KR102461196B1 - Lubricant composition with sperm activation effect - Google Patents

Abstract

A lubricating composition that has sperm activity and helps overcome infertility or infertility is provided. The lubricating composition can include purified water, PBS, fructose (C_6H_12O_6), and thickeners.

Description

Lubricating composition with sperm activation effect {LUBRICANT COMPOSITION WITH SPERM ACTIVATION EFFECT}

The present invention relates to a lubricating composition. Specifically, it relates to a lubricating composition that has sperm activity and helps to overcome infertility or infertility.

In general, infertility (subfertility) or infertility (sterility) is academically defined as men and women of childbearing age are unable to achieve pregnancy within one year despite having normal sex without contraception. It is reported that about 15% of couples of childbearing age experience infertility or infertility.

Conventionally, infertility has been used to refer to a state in which pregnancy is impossible, but recently, a case in which the cause of a pregnancy disorder is identified is referred to as infertility, and a case in which the cause of the pregnancy disorder is not identified is also referred to as infertility. In this specification, the terms infertility and infertility may be used interchangeably.

Infertility can be caused by a wide variety of causes, but when the cause is in a man, it is called male infertility, and when the cause is in a woman, it is called female infertility. Male infertility and female infertility each account for about 40% of all infertility, and infertility of unknown causes accounts for the remaining 20%.

Male infertility can be classified into other causes such as sperm abnormalities, sperm movement pathways, semen abnormalities, sexual intercourse abnormalities, and chronic diseases. Among these, abnormalities in sperm can be subdivided into abnormalities in the sperm itself with abnormalities in the number, shape, motility, capacity, pH, etc. of sperm, hypospermia in which sperm production is reduced, and hypospermia in which sperm activity is weak. On the other hand, the most common cause of female infertility is ovulation disorder, but other causes include uterine adhesions, fallopian tube obstruction, inflammation, and lack of mucus.

Even if the period stipulated by the academic definition of infertility or infertility has not elapsed, that is, about a year, if pregnancy does not occur for several months despite normal sexual intercourse, couples who want to become pregnant are stressed by self-doubt of infertility or infertility, This can lead to a vicious cycle that makes pregnancy more difficult.

In addition, even when one or more of a couple is medically diagnosed with infertility, the reality is that there is no proper solution depending on the type of infertility.

For example, in the case of the aforementioned male infertility, in particular, sperm abnormality, it does not show clear efficacy despite hormone injection or drug treatment, and currently there is no therapeutic agent for improving sperm motility. The reality is that it is difficult for men to overcome infertility caused by sperm abnormalities except to avoid stress, change lifestyles such as keeping body temperature low, or perform procedures such as in vitro fertilization.

Similarly, in the case of female infertility, there is a cause that can be overcome through surgical treatment, but there is no proper solution in the case of a lack of mucus.

Accordingly, the problem to be solved by the present invention is to provide a lubricating composition that can be used by a couple before or after being diagnosed with infertility. That is, it is to provide a lubricating composition that has a sperm activating effect and can help pregnancy.

Another problem to be solved by the present invention is to provide a composition that helps pregnancy.

The problems of the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly understood by those skilled in the art from the following description.

A lubricating composition according to an embodiment for solving the above problems includes purified water; PBS; fructose (fructose, C ₆ H ₁₂ O ₆ ); and thickeners.

The lubricating composition may be used for sexual intercourse to control pregnancy.

The fructose may be included in the range of 0.2 mg/mL to 5.0 mg/mL.

In some embodiments, 0.2 mg/mL to 0.5 mg/mL of folic acid; and 0.01 mg/mL to 0.1 mg/mL of heparin.

In some embodiments, 0.2 mg/mL to 0.5 mg/mL of thiamine; and riboflavin 0.2 mg/mL to 0.5 mg/mL.

In some embodiments, 0.01 mg/mL to 0.2 mg/mL of pyridoxal; and 0.1 mg/mL and 0.5 mg/mL of syntol AMD.

In some embodiments, 0.01 mg/mL to 0.2 mg/mL of lecithin; flavonol 0.01 mg/mL to 0.2 mg/mL; And Cucurbitin (cucurbitin) 0.01mg / mL to 0.05mg / mL may be further included.

