KR102440716B1 - System and method for providing optimal model of porous structure for implant - Google Patents

Abstract

The system for implementing the optimal model of the porous structure for implant according to the present invention is a system for implementing the optimal model of the porous structure formed on the surface of the implant for implantation, and the first cross-section of the cancellous bone for a specific bone of the human body - The first cross-section is a cross-section in a direction perpendicular to the direction in which the biological load of the human body is applied to the cancellous bone - based on the information of the first air gap provided on the xz cross-section and the first void information provided on the yz cross-section 2 The air gap information storage unit storing the information of the air gap - The axis with respect to the direction in which the biological load of the human body is applied to the cancellous bone is the z axis, and the axis with respect to the direction perpendicular to the z axis on the first cross section is the x axis, an axis perpendicular to the x-axis and the z-axis is the y-axis; and generating a random point in the parent space having a predetermined volume, forming a three-dimensional primary pore unit using the principle of a Voronoi diagram based on the generated random point, and forming the first pore information and the second 2 An optimal model derivation unit for deriving an optimal model of the porous structure by processing the three-dimensional primary pore unit into an optimal pore unit based on the information on the second pore; may be characterized in that it comprises.

Description

System and method for providing optimal model of porous structure for implant

The present invention relates to a system and method for implementing an optimal model of a porous structure for implants that can be used to form an optimal porous structure that improves osseointegration in an implant for bio-insertion.

Recently, as we enter an aging society, the incidence of arthritis is increasing, and diseases such as degenerative arthritis are rapidly increasing due to an increase in an increasing number of obese people.

Due to this, the market size of the artificial joint is growing, and interest in technologies such as personalized artificial joints and porous surface treatment is increasing in order to minimize side effects such as complications.

Here, the artificial joint may be represented by an orthopedic implant, and the orthopedic implant generally promotes bone growth, ie, osteogenesis and osseointegration, through coating of a porous structure on an implant base.

Here, the porous coating layer formed on the surface of the implant base has the thickness of the coating layer, the size of the pores in the coating layer, the porosity and the shape of the pores, as disclosed in Korean Patent No. 10-1109086, in order to promote osteogenesis and osseointegration, etc. Manufactured under control.

However, despite the control of the thickness of the coating layer, the size of the pores in the coating layer, the porosity and the shape of the pores, the pore structure of the porous coating layer formed on the surface of the conventional implant base is significantly different from the pore structure of cancellous bone for specific bones of the human body. Due to the difference, there is still a problem that osteogenesis and osseointegration are not actively induced.

Therefore, there is an urgent need to study for preparing a porous coating layer having an optimal structure substantially similar to the shape of the cavity of cancellous bone for specific bones of the human body.

It is an object of the present invention to provide a system and method for implementing an optimal model of a porous structure for an implant used to manufacture an implant having a porous structure that is maximally similar to the porous structure of cancellous bone for a specific bone of the human body.

The system for implementing the optimal model of the porous structure for implant according to the present invention is a system for implementing the optimal model of the porous structure formed on the surface of the implant for implantation, and the first cross-section of the cancellous bone for a specific bone of the human body - The first cross-section is a cross-section in a direction perpendicular to the direction in which the biological load of the human body is applied to the cancellous bone - based on the information of the first air gap provided on the xz cross-section and the first void information provided on the yz cross-section 2 The air gap information storage unit storing the information of the air gap - The axis with respect to the direction in which the biological load of the human body is applied to the cancellous bone is the z axis, and the axis with respect to the direction perpendicular to the z axis on the first cross section is the x axis, an axis perpendicular to the x-axis and the z-axis is the y-axis; and generating a random point in the parent space having a predetermined volume, forming a three-dimensional primary pore unit using the principle of a Voronoi diagram based on the generated random point, and forming the first pore information and the second 2 An optimal model derivation unit for deriving an optimal model of the porous structure by processing the three-dimensional primary pore unit into an optimal pore unit based on the information on the second pore; may be characterized in that it comprises.

