KR102338952B1 - Pharmaceutical container for cold chain logistics - Google Patents

Abstract

Provided is a pharmaceutical transport container for cold chain logistics that can provide a constant temperature effect optimized for pharmaceutical transport. A pharmaceutical transport container for cold chain logistics includes a body part which is formed of expanded polypropylene and has an internal space defied by integrally forming a bottom wall and a plurality of side walls extending upwardly from the bottom wall; a body insulator arranged on the outer surface of the bottom wall and the outer surface of the plurality of side walls; an outer box arranged outside the body insulator; a cover part covering the top of the body part; and a refrigerant, wherein the body insulator and the refrigerant can be separated about the body part.

Description

Pharmaceutical transport container for cold chain

The present invention relates to a pharmaceutical transport container for cold chain use.

Cold chain refers to a low-temperature logistics system that covers the entire process of production, storage, distribution, and sales of temperature-sensitive products from fresh food to pharmaceuticals. A representative example of the goods that require transport by the cold chain include pharmaceuticals, such as vaccines.

Unlike general medicines such as cold medicines, digestive medicines, and analgesics, which can be delivered and transported under general distribution conditions due to their excellent stability, there are medicines that require special storage conditions for drug stability. For example, biological drugs that must be stored under low-temperature conditions, biopharmaceuticals manufactured using raw materials or materials derived from humans or other living organisms, genetically modified drugs, cell culture drugs, cell therapy products, gene therapy products, etc. According to 'EvaluatePharma', a market research institute, biopharmaceuticals are expected to occupy up to 35% of the total pharmaceutical market by 2026. As an example of biopharmaceuticals that require special storage conditions, vaccines are representative. Since vaccines are made of proteins, their antigens are made up of proteins, so when the temperature changes, the proteins are degenerated, and the effectiveness of the vaccines is reduced or there is a high possibility of causing unexpected side effects. According to the International Health Organization, about 50% of the total vaccine production worldwide is destroyed during storage and transportation and is discarded.

As such, as the types of medicines that require special storage and transportation conditions are increasing day by day, the need for containers that enable stable storage and transportation of medicines is increasing day by day. In particular, there is an increasing demand for containers that can safely deliver medicines to their final destination without damaging the insulation even when the temperature change during delivery is not large and the cryogenic temperature required for medicines is maintained in the cold chain system.

Conventional containers for transporting medicines have a problem in that they are insufficient or impossible to maintain a high level of still temperature and temperature control required for medicines with difficult storage temperature conditions. As described above, these medicines are sensitive to temperature, and there is a high risk of product deterioration during storage and transportation, and the result is directly related to human health. You need to provide an effect. In addition, in the case of pharmaceuticals with difficult storage temperature conditions, such as biologics or biopharmaceuticals, they are often delivered in glass containers such as vials and ampoules, which are fragile, unlike general delivery products, so transportation stability is required during transportation. , it is necessary that the container does not collapse when the container is loaded.

The present invention has been made by recognizing these problems and solving them, and provides a container for transporting drugs that can provide a calming effect optimized for transport of drugs. Accordingly, the present invention improves the problem of drug deterioration during transport of the drug.

In addition, the present invention provides a high thermal insulation effect from the structure of the container itself, and improves delivery stability by providing a container with a significantly reduced risk of internal damage even on a cryogenic cold chain system. In addition, since the refrigerant structure inside is stably fixed, it is improved that the refrigerant structure is tilted in one direction during transportation and a problem occurs in temperature control.

In addition, the container of the present invention has high loading stability without forming a sharp protrusion on the outside of the container, preventing injury to a person handling the container, and lowering the risk of the container collapsing, thereby ensuring handling stability.

Cold chain medicine transport container according to an embodiment of the present invention, a lower wall (bottom wall), and a plurality of side walls extending in the upper direction from the lower wall (side wall) are integrally formed to define an internal space, Body portion formed of expanded polypropylene; a body insulation material disposed on the outer surface of the lower wall and the outer surface of the plurality of side walls; an outer box disposed outside the body insulation; a cover part covering the upper part of the body part; and a refrigerant, and the body heat insulating material and the refrigerant may be separated based on the body part.

In one embodiment of the present invention, the outer box is made of plastic or paper material, and the outer box may be formed to surround the body portion, the body heat insulating material and the outer surface of the cover portion.

Cold chain medicine transport container according to an embodiment of the present invention, between the body heat insulating material and the outer box, further comprises an additional body portion formed to surround the outer surface of the body insulation material, the additional body portion may be made of polypropylene foam.

In one embodiment of the present invention, the body insulation material may be a vacuum insulation material.

In one embodiment of the present invention, the vacuum insulating material, one or more plate-shaped vacuum insulating material; Alternatively, it may be a single three-dimensional structure type vacuum insulator folded to have a lower surface and a plurality of side surfaces extending upward from the lower surface.

In one embodiment of the present invention, the thickness of the vacuum insulating material may be 3 mm to 30 mm.

In one embodiment of the present invention, the cold chain medicine transport container further includes an additional heat insulating material disposed on the outer surface or the inner surface of the body heat insulating material, and the thickness of the additional heat insulating material may be smaller than the thickness of the body heat insulating material.

In one embodiment of the present invention, the thickness of the additional insulating material may be 3 mm to 10 mm.

In one embodiment of the present invention, the thickness of the body heat insulating material disposed on the outer surface of the lower wall of the body heat insulating material may be thicker than the thickness of the body heat insulating material disposed on the outer surface of the plurality of side walls.

In one embodiment of the present invention, the cover portion may include a cap portion disposed so as to accommodate the cover insulation material therein, and cover the cover insulation material.

In one embodiment of the present invention, the cover insulating material may be a vacuum insulating material.

In one embodiment of the present invention, the thickness of the vacuum insulating material may be 3 mm to 30 mm.

In one embodiment of the present invention, the refrigerant is a plurality of phase changing material (PCM) disposed on the inner surface of the lower wall and the inner surface of the plurality of side walls, each of the plurality of PCM cross-section may have a trapezoidal shape.

In one embodiment of the present invention, the refrigerant may be located in a refrigerant box disposed in some space inside the body portion.

In one embodiment of the present invention, the refrigerant may be dry ice.

In one embodiment of the present invention, it further comprises an inner packaging box for accommodating the product, the refrigerant box is stacked on the inner packaging box, and one or more of the bottom surfaces of the refrigerant box not covered by the inner packaging box are on the bottom surface of the refrigerant box. A hole may be formed.

In one embodiment of the present invention, the width of the refrigerant box is formed to be larger than the width of the inner packing box, an additional refrigerant disposing area is defined between the inner packing box and the body portion, and dry ice is disposed in the additional refrigerant disposing area. can

In one embodiment of the present invention, it further comprises an inner packaging box for accommodating the product, and a box guide formed to surround the inner packaging box, wherein the refrigerant box is laminated on the inner packaging box and the box guide, the bottom surface of the refrigerant box One or more holes may be formed in the bottom surface not covered by the inner packing box and the box guide.

In one embodiment of the present invention, the width of the refrigerant box is formed to be larger than the width of the box guide, an additional refrigerant arrangement area is defined between the box guide and the body part, and dry ice can be disposed in the additional refrigerant arrangement area .

In one embodiment of the present invention, the medicine transport container for cold chain further comprises a box guide for fixing the inner packaging box for accommodating the product to the body portion, and the refrigerant box has an inner portion fixed to the body portion through the box guide. It may be arranged to contact the packaging box.

In one embodiment of the present invention, the medicine transport container for cold chain may further include a data logger for recording data by sensing the internal space.

According to embodiments of the present invention, the body heat insulating material is located outside the body portion in the structure of the container for transporting medicines, so that direct contact with the refrigerant located inside the body portion does not occur during transportation. Unlike the general delivery process, cryogenic PCM or dry ice is used as a refrigerant in the transport process of medicines, eg, vaccines, and the temperature of PCM at this time reaches a temperature of -20 °C to -80 °C. A vacuum insulation material that was not damaged when in contact with PCM at a normal refrigeration temperature, for example, 2 ° C to 8 ° C, has a very high risk of damage to the film when in contact with PCM or dry ice at such a cryogenic temperature, This will soon reduce the calming effect inside the container. However, the cold chain medicine transport container of the present invention can prevent such damage by adopting the arrangement structure of the body heat insulating material located outside the body part and the refrigerant located inside the body part, for example, PCM.

Accordingly, since the vacuum insulation material constituting the body insulation material does not have a risk of damage due to collision with an article or a refrigerant during transportation or storage, the material of the vacuum insulation material, particularly the material of the outer covering material, can be widely selected.

In addition, by adopting a body portion having a relatively low density characteristic and a body insulation material having a relatively high density but superior thermal insulation performance at the same time, the heat insulation performance of the medicine transport container for the cold chain is secured and weight reduction is realized at the same time. Accordingly, when using air transport, etc., transportability and cost can vary greatly depending on the weight range, and while achieving light weight suitable for air transport, the thermal insulation effect is improved compared to the conventionally used cold chain medicine transport container. A container for transporting medicines for use may be provided.

