KR102269721B1 - Micro-needle bullet injection apparaus for endoscope - Google Patents

Abstract

The disclosed microneedle bullet injection device for endoscopy according to the present invention is a hollow body that can be inserted into an endoscope channel and has a movable space therein, contains a chemical that can penetrate the skin, and is loaded at the tip of the body based on the penetration direction. It includes a microneedle bullet and a manipulation unit for penetrating the loaded microneedle bullet into the skin using an elastic force provided in the movable space of the main body. According to this configuration, it is possible to permeate a predetermined amount of the chemical solution through the mucosal skin into the tissue requiring treatment through a simple operation, thereby contributing to the improvement of treatment reliability.

Description

Microneedle bullet injection device for endoscopy {MICRO-NEEDLE BULLET INJECTION APPARAUS FOR ENDOSCOPE}

The present invention relates to a microneedle bullet injection device for an endoscope, and more particularly, is mounted on an endoscope channel to enable delivery of a drug through the mucosal skin to a tissue requiring treatment to improve penetration accuracy into the mucosal skin and a quantitative drug solution It relates to an endoscope microneedle bullet injection device capable of delivery.

During endoscopy of the stomach, colon, and bladder, various treatments such as polyp removal, mucosal and submucosal resection, dilatation, and stent insertion can be performed for the purpose of diagnosis as well as treatment. The following are the cases of injecting drugs such as botox into the stomach or bladder muscle.

First of all, in the case of bladder disease, despite the fact that the bladder is not filled with enough urine, the bladder muscle suddenly contracts and the overactive bladder (Urgency) has a strong urge to urinate (Micturition desire) Neurogenic detrusor overactivity disease, in which the nervous system that controls the overactive bladder) or the lower urinary tract is damaged, may occur. As a treatment for such overactive bladder or neurodetrusor overactive disease, it is common to take drugs along with lifestyle modification treatment. However, there is a problem that continuous treatment is difficult, along with side effects such as dry mouth and constipation that may be caused by drugs for treating bladder diseases.

In order to improve the drug treatment of bladder diseases, Botox is injected into the bladder muscle to block the secretion of neurotransmitters, thereby suppressing unnecessary contraction of the bladder muscle, thereby improving the symptoms of overactive bladder immediately.

In addition, when Botox is injected into the muscles in the stomach using a gastroscope, it is effective in treating obesity because it can decrease the movement of the stomach muscles to prolong the digestion time of food and maintain a feeling of satiety.

As such, in recent years, as botox treatment using an endoscopic procedure is applied in various ways, various studies are continuously being made to improve the accuracy of drug injection and the stability of the procedure.

Republic of Korea Patent Publication No. 10-2018-0081550

An object of the present invention is to provide an endoscopic microneedle bullet injection device that is mounted on an endoscopic channel to improve the penetration accuracy of drug delivery through mucosal skin to a tissue requiring treatment and can deliver a quantitative drug.

Another object of the present invention is to provide an endoscopic microneedle bullet injection device capable of penetrating the microneedle bullet to a desired position and depth, thereby improving treatment safety and reliability.

The microneedle bullet injection device for endoscope according to the present invention for achieving the above object is insertable into an endoscope channel, a hollow body part having a movable space therein, a chemical solution penetrating into the skin, and a direction of penetration. It includes a microneedle bullet that can be loaded at the tip of the main body as a reference, and a manipulation unit that is provided in the movable space of the main body and penetrates the loaded microneedle bullet into the skin by using an elastic force.

In addition, the body portion may include a catheter extending in the longitudinal direction in the penetration direction through which the microneedle bullet penetrates, and having the movable space therein parallel to the penetration direction.

In addition, the manipulation unit has a shape extending in the longitudinal direction in the penetrating direction in which the microneedle bullet penetrates and is inserted into the main body part to be movable in the penetrating direction, and the manipulation body based on the penetrating direction. A shaft extending toward the microneedle bullet from the tip of the shaft, selectively interfering with the microneedle bullet, an elastic member for elastically supporting the shaft, and an exposed hole formed through one side of the body portion to control the movement of the manipulation body It may include an interfering trigger and a trigger cover that is provided to be movable along the outer surface of the main body and selectively exposes the trigger according to the movement posture.

In addition, the front end of the manipulation body is connected to the shaft by a connecting member, and the rear end is connected to a cap fixed to close the open rear end of the main body, and the elastic member is interposed around the outer circumferential surface of the manipulation body, The elastic member is positioned between the connecting member and the cap, and may include a coil spring compressible according to the movement of the connecting member.

