KR102419592B1 - Sensitivity-adjustable absorption detection devices of liquid sample analysis and automatic measurement apparatus having thereof - Google Patents

Abstract

An absorbance detection apparatus according to one embodiment of the present invention comprises: a detection container having an accommodation space which accommodates a sample or a reaction product and through which light passes; a light source installed on the detection container and emits light to the accommodation space; a detector installed on the detection container and detects the light passing through the accommodation space; and a pump moving the sample or the reaction product to the detection container. A length of an optical path volume can be controlled by adjusting a volume of the sample or the reaction product accommodated in the accommodation space by using the pump. The absorbance detection apparatus accurately and precisely analyzes substances of interest in a wide concentration range by adjusting the length of the optical path.

Description

Absorption detection device capable of adjusting the sensitivity of liquid sample analysis, and automatic measurement device including the same

The present invention relates to an absorption detection device for quantitative and qualitative analysis of a substance of interest in a liquid sample and an automatic measurement device including the same.

Absorbance spectrophotometry is a representative optical analysis method that quantifies the degree of absorption in light of a wavelength corresponding to the complementary color of a substance of interest in a liquid sample or a product by a chemical reaction. According to Beer's law, absorbance is proportional to the optical path length. Therefore, in order to accurately and precisely analyze a substance of interest in a wide concentration range, an absorption detection device capable of adjusting the optical path length is required.

Based on the technical background as described above, the present invention provides an absorption detection device capable of adjusting the sensitivity of liquid sample analysis capable of accurately and precisely analyzing a substance of interest in a wide concentration range by adjusting the optical path length.

A light absorption detection device according to an embodiment of the present invention includes a detection vessel accommodating a sample or a reaction product and having an accommodating space through which light passes, a light source installed in the detection vessel and irradiating light into the accommodating space, and the detection vessel It is installed and includes a detector for detecting light passing through the receiving space, a pump for moving the sample or reaction product to the detection container, and adjusting the volume of the sample or reaction product accommodated in the receiving space using the pump You can control the length with

A solution detection sensor capable of detecting a sample or reaction product accommodated in the accommodation space may be installed in the detection container according to an embodiment of the present invention.

A plurality of outlets for discharging a sample or a reaction product are formed in the detection vessel according to an embodiment of the present invention, and the outlets may be spaced apart from each other in the longitudinal direction of the detection vessel.

A valve connecting the outlet and the accommodation space may be installed in the outlet according to an embodiment of the present invention.

A weight sensor for measuring the weight of a sample or reaction product may be installed in the detection vessel according to an embodiment of the present invention.

An automatic measurement device according to an embodiment of the present invention includes a manifold including a plurality of inlets for introducing a reagent and a valve installed at the inlets to control the movement of the reagent, a sample or reaction supplied from the manifold and an absorption detection device for accommodating a product and detecting a substance of interest, wherein the absorption detection device includes a detection container accommodating a sample or a reaction product and having an accommodation space through which light passes, and is installed in the detection container and enters the accommodation space A light source for irradiating light, a detector installed in the detection container to detect light passing through the accommodation space, and a pump for moving a sample or reaction product to the detection container, the pump being accommodated in the accommodation space using the pump The length of the light path can be controlled by adjusting the volume of the sample or reaction product.

A solution detection sensor capable of detecting a sample or reaction product accommodated in the accommodation space may be installed in the detection container according to an embodiment of the present invention.

A plurality of outlets for discharging a sample or a reaction product are formed in the detection vessel according to an embodiment of the present invention, and the outlets may be spaced apart from each other in the longitudinal direction of the detection vessel.

A valve connecting the outlet and the accommodation space may be installed in the outlet according to an embodiment of the present invention.

A weight sensor for measuring the weight of a sample or reaction product may be installed in the detection vessel according to an embodiment of the present invention.

A first flow path connecting the manifold and the detection vessel according to an embodiment of the present invention, a second flow path connected to the first flow path to discharge liquid from the reactor, and the second flow path are connected to the first flow path A first discharge flow path through which the washing solution washing the flow path is discharged, a second discharge flow path through which the sample remaining in the first flow path is discharged, and a main discharge flow path connected to the first flow path and discharging detected samples and reagents are provided. Further comprising, the pump may be connected to the first flow path.

A reactor that receives a reagent and a sample according to an embodiment of the present invention and mixes the reagent and sample to generate a reaction product, a first flow path connecting the manifold and the reactor, and a first flow path connecting the first flow path and completing the reaction It further includes a main discharge passage for discharging the reaction product, the detection vessel may be installed connected to the main discharge passage.