1 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
Figure 2 is a view showing the body portion and the cover portion of the cold chain medicine transport container according to an embodiment of the present invention.
3A and 3B are views showing a cover part of a medicine transport container for a cold chain according to an embodiment of the present invention.
4A and 4B are views showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
5 is a view showing the PCM of the medicine transport container for a cold chain according to an embodiment of the present invention.
6 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
7 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
8 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
Figure 9a is an exploded view showing a medicine transport container for a cold chain according to an embodiment of the present invention.
9b to 9d are views showing a medicine transport container for a cold chain according to various embodiments of the present invention.
9e to 9i are views showing embodiments of box guides usable for a cold chain medicine transport container according to various embodiments of the present invention.
10 is a view showing the corner guide portion of the cold chain medicine transport container according to an embodiment of the present invention.
11 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
12 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
13 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
14 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
15 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.
16 is an exploded view showing a medicine transport container for a cold chain according to an embodiment of the present invention.
17 and 18 are graphs for explaining the thermal insulation performance of the medicine transport container for a cold chain according to an embodiment of the present invention.
19 and 20 are graphs for explaining the thermal insulation performance of the medicine transport container for a cold chain according to an embodiment of the present invention.
21 is a graph for explaining the thermal insulation performance of the cold chain medicine transport container according to an embodiment of the present invention.
22 is a view for explaining a modification of the trapezoidal cross-sectional shape of the PCM that can be used in the cold chain medicine transport container according to an embodiment of the present invention.
23 and 24 are graphs for explaining the thermal insulation performance of the cold chain medicine transport container to which the refrigerant box is applied according to an embodiment of the present invention.
25 to 27 are graphs for explaining the thermal insulation performance of a cold chain medicine transport container when dry ice is used as a refrigerant and PCM is used according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily implement them. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein. And in order to clearly explain the present invention in the drawings, parts irrelevant to the description are omitted, and similar reference numerals are attached to similar parts throughout the specification. In addition, in order to clearly express various layers and regions in the drawings, the thicknesses are enlarged or reduced, or for convenience of explanation, the thicknesses of some layers and regions are exaggerated.

Throughout the specification and claims, when a part "includes" a certain element, it means that other elements may be further included, rather than excluding other elements, unless specifically stated to the contrary. Also, that an arbitrary component is formed or disposed on the “upper (or lower)” of the substrate or “top (or below)” of the substrate means that the optional component is formed or disposed in contact with the upper surface (or lower surface) of the substrate. It is not intended to mean, but is not limited to, the exclusion of any configuration formed or disposed on (or under) the substrate and other configurations between the substrate.

The present invention provides a medicine transport container for a cold chain for transporting products requiring constant temperature transport, for example, medicines. According to the present invention, by using the vacuum insulation panel and the expanded polypropylene in an appropriate ratio, it is possible to control the temperature and to prevent product deterioration, while reducing the weight of the container.

In the case of pharmaceuticals, since the allowable temperature range during storage is limited by product or country, a transport container that can provide a calming effect without exceeding the allowable temperature range for the time required for storage and transportation is required. In particular, in the case of vaccines, cryogenic temperatures of -20 °C to -80 °C as well as refrigeration temperature range of 2 °C to 8 °C are required, and transport is performed using PCM or dry ice at such a temperature. Especially useful.

In temperature control technology, controlling the temperature in a specific temperature range is technically much more difficult than controlling the temperature below a specific temperature. For example, controlling the temperature in a temperature range of about 2 °C to 8 °C is technically more difficult than controlling the temperature only at 8 °C or less, and in particular, it is not easy to provide such a container.

In this regard, there are attempts to use transportation equipment or transportation means including refrigerated or refrigerating containers, but temperature control failure due to environmental changes such as loading and unloading processes or changes in transportation means may be a problem. Also, there is a risk of errors in setting the refrigeration or freezing conditions.

In addition, in the delivery of medicines, in many cases where the product is deteriorated due to failure to maintain temperature during transportation, it is due to a problem occurring in the packaging container. According to the embodiments of the present invention, this problem can be solved, and energy can be saved because the temperature control of the warehouse does not need to be included to operate the cold chain.

According to the present invention, by locating an insulating material, for example, a vacuum insulating material, between the outer box and the body portion, it is possible to protect the insulating material vulnerable to the external environment by preventing direct contact with the phase change material without exposing it to the outside. In addition, the present invention can protect the product from other transport hazards.

Hereinafter, with reference to the drawings, a cold chain medicine transport container according to embodiments of the present invention will be described in detail.

1 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to Figure 1, the cold chain medicine transport container 1 according to an embodiment of the present invention includes a body portion 11 in which medicines are accommodated, body insulators 13a, 13b, 13c, an outer box 15, It may include a cover part 21 and a refrigerant.

The body 11 may have a bottom wall and a plurality of side walls extending upwardly from the bottom wall to define an internal space 40, and the internal space 40 includes Articles including pharmaceuticals may be accommodated. In particular, since the lower wall and the plurality of side walls are integrally formed, a thermal bridge can be prevented or minimized compared to a case where the lower wall and the plurality of sidewalls are separately formed and assembled, thereby improving the thermal insulation performance of the body 11 .

The body portion 11 is a part that forms the skeleton of the entire container and has high strength and durability, so it can withstand shocks that may occur during transportation, while providing sufficient thermal insulation effect so that the cold air in the internal space does not leak to the outside, It should be made of a material that allows the container to be manufactured at a weight suitable for transport that may be weight-restricted, for example, air transport. In addition, the material forming the body should have easy formability so that the container can be manufactured into a container structure for preventing thermal bridges.

In one embodiment of the present invention, the body portion 11 is made of a foamed plastic, in particular, it may be made of a foamed polypropylene material. Foamed polypropylene is a type of foamed plastics, and by forming closed cells, it has excellent thermal insulation performance compared to weight without additional treatment.

In the case of expanded polypropylene, compared to other materials, it has excellent cushioning or shock absorption ability against repeated impacts. In addition, it is possible to reduce the weight and secure relatively high strength and durability. By using foamed polypropylene in the body of the medicine transport container by utilizing these characteristics, even when transporting medicines over long distances or using transport means with weight restrictions, it enables easy delivery without damage due to impact or the like.

In addition, expanded polypropylene is a recyclable, eco-friendly material that is harmless to the human body and has excellent chemical resistance. For this reason, in the present invention, foamed polypropylene is employed as a material for the body of the pharmaceutical container, and the pharmaceutical container placed adjacent to the secondary accident that may occur during transportation of the medicine, for example, leakage, leakage of medicine, etc. Keep staff safe.

On the other hand, in the case of expanded polystyrene, it has the advantage of easy moldability and cheapness, but has a thermal conductivity of 31 to 43 mW/mK (KS M 3808), so the thermal conductivity is high and the density is low. In addition, since it is vulnerable to heat and has a relatively high absorption rate of 2 to 4%, there may be concerns about a decrease in thermal insulation properties. As another example, in the case of polyurethane foam, it has a thermal conductivity of 23 to 25 mW / mK (KS M 3809), shrinkage may occur over time, and there is a risk of toxic gas being emitted when ignited. There is this.

In the present invention, the expanded polypropylene can be prepared by adjusting the expansion ratio as necessary. In one embodiment of the present invention, the body 11 may adopt a polypropylene foam material having an expansion ratio of 25 to 45 times, and preferably adopt a polypropylene foam material having an expansion ratio of about 30 times. can do.

Here, the expansion ratio indicates how many times the volume is the same mass compared to that of a solid (for example, a synthetic resin molded product), and it can be defined as a value obtained by dividing the apparent density of the foamed plastic by the density of the synthetic resin before foaming. .

The lower the expansion ratio, the closer to the solid properties, the stronger the foamed polypropylene is, and the stronger it is against external damage. may be more affected. The present inventors have found the optimal expansion ratio for application to pharmaceutical containers when using expanded polypropylene as a material. Specifically, the thermal insulation performance of each expanded polypropylene was measured by varying the expansion ratio of polypropylene by 10 times, 15 times, 30 times, and 45 times while the other conditions were the same. As a result, each 43.84 mW/mK , 40.61 mW/mK, 36.95 mW/mK, and 37.28 mW/mK. In addition, when comparing the weight based on the same volume, the larger the expansion ratio, the lower the weight.

Accordingly, while maintaining excellent thermal insulation performance of the body 11, the weight of the body 11 was reduced to find the optimal material and foaming ratio to realize the weight reduction of the medicine transport container 1 for the cold chain. In addition, as will be described later, by arranging the body insulators 13a, 13b, 13c and the outer box 15 on the outer surface of the body portion 11, the risk that may be relatively vulnerable to external damage due to a high expansion ratio removed. Accordingly, the cold chain medicine transport container 1 of the present invention may have a light and strong characteristic against external damage.

In this specification, the inner surface of the body portion 11 (lower wall, a plurality of side walls) refers to the surfaces facing the interior space 40 in FIG. 1 , and of the body portion 11 (lower wall, a plurality of side walls) The outer surface may refer to surfaces facing or in contact with the body insulators 13a, 13b, and 13c in FIG. 1 . In addition, the inner surfaces of the body insulators 13a, 13b, and 13c may refer to surfaces facing or in contact with the body 11 in FIG. It can refer to the faces facing or touching (15). Also, the outer surface of the cover part 21 may refer to surfaces facing or in contact with the outer box 15 in FIG. 1 .