The information of the first void of the system for implementing the optimal model of the porous structure for implant according to the present invention is by matching a circle or an ellipse to the void provided on the xz cross-section, and the xz cross-section for the matched circle or ellipse and first ratio distribution information, which is distribution information about the ratio of the major axis to the minor axis, and first angle distribution information, which is information about the angular distribution of the z-axis and the major axis on the xz section, The information includes second ratio distribution information that is distribution information about the ratio of the major axis and the minor axis on the yz section to the matched circle or ellipse by matching the void provided on the yz section with a circle or an ellipse, and the z It may be characterized in that it includes second angle distribution information, which is information about an angle distribution of an axis and a major axis on the yz section.

The random points generated in the parent space of the system for implementing the optimal model of the porous structure for implants according to the present invention are the number of circles or ellipses matching the voids provided on the xz section, and provided on the yz section It may be characterized in that it is set based on the number of circles or ellipses matching the voids.

The optimal model derivation unit of the system for implementing the optimal model of the porous structure for implants according to the present invention changes the volume by applying the first ratio distribution information and the second ratio distribution information to the three-dimensional primary pore unit and changing the degree of inclination with respect to the z-axis by applying the first angle distribution information and the second angle distribution information, characterized in that the three-dimensional primary pore unit is processed into a secondary pore unit. can

The optimal model derivation unit of the system for implementing the optimal model of the porous structure for implant according to the present invention processes the edge so that the edge of the secondary pore unit is curved, and converts the secondary pore unit into the tertiary pore unit. It may be characterized by processing with

The optimal model derivation unit of the system for implementing the optimal model of the porous structure for implant according to the present invention fills the space existing between the tertiary pore units to correspond to the bone part of the cancellous bone, and the tertiary pore unit It may be characterized in that the tertiary pore unit is processed so that it becomes a spatialized quaternary pore unit.

The optimal model derivation unit of the system for implementing the optimal model of the porous structure for implant according to the present invention corresponds to the shape of the first cross-section of the cancellous bone when the fourth pore unit is formed By processing as possible, it may be characterized in that an optimal model of the porous structure in which the fourth pore unit is processed into the optimal pore unit is derived.

According to the system and method for implementing the optimal model of the porous structure for implants according to the present invention, it is possible to implement an optimal model of the porous structure that is maximally similar to the porous structure of the cancellous bone for a specific bone of the human body.

In addition, due to the implementation of the optimal model of the porous structure, the implant for bio-insertion manufactured on the basis of the implant may be effective in treating a patient's disease by improving osteogenesis and osseointegration.

1 is a block diagram for explaining a system for implementing an optimal model of a porous structure for implants according to the present invention.
Figure 2 is a flow chart for a method for implementing the optimal model of the porous structure for implants according to the present invention.
Figure 3 is a first cross-sectional view of the knee spongy bone of the human body.
Fig. 4 is an xz cross-sectional view taken along line AA of Fig. 3;
Figure 5 is an enlarged view of part A of Figure 4;
Fig. 6 is a yz cross-sectional view taken along line BB of Fig. 4;
Fig. 7 is an enlarged view of part B of Fig. 6;
8 is a view for explaining a process of forming a three-dimensional primary pore unit using the principle of the Voronoi diagram.
9 is a view for explaining a process in which a three-dimensional primary pore unit is processed into a secondary pore unit and a tertiary pore unit;
10 is a view for explaining a state in which a tertiary pore unit is processed into a quaternary pore unit;
11 is a view showing an optimal model of the porous structure derived by the present invention.

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the drawings. However, the spirit of the present invention is not limited to the presented embodiment, and those skilled in the art who understand the spirit of the present invention may add, change, delete, etc. other elements within the scope of the same spirit, through addition, change, deletion, etc. Other embodiments included within the scope of the invention may be easily suggested, but this will also be included within the scope of the invention.

In addition, components having the same function within the scope of the same idea shown in the drawings of each embodiment will be described using the same reference numerals.

1 is a block diagram illustrating a system for implementing an optimal model of a porous structure for implants according to the present invention.

Referring to FIG. 1 , a system 100 for implementing an optimal model of a porous structure for implant according to the present invention is a system for deriving an optimal model of a porous structure formed on the surface of an implant for bio-insertion, and a specific bone of the human body It may include a void information storage unit 110 for storing information on the cross-section of the cancellous bone for , and an optimum model derivation unit 120 for deriving an optimal model of the porous structure based on the information.