The reactor according to an embodiment of the present invention may include a reaction vessel for accommodating a sample and a reagent, an induction coil for forming a magnetic field in the reaction vessel, and a heating unit heated by a current induced by the induction coil. .

The reactor according to an embodiment of the present invention includes a heating reactor in which a sample is stored and including a heater for heating the sample, a gas absorption reactor for accommodating the gas generated in the heating reactor in a liquid state, and the heating reactor and the a connector for connecting a gas absorption reactor, wherein a connection passage connecting the heating reactor and the gas absorption reactor is formed in the connector, the gas absorption reactor is connected to the connection passage and gas permeability through which gas passes tube may be included.

As described above, the absorption detection device according to an aspect of the present invention can adjust the absorption detection sensitivity by adjusting the movement distance of the sample or reaction product in the detection cell.

In addition, it is possible to accurately and precisely analyze a substance of interest in a wide concentration range with a single light source and detector without replacing a plurality of detection cells with different optical path lengths.

In addition, it is possible to adjust the absorption detection sensitivity without moving the light source, the detector, and the detection cell.

In addition, when a plurality of outlets for discharging a sample or a reaction product are disposed to be spaced apart from each other in the longitudinal direction of the reaction vessel, and a valve is installed at each outlet, the length of the light path can be easily adjusted by using the valve.

1 is a view showing an automatic measuring device according to a first embodiment of the present invention.
2 is a view showing an automatic measuring device according to a second embodiment of the present invention.
3 is a view showing an automatic measurement device according to a third embodiment of the present invention.
4 is a view showing a reaction vessel according to a third embodiment of the present invention.
5 is a view showing an automatic measurement device according to a fourth embodiment of the present invention.
6 is a view showing an automatic measuring device according to a fifth embodiment of the present invention.
7 is a view showing an automatic measuring device according to a sixth embodiment of the present invention.
8 is a view showing a reaction vessel according to a sixth embodiment of the present invention.
9 is a view showing an automatic measurement device according to a seventh embodiment of the present invention.
10 is a view showing a reaction vessel according to a seventh embodiment of the present invention.
11 is a view showing an automatic measuring device according to an eighth embodiment of the present invention.

Since the present invention can apply various transformations and can have various embodiments, specific embodiments are illustrated and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, and should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention.

The terms used in the present invention are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise. In the present invention, terms such as 'comprising' or 'having' are intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, and one or more other features It should be understood that this does not preclude the existence or addition of numbers, steps, operations, components, parts, or combinations thereof.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In this case, it should be noted that in the accompanying drawings, the same components are denoted by the same reference numerals as much as possible. In addition, detailed descriptions of well-known functions and configurations that may obscure the gist of the present invention will be omitted. For the same reason, some components are exaggerated, omitted, or schematically illustrated in the accompanying drawings.

Hereinafter, a reactor for analyzing a liquid sample and an automatic measuring device including the same according to an embodiment of the present invention will be described.

1 is a view showing an automatic measuring device according to a first embodiment of the present invention.

Referring to FIG. 1 , the automatic measurement device 101 according to the present embodiment is a device for detecting a substance of interest included in a liquid sample. The automatic measurement device 101 may include a manifold 110 , a first flow path 141 , and a light absorption detection device 130 . In addition, the absorption detection device 130 may include a detection container 131 , a light source 137 , a detector 138 , and a pump 139 .

The manifold 110 controls the flow of fluids such as reagents, cleaning solutions, air, and samples. A plurality of inlets 113 for introducing a reagent are installed in the manifold 110 , and a solenoid valve 114 for controlling the movement of the reagent may be installed at each inlet 113 . An internal passage 112 extending in a straight line is formed in the manifold 110 , and a plurality of inlets 113 are connected to the internal passage 112 .

The manifold 110 may be formed with an air inlet through which air is introduced, a cleaning agent inlet through which a washing solution is introduced, a reagent inlet through which a reagent is introduced, and a sample inlet through which a sample is introduced. A solenoid valve 114 is installed at each inlet, and the inflow amount of the reagent may be controlled by the opening time of the solenoid valve 114 . The opening time of the solenoid valve 114 can be adjusted as short as several tens of milliseconds, and thus the flow rate of the reagent can be controlled remarkably precisely compared to the related art.