In addition, the trigger is provided rotatably around the hinge, and when the trigger cover is moved in the opposite direction to the penetration direction, the trigger is exposed and an external force is applied, the trigger is rotated around the hinge Interference with the shaft can be released.

In addition, the trigger cover may be provided with a stepped interference bump on at least a portion of a surface facing the trigger, and the range of movement in the penetration direction may be limited by the interference between the interference bump and the trigger.

In addition, a hollow penetration guider is connected to the front end of the manipulation body and extends in the penetration direction, and the shaft may be movable inside the penetration guider.

In addition, the penetration guider can be provided flexibly by being made of multiple twists.

In addition, a hollow chemical guider in which the microneedle bullet is loaded is coaxially connected to the penetration guider at the tip of the penetration guider based on the penetration direction, and the microneedle bullet is located at the tip of the chemical guider based on the penetration direction. A screen that can be torn by the penetrating force of the microneedle is provided to protect the microneedle bullet loaded in the chemical guider from the outside.

In addition, the chemical guider may be provided with the microneedle bullet from a loading unit having the microneedle bullet.

In addition, in a state in which the microneedle bullet is loaded in the main body, the trigger presses and compresses the elastic member in a direction opposite to the penetration, and the interference force between the trigger and the elastic member is reduced by the movement of the trigger. When released, the shaft may press the microneedle bullet by the elastic restoring force of the elastic member and discharge the microneedle bullet to the outside of the main body.

In addition, the microneedle bullet may have at least one of a tip shape, an arrowhead shape, a multi-stage shape, a screw shape, and a groove shape with a pointed tip based on the penetration direction into the skin.

In addition, the microneedle bullet may be provided by solidifying the drug solution containing at least a portion of Botox, and may be made of a material that can be absorbed into the body after penetrating the skin and releasing the drug solution.

In addition, in the microneedle bullet, a stopper for limiting the penetration depth into the skin is provided so that it can be folded or unfolded at the rear end based on the penetration direction, and the stopper of the microneedle bullet is in a folded state when loading the body part, It can be unfolded by elasticity in conjunction with being discharged from the main body.

Endoscopy microneedle bullet injection device according to a preferred embodiment according to another aspect of the present invention is an endoscopic microneedle bullet injection device for injecting microneedle bullets formed by solidifying a chemical solution that penetrates into the skin and dissolves into the skin. In the method, it can be inserted into the endoscope channel, and includes a hollow body portion to which the microneedle bullet is mounted on the tip portion, and a manipulation portion provided movably inside the body portion to discharge the microneedle bullet to the skin.

In addition, the body portion may include a catheter that extends in parallel to the penetration direction, and a movable space in which the manipulation unit is inserted and operated is provided parallel to the penetration direction.

In addition, the manipulation unit has a shape extending in parallel to the penetration direction and is inserted into the body portion to move in the penetration direction, and the microneedle bullet from the tip of the operating body based on the penetration direction. The elastic supporting shaft extending toward and selectively interfering with the microneedle bullet in association with the movement of the manipulation body, and a connecting member connecting the manipulation body and the shaft, is elastically supported to provide penetrating force to the manipulation body. A member, a trigger provided in an exposed hole formed through one side of the main body to selectively compress the elastic member by interfering with the movement of the manipulation body, and a trigger provided to be movable along the outer surface of the main body, according to the movement posture It may include a trigger cover selectively exposing the.

In addition, based on the penetration direction, the shaft is inserted into the front end of the main body to be connected to the movable hollow penetration guider and the penetration guider, and the hollow chemical guider in which the microneedle bullet is mounted is coaxial with each other. A cap is connected to the rear end of the main body to seal the inside, and an operation space in which the operating body is movable may be provided in the inside of the cap.

In addition, the penetration guider can be provided flexibly by being made of multiple twists.

In addition, the elastic member is interposed on the outer circumferential surface of the manipulation body, the elastic member is positioned between the connecting member and the cap, it may include a coil spring compressible according to the movement of the connecting member.

In addition, the trigger is provided rotatably around a hinge, and when the trigger cover is moved in the penetration direction or in the penetration direction to expose the trigger, the trigger is rotated by an external force to interfere with the elastic member This can be turned off.

In addition, in a state in which the microneedle bullet is loaded in the main body, the trigger compresses the elastic member by pressing the connecting member in the opposite direction to the penetration, and the trigger is exposed by the movement of the trigger cover to expose the external force When this is applied, the shaft presses the microneedle bullet in conjunction with the movement of the manipulation body in the penetration direction by the elastic restoring force of the elastic member, so that it can be discharged to the outside of the main body.