Here, the porous structure may be applied to the coating layer formed on the surface of the orthopedic implant, but is not limited thereto, and may be applied to any portion requiring the porous structure.

The void information storage unit 110 stores information on the first void provided on the xz cross-section and the second void information provided on the yz cross-section based on the first cross-section of the cancellous bone for a specific bone of the human body. It can be a component.

Here, the specific bone of the human body may be, for example, a knee bone, and the first cross-section is a cross-section (xy cross-section) in a direction perpendicular to a direction in which a biological load of the human body is applied to the cancellous bone as shown in FIG. 3 . can

The xz cross-section and the yz cross-section are cross-sections defined by an x-axis, a y-axis, and a z-axis on the first cross-section, and the z-axis is an axis with respect to a direction in which the biological load of the human body is applied to the cancellous bone, The x-axis is an axis in a direction perpendicular to the z-axis on the first cross-section, and the y-axis is the x-axis and an axis perpendicular to the z-axis.

Meanwhile, the first cross-section, the xz cross-section, and the yz cross-section may be obtained by Micro-CT, but are not limited thereto, and may be obtained by various tomography means.

The optimal model derivation unit 120 generates a random point in the parent space having a predetermined volume, forms a three-dimensional primary pore unit using the principle of the Voronoi diagram based on the generated random point, and the It may be a component for deriving an optimal model of the porous structure by processing the three-dimensional primary pore unit into an optimal pore unit based on the information of the first pore and the second pore information.

The output unit 130 may include a visual output module such as a display as a means for outputting the derived optimal model of the porous structure.

Hereinafter, a system 100 for implementing an optimal porous structure model for implants according to the present invention will be described while specifically explaining a method for implementing an optimal porous structure model for implants according to the present invention.

2 is a flowchart for a method for implementing an optimal model of a porous structure for implants according to the present invention.

First, the method for implementing the optimal model of the porous structure for implants according to the present invention is a concept including the operation by the system 100 for implementing the optimal model of the porous structure for implants according to the present invention.

Referring to Figure 2, the method for implementing the optimal model of the porous structure for implantation according to the present invention, a first step (S10) of obtaining information of the first void and the second void information of the cancellous bone, random in the maternal space A second step of generating a point (S20), a third step of forming a three-dimensional primary pore unit (S30), a fourth step of processing the primary pore unit to form a secondary pore unit (S40), A fifth step of processing the secondary pore unit to form a tertiary pore unit (S50), a sixth step of processing the tertiary pore unit to form a quaternary pore unit (S60), and the tertiary pore unit It may include a seventh step (S70) of deriving an optimal model of the porous structure using

Hereinafter, each step will be described in detail with reference to FIGS. 3 to 11 .

3 is a first cross-sectional view of the cancellous bone of the knee of the human body, FIG. 4 is an xz cross-sectional view taken along line AA of FIG. 3 , and FIG. 5 is an enlarged view of part A of FIG. 4 .

Also, FIG. 6 is a yz cross-sectional view taken along line BB of FIG. 4 , and FIG. 7 is an enlarged view of part B of FIG. 6 .

3 to 7, the first step (S10) is based on the first cross-section of the cancellous bone 210 for a specific bone of the human body, information of the first air gap provided on the xz section and on the yz section It may be a step of obtaining information of the provided second void.

Here, the information of the first void and the information of the second void are already stored in the void information storage unit 110 and may be obtained through the void information storage unit 110 , but the present invention is not limited thereto.

For example, the information of the first void and the information of the second void may be obtained by receiving input through a separate input means or may be acquired through communication using a network with a separate server that is already stored.

As shown in FIG. 5 , the information of the first void is obtained by matching a circle or an ellipse to the void provided on the xz cross-section, and the major axis AX1 and the minor axis AX2 on the xz cross-section for the matched circle or ellipse. .

The first ratio distribution information may be organized as a relationship of a distribution ratio (%) with respect to a specific ratio, and the first angle distribution information may be organized as a relationship of a distribution ratio (%) with respect to a specific angle.

