KR102422259B1 - Composition for filing internal prosthesis comprising metal-organic framework and gel - Google Patents

Abstract

The present invention relates to a composition for filling an implantable implant comprising a metal-organic framework (MOF) and a gel, a composition for inserting the same, and a method for manufacturing the same, By making it easier to observe the rupture of the implant in the body compared to the implant filled with the composition not containing the skeleton, there is an excellent effect of preventing side effects due to the rupture of the implant.

Description

Composition for filling internal prosthesis comprising metal-organic framework and gel

Disclosed herein are a composition for filling an implant including a metal-organic framework (MOF) and a gel, a composition for inserting the same, and a method for manufacturing the same.

In general, during various clinical operations, after removing the lesion tissue or organ, an implant (or implant) is required to fill the dead space. At this time, the body insert is a material that can be permanently inserted into the human body. It can adjust the hardness and elasticity according to the application location and function, minimize the sense of heterogeneity, and minimize the risk of decay and leakage of the filler filled inside. will do

As an example of such a body implant, the artificial breast implant is for reconstruction of breast defects caused by diseases and accidents such as cancer, and cosmetic and plastic surgery due to deformity, and is three-dimensionally and anatomically for the purpose of replacing organs or tissues. is used as The implant is a product in the form of saline, hydro-gel, and silicone gel filled as a filler inside a pouch made of silicone that can be transplanted into an organ.

Basically, in the case of a silicone artificial breast, since it replaces the female breast tissue, it should be able to maintain the softness of the breast tissue in its texture. Therefore, the lower the viscosity or cohesive force of the silicone gel as a filler, and the thinner the shell, the more effective it is for performance.

However, silicone gels with low viscosity or cohesive strength will lower the safety of the product. Second-generation breast implants show a high rupture rate after insertion due to the low durability of the thin shell, and similarly, silicone gels with low viscosity or cohesive strength may cause extensive leakage of silicone gels after rupture of the implants. , it becomes difficult to remove the silicone gel once spilled. In particular, a silicone gel having a too low viscosity (a silicone gel having a viscosity that becomes flowable) is widely leaked into the body, and there is a possibility of serious side effects such as tissue necrosis due to the coating on organs after the outflow.

In addition, the silicone gel used as a filler contains a large amount of low molecular weight silicone oil components, and these oil components (low molecular weight silicone molecules) cause swelling of the silicone shell. This swelling of the shell causes a decrease in the strength and elasticity of the shell, which is directly related to the durability of the product.

And the swelling caused by the silicone gel further accelerates the leakage of the relatively low molecular weight silicon molecules contained in the silicone gel through the shell, and the leaking low molecular weight silicone molecules are still a substance whose safety in the body is not completely over. .

As a result, the present inventors completed the present invention by conducting a study on a composition for filling an implant that can easily detect the rupture of an implant inserted into the body. did.

KR 10-2014-096821 A US 2016/0089444 A1 US 2010/0100027 A1

In one aspect, an object of the present invention is to provide a composition for filling an implant for insertion into the body and capable of detecting the rupture of the implant.

In another aspect, an object of the present invention is to provide an implant for insertion into the body filled with the composition.

In another aspect, it is an object of the present invention to provide a method for preparing the composition.

In one aspect, the present invention, a metal-organic framework (metal-organic framework, MOF) and a gel (gel) to provide a composition for filling the implant for insertion into the body.

In another aspect, the present invention provides an implant for insertion into the body filled with the composition for filling.

In another aspect, the present invention provides a method for detecting whether or not the implantable implant is ruptured using the implantable implant filled with the composition for filling.

In another aspect, the present invention provides a method comprising the steps of: (1) manufacturing a filler comprising silicon and a metal-organic framework (MOF); and (2) mixing the gel with the filler of step (1).

The present invention relates to a composition for implantable implantation comprising a metal-organic framework (MOF) and a gel, compared to a composition for implantation containing no metal-organic framework filled with an implant. By making it easy to observe the rupture of the implant in the body, there is an excellent effect of preventing side effects due to the rupture of the implant.

