KR102333799B1 - Healing patch - Google Patents

Abstract

Disclosed is a healing patch which contains menthol, pyroligneous liquor, and oriental medicinal active ingredients inside a porous patch, which can deliver the oriental medicinal active ingredients to an attachment site, and which can absorb and remove human waste. The present invention provides the healing patch comprising: a porous outer skin; porous powder contained in the porous outer skin to absorb human waste; an active ingredient contained in the porous outer skin; an adhesive auxiliary layer attached to one side of the porous outer skin and having an adhesive surface on the other side; and a protective film attached to the other side of the adhesive auxiliary layer and protecting the adhesive surface and the other side of the porous outer skin.

Description

Healing patch {Healing patch}

The present invention relates to a healing patch, and more particularly, it contains menthol, wood vinegar, and oriental medicinal active ingredients inside a porous patch, which can deliver oriental active ingredients to the attachment site, and can absorb and remove human wastes It's about healing patches.

The skin is essential for maintaining human health and life. It not only has endocrine function, immune function, absorption and secretion function, and protective function, but also functions as a waterproofing and antibacterial by secreting sweat, sebum and waste to regulate body temperature and maintain the acidity of the subsurface. It plays an important role in performing a wide variety of functions, such as water control, respiratory function, vitamin D synthesis function, and nutrient storage function.

In addition, human skin performs various functions such as body protection, temperature regulation, perception, absorption, secretion, and emotion transmission, and the human skin undergoes changes over time by various internal and external factors.

That is, internally, the secretion of various hormones that control metabolism is reduced, the function and activity of immune cells is lowered, so that the biosynthesis of immune proteins and biological constituent proteins necessary for the living body is reduced, and externally, due to the destruction of the ozone layer, Due to the increase in the ultraviolet content of the sun's rays and the deepening of environmental pollution, free radicals and free radicals and free radicals increase as a result, overall skin wrinkles increase, skin elasticity decreases, spots, freckles and age spots increase, etc. will cause several changes in In particular, the aging process of the skin occurs due to the loss of elasticity and flexibility of the skin, a decrease in the amount of moisture in the skin, a decrease in the skin regeneration ability, and the like.

Therefore, a lot of research is being conducted on methods and materials that can prevent and improve such damage and aging of the skin. A lot of research has been conducted on transdermally absorbable formulations.

As such formulations, for example, cosmetic packs or mask packs, cataplasma, pars, aerosols, lotions, ointments, creams and liquids are used. Formulations in the form of patches attached to the skin are frequently used.

However, in the conventional patch formulation, when applied to the skin, etc., the active ingredient carried in the patch does not dissolve quickly, and there is a problem in that adhesion to the skin is deteriorated. Accordingly, a patch including an adhesive component was used to improve adhesion to the skin, but in this case, since an adhesive component close to water-soluble is used as it is, there may be a problem in stabilization of the active ingredients included in the patch.

On the other hand, wood vinegar is an aqueous solution obtained by condensing white gas generated by thermal decomposition as a sap extracted when trees are carbonized. Wood vinegar is mixed with starch and powdered (hereinafter referred to as wood vinegar powder) to make a patch, and is used to remove water poison. These wood vinegar patches are mainly attached to the soles of the feet where the blood of the whole body is gathered, and are used by attaching them to various parts such as knees and shoulders depending on the purpose.

In the early stages of development, the wood vinegar patch was manufactured by mixing wood vinegar and starch, but gradually, products with various functional ingredients such as chitosan and jade are being developed.

However, most of the conventional wood vinegar patches simply absorb the wood vinegar components into the human body, so their adhesive strength and utility are poor. This is a slightly added degree, so it is necessary to have more diverse functions to exert a synergistic effect with each other and to improve the effect of the patch itself.

(0001) Republic of Korea Patent No. 10-1440318 (0002) Republic of Korea Patent Registration No. 10-0961775

The present invention has been devised to solve the above problems, and an object of the present invention is to improve the porous outer shell used on the surface of the patch to provide a healing patch capable of absorbing wastes from the body while increasing the effective ingredient delivery effect will do

Another object of the present invention is to provide a healing patch that can give a refreshing feeling to the human body by appropriately mixing wood vinegar, menthol and other oriental medicinal ingredients, while removing wastes from the human body and delivering oriental medicinal ingredients.

The problems of the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

In order to solve the above problems, the present invention provides a porous shell; a porous powder contained in the porous shell to absorb human wastes; an active ingredient contained in the porous shell; an adhesive auxiliary layer attached to one side of the porous shell and having an adhesive surface on the other side; and a protective film attached to the other side of the adhesive auxiliary layer and protecting the adhesive surface and the other side of the porous outer shell.

In one embodiment, the porous shell is made of a semipermeable membrane having micropores having a size of 0.05 to 1 μm by stretching a fluororesin on one side, and a mesh, woven fabric, knitted fabric or nonwoven fabric having a porous structure on the other side, , The space between the porous shell is separated into 2 to 100 loading spaces by an impermeable dividing film connecting one side and the other side of the porous shell, and the loading space selectively contains the porous powder or the active ingredient and 10 to 20 parts by weight of diatomaceous earth powder having an average particle size of 0.1 to 10 μm; 50 to 80 parts by weight of activated carbon powder having an average particle size of 5 to 20 μm; 20-30 parts by weight of sodium hydrogen carbonate; and 20 to 30 parts by weight of desulfurized gypsum powder having an average particle size of 1 to 20 μm, and the active ingredient includes wood vinegar powder, herbal medicine powder and microcapsules, and the microcapsules are nanoparticles in a solvent in which menthol is dissolved. mixing to prepare a nanoparticle complex solution; emulsifying the nanoparticle complex solution by mixing it with a temperature-dependent oil; and injecting the emulsified solution into the coating solvent in which the coating material is dissolved, and treating the nanoparticle complex solution to be coated on the coating material and encapsulated into fine particles, wherein the nanoparticles are Gold, silver, copper, titanium, selenium, magnesium, iron, vanadium, platinum, or an organic compound thereof, and the microcapsule has a film of 1 to 10 nm, and as the porous outer shell is pressed, the film is destroyed, Wood vinegar powder, charging the wood into the heating furnace; After replacing the inside of the heating furnace with an inert gas, heating the heating furnace to a temperature of 200 ~ 500 ℃; collecting the liquid material by collecting and cooling the gas generated in the upper part of the heating furnace; allowing the liquid material to stand for 1 to 20 days to phase-separate it into an oily component, an aqueous component, and a precipitate; removing methanol by separating and re-distilling an aqueous component after the phase separation is completed; Filtering the aqueous component from which the methanol has been removed with activated carbon to prepare a wood vinegar; and mixing 10-50 parts by weight of wood vinegar based on 100 parts by weight of starch, then drying and pulverizing to prepare wood vinegar powder; Jongyong, Pagukcheon, Baekbokshin, Sanjoin, Wonji, Hyangbuja, Seokchangpo, Sign, Gardenia, Jinpi, Mokhyang, Shiho, Cheongung, Angelica, Gobon, Windbreak, Ginseng, Earthquake, Yukjongyong, Cheoncho, Shinihwa, Joyeop, Mint, Ayeop, Baeksil, Washing one or more medicinal materials selected from biryeom, mussel, betel nut, gwakhyang, sansa, banseok, health, white paper, and gilgyeong, and then pulverizing it to a size of 0.1-5 mm; And it is prepared by a method comprising the step of charging the pulverized medicine into the expander and then heating it to a pressure of 1 to 3 Mpa and a temperature of 100 to 300 ° C. to expand, wherein the adhesive auxiliary layer is horizontally stretchable thermoplastic polyurethane preparing the film; and coating an adhesive on the upper and lower surfaces of the polyurethane film, wherein the adhesive is mixed with 0.2 to 0.5 parts by weight of a peptizing agent and 650 to 700 parts by weight of toluene with respect to 100 parts by weight of natural rubber and stirring at 70 to 90° C. for 8 to 12 hours to prepare a peptized rubber solution; preparing a mixed solution by adding 20 to 40 parts by weight of styrene-isoprene-styrene rubber and 80 to 120 parts by weight of a tackifier to the peptized rubber solution; It may be prepared by a method comprising the step of preparing a pressure-sensitive adhesive by adding and mixing 1 to 5 parts by weight of polymer beads to the mixed solution.

