30
EP16201579 2016-11-30
PCT/IB2017/057219 WO2018100461A1 (en) 2016-11-30 2017-11-17 Inhaler with swirl end plug

Publications (2)

Publication Number Publication Date
KR20190089857A KR20190089857A (ko) 2019-07-31
KR102494208B1 true KR102494208B1 (ko) 2023-02-02

Family

ID=57460379

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197012512A Active KR102494208B1 (ko) 2016-11-30 2017-11-17 소용돌이 단부 플러그를 갖는 흡입기

Country Status (14)

Country Link
US (1) US11471622B2 (https=)
EP (1) EP3548125B1 (https=)
JP (1) JP7061124B2 (https=)
KR (1) KR102494208B1 (https=)
CN (1) CN109922852B (https=)
AR (1) AR110275A1 (https=)
AU (1) AU2017369977A1 (https=)
BR (1) BR112019008522A2 (https=)
CA (1) CA3038252A1 (https=)
IL (1) IL266805A (https=)
MX (1) MX2019005889A (https=)
PH (1) PH12019500633A1 (https=)
RU (1) RU2753681C2 (https=)
WO (1) WO2018100461A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3589146B1 (en) 2017-02-28 2023-04-05 Philip Morris Products S.A. Aerosol-generating device comprising a powder de-agglomerating actuator
MY200258A (en) * 2017-06-28 2023-12-17 Philip Morris Products Sa Container with particles for use with inhaler
US12496413B2 (en) 2018-02-19 2025-12-16 Philip Morris Products S.A. Dry powder inhaler
KR102694664B1 (ko) 2018-03-26 2024-08-14 필립모리스 프로덕츠 에스.에이. 와류 캡슐 공동을 갖는 흡입기
US11583640B2 (en) * 2018-04-20 2023-02-21 Gough Industries, Inc. Medicine vaporizer apparatus and methods of using the same
GB201812503D0 (en) 2018-07-31 2018-09-12 Nicoventures Holdings Ltd Aerosol generation
EP3911389B1 (en) * 2019-01-14 2023-03-01 Philip Morris Products, S.A. Dry powder inhaler device
GB201903243D0 (en) * 2019-03-11 2019-04-24 Nicoventures Trading Ltd Aerosol provision device
JP7641272B2 (ja) * 2019-09-26 2025-03-06 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ねじれた遠位端要素を備えた吸入器物品
CN114616010B (zh) * 2019-10-25 2024-06-14 菲利普莫里斯生产公司 具有开放远端的吸入器制品以及吸入器系统
CN114568018B (zh) * 2019-10-25 2025-01-10 菲利普莫里斯生产公司 具有切向气流端元件的吸入器制品
PL4048353T3 (pl) * 2019-10-25 2024-10-21 Philip Morris Products S.A. Wyrób inhalatorowy ze składanym końcem dystalnym
BR112022005554A2 (pt) * 2019-10-25 2022-06-21 Philip Morris Products Sa Suporte para artigo inalador
EP3935972B1 (de) * 2020-07-07 2023-09-06 Aptar Radolfzell GmbH Oralspender für flüssigkeiten, insbesondere für nikotin- oder cannabishaltige flüssigkeiten
EP4185354B1 (en) 2020-07-24 2024-05-01 Philip Morris Products S.A. Inhaler article
CN116829008A (zh) * 2020-12-18 2023-09-29 菲利普莫里斯生产公司 具有中空管状元件的吸入器制品
KR102824242B1 (ko) * 2022-11-02 2025-06-25 주식회사 케이티앤지 흡입기
WO2025114395A1 (en) * 2023-11-27 2025-06-05 Philip Morris Products S.A. Aerosol-generating article comprising tubular element having integral first and second tubular portions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522663A (ja) 2003-04-09 2006-10-05 ネクター セラピューティクス 空気入口シールドを備えたエアゾール化装置