1 is an implant (20% by weight MOF in FIG. 1) filled with a filling composition including a metal-organic framework and a gel according to an embodiment of the present invention, and a metal-organic framework for filling without the metal-organic framework; FIG. It is an X-ray image taken after inserting each of the implants filled with the composition (control group, silicone gel in FIG. 1) into the body.
2 is an implant (Containing 20% MOF in FIG. 2) filled with a composition for filling containing 20 wt% of a metal-organic framework and a gel according to an embodiment of the present invention and a metal-organic framework It is an X-ray image in which the implant (control group, silicone gel in FIG. 2) filled with the unfilled composition is implanted. 2A is an X-ray image immediately after implantation of the implant, B and C of FIG. 2 are X-ray images after rupture, and the red arrow indicates 20% by weight of metal according to an embodiment of the present invention - Refers to an implant filled with a filling composition including an organic framework and a gel.

Hereinafter, the present invention will be described in detail.

As used herein, the term "metal-organic framework (MOF)" is a three-dimensional It refers to a porous material that forms a structure, and various MOFs can be made according to the selection of metal ions and organic ligands. The MOF has a characteristic of being porous in that an empty space exists in the structure, and the size, porosity, three-dimensional structure, surface area, etc. of the pores can be designed in various ways depending on the type and bonding method of metal ions and organic ligands constituting the MOF. have. Due to this porosity, MOF has a very large surface area as well as an open pore structure, so it is possible to move a large amount of molecules or solvents compared to other known porous materials. There are many active sites), so it has the advantage of maximizing efficiency. In addition, the MOF is not easily deformed at a high temperature and has a hard skeleton, so it has excellent chemical stability and thermal stability.

In one aspect, the present invention provides a composition for filling an implant for insertion into the body, including a metal-organic framework (MOF) and a gel.

In one aspect of the present invention, the metal-organic framework comprises one or more metal ions selected from the group consisting of Al and Zr, and 4,4'-biphenyldicarboxylic acid (4,4'-biphenyldicarboxilic acid). ), benzene-1,4-dicarboxylic acid, 9,10-anthracenedicarboxylic acid, biphenyl-3,3,5, 5'-tetracarboxylic acid (biphenyl-3,3,5,5'-tetracarboxylic acid), biphenyl-3,4',5-tricarboxylic acid (biphenyl-3,4',5-tricarboxylic acid) , 5-bromoisophthalic acid (5-bromoisophthalic acid), 5-cyano-1,3-benzenedicarboxylic acid (5-cyano-1,3-benzenedicarboxylic acid), 2,2-diamino-4, 4'-stilbenedicarboxylic acid (2,2-diamino-4,4'-stilbenedicarboxylic acid), 2,5-diaminoterephthalic acid (2,5-diaminoterephthalic acid), 1,1,2,2-tetra (4-carboxylphenyl)ethylene (1,1,2,2-tetra(4-carboxylphenyl)ethylene), 2,5-dihydroxyterephthalic acid (2,5-dihydroxyterephthalic acid), 2,2-dinitro- 4,4-stilbenedicarboxylic acid (2,2-dinitro-4,4-stilbenedicarboxylic acid), 5-ethynyl-1,3-benzenedicarboxylic acid (5-ethynyl-1,3-benzenedicarboxylic acid) ), 2-hydroxyterephthalic acid, 2,6-naphthalenedicarboxylic acid, 1,2,4,5-tetrakis(4-carboxyphenyl)benzene ( 1,2,4,5-tetrakis(4-carboxyphenyl)benzene), 4,4,4″-s-triazine-2,4,6-triyl-tribenzoic acid (4,4,4″-s- triazine-2,4, 6-triyl-tribenzoic acid), 1,3,5-tricarboxybenzene (1,3,5-tricarboxybenzene), 1,4,7,10-tetraazacyclododecane-N,N',N'', N'''-tetraacetic acid (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid), 1,3,5-tris(4-carboxy[1, 1'-biphenyl]-4-yl)benzene (1,3,5-tris(4-carboxy[1,1′-biphenyl]-4-yl)benzene), 1,3,5-tris(4- At least one selected from the group consisting of carboxyphenyl)benzene (1,3,5-tris(4-carboxyphenyl)benzene), 1,3,5-triscarboxyphenylethynylbenzene (1,3,5-triscarboxyphenylethynylbenzene) organic ligands. Specifically, the metal-organic framework is MOF-808 (Zr ₆ O ₄ (OH) ₄ (BTC) ₂ (HCOO) ₆ ), MOF-801 (Zr ₆ O ₄ (OH) ₄ (fumarate) ₆ ), Zr ₆ O ₆ (BDC) ₆ , Zr ₆ O ₆ (NH- ₂ -BDC) ₆ , Zr ₆ O ₆ (OH) ₄ (BPDC) ₆ , Al ₃ O(OH)(H ₂ O) ₂ (BDC- It may be at least one selected from the group consisting of NH ₂ ) ₃ and Al(OH)(BDC), and more specifically, MOF-808 (Zr ₆ O ₄ (OH) ₄ (BTC) ₂ (HCOO) ₆ ). , The type of the metal-organic framework is not limited as long as it is included in the composition for filling the implant for insertion into the body to ensure safety and to observe the shape of the implant for insertion into the body.