According to an embodiment of the present invention, it is possible to provide a healing patch capable of absorbing wastes of the human body while improving the effective ingredient delivery effect by improving the porous shell used on the surface of the patch.

In addition, the present invention can provide a healing patch that can give a refreshing feeling to the human body by appropriately mixing wood vinegar, menthol and other oriental medicinal active ingredients, while removing the human body's wastes, and throwing oriental medicinal active ingredients.

The effect according to the present invention is not limited by the contents exemplified above, and more various effects are included in the present invention.

1 shows the front (a) and back (b) of the healing patch according to an embodiment of the present invention.
Figure 2 shows the internal shape of the porous shell according to an embodiment of the present invention.
Figure 3 shows the structure of the adhesion auxiliary layer according to an embodiment of the present invention.
4 is an enlarged view showing the structure of the adhesion auxiliary layer including the polymer bead according to an embodiment of the present invention.
5 schematically shows the behavior of the polymer bead when the adhesion auxiliary layer is stretched according to an embodiment of the present invention.
6 shows a commercialized healing patch according to an embodiment of the present invention.

Hereinafter, various embodiments will be described in more detail with reference to the accompanying drawings. The embodiments described herein may be variously modified. Certain embodiments may be depicted in the drawings and described in detail in the detailed description. However, the specific embodiments disclosed in the accompanying drawings are only for easy understanding of various embodiments. Therefore, the technical spirit is not limited by the specific embodiments disclosed in the accompanying drawings, and it should be understood to include all equivalents or substitutes included in the spirit and scope of the invention.

Terms including an ordinal number, such as first, second, etc., may be used to describe various elements, but these elements are not limited by the above-described terms. The above terminology is used only for the purpose of distinguishing one component from another component.

In this specification, terms such as "comprises" or "have" are intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, but one or more other features It should be understood that this does not preclude the existence or addition of numbers, steps, operations, components, parts, or combinations thereof. When a component is referred to as being “connected” or “connected” to another component, it is understood that the other component may be directly connected or connected to the other component, but other components may exist in between. it should be On the other hand, when it is said that a certain element is "directly connected" or "directly connected" to another element, it should be understood that no other element is present in the middle.

Meanwhile, as used herein, a “module” or “unit” for a component performs at least one function or operation. And “module” or “unit” may perform a function or operation by hardware, software, or a combination of hardware and software. In addition, a plurality of “modules” or a plurality of “units” other than a “module” or “unit” that must be performed in specific hardware or are executed in at least one processor may be integrated into at least one module. The singular expression includes the plural expression unless the context clearly dictates otherwise.

In addition, in describing the present invention, when it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be abbreviated or omitted.

Figure 1 shows the structure of the healing patch of the present invention, Figure 6 is a photograph showing the actually manufactured healing patch.

The present invention relates to a porous shell; a porous powder contained in the porous shell to absorb human wastes; an active ingredient contained in the porous shell; an adhesive auxiliary layer attached to one side of the porous shell and having an adhesive surface on the other side; And it is attached to the other side of the adhesive auxiliary layer, it relates to a healing patch comprising a protective film for protecting the adhesive surface and the other side of the porous shell.

In the case of the existing patch-type drug delivery system, the drug-impregnated porous delivery part is simply attached to the skin and used, but in this case, the delivery time is short and the duration of use is ? It is difficult to convey. In addition, in the case of an adhesive for attaching the patch to the human body, it not only interferes with the drug delivery, but may also damage the skin during detachment, so it is used only limitedly.

Accordingly, the present invention is prepared to contain the active ingredient in the porous shell and release it for a certain period of time. It is possible to provide a healing patch that can be safely removed even when removed.

The porous shell 100 is a part containing a porous powder and an active ingredient therein, and can be used as a passage for absorbing wastes of the human body and delivering the active ingredient to the human body.

To this end, the porous shell 100 is made of a semipermeable membrane 110 having micropores having a size of 0.05 to 1 μm by stretching a fluororesin on one side, and a mesh, woven fabric, knitted fabric or nonwoven fabric having a porous structure on the other side. may be manufactured (120).

One side 110 of the porous shell is the opposite part that does not come into contact with the human body, and part or all of it is a side adhered to the adhesive auxiliary layer 200 to be described later. However, one side 110 of the porous shell may be made of a semi-permeable membrane having micropores formed therein to release moisture adsorbed to the porous powder, which will be described later. This can facilitate the release of moisture.

In this case, the semipermeable membrane used is preferably formed with micropores having a size of 0.05 to 1 μm by stretching a fluororesin. Due to this semi-permeable membrane, the active ingredients and porous powder injected into the space formed by the porous shell cannot be released to the outside, but sweat in the form of water vapor supplied from the human body and moisture evaporated from the porous powder can be released to the outside, which When the space formed by the porous shell is subjected to pressure according to the movement of the human body, it may be accelerated. At this time, when the micropores of the semipermeable membrane have a size of less than 0.05 μm, the moisture exchange as described above does not occur. can be

The inside of the porous shell 100 may be filled with the porous powder 140 and the active ingredient 150 . However, since the de-copolymer powder has an effect of adsorbing the material eluted from the active ingredient, it is preferable to separate it and fill it in each space.