Air may be introduced through the air inlet by the pump 139 , and a negative pressure may be formed by the pump 139 , and air may be sucked into the manifold 110 through this. The introduced air may push the reagent and the sample into the detection vessel 131 . Accordingly, the supply amount of the reagent and the sample can be controlled by air.

When the portion connected to the first flow path 141 is referred to as the front, the air inlet 113 may be located at the rearmost part of the manifold 110 . Accordingly, after the reagents and samples are supplied, all of the reagents and samples remaining in the first flow path 141 may be pushed out using air.

The first flow path 141 is formed of a tube connecting the manifold 110 and the reactor 130 , and delivers reagents and samples to the detection vessel 131 . The first flow path 141 may be coupled to the lower portion of the detection vessel 131 to introduce and discharge a sample and a reagent into the detection vessel 131 . The pump 139 is connected to the first flow path 141 to move reagents and samples, and may be a bidirectional pump. The first flow path 141 may be connected to a main discharge flow path 143 for discharging the sample and reagent for which measurement has been completed.

The detection vessel 131 accommodates a sample or a reaction product and has an accommodation space 132 through which light passes. A sample or a reaction product is introduced into the receiving space 132 , and the reaction product may be a liquid in which a sample and a reagent are mixed.

In the case of a colored sample without a reagent, it may flow into the receiving space without mixing with the reagent. The receiving space 132 is formed extending in the longitudinal direction of the detection vessel 131 , and an inlet 133 through which a reagent or a reaction product is introduced may be formed on the side of the receiving space 132 .

Windows (181, 182) for preventing leakage of fluid may be installed at the upper end and lower end of the receiving space (132). The windows 181 and 182 are made of a material having a light transmittance, and may be made of a lens or a slit may be formed.

The light source 137 is installed at one end of the detection vessel 131 in the longitudinal direction and irradiates light. On the other hand, the detector 138 is installed at the other end of the longitudinal direction of the detection vessel 131 and detects light. The light source 137 may be coupled to the upper portion of the detection vessel 131 , and the detector 138 may be coupled to the lower portion of the detection vessel 131 , but the present invention is not limited thereto.

The light irradiated by the light source 137 passes through the receiving space 132 and flows into the detector 138 . In this process, some of the light is absorbed by a reagent, etc., and the remaining light flows into the detector 138 , so the absorbance It is possible to measure the concentration of the substance of interest through

The first flow path 141 is connected to the inlet 133 , and a sample or a reaction product may be introduced and discharged through the inlet 133 . The pump 139 controls the flow rate of the sample or reaction product flowing into the first flow path 141 , and the flow rate and movement time of the sample are controlled by the pump 139 .

Accordingly, the volume of the sample or reaction product stored in the receiving space 132 is easily controlled. The height at which the sample or reaction product stored in the accommodating space 132 is accommodated is the length of the optical path through which light passes. According to the present embodiment, since the optical path length is easily controlled by adjusting the volume, a wide range of concentrations can be measured.

Conventionally, when a sample having a different detection range is detected, a plurality of detection cells and detection cell holders having different optical path lengths are used, or in the case of an automatic measuring device for on-site use, a plurality of absorption detection devices are required. Also, conventionally, the light path length is adjusted by moving the light source, the detector, or the detection cell, but in this case, a separate device for moving the light source, the detector, and the like is required.

However, according to the present embodiment, since the volume of the sample stored in the detection container 131 is controlled by the pump 139, the optical path length can be easily controlled without moving the light source or the detector.

Hereinafter, an automatic measurement device according to a second embodiment of the present invention will be described.

2 is a view showing an automatic measuring device according to a second embodiment of the present invention.

Referring to FIG. 2 , since the automatic measurement device 102 according to the present embodiment has the same structure as the first embodiment except for the solution detection sensor 136 , a redundant description of the same configuration will be omitted. do.

A solution detection sensor 136 capable of detecting a sample or a reaction product is installed in the detection vessel 131 , and the plurality of solution detection sensors 136 may be longitudinally spaced apart from the detection vessel 131 . The solution detection sensor 136 may be formed of an electrode type sensor, an optical sensor, a capacitive sensor, or the like. When the solution detection sensor 136 is installed in the detection container 131 as described above, the height of the sample accommodated in the detection container 131 can be easily determined.

Hereinafter, an automatic measurement device according to a third embodiment of the present invention will be described.

3 is a view showing an automatic measuring device according to a third embodiment of the present invention, and FIG. 4 is a view showing a reaction vessel according to a third embodiment of the present invention.

