KR102486751B1 - A manufacturing method for Hydrogen Water with silica nano particles having embedded zinc and curcumin particles - Google Patents
A manufacturing method for Hydrogen Water with silica nano particles having embedded zinc and curcumin particles Download PDFInfo
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 118
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 58
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 54
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 239000001257 hydrogen Substances 0.000 title claims abstract description 33
- 229910052739 hydrogen Inorganic materials 0.000 title claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims description 107
- 235000012754 curcumin Nutrition 0.000 title claims description 54
- 239000004148 curcumin Substances 0.000 title claims description 54
- 229940109262 curcumin Drugs 0.000 title claims description 54
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims description 54
- 239000011701 zinc Substances 0.000 title claims description 29
- 229910052725 zinc Inorganic materials 0.000 title claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 22
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims description 20
- 239000002245 particle Substances 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 13
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910001882 dioxygen Inorganic materials 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 239000011148 porous material Substances 0.000 abstract description 4
- 238000005984 hydrogenation reaction Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 235000009697 arginine Nutrition 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
- 229930064664 L-arginine Natural products 0.000 description 2
- 235000014852 L-arginine Nutrition 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- -1 curcumin hydride Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011949 solid catalyst Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910007157 Si(OH)3 Inorganic materials 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000004517 catalytic hydrocracking Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002101 nanobubble Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910021336 sodium silicide Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
- B01F23/2376—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media characterised by the gas being introduced
- B01F23/23761—Aerating, i.e. introducing oxygen containing gas in liquids
- B01F23/237612—Oxygen
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
- B01F23/2376—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media characterised by the gas being introduced
- B01F23/23764—Hydrogen
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
- C02F1/685—Devices for dosing the additives
- C02F1/687—Devices for dosing solid compounds
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- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/36—Hydrogen production from non-carbon containing sources, e.g. by water electrolysis
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Abstract
Description
본 발명은 커큐민 입자 및 아연이 담지된 실리카 나노 입자를 활용하여 수소수를 제조하는 방법에 관한 것으로, 더욱 상세하게는 다공성 구조의 실리카 기공 내부 및 외면에 커큐민과 아연 입자가 담지된 실리카 나노 입자에 커큐민을 삽입하여 물에 투입한 후 수소를 주입하여 수소수를 만드는 제조 방법에 관한 것이다.The present invention relates to a method for producing hydrogen water by utilizing curcumin particles and zinc-supported silica nanoparticles, and more particularly, to silica nanoparticles supported with curcumin and zinc particles on the inside and outside of porous silica pores. It relates to a manufacturing method for producing hydrogen water by inserting curcumin into water and then injecting hydrogen.
근래 나노 기술(NT)은 생명공학(BT), 정보통신(IT) 등의 기술과 결합한 나노융합기술이 급속하게 발전하고 있으며, 특히 바이오 기술에 접목되어 건강기능식품, 질병의 조기진단, 질병 치료 약물의 선택적 전달, 혈액·유전자의 분리와 정제·분석 등과 같이 다양한 분야의 기술 개발 등에 활용되고 있다. 특히 수소는 수소차 등에서의 원료로 사용되고 있으며 그 사용이 확대되고 있다. 또한 상기 수소발생, 저장에 대해 커큐민을 활용한 수소화물이 사용되고 있으며, 일례로서 등록특허공보 등록번호 10-2071455호에는 융점이 180℃ 이상인 커큐민을 고체 촉매 존재 하에 용매 중에서 수소화 반응시켜 커큐민의 수소화물을 연속으로 제조하는 방법에 있어서, 수소화 반응기로부터 배출된 수소 가스를 수소화 반응기에 투입하는 커큐민 원료의 일부로 포함시켜 순환시키는 단계를 포함하여 수소화 반응기 내에서 고체 촉매의 수소 흡착효율을 보상한 상태로 수소화 반응을 수행하되, 상기 수소화 반응기 압력은 1~10bar 범위 내로 제어되고, 상기 수소화 반응기 온도는 50 내지 60℃ 범위 내로 제어되는 것인 커큐민 수소화물의 제조방법이 공개되어 있다.Recently, nanotechnology (NT) is rapidly developing nano-fusion technology combined with technologies such as biotechnology (BT) and information communication (IT). It is used for technology development in various fields such as selective delivery of drugs, separation, purification and analysis of blood and genes. In particular, hydrogen is used as a raw material for hydrogen vehicles and the like, and its use is expanding. In addition, a hydride using curcumin is used for hydrogen generation and storage. As an example, in Registered Patent Publication No. 10-2071455, curcumin having a melting point of 180 ° C or higher is hydrogenated in a solvent in the presence of a solid catalyst to form a curcumin hydride. In the method for continuously producing, hydrogenation is performed in a state in which the hydrogen adsorption efficiency of the solid catalyst is compensated for in the hydrogenation reactor, including the step of circulating the hydrogen gas discharged from the hydrogenation reactor as part of the curcumin raw material introduced into the hydrogenation reactor. A method for producing curcumin hydride is disclosed in which the reaction is performed, the pressure of the hydrogenation reactor is controlled within the range of 1 to 10 bar, and the temperature of the hydrogenation reactor is controlled within the range of 50 to 60 ° C.