A composition for treating infertility according to an embodiment of the present invention for solving the other problem is purified water; PBS; fructose (fructose, C ₆ H ₁₂ O ₆ ); and thickeners.

A lubricating composition according to an embodiment of the present invention for solving the another problem is purified water; PBS; fructose (fructose, C ₆ H ₁₂ O ₆ ); and thickeners.

Details of other embodiments are included in the detailed description.

According to embodiments of the present invention, it is possible to provide a lubricating composition that helps a couple who are planning to get pregnant. The lubricating composition of the present invention has sperm activity, so that it can increase the chances of getting pregnant despite at least abnormalities in sperm, that is, sperm count, shape, motility, capacity, and/or male infertility such as hypospermia, and/or sciatica. have.

In addition, since the present invention is provided in the form of a lubricating composition, even in the case of a couple before being diagnosed with infertility or infertility, or before self-recognizing infertility and infertility, using the lubricating composition of the present invention in sexual intercourse increases sexual sensation and pregnancy In particular, it can overcome infertility caused by lack of mucus in women.

Effects according to the embodiments of the present invention are not limited by the contents exemplified above, and more various effects are included in the present specification.

1 is an image showing results according to an experimental example.
2 is an image showing a change in the movement speed of sperm.
3 is an image showing the survival rate of sperm.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, and only the embodiments allow the disclosure of the present invention to be complete, and those of ordinary skill in the art to which the present invention pertains. It is provided to fully inform the person of the scope of the invention, and the present invention is only defined by the scope of the claims. That is, various changes may be made to the embodiments presented by the present invention. It should be understood that the embodiments described below are not intended to limit the embodiments, and include all modifications, equivalents, and substitutions thereto.

Unless otherwise defined, all terms (including technical and scientific terms) used herein may be used with the meaning commonly understood by those of ordinary skill in the art to which the present invention belongs. In addition, terms defined in a commonly used dictionary are not to be interpreted ideally or excessively unless clearly defined in particular.

In this specification, 'and/or' includes each and every combination of one or more of the mentioned items. The singular also includes the plural, unless the phrase specifically states otherwise. As used herein, 'comprises' and/or 'comprising' does not exclude the presence or addition of one or more other components in addition to the stated components. Numerical ranges indicated using 'to' indicate numerical ranges including the values set forth before and after them as lower and upper limits, respectively. 'About' or 'approximately' means a value or numerical range within 20% of the value or numerical range recited thereafter.

Hereinafter, the present invention will be described in detail.

The lubricating composition according to an embodiment of the present invention includes purified water, PBS, fructose and a thickener, and further contains one or more of folic acid, heparin, thiamine, riboflavin, pyridoxal, synthol AMD, lecithin, flavonol, and cucurbitin. may include

Purified water may be used as a solvent for dissolving the components of the lubricating composition. In addition, PBS can function as a pH buffer solution. In an exemplary embodiment, the pH of the lubricating composition according to this embodiment may be about 7.5 to 8.5, or about 7.8 to 8.2, or about 7.9 to 8.1.

Fructose can confer activity on sperm. Fructose is a hexose sugar, and is known to exist in an equilibrium state of fructopyranose, fructofuranose, and more. Fructose, a monosaccharide, can provide sperm activity without interfering with sperm activity, unlike polysaccharides or disaccharides such as cellulose. Cellulose is known to be somewhat beneficial for sperm activity, but may cause a decrease in fertility. In addition, unlike glucose, which can cause a decrease in the fertilization ability of the egg, fructose is non-toxic to the egg (or oocyte) and fertilized embryo and can provide sperm activity.

Fructose may be included in the range of 0.2 mg/mL to 5.0 mg/mL with respect to the total composition. When fructose is contained above the above range, for example, when it is contained at a concentration exceeding about 10.0 mg/mL, cytotoxicity may be induced. On the other hand, when fructose is contained less than the above range, the sperm activation effect may be insignificant.

The lubricating composition according to this embodiment may be an aqueous lubricant. For aqueous lubricants that are substantially free of oil-based components, the thickening agent includes guar gum, but may not include cellulose and/or carrageenan gum. Cellulose and/or carrageenan gum may cause decreased sperm motility.

