KR102454273B1 - Vascular hemostasis member - Google Patents

Abstract

The present invention relates to a vascular hemostatic member including nanofibers made of a TECA component that inserts nanofibers including deca (TECA) into a blood vessel perforation to close the perforation and suppress bleeding. The first adhesive thin film for blocking vascular perforation according to an embodiment of the present invention, a central yarn that penetrates the center of the first adhesive thin film and is inserted into the blood vessel from the outside of the blood vessel, and a radial short fiber connected to the central yarn and surrounding the central yarn includes wealth.

Description

Absence of vascular hemostasis {VASCULAR HEMOSTASIS MEMBER}

The present invention relates to a vascular hemostatic member comprising nanofibers made of a TECA component. Specifically, it relates to a vascular hemostatic member that inserts nanofibers including TECA into the vascular perforation to close the perforation and suppress bleeding.

Since coronary stents or angiography are performed on coronary arteries with high blood pressure, perforation occurs at the insertion site after the procedure. Due to the high blood pressure, excessive blood is discharged due to the high blood pressure, and it is difficult to stop hemostasis by itself.

Manual compression is a procedure that compresses surrounding tissues, and the patient's movements are limited for more than 6 to 12 hours after the procedure, and the procedure time and success rate vary depending on the situation. Manual vascular occlusion is a method using a hemostatic pad or a compression member containing a coagulant, and has an unclear advantage over other methods in terms of shortening hemostasis time and effectiveness.

On the other hand, active vascular occlusion is a method of simultaneously compressing the inner and outer walls of a blood vessel using a catheter or the like, or compressing a coagulant to the outer wall to stop hemostasis. However, active vascular occlusion has a problem in that it requires complicated devices and high skill is required to use the devices.

Republic of Korea Patent No. 10-0554519 (registered on Feb. 16, 2006)

The present invention has been devised to solve the above problems, and the present invention provides an excellent vascular hemostatic member with a simplified structure that enables hemostasis by preventing vascular perforation without requiring high skill of the operator, unlike the prior art. is to provide

The vascular hemostatic member according to an embodiment of the present invention penetrates the center of the first adhesive thin film and the first adhesive thin film for blocking the vascular perforation, and is connected to the central yarn and the central yarn inserted into the blood vessel from the outside of the blood vessel and surrounds the central yarn. includes a radial short fiber portion.

In addition, the central yarn part and the short fiber part may be nanofibers containing collagen, PLGA, and deca (TECA), and the central yarn part and the short fiber part may include 1 wt% to 3 wt% of deca (TECA), and the central yarn part and The diameter of the short fiber portion may be in the range of 2.15 μm to 3.22 μm.

In addition, it may further include a second adhesive thin film fixed to one end of the central yarn portion and to which the central yarn portion and the short fiber portion are connected.

In addition, it may further include an external closure fixed to the skin surface.

In addition, the central yarn portion may include a plurality of central yarns, and the short fiber portion may include a plurality of short fibers.

In addition, it may include a third adhesive thin film fixed to one end of the central yarn portion and to which the plurality of central yarns and the plurality of short fibers are connected.

The vascular hemostatic member according to the embodiment of the present invention can easily prevent vascular perforation even if the operator's skill level is not high with a simplified configuration.

In addition, the vascular hemostatic member according to an embodiment of the present invention may be expanded in the vascular perforation by a component including nanofibers including collagen and deca (TECA), thereby preventing bleeding.

In addition, the vascular hemostatic member according to an embodiment of the present invention may include an adhesive thin film to prevent detachment of tangled fibers from the inside of the blood vessel.

In addition, the vascular hemostatic member according to an embodiment of the present invention may include an external closure to be double sealed inside and outside the vascular perforation.

In addition, the vascular hemostatic member according to an embodiment of the present invention may include a plurality of central yarns and a plurality of short fibers to compress hemostasis of the vascular perforation even when the size of the vascular perforation is large.