또한, 공개특허공보 10-2016-0022754호에는 수소분자 용존수의 제조 방법이 공개되어 있고, 공개특허공보 2012-0040957호에는 커큐민 유도체의 효과 및 제조 방법이 공개되어 있다.In addition, Patent Publication No. 10-2016-0022754 discloses a method for preparing hydrogen molecule-dissolved water, and Patent Publication No. 2012-0040957 discloses the effect and production method of curcumin derivatives.
한편, 실리카가 수소 발생 시스템에 이용되는 종래 특허기술로서 공개번호 10-2011-0133615호에는 규화나트륨 및 나트륨 실리카겔 재료를 사용하는 수소 발생 시스템 및 방법이 공개되어 있고, 등록번호 10-0837195호에는 실리카-알루미나를 포함하는 촉매 및 탄화수소 공급원료의 수소화 분해에서의 이의 사용이 공개되어 있다.On the other hand, as a conventional patent technology in which silica is used in a hydrogen generating system, Publication No. 10-2011-0133615 discloses a hydrogen generating system and method using sodium silicide and sodium silica gel materials, and Registration No. 10-0837195 discloses silica - Catalysts comprising alumina and their use in hydrocracking of hydrocarbon feedstocks are disclosed.
그러나 상기 종래 기술들은 제조 공정이 복잡하고, 사용이 불편하며 수소를 잡아주는 효능이 약하여 장시간 사용, 보관시 수소가 이탈되어 효과가 떨어지는 단점이 있었다.However, the above conventional techniques have disadvantages in that the manufacturing process is complicated, the use is inconvenient, and the hydrogen holding effect is weak, so hydrogen is released during long-term use and storage, and the effect is reduced.
본 발명은 다공성 구조의 실리카 기공 내부 및 외면에 커큐민 및 아연이 담지된 실리카 나노 입자를 활용한 수소수의 제조 공정을 단순화함으로써 제조 공정이 간단하고, 사용상의 편리성과 지속 사용이 가능한 경제성을 갖는 것을 특징으로 하는 제조 방법을 제공하는 것을 그 목적으로 한다.The present invention simplifies the manufacturing process of hydrogen water using silica nanoparticles loaded with curcumin and zinc on the inside and outside of porous silica pores, so that the manufacturing process is simple, convenient in use, and economically sustainable. It aims at providing the manufacturing method characterized.
본 발명은 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용한 수소수 제조 방법에 관한 것으로, 커큐민 파우더를 알코올 수용액에 투입하여 주형 용액을 제조하는 1단계;The present invention relates to a method for producing hydrogen water using porous silica nanoparticles loaded with curcumin and zinc, comprising the steps of preparing a mold solution by adding curcumin powder to an aqueous alcohol solution;
상기 1단계에서 제조된 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 계속적으로 투입, 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 2단계;a second step of continuously adding zinc complex compound-adhered porous silica nanoparticles to the template solution prepared in step 1 to prepare curcumin complex compound-adhered silica nanoparticles;
상기 커큐민 착화합물 고착 실리카 나노 입자를 건조하는 3단계;로 이루어지는 것을 특징으로 한다.It is characterized in that it consists of; three steps of drying the curcumin complex compound-adhered silica nanoparticles.
또한, 상기 2단계에서 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 계속적으로 투입하되, 감압방식으로 교반하면서 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 것을 특징으로 한다.In the second step, the zinc complex compound-fixed porous silica nanoparticles are continuously added to the template solution, and the curcumin complex compound-fixed silica nanoparticles are prepared while stirring in a reduced pressure method.