In addition, the chemical solution of the microneedle bullet contains at least a part of Botox, and is provided with a material that can be absorbed into the body after penetrating the skin and releasing the chemical solution, and the microneedle bullet has a pointed tip based on the penetration direction. It may have at least one of a tip shape, an arrowhead shape, a multi-stage shape, a screw shape, and a groove shape.

In addition, in the microneedle bullet, a stopper for limiting the depth of penetration into the skin is provided to be folded or unfolded at the rear end based on the penetration direction, and the stopper of the microneedle bullet is in a folded state when loaded in the body part. , It can be unfolded by elasticity in conjunction with being discharged from the main body.

In addition, a shield that can be torn by the penetrating force of the microneedle bullet is provided at the tip of the chemical guider based on the penetration direction to protect the microneedle bullet loaded in the chemical guider from the outside, and the chemical guider is the The microneedle bullet may be provided from a loading unit having a microneedle bullet.

According to the present invention having the above configuration, first, by loading the microneedle bullet, the drug solution can be accurately penetrated through the mucosal skin into the target tissue to be treated, thereby contributing to the improvement of the treatment accuracy according to the penetration accuracy. do.

Second, due to the simple operation of loading and penetrating the microneedle bullet using elastic force, it can contribute to the improvement of usability.

Third, by limiting the penetration depth of the microneedle bullet into the skin, the microneedle bullet containing the solidified chemical can be dissolved in the body for a sufficient period of time, making it possible to provide a fixed amount of the chemical.

Fourth, even if the microneedle bullet penetrates into the skin with a strong force, it does not penetrate the skin, so the safety is excellent.

Fifth, the drug solution can be accurately penetrated into the mucosal tissue of the skin, which has many wrinkles and elasticity, which is advantageous in securing treatment diversity.

1 is a cross-sectional view schematically showing an endoscope microneedle bullet injection device according to a preferred embodiment of the present invention.
FIG. 2 is a cross-sectional view schematically illustrating a state in which the microneedle bullet of the microneedle bullet injection device for an endoscope shown in FIG. 1 is mounted on the main body.
3 is a cross-sectional view schematically illustrating a state in which the microneedle bullet is discharged from the main body and penetrated by a trigger operation.
4 is a cross-sectional view schematically illustrating a state in which the operation unit is loaded by a trigger operation. And,
FIG. 5 is a diagram schematically illustrating a stopper operation of the microneedle bullet shown in FIG. 1 .

Hereinafter, a preferred embodiment of the present invention will be described with reference to the accompanying drawings. However, the spirit of the present invention is not limited to such embodiments, and the spirit of the present invention may be proposed differently by adding, changing, and deleting components constituting the embodiment, but this is also included in the scope of the present invention. will become

As shown in FIG. 1 , an endoscope microneedle bullet injection device 1 according to an embodiment of the present invention includes a body portion 10 , a microneedle bullet 20 , and an operation unit 30 .

For reference, the microneedle bullet injection device for endoscopy described in the present invention (1) is mounted on an endoscope that can enter and operate internal organs such as the stomach and bladder, and injects a chemical solution such as Botox into the tissue requiring treatment. It is exemplified by penetrating a fixed amount of the chemical solution through the skin. However, the present invention is not necessarily limited thereto, and it is natural that various types of liquids including Botox can be penetrated into the skin by being applied to various surgical devices including an endoscope.

The main body 10 can be inserted into an endoscope channel (not shown), and has a hollow cylindrical shape to support the microneedle bullet 20 and the manipulation unit 30 to be described later. The main body 10 extends in the longitudinal direction parallel to the penetration direction in which the microneedle bullet 20 penetrates into the mucosal skin of the tissue requiring treatment, and a movable space 10a into which the manipulation unit 30 can be inserted and operated. ) is illustrated as including a catheter having a (Catheter).

This body portion 10 extends parallel to the tip in the penetration direction based on the penetration direction in which the microneedle bullet 20 to be described later penetrates into the skin, and the penetration guider 11 having a hollow tube shape is coupled to protrude. do. In addition, at the tip of the penetration guider 11 of the main body 10, the chemical guider 12 in which the microneedle bullet 20 is loaded is coupled to have a hollow tube shape.