To this end, the space between the porous shell is divided into 2 to 100 loading spaces by an impermeable dividing film 130 connecting one side and the other side of the porous shell, and the loading space is the porous powder or the active ingredient. may optionally be included.

The space between the porous shells may be divided by the impermeable dividing film 130 . The impermeable dividing film 130 used at this time can be used without limitation as long as it is a film that does not pass the porous powder 140, the active ingredient 150, and moisture, preferably polyethylene, polypropylene, polyethylene terephthalate, poly It may be a film made of vinyl chloride, polycarbonate or polylactic acid.

The impermeable film 130 may divide the space between the porous shells into 2 to 100 loading spaces (see FIG. 2 ). To this end, the impermeable dividing film 130 may be manufactured in a form that connects one side 110 and the other side 120 of the outer shell, and the film is connected horizontally and vertically to form a side surface of the loading space. have. That is, the loading space may be a space in which the side is composed of the impermeable dividing film, and one side and the other side are composed of the porous shell. At this time, when the loading space is less than two, the porous powder and the active ingredient may be mixed, and when more than 100 are installed, the volume occupied by the film increases, which may be inefficient.

The porous powder 140 or the active ingredient 150 may be selectively loaded in the loading space formed as described above. As described above, since the porous powder can be used as a physical adsorbent, the component eluted from the active ingredient can be adsorbed. In this case, the effect of the active ingredient eluted to the outside through the porous shell may be reduced, and the absorption efficiency of human wastes by the porous powder may also be reduced. Therefore, it is preferable to inject only one of the porous powder or the active ingredient into the loading space formed by the impermeable dividing film into each space. Through this, the porous powder and the active ingredient can be spatially separated, and a decrease in adsorption efficiency due to mixing can be minimized.

The other side 120 of the porous shell is a part in contact with the human body and is made of a porous material so that the product eluted from the active ingredient is delivered to the human body and waste products emitted from the human body can be adsorbed to the porous powder. can transmit To this end, the other side of the porous outer shell may be made of a mesh, woven fabric, knitted fabric, or nonwoven fabric, and preferably a mesh layer for protecting the nonwoven fabric fibers is combined on the surface of the nonwoven fabric having a thickness of 0.1 to 1 mm. have. At this time, if the nonwoven layer has a thickness of less than 0.1mm, the durability of the nonwoven layer may be reduced. can

The porous powder 140 is filled in the space between the porous shells in order to absorb impurities emitted from the human body. can

To this end, the porous powder 140 includes 10 to 20 parts by weight of diatomaceous earth powder having an average particle size of 0.1 to 10 μm; 50 to 80 parts by weight of activated carbon powder having an average particle size of 5 to 20 μm; 20-30 parts by weight of sodium hydrogen carbonate; and 20 to 30 parts by weight of desulfurized gypsum powder having an average particle size of 1 to 20 μm.

The diatomaceous earth refers to soil formed by the gathering of corpses of silicon, a single-celled organism, and has porosity and thus has excellent water absorption. In the case of the present invention, the diatomaceous earth can mainly adsorb moisture among impurities emitted from the human body. In the case of the diatomaceous earth, it may have a small effect within the average particle size, and if it is out of the average particle size, it may flow out of the outer shell or the adsorption efficiency may decrease when used.

The activated carbon maximizes micropores by applying steam to charcoal, and can be used to adsorb moisture and organic components generated in the human body. In particular, since activated carbon has many micropores as well as macropores, it can adsorb not only small-sized moisture but also high-molecular impurities, and thus can be used for adsorption of organic components. In the case of the activated carbon, if it has a size less than the particle size, it may leak to the outside of the porous shell and leave a black trace. efficiency may decrease.

The sodium bicarbonate itself is a porous material, and can mainly adsorb volatile substances among impurities emitted from the human body. The desulfurized gypsum may adsorb organic compounds including moisture.

The porous powder 140 is preferably added in combination as in the above ratio, and when it is out of the above range, the adsorption efficiency may be reduced.

The active ingredient 150 is a mixture of ingredients that elute beneficial ingredients to the human body, and may include wood vinegar powder, herbal medicine powder, and microcapsules.

The wood vinegar powder is prepared as a liquid by collecting the gas generated when the charcoal is dried and then cooling it, and may contain a large amount of volatile organic components including organic acids. This wood vinegar not only removes the dead skin cells of the human body due to the organic acid component, but also relaxes the keratin barrier on the surface of the human body to facilitate the discharge of wastes from the human body. However, since the existing wood vinegar is produced in a liquid form, it may be difficult to use it inside the porous shell as in the present invention, but in the present invention, it is preferable to use it after adsorbing it to starch and then powdering it by drying.

To this end, the wood vinegar powder is a step of charging wood into a heating furnace; After replacing the inside of the heating furnace with an inert gas, heating the heating furnace to a temperature of 200 ~ 500 ℃; collecting the liquid material by collecting and cooling the gas generated in the upper part of the heating furnace; allowing the liquid material to stand for 1 to 20 days to phase-separate it into an oily component, an aqueous component, and a precipitate; removing methanol by separating and re-distilling an aqueous component after the phase separation is completed; Filtering the aqueous component from which the methanol has been removed with activated carbon to prepare a wood vinegar; and mixing 10 to 50 parts by weight of wood vinegar based on 100 parts by weight of starch, followed by drying and pulverizing to prepare wood vinegar powder.

The heating furnace is used to carbonize the wood by supplying heat after charging the wood. When air, especially oxygen, is supplied, the wood is oxidized and ignited instead of being carbonized. It is preferable to do The inert key body used at this time may be nitrogen, helium, neon, argon, xenon, or carbon dioxide, and more preferably nitrogen or carbon dioxide. In the case of nitrogen, it is the main component of air and is an inert gas that can be used at a low price because it is produced as a by-product during the production of oxygen. It can be used as an inexpensive inert gas.

After replacing the inside of the heating furnace with an inert gas, it can be heated to a temperature of 200 ~ 500 ℃. Through this, the volatile substances contained in the wood can be evaporated and discharged, and even in the case of non-volatile substances, various volatile substances can be formed by being thermally decomposed by the supplied heat.

The volatile material formed as described above may be evaporated by heat and collected at the top of the heating furnace. At this time, the collected vapor preferably has a temperature of 80 ~ 150 ℃ in order to minimize the mixing of foreign substances and tar. If the temperature of the steam is less than 80 ℃, since the content of methanol may increase, it is preferable to discharge to the outside without collection, and the steam exceeding 150 ℃ may increase the content of tar upon cooling.