또한, 상기 3단계를 거친 커큐민-아연 착화합물 고착 실리카 나노 입자를 물에 함유시키고 나노 버블화 되어있는 수소 및 산소 가스를 주입하는 것을 특징으로 한다.In addition, it is characterized in that the curcumin-zinc complex adhering silica nanoparticles that have undergone the above three steps are contained in water and nano-bubbled hydrogen and oxygen gas are injected.
본 발명에 따른 커큐민과 아연입자가 담지된 실리카 나노 입자는 다공성 구조의 실리카 나노 입자의 기공 내부 및 외면에 분산 삽입하여 그 제조 공정을 단순화함으로써 제조 공정이 간단하고, 사용상의 편리성과 지속 사용이 가능한 경제성을 동시에 이룰 수 있는 효과가 있으며, 실리카 나노 입자 속의 커큐민이 가지고 있는 수소를 잡아주는 효능을 최대한 발휘할 뿐만 아니라 기존에 적용되어 왔던 감압방식의 수소수와는 다르게 그 효능을 지속적으로 발현하게 함으로써 바이오 관련 적용 시장을 넘어서 의료 분야에서도 널리 적용될 수 있는 현저한 효과가 있다.The silica nanoparticles carrying curcumin and zinc particles according to the present invention are dispersed and inserted into the pores of the porous silica nanoparticles to simplify the manufacturing process. It has the effect of achieving economic feasibility at the same time, and not only maximizes the effect of capturing hydrogen of curcumin in silica nanoparticles, but also continuously expresses its efficacy unlike conventionally applied hydrogen water of the reduced pressure method. There is a remarkable effect that can be widely applied in the medical field beyond the related application market.
도 1은 본 발명의 제조 공정도1 is a manufacturing process diagram of the present invention
본 발명은 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용한 수소수 제조 방법에 관한 것으로, 커큐민 파우더를 알코올 수용액에 투입하여 주형 용액을 제조하는 1단계;The present invention relates to a method for producing hydrogen water using porous silica nanoparticles loaded with curcumin and zinc, comprising the steps of preparing a mold solution by adding curcumin powder to an aqueous alcohol solution;
상기 1단계에서 제조된 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 계속적으로 투입, 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 2단계;a second step of continuously adding zinc complex compound-adhered porous silica nanoparticles to the template solution prepared in step 1 to prepare curcumin complex compound-adhered silica nanoparticles;
상기 커큐민 착화합물 고착 실리카 나노 입자를 35~45도에서 약 15분간 건조하는 3단계;로 이루어지는 것을 특징으로 한다.It is characterized in that it consists of; three steps of drying the curcumin complex compound-adhered silica nanoparticles at 35 to 45 degrees for about 15 minutes.
또한, 1단계에서 사용되는 수용액은 알코올 수용액인 것을 특징으로 한다.In addition, the aqueous solution used in the first step is characterized in that it is an alcohol aqueous solution.
또한, 상기 커큐민 파우더는 발효처리한 것을 사용하는 것을 특징으로 한다.In addition, the curcumin powder is characterized in that the fermented one is used.
또한, 상기 발효처리는 24시간 동안 발효기에서 발효하는 것을 특징으로 한다.In addition, the fermentation treatment is characterized by fermentation in a fermentor for 24 hours.
또한, 상기 2단계에서 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 투입하되, 감압방식으로 교반하면서 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 것을 특징으로 한다.In addition, in step 2, the zinc complex compound-adhered porous silica nanoparticles are added to the template solution, and the curcumin complex compound-adhered silica nanoparticles are prepared while stirring in a reduced pressure method.
또한, 상기 3단계에서 커큐민 착화합물 고착 실리카 나노 입자를 35~40℃에서 12 ~ 20분간 건조하는 것을 특징으로 한다.In addition, in the third step, the curcumin complex compound-adhered silica nanoparticles are dried at 35 to 40 ° C. for 12 to 20 minutes.
또한, 상기 커큐민-아연 착화합물 고착 실리카 나노 입자가 함유된 물에 나노 버블화 되어있는 수소 및 산소 가스를 주입하는 것을 특징으로 한다.In addition, it is characterized by injecting nano-bubbled hydrogen and oxygen gas into the water containing the curcumin-zinc complex adhering silica nanoparticles.