In one aspect of the present invention, the gel may have cohesive force, and specifically may be a cohesive gel. The cohesive gel is a gel with high cohesive force, and is widely used as a filler in implants for insertion into the body. has the advantage of being able to minimize However, even if the implant is filled with high-viscosity cohesive gel, there is a problem that the gel leaks into the body due to the difference in molecular weight. For example, if breast augmentation is performed, careful observation is required for implant damage.

According to an embodiment of the present invention, the composition for filling the implant for insertion into the body including the metal-organic framework and the gel is included in the implant for insertion into the body, so that the form of the composition for filling (that is, the gel for filling) is, In contrast to the case in which the filling composition is not included, it can be clearly identified before and after rupture. Accordingly, even when the implant is in the body, the rupture can be easily observed by, for example, X-rays, thereby confirming that side effects due to the rupture of the implant can be prevented (eg, the experimental example below and FIG. 2 ).

In one aspect of the present invention, the composition may further include silicone.

In one aspect of the present invention, the silicone may be a silicone elastomer (silicone elastomer). The elastomer is a polymer having elasticity, also called an elastomer, and has elasticity so that it stretches when pulled by applying an external force, and returns to its original length when the external force is removed. It is known that this elasticity is due to the fact that the linear polymers are slid and lengthened as a whole, and the return when the force is removed is known to be due to the motion of the deformed molecules. The silicone elastomer is an elastomer containing silicone, and specifically, polysilicon-11, polymethylsilsesquioxane, dimethicone crosspolymer, dimethicone/vinyldimethicone crosspolymer (Dimethicone). /Vinyl Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Lauryl Dimethicone Crosspolymer, Dimethicone/Polyglycerin-3 Crosspolymer, Vinyl Dimethicone/Lauryl Dimethicone Crosspolymer, Diphenyl Dimethicone It may include at least one selected from the group consisting of diphenyl dimethicone/vinyl diphenyl dimethicone/silsesquioxane crosspolymer, and polydimethylsiloxane, more specifically It may be polymethylsiloxane, but the type is not limited as long as it is a silicone elastomer that can be safely included in the composition filled in the implant for insertion into the body.