After the vapor collected as described above is cooled, it may be converted into a liquid material. Since the volatile material is evaporated and released due to the high temperature inside the heating furnace, it can be obtained by being liquefied when cooled. At this time, the cooling temperature is preferably 20 ~ 50 ℃.

The liquid material cooled as described above can be left standing for 1 to 20 days to phase-separate each component. The liquid material may contain an oily component, an aqueous component, and a precipitate. Among them, it is preferable to separate the sediment from the remaining oily substances, since the part that can be used as wood vinegar is the aqueous part. Various methods for phase separation can be used for this separation, but in the present invention, since each material corresponds to an immiscible material, when it is left for 1 to 20 days, the phases of each material are separated to easily obtain a desired aqueous material. can At this time, if the liquid material is left still for less than 1 day, phase separation of each material may be difficult, and if it is left standing for more than 20 days, it is uneconomical because a lot of time is required for phase separation.

After the phase separation is completed as described above, it is preferable to separate the aqueous material and then re-distill it. Although the aqueous material contains a component of wood vinegar, it may contain a substance that can harm the human body, such as methanol. In particular, since methanol can cause blindness in the human body, it is preferable to separate and remove it. However, in the case of methanol, since it can be separated by evaporation at around 65° C., it is preferable to separate the aqueous material by re-distillation.

It is desirable to filter the aqueous material from which methanol is separated as described above using activated carbon. Through this process, trace impurities contained in the aqueous material can be removed, and substances that can harm the human body can also be removed.

Since the wood vinegar prepared as described above is a liquid material, when applied to the healing patch of the present invention, it leaks out or is absorbed at a fast rate, making it difficult to achieve the purpose of the present invention. Therefore, it is preferable to use the powdered wood vinegar.

The wood vinegar may be mixed with starch. At this time, it is preferable to add 10 to 50 parts by weight of wood vinegar based on 100 parts by weight of the starch. Therefore, the drying process to be described later may not be possible.

Wood vinegar mixed with starch as described above may be dried and then pulverized to produce wood vinegar powder. At this time, it is preferable to use a reduced pressure drying or vacuum drying method in order to prevent the components of the wood vinegar from being thermally changed. In addition, since wood vinegar mixed with the starch may be agglomerated during the drying process, it is preferable to grind it after the drying is completed to produce wood vinegar powder of a certain size.

The herbal medicine powder is a powder obtained by pulverizing herbal medicines having an effect on waste discharge and fatigue recovery.

For this purpose, the herbal medicine powder is leaflet, gilgyeong, baekwa, eumyanggwak, ukjongyong, pagukcheon, baekbokshin, sanjoin, wonji, hyangbuja, seokchangpo, sine, gardenia, dermis, mokhyang, shiho, cheongung, angelica, gobon, windbreak, ginseng, ginseng After washing one or more medicinal materials selected from , yukjongyong, cheoncho, shinihwa, joyeop, mint, ayeop, baeksil, biryeom, wooseul, betel nut, gwakhyang, sansa, banseok, health, white paper, and gilgyeong, cut them into sizes of 0.1 to 5 mm. grinding; And it can be prepared by a method comprising the step of charging the pulverized medicine to the expander and then heated to a pressure of 1-3Mpa and a temperature of 100 ~ 300 ℃ bulging.

The pulverized herbal medicine may be used after being pulverized to a size of 0.1 to 5 mm and then expanded. The pulverized herbal medicines each have their own size, and if they have a large size, a feeling of foreign body may occur when included in the patch. Therefore, it is possible to control the dissolution rate of an appropriate active ingredient by pulverizing it to an appropriate size and using it, and it is possible to minimize the feeling of foreign body. At this time, when the pulverized herbal medicine is pulverized to a size of less than 0.1 mm, it may leak out of the porous shell, and when pulverized to a size exceeding 5 mm, a feeling of foreign body may be felt during use.

The pulverized herbal medicine pulverized as described above can be expanded by heating at a pressure of 1 to 3 Mpa and a temperature of 100 to 300 ° C. In the case of the pulverized herbal medicine, it may be properly eluted even when used in a pulverized state. It is possible to further facilitate the diffusion of the active ingredient by reducing its density to minimize the feeling of foreign body due to its weight and to expand it to have porosity.

The microcapsule contains a liquid material and menthol therein, and the liquid material can be supplied in the active ingredient, and thus the active ingredient can be eluted and delivered to the human body. That is, in the case of the present invention, only a solid material exists inside the porous shell before using the patch, and when attached to the human body for use, the microcapsule is destroyed by the movement of the human body or body temperature and the material inside is leaked. As a result, a liquid substance is supplied to the active ingredient so that the ingredient can be eluted. Accordingly, in the case of the present invention, it is possible to not only prevent the liquid substance from flowing out frequently and to be contaminated, but also to supply the active ingredient for a long period of time.

To this end, the microcapsule is prepared by mixing nanoparticles in a solvent in which menthol is dissolved to prepare a nanoparticle complex solution; emulsifying the nanoparticle complex solution by mixing it with a temperature-dependent oil; and injecting the emulsified solution into the coating solvent in which the coating material is dissolved, so that the nanoparticle complex solution is coated on the coating material and encapsulated into fine particles.

The microcapsule contains menthol and nanoparticles therein, and after attaching the patch to the body, when the user is active, the microcapsule presses the patch and is physically destroyed by this pressure, so the menthol and nanoparticles inside and the solvent may be discharged to the outside. Through this, a small amount of solvent can be supplied to the active ingredient, and by using this, the ingredient dissolved in the solvent can be supplied by human activity while keeping the active ingredient dry. In addition, in the case of the present invention, since volatile menthol is included in the microcapsule, when the patch is used, it can have an advantage of providing a refreshing feeling for a long time.

The menthol is a substance that gives a refreshing feeling to the human body by lowering the threshold of the cold spot of the human body, and allows the protein channel existing in the cold spot of the human body to be activated at a high temperature, so that you can feel cool even at a high temperature. In the case of the existing menthol, it was volatile, so only when the patch was attached, a feeling of cold could be felt, but the present invention; In this case, by mixing the menthol in the microcapsule, it is possible to continuously supply volatile menthol for a long period of time.

The nanoparticles are added to the inside of the microcapsule, and may flow out due to the destruction of the acid air microcapsule, and may serve to supply trace elements to inches. However, in order for the trace element to be absorbed into the human body, it needs to be reduced to a nano size, but in this case, it can be oxidized when it comes into contact with air. . In this case, the nanoparticles may include gold, silver, copper, titanium, selenium, magnesium, iron, vanadium, platinum, or an organic compound thereof.