The body heat insulating materials 13a , 13b , and 13c may be disposed on the outer surface of the body portion 11 . Specifically, the body heat insulating material 13b may be disposed on the outer surface of the lower wall of the body portion 11 , and the body heat insulating materials 13a and 13c may be disposed on the outer surface of the plurality of side walls of the body portion 11 . Here, the body heat insulating material (13a, 13b, 13c) is preferably a vacuum insulating material, for example, may be a plate-shaped vacuum insulating material.

A vacuum insulation material realizes a significantly lower thermal conductivity than a general insulation material by wrapping a core material having thermal insulation performance with an outer skin material composed of a gas barrier film with low gas permeability to form a vacuum.

As a core material of the vacuum insulation material, it may be manufactured to include any one or more of materials with low thermal conductivity such as organic fibers, inorganic fibers, powders, and foam insulation materials, and if it can be disposed inside the outer shell material, any material is used. can be used. In addition, the core material may be manufactured using a single material, may be manufactured using a mixed material, may be manufactured to have a single layer structure, or may be manufactured to have a laminated structure.

The outer covering material surrounding the core material is manufactured in the form of a film to prevent gas and moisture permeation to maintain a high vacuum state, protect and seal the core material, and block thermal radiation. The shell material may be manufactured to include at least one of PET (Polyethylene Terephthalate), EVOH (Ethylene Vinyl alcohol), PVOH (Polyvinyl alcohol), nylon (Nylon), and PE (Polyethylene), and aluminum formed by deposition or sputtering as a metal layer It may be manufactured to include foil or copper foil.

The adsorbent disposed together with the core material in the outer shell material serves to adsorb gas and moisture inside the vacuum insulator to uniformly maintain the internal vacuum. Calcium oxide (CaO), magnesium oxide (MgO), silicon dioxide (SiO ₂ ), etc. may be used as the adsorbent, but the scope of the present invention is not limited thereto.

However, since the envelope material of the vacuum insulation generally uses a thin plate (for example, a thin aluminum plate of 8 um level), there is a risk that gas and moisture may pass through the damaged area when the envelope is damaged, Accordingly, thermal insulation performance may be significantly reduced. As a cause of damage to the envelope, a case in which a vacuum insulation material collides with an article during transportation or storage of a container, or a case where a vacuum insulation material collides with a refrigerant for maintaining the temperature of the article.

Accordingly, in the cold chain medicine transport container 1 according to this embodiment, the refrigerant and the article are disposed on the inside with respect to the body part 11, and the body heat insulating materials 13a, 13b, 13c are disposed on the outside thereof. It is designed to prevent damage to the body insulator (13a, 13b, 13c) that may occur due to a collision with an article or a refrigerant during transportation or storage. In addition, the outside of the body insulator (13a, 13b, 13c) is designed to be protected by the outer box 15, body insulation that may occur from the outside of the cold chain medicine transport container 1 during transportation or storage (13a, 13b, 13c) damage can be prevented. Accordingly, the body heat insulating material (13a, 13b, 13c) constituting the cold chain medicine transport container (1) is reliably protected in any situation, it is possible to maintain the insulation performance semi-permanently.

The body insulators 13a, 13b, and 13c may be formed of one or more plate-shaped vacuum insulators. The one or more plate-shaped vacuum insulators may be disposed on the outer surface of the lower wall of the body 11 and at least one of the outer surfaces of the four side walls. In addition, one plate-shaped vacuum insulator may be disposed on one outer surface, or two or more plate-shaped vacuum insulators may be disposed on one outer surface.

On the other hand, the body heat insulating material (13a, 13b, 13c) is disposed on the five outer surfaces of the body portion 11 may form a seam at the edge of each outer surface is connected. In order to minimize the thermal bridge phenomenon through the seam, the body insulators 13a, 13b, and 13c may be disposed in such a way that the corners do not face each other and face to face. For example, as shown in FIG. 1 , the side surface of the body heat insulating material 13b is disposed to face the side surface of the body heat insulating material 13a and 13c, so that the seam space can be minimized. Accordingly, it is possible to minimize the deterioration of the insulation performance due to the thermal bridge phenomenon.

1 shows a case in which the body insulators 13a, 13b, and 13c are formed of a plate-shaped vacuum insulation material, but the scope of the present invention is not limited thereto, and the body insulation is formed of a single three-dimensional structure type vacuum insulation material folded to have a three-dimensional structure. it might be In this case, the body insulation material may be formed by folding a single vacuum insulation material that can be spread on a single plane to have a three-dimensional structure corresponding to five adjacent surfaces of a cube (or cuboid). The three-dimensional structure of the folded body heat insulating material may have a lower surface and a plurality of side surfaces extending upwardly from the lower surface. When the body heat insulating material is formed of a single vacuum insulating material, since there is no seam itself, it is possible to further increase the thermal insulation performance compared to the case of using a plate-shaped vacuum insulating material disposed to face the surface.

In this embodiment, the thickness of the body heat insulating material (13a, 13b, 13c) may be 3 mm to 30 mm, preferably 10 mm to 30 mm, more preferably about 25 mm. As will be described later with reference to FIGS. 19 and 20, when the body heat insulating materials 13a, 13b, and 13c are manufactured to have a thickness in the range of 10 mm to 30 mm, the temperature holding time is secured for 125 hours or more, especially 25 mm It was found that the temperature holding time was secured for 140 hours when having a thickness of .

As such, by adopting the body portion 11 having a relatively low-density characteristic and the body insulators 13a, 13b, and 13c having a relatively high density but superior thermal insulation performance together, the cold chain medicine transport container (1) It is possible to secure the insulation performance and at the same time realize the weight reduction, so that transportation convenience can also be obtained.

In particular, in some embodiments of the present invention, the thickness (A, C) of the body portion 11 and the thickness (B, D) of the body insulating material may be formed to be substantially the same. Here, the meaning of the term “substantially the same” may mean a case in which a difference in thickness values is within about 5 mm.

The outer box 15 may be disposed on the outside of the body heat insulating material (13a, 13b, 13c). Specifically, the outer box 15 may be formed to surround the outer surfaces of the body portion 11 , the body heat insulating materials 13a , 13b , 13c , and the cover portion 21 . For example, in a state in which one side of the outer box 15 is opened, the body portion 11, the body heat insulating materials 13a, 13b, 13c, and the cover portion 21 are accommodated in the outer box 15, and the outside By closing the open side of the box 15 , the body 11 , the body insulators 13a , 13b , 13c , and the cover 21 can be completely protected from the outside.

The outer box 15 may be made of a material such as plastic or paper, and may be, for example, a Danpla box or a paper cardboard box. As described above, the outer box 15 serves to protect the body portion 11, which may be relatively vulnerable to external damage due to the high expansion ratio, and the body insulators 13a, 13b, 13c that may be damaged by the outer shell material. In the end, it is possible to prevent loss of insulation effect due to physical damage to the medicine transport container 1 for the cold chain.

In addition, only the outer box 15 can be replaced, so even if the outer surface of the cold chain medicine transport container 1 is damaged, the body portion 11, the body insulation materials 13a, 13b, 13c, etc. There is an advantage of enabling long-term or semi-permanent use of parts.

The cover part 21 may cover the upper part of the body part 11 to seal the internal space 40 . According to a specific design purpose, the cover part 21 may be formed to accommodate the cover insulating material 23 therein, or may be formed of only a single material without accommodating it. When the cover unit 21 includes the cover insulating material 23 , the cover unit 21 may further include a cap unit 25 disposed to cover the cover insulating material 23 . That is, the cap part 25 may be disposed to contact the upper surface or the lower surface of the cover insulating material 23 . Due to this design, the vacuum insulating material can be arranged on six sides around the inner space 40, so that the temperature of the article transported through the medicine transport container 1 for cold chain can be reliably maintained.

When it is closed by the cover part 21 and the cap part 25 that combine with the body part 11 to form a closed space, durability and heat insulation effect for the cover insulating material 23 in all directions are provided. Therefore, the cover part 21 and the cap part 25 of the present invention are preferably made of the same material as the body part 11, for example, may be made of polypropylene foam.

In this embodiment, the thickness of the cover insulation material 23, for the same reason as in the case of the body insulation material (13a, 13b, 13c), may be 3 mm to 30 mm, preferably 10 mm to 30 mm, more preferably may be about 25 mm.

The refrigerant may be a plurality of PCMs 30a, 30b, 30c or dry ice. Specifically, a plurality of PCMs 30a, 30b, and 30c may be disposed on the inner surface of the lower wall of the body 11 and the inner surface of the plurality of side walls, and the internal space 40 includes a plurality of PCMs 30a, 30b , 30c).

The phase change material is a material that absorbs or releases a lot of heat while the state of the material changes, and can be used as a refrigerant together with ice packs, gel packs, and dry ice. In particular, the internal space 40 due to the heat transfer effect occurring in the phase change material temperature can be maintained at a constant temperature. As a phase change material, a material with high thermal conductivity, low temperature gradient during heat storage and dissipation, small volume change during phase change, no supercooling phenomenon, chemical stability, and excellent thermal properties such as latent heat and specific heat can be used

The PCMs 30a, 30b, and 30c may use phase change materials having different temperature ranges depending on specific purposes, and commercially available phase change materials may be used.