3 and 4, since the automatic measurement device 103 according to the present embodiment has the same structure as the first embodiment except for the detection vessel 131 and the control valve 185, A duplicate description of the same configuration will be omitted.

The detection vessel 131 accommodates a sample or a reaction product and has an accommodation space 132 through which light passes. The receiving space 132 is formed extending in the longitudinal direction of the detection vessel, and an inlet 133 through which a sample or a reaction product is introduced may be formed next to the receiving space 132 . The detection container 131 may be installed upright, and as shown in FIG. 3 , the lengthwise direction of the accommodation space 132 may be disposed to lie parallel to the ground. When the longitudinal direction of the accommodating space 132 is parallel to the ground, the cross-sectional area of the accommodating space 132 is sufficiently small, so that an empty space is not formed in the height direction of the accommodating space 132 .

In addition, a plurality of outlets 134 for discharging the sample or reaction product are formed in the detection vessel 131 , and the outlets 134 are spaced apart from each other in the longitudinal direction of the detection vessel. Also, a control valve 185 for controlling the connection between the outlet 134 and the accommodation space 132 is installed at each outlet 134 .

Accordingly, when the control valve 185 adjacent to the inlet 133 and the receiving space 132 are connected, an excessively introduced sample, etc. is discharged through the outlet 134 adjacent to the inlet, so that a light path of a small length can be easily formed. have. On the other hand, when the control valve 185 and the reaction space disposed far from the inlet 133 are connected, and the remaining control valves 185 are closed, the excess sample is discharged through the outlet 134 disposed farthest from the inlet. A long-length optical path can be easily formed.

As such, when the plurality of outlets 134 and the plurality of control valves 185 are installed in the detection vessel 131 , the length of the portion filled with the sample or reaction product in the horizontally connected accommodation space 132 can be controlled. Since the length of the portion filled with the sample or reaction product becomes the optical path length, the optical path length can be easily controlled to accurately and precisely measure a substance of interest in a wide concentration range.

Hereinafter, an automatic measurement device according to a fourth embodiment of the present invention will be described.

5 is a view showing an automatic measurement device according to a fourth embodiment of the present invention.

Referring to FIG. 5 , the automatic measurement device 104 according to the present embodiment includes a manifold 110 , a first flow path 141 , a sample flow path 145 , a second flow path 142 , and a main discharge flow path ( 143 ), a first discharge flow path 146 , a second discharge flow path 147 , and a light absorption detection device 130 . In addition, the absorption detection device 130 may include a detection container 131 , a light source, a detector, and a pump 139 .

The automatic measuring device 104 according to the present embodiment has a sample flow path 145 , a second flow path 142 , a main discharge flow path 143 , a first discharge flow path 146 , and a second discharge flow path 147 . Since has the same structure as the above-described first embodiment, redundant description of the same configuration will be omitted.

The manifold 110 controls the movement of reagents, washing solutions, air, and the like. The first flow path 141 is formed of a tube connecting the manifold 110 and the detection vessel 130 , and delivers reagents and samples to the detection vessel. The first flow path 141 may be coupled to the lower portion of the detection vessel 131 to introduce and discharge a sample and a reagent into the detection vessel 131 .

The sample flow path 145 is installed to be connected to the first flow path 141 , and is connected to the first flow path 141 between the pump 139 and the manifold 110 . The sample flow path 145 is connected to the first flow path 141 via the three-way valve 151 and transfers the sample in a liquid state to the first flow path 141 . The sample flow path 145 may be connected to the water tank 900 in which the sample is stored to supply the sample.

The second flow path 142 is connected to the detection vessel 131 to discharge the liquid from the detection vessel 131 . The second flow path 142 may be directly connected to the reactor or may be connected to the reactor via the first flow path 141 . In this embodiment, the second flow path 142 may be connected to the first flow path 141 via the three-way valve 152 , and the surplus field sample and the washing solution flow through the second flow path 142 by the pump 139 . can move along.

A first discharge flow path 146 and a second discharge flow path 147 are connected to the second flow path 142 , and the first discharge flow path 146 and the second discharge flow path 147 are connected via a three-way valve 153 . may be connected to the second flow path 142 . The washing liquid washing the first flow path 141 may be discharged through the first discharge flow path 146 .

After the sample and reagent are supplied to the detection vessel 131, a washing solution is supplied to the first flow path 141 during the reaction to wash the first flow path 141, and then the second flow path 142 and the second flow path 141 1 may be discharged through the discharge passage 146 .