In one aspect of the present invention, the metal-organic framework may be included in an amount of 1 to 40% by weight, specifically 2 to 20% by weight, based on the total weight of the silicone, gel, and the metal-organic framework. and more specifically 1 wt% or more, 1.5 wt% or more, 2 wt% or more, 2.5 wt% or more, 3 wt% or more, 3.5 wt% or more, 4 wt% or more, 4.5 wt% or more, 5 wt% or more, 6% or more, 7% or more, 8% or more, 9% or more, 10% or more, 11% or more, 12% or more, 13% or more, 14% or more, 15% or more, 16% or more, 17% or more, 18% or more, 19% or more, 20% or more, 21% or more, 22% or more, 23% or more, 24% or more, 25% or more, 26 wt% or more, 27 wt% or more, 28 wt% or more, 29 wt% or more, 30 wt% or more, 35 wt% or more, or 40 wt% or more, and 40 wt% or less, 35 wt% or less, 30 wt% or more % or less, 29% or less, 28% or less, 27% or less, 26% or less, 25% or less, 24% or less, 23% or less, 22% or less, 21% or less, 20% or less % or less, 19 wt% or less, 18 wt% or less, 17 wt% or less, 16 wt% or less, 15 wt% or less, 14 wt% or less, 13 wt% or less, 12 wt% or less, 11 wt% or less, 10 wt% or less % or less, 9 wt% or less, 8 wt% or less, 7 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, 3 wt% or less, or 2 wt% or less As the content of the metal-organic framework, which is the active ingredient of the composition filled in the implant, stability is guaranteed, and the shape of the implant can be identified from among the implants for insertion into the body. If there is an amount, it is not limited to the above range.

In one aspect of the present invention, the composition may be used after being cured. In addition, it may be cured by further including a curing agent component for curing.

The curing may be at 100 to 230° C. for 1 to 10 hours, and the curing temperature and time may vary depending on the type of silicone, gel, and metal-organic framework to be cured. In addition, it may vary depending on whether or not a curing agent is used and the type.

Specifically, the curing may be curing at 100 to 230 °C, more specifically 100 °C or higher, 110 °C or higher, 120 °C or higher, 130 °C or higher, 140 °C or higher, 150 °C or higher, 160 °C or higher, 165 °C or higher or higher, 170 °C or higher, 180 °C or higher, 190 °C or higher, 200 °C or higher, 210 °C or higher, or 220 °C or higher, and may be 230 °C or lower, 220 °C or lower, 210 °C or lower, 200 °C or lower, 190 °C or higher It may be cured at 180 ℃ or less, 170 ℃ or less, 165 ℃ or less, 160 ℃ or less, 150 ℃ or less, 140 ℃ or less, 130 ℃ or less, 120 ℃ or less, or 110 ℃ or less, but filling the implantable implant The composition is not limited to the above range as long as it is a temperature for efficiently curing in consideration of time and cost in order to prepare an implant having an appropriate hardness.

In addition, specifically, the curing may be for 1 to 10 hours, more specifically 1 hour or more, 1.5 hours or more, 2 hours or more, 2.5 hours or more, 3 hours or more, 3.5 hours or more, 4 hours or more, curing for at least 4.5 hours, at least 5 hours, at least 5.5 hours, at least 6 hours, at least 6.5 hours, at least 7 hours, at least 7.5 hours, at least 8 hours, at least 8.5 hours, at least 9 hours, or at least 9.5 hours; 10 hours or less, 9.5 hours or less, 9 hours or less, 8.5 hours or less, 8 hours or less, 7.5 hours or less, 7 hours or less, 6.5 hours or less, 6 hours or less, 5.5 hours or less, 5 hours or less, 4.5 hours or less, 4 hours or less It may be cured for less than or equal to 3.5 hours, less than 3 hours, less than 2.5 hours, less than 2 hours, or less than 1.5 hours. It is not limited to the above range if it is a time for efficiently curing in consideration.

In one aspect of the present invention, the implant for insertion into the body may be a silicone implant. In one example, the silicone implant may be an artificial breast implant.

In another aspect, the present invention provides an implant for insertion into the body filled with the composition for filling the implant for insertion into the body. The description of the composition for filling the implant for insertion into the body is the same as described above.

In one aspect of the present invention, the composition may be used to detect whether the implant for insertion into the body is ruptured. Accordingly, in another aspect, the present invention may provide a method for detecting whether or not the implant for insertion into the body is ruptured using the implant for insertion into the body filled with the above-described composition for filling. In this case, the method for detecting whether the implant for implantation into the body is ruptured may include observing the shape of the composition for filling in the implant, for example, observing the shape of the implant in the body through an X-ray image.