The PCMs 30a, 30b, and 30c may be manufactured by injecting a phase change material into a container (eg, a plastic container) made of a material without deformation at the target temperature of the internal space 40 , the cross-section of the container is shown in FIG. 1 It may have a trapezoidal shape as shown in .

Specifically, the left edge of the PCM 30b disposed on the inner surface of the lower wall of the body 11 is diagonal to the lower edge of the PCM 30a disposed on the inner surface of the left wall of the body 11 . In contact with, the right edge of the PCM (30b) is in diagonal contact with the lower edge of the PCM (30c) disposed on the inner surface of the right wall of the body portion 11 in the diagonal direction, so that the PCM (30a, 30b, 30c) is fixed to each other. can be Alternatively, although not shown in FIG. 1, an additional PCM (30d) is in contact with the upper edge of the PCM (30a) in a diagonal direction and in contact with the upper edge of the PCM (30c) in a diagonal direction to cover the interior space (40). It may be arranged to be fixed with the PCM (30a, 30b, 30c).

Due to the trapezoidal cross-sectional structure of these PCMs (30a, 30b, 30c, 30d), even in a situation where the cold chain medicine transport container (1) is shaken or shocked during transport, the PCM (30a, 30b, 30c, 30d) The risk of colliding with the goods accommodated in the interior space 40 as at least one of the PCMs 30a, 30b, 30c, and 30d is tilted during transportation, as well as being able to maintain the thermal insulation performance by being firmly fixed to each other can also be prevented.

It should be noted that, as used herein, the term trapezoidal shape does not mean only the shape shown in FIG. 1 , and includes a shape in which diagonal faces are formed that allow PCMs to support each other, although not exactly trapezoidal. 23 is a view for explaining a modification of the trapezoidal cross-sectional shape of the PCM that can be used in the cold chain medicine transport container according to an embodiment of the present invention. For example, in the case of FIG. 1 , if the cross-sectional structure of the PCM is formed along the AC line along the diagonal side, the cross-sectional structure of the PCM is along the AB line as in the case of FIG. 22 . Some vertical planes formed and along the BC line may be formed.

Articles including medicines may be accommodated in the inner space 40 . In some embodiments of the present invention, the article may be accommodated by an inner packaging material, which may be an inner box in the form of a box or a protective insulating packaging material such as an air cap, etc., which may be used alone or in combination. When used in the form of a box, it may be manufactured to form a handle for facilitating separation and placement by making a hole in the top.

According to this embodiment, the body heat insulating material (13a, 13b, 13c) is located on the outside of the body portion 11, and direct contact with the PCM (30a, 30b, 30c) located inside the body portion 11 during transportation this doesn't happen Unlike the general delivery process, cryogenic PCM is used in the transport process of medicines, eg, vaccines, and the temperature of PCM at this time reaches a temperature of -20 °C to -80 °C. A vacuum insulation material that was not damaged when in contact with PCM at a typical refrigeration temperature, for example, 2°C to 8°C, is damaged when in contact with PCM of such cryogenic temperature, and the film is damaged, thereby lowering the calming effect. However, the cold chain medicine transport container 1 of the present invention has a body insulator (13a, 13b, 13c) located on the outside of the body portion 11 and PCM (30a, 30b, 30c) located inside the body portion 11. ), it is possible to prevent such damage.

Accordingly, the vacuum insulation material constituting the body insulation material (13a, 13b, 13c) does not have a risk of damage due to collision with an article or a refrigerant during transportation or storage, so the material of the vacuum insulation material, especially the material of the outer covering material, can be selected widely. The effect of being there occurs.

In addition, by adopting the body portion 11 having a relatively low-density characteristic and the body insulators 13a, 13b, and 13c having a relatively high density but superior thermal insulation performance together, the insulation of the medicine transport container 1 for a cold chain While securing performance, it is possible to realize weight reduction at the same time. When air transport is used to transport medicines, the transportability and cost can vary greatly depending on the weight range. While achieving light weight suitable for air transport, the insulation effect is improved compared to the conventional cold chain drug transport container. We can provide pharmaceutical transport containers for cold chain use.

Figure 2 is a view showing the body portion and the cover portion of the cold chain medicine transport container according to an embodiment of the present invention.

Referring to FIG. 2 , an embodiment in which the cover part 21 covers the upper part of the body part 11 is illustrated. In this embodiment, the cover portion 21 may be formed with a handle (H). As shown, as the handle (H) is formed in a form in which some of the corners of the cover part 21 are dug, handling ease can be improved when handling the cold chain medicine transport container. Of course, different from that shown in FIG. 2 , the handle H may be formed on at least two of the corners of the cover part 21 . In this way, as the handle H is formed on the cover part 21, there is no need to additionally form the handle to protrude to the outside of the cold chain medicine transport container, so it is not only easy to handle, but also the cold chain medicine transport container. Ease of loading can also be ensured.

Meanwhile, at least one of the body part 11 and the cover part 21 may be treated with an appearance to improve the aesthetics. For example, in some embodiments of the present invention, at least one of the body portion 11 and the cover portion 21 may be embossed. Accordingly, the exterior may be treated so that the EPP bead shape is not visible on the surface of at least one of the body portion 11 and the cover portion 21 . For another example, in some embodiments of the present invention, the appearance of at least one of the body portion 11 and the cover portion 21 is treated such that the surface thereof is expressed by a different material (eg, leather or other material). it might be Due to such external treatment, the marketability of the medicine transport container for cold chain itself can be improved.

3a and 3b are views showing a cover part of a cold chain medicine transport container according to an embodiment of the present invention, and FIGS. 4a and 4b are cross-sections of a cold chain medicine transport container according to an embodiment of the present invention drawings shown.

Referring to FIG. 3A , when the cover part 21 includes the cover insulating material 23 therein, the cap part is disposed on the lower or upper surface of the cover insulating material 23 to cover the cover insulating material 23 . (25) may be formed in a plate shape to be closely coupled to the cover portion (21).

Specifically, the cover 21 includes a protrusion 115 extending toward the inner space 40 , for example, a rib, and a long groove is formed inside the protrusion 115 . On the other hand, on the four relatively narrow side surfaces of the cap part 25, protrusions formed to correspond to the position and size of the grooves of the cover part 21 are formed to be long. Accordingly, after disposing the cover insulating material 23 on the portion bordered by the protrusion 115 of the cover portion 21, the cover portion 21 is closely coupled in a manner that fits the groove of the cover portion 21 and the protrusion of the cap portion 25. This can be done. In this case, the cap part 25 is disposed on the lower surface of the cover insulating material 23 to cover the cover insulating material 23 .

Of course, the shapes, positions, and numbers of the protrusions and grooves shown in FIG. 3A are exemplary, and the shapes, positions, and numbers of the protrusions and grooves may vary according to specific purposes. In addition, differently from the drawings, a protrusion may be formed on the protrusion 115 of the cover part 21 and a groove may be formed on the cap part 25 .

Also, referring to FIG. 3B , a protrusion 111 , for example, a rib is formed on the body 11 , and a protrusion 113 is formed on the protrusion 111 . On the other hand, a concave portion 211 is formed in the cover portion 21 , and a long groove 213 is formed inside the concave portion 211 to correspond to the position and size of the protrusion 113 of the protruding portion 111 , have. Accordingly, when the cold chain medicine transport container is closed, the protrusion 113 formed on the protrusion 111 of the body 11 and the groove 213 formed on the concave portion 211 of the cover 21 are formed. Adhesive bonding may be achieved by fitting the .

Of course, the shapes, positions, and numbers of the protrusions and grooves shown in FIG. 3B are exemplary, and the shapes, positions, and numbers of the protrusions and grooves may vary according to specific purposes. In addition, differently from the illustration, a protrusion may be formed in the concave portion 211 of the cover portion 21 and a groove may be formed in the protrusion 111 of the body portion 11 .

In this way, the fastening force between the cover part 21 and the cap part 25 and the fastening force between the body part 11 and the cover part 21 can be increased. However, the ribs may be formed so that the degree of their protrusion is minimized in a range that prevents them from being ruptured or torn at very low temperatures.

Then, referring to FIG. 4A , the cap part 25 may be disposed on the lower surface side of the cover part 21 , and referring to FIG. 4B , the cap part 26 may be disposed on the upper surface side of the cover part 21 . . In the former case, the cap part 25 is disposed on the lower surface of the cover insulator 23 to cover the cover insulator 23 , and in the latter case, the cap part 26 is disposed on the lower surface of the cover part 21 to insulate the cover. (23) is covered.

Due to the coupling structure of the cover part 21 and the cap parts 25 and 26 , the entire cover insulation material 23 can be protected from external damage, and the inner space 40 of the body part 11 is the center As a vacuum insulation material is arranged on 6 sides, it is possible to secure the insulation performance of the medicine transport container for the cold chain.

5 is a view showing the PCM of the medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 5 , the PCM 30 is formed in a three-dimensional structure having a trapezoidal cross-section as described above, and a handle for easy insertion into or removal from the body 11 is provided. can be formed. In addition, in order to increase the heat transfer efficiency of the phase change material, a structure for increasing the surface area of the container into which the phase change material is injected (a structure dented in a circle) may be formed in the PCM 30, and the number and formation position thereof are It may vary depending on the specific purpose.