1 is a diagram schematically illustrating a vascular hemostatic member according to an embodiment of the present invention.
2 is a view schematically illustrating a vascular hemostatic member according to a first embodiment of the present invention.
Figure 3 is an image showing the results of testing the concentration and diameter of the nanofiber deca (TECA) suitable for the vascular hemostatic member of the present invention.
4 is a view schematically illustrating a vascular hemostatic member according to a second embodiment of the present invention.
5 is a view schematically illustrating a vascular hemostatic member according to the third and fourth embodiments of the present invention.
6 is a view schematically illustrating a vascular hemostatic member according to a fifth embodiment of the present invention.
7 is a view schematically illustrating a vascular hemostatic member according to a sixth embodiment of the present invention.
8 is a view schematically illustrating a vascular hemostatic member according to seventh and eighth embodiments of the present invention.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, only these embodiments allow the disclosure of the present invention to be complete, and common knowledge in the technical field to which the present invention belongs It is provided to fully inform the possessor of the scope of the invention, and the present invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout.

Although first, second, etc. are used to describe various elements, components, and/or sections, it should be understood that these elements, components, and/or sections are not limited by these terms. These terms are only used to distinguish one element, component, or sections from another. Accordingly, it goes without saying that the first element, the first element, or the first section mentioned below may be the second element, the second element, or the second section within the spirit of the present invention.

The terminology used herein is for the purpose of describing the embodiments and is not intended to limit the present invention. In this specification, the singular also includes the plural, unless specifically stated otherwise in the phrase. As used herein, "comprises" and/or "made of" refers to a referenced component, step, operation and/or element of one or more other components, steps, operations and/or elements. The presence or addition is not excluded.

Unless otherwise defined, all terms (including technical and scientific terms) used herein may be used with the meaning commonly understood by those of ordinary skill in the art to which the present invention belongs. In addition, terms defined in a commonly used dictionary are not to be interpreted ideally or excessively unless clearly defined in particular.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

1 is a diagram schematically illustrating a vascular hemostatic member according to an embodiment of the present invention.

2 is a view schematically illustrating a vascular hemostatic member according to a first embodiment of the present invention. 2A is a view schematically showing that the vascular hemostatic member according to the first embodiment of the present invention is inserted into the blood vessel through the blood vessel perforation. Figure 2b is a view schematically showing blocking the vascular perforation by the vascular hemostatic member according to the first embodiment of the present invention.

Figure 3 is an image showing the results of testing the concentration and diameter of the nanofiber deca (TECA) suitable for the vascular hemostatic member of the present invention.

Referring to FIG. 1 , the vascular hemostatic member 100 (hereinafter referred to as vascular hemostatic member) including nanofibers made of Deca (TECA) component according to the present embodiment includes a first adhesive thin film 110 and a central yarn part 120 . and a short fiber part 130 .

The first adhesive thin film 110 may prevent vascular perforation and may be attached to the surface of the skin 10 . The first adhesive thin film 110 may be a thin thin film made of nanofibers containing components such as a regeneration accelerator, an antibiotic, an anti-inflammatory agent, TECA, and the like, and may be a patch having adhesiveness to be attached to the surface of the skin 10 . .

The central yarn part 120 penetrates the center of the first adhesive thin film 110 , and may be inserted into the blood vessel 20 from the outside of the blood vessel 20 . The short fiber unit 130 may include a radial short fiber connected to the central yarn unit 120 and surrounding the central yarn unit 120 .

Therefore, the present invention can provide a simplified vascular hemostatic member that can easily prevent vascular perforation even if the skill of the operator is not high. In addition, since it contains a TECA component, it has an excellent vascular regenerating function, and may be capable of more effective vascular hemostasis.

Referring to FIG. 2A , the central yarn part 120 and the short fiber part 130 may be inserted into the blood vessel 20 by the catheter 30 .

The central yarn part 120 and the short fiber part 130 may be nanofibers including collagen, PLGA, and TECA. Specifically, the central yarn portion 120 and the short fiber portion 130 include 1 wt% to 3 wt% of deca (TECA), and the diameter of the central yarn portion 120 and the short fiber portion 130 is 2.15 μm to 3.22 μm. can be

Referring to FIG. 3 , as the content of deca (TECA) increases, the diameter of the nanofiber decreases, and when the content of deca (TECA) is 5 wt% or more, it can be seen that the nanofiber formation is not well. Therefore, it can be seen that the nanofiber suitable for the vascular hemostatic member is most suitable when the content of TECA is 1wt% to 3wt%, and the most suitable when the diameter is 2.15㎛ to 3.22㎛.

Referring to FIG. 2B , the central yarn portion 120 and the short fiber portion 130 inserted into the blood vessel 20 by pulling the central yarn portion 120 connected out of the skin 10 are tangled with each other and the tangled fibers 132 ) can be formed. The entangled fibers 132 may cover the vessel wall 22 and the vessel perforation and may obstruct the vessel perforation. Collagen and Deca (TECA) components included in the tangled fibers 132 may expand by reaction with body fluid, thereby preventing bleeding by compression hemostasis.