본 발명을 첨부 도면에 의해 상세히 설명하면 다음과 같다. 도 1은 본 발명의 제조 공정도이다.The present invention will be described in detail with reference to the accompanying drawings. 1 is a manufacturing process diagram of the present invention.
본 발명 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용한 수소수 제조 방법은 커큐민 파우더([HOC6H3(OCH3)CH=CHCO]2CH2)를 알코올 수용액에 투입하여 주형 용액을 제조하는 1단계;In the method for producing hydrogen water using porous silica nanoparticles loaded with curcumin and zinc of the present invention, a mold solution is prepared by adding curcumin powder ([HOC 6 H 3 (OCH 3 )CH=CHCO] 2 CH 2 ) to an aqueous alcohol solution. step 1;
상기 1단계에서 제조된 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자(Zn(NO3)6H2O)를 투입, 커큐민 착화합물 고착 실리카 나노 입자(Zn-(Si(OH)3)-[HOC6H3(OCH3)CH=CHCO]2CH2)를 제조하는 2단계;Zinc complex compound-adhered porous silica nanoparticles (Zn(NO3)6H2O) were added to the template solution prepared in step 1 above, and curcumin complex compound-adhered silica nanoparticles (Zn-(Si(OH)3)-[HOC 6 H 3 (OCH) 3 ) CH=CHCO] 2 CH 2 ) 2 steps to prepare;
상기 커큐민 착화합물 고착 실리카 나노 입자를 35~40℃에서 약 30분에서 1시간 건조하는 3단계;로 이루어진다.A third step of drying the curcumin complex compound-fixed silica nanoparticles at 35 to 40° C. for about 30 minutes to 1 hour.
1단계에서 사용되는 수용액은 알코올 수용액을 사용한다. 혼합비율은 중량비로 알코올 수용액 80 ~ 90 : 커큐민 착화합물 고착 실리카 나노 입자 10 ~ 20 비율이다.As the aqueous solution used in the first step, an aqueous alcohol solution is used. The mixing ratio is 80 to 90 in alcohol solution: 10 to 20 in weight ratio of silica nanoparticles with curcumin complex.
그리고 본 발명의 상기 커큐민 파우더는 발효처리한 것을 사용할 수 있는 것으로, 발효처리는 유익균, 유용미생물, 프로바이오틱스로 발효하되, 발효기에서 24시간 이상 발효하여 제품의 품질이 향상되게 한다.In addition, the curcumin powder of the present invention can be fermented, and the fermentation process is fermented with beneficial bacteria, useful microorganisms, and probiotics, and fermented in a fermenter for 24 hours or more to improve the quality of the product.
그리고 본 발명은 상기 2단계에서 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 투입하되, 특히 감압방식으로 압력을 낮추어 가며 교반하면서 커큐민 착화합물 고착 실리카 나노 입자를 제조한다. 이는 외부압력을 높여서 감압형식으로 실리카 내의 포러스 구조안에 커큐민을 포접시키는 효과를 향상시키는 것이다. 진공압력은 35bar~45bar이다. 혼합비율은 중량비로 주형용액 92 ~ 97 : 커큐민 착화합물 고착 실리카 나노 입자 3 ~8이다.Further, in the second step of the present invention, the zinc complex compound-adhered porous silica nanoparticles are added to the template solution, and in particular, the curcumin complex compound-adhered silica nanoparticles are prepared while stirring while lowering the pressure in a reduced pressure method. This is to increase the external pressure to improve the effect of encapsulating curcumin in the porous structure in the silica in the form of reduced pressure. The vacuum pressure is 35 bar to 45 bar. The mixing ratio is 92 to 97 of the template solution: 3 to 8 of the curcumin complex compound-fixed silica nanoparticles in weight ratio.
상기 3단계는 커큐민 착화합물 고착 실리카 나노 입자를 35~40℃에서 30분에서 ~ 1시간 건조하는 공정이다. 최적온도와 건조시간은 39℃에서, 35분간이 적정하다. 건조공정에서 외부온도가 40℃가 넘어가면 커큐민의 변색이 일어날 수 있고 너무 낮으면 건조되지 않는다. 건조시간은 30분에서 1시간 정도가 적당하다. 30분 미만이면 건조가 불충분하고 1시간을 초과하면 품질이 나빠진다.The third step is a process of drying the curcumin complex compound-adhered silica nanoparticles at 35 to 40° C. for 30 minutes to 1 hour. The optimum temperature and drying time are 35 minutes at 39℃. If the outside temperature exceeds 40℃ in the drying process, discoloration of curcumin may occur, and if it is too low, it will not dry. Drying time is about 30 minutes to 1 hour. Drying is insufficient if less than 30 minutes, and quality deteriorates if it exceeds 1 hour.