In some embodiments of the present invention, the medicine transport container for cold chain may further include a data logger. The data logger can record data by sensing the internal space 40 of the medicine transport container for cold chain, and can respond to changes in the environment that may occur during transport.

For example, a data logger can collect information about the temperature and humidity in a medicine transport container for a cold chain, transport location, and the like. To this end, the data logger may be equipped with a sensor capable of measuring temperature and humidity, a GPS sensor capable of receiving GPS (Global Positioning System) positioning information, and various other sensors necessary according to the information to be collected. For example, when it is necessary to collect impact data to analyze the impact condition that may occur during transportation of a medicine transport container for a cold chain, an acceleration sensor for detecting the impact amount can be mounted on the data logger.

In addition, the data logger may include a processor (eg, microcontroller unit (MCU)) capable of processing the collected data, a memory device or storage device capable of storing the collected data, a battery, a power control device controlling the battery, etc. In addition, the data logger may further include a communication chip or a communication interface device for transmitting the collected data or meta information related to the collected data to the outside through a communication network. , a wireless network, and combinations thereof In addition, the data logger may further include a display device capable of displaying the collected data or meta information related to the collected data to the user.

From the information collected by the data logger, it is possible to accurately grasp the situation in which the article is stored in the insulated container 1 of the cold chain drug transport container or the cold chain drug transport container in which the article is loaded is being transported.

6 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 6 , the medicine transport container 2 for cold chain according to an embodiment of the present invention further includes an additional heat insulating material 17 disposed on the outer surface of the body heat insulating material 13a, 13b, 13c. It has a difference from the medicine transport container (1) for the cold chain.

The additional insulation 17 may be formed of a vacuum insulation material like the body insulation materials 13a, 13b, and 13c, and by forming a double structure with the body insulation materials 13a, 13b, 13c, a cold chain medicine transport container ( The insulation performance of 2) can be further improved.

In this embodiment, the thickness of the additional heat insulating material 17 may be formed to be thinner than the thickness of the body heat insulating material (13a, 13b, 13c). For example, the thickness of the body insulation materials 13a, 13b, 13c is in the range of 3 mm to 30 mm, preferably in the range of 10 mm to 30 mm, and the thickness of the additional insulation material 17 is in the range of 3 mm to 10 mm. range can be formed. In particular, the thickness of the body heat insulating material (13a, 13b, 13c) is formed to be about 25 mm, the thickness of the additional heat insulating material 17 may be formed to be about 5 mm.

On the other hand, the additional heat insulating material 17 may be formed of a plurality of plate-shaped vacuum insulation materials similar to the case of the body insulation materials 13a, 13b, 13c, or may be formed of a single three-dimensional structure type vacuum insulation material folded to have a three-dimensional structure. . In this case, the additional insulating material 17 may be formed by folding a single vacuum insulating material that can be spread on a single plane to have a three-dimensional structure corresponding to five adjacent surfaces of a cube (or cuboid). The three-dimensional structure of the folded additional heat insulating material 17 may have a lower surface and a plurality of side surfaces extending upwardly from the lower surface. When the additional heat insulating material 17 is formed of a single vacuum insulating material, since there is no seam itself, it is possible to further increase the insulating performance than when using the plate-shaped vacuum insulating material disposed to face the surface.

In FIG. 6 , the additional insulating material 17 is shown to extend upward to reach the body part 11 , but the scope of the present invention is not limited thereto, and the additional insulating material 17 reaches the body part 11 . It may be formed to extend only enough to cover only a portion of the body heat insulating materials 13a and 13c. In addition, the additional heat insulating material 17 is disposed only on the bottom surface of the outer box 15 , and may not be disposed along the side surface of the outer box 15 .

Thus, by disposing the additional heat insulating material 17 on the outer surface of the body heat insulating material (13a, 13b, 13c), it is possible to further increase the thermal insulation performance of the cold chain medicine transport container (2).

In some embodiments of the present invention, the thickness (A, C) of the body portion 11 and the thickness (B, D) of the body insulating material may be formed to be substantially the same. Here, the meaning of the term “substantially the same” may mean a case in which a difference in thickness values is within 5 mm. However, the scope of the present invention is not limited thereto, and as will be described later with reference to FIG. 7 , even when the thickness (B) of the body insulation material is formed to be thicker than the thickness (D) of other body insulation materials, the additional insulation material (17) It is obvious that it can be applied.

On the other hand, unlike the above, the additional heat insulating material 17 may be disposed on the inner surface of the body heat insulating material (13a, 13b, 13c). That is, the additional insulating material 17 is different from that shown in FIG. 6 , between the body part 11 and the body insulating materials 13a, 13b, 13c, that is, the outer surface of the body part 11 and the body insulating materials 13a, 13b, 13c. ) may be disposed between the inner surfaces of the In this specification, the outer surface of the body insulation refers to the surface facing the outer box, and the inner surface refers to the surface facing the body portion.

In addition, if the additional insulating material 17 is formed of a plurality of plate-shaped vacuum insulators, some of the plurality of plate-shaped vacuum insulating materials are disposed on the outer surface of the body insulator (13a, 13b, 13c), and the other part is the body insulator (13a) , 13b, 13c) may be disposed on the inner surface.

7 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to Figure 7, the cold chain medicine transport container (3) according to an embodiment of the present invention, the body heat insulating material (13b) disposed on the outer surface of the lower wall of the body heat insulating material (13a, 13b, 13c) It has a difference from the cold chain medicine transport container 1 in that the thickness is formed to be thicker than the thickness of the body heat insulating materials 13a and 13c disposed on the outer surfaces of the plurality of sidewalls.

For example, the thickness of the body insulator 13b may be about 30 mm, and the thickness of the body insulator 13a and 13c may be about 25 mm.

In addition, the thickness of the cover insulator 23 may be formed to be thinner than that of the body insulator 13b disposed on the outer surface of the lower wall among the body insulators 13a, 13b, and 13c. For example, the thickness of the body insulator 13b may be formed to be about 30 mm, and the thickness of the cover insulation material 23 may be formed to be about 25 mm.

Of course, the scope of the present invention is not limited to that shown in FIG. 7 , and at least a portion of the body heat insulating materials 13a , 13b , 13c and the cover heat insulating material 23 and other parts may be formed to have different thicknesses. For example, different from the above, the thickness of the body heat insulating materials 13a and 13c disposed on the outer surface of the side wall according to a specific purpose may be formed to be thicker than that of other body heat insulating materials, or the thickness of the cover insulating material 23 may be formed thicker than other body insulation materials.

In this way, by finely adjusting the thicknesses of the body insulation materials 13a, 13b, 13c and the cover insulation material 23 to achieve a target static temperature effect, the transportation or storage temperature required according to the medicines being transported or stored can be precisely adjusted can be implemented

8 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 8 , the cold chain medicine transport container 4 includes a refrigerant box 32 disposed in a partial space inside the body 11 , and the internal space 42 is inside the body 11 . It is different from the medicine transport container (1) for cold chain in that it is defined in another part of the space.

The refrigerant box 32 includes a refrigerant, for example, dry ice, and FIG. 8 shows that the inner space 42 is disposed at the lower portion and the refrigerant box 32 is disposed at the upper portion, but the scope of the present invention is limited thereto. doesn't happen That is, different from that shown in FIG. 8 , the inner space 42 may be disposed on the upper portion, and the refrigerant box 32 may be disposed on the lower portion.

Figure 9a is an exploded view showing a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 9A , when the inner space 42 is disposed at the lower portion and the refrigerant box 32 is disposed at the upper portion, the product 43 is accommodated in the inner packaging box 44, and the inner packaging box 44 is a box The guide 45 may be fixedly coupled to the body 11 . Here, the box guide 45, for example, may be manufactured to engage corrugated cardboard and corrugated cardboard, but the scope of the present invention is not limited thereto, and the inner packaging box 44 is stably attached to the body 11 . If the structure can be fixed, it may be formed of any structure of any material. When the corrugated cardboard and the corrugated cardboard are manufactured to engage, a refrigerant, for example, dry ice, may be additionally disposed in the space between the box guide 45 and the body 11 .

In this way, when dry ice is put in the refrigerant box 32 and brought into contact with the inner packaging box 44 fixed to the body 11 through the box guide 45, it is more effective in maintaining the temperature of the product 43. . The reason is that when dry ice comes into contact with air, its sublimation rate increases. This is because, due to the structure of the refrigerant box 32 and the box guide 45, contact between dry ice and air can be blocked or minimized, and also , dry ice pellets can be arranged and stored, and by adopting the above structure, the refrigerant box 32 configured separately from the product 43 can be lifted, so user convenience when taking out the product 43 can be expected. can In addition, it is also possible to prevent the dry ice from directly contacting the product 43 to damage the product 43 . Here, the entire lower surface of the refrigerant box 32 may contact the inner packaging box 44 , and only a portion of the lower surface of the refrigerant box 32 may contact the inner packaging box 44 . In the present specification, in addition to this, the lower surface of the refrigerant box 32 and the inner packaging box 44 do not physically contact, but the dry ice contained in the refrigerant box 32 can provide cold air to the inner packaging box 44 . It should be noted that the refrigerant box 32 is expressed as being disposed to contact the inner packaging box 44 up to the concept including the case where it is spaced apart at a level that is there.