4 is a view schematically illustrating a vascular hemostatic member according to a second embodiment of the present invention. 4A is a view schematically showing that the vascular hemostatic member according to the second embodiment of the present invention is inserted into the blood vessel through the blood vessel perforation. Figure 4b is a view schematically showing blocking the vascular perforation by the vascular hemostatic member according to the second embodiment of the present invention.

4A and 4B , the vascular hemostatic member 200 according to the second embodiment of the present invention includes a first adhesive thin film 110 , a second adhesive thin film 212 , a central yarn part 120 and a short fiber part. 130 may be included.

Here, the first adhesive thin film 110, the central yarn part 120 and the short fiber part 130 according to the second embodiment of the present invention are the first adhesive thin film 110, the center according to the first embodiment of the present invention. Since the yarn part 120 and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The second adhesive thin film 212 may be fixed to one end of the central yarn portion 120 , and may be connected to the central yarn portion 120 and the short fiber portion 130 . The second adhesive thin film 212 may be formed of the same material as the first adhesive thin film 110 .

Referring back to Figure 4b, the central yarn portion 120 and the short fiber portion 130 inserted into the blood vessel 20 due to the pulling of the central yarn portion 120 connected out of the skin 10 are tangled with each other and the fibers ( 132) may be formed. The second adhesive membrane 212 may be connected to the entangled fibers 132 to prevent the entangled fibers 132 from detaching from the vessel wall 22 and the vascular perforation.

Accordingly, the vascular hemostatic member according to the second embodiment of the present invention can prevent the fibers 132 entangled by blood flow by the second adhesive thin film 212 from being detached from the vascular wall 22 and the vascular perforation. In addition, since the first adhesive thin film 110 and the second adhesive thin film 212 can be double sealed inside and outside the vascular perforation, the vascular regeneration function can be improved.

5 is a view schematically illustrating a vascular hemostatic member according to the third and fourth embodiments of the present invention. 5A is a diagram schematically illustrating that the external closure of the vascular hemostatic member is attached to the skin surface according to the third embodiment of the present invention. 5B is a diagram schematically illustrating that the external closure of the vascular hemostatic member is attached to the skin surface according to the fourth embodiment of the present invention.

Referring to FIG. 5A , the vascular hemostatic member 300 according to the third embodiment of the present invention includes a first adhesive thin film 110 , a central yarn part 120 , a short fiber part 130 , and an external closure 340 . can do.

Here, the first adhesive thin film 110, the central yarn part 120 and the short fiber part 130 according to the third embodiment of the present invention are the first adhesive thin film 110, the center according to the first embodiment of the present invention. Since the yarn part 120 and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The outer closure 340 may be fixed to the surface of the skin 10 , and in detail, may be attached to the surface of the skin 10 so as to cover the first adhesive thin film 110 . The outer closure 340 may be in the form of a patch including a TECA component.

The vascular hemostatic member 300 according to the third embodiment of the present invention can prevent detachment of the first adhesive thin film 110 by attaching the external closure 340 on the first adhesive thin film 110 . In addition, since the vascular perforation can be compressed with the first adhesive thin film 110 and the external closure 340 , a separate bandage or fixing device may not be required.

Referring to FIG. 5B , the vascular hemostatic member 400 according to the fourth embodiment of the present invention includes a first adhesive thin film 110 , a second adhesive thin film 212 , a central yarn part 120 , and a short fiber part 130 . and an outer closure 440 .

Here, the first adhesive thin film 110 , the second adhesive thin film 212 , the central yarn part 120 and the short fiber part 130 according to the fourth embodiment of the present invention are the first adhesive thin films according to the second embodiment of the present invention. Since the first adhesive thin film 110 , the second adhesive thin film 212 , the central yarn part 120 , and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The outer closure 440 may be fixed to the surface of the skin 10 , and in detail, may be attached to the surface of the skin 10 so as to cover the first adhesive thin film 110 . The outer closure 440 may be in the form of a patch including a TECA component.

In the vascular hemostatic member 400 according to the fourth embodiment of the present invention, the outer closure 440, the first adhesive thin film 110 and the second adhesive thin film 212 can be double sealed inside and outside of the vascular perforation. Thus, it is possible to prevent the tangled fibers 132 from being detached from the inside of the blood vessel. In addition, it is possible to shorten the hemostasis time due to the high effect of compressing the vascular perforation.