한편, 본 발명은 제조된 상기 커큐민-아연 착화합물 고착 실리카 나노 입자를 다음 4단계로서, 물 10L에 대하여 10~500mg을 투입하여 교반한다. 그리고 상기 커큐민-아연 착화합물 고착 실리카 나노 입자가 함유된 물에 나노 버블화 되어있는 수소 또는 산소 가스를 5단계로 주입한다. 그러므로 반응성이 큰 아연에 아르기닌과 커큐민이 잘 흡착될 수 있고, 아르기닌과 커큐민에 들어 있는 전기음성도가 강한 N(질소), O(산소)가 수소를 갖는 분자가 이웃한 분자의 수소 원자 사이에서 생기는 정전기적 인력으로 수소를 잡아당기고 추가적으로 실리카 나노 입자의 다공성 구조에 의해서 수소를 가둬둘 수 있는 구조가 된다.On the other hand, in the present invention, 10 to 500 mg of the prepared curcumin-zinc complex adhering silica nanoparticles is added to 10 L of water and stirred as the following 4 steps. In addition, nano-bubbled hydrogen or oxygen gas is injected into the water containing the curcumin-zinc complex-adhered silica nanoparticles in five stages. Therefore, arginine and curcumin can be well adsorbed on highly reactive zinc, and molecules with strong electronegativity N (nitrogen) and O (oxygen) in arginine and curcumin have hydrogen atoms between adjacent molecules. The resulting electrostatic attraction attracts hydrogen and additionally becomes a structure capable of confining hydrogen by the porous structure of silica nanoparticles.
본 발명은 상기 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용하여 수소수를 제조하는 것으로, 수소수는 기존의 물을 일반적인 주지관용 방법인 전기분해 방식을 통하여 발생한 수소가스를 포집한 커큐민 그리고/또는 엘-아르기닌을 담지한 다공성 아연 실리카 입자가 분산되어 있는 마실 수 있는 물에, 나노버블 장치를 통하여 나노 버블화 되어있는 수소 또는 산소 가스를 주입하는 방식을 통하여 제조된다.The present invention is to produce hydrogen water by utilizing the curcumin and zinc-supported porous silica nanoparticles. Alternatively, it is prepared by injecting nanobubbled hydrogen or oxygen gas through a nanobubble device into drinkable water in which porous zinc silica particles carrying L-arginine are dispersed.
상기와 같은 4, 5단계에 의해 처리되어 커큐민-아연 착화합물 고착 실리카 나노 입자가 함유되고 수소 및 산소 가스가 주입된 물 혼합 용액은 커큐민이 가지고 있는 효능을 최대한 발휘할 뿐만 아니라 그 효능을 지속적으로 발현하게 하는 상승된 효과가 있다.The water mixture solution treated by the above steps 4 and 5, containing curcumin-zinc complex-fixed silica nanoparticles and infused with hydrogen and oxygen gas, not only maximizes the efficacy of curcumin, but also continuously expresses its efficacy. There is an increased effect of
한편, 본 발명은 L-아르기닌을 커큐민에 함께 또는 대체하여 첨가할 수 있는 것으로, 커큐민의 두배의 양을 첨가한다. 곧 커큐민으로 제조시에 10mg~500mg을 사용하였다면, 몰질량이 커큐민의 약 2분의1 작용효과에 해당하는 물질인 아르기닌은 그 양의 두배인 20mg에서 1000mg을 사용해주어야 커큐민과 동일한 효과를 볼 수 있다. On the other hand, in the present invention, L-arginine can be added together with or instead of curcumin, and the amount of twice the amount of curcumin is added. In other words, if 10mg~500mg of curcumin was used in manufacturing, arginine, a substance whose molar mass corresponds to about half of curcumin's action effect, needs to be used in 20mg to 1000mg, which is twice the amount, to see the same effect as curcumin. there is.