The second discharge flow path 147 is connected to the second flow path 142 through the three-way valve 153 , and the sample remaining in the first flow path 141 is to be discharged through the second discharge flow path 147 . can After the sample is supplied to the detection vessel 131 , air may be supplied to the first flow path 141 through the manifold 110 , and the sample remaining in the first flow path 141 is pushed out by the air to the second flow path 141 . It may be discharged to the outside through the flow path 142 and the second discharge flow path 147 . Accordingly, since the on-site sample is not discharged together with the washing solution or the material after the reaction, the generation of waste solution can be minimized.

Meanwhile, the first flow path 141 may be connected to a main discharge flow path 143 for discharging the detected sample and reagent. The main discharge flow path 143 may be coupled to the first flow path 141 between a portion where the sample flow path 145 and the first flow path 141 are connected and the pump 139 . The main discharge flow path 143 may be connected to the first flow path 141 via a three-way valve 154 .

When the main discharge passage 143 through which the waste liquid, which is a material after the reaction, is discharged is separately installed, the waste liquid is not mixed with the washing liquid and the sample, so that the generation of the waste liquid can be minimized. In addition, when the main discharge flow path 143 is connected to the first flow path 141 between the pump 139 and the sample flow path 145 , when the pump 139 moves the liquid toward the main discharge flow path 143 , detection Since the inside of the container 131 is in a negative pressure state, it is possible to reliably remove the material after the reaction inside the detection container 131 .

Hereinafter, an automatic measurement device according to a fifth embodiment of the present invention will be described.

6 is a view showing an automatic measuring device according to a fifth embodiment of the present invention.

Referring to FIG. 6 , in the automatic measurement device 105 according to the present embodiment, the detection vessel 131 is installed in the main discharge flow path 143 , and the reactor 230 is connected to the first flow path 141 . .

The reactor 230 may receive a reagent and a sample and mix the reagent and the sample to generate a reaction product. The reactor 230 may include a heater for heating and a fan for cooling, and the heater may be heated in a manner such as electric resistance heating or induction heating.

The first flow path 141 is connected to a main discharge flow path 143 through which the reaction product moves. The detection vessel 131 is connected to the main discharge passage 143 and installed, and the reaction product of the sample and the reagent reacted in the reactor 130 passes through the first passage 141 and the main discharge passage 143 to the detection vessel 131 . ), and the reaction product moved to the detection vessel 131 is accommodated in the detection vessel 131 so that the component can be detected.

Hereinafter, an automatic measurement device according to a sixth embodiment of the present invention will be described.

7 is a view showing an automatic measuring device according to a sixth embodiment of the present invention, and FIG. 8 is a view showing a reaction vessel according to a sixth embodiment of the present invention.

7 and 8, the automatic measurement device 106 according to the present embodiment has the same structure as the automatic measurement device according to the fifth embodiment, except for the reactor 230, and thus has the same configuration. A duplicate description will be omitted.

The reactor 230 receives reagents and samples, and the reagents and samples may be mixed in the reactor 230 . The air introduced into the reactor 230 through the pump 139 may mix reagents and samples.

The reactor 230 includes a reaction vessel 231 , an induction coil 232 , a heating unit 234 , a temperature sensor 235 , a cooling fan 236 , a first pressure valve 238 , and a second pressure valve 239 . ) may be included. The reactor 230 may convert a substance of interest into a form capable of analysis by heating the sample and reagent.

The reaction vessel 231 has a tube shape for accommodating a sample and a reagent, and may be made of heat-resistant glass having light transmittance. However, the present invention is not limited thereto, and the reaction vessel 231 may be made of metal. When the reaction vessel 231 is made of metal, the reaction vessel 231 may be heated together with the heating unit 234 by an induction coil.

A gas outlet through which gas is discharged may be formed at an upper portion of the reaction vessel 231 , and a solution outlet through which a solution is introduced and discharged may be formed at a lower portion of the reaction vessel 231 .

The first pressure valve 238 may be coupled to the lower end of the reaction vessel 231 , and the second pressure valve 239 may be coupled to the upper end of the reaction vessel 231 . The first pressure valve 238 and the second pressure valve 239 may be formed of a ball valve capable of supporting a high pressure.

The first pressure valve 238 is disposed as close to the reaction vessel as possible at the lower end of the reaction vessel 231, and accordingly, when the pressure inside the reaction vessel 231 increases, it is possible to prevent the reaction solution from flowing out. .