6 is a view schematically illustrating a vascular hemostatic member according to a fifth embodiment of the present invention. 6A is a view schematically showing that the vascular hemostatic member according to the fifth embodiment of the present invention is inserted into the blood vessel through the blood vessel perforation. 6B is a diagram schematically illustrating blocking of vascular perforation by a vascular hemostatic member according to a fifth embodiment of the present invention.

Referring to FIG. 6A , the vascular hemostatic member 500 according to the fifth embodiment of the present invention may include a first adhesive thin film 110 , a central yarn part 120 , and a short fiber part 130 .

Here, the first adhesive thin film 110, the central yarn part 120 and the short fiber part 130 according to the fifth embodiment of the present invention are the first adhesive thin film 110, the center according to the first embodiment of the present invention. Since the yarn part 120 and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The central yarn part 120 may include a plurality of central yarns 120a, 120b, and 120c.

The short fiber unit 130 may include a plurality of short fibers 130a, 130b, and 130c.

The plurality of central yarns 120a, 120b, and 120c and the plurality of short fibers 130a, 130b, and 130c may be connected to the first adhesive thin film 110 and inserted into the blood vessel 20 .

Referring to FIG. 6B , the plurality of central yarns 120a, 120b, and 120c connected to the outside of the skin 10 are pulled into the blood vessel 20 by pulling the plurality of central yarns 120a, 120b, and 120c and the plurality of steps. The fibers 130a, 130b, and 130c may be entangled with each other to form the entangled fibers 132 . The entangled fibers 132 may cover the vessel wall 22 and the vessel perforation and may obstruct the vessel perforation.

Therefore, in the vascular hemostatic member 500 according to the fifth embodiment of the present invention, a plurality of central yarns 120a, 120b, 120c and a plurality of short fibers 130a, 130b, 130c are entangled in the tangled fibers 132. Since single central yarns and short fibers can be more dense than the tangled fibers formed by entanglement, it can be suitably applied to areas with large vascular perforation. In addition, the entangled fibers 132 can compress and seal the vessel wall 22 and the vessel perforation, thereby enhancing the effect of vascular hemostasis.

7 is a view schematically illustrating a vascular hemostatic member according to a sixth embodiment of the present invention. 7A is a view schematically showing that the vascular hemostatic member according to the sixth embodiment of the present invention is inserted into the blood vessel through the blood vessel perforation. 7B is a diagram schematically illustrating blocking of vascular perforation by a vascular hemostatic member according to a sixth embodiment of the present invention.

7A and 7B , the vascular hemostatic member 600 according to the sixth embodiment of the present invention includes a first adhesive thin film 110 , a third adhesive thin film 312 , a central yarn part 120 , and a short fiber part. 130 may be included.

Here, the first adhesive thin film 110, the central yarn part 120 and the short fiber part 130 according to the sixth embodiment of the present invention are the first adhesive thin film 110, the center according to the fifth embodiment of the present invention. Since the yarn part 120 and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The third adhesive thin film 312 may be fixed to one end of the central yarn part 120 and may be connected to the plurality of central yarns 120a, 120b, and 120c and the plurality of short fibers 130a, 130b, and 130c. The third adhesive thin film 312 may be formed of the same material as the first adhesive thin film 110 or the second adhesive thin film 212 .

Referring back to Figure 7b, the plurality of central yarns (120a, 120b, 120c) connected out of the skin 10 are pulled into the blood vessel 20 by pulling the plurality of central yarns (120a, 120b, 120c) and the plurality of The short fibers 130a, 130b, and 130c may be entangled with each other to form the tangled fibers 132 . The third adhesive membrane 312 may be connected to the entangled fibers 132 to prevent the entangled fibers 132 from detaching from the vessel wall 22 and the vessel puncture.

Therefore, in the vascular hemostatic member 600 according to the sixth embodiment of the present invention, the plurality of central yarns 120a, 120b, and 120c and the plurality of short fibers 130a, 130b, 130c are entangled to prevent vascular perforation. Perforations can be applied to large areas. In addition, the third adhesive thin film 312 may be attached to the entangled fibers 132 to prevent the entangled fibers 132 from being detached from the vessel wall 22 and the vascular perforation due to blood flow.