For reference, the penetration guider 11 is preferably made of multiple twists and has a flexible characteristic. Since the penetration guider 11 is provided flexibly in this way, it is possible to prevent damage to the skin due to the penetration guider 11 as well as access to a desired penetration site.

The microneedle bullet 20 can be loaded at the tip of the main body 10 and is provided by solidifying a chemical that can penetrate into the skin. These microneedle bullets 20 are provided in the form of a kind of bullet having a tip 21 shape with a sharp tip, and penetrate into the skin and dissolve by the manipulation unit 30 to be described later.

Here, the microneedle bullet 20 may be made of a biocompatible material that can be absorbed into the body after penetrating into the mucous membrane of the skin and releasing the drug solution, and the dissolution rate of the microneedle bullet 20 and the release of the drug solution The rate is adjustable through the formulation process. In addition, it is preferable that the microneedle bullet 20 solidified by containing a chemical solution in a biocompatible material has sufficient mechanical strength to penetrate a mucous membrane having many wrinkles and elasticity. To this end, the microneedle bullet 20 is preferably provided in various shapes such as arrowheads, multi-stages, screws, grooves, etc. to have a sharp tip like the tip 11 .

As shown in FIG. 2 , the microneedle bullet 20 is loaded on the body part 10 to be described later by the loading part 22 . The loading part 22 has a hollow shape in which a loading groove 23 extending in the longitudinal direction is provided therein, and the microneedle bullet 20 is inserted into the loading groove 23 . On the other hand, a pressing member 24 having one end entering the microneedle bullet 20 and the other end extending from one end in the longitudinal direction to the outside of the charging unit 22 is inserted into the loading groove 23, The pressing member 24 is slidable along the loading groove 23 .

At one side of the loading part 22, a connection groove 22a in which the chemical guide 12 provided in the main body 10 is inserted and connected to a predetermined depth is formed in a stepped manner. In a state where the chemical guider 12 is inserted into the connection groove 22a, the pressing member 24 presses the microneedle bullet 20 located in the loading groove 23 with the chemical guider 12, so that the microneedle The bullet 20 is loaded in the chemical guider 12 .

For reference, one end and the other end of the chemical guide 12 have an open shape. At one end facing the tip 21 of the microneedle bullet 20, a shield 13 such as Farafilm can protect the microneedle bullet 20 from external foreign substances by isolating the outside and the inside from each other. This can be provided. Here, as the shield 13 is easily torn by the tip 21 of the microneedle bullet 20 due to the material properties, the microneedle bullet 20 is connected to the main body 10 by the manipulation unit 30 to be described later. does not interfere with the emission from At this time, after the microneedle bullet 20 is loaded into the chemical guider 12 by the loading unit 22 , the shield 13 may be provided at the tip of the chemical guider 12 .

In addition, the chemical guider 12 is coaxially coupled to the penetration guider 11, so that the microneedle bullet 20 mounted on the chemical guide 12 is mounted in a state of coaxial alignment with the operation unit 30 to be described later, so that the penetration accuracy It can also contribute to improvement.

The manipulation unit 30 provides a penetrating force capable of penetrating the microneedle bullet 20 loaded in the body unit 10 into the mucosal skin of the tissue to be treated with a selectively compressible elastic force. The operation unit 30 includes an operation body 31 , a shaft 32 , an elastic member 33 , a trigger 34 , and a trigger cover 35 .

The operation body 31 is inserted into the body portion 10 . The manipulation body 31 has a cylindrical shape and is inserted into the movable space 10a inside the main body 10, so that it is slidable along the movable space 10a.

Here, the rear end of the body portion 10 facing the front end of the body portion 10 on which the penetration guider 11 is provided has an open shape, and a cap 14 is mounted on the rear end of the open body portion 10 . It is good to prevent the separation of the operating body (31). More specifically, a movable space 10a is provided parallel to the penetration direction between the front end and the rear end of the main body 10 , and the microneedle bullet 20 is loaded at the front end of the main body 10 , and a cap is provided at the rear end. (14) is installed to seal the inside. Therefore, the operating body 31 is slidably operated only within the movable space 10a between the front end and the rear end of the main body 10 , and is not discharged to the outside through the open rear end of the main body 10 .

Here, one end of the cap 14 supports the rear end extending in the longitudinal direction from the front end of the manipulation body 31 facing the microneedle bullet 20, and the movable space 10a of the main body 10 and A communicating operating space 15 is provided. In addition, the other end of the cap 14 is provided to extend in the longitudinal direction from one end to extend to the outside of the main body (10). At this time, it is preferable that the other end of the cap 14 is provided with an operating end 16 extending in the radial direction for the user's gripping convenience.