In addition, as described above, when the vacuum insulating material is in contact with a cryogenic temperature, the film is damaged and the static effect is deteriorated. However, the cold chain medicine transport container 4 of the present invention adopts the arrangement structure of the body insulators 13a, 13b, 13c located outside the body 11 and dry ice located inside the body 11 . By doing so, such damage can be prevented.

Accordingly, the vacuum insulation material constituting the body insulation material (13a, 13b, 13c) does not have a risk of damage due to collision with an article or a refrigerant during transportation or storage, so the material of the vacuum insulation material, especially the material of the outer covering material, can be selected widely. The effect of being there occurs.

The refrigerant box 32, the inner packaging box 44, and the box guide 45 may be made of a paper material, but the scope of the present invention is not limited thereto, and any suitable material in consideration of the insulation effect and robustness, etc. can be adopted. In particular, the refrigerant box 32 may further secure a cooling effect by adopting a material having high thermal conductivity in addition to the paper material.

Meanwhile, in some embodiments of the present invention, the refrigerant box 32 and the inner packaging box 44 may be provided with handles for ease of handling.

In this specification, PCM and dry ice have been described as examples of refrigerants for convenience of explanation, but the scope of the present invention is not limited thereto, and if it can be maintained in a form that can be mounted on a cold chain medicine transport container, the cooling action It can be made of any material that causes

9b to 9d are views showing a medicine transport container for a cold chain according to various embodiments of the present invention.

Referring to FIG. 9B , one or more holes 33 may be formed in the bottom surface of the refrigerant box 32 . And the refrigerant box 32 is stacked on the inner packaging box 44 containing the product 43, one or more holes 33 formed in the bottom surface of the refrigerant box 32 may not be covered.

To this end, the area of the bottom surface of the refrigerant box 32 may be smaller than the area of the top surface of the inner packaging box 44 . In addition, at least one side of the side surfaces of the refrigerant box 32 may be disposed to protrude more outward than the side surface of the inner packaging box 44 , and disposed to protrude further outward among the bottom surfaces of the refrigerant box 32 . A hole 33 may be formed on the bottom surface between the side of the inner packaging box 44 and the side of the refrigerant box 32 disposed further inside.

One or more holes 33 in the bottom surface of the refrigerant box 32 may be formed to extend long in a direction along the side edge of the inner packing box 44 as shown in FIG. 9B, and the inner packing box 44 One hole 33 may be formed per one side of the , or two or more holes 33 may be formed. Of course, the shape of the hole 33 may be formed in an arbitrary shape other than that shown in FIG. 9B .

According to this embodiment, the cold air provided from the dry ice disposed in the refrigerant box 32 can directly reach the sides of the inner packaging box 44 through the one or more holes 33 formed in the bottom surface, The cooling effect on the inner packaging box 44 , that is, the product 43 may be further increased. In addition, although the dry ice does not all sublimate and remains in the refrigerant box 32, there may be a case where the cooling effect on the inner packaging box 44 is insignificant due to the small amount of the dry ice. The effect of concentrating the cooling effect that occurs until all of the dry ice sublimes and disappears through one or more holes 33 formed in the bottom surface can be obtained in the inner packaging box 44 .

Referring to Figure 9c, as a top view of the inside of the refrigerant box 32, along the four sides of the refrigerant box 32 on the bottom surface, eight holes 33 formed by two for each side are illustrated. . At this time, the interval between the hole 33 and the side surface of the refrigerant box 32 may be appropriately determined according to the size of the inner packaging box 44 to be stacked under the refrigerant box 32 . Then, when the inner packaging box 44 is surrounded by the box guide 45, the thickness of the box guide 45 must be additionally considered, so the gap between the hole 33 and the side of the refrigerant box 32 is the box guide (45) can be determined to be narrower than in the absence.

That is, one or more holes 34 may be formed in the bottom surface of the refrigerant box 32 , and the refrigerant box 32 is stacked on the inner packaging box 44 containing the product 43 , the inner packaging box 44 may be surrounded by the box guide 45, and the gap between the hole 34 and the side of the refrigerant box 32 is one or more holes 34 formed in the bottom surface of the refrigerant box 32. It may be prevented from being covered by the packaging box 44 and the box guide 45 .

Fig. 9d is a cross-sectional view of a container structure according to the embodiment according to Fig. 9b;

Referring to FIG. 9D , the cold chain medicine transport container 4 includes an inner packaging box 44 and a refrigerant box 32 vertically stacked inside the body 11 , It may include a body insulator (13a, 13b, 13c), an outer box (15) and a cover part (21) located outside, the body part (11), the body insulator (13a, 13b, 13c), the outer box (15) ) and for various configurations of the cover part 21, reference may be made to the contents of the above-described embodiments.

In the stacked structure of the inner packaging box 44 and the refrigerant box 32 , the width of the refrigerant box 32 is formed to be greater than the width of the inner packaging box 44 , and the inner packaging of the bottom surface of the refrigerant box 32 . A hole 33 may be formed in the bottom surface not covered by the box 44 .

In addition, according to this embodiment, due to the stacked structure of the inner packaging box 44 and the refrigerant box 32 having different widths, an additional refrigerant arrangement area ( 35) can be defined.

A refrigerant including dry ice may be disposed in the additional refrigerant arrangement area 35 , so that, according to this embodiment, cold air provided from the dry ice disposed in the refrigerant box 32 is formed in one or more holes 33 in the bottom surface. A stronger cooling effect can be secured as cold air is additionally provided from the additional dry ice disposed in the additional refrigerant arrangement area 35 while directly reaching the side surfaces of the inner packaging box 44 through the .

The medicine transport container 4 for cold chain includes an inner packaging box 44 and a refrigerant box 32 stacked vertically inside the body 11 , and the inner packaging box 44 is a box guide 45 . It is surrounded by and may include a body heat insulating material (13a, 13b, 13c), an outer box 15 and a cover part 21 located outside of the body part 11, the body part 11, the body insulating material ( 13a, 13b, 13c), for various configurations of the outer box 15 and the cover part 21, reference may be made to the contents of the above-described embodiments.

In the stacked structure of the inner packing box 44 and the refrigerant box 32 , the width of the refrigerant box 32 is formed to be larger than the width of the box guide 45 , and the inner packing box among the bottom surfaces of the refrigerant box 32 . A hole 34 may be formed in the bottom surface not covered by 44 and the box guide 45 .

In addition, according to the present embodiment, due to the stacked structure of the inner packaging box 44 and the refrigerant box 32 surrounded by the box guide 45, which have different widths, the box guide 45 and the body portion 11 ) between the additional refrigerant arrangement area 35 may be defined.

A refrigerant including dry ice may be disposed in the additional refrigerant arrangement area 35 , so that, according to this embodiment, cold air provided from the dry ice disposed in the refrigerant box 32 is formed in one or more holes 34 in the bottom surface. A stronger cooling effect can be secured as cold air is additionally provided from the additional dry ice disposed in the additional refrigerant arrangement area 35 while directly reaching the side surfaces of the box guide 45 through the .

9e to 9i are views showing embodiments of box guides usable for a cold chain medicine transport container according to various embodiments of the present invention.

Referring to Figure 9e, the box guide 45 may be formed to surround four sides of the inner packaging box 44 disposed therein, the material of which is corrugated cardboard, plastic, etc., the inner packaging box 44, the body portion If it is stably fixed to (11) and the refrigerant box 32 can be stacked thereon, it can be formed in any structure of any material.

9F to 9I , the box guides 46a to 46d may be formed in a hollow rectangular parallelepiped structure formed to correspond to one surface of the inner packaging box 44 . For example, the four box guides 46a may be formed to correspond to the four surfaces of the inner packaging box 44 , respectively, and may be formed between the body portion 11 and the inner packaging box 44 .

As shown in Fig. 9f, the box guide 46a may be manufactured so that no other fastening structure is displayed on its surface, and as shown in Fig. 9g, the box guide 46b is 3 formed side by side in one direction. It may be manufactured to have a fastening structure including four protrusions, and as shown in FIG. 9H , the box guide 46c may be manufactured to have a fastening structure including three protrusions formed side by side alternately in both directions, , as shown in FIG. 9i , the box guide 46d includes three protrusions formed side by side in one direction, and may be manufactured so that the position of the fastening structure is formed on the corner side.

The box guides 46a to 46d of FIGS. 9f to 9i also stably fix the inner packaging box 44 such as corrugated cardboard or plastic to the body 11, and the refrigerant box 32 is laminated thereon If possible, it may be formed in any structure of any material. In addition, four box guides may be arranged in only one type of the box guides 46a to 46d of FIGS. 9f to 9i inside the container. Alternatively, the box guides 46a to 46d of FIGS. 9f to 9i inside the container. Four box guides made of several types (eg, two box guides 46b and two box guides 46c) may be arranged.

10 is a view showing the corner guide portion of the cold chain medicine transport container according to an embodiment of the present invention.

Referring to FIG. 10 , a guide part 151 may be formed at the edge of the cold chain medicine transport container. (a) is a perspective view of a drug transport container for cold chain, (b) and (c) are top views of the cold chain drug transport container with the lid open.