The induction coil 232 is spirally wound around the reaction vessel 231 , and forms a magnetic field inside the reaction vessel 231 . The induction coil 232 is wound around the vessel at intervals in the height direction of the reaction vessel 231 , and accordingly, the outer peripheral surface of the reaction vessel 231 is exposed between the induction coils. A high-frequency oscillator for generating a high-frequency current may be connected to the induction coil. Although the present embodiment illustrates that the reactor 230 is heated by the induction coil 232 , the present invention is not limited thereto, and the reactor 230 may be heated in various ways.

The heating unit 234 is inserted and installed in the reaction vessel 231 and is formed in a bar shape extending in the height direction of the reaction vessel 231 . A support 233a protruding downward to support the heating unit 234 may be formed on the upper stopper 233 . The heating unit 234 may be made of a metal rod and be fixed to the upper portion of the reaction vessel 231 . The heating unit 234 may be made of a nickel alloy having corrosion resistance.

The heating unit 234 is heated by the induction coil 232 , and the magnetic field generated by the induction coil 232 may form an eddy current in the heating unit 234 , so that the heating unit 234 may be heated.

Bubbles may be formed on the surface of the heating unit 234 by induction heating, and a dolby phenomenon in which the reaction solution rapidly boils due to the generation of bubbles may be prevented.

The temperature sensor 235 may be a non-contact temperature sensor that is spaced apart from the reaction vessel 231 to measure the temperature of the reaction vessel 231 , and may be an infrared temperature sensor. The cooling fan 236 is installed on a support and is spaced apart from the reaction vessel 231 to supply air toward the reaction vessel 231 . Accordingly, the reaction vessel 231 exposed to the outside can be rapidly cooled by being in direct contact with the air.

Hereinafter, an automatic measuring device according to a seventh embodiment of the present invention will be described.

9 is a view showing an automatic measuring device according to a seventh embodiment of the present invention, and FIG. 10 is a view showing a reaction vessel according to a seventh embodiment of the present invention.

9 and 10, the automatic measuring device 107 according to the present embodiment has the same structure as the automatic measuring device according to the fifth embodiment, except for the reactor 201, and thus has the same configuration. A duplicate description will be omitted.

The reactor 201 may be connected to the first flow path 141 to receive samples and reagents. The reactor 201 may include a heating reactor 210 for heating a sample, a gas absorption reactor 250 for absorbing a vaporized sample, and a connector 240 for connecting the heating reactor 210 and the gas absorption reactor 250 . can

The heating reactor 210 is connected to the first flow path 241 to receive reagents and samples from the first flow path 241 . Reagents and samples may be mixed in the heating reactor 210 . The air introduced into the heating reactor 210 through the first pump 139 may mix reagents and samples. However, the present invention is not limited thereto, and the sample and reagent may be mixed in a separate device and then introduced into the heating reactor 210 .

The heating reactor 210 may include a reaction vessel 215 in which samples and reagents are stored and a heater 211 for heating the reaction vessel 215 . In addition, the heating reactor 210 may further include a temperature sensor for temperature measurement and a cooling fan for cooling.

The heating reactor 210 may not only mix and react a sample and a reagent, but also heat the sample to convert a substance of interest into a gas. The conversion of the substance of interest in the liquid sample to a gas is possible only by heating without reaction with the reagent, and the reagent may be made of various substances. The reaction vessel 215 is formed in a tube shape for accommodating a sample and a reagent, and may be formed of heat-resistant glass having light transmittance. However, the present invention is not limited thereto, and the reaction vessel 215 may be made of metal, plastic, ceramic, or the like. A connector 240 through which gas is discharged may be connected to the upper portion of the reaction vessel 215 .

The heater 211 generates heat to heat the reaction vessel 215 , and may have various structures such as a structure including a heating wire and an induction heating structure, but the present invention is not limited to the structure of the heater. The heater 211 may be installed to heat the lower portion of the heating reactor 210 .

The connector 240 connects the heating reactor 210 and the gas absorption reactor 250 , and transfers the gas generated in the heating reactor 210 to the gas absorption reactor 250 . A connection passage 241 passing through the inside is formed in the connector 240 , and the gas generated in the heating reactor 210 may be transferred to the gas absorption reactor 250 through the connection passage 241 . The lower end of the connector 240 may be coupled to the upper end of the heating reactor 210 , and the upper end of the connector 240 may be coupled to the lower end of the gas absorption reactor 250 .

The absorption liquid passage 149 is connected to the first passage 141 to supply the absorbent liquid transferred from the first passage 141 to the gas absorption reactor 250 . The absorbent liquid may be made of various materials.