The shaft 32 extends from the tip of the manipulation body 31 toward the microneedle bullet 20 based on the penetration direction of the microneedle bullet 20 , and selectively interferes with the microneedle bullet 20 . One end of the shaft 32 is a fixed end inserted a predetermined depth into the front end of the manipulation body 31, and the other end extends from one end in the longitudinal direction parallel to the permeation direction, and the penetration guider 11 and the chemical solution guider 12 are inside. It is provided with a free end inserted into the. In addition, the shaft 32 is preferably formed of a flexible metal material such as wire or a plastic material.

Here, one end of the shaft 32 is connected to the operating body 31 by a connecting member 31a coupled to the distal end of the operating body 31 . The connecting member 31a is coupled to the front end of the operating body 31 while supporting the shaft 32 , thereby limiting the insertion depth of the shaft 32 into the operating body 31 . In addition, the connection member 31a connects between the operation body 31 and the shaft 32 so that the shaft 32 is slidably movable in association with the movement of the operation body 31 .

The elastic member 33 elastically supports the shaft 32 to provide an elastic pressing force for operating the shaft 32 . Here, the elastic member 33 is interposed in the operating body 31 , interposed between the connecting member 31a coupled to the front end of the operating body 31 and the cap 14 supporting the rear end of the operating body 31 . It is exemplified as including a coil spring that is

At this time, the cap 14 is fixed to the main body 10, and the connecting member 31a is movable in association with the operating body 31, so that the operating body (10a) in the movable space (10a) of the main body (10). 31) The elastic member 33 is compressed or tensioned in conjunction with the sliding operation.

More specifically, when the operating body 31 slides toward the rear end (opposite to penetration) of the main body 10 as shown in FIG. 3 , the connection member 31a coupled to the front end of the operating body 31 is also included in the main body portion. It moves toward the rear end of (10). Accordingly, the elastic member 33 interposed between the connecting member 31a and the cap 14 is compressed in association with the movement of the connecting member 31a. The elastic operation of the elastic member 33 will be described later in more detail along with the penetrating operation of the microneedle bullet injection device 1 for the endoscope.

For reference, the connecting member 31a and the cap 14 respectively connected to the front end and the rear end of the manipulation body 31 have a diameter that is larger than the outer diameter of the manipulation body 31 and are in close contact with the inner diameter of the movable space 10a. . Accordingly, the elastic member 33 can be interposed in a space spaced apart between the inner diameter of the main body 10 and the outer diameter of the operation body 31 between the connecting member 31a and the cap 14 .

The trigger 34 may be inserted into the exposure hole 17 formed through one side of the main body 10 to interfere with the manipulation body 31 . The trigger 34 is provided rotatably around the hinge 34a, as shown in FIGS. 3 and 4 . In addition, the trigger 34 is provided with first and second trigger ends 34b and 34c protruding from both ends extending in the longitudinal direction about the hinge 34a.

The first trigger end 34b of the trigger 34 protrudes toward the outside of the main body 10 , and the second trigger end 34c protrudes toward the inside of the main body 10 . Therefore, the first trigger end 34b is exposed to the outside through the exposure hole 17 of the main body 10, and the second trigger end 34c is a control body that slides inside the main body 10. 31) will interfere. Here, the second trigger end 34c interferes with the connecting member 31a coupled to the front end of the manipulation body 31 , and is exemplified as protruding obliquely from the trigger 34 .

The trigger cover 35 is movably provided on the main body 10 to expose the trigger 34 so that the trigger 34 can be rotated around the hinge 34a according to the movement posture. The trigger cover 35 has a hollow cylindrical shape surrounding the outer diameter of the main body 10 so as to cover the exposed hole 17 of the main body 10 .

At this time, the trigger cover 35 has a stepped interference protrusion 35a is formed to face the exposure hole 17 . Here, the interference protrusion 35a provided on the trigger cover 35 interferes with the first trigger end 34b through the exposure hole 17 , thereby limiting the advance range of the trigger cover 35 in the penetration direction.

On the other hand, as shown in FIG. 3 , when the trigger cover 35 slides in the opposite direction to penetration along the outer diameter of the main body 10 , the first trigger end 34b of the trigger 34 provided in the exposure hole 17 ) this is exposed An external force is applied to the exposed first trigger end 34b by the user and is pressed in the arrow direction, so that the trigger 34 is rotated around the hinge 34a. Therefore, the interference force between the trigger 34 and the connecting member 31a is released, and the compressive force of the elastic member 33 is released.