The information of the second void is obtained by matching a circle or an ellipse to the void provided on the yz cross-section as shown in FIG. ) may include second ratio distribution information, which is distribution information about the ratio.

In addition, the information on the second gap may include second angle distribution information that is information about the angular distribution of the z-axis and the long axis AX3 on the yz cross-section.

The second ratio distribution information may be organized as a relationship of a distribution ratio (%) with respect to a specific ratio, and the second angle distribution information may be organized as a relationship of a distribution ratio (%) with respect to a specific angle.

8 is a view for explaining a process of forming a three-dimensional primary pore unit using the principle of the Voronoi diagram.

As described above, when the information of the first void and the second void information is obtained, the second step (S20) in which random points are generated in the mother space S having a predetermined volume by the optimal model derivation unit 120 proceeds ( 8(a) and 8(b))).

Here, the random point may be set based on the number of circles or ellipses matching the voids provided on the xz cross-section and the number of circles or ellipses matching the voids provided on the yz cross-section. It is not, and may be set based on medical statistical values.

When a random point is generated in the parent space (S) as described above, a three-dimensional primary pore unit using the principle of the Voronoi diagram based on the generated random point is formed by the optimal model derivation unit (120). Step 3 (S30) may proceed (refer to FIG. 8(c)).

The Voronoi diagram refers to a case in which, when there are points on a plane, a surface is divided into polygons including one point each, but a predetermined condition is satisfied. do.

9 is a view for explaining a process in which a three-dimensional primary pore unit is processed into a secondary pore unit and a tertiary pore unit.

When the three-dimensional primary pore unit E1 is formed using the principle of the Voronoi diagram, the first pore unit E1 is converted to the second pore unit E2 by the optimal model derivation unit 120 . A fourth step (S40) of processing may be performed.

In the fourth step (S40), the volume is changed by applying the first ratio distribution information and the second ratio distribution information to the three-dimensional primary pore unit E1, and the first angle distribution information and the second It may mean a step in which the three-dimensional primary pore unit E1 is processed into a secondary pore unit E2 by applying the second angle distribution information to change the degree of inclination with respect to the z-axis.

When the fourth step (S40) is performed, the volume of the three-dimensional primary pore unit E1 and the degree of inclination with respect to the z-axis are changed by a predetermined specific gravity.

When the fourth step (S40) is completed as described above, a fifth step (S50) in which the secondary pore unit E2 is processed into a tertiary pore unit E3 by the optimal model derivation unit 120 will proceed. can

The fifth step ( S50 ) is a step performed by the optimal model derivation unit 120 , and machining the corner so that the corner of the secondary pore unit E2 is curved, and the secondary pore unit E2 ) may be a step of processing the tertiary pore unit (E3).

Here, the processing of the corner is a factor for preventing the destruction of the void due to the corner when a biological load of the human body is applied to the cancellous bone 210, and at the same time to further match the shape of the void actually formed in the cancellous bone 210 to be.

10 is a view for explaining a state in which the tertiary pore unit is processed into a quaternary pore unit, and FIG. 11 is a view showing an optimal model of the porous structure derived by the present invention.

Referring to FIG. 10 , the space SP existing between the tertiary pore units is filled with a predetermined material to correspond to the bone portion of the cancellous bone 210 , and the tertiary pore unit E3 is spaced. A sixth step (S60) in which the tertiary pore unit E3 is processed in the optimal model derivation unit 120 may be performed so as to become a fourth pore unit E4.

Here, the spatialization may mean that the third pore unit E3 is transformed into a space.

11, when the sixth step (S60) of forming the fourth pore unit E4 is completed, the quaternary pore unit E4 is converted into the cancellous bone ( 210), a seventh step (S70) of deriving an optimal model M of the porous structure in which the fourth pore unit E4 is processed into an optimal pore unit is processed to correspond to the shape of the first cross-section. can

Here, although FIG. 11 shows a state processed in the form of a simple cylinder, this is only an example, and may be processed into a shape corresponding to the shape of the actual cancellous bone 210 .