Claims (3)
상기 1단계에서 제조된 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 계속적으로 투입, 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 2단계;
상기 커큐민 착화합물 고착 실리카 나노 입자를 건조하는 3단계;로 이루어지는 것으로,
상기 2단계에서 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 투입하되, 감압방식으로 교반하면서 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 것이며,
상기 3단계를 거친 커큐민-아연 착화합물 고착 실리카 나노 입자를 물에 함유시키고 나노 버블화 되어있는 수소 또는 산소 가스를 주입하는 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용한 수소수 제조 방법에 있어서,
상기 1단계에서 사용되는 수용액은 알코올 수용액을 사용하는 것으로, 혼합비율은 중량비로 알코올 수용액 80 ~ 90 : 커큐민 착화합물 고착 실리카 나노 입자 10 ~ 20 비율이며,
상기 2단계에서 주형 용액에 아연 착화합물 고착 다공성 실리카 나노 입자를 투입하되, 감압방식으로 압력을 낮추어 교반하면서 커큐민 착화합물 고착 실리카 나노 입자를 제조하는 것으로, 진공압력은 35bar~45bar이고, 혼합비율은 중량비로 주형용액 92 ~ 97 : 커큐민 착화합물 고착 실리카 나노 입자 3 ~8이며,
상기 3단계는 커큐민 착화합물 고착 실리카 나노 입자를 35~40℃에서 30분에서 ~ 1시간 건조하는 공정이며,
제조된 상기 커큐민-아연 착화합물 고착 실리카 나노 입자를 다음 단계인 4단계에서, 물 10L에 대하여 10~500mg을 투입하여 교반하고 상기 커큐민-아연 착화합물 고착 실리카 나노 입자가 함유된 물에 나노 버블화 되어있는 수소 또는 산소 가스를 다음단계인 5단계에서 주입하는 것을 특징으로 하는 커큐민 및 아연이 담지된 다공성 실리카 나노 입자를 활용한 수소수 제조 방법Step 1 of preparing a mold solution by adding curcumin powder to an aqueous alcohol solution;
a second step of continuously adding zinc complex compound-adhered porous silica nanoparticles to the template solution prepared in step 1 to prepare curcumin complex compound-adhered silica nanoparticles;
Consisting of three steps of drying the curcumin complex compound-adhered silica nanoparticles,
In the second step, the zinc complex compound-fixed porous silica nanoparticles are added to the template solution, while stirring in a reduced pressure method to prepare the curcumin complex compound-fixed silica nanoparticles,
In the method for producing hydrogen water using porous silica nanoparticles loaded with curcumin and zinc, in which the curcumin-zinc complex adhering silica nanoparticles passed through the above three steps are contained in water and nano-bubbled hydrogen or oxygen gas is injected,
The aqueous solution used in the first step is an alcohol aqueous solution, and the mixing ratio is 80 to 90 alcohol aqueous solution: 10 to 20 curcumin complex compound-adhered silica nanoparticles in weight ratio,
In the second step, the zinc complex compound-fixed porous silica nanoparticles are added to the template solution, and the curcumin complex compound-fixed silica nanoparticles are prepared while stirring by lowering the pressure in a reduced pressure method. The vacuum pressure is 35 bar to 45 bar, and the mixing ratio is by weight Template solution 92 to 97: curcumin complex compound adhering silica nanoparticles 3 to 8,
The third step is a process of drying the curcumin complex compound-adhered silica nanoparticles at 35 to 40 ° C. for 30 minutes to 1 hour,
In the next step, step 4, the prepared curcumin-zinc complex compound-fixed silica nanoparticles are stirred by adding 10 to 500 mg to 10L of water, and the curcumin-zinc complex compound-fixed silica nanoparticles are nano-bubbled in the water containing the nanoparticles. Method for producing hydrogen water using porous silica nanoparticles loaded with curcumin and zinc, characterized by injecting hydrogen or oxygen gas in the next step, step 5
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| JP2001215221A (en) * | 2000-02-02 | 2001-08-10 | Air Liquide Japan Ltd | Reagent and method for detecting halide |
| JP2004330146A (en) * | 2003-05-09 | 2004-11-25 | Nippon Torimu:Kk | Production method of active hydrogen dissolved water, and active hydrogen dissolved water and carcinogenesis inhibitor obtained by the production method |
| JP2005177724A (en) * | 2003-12-16 | 2005-07-07 | Hiroshima Kasei Ltd | Apparatus for producing hydrogen-containing water |
| JP2006095389A (en) * | 2004-09-28 | 2006-04-13 | Kurita Water Ind Ltd | Hydrogen water manufacturing method and electronic component cleaning method |
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