Folic acid, along with fructose, can confer activity on sperm. Folic acid may be contained in a concentration of 0.2 mg/mL to 0.5 mg/mL. When the content of folic acid exceeds the above range, the lubricating composition may become cloudy. On the other hand, when the content of folic acid is less than the above range, the effect of increasing sperm activity may be insignificant.

Heparin can promote fertilization of sperm and eggs. Heparin may be contained in a concentration of 0.01 mg/mL to 0.1 mg/mL. When the content of heparin exceeds the above range, cytotoxicity may be induced. On the other hand, when the content of heparin is less than the above range, the fertilization promoting effect may be insignificant.

Thiamine pyrophosphate which is naturally derived from thiamine or thiamine and is present in solution can confer activity on sperm together with fructose. In addition, thiamine can maximize the activity of riboflavin. Thiamine may be contained in a concentration of 0.2 mg/mL to 0.5 mg/mL. When the content of thiamine exceeds the above range, a decrease in pH may be caused. On the other hand, when the content of thiamine is less than the above range, the effect of increasing sperm activity may be insignificant.

Riboflavin can promote fertilization of sperm and egg. In addition, riboflavin may exhibit some thickening effect. Riboflavin may be contained in a concentration of 0.2 mg/mL to 0.5 mg/mL. When the content of riboflavin exceeds the above range, the viscosity of the lubricant may increase excessively. On the other hand, when the content of riboflavin is less than the above range, the fertilization promoting effect may be insignificant.

Pyridoxal together with fructose can confer activity on sperm. Pyridoxal may be contained in a concentration of 0.01 mg/mL to 0.2 mg/mL. If the content of pyridoxal exceeds the above range, cytotoxicity may be caused. In addition, the shelf life of the lubricating composition may be reduced. On the other hand, when the content of pyridoxal is less than the above range, the effect of increasing sperm activity may be insignificant.

Synthol AMD is a type of lactic acid bacteria. Synthol AMD keeps the intrauterine environment slightly alkaline, and can be used as a pH adjuster in lubricating compositions. Synthol AMD can also promote sperm and egg fertilization. Synthol AMD may be contained in concentrations of 0.1 mg/mL and 0.5 mg/mL. When synthol AMD exceeds the above range, for example, when it is contained in a concentration exceeding 1.0 mg/mL, spermicidal properties may be expressed. On the other hand, when the content of synthol AMD is less than the above range, the fertilization promoting effect may be insignificant.

Lecithin together with fructose can confer activity on sperm. It can also protect sperm. Lecithin may be contained in a concentration of 0.01 mg/mL to 0.2 mg/mL. When the content of lecithin exceeds the above range, abnormal movement of sperm may be induced. On the other hand, if the content of lecithin is less than the above range, the sperm activation effect may be insignificant.

Flavonols, together with fructose, can confer activity on sperm. The flavonol may be contained in a concentration of 0.01 mg/mL to 0.2 mg/mL. If the content of flavonol exceeds the above range, the lubricating composition may become cloudy. On the other hand, when the content of flavonol is less than the above range, the effect of increasing sperm activity may be insignificant. Preferred examples of the flavonol compound include quercetin, but the present invention is not limited thereto.

Cucurbitin may enhance the effects of lecithin and flavonols. Cucurbitin may be contained in an amount of 0.01 mg/mL to 0.05 mg/mL. When the content of cucurbitin exceeds the above range, it may cause inhibition of fertilization. On the other hand, when the content of cucurbitin is less than the above range, the increase in the sperm activity effect of lecithin and flavonol may be insignificant.

Although the present invention is not limited thereto, the lubricating composition according to this embodiment comprises ethylenediaminetetraacetic acid (EDTA), vitamin C having acidity, an oily vitamin-based substance that provides contamination or denaturation on an aqueous base, and/or Alcohol-like substances such as glycerol having spermicidal properties may not be included.

In some embodiments, the lubricating composition according to the present embodiment may further include an antioxidant, a sperm activator fertilization promoter, and/or a radical agent in addition to the above. For example, the lubricating composition may further include potassium, sodium, calcium, magnesium, albumin, peptide, caffeine, pyruvate, niacinamide, glutathione, panthenol, progesterone and/or hyaluronan, and the like. However, these are merely illustrative of modifications of the present invention, and the present invention is not limited thereto.