8 is a view schematically illustrating a vascular hemostatic member according to seventh and eighth embodiments of the present invention. 8A is a diagram schematically illustrating that the external closure of the vascular hemostatic member is attached to the skin surface according to the seventh embodiment of the present invention. 8B is a view schematically illustrating that the external closure of the vascular hemostatic member is attached to the skin surface according to the eighth embodiment of the present invention.

Referring to FIG. 8A , the vascular hemostatic member 700 according to the seventh embodiment of the present invention includes a first adhesive thin film 110 , a central yarn part 120 , a short fiber part 130 , and an external closure 540 . can do.

Here, the first adhesive thin film 110, the central yarn part 120 and the short fiber part 130 according to the seventh embodiment of the present invention are the first adhesive thin film 110, the center according to the fifth embodiment of the present invention. Since the yarn part 120 and the short fiber part 130 have the same configuration and the same components, a detailed description will be omitted below.

The outer closure 540 may be fixed to the surface of the skin 10 , and in detail, may be attached to the surface of the skin 10 so as to cover the first adhesive thin film 110 . The outer closure 540 may be in the form of a patch including a TECA component.

The vascular hemostatic member 700 according to the seventh embodiment of the present invention may prevent detachment of the first adhesive thin film 110 by attaching the external closure 540 on the first adhesive thin film 110 . In addition, due to the first adhesive thin film 110 and the external closure 540, the vascular perforation can be compressed more than the case without the external closure 540, thereby reducing the hemostasis time.

Referring to FIG. 8B , the vascular hemostatic member 800 according to the eighth embodiment of the present invention includes a first adhesive thin film 110 , a central yarn part 120 , a short fiber part 130 , and a third adhesive thin film 312 . and an outer closure 640 .

Here, the first adhesive thin film 110, the central yarn part 120, the short fiber part 130 and the third adhesive thin film 312 according to the eighth embodiment of the present invention are the first adhesive thin films according to the sixth embodiment of the present invention. Since the first adhesive thin film 110 , the central yarn part 120 , the short fiber part 130 , and the third adhesive thin film 312 have the same configuration and the same components, a detailed description thereof will be omitted below.

The outer closure 640 may be fixed to the surface of the skin 10 , and in detail, may be attached to the surface of the skin 10 so as to cover the first adhesive thin film 110 . The outer closure 640 may be in the form of a patch including a TECA component.

In the vascular hemostatic member 800 according to the eighth embodiment of the present invention, the outer closure 640 , the first adhesive thin film 110 and the third adhesive thin film 312 can be double sealed inside and outside the vascular perforation. This may further increase the pressure of the vascular perforation.

Although the above has been described with reference to the embodiments of the present invention, those of ordinary skill in the art to which the present invention pertains can understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential features. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.

10: skin 20: blood vessels
22: vessel wall 30: catheter
100: vascular hemostatic member 110: first adhesive thin film
212: second adhesive thin film 312: third adhesive thin film
120: central yarn 130: short fiber portion
132: tangled fibers 340: outer closure

Claims (6)

A first adhesive thin film to prevent vascular perforation;
a central yarn penetrating through the center of the first adhesive thin film and inserted into the blood vessel from outside the blood vessel;
a radial short fiber portion connected to the central yarn portion and surrounding the central yarn portion; and
and an external closure fixed to the skin surface so as to cover the first adhesive thin film,
As the central yarn extending out of the skin is pulled, the central yarn and the short fiber inserted into the blood vessel are entangled with each other to form tangled fibers, and the tangled fibers cover the vessel wall and the vessel perforation to perforate the vessel. to occlude, the absence of vascular hemostasis. According to claim 1,
The central yarn part and the short fiber part are nanofibers containing collagen, PLGA, and TECA (Titrated extract of Centella asiatica), which is a quantitative extract of Centella asiatica,
The central yarn part and the short fiber part include 1 wt% to 3 wt% of Deca (TECA),
The diameter of the central yarn portion and the short fiber portion is 2.15㎛ ~ 3.22㎛, vascular hemostatic member. 3. The method of claim 2,
The vascular hemostatic member further comprising a second adhesive thin film fixed to one end of the central yarn portion and connected to the central yarn portion and the short fiber portion. delete According to claim 1,
The central yarn portion includes a plurality of central yarns,
The vascular hemostatic member comprising a plurality of short fibers. 6. The method of claim 5,
and a third adhesive thin film fixed to one end of the central yarn and connected to the plurality of central yarns and the plurality of short fibers.

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