The inside of the microcapsule may include 5 to 10 parts by weight of the nanoparticles relative to 100 parts by weight of the microcapsule. When the nanoparticles are included in less than 5 parts by weight, the effect of supplying trace elements by the nanoparticles may be reduced. As the cost increases, a catalytic effect by the leaked nanoparticles appears, and some of the active ingredients may be oxidized.

The menthol and the nanoparticles may be mixed and used in a solvent. this?? When the solvent flows out at the same time as dissolving the menthol, methanol, ethanol or water may be used as a material capable of dissolving the active ingredient, but water may be preferably used.

As described above, nanoparticles (nanoparticle complex solution) mixed with menthol and a solvent may be mixed with temperature-dependent oil by emulsification treatment. Through this, the nanoparticle complex solution can form a fine micelle structure in temperature-dependent oil, and it is possible to manufacture microcapsules by coating a film material on the surface of the micelle structure. In this case, the emulsification treatment is preferably performed by physically mixing the nanoparticle complex solution and the temperature-dependent oil to form a micellar structure.

The coating material may be added to a concentration of 1.5 wt% to 3.0 wt% with respect to the solvent of the coating solvent. When the film material is contained in less than 1.5 wt%, it may be difficult to create a film of the microcapsule, and when it is contained in a concentration exceeding 3.0 wt%, the film of the microcapsule becomes thick and the destruction of the microcapsule is performed according to the user's movement. it may not be

In addition, the coating solvent may be alcohol, more preferably ethanol.

Through this, the film of the microcapsule may have a thickness of 1 to 10 nm. When the film thickness of the microcapsule is less than 1 nm, since the microcapsule may be destroyed even by a small pressure, when the user moves, a large amount of microcapsules may be destroyed and the duration of the patch may be shortened, and the thickness exceeding 10 nm In the case of having , the menthol, nanoparticles and solvent may not flow out even by the movement of the human body.

The adhesive auxiliary layer 200 is a part used to fix the porous shell 100 to the surface of the human body, is manufactured in a film shape, and has an adhesive surface 220 on the other side, so that one side of the porous shell is the It can be attached to an adhesive surface. In addition, the adhesive auxiliary layer 200 is manufactured to be larger than the porous shell 100, and even after the porous shell is attached, a part of the adhesive surface may protrude outward, and the protruding part is attached to the human body. The other side of the porous shell may be tightly fixed to a part of the body (see FIGS. 1 and 6). In the case of an existing patch, an adhesive is applied to the other side of the outer skin, but this adhesive may block the movement of active ingredients and secretions secreted from the body, thereby reducing its effectiveness. However, in the present invention, an adhesive is not applied to the other side of the porous shell, and the porous shell is fixed to the human body by using an adhesive auxiliary layer made larger than the porous shell, so the prevention of material movement by the adhesive can be minimized. have.

The auxiliary adhesive layer 200 is prepared by a thermoplastic polyurethane film that can be stretched horizontally; and coating an adhesive on the upper and lower surfaces of the polyurethane film.

The step of preparing the polyurethane film may include mixing a polyol and an isocyanate, and then preparing a thermoplastic polyurethane film through uniaxial stretching; and pressing both sides of the film with a roller to form a groove in the same direction as the stretching direction.

Polyurethane has high malleability and ductility, and is chemically stable, so it can be used in the adhesion auxiliary layer as in the present invention. In addition, in the case of the present invention, a urethane-based pressure-sensitive adhesive is used for the pressure-sensitive adhesive, and since the adhesion between the urethane-based adhesive and the human body should be higher than the adhesion between the urethane-based adhesive and the human body, it is preferable to use the thermoplastic polyurethane to have a high affinity. do.

In this case, the polyol may be a polyether-based or polyester-based polyol, and the isocyanate may be an aromatic isocyanate, an aliphatic isocyanate, or a combination thereof.

The polyether-based polyol is a polyhydric alcohol such as sucrose, sorbitol, glycol, glycerol, or the like, or a compound having a divalent or higher active hydrogen, such as polyamine, as a starting material, and may be selected from copolymer polyols such as ethylene oxide and propylene oxide.

In addition, the polyester-based polyol is synthesized by using a polybasic acid and a polyalcohol having a hydroxyl group such as glycol and glycerol as a solvent, and the polyhydric alcohol is ethylene glycol, 1-4 butanediol, and 1,6-hexanediol. , polyethylene glycol, diethylene glycol, and the like, and the polybasic acid may be selected from aromatic base acids such as terephthalic acid, adipic acid, maleic acid, and succinic acid, aliphatic dibasic acids, and the like.

Aromatic isocyanate is diphenylmethane diisocyanate (4,4'-Diphenylmethnae diisocyanate, MDI), polymeric diphenylmethane diisocyanate (polymeric 4,4'-Diphenylmethnae diisocyanate, PMDI), toluene diisocyanate (TDI), 1 A compound containing -4 phenylene diisocyanate (1,4-phenylene diisocyanate, PPDI) and 1,5-naphthalene diisocyanate (1,5-Naphthalene diisocyanate, NDI) is an isocyanate having an aromatic ring.

Aliphatic isocyanate is 1,6-hexamethylene diisocyanate (1,6-Hexamethylene diisocyanate, HDI), isophorone diisocyanate (Isoporon diisocyanate, IPDI), dicyclohexylmethane-4,4'-diisocyanate (Dicyclohexylmethane-4, 4'-diisocyanate, H12MDI) may be used.

In addition, a catalyst may be further mixed in order to prepare the polyurethane. The catalyst is included in order to promote the crosslinking reaction between the polyol and the isocyanate, and may be used without limitation as long as it is a catalyst generally used in the manufacture of polyurethane. However, in order to increase the reactivity and improve physical properties, preferably, an amine-based catalyst and a trimerization catalyst may be mixed and used, and more preferably N,N-dimethylcyclohexylamine (N,N-dimethylcyclohexylamine), N,N, N',N'-pentamethyldiethylenetriamine (N,N,N',N'-pentamethyldiethylenetriamine), triethylenediamine, di-N-butyltindilaurylate, potassium acetate, lithium acetate, acetic acid Magnesium, an organotin compound, an organotitanium compound, or a combination thereof may be used.

In addition, in order to improve the physical properties of a foaming agent for foaming the polyurethane layer and the resulting polyurethane composite foaming agent, additives such as a foam stabilizer, a surfactant, a flame retardant, and a lubricant may be additionally included.