On the other hand, as shown in Figure 5, the microneedle bullet 20 is provided with a stopper (20a) for limiting the depth of penetration into the skin. The stopper 20a may be provided with elasticity so as to be folded or unfolded at the rear end extending from the tip 21 provided at the front end of the microneedle bullet 20 .

More specifically, as shown in FIG. 5(a), in a state in which the microneedle bullet 20 is loaded inside the chemical solution guider 12, the stopper 20a of the microneedle bullet 20 is a chemical solution guider ( 12) only in the guider hole 12a is in a state of being unfolded at a predetermined angle. The microneedle bullet 20 is linked to the operation of leaving the chemical guider 12 as shown in FIG. 5(b) so that the stopper 20a is folded so as to be in close contact with the side of the microneedle bullet 20, and the chemical guider ( 12) and at the same time as shown in FIG. 5(c), the stopper 20a is fully unfolded. Accordingly, the microneedle bullet 20 can penetrate into the skin only by the length (h) shown in FIG. 5(c) with respect to the skin.

The penetrating operation of the microneedle bullet injection device 1 for an endoscope according to the present invention having the above configuration will be described with reference to FIGS. 1 to 4 .

First, as shown in FIG. 2, when the chemical guider 12 coaxial with the penetration guider 11 of the main body 10 is inserted into the connection groove 22a of the loading part 22, the loading groove of the loading part 22 According to (23), the pressing member (24) presses the microneedle bullet (20). Accordingly, as shown in FIG. 1 , the microneedle bullet 20 is discharged from the loading unit 22 , and the microneedle bullet 20 is loaded in the connected chemical guider 12 . At this time, the stopper 20a of the microneedle bullet 20 loaded on the chemical guider 12 is in a state of being expanded only to the extent that it is inserted into the guider hole 12a of the chemical guider 12 (see Fig. 5 (a)). .

In a state in which the microneedle bullet 20 is loaded in the body part 10, insert the body part 10 into an endoscope channel (not shown) and insert the body part 10 to face the mucosal skin of the tissue requiring treatment. place it At this time, as shown in FIG. 1 , an elastic member 33 positioned between the connecting member 31a and the cap 14 is placed inside the main body 10 on which the microneedle bullet 20 is loaded by the trigger 34 . It is in a state of being compressed in the opposite direction to penetration. That is, as the elastic member 33 is compressed by the connecting member 31a interfered by the trigger 34, the microneedle bullet 20 is in a loaded state for penetration.

Thereafter, as shown in FIG. 3 , the trigger cover 35 is moved in the direction of the arrow shown, that is, in the opposite direction of penetration. Therefore, the trigger 34 is exposed through the exposure hole 17, and by pressing the first trigger end 34b of the exposed trigger 34 in the direction of the arrow, the trigger 34 is moved around the hinge 34a. rotates in the direction of the arrow.

At this time, since the second trigger end 34c of the trigger 34 is rotated upward, the interference force of the connection member 31a pressing the elastic member 33 due to the interference of the second trigger end 34c is also released. do. Therefore, the connecting member 31a is elastically pressed in the penetration direction in association with the elastic restoring force of the compressed elastic member 33 .

In conjunction with the movement of the connecting member (31a), the front end of the operating body 31 connected to the connecting member (31a) also moves, and the shaft 32 connected to the front end of the operating body 31 is the penetration guider (11). Guided in the direction of penetration from the inside. As a result, the shaft 32 is advanced in the penetration direction at a high speed within the penetration guider 11 to press the microneedle bullet 20 .

Here, as the shaft 32 presses the microneedle bullet 20 with a strong force by the elastic restoring force of the elastic member 33, the microneedle bullet 20 tears the shield 13 of the chemical guider 12, and the skin will be discharged towards For reference, the microneedle bullet 20 is discharged with sufficient force to penetrate the target skin including the mucous membrane with many wrinkles and elasticity, so that a predetermined amount of the chemical can be infiltrated into the tissue requiring treatment through the mucosal skin. do.

In addition, as the microneedle bullet 20 is spread out by the elastic force in the folded state while the microneedle bullet 20 leaves the chemical guide 12 as shown in FIGS. 5 (b) and (c), the mucous membrane of the tissue requiring treatment The depth of penetration into the skin is limited. Therefore, even if the microneedle bullet 20 leaves the body portion 10 with a strong force, it is inserted to a desired depth without penetrating the internal tissue to provide a chemical solution. The microneedle bullet 20 penetrating into the skin in this way is dissolved with a sufficient time to penetrate a predetermined amount of the chemical into the tissue requiring treatment.