The guide unit 151 may provide stability not only to protect the inside of the medicine transport container for the cold chain, but also not to collapse when stacking, loading, storing or transporting the medicine transport container for the cold chain. In order to provide stability in loading, the guide part 151 formed on the cover part 21 side of the medicine transport container for the cold chain is arranged to fit the size of the bottom surface of the medicine transport container for the cold chain, and when loading, the cold chain It is possible to ensure that the drug transport containers can be stably supported with each other. In this embodiment, the guide part 151 may be made of a plastic material, but the scope of the present invention is not limited thereto.

11 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 11 , a medicine transport container 5 for a cold chain according to an embodiment of the present invention includes a body portion 11 in which medicines are accommodated, body heat insulating materials 13a, 13b, 13c, and an additional body portion 19 . , may include an outer box 15 and a cover portion 21 .

The difference from the medicine transport container 1 for cold chain is that it further comprises an additional body portion 19 disposed between the body heat insulating material 13a, 13b, 13c and the outer box 15 . The additional body 19 may be made of expanded polypropylene. In particular, the additional body portion 19 may be formed to surround the outer surface of the body heat insulating material (13a, 13b, 13c).

Accordingly, the body portion 11 and the additional body portion 19 are formed to surround the six surfaces of the body heat insulating materials 13a, 13b, 13c, so that not only the effects described with reference to FIG. 1 but also additional insulation performance and body Insulation protection effect can be obtained.

Since the above description with reference to FIG. 1 may be applied to other features except for the above differences, a redundant description will be omitted herein.

12 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

12 , the cold chain medicine transport container 6 according to an embodiment of the present invention further includes an additional heat insulating material 17 disposed on the outer surface of the body heat insulating material 13a, 13b, 13c. It has a difference from the medicine transport container (5) for the cold chain.

For other features except for further comprising an additional body portion 19 made of expanded polypropylene material, the description described above in relation to FIG. 6 may be applied, and thus redundant description will be omitted here.

Of course, as in FIG. 6 , the additional heat insulating material 17 may be disposed on the inner surface of the body heat insulating material 13a , 13b , 13c . That is, the additional heat insulating material 17 is different from that shown in FIG. 13 , between the body part 11 and the body heat insulating materials 13a, 13b, 13c, that is, the outer surface of the body part 11 and the body heat insulating materials 13a, 13b, 13c. ) may be disposed between the inner surfaces of the

In addition, if the additional heat insulator 17 is formed of a plurality of plate-shaped vacuum insulators, some of the plurality of plate-shaped vacuum insulators are disposed on the outer surfaces of the body insulators 13a, 13b, and 13c, and the other part is the body insulator 13a , 13b, 13c) may be disposed on the inner surface.

13 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to Figure 13, the cold chain medicine transport container 7 according to an embodiment of the present invention, the body heat insulating material (13b) disposed on the outer surface of the lower wall of the body heat insulating material (13a, 13b, 13c) It differs from the cold chain medicine transport container 5 in that the thickness is formed to be thicker than the thickness of the body heat insulating materials 13a and 13c disposed on the outer surfaces of the plurality of sidewalls.

For other features except for the fact that the additional body portion 19 made of expanded polypropylene material is further included, the description described above in relation to FIG. 7 may be applied, and thus the redundant description will be omitted here.

14 is a view showing a cross-section of a medicine transport container for a cold chain according to an embodiment of the present invention.

Referring to FIG. 14 , the cold chain medicine transport container 8 includes a refrigerant box 32 disposed in a partial space inside the body 11 , and the inner space 42 is inside the body 11 . It is different from the medicine transport container 5 for the cold chain in that it is defined in another part of the space.

For other features except for further comprising an additional body portion 19 made of expanded polypropylene material, the description described above with respect to FIGS. 8 to 9I may be applied, and thus the redundant description will be omitted here.

15 is a cross-sectional view of a medicine transport container for a cold chain according to an embodiment of the present invention, and FIG. 16 is an exploded view showing a medicine transport container for a cold chain according to an embodiment of the present invention.

15 and 16, when the additional body portion 19 is made of polypropylene foam, the design of the cold chain medicine transport container may vary. For example, as shown in Fig. 15, the body portion 11, the additional body portion 19 of the expanded polypropylene material and the cover portion 21 may be designed in a structure that engages each other at one point, but this The scope of the invention is not limited thereto, and various modifications are possible according to the purpose of implementation.

For another example, as shown in FIG. 16 , the cover part 21 having a foaming ratio of 10 times, the cap part 25 having a foaming ratio of 10 times, the body part 11 having a foaming ratio of 30 times, and the foaming ratio It may be designed as an additional body portion 19 made of expanded polypropylene material formed 10 times, the cover portion 21 having an expansion ratio of 18 times, the body portion 11 having a foaming ratio of 30 times, and the expansion ratio of 18 times. It can also be designed with an additional body portion 19 of the formed expanded polypropylene material. That is, at least some of the cover part 21 , the cap part 25 , the body part 11 and the additional body part 19 may be manufactured to have different expansion ratios, and as the expansion ratio is precisely adjusted, the Colt The purpose of improving the thermal insulation performance of the chain medicine transport container and reducing the weight can be achieved at the same time.

Of course, the cold chain medicine transport container shown in FIGS. 15 and 16 is merely exemplary, and specific designs such as expansion ratio, thickness, and configuration may be changed according to the purpose of implementation.

Hereinafter, the present invention will be further described by describing embodiments of the present invention, and the scope of the present invention is not limited thereto.

[Example 1]

In order to investigate the insulation performance of the medicine transport container for cold chain according to the present invention, this time using the simulation program "virtual cold chain", the thickness of VIP and EPP was set to 30 mm, and only the arrangement order of EPP and VIP was changed. and other conditions were set the same. Environmental conditions were measured under the most severe conditions with the ISTA 7D 72hrs summer profile, and the location of the thermocouple was set at the inner center of the vessel. And the target temperature was set to 2 °C to 8 °C, which is a general refrigeration temperature condition.

The results are shown in FIGS. 17 and 18 . 17 corresponds to a container in which the VIP is disposed outside the EPP, and FIG. 18 corresponds to a container in which the VIP is disposed inside the EPP. In both cases, it was possible to maintain the target temperature beyond 120 hours, which is the maximum transport time of a pharmaceutical container in general.

Then, both containers were subjected to a thermal load test using the KS A 1712 test method for small refrigerators for delivery to measure the amount of power consumption per internal surface area. As a result, the value is 19.8 W/m ² (lowest value 19.8 W/m ² , average 22.8 W/m ² ) for the vessel in which the VIP is placed outside the EPP, and for the vessel in which the VIP is placed inside the EPP, With 29.0 W/m ² (lowest value 29.0 W/m ² , average 29.9 W/m ² ), it was found that the thermal insulation performance of the vessel in which the VIP was disposed outside the EPP was better.

[Example 2]

The amount of power consumption per internal surface area of a medical disposable container of another company, a container for fresh food, Styrofoam, and a medicine transport container for cold chain according to an embodiment of the present invention was compared. In the case of the medicine transport container for the cold chain of the present invention used in this example, the thickness of the VIP was set to 20 mm. Meanwhile, other companies' medical disposable containers are made of paper and 40 mm thick VIP, their fresh food containers are made of polypropylene and about 3 mm thick VIP, and Styrofoam containers do not contain VIP. In addition, in order to examine the effect of the airtightness provided by the structure of the EPP body of the present invention, power consumption per internal surface area of the container excluding VIP in the cold chain medicine transport container of the present invention was also measured.

As can be seen from the above results, the cold chain medicine transport container according to an embodiment of the present invention exhibited an excellent thermal insulation effect due to a small thermal load compared to the conventional container of other companies. Specifically, the medicine transport container for cold chain according to the present invention provided about 3 times superior thermal insulation effect compared to general fresh food containers and about 5 times better than Styrofoam.

In addition, as can be seen from the result of excluding VIP from the container of the present invention, the thermal insulation performance is improved due to the airtightness of the EPP structure of the container according to the present invention. Here, it was confirmed that the performance was improved by more than 30% by including the VIP.

[Example 3]

An experiment was performed to confirm the effect according to the thickness of the VIP that can be used in the present invention, and to find a suitable thickness of the VIP. The simulation program "virtual cold chain" was used, and the test conditions were conducted under the summer conditions of ISTA 7D 72 hours. Specifically, one cycle was 22 °C for 4 hours, 35 °C for 6 hours, 30 °C for 56 hours, and 35 °C for 6 hours. The target temperature range was 2 ℃ to 8 ℃, and conditions other than the thickness of the VIP were unified.

The experimental results are shown in FIGS. 19 and 20 . As shown in FIGS. 19 and 20 , the insulation performance increased as the thickness increased, but the best insulation performance was recorded at 25 mm, and the performance was maintained at 30 mm. In the summer condition of 72 hours, which is the most severe condition of the ISTA 7D profile, performance over 80 hours at 3 mm~30 mm thickness and over 120 hours at 10 mm~30 mm thickness were shown. Among them, it provided the most desirable results around 25 mm, which shows the highest performance with the minimum thickness, and was not suitable for the working environment because it was heavy at a VIP of 40 mm or more.