In particular, in the case of the foaming agent, the polyurethane is foamed to allow the adhesion auxiliary layer to have properties such as heat insulation and interlayer absorption, so if effects such as septum absorption and foreign matter additional absorption by the adhesion auxiliary layer are required, it can be used can

After mixing the polyol and the isocyanate as described above, it can be polymerized and produced into a film at the same time.

To this end, the step of preparing the thermoplastic polyurethane film may include mixing a polyol and an isocyanate, and then preparing a thermoplastic polyurethane film through uniaxial stretching; and pressing both sides of the film with a roller to form a groove in the same direction as the stretching direction.

In the case of the thermoplastic polyurethane, it is preferable to be prepared by stretching in the uniaxial direction. That is, the thermoplastic polyurethane may be stretched in the horizontal direction to be manufactured into a film, and through this, the thermoplastic polyurethane may have elasticity in the horizontal direction. In this case, the stretching may be manufactured using a stretching means for manufacturing a general film, and by passing a roller after the stretching, the surface may be processed smoothly and at the same time to have a uniform thickness.

In this case, the film is preferably prepared in an inert gas atmosphere. Since the polyol and isocyanate have high reactivity, they may be oxidized by contact with oxygen when left in the atmosphere. In order to prevent this, the production of the film is preferably performed in an inert gas atmosphere.

this?? The inert gas used is preferably nitrogen, helium, neon, argon or xenon, and more preferably nitrogen.

In the present invention, the term “atmosphere” means replacing the inside of the reactor or reaction space with a certain gas, and for example, the inert gas atmosphere means replacing the entire air inside the reactor with an inert gas.

In the thermoplastic polyurethane film prepared as described above, the adhesive surface may be compressed with a roller to form a groove. The groove is preferably formed in the same direction as the stretching direction, that is, in a horizontal direction.

The groove is a portion formed to control the adhesive force of the thermoplastic polyurethane film, and the adhesive force of the thermoplastic polyurethane film can be adjusted according to the shape and density of the groove, and an external force is applied to remove the thermoplastic polyurethane film. When applied, particularly when stretching in a horizontal direction, the adhesive auxiliary layer can be easily removed from the skin while the groove is deformed.

In the present invention, the term groove refers to depressions formed at regular intervals. In the present invention, valleys may be formed on the surface of the film at regular intervals so that the valleys and the protrusions are alternately positioned.

Looking at the grooves in detail, the grooves are formed by alternately repeating valleys and protrusions. In this case, the portion in contact with the human body corresponds to the protrusion, and by adjusting the shape of the protrusion, the contact area with the human body and the adhesive strength can be adjusted at the same time (refer to FIG. 3 ).

As an example, when the protrusion has the shape of a semicircle with a small diameter, the depth of the bone is also lowered, so that when the pressure is applied to attach the adhesive tape, it can be attached to the human body in a wide range, and as a result, the adhesive force will be strong. can

Conversely, in the case of having a semicircle with a large diameter, even if pressure is applied as the bone portion deepens, a portion of the bone may remain unattached, and thus it is possible to have a low adhesive force (see FIG. 8 ).

In addition, in order to further control the adhesive force, the protrusion may be manufactured in a shape constituting a part of an ellipse, and may be manufactured in a trapezoidal, rectangular, or triangular shape. That is, by controlling the shape and spacing of the protrusions, it is possible to adjust the adhesive strength even if the same adhesive is used.

In addition, the grooves may have a depth of 0.1 to 100 μm, and may be formed at intervals of 0.1 to 200 μm. When the groove has a depth of less than 0.1 μm, the adhesive force control by the groove may not appear, and if the groove has a depth exceeding 100 μm, the thickness of the film may be reduced and durability may be reduced, and the interval of less than 0.1 μm may be reduced. In the case of having, the durability of the adhesive tape may be deteriorated, and when the adhesive tape is formed at an interval exceeding 200 μm, the adhesive surface may be widened and thus control of the adhesive force may not appear.

After the thermoplastic polyurethane film is manufactured as described above, the adhesive 220 may be coated on the other side of the polyurethane film 210 .

The pressure-sensitive adhesive is prepared by mixing 0.2 to 0.5 parts by weight of a peptizing agent and 650 to 700 parts by weight of toluene with respect to 100 parts by weight of natural rubber and stirring at 70 to 90° C. for 8 to 12 hours to prepare a peptized rubber solution; preparing a mixed solution by adding 20 to 40 parts by weight of styrene-isoprene-styrene rubber and 80 to 120 parts by weight of a tackifier to the peptized rubber solution; It may be prepared by a method comprising the step of preparing a pressure-sensitive adhesive by adding and mixing 1 to 5 parts by weight of polymer beads to the mixed solution.

The natural rubber is a natural rubber extracted from a rubber tree, and in the present invention, the natural rubber is peptized to prepare a rubber solution, and then, a synthetic rubber, styrene-isoprene-styrene rubber, is mixed to prepare an adhesive. In the case of the natural rubber, since it contains various polymer components, the adhesive strength is excellent, and even when the adhesive is separated from the human body, it has a tendency to leave little residue. Also, since it is made of natural rubber, irritation to the human body can be minimized. However, it has weak durability and is easily decomposed by chemical components and human secretions. Conversely, the styrene-isoprene-styrene rubber has high chemical stability and durability, but when it is made of an adhesive, it tends to leave residues during separation. Therefore, in the case of the present invention, it is possible to provide an adhesive that can be neatly separated when separating the adhesive while having high durability and chemical stability by using a combination thereof in an optimal ratio.

The peptized rubber solution may be prepared by mixing 0.2 to 0.5 parts by weight of a peptizing agent and 650 to 700 parts by weight of toluene with respect to 100 parts by weight of natural rubber and stirring at 70 to 90° C. for 8 to 12 hours.

The peptizing agent is a component that can make rubber into a rubber solution by removing the crosslinking of the rubber polymer formed by crosslinking, and serves to reverse the step of preparing a solid rubber by injecting a crosslinking agent into the rubber solution during the manufacture of rubber. carry out The peptizing agent used at this time may be a general peptizing agent for natural rubber. In addition, the peptizing agent may reduce the viscosity of the pressure-sensitive adhesive so as to be easily sprayed and adhered to the surface of the film.

The peptizing agent may be added in an amount of 0.2 to 0.5 parts by weight based on 100 parts by weight of the natural rubber. When the amount of the peptizing agent is less than 0.2 parts by weight, the peptization of the natural rubber is not complete, so it may be difficult to mix with styrene-isoprene-styrene rubber, which will be described later, and when it exceeds 0.5 parts by weight, an adhesive prepared including the rubber The viscosity may be lowered, and the adhesive force may be reduced.