The gas absorption reactor 250 receives the gas generated in the heating reactor 210 in a liquid state. The gas absorption reactor 250 includes a reaction vessel 252 and a gas permeable tube 251 inserted into the reaction vessel 252 . A stopper 259 is installed on the upper portion of the reaction vessel 252 , the gas permeable tube 251 is installed to pass through the stopper 259 , and the stopper 259 may support the gas permeable tube 251 . The gas permeable tube 251 is inserted into and penetrates the gas absorption reactor 250, and may be made of a porous material having hydrophobicity.

Even if there is a liquid in the gas-permeable tube 251 having hydrophobicity, only the vaporized gas can selectively permeate and be absorbed by the absorbent liquid. Accordingly, it is possible to prevent a decrease in analytical sensitivity due to dilution resulting from an increase in the absorption liquid due to the condensed water vapor. The gas permeable tube 251 may be formed of a flexible tube, and may be formed in a straight line or a curved line.

A pressure regulating member 255 for regulating the pressure inside the gas absorption reactor 250 is installed in the gas permeable tube 251 . The pressure adjusting member 255 may be formed in the form of a valve. When the pressure adjusting member 255 is installed in the gas-permeable tube 251 as in the present embodiment, it is possible to adjust the gas introduced into the gas-permeable tube 251 to smoothly move into the absorption liquid.

The gas absorption reactor 250 is connected to the detection vessel 131 through the main discharge passage 143 , and the main discharge passage 143 delivers the absorption liquid in which the substance of interest has been absorbed to the detection vessel 131 . An auxiliary pump 222 for transferring the absorption liquid and the washing liquid may be installed in the main discharge passage 143 . The detection container 131 receives the absorption liquid and detects the concentration of the substance of interest contained in the absorption liquid.

Meanwhile, a first drain channel 275 for discharging the solution remaining in the heating reactor 210 may be connected to the first flow path 141 . Also, after the heating reaction is completed, a washing solution may be injected into the heating reactor 210 , and the washing solution used for washing the heating reactor 210 may be discharged through the first drain passage 275 .

A second drain passage 276 is connected to the detector 160 , and the solution used for detection and the solution used for cleaning the gas absorption reactor 230 and the detection vessel 131 pass through the second drain passage 276 . can be discharged through A fourth flow path 144 connecting the detection vessel 131 and the first flow path 141 may be installed, and the fourth flow path 144 may supply a detection reagent to the detection vessel 131 .

In addition, the first discharge flow path 146 and the second discharge flow path 147 are connected to the first flow path 141 , and the washing liquid washing the first flow path 141 is to be discharged through the first discharge flow path 146 . Also, the sample remaining in the first flow path 141 may be discharged through the second discharge flow path 147 .

Hereinafter, an automatic measuring device according to an eighth embodiment of the present invention will be described.

11 is a view showing an automatic measuring device according to an eighth embodiment of the present invention.

Referring to FIG. 11 , the automatic measuring device 108 according to the present embodiment has the same structure as that of the first embodiment except for the weight sensor 270 , and thus a redundant description of the same configuration will be omitted. .

A weight sensor 270 for measuring the weight of a sample or reaction product is installed in the detection vessel 131 , and the weight sensor 270 is installed at the lower portion of the detection vessel 131 to change the weight according to the inflow of the sample or reaction product can be measured.

The weight sensor 270 may include sensors having various structures, such as a load cell, a resonance sensor, and a capacitive sensor. When the weight sensor 270 is installed in the detection container 131 as described above, the weight of the sample accommodated in the detection container 131 can be easily grasped, and the volume can be easily derived using the weight of the sample or the like.

In the above, an embodiment of the present invention has been described, but those of ordinary skill in the art can add, change, delete or add components within the scope that does not depart from the spirit of the present invention described in the claims. It will be possible to variously modify and change the present invention by, etc., which will also be included within the scope of the present invention.