In detail, the rupture detection means detecting rupture, tearing, cracking, etc. of the implant inserted into the body. For example, X-ray imaging is preferable.

That is, if MRI or CT is used to detect whether or not the implant is ruptured in the body, it is possible to check whether the implant is ruptured even without using the filling composition according to an aspect of the present invention, but as is well known, MRI or CT Filming is expensive and time consuming. Therefore, there is a need for a means for easily detecting whether or not the implant for insertion into the body is ruptured in a method that can be easily photographed in a low cost and fast time, such as X-ray imaging. Since it includes a metal-organic skeleton having a metal that can be easily identified by shunyeong, etc., it is particularly useful for detecting whether the implant for implantation is ruptured or not.

In the implant for insertion into the body, the gel contained in the implant may leak into the body, and when it is leaked, it easily penetrates into surrounding tissues and causes edema. requires careful observation. According to an embodiment of the present invention, the composition for filling the implant for implantation into the body, including the metal-organic framework and the gel, includes, for example, the composition for filling the implant (ie, filling) in the implant when photographing using the aforementioned X-ray. gel) can be clearly observed, and when the implant is ruptured in the body, the rupture of the implant can be easily detected by checking, for example, leakage of the filling composition to the outside of the implant. It was confirmed that side effects can be prevented (eg, Experimental Example and FIG. 2).

In another aspect, the present invention provides a method comprising the steps of: (1) preparing a filler comprising silicon and a metal-organic framework (MOF); and (2) mixing the gel with the filler of step (1). Descriptions of the silicone, the metal-organic framework, the gel, and the implant are the same as described above.

In one example, the method for manufacturing the insert in the body may include (1) mixing and curing silicone and a metal-organic framework (MOF) to prepare a filler. At this time, as described above, a small amount of the curing agent may be used if necessary.

The metal-organic framework in the (1) preparation step for filling may be included in an amount of 1 to 40% by weight, specifically 2 to 20% by weight, based on the total weight of the silicone, gel, and the metal-organic framework. and more specifically 1 wt% or more, 1.5 wt% or more, 2 wt% or more, 2.5 wt% or more, 3 wt% or more, 3.5 wt% or more, 4 wt% or more, 4.5 wt% or more, 5 wt% or more, 6% or more, 7% or more, 8% or more, 9% or more, 10% or more, 11% or more, 12% or more, 13% or more, 14% or more, 15% or more, 16% or more, 17% or more, 18% or more, 19% or more, 20% or more, 21% or more, 22% or more, 23% or more, 24% or more, 25% or more, 26 wt% or more, 27 wt% or more, 28 wt% or more, 29 wt% or more, 30 wt% or more, 35 wt% or more, or 40 wt% or more, and 40 wt% or less, 35 wt% or less, 30 wt% or more % or less, 29% or less, 28% or less, 27% or less, 26% or less, 25% or less, 24% or less, 23% or less, 22% or less, 21% or less, 20% or less % or less, 19 wt% or less, 18 wt% or less, 17 wt% or less, 16 wt% or less, 15 wt% or less, 14 wt% or less, 13 wt% or less, 12 wt% or less, 11 wt% or less, 10 wt% or less % or less, 9 wt% or less, 8 wt% or less, 7 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, 3 wt% or less, or 2 wt% or less The content of the metal-organic framework, which is the active ingredient of the composition filled in the implant, is not limited to the above range as long as stability and safety are ensured and the content can be used for detecting whether or not the implant is ruptured.

The step (1) preparing the filler may include curing the mixture of the silicon and the metal-organic framework at 100 to 230° C. for 1 to 10 hours. The curing temperature and time may vary depending on the types of silicone and metal-organic frameworks to be cured. In addition, it may vary depending on whether or not a curing agent is used and the type.