The toluene is used as a solvent for making the peptized rubber into a solution, and 650 to 700 parts by weight can be mixed with respect to 100 parts by weight of the cheoneon rubber. When the toluene is used in an amount of less than 650 parts by weight, the dissolution of the peptized rubber is not complete, and thus a defect may occur in the electrodeposition agent, and when it exceeds 700 parts by weight, the viscosity of the pressure-sensitive adhesive may be lowered.

The natural rubber mixed with the peptizing agent and toluene as described above may be prepared as a natural rubber solution by stirring at 70 to 90° C. for 8 to 12 hours. At this time, if the stirring temperature is less than 70 ℃ or stirring for less than 8 hours, the production of the solution may not be complete and a defect may occur in the adhesive. can In addition, when stirring for more than 12 hours, there is no further effect, so it is uneconomical.

A mixed solution may be prepared by adding 20 to 40 parts by weight of styrene-isoprene-styrene rubber and 80 to 120 parts by weight of a tackifier to the natural rubber solution prepared as described above.

Styrene-butadiene-styrene (SBS) rubber is a synthetic rubber with a low glass transition temperature (Tg), composed only of hydrocarbons, low surface energy, and excellent wetting properties. The styrene-butadiene-styrene rubber preferably contains 20 to 30% by weight of styrene, which causes insufficient cohesion when the styrene content is less than 20% by weight, and insufficient adhesion when it exceeds 30% by weight. because there is

Although the said tackifier is not specifically limited, For example, a substituted saturated hydrocarbon resin (synthetic petroleum resin), a rosin ester derivative, a terpene type resin, a phenol type resin, etc. are preferable. In addition, the substituted saturated hydrocarbon resin is not specifically limited.

The tackifier preferably has a softening point of 90 to 160° C., which generally refers to a temperature at which a material is deformed by heating to cause softening. Thus, the tackifier can begin to deform and soften at 90°C.

When the softening point of the tackifier is maintained at 90° C. or higher, it is advantageous in that thermal strain is reduced by maintaining the adhesion promoter in a glassy state under high temperature conditions, and high temperature reliability is easily secured. On the other hand, when the softening point of the tackifier is less than 90° C., the tackifier starts to soften under high-temperature conditions, which may cause a decrease in durability. In addition, when the softening point of the tackifier exceeds 160° C., the role of the tackifier at room temperature for promoting adhesion may be insignificant.

The mixed solution prepared as described above may also contain a curing agent. The curing agent may serve to increase the hardness of the pressure-sensitive adhesive to prevent the pressure-sensitive adhesive from flowing, and to increase heat resistance. The curing agent is preferably included in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of the natural rubber. This means that when the curing agent is included in an amount of less than 0.1 parts by weight, the curing reaction is not sufficient, so that the heat resistance decreases and the viscosity of the pressure-sensitive adhesive decreases. If it is lowered, residues may be generated, and when it is included in excess of 20 parts by weight, the hardness of the pressure-sensitive adhesive may be increased, which may cause a decrease in adhesive strength.

Such a curing agent can be used as a raw material suitable for isocyanate, epoxy, aziridine, aluminum chelate, etc. suitable for hydroxyl group, carbonyl group, maleic acid group, etc., which are functional groups of the rubber resin. It is best to use

After preparing the mixed solution as described above, 1 to 5 parts by weight of the polymer-based beads 221 may be added to the mixed solution and mixed to prepare an adhesive.

The polymer-based bead 221 refers to a sphere made of a polymer material and is soft and elastic, and when the double-sided adhesive tape is stretched horizontally and becomes thin, it protrudes to the outside of the adhesive layer and is exposed between the adherend and the adhesive layer. It serves to separate the adhesive layer and the human body without the adhesive residue while remarkably reducing the adhesive force by reducing the contact area of the body (see FIGS. 4 and 5).

The polymer-based beads 221 are preferably mixed in an amount of 1 to 5 parts by weight based on 100 parts by weight of the natural rubber. When it does not protrude properly to the outer surface of the pressure-sensitive adhesive, and when the polybur-based beads are included in excess of 5 parts by weight, the amount increases and may protrude to the surface of the pressure-sensitive adhesive, so that the adhesive force may be reduced.

The polymer-based beads 221 may be made of polymethyl methacrylate, nylon, polyurethane, polydecyl methacrylate, silica, or the like, and in particular, made of polydecyl methacrylate containing a hydroxy functional group. In the case of the beads, the hardening agent isocyanate and urethane reaction occur, so the bonding strength with the adhesive layer is excellent.

In addition, it is preferable that the polybur-based bead 221 is manufactured to have a thickness less than that of the adhesive layer 220 (see FIG. 4 ). In the present invention, since the pressure-sensitive adhesive may have a thickness of 1 to 200 μm, the polybur-based beads preferably have a size of 1 to 100 μm. In particular, in the case of the polymer-based bead, it is preferable to be buried in the adhesive layer and exposed only during stretching, so that the thickness of the adhesive is L and the diameter of the polymer-based bead is R, it is more preferable to have the following ratio.

[Equation 1]

R=(L/(100+p))X100+K

(This?? K is 1~50㎛, and p is the elongation (%) of the film)

The K denotes a removal rate of the pressure-sensitive adhesive by the polymer bead, and as the size of K increases, the amount of elongation is reduced when the adhesive tape is removed, but the adhesive strength of the adhesive material may be weakened. And it is preferable to adjust the stretching amount.

In addition, in the case of P, it represents the elongation of the film. When the elongation of the film is low, a bead having a thickness similar to the thickness of the adhesive layer should be used, and when the elongation of the film is high, it has a small diameter compared to the thickness of the pressure-sensitive adhesive It is preferable to select and use an appropriate bead according to each elongation using polymer beads.

Before adding the polymer-based beads, smooth surface treatment of the outer surface of the polymer-based beads; applying a lubricant to the outer surface of the smooth surface-treated polymer-based beads; and coating the mixed solution on the outer surface of the polymer-based beads to which the lubricant is applied to form a protective layer.

Since the polymer-based beads must protrude to the outer surface of the fixer when the pressure-sensitive adhesive is stretched, surface processing is preferably performed so as not to adhere to the adhesive (see FIG. 5 ). To this end, the surface of the polymer-based bead may be processed to be smooth, and then a lubricant may be applied. At this time, it is preferable to use a lubricant having low affinity with the adhesive, and it is more preferable to use a silicone-based lubricant, molybdenum lubricant, Teflon lubricant or mineral oil-based lubricant, and most preferably, it has high lubricity and low reactivity to the human body. You can use Teflon lubricants, which are known to be harmless.

The mixed solution may be applied to the surface of the polymer-based bead coated with the lubricant. Through this, when the polymer-based beads are mixed with the mixed solution, the generation of air bubbles can be minimized and it is possible to prevent agglomeration inside the mixed solution.