The lubricating composition according to the present embodiment may be transparent and non-irritating and non-toxic to body tissues. In addition, the lubricating composition may be provided in the form of a solution, a gel, a foam, a cream, a soluble film, and the like. When the lubricating composition is provided in a fluid state, it may be implemented in the form of an ampoule, a package, a vial, a pump bottle, a tube bottle, a pouch, a coating agent, and/or a disposable product, but the present invention is not limited thereto. The lubricating composition according to the present embodiment can be used to cover and lubricate and/or moisturize body tissues, such as the penis or vaginal mucosa.

Hereinafter, production examples of the present invention will be described.

<Production Example>

As a buffer solution, 1X PBS was used. And a lubricating composition was prepared with the composition shown in Table 1 below. Guar gum for viscosity control was mixed in an appropriate amount. In each of the preparation examples, the weight of guar gum was about 0.7 wt%. All of the compositions prepared by adjusting the content of the composition were within the range of pH 7.5 to 8.5.

control comparative example Preparation Example 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 Distilled water and PBS whole quantity balance balance balance balance balance balance Guar Gum - appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount fruit sugar - - 2.5mg/mL 2.5mg/mL 2.5mg/mL 2.5mg/mL 2.5mg/mL cellulose - 2.5mg/mL - - - - - folic acid - - - - 0.4mg/mL - - heparin - - - 0.1mg/mL 0.1mg/mL 0.1mg/mL 0.1mg/mL Thiamine - - - - 0.4mg/mL 0.4mg/mL 0.4mg/mL Riboflavin - - - - 0.4mg/mL 0.4mg/mL 0.4mg/mL pyridoxal - - - - - 0.1mg/mL - Sinthol AMD - - - - - 0.3mg/mL - lecithin - - - - - - 0.1mg/mL flavonols - - - - - - 0.1mg/mL Cucurbitin - - - - - - 0.01mg/mL

<Experimental example>

Semen from a 32-year-old male was collected. And 0.5 mg of each of the compositions according to the control group, the comparative example, and Preparation Examples 1 to 5 was mixed and photographed with a microscope. And the microscope image in the state after 30 minutes is shown in FIG.

Referring to FIG. 1 , in the case of the sperm according to the control group, it was confirmed that the number of surviving sperm was significantly small. In addition, although not represented in the drawings, in the case of Preparation Examples 1 to 5, it was confirmed that the movement and movement speed of sperm were significantly higher than that of the control group.

In addition, the movement speed of sperm after 30 minutes was compared with the movement speed of 1 minute immediately after mixing, as shown in FIG. 2 . The movement speed of sperm was ㎛/sec. Referring to FIG. 2 , in the control group, the movement speed of sperm slightly decreased over time, whereas in the rest of the group, the movement speed of sperm increased slightly. Cellulose and fructose are thought to impart motility to sperm. When comparing the Comparative Example and the Preparation Example, it can be seen that the increase in the movement speed of the sperm is significantly higher in the Preparation Examples compared to the Comparative Example.

In addition, the survival rate of sperm was calculated by counting the number of sperm moving within a predetermined test target area at a time point 24 hours after mixing, and this is shown in FIG. 3 . Referring to FIG. 3 , it can be seen that, in the control group, the survival rate of sperm was only about 54%, whereas in the case of the preparation examples, the survival rate was 80% or more.

In the above, the embodiment of the present invention has been mainly described, but this is only an example and does not limit the present invention. It will be appreciated that various modifications and applications not exemplified above are possible.

Therefore, it should be understood that the scope of the present invention includes changes, equivalents or substitutes of the technical ideas exemplified above. For example, each component specifically shown in the embodiment of the present invention may be implemented by modification. And the differences related to these modifications and applications should be construed as being included in the scope of the present invention defined in the appended claims.

Claims (8)

Purified water; PBS; fructose (fructose, C ₆ H ₁₂ O ₆ ) 0.2 mg/mL to 5.0 mg/mL; heparin 0.01 mg/mL to 0.1 mg/mL; thiamin 0.2 mg/mL to 0.5 mg/mL; riboflavin 0.2 mg/mL to 0.5 mg/mL; lecithin 0.01 mg/mL to 0.2 mg/mL; Cucurbitin 0.01 mg/mL to 0.05 mg/mL; and guar gum, wherein the lubricating composition is free of cellulose. delete delete delete delete delete delete delete

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