On the other hand, when the optimal model M of the porous structure is derived by the seventh step (S70), the eighth step (S80) outputted through the output unit 130 may proceed.

As described above, the system 100 for implementing the optimal model of the porous structure for implants according to the present invention and the optimal model of the porous structure derived by the method are maximally similar to the porous structure of cancellous bone for a specific bone of the human body. , because of this, implants manufactured based on the optimal model are excellent in aspects such as bone growth and osseointegration, and thus can be effective in treating diseases of patients.

In the above, the configuration and features of the present invention have been described based on the embodiments according to the present invention, but the present invention is not limited thereto, and it is understood that various changes or modifications can be made within the spirit and scope of the present invention. It is intended that such changes or modifications will be apparent to those skilled in the art, and therefore fall within the scope of the appended claims.

100: A system for implementing an optimal model of a porous structure for implants
110: void information storage unit
120: optimal model derivation unit
130: output unit

Claims (7)

In the system for implementing the optimal model of the porous structure formed on the surface of the implant for bio-insertion,
A first cross-section of the cancellous bone for a specific bone of the human body - The first cross-section is a cross-section in a direction perpendicular to the direction in which the biological load of the human body is applied to the cancellous bone - The first cross-section provided on the xz cross-section A void information storage unit storing information on the first void and the second void information provided on the yz section - The axis with respect to the direction in which the biological load of the human body is applied to the cancellous bone is the z-axis, and the z-axis on the first section An axis with respect to a direction perpendicular to is an x-axis, and an axis perpendicular to the x-axis and the z-axis is a y-axis; and
Create a random point in the parent space having a predetermined volume,
Based on the generated random points, a three-dimensional primary pore unit is formed using the principle of Voronoi diagram,
An optimal model derivation unit for deriving an optimal model of the porous structure by processing the three-dimensional primary pore unit into an optimal pore unit based on the information of the first pore and the second pore information A system for implementing an optimal model of the porous structure for implants.
According to claim 1,
The information of the first void is,
By matching a circle or an ellipse to the void provided on the xz section, first ratio distribution information, which is distribution information about the ratio of the major axis and the minor axis on the xz section to the matched circle or ellipse, and the z axis and the Includes first angle distribution information, which is information about the angle distribution of the major axis on the xz section,
The information of the second void is,
Second ratio distribution information that is distribution information about the ratio of the major axis and the minor axis on the yz section to the matched circle or ellipse by matching the void provided on the yz section with a circle or an ellipse, and the z axis and the A system for implementing an optimal model of a porous structure for implants, characterized in that it includes second angular distribution information, which is information about the angular distribution of the long axis on the yz section.
3. The method of claim 2,
A random point generated in the parent space is
The optimal model of a porous structure for implants, characterized in that it is set based on the number of circles or ellipses matching the voids provided on the xz cross-section, and the number of circles or ellipses matching the voids provided on the yz cross-section. system to implement.
3. The method of claim 2,
The optimal model derivation unit,
The volume is changed by applying the first ratio distribution information and the second ratio distribution information to the three-dimensional primary pore unit, and the first angle distribution information and the second angle distribution information are applied to the z-axis. A system for implementing an optimal model of a porous structure for implants, characterized in that the three-dimensional primary pore unit is processed into a secondary pore unit by changing the degree of inclination.
5. The method of claim 4,
The optimal model derivation unit,
A system for implementing an optimal model of a porous structure for implantation, characterized in that by processing the edge so that the edge of the secondary pore unit is curved, the secondary pore unit is processed into a tertiary pore unit.
6. The method of claim 5,
The optimal model derivation unit,
The tertiary pore unit is processed so that the space existing between the tertiary pore units is filled to correspond to the trough portion of the cancellous bone, and the tertiary pore unit becomes a spatialized quaternary pore unit, characterized in that A system for implementing an optimal model of a porous structure for implants.
7. The method of claim 6,
The optimal model derivation unit,
When the fourth pore unit is formed, the fourth pore unit is processed to correspond to the shape of the first cross-section of the cancellous bone, and the fourth pore unit is processed into the optimal pore unit of the porous structure A system for implementing an optimal model of the porous structure for implants, characterized in that the optimal model is derived.

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