Specifically, the (1) filler manufacturing step may include curing the mixture of the silicone and the metal-organic framework at 100 to 230 °C, more specifically 100 °C or higher, 110 °C or higher, 120 °C or higher, 130 °C or higher, 140 °C or higher, 150 °C or higher, 160 °C or higher, 165 °C or higher, 170 °C or higher, 180 °C or higher, 190 °C or higher, 200 °C or higher, 210 °C or higher, or 220 °C or higher 230 °C or lower, 220 °C or lower, 210 °C or lower, 200 °C or lower, 190 °C or lower, 180 °C or lower, 170 °C or lower, 165 °C or lower, 160 °C or lower, 150 °C or lower, 140 °C or lower, 130 °C or lower, It may include curing at 120 ° C. or less or 110 ° C. or less, but as a composition to be filled in implants for insertion into the body, in order to prepare an implant having an appropriate hardness, the temperature for curing efficiently in consideration of time and cost is in the above range not limited

In addition, specifically, the (1) filling material manufacturing step may include curing the mixture of the silicone and the metal-organic framework for 1 to 10 hours, and more specifically, 1 hour or more, 1.5 hours or more, 2 hours or more. or more, 2.5 hours or more, 3 hours or more, 3.5 hours or more, 4 hours or more, 4.5 hours or more, 5 hours or more, 5.5 hours or more, 6 hours or more, 6.5 hours or more, 7 hours or more, 7.5 hours or more, 8 hours or more, 8.5 hours or more, 9 hours or more, or 9.5 hours or more, 10 hours or less, 9.5 hours or less, 9 hours or less, 8.5 hours or less, 8 hours or less, 7.5 hours or less, 7 hours or less, 6.5 hours or less or less, 6 hours or less, 5.5 hours or less, 5 hours or less, 4.5 hours or less, 4 hours or less, 3.5 hours or less, 3 hours or less, 2.5 hours or less, 2 hours or less, or 1.5 hours or less, As a composition to be filled in the implant for insertion into the body, it is not limited to the above range as long as it is time for efficient curing in consideration of time and cost in order to manufacture an implant having an appropriate hardness.

In one aspect of the present invention, the method for manufacturing the insert into the body may include (2) mixing the gel with the filler of step (1).

In the (2) mixing step, the gel may have cohesive force, and specifically may be a cohesive gel.

Hereinafter, the configuration and effect of the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the following examples and experimental examples are provided only for the purpose of illustration to help the understanding of the present invention, and the scope and scope of the present invention are not limited thereto.

[ Example 1] metal-organic as a skeleton MOF-808 Manufacturing

The following process was performed to prepare MOF-808 as a metal-organic framework (MOF) included as an active ingredient of a composition for filling implants for implantation in the body.

Specifically, in a 50 mL glass vial, 0.485 g (1.5 mmol) of ZrOCl 8H ₂ O as a metal part was dissolved in 11.25 mL of N,N'-dimethylformamide (DMF), and then 22.5 mL of formic acid was further added. mixed. Here, after mixing 11.25 mL of DMF solution in which 0.105 g (0.5 mmol) of trimesic acid is mixed, it was reacted at 130° C. for 2 days. Thereafter, after washing with distilled water and acetone, it was transferred to distilled water and freeze-dried to prepare MOF-808.

[ Example 2] Implants for insertion into the body for filling composition preparation

The following process was performed to prepare an internal filler for filling the implantable implant.

First, 15 g of polydimethylsiloxane (PDMS) and MOF-808, which are silicone elastomers, were added in 2 wt% (0.4 g), 5 wt% ( 1 g), 10 wt % (2 g), 20 wt % (4 g).

Curing was then carried out at 165° C. and 3.5 hours. Then, a cohesive cohesive gel was mixed with the mixture of PDMS and MOF-808 to prepare a composition for filling implants for implantation into the body. At this time, as a control, a composition in which the PDMS and the cohesive gel were mixed except for MOF-808 was used.