[Example 4]

An experiment was conducted to compare the sublimation rate of dry ice depending on whether or not the VIP was placed on the outside of the EPP body. In Examples and Comparative Examples, the EPP body part was manufactured to have the same size and the same expansion ratio, and the thickness of the side wall of the EPP body part was designed to be 25 mm, and the thickness of the lower wall of the EPP body part was designed to be 30 mm. And, the thickness of the VIP arranged to correspond to the side wall of the EPP body was designed to be 25 mm, and the thickness of the VIP arranged to correspond to the lower wall of the EPP body was designed to be 30 mm.

"test 1" shows the experimental results for a container (Example) formed so that an outer box surrounds the VIP after the VIP is placed outside the EPP body, "test 2" is the VIP is not placed outside the EPP body Shows the experimental results for a container (comparative example) formed so that the outer box wraps the EPP body without being unopened.

In a laboratory environment at room temperature, 3 kg of dry ice was put into containers corresponding to Examples and Comparative Examples, and the sublimation rates of dry ice were compared at regular time intervals.

As can be seen from FIG. 21 , in the case of the comparative example, the sublimation of dry ice occurred at a rate of about three times or more faster than that of the example. From this, it was possible to confirm the insulation effect due to the VIP disposed on the outside of the EPP body.

23 and 24 are graphs for explaining the thermal insulation performance of the cold chain medicine transport container to which the refrigerant box according to an embodiment of the present invention is applied.

Specifically, FIG. 23 shows the temperature maintenance result of the medicine transport container for cold chain when dry ice is filled in both the refrigerant box 32 and the additional refrigerant arrangement area 35 in FIG. 9D, and FIG. In 9d, when dry ice is filled only in the refrigerant box 32 and not in the additional refrigerant arrangement area 35, the temperature maintenance result of the medicine transport container for the cold chain is shown.

23 and 24 , as a result of performing a test according to the ISTA 7D Summer profile, both of them showed an excellent static temperature maintenance effect and a cooling effect. ), the static temperature maintenance effect and the cooling effect were the best when all of them were filled, and even when dry ice was filled only in the refrigerant box 32 and not in the additional refrigerant arrangement area 35 It was possible to move cold air through the formed hole, which showed a relatively good effect.

That is, by forming a hole formed in the bottom surface of the refrigerant box 32 , it is possible to maintain a constant temperature for a long time with only a small amount of dry ice, and the effect is further maximized when the refrigerant is additionally arranged in the additional refrigerant arrangement area 35 . it can be seen that

25 to 27 are graphs for explaining the thermal insulation performance of a cold chain medicine transport container when dry ice is used as a refrigerant and PCM is used according to an embodiment of the present invention.

Specifically, FIG. 25 is a test result under repeated environmental conditions of ISTA 7D Summer 24 profile as a dry ice application container, FIG. 26 is a test result under repeated environmental conditions of ISTA 7D 24 Winter 24 profile as a PCM application container, and FIG. This is the test result under repeated environmental conditions of ISTA 7D 24 Summer 24 profile as a PCM application container.

25 to 27, the dry ice application container exhibited an effect of maintaining a constant temperature for about 140 hours between about -70 ° C. and about -80 ° C., and in the PCM application container, about 2 ° C. to about 2 ° C. in both winter and summer environments. It exhibited the effect of maintaining a constant temperature for about 140 hours between about 8 °C.

Although embodiments and examples of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and in the technical field to which the present invention belongs, using the basic concept of the present invention defined in the following claims Various modifications and improvements by those of ordinary skill in the art also fall within the scope of the present invention.

Claims (20)

a lower wall (bottom wall) and a plurality of side walls extending in an upward direction from the lower wall are integrally formed to define an inner space, and a body portion formed of expanded polypropylene;
a body heat insulating material disposed on an outer surface of the lower wall and an outer surface of the plurality of side walls;
an additional heat insulating material disposed on the outer surface or inner surface of the body heat insulating material;
an outer box disposed outside the body insulation material and the additional insulation material;
a cover part covering the upper part of the body part; and
containing refrigerant;
The body insulation is formed of a plurality of plate-shaped vacuum insulation materials, and the additional insulation is formed of a single three-dimensional structure-type vacuum insulation material folded to have a three-dimensional structure,
The body heat insulating material and the refrigerant are separated based on the body part,
Medicine transport container for cold chain. According to claim 1,
The outer box is made of plastic or paper,
The outer box is formed to surround the outer surface of the body portion, the body heat insulating material and the cover portion, cold chain medicine transport container. According to claim 1,
Between the body heat insulating material and the outer box, further comprising an additional body portion formed to surround the outer surface of the body heat insulating material,
The additional body portion is made of expanded polypropylene material, a cold chain medicine transport container. 4. The method of claim 3,
The expansion ratio of the cover part and the additional body part and the expansion ratio of the body part are different from each other, a medicine transport container for a cold chain. 5. The method of claim 4,
The expansion ratio of the cover part and the additional body part is 10 times or 18 times, and the expansion ratio of the body part is 30 times, a cold chain medicine transport container. According to claim 1,
The thickness of the body insulating material is 10 mm to 30 mm, the thickness of the additional insulating material is 3 mm to 10 mm, cold chain medicine transport container. delete delete According to claim 1,
The thickness of the body insulation material disposed on the outer surface of the lower wall of the body insulation material is thicker than the thickness of the body insulation material disposed on the outer surface of the plurality of side walls, cold chain medicine transport container. According to claim 1,
The cover portion accommodates a cover insulation material therein, and includes a cap portion disposed to cover the cover insulation material, cold chain medicine transport container. 11. The method of claim 10,
The cover insulation is a vacuum insulation material, cold chain medicine transport container. 12. The method of claim 11,
The thickness of the cover insulation is 3 mm to 30 mm, cold chain medicine transport container. According to claim 1,
wherein the refrigerant is a plurality of phase changing materials (PCMs) disposed on an inner surface of the lower wall and an inner surface of the plurality of side walls;
The cross section of each of the plurality of PCM is a trapezoidal shape, cold chain medicine transport container. a lower wall (bottom wall) and a plurality of side walls extending in an upward direction from the lower wall are integrally formed to define an inner space, and a body portion formed of expanded polypropylene;
a body heat insulating material disposed on an outer surface of the lower wall and an outer surface of the plurality of side walls;
an outer box disposed outside the body heat insulating material;
a cover part covering the upper part of the body part;
a cap portion in which a cover insulation material is accommodated in the cover portion and disposed to cover the cover insulation material; and
containing refrigerant;
The body heat insulating material and the refrigerant are separated based on the body part,
The cover part includes a protrusion extending toward the inner space, a groove formed on the protrusion part of the cover part, and a protrusion formed on the cap part are fitted, the cover part and the cap part are coupled;
A medicine transport container for cold chain, wherein a groove formed on the concave portion of the cover portion and a protrusion formed on the protrusion portion of the body portion are fitted to couple the cover portion and the body portion. delete a lower wall (bottom wall) and a plurality of side walls extending in an upward direction from the lower wall are integrally formed to define an inner space, and a body portion formed of expanded polypropylene;
a body heat insulating material disposed on an outer surface of the lower wall and an outer surface of the plurality of side walls;
an outer box disposed outside the body heat insulating material;
a cover part covering the upper part of the body part;
a refrigerant including dry ice located in a refrigerant box disposed in a partial space inside the body part; and
an inner packaging box containing the product;
The body heat insulating material and the refrigerant are separated based on the body part,
The refrigerant box is stacked on the inner packaging box,
One or more holes are formed in the bottom surface not covered by the inner packaging box among the bottom surfaces of the refrigerant box,
Among the bottom surfaces of the refrigerant box, the hole is formed on the bottom surface between the side of the refrigerant box and the side of the inner packaging box, cold chain medicine transport container. 17. The method of claim 16,
The width of the refrigerant box is formed to be greater than the width of the inner packaging box,
An additional refrigerant arrangement area is defined between the inner packaging box and the body portion,
A medicine transport container for a cold chain, wherein dry ice is disposed in the additional refrigerant placement area. 17. The method of claim 16,
Further comprising a box guide formed to surround the inner packaging box,
The box guide is formed to be engaged to surround the four sides of the inner packaging box, the refrigerant box is laminated on the box guide, cold chain medicine transport container. 17. The method of claim 16,
The one or more holes are formed to extend long in a direction along a side edge of the inner packaging box, cold chain medicine transport container. a lower wall (bottom wall) and a plurality of side walls extending in an upward direction from the lower wall are integrally formed to define an inner space, and a body portion formed of expanded polypropylene;
a body heat insulating material disposed on an outer surface of the lower wall and an outer surface of the plurality of side walls;
an outer box disposed outside the body heat insulating material;
a cover part covering the upper part of the body part;
a refrigerant including dry ice located in a refrigerant box disposed in a partial space inside the body part;
an inner packing box containing the product; and
Comprising four box guides formed to surround the inner packaging box,
The body heat insulating material and the refrigerant are separated based on the body part,
The four box guides are each formed in a hollow rectangular parallelepiped structure to correspond to one side of the inner packing box, and are arranged to correspond to the four sides of the inner packing box, respectively,
The refrigerant box is disposed on the inner packaging box in the inner space of the four box guides arranged to correspond to the four sides, respectively, cold chain medicine transport container.

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