In addition, the mixed solution may further include one or more additives selected from the group consisting of a UV stabilizer, an antioxidant, a filler, and a plasticizer. These additives may be appropriately adjusted within a range that does not impair the physical properties of the pressure-sensitive adhesive composition.

The mixed solution prepared as described above may have a solid content of 20 to 30% by weight and a viscosity of 2500 to 3500 cps. When the solid content is less than 20% by weight, it is difficult to separate the pressure-sensitive adhesive, and residues may be generated. In addition, when the viscosity of the mixed solution is less than 2500 cps, the prepared adhesive may flow without being fixed, and if it has a viscosity exceeding 3500 cps, the adhesive strength may be reduced.

In the case of using the adhesive auxiliary layer as described above, the porous outer shell can be easily attached to the surface of the human body, and even when it is removed, the adhesive strength of the adhesive surface can be weakened by stretching it over a certain length in the longitudinal direction. It can be easily removed from

The adhesive surface 220 and the other side of the porous shell 100 may include a protective film 300 . The protective film is manufactured in the same size as the auxiliary adhesion layer 200 and may serve to protect the adhesion surface 220 of the adhesion auxiliary layer 200 and the other side 120 of the outer shell. In addition, the protective film may be divided into two or more pieces so that it can be easily removed from the adhesive surface and attached thereto. It is preferable that the pieces of each protective film are attached so that they overlap a certain width or more. That is, when the protective film has a plurality of pieces, since each protective film has an overlapping portion, a portion of the adhesive surface can be exposed by removing the protective film attached to the uppermost part, and the exposed adhesive surface is exposed to the human body. After attaching, the healing patch can be easily attached by removing the remaining protective film.

In the above, preferred embodiments of the present invention have been illustrated and described, but the present invention is not limited to the specific embodiments described above, and it is common in the technical field to which the present invention pertains without departing from the gist of the present invention as claimed in the claims. Various modifications are possible by those having the knowledge of, of course, these modifications should not be individually understood from the technical spirit or prospect of the present invention.

100: porous outer shell
110: semi-permeable membrane
120: porous layer
130: impermeable split film
140: porous powder
150: active ingredient
200: adhesion auxiliary layer
210: film
220: adhesive layer
221: polymer-based beads
300: protective film

Claims (2)

porous shell;
a porous powder contained in the porous shell to absorb human wastes;
an active ingredient contained in the porous shell;
an adhesive auxiliary layer attached to one side of the porous shell and having an adhesive surface on the other side; and
a protective film attached to the other side of the adhesive auxiliary layer and protecting the other side of the adhesive surface and the porous shell;
In the healing patch comprising a,
The porous outer shell is made of a semipermeable membrane having micropores having a size of 0.05 to 1 μm by stretching a fluororesin on one side, and a mesh, woven fabric, knitted fabric or nonwoven fabric having a porous structure on the other side,
The space between the porous shell,
It is separated into 2 to 100 loading spaces by an impermeable dividing film connecting one side and the other side of the porous shell,
The loading space optionally includes the porous powder or the active ingredient,
The porous powder is
Diatomaceous earth powder having an average particle size of 0.1 to 10 μm;
Activated carbon powder having an average particle size of 5 to 20 μm;
sodium bicarbonate; and
Desulfurized gypsum powder having an average particle size of 1 to 20 μm;
is a mixture of
The active ingredient is
Contains wood vinegar powder, herbal medicine powder and microcapsules,
The microcapsule is
preparing a nanoparticle complex solution by mixing nanoparticles in a solvent in which menthol is dissolved;
emulsifying the nanoparticle complex solution by mixing it with a temperature-dependent oil; and
It is prepared by a manufacturing method comprising the step of adding the emulsified solution to the coating solvent in which the coating material is dissolved, and treating the nanoparticle composite solution to be coated on the coating material and encapsulated into fine particles,
The nanoparticles include gold, silver, copper, titanium, selenium, magnesium, iron, vanadium, platinum, or an organic compound thereof
As the microcapsule has a film of 1 to 10 nm, the film is destroyed by pressing the porous outer shell,
The wood vinegar powder,
charging the wood into the heating furnace;
After replacing the inside of the heating furnace with an inert gas, heating the heating furnace to a temperature of 200 ~ 500 ℃;
collecting the liquid material by collecting and cooling the gas generated in the upper part of the heating furnace;
allowing the liquid material to stand for 1 to 20 days to phase-separate it into an oily component, an aqueous component, and a precipitate;
removing methanol by separating and re-distilling an aqueous component after the phase separation is completed;
Filtering the aqueous component from which the methanol has been removed with activated carbon to prepare a wood vinegar; and
Mixing 10-50 parts by weight of wood vinegar based on 100 parts by weight of starch, then drying and pulverizing to prepare wood vinegar powder;
It is prepared by a method comprising
The herbal medicine powder,
leaflet, gilgyeong, encyclopedia, yinyanggwak, ukjongyong, pagukcheon, baekbokshin, sanjoin, wonji, hyangbuja, seokchangpo, autograph, gardenia, jinpi, mokhyang, shiho, cheongung, angelic, gobon, windbreak, ginseng, earthenware, yukjongyong, cheoncho, shinihwa , Choyeop, mint, Ayeop, Baeksil, Biryeom, Wooseul, Betel nut, Gwakhyang, Sansa, Banseok, Health, White paper, and then washing one or more medicinal materials selected from Gilgyeong, and then pulverizing to a size of 0.1 to 5mm; and
charging the pulverized medicine into the expander and then heating to a pressure of 1 to 3 Mpa and a temperature of 100 to 300° C. to expand;
It is prepared by a method comprising
The adhesive auxiliary layer is
Preparing a thermoplastic polyurethane film that can be stretched horizontally; and
coating an adhesive on the upper and lower surfaces of the polyurethane film;
It is prepared by a method comprising;
The adhesive is
preparing a peptized rubber solution by mixing 0.2 to 0.5 parts by weight of a peptizing agent and 650 to 700 parts by weight of toluene with respect to 100 parts by weight of natural rubber and stirring at 70 to 90° C. for 8 to 12 hours;
preparing a mixed solution by adding 20 to 40 parts by weight of styrene-isoprene-styrene rubber and 80 to 120 parts by weight of a tackifier to 100 parts by weight of natural rubber to the peptized rubber solution;
preparing a pressure-sensitive adhesive by adding and mixing 1 to 5 parts by weight of polymer beads based on 100 parts by weight of natural rubber to the mixed solution;
Healing patch, characterized in that manufactured by a method comprising a.
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