101, 102, 103, 104, 105, 106, 107, 108: automatic measuring device
110: manifold
130: absorption detection device
131: detection vessel
132: accommodation space
134: outlet
136: solution detection sensor
137: light source
138: detector
139: pump
141: 1st Euro
142: 2nd Euro
143: main discharge flow path
145: sample flow path
146: first discharge flow path
147: second discharge flow path
181, 182: window
185: control valve
201, 230: reactor
270: weight sensor

Claims (14)

a detection vessel accommodating a sample or reaction product and having an accommodating space through which light passes;
a light source installed in the detection container and irradiating light into the accommodation space;
a detector installed in the detection container and detecting the light passing through the accommodation space; and
a pump for moving the sample or reaction product to the detection vessel;
including,
Controlling the optical path length by adjusting the volume of the sample or reaction product accommodated in the receiving space using the pump,
A plurality of outlets for discharging the sample or reaction product are formed in the detection vessel, and the outlets are spaced apart from each other in the longitudinal direction of the detection vessel,
A plurality of valves for controlling the connection between the outlet and the accommodation space are installed in the detection vessel, and an optical path is controlled by the valves. According to claim 1,
The light absorption detection device, characterized in that the detection vessel is provided with a solution detection sensor capable of detecting the sample or reaction product accommodated in the receiving space. delete delete According to claim 1,
The light absorption detection device, characterized in that the detection vessel is provided with a weight sensor for measuring the weight of the sample or reaction product. a manifold including a plurality of inlets for introducing a reagent and a valve installed at the inlet to control movement of the reagent; and
an absorption detection device for receiving a sample or reaction product supplied from the manifold and detecting a substance of interest;
including,
The light absorption detection device,
a detection vessel accommodating a sample or reaction product and having an accommodating space through which light passes;
a light source installed in the detection container and irradiating light into the accommodation space;
a detector installed in the detection container and detecting the light passing through the accommodation space;
a pump for moving the reagent or sample to the detection vessel;
includes,
Controlling the optical path length by adjusting the volume of the sample or reaction product accommodated in the receiving space using the pump,
A plurality of outlets for discharging the sample or reaction product are formed in the detection vessel, and the outlets are spaced apart from each other in the longitudinal direction of the detection vessel,
A plurality of valves for controlling the connection between the outlet and the accommodation space are installed in the detection vessel, and the optical path is controlled by the valves. 7. The method of claim 6,
The automatic measurement device, characterized in that the solution detection sensor for detecting the sample or reaction product accommodated in the receiving space is installed in the detection vessel. delete delete 7. The method of claim 6,
The automatic measuring device, characterized in that the weight sensor for measuring the weight of the sample or reaction product is installed in the detection vessel. 7. The method of claim 6,
A reactor that receives a reagent and a sample and mixes a reagent and a sample to generate a reaction product, a first flow path connecting the manifold and the detection vessel, and a second flow path connected to the first flow path to discharge the liquid from the reactor and a first discharge flow path connected to the second flow path through which the washing liquid washing the first flow path is discharged, a second discharge flow path through which the sample remaining in the first flow path is discharged, and the first flow path are connected to detect detection The automatic measurement device, characterized in that it further comprises a main discharge flow path for discharging the completed sample and reagent, wherein the pump is connected to the first flow path. 7. The method of claim 6,
A reactor that receives a reagent and a sample and mixes a reagent and a sample to generate a reaction product, a first flow path connecting the manifold and the reactor, and a main discharge flow path connected to the first flow path and discharging a reaction product on which the reaction is completed The automatic measurement device further comprising, wherein the detection vessel is connected to the main discharge passage. 13. The method of claim 12,
The reactor comprises a reaction vessel for accommodating a sample and a reagent, an induction coil for forming a magnetic field in the reaction vessel, and a heating unit heated by the current induced by the induction coil. a manifold including a plurality of inlets for introducing a reagent and a valve installed at the inlet to control movement of the reagent; and
an absorption detection device for receiving a sample or reaction product supplied from the manifold and detecting a substance of interest;
a reactor that receives a reagent and a sample and mixes the reagent and the sample to generate a reaction product;
a first flow path connecting the manifold and the reactor, and a main discharge flow path connected to the first flow path and discharging a reaction product on which the reaction is completed;
including,
The light absorption detection device,
a detection vessel accommodating a sample or reaction product and having an accommodating space through which light passes;
a light source installed in the detection container and irradiating light into the accommodation space;
a detector installed in the detection container and detecting the light passing through the accommodation space;
a pump for moving the reagent or sample to the detection vessel;
includes,
Controlling the optical path length by adjusting the volume of the sample or reaction product accommodated in the receiving space using the pump,
The reactor includes a heating reactor in which a sample is stored and including a heater for heating the sample, a gas absorption reactor for accommodating the gas generated in the heating reactor in a liquid state, and a connector connecting the heating reactor and the gas absorption reactor. and a connection passage connecting the heating reactor and the gas absorption reactor is formed inside the connector, and the gas absorption reactor includes a gas permeable tube connected to the connection passage and allowing gas to pass therethrough. automatic measuring device.

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