After the microneedle bullet 20 penetrates into the skin, as shown in FIG. 4 , the trigger cover 35 returns to its original position, so that the elastic force of the elastic member 33 of the operation unit 30 is compressed again and the microneedle bullet (20) waits for the next operation to penetrate.

As described above, although described with reference to preferred embodiments of the present invention, those skilled in the art can variously modify and change the present invention without departing from the spirit and scope of the present invention as set forth in the following claims. You will understand that it can be done.

1: Endoscope microneedle bullet injection device 10: Body part
11: Penetration guider 12: Chemical liquid guider
13: shield 14: cap
20: microneedle bullet 20: stopper
21: Tip 22: Loader
23: loading groove 24: pressing member
30: operation unit 31: operation body
32: shaft 33: elastic member
34: trigger 35: trigger cover

Claims (25)

It can be inserted into the endoscope channel, the hollow body portion is provided with a movable space therein;
a microneedle bullet containing a chemical that can penetrate into the skin, and which can be loaded at the tip of the body part based on the penetration direction; and
a manipulation unit provided in the movable space of the main body and penetrating the loaded microneedle bullet into the skin using an elastic force;
includes,
The microneedle bullet is provided so that a stopper for limiting the depth of penetration into the skin can be folded or unfolded at the rear end based on the penetration direction,
The stopper of the microneedle bullet is in a folded state when the body part is loaded, and the microneedle bullet injection device for an endoscope is expanded by elasticity in conjunction with being discharged from the body part. According to claim 1,
The body part,
Endoscopy microneedle bullet injection device including a catheter extending in the longitudinal direction in the penetration direction through which the microneedle bullet is penetrated, and the movable space therein is provided parallel to the penetration direction. According to claim 1,
The operation unit,
an operation body having a shape extending in the longitudinal direction in the penetration direction into which the microneedle bullet is penetrated and being inserted into the body portion and movable in the penetration direction;
a shaft extending toward the microneedle bullet from the tip of the manipulation body based on the penetration direction, and selectively interfering with the microneedle bullet;
an elastic member elastically supporting the shaft;
a trigger provided in an exposure hole formed through one side of the main body to interfere with the movement of the manipulation body; and
a trigger cover provided to be movable along the outer surface of the main body, exposing the trigger according to the movement posture;
Endoscope microneedle bullet injection device comprising a. 4. The method of claim 3,
The front end of the manipulation body is connected to the shaft by a connecting member, and the rear end is connected to a cap fixed to close the open rear end of the main body,
An endoscope microneedle bullet injection device comprising an elastic member interposed between the outer circumferential surface of the manipulation body, and wherein the elastic member is positioned between the connecting member and the cap, and is compressible according to the movement of the connecting member. 4. The method of claim 3,
The trigger is provided rotatably around the hinge,
When the trigger cover is moved in the opposite direction to the penetration direction, the trigger is exposed and an external force is applied, the trigger is rotated about the hinge to release the interference with the shaft. 4. The method of claim 3,
The trigger cover is provided with a stepped interference bump on at least a portion of a surface facing the trigger,
An endoscope microneedle bullet injection device in which the range of movement in the penetration direction is limited by the interference between the interference jaw and the trigger. 4. The method of claim 3,
A hollow penetration guider is connected to the front end of the manipulation body and extends in the penetration direction,
The shaft is an endoscope microneedle bullet injection device movable inside the penetration guider. 8. The method of claim 7,
The penetration guider is an endoscope microneedle bullet injection device that is made of multiple twists and is flexibly provided. 8. The method of claim 7,
At the tip of the penetration guider based on the penetration direction, a hollow chemical guider in which the microneedle bullet is loaded is coaxially connected to the penetration guider,
An endoscopic microneedle bullet injection device for protecting the microneedle bullet loaded in the chemical guider from the outside is provided at the tip of the chemical guider based on the penetration direction, with a screen that can be torn by the penetrating force of the microneedle bullet. . 10. The method of claim 9,
The medicament guider is an endoscope microneedle bullet injection device that can receive the microneedle bullet from a loading unit having the microneedle bullet. 4. The method of claim 3,
In a state in which the microneedle bullet is loaded in the main body, the trigger presses and compresses the elastic member in the opposite direction to the penetration,
When the interference force between the trigger and the elastic member is released by the movement of the trigger, the shaft presses the microneedle bullet by the elastic restoring force of the elastic member and discharges the microneedle bullet to the outside of the main body. injection device. According to claim 1,