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
DE3345722A1 (de) 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
IT1228459B (it) * 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US5167242A (en) 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
US5797391A (en) * 1991-03-28 1998-08-25 Rhone-Poulenc Rorer Limited Inhaler
US5441060A (en) * 1993-02-08 1995-08-15 Duke University Dry powder delivery system
SE9302550D0 (sv) * 1993-07-30 1993-07-30 Ernst Hoerlin Powder inhaler
US5727546A (en) * 1993-08-18 1998-03-17 Fisons Plc Powder inhaler with breath flow regulation valve
AR028746A1 (es) 2000-06-23 2003-05-21 Norton Health Care Ltd Cartucho de dosis previamente medidas para inhalador de polvo seco accionado por la respiracion, el inhalador y un metodo de provision de dosis previamente medidas de polvo seco
US20030094173A1 (en) * 2001-11-14 2003-05-22 Inhale Therapeutic Systems, Inc. Aerosolization device with improved endpiece connection
ITMI20020078A1 (it) 2002-01-16 2003-07-16 Fabrizio Niccolai Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
ES2310722T3 (es) 2003-03-20 2009-01-16 Galephar M/F Sistema inhalador de polvo seco mejorado.
GB0410712D0 (en) * 2004-05-13 2004-06-16 Novartis Ag Organic compounds
US7832399B2 (en) * 2006-03-10 2010-11-16 One Dose, Llc Medication inhaler
US8042550B2 (en) 2006-11-02 2011-10-25 Vladimir Nikolaevich Urtsev Smoke-simulating pipe
UA97004C2 (ru) 2007-08-10 2011-12-26 Филип Моррис Продактс С.А. Дистилляционное курительное изделие
CN101980738A (zh) * 2008-02-07 2011-02-23 华盛顿大学 圆周气雾设备
GB0901520D0 (en) * 2009-01-30 2009-03-11 Vectura Delivery Devices Ltd Inhaler
KR101257597B1 (ko) * 2009-02-23 2013-04-26 니뽄 다바코 산교 가부시키가이샤 비가열형 담배 향미 흡인기
DE102009037840B4 (de) * 2009-08-18 2012-08-16 Gamptec Gmbh Inhalationsvorrichtung und Verfahren zur Inhalation eines Wirkstoffs aus einer Kapsel
US20120000480A1 (en) * 2010-06-30 2012-01-05 Sebastian Andries D Biodegradable cigarette filter
WO2012163704A2 (de) * 2011-05-27 2012-12-06 Boehringer Ingelheim International Gmbh Inhalator und kapsel für einen inhalator
WO2013016784A1 (en) * 2011-08-04 2013-02-07 Victor Esteve Dry powder inhaler
EP2858701A2 (en) * 2012-06-06 2015-04-15 AeroDesigns, Inc Aerosol dispenser with replaceable cartridge
WO2014004400A2 (en) 2012-06-28 2014-01-03 The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services Nasal dry powder delivery system for vaccines and other treatment agents
RU125433U1 (ru) 2012-09-17 2013-03-10 Общество с ограниченной ответственностью "САМАРИН" Портативный электронный ингалятор
WO2015006838A1 (en) * 2013-07-16 2015-01-22 Victor Esteve Powder inhaler
US20150027468A1 (en) 2013-07-25 2015-01-29 Altria Client Services Inc. Electronic smoking article
RU143972U1 (ru) 2013-12-03 2014-08-10 Открытое Акционерное Общество "Фармацевтическая Фабрика Санкт-Петербурга" Ингалятор
AU2015254999B2 (en) * 2014-04-28 2019-08-01 Philip Morris Products S.A. Flavoured nicotine powder inhaler
RU2673611C2 (ru) 2014-06-20 2018-11-28 Филип Моррис Продактс С.А. Система доставки никотинового порошка со средствами управления потоком воздуха
PL3069620T5 (pl) 2015-03-19 2021-06-28 Fontem Holdings 1 B.V. Elektroniczne urządzenie do palenia
CN107614038B (zh) 2015-04-15 2021-04-20 菲利普莫里斯生产公司 具有部分剂量输送的干粉吸入器

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522663A (ja) 2003-04-09 2006-10-05 ネクター セラピューティクス 空気入口シールドを備えたエアゾール化装置

Also Published As

Publication number Publication date
US11471622B2 (en) 2022-10-18
EP3548125B1 (en) 2021-07-14
BR112019008522A2 (pt) 2019-07-09
JP7061124B2 (ja) 2022-04-27
MX2019005889A (es) 2019-08-14
CN109922852B (zh) 2023-11-07
PH12019500633A1 (en) 2019-11-11
AU2017369977A1 (en) 2019-04-11
WO2018100461A1 (en) 2018-06-07
RU2019116593A (ru) 2021-01-11
RU2753681C2 (ru) 2021-08-19
JP2019536454A (ja) 2019-12-19
CA3038252A1 (en) 2018-06-07
IL266805A (en) 2019-07-31
US20190307976A1 (en) 2019-10-10
RU2019116593A3 (https=) 2021-02-25
KR20190089857A (ko) 2019-07-31
CN109922852A (zh) 2019-06-21
AR110275A1 (es) 2019-03-13
EP3548125A1 (en) 2019-10-09

Similar Documents

Publication Publication Date Title
KR102494208B1 (ko) 소용돌이 단부 플러그를 갖는 흡입기
KR102545359B1 (ko) 맞춤 크기의 공동을 갖는 흡입기
KR102697599B1 (ko) 니코틴 입자 캡슐
JP7630990B2 (ja) 渦トンネルを備えた吸入器
US11964099B2 (en) Inhaler with vortex capsule cavity
KR102724157B1 (ko) 복합 다공성 지지 요소를 갖는 흡입기 물품 및 시스템
KR102840146B1 (ko) 천공형 다공성 지지 요소를 갖는 흡입기
KR102446498B1 (ko) 니코틴 입자 전달 소모품
JP2023022212A (ja) ニコチン粉末消耗品物品

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000