[ Experimental example ] implant for filling the composition filled Confirmation of the effect of detecting whether the implant is ruptured when implanted into the body

In order to confirm whether or not the rupture of the implant can be detected when the implant filled with the composition for filling the implant is implanted in the body, the composition for filling the implant for insertion into the body prepared in Example 2 and the control group, respectively, were used in rats. A silicone implant having a size sufficient to be implanted in the spleen was fabricated (hereinafter referred to as an experimental group implant and a control implant, respectively), and implanted in an animal. The animals were purchased from Orient Bio (Seongnam, Gyeonggi, Korea) as SD rats (SD rats, Sprague rats), and breeding and experiments were conducted at the Seoul National University Bundang Hospital Preclinical Experiment Center (Seongnam, Gyeonggi, Korea). Animal experiments were conducted according to the rules of IACUC.

For implant implantation, SD mice were euthanized by CO ₂ , and the back area was incised by about 2 cm. Then, a pocket was made inside the incision site, into which the implant could be inserted, and each of the experimental group implant and the control implant was put into the left and right sides of the back of the SD rat. Then, X-rays were taken using Surgical mobile C-arms (Siemens, Germany), and each implant was ruptured and photographed once more, and the composition containing 20 wt% of MOF-808 was filled. The X-ray image in which the implant is implanted is shown in FIG. 2 .

As shown in FIG. 2 , in the case of an implant filled with a composition containing 20 wt% MOF-808 compared to the control group after implantation as well as after rupture, the composition for filling in the implant in vivo (i.e., gel for filling) shape was clearly observed.

When the gel leaks into the body, it is easy to penetrate into the surrounding tissues and cause edema, so it is necessary to carefully observe whether the implant is damaged when surgery, for example, breast augmentation, is performed. Therefore, it is known that the composition for filling implants for implantation into the body comprising the metal-organic framework and the gel according to an embodiment of the present invention is useful for preventing side effects due to the rupture of the implant by making it easy to observe the rupture of the implant. could

Claims (16)

A composition for filling implants for insertion into the body, comprising:
The composition comprises a metal-organic framework (MOF) and a gel,
The composition is for detecting whether the implant for insertion into the body is ruptured,
The implant for insertion into the body is an artificial breast implant,
The metal-organic framework is MOF-808 (Zr ₆ O ₄ (OH) ₄ (BTC) ₂ (HCOO) ₆ ), a composition for filling implants in the body.
delete delete delete According to claim 1,
The gel has a cohesive force, the filling composition.
According to claim 1,
The composition further comprises a silicone, a filling composition.
7. The method of claim 6,
The metal-organic framework is contained in an amount of 1 to 40% by weight based on the total weight of the silicone, gel, and the metal-organic framework.
7. The method of claim 6,
The silicone is a silicone elastomer (silicone elastomer), the filling composition.
9. The method of claim 8,
The silicone elastomer is polysilicon-11, polymethylsilsesquioxane, dimethicone crosspolymer, dimethicone / vinyl dimethicone crosspolymer, dimethicone / PEG-10/15 Crosspolymer (Dimethicone/PEG-10/15 Crosspolymer), Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Lauryl Dimethicone Crosspolymer , Dimethicone/Polyglycerin-3 Crosspolymer, Vinyl Dimethicone/Lauryl Dimethicone Crosspolymer, Diphenyldimethicone/Vinyldiphenyldimethicone/Sil A filling composition comprising at least one selected from the group consisting of diphenyl dimethicone/vinyl diphenyl dimethicone/silsesquioxane crosspolymer, and polydimethylsiloxane.
7. The method of claim 6,
The composition is a cured one, the composition for filling.
delete [Claim 11] The implantable implant filled with the composition for filling of any one of claims 1 and 5 to 10.
13. The method of claim 12,
The implant for insertion into the body is a silicone implant.
13. The method of claim 12,
The implantable implant is an artificial breast implant.
(1) preparing a filler comprising silicon and a metal-organic framework (MOF); and
(2) mixing the gel with the filler of step (1); comprising, the method of any one of claims 1 and 5 to 10 for the filling composition.
16. The method of claim 15,
In step (1), silicone and a metal-organic framework (MOF) are mixed and cured to prepare a filler, and the curing is cured at 100 to 230 ° C. for 1 to 10 hours. , a method for preparing a composition for filling.

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