The microneedle bullet is an endoscope microneedle bullet injection device having at least one shape of a tip shape, an arrowhead shape, a multi-stage shape, a screw shape, and a groove shape, based on the penetration direction of the microneedle penetrating into the skin. . According to claim 1,
The microneedle bullet is an endoscopic microneedle bullet injection device in which the drug solution containing at least a part of botox is solidified, and is made of a material that can be absorbed into the body after penetrating the skin and releasing the drug solution. delete In the endoscopic microneedle bullet injection device for injecting the microneedle bullet formed by solidifying the chemical solution that penetrates into the skin and dissolves into the skin,
a hollow body part insertable into the endoscope channel and having the microneedle bullet mounted at the distal end; and
a manipulation unit provided movably inside the body unit to discharge the microneedle bullet to the skin;
includes,
The microneedle bullet is provided so that a stopper for limiting the penetration depth into the skin can be folded or unfolded at the rear end based on the penetration direction,
The stopper of the microneedle bullet is in a folded state when the body part is loaded, and the microneedle bullet injection device for an endoscope is expanded by elasticity in conjunction with being discharged from the body part. 16. The method of claim 15,
The body part,
Endoscopy microneedle bullet injection device including a catheter extending parallel to the infiltration direction, the movable space in which the manipulation unit is inserted and operated is provided parallel to the infiltration direction. 16. The method of claim 15,
The operation unit,
an operation body having a shape extending in parallel to the penetration direction and being inserted into the body portion and movable in the penetration direction;
a shaft extending from the tip of the manipulation body toward the microneedle bullet based on the penetration direction and selectively interfering with the microneedle bullet in association with the movement of the manipulation body;
an elastic member for elastically supporting a connecting member connecting the manipulation body and the shaft to provide penetrating force to the manipulation body;
a trigger provided in an exposure hole formed through one side of the main body to selectively compress the elastic member by interfering with the movement of the manipulation body; and
a trigger cover that is provided to be movable along the outer surface of the main body and selectively exposes the trigger according to the movement posture;
Endoscope microneedle bullet injection device comprising a. 18. The method of claim 17,
Based on the penetration direction, at the front end of the body part, the shaft is inserted therein and is provided to be connected to the movable hollow penetration guider and the penetration guider. The hollow chemical guider in which the microneedle bullet is mounted is coaxially connected to each other, and ,
An endoscope microneedle bullet injection device in which a cap for sealing the interior is mounted on the rear end of the main body, and an operation space in which the operation body is movable is provided inside the cap. 19. The method of claim 18,
The penetration guider is an endoscope microneedle bullet injection device that is made of multiple twists and is flexibly provided. 19. The method of claim 18,
The elastic member is interposed on the outer circumferential surface of the manipulation body,
The elastic member is positioned between the connecting member and the cap, the endoscope microneedle bullet injection device comprising a coil spring compressible according to the movement of the connecting member. 18. The method of claim 17,
The trigger is provided rotatably around a hinge,
When the trigger cover is moved in the penetration direction or the penetration direction to expose the trigger, the trigger is rotated by an external force to release the interference force with the elastic member. 18. The method of claim 17,
In a state in which the microneedle bullet is loaded in the main body, the trigger compresses the elastic member by pressing the connecting member in the opposite direction to the penetration,
When the trigger is exposed by the movement of the trigger cover and an external force is applied, the shaft presses the microneedle bullet in conjunction with the movement of the manipulation body in the penetration direction by the elastic restoring force of the elastic member to press the microneedle bullet, the main body Endoscope microneedle bullet injection device that discharges to the outside of the body. 16. The method of claim 15,
The chemical solution of the microneedle bullet includes at least a part of Botox, and is provided with a material that can be absorbed into the body after penetrating the skin and releasing the chemical solution,
The microneedle bullet is an endoscope microneedle bullet injection device having at least one of a tip shape, an arrowhead shape, a multi-step shape, a screw shape, and a groove shape with a pointed tip based on the penetration direction. delete 20. The method of claim 19,
A screen that can be torn by the penetrating force of the microneedle bullet is provided at the tip of the chemical guider based on the penetration direction to protect the microneedle bullet loaded in the chemical guider from the outside,
The medicament guider is an endoscope microneedle bullet injection device that can receive the microneedle bullet from a loading unit having the microneedle bullet.

Images