KR102252760B1 - Device for picking-up skin tissue - Google Patents

Abstract

The present invention is a skin tissue collection capable of increasing the collection rate of skin tissue and enabling effective skin tissue collection in collecting skin tissue of a fine size from normal skin tissue using a hollow microneedle for transplantation of fine skin. To provide a device. For this purpose, the apparatus for collecting skin tissue according to an embodiment of the present invention includes: a needle portion having a hollow inside and inserted into the skin; A driving unit driving the needle unit to rotate; And it is connected to the pressure control unit and communicates with the hollow interior of the needle unit, and the internal air pressure is controlled by the pressure control unit, so that air is sucked from the hollow interior of the needle unit and through the hollow interior of the needle unit. It includes an operation unit that selectively performs any one of air discharge to discharge air.

Description

Skin tissue collecting device {DEVICE FOR PICKING-UP SKIN TISSUE}

The present invention relates to an apparatus for collecting skin tissue, and more particularly, to an apparatus for collecting tissue by inserting a hollow microneedle into the skin as an apparatus for collecting biological tissue from the skin for skin transplantation.

Typically, in the case of skin diseases such as vitiligo, drug treatment or non-surgical treatment using light or laser is used, and these treatments have problems such as side effects, a long treatment period, and a need to perform multiple procedures.

Recently, as a treatment that can effectively treat skin diseases such as vitiligo in a short period of time, skin graft surgery in which normal tissue skin is collected and transplanted to the lesion site is attracting attention. Such skin transplantation can solve the problems of the non-surgical treatment described above. It is known to have an advantage.

However, in the case of conventional skin transplantation, a device used for hair collection is used when skin tissue is collected for skin transplantation.In the case of a device used for hair collection, the size of the tip inserted into the skin is large. Because the perforated area of the skin is wide, there is a problem that the recovery speed is slow and scars occur.Since the relatively large skin tissue is removed, such a large skin tissue is engrafted at the rate of engraftment, that is, as a normal tissue when the skin tissue is transplanted to the lesion site. There was a problem that the probability of landing was not high.

In order to solve this problem, a microepidermal transplantation technique has been developed in which a hollow microneedle is inserted into the skin, and by using it, a skin tissue having a fine size enough to be inserted into the hollow interior of the microneedle is removed and implanted.

For such microepidermal transplantation, skin tissue of very fine size is collected from normal skin, stored, and used when the stored skin tissue is transplanted to a lesion site.

However, since it is to collect skin tissue of a very fine size from the skin, it is very difficult to collect and store it effectively, and there is a problem in that the collection rate of the skin tissue is low.

The following documents have been published as prior art documents related to the prior art as described above.

Patent application No. 10-2013-0088470

Patent application No. 10-2015-0009919

Patent application No. 10-2017-7012153

The present invention is a skin tissue collection capable of increasing the collection rate of skin tissue and enabling effective skin tissue collection in collecting skin tissue of a fine size from normal skin tissue using a hollow microneedle for transplantation of fine skin. To provide a device.

A skin tissue collecting device according to an embodiment of the present invention includes: a needle portion having a hollow inside and inserted into the skin; A driving unit driving the needle unit to rotate; And it is connected to the pressure control unit and communicates with the hollow interior of the needle unit, and the internal air pressure is controlled by the pressure control unit, so that air is sucked in from the hollow interior of the needle unit and through the hollow interior of the needle unit. Including an operation unit that selectively performs any one of air discharge for discharging air, inserting a needle portion rotating by the driving unit into the skin, and collecting skin tissue inside the hollow of the needle unit by inhaling air from the operation unit, and It is characterized in that the skin tissue is separated from the hollow interior of the needle part by air discharge of the operation part.

In addition, preferably, the driving unit is configured to drive the needle unit in a lengthwise direction while driving the needle unit to rotate, but is configured to drive the needle unit stepwise so that the depth can be adjusted.

In addition, preferably, the needle portion includes a head portion provided at an upper portion and forming a passage portion therein, and a collecting portion provided under the head portion to form a hollow portion therein and inserted into the skin, and the head portion It is characterized in that to form a step portion that is inserted into the additional skin to form a step so that the skin tissue introduced into the hollow portion is caught.

In addition, preferably, the operation part is in communication with the passage part of the needle part, and the air suction and air discharge are performed by controlling the pressure of the pressure control part through the passage part.

In addition, preferably, the needle portion includes a collection needle that forms a hollow portion inside the skin and is inserted into the skin, and a needle cap having an upper end of the collection needle coupled or bonded to form a penetrating portion therein, and the collection needle is the needle It is characterized in that the collection needle is inserted into the skin as it is coupled or bonded to the cap so that the skin tissue introduced into the hollow part is caught on the lower end of the needle cap.

The skin tissue collecting device according to the present invention is a structure of a needle part in collecting fine-sized skin tissue from normal skin tissue by operation by an operation part while driving a needle part using a hollow microneedle as a driving part for implantation of fine skin It has the effect of increasing the rate of skin tissue collection and enabling effective skin tissue collection.

Figure 1 (a) is a view showing a schematic configuration of a skin tissue collecting device according to an embodiment of the present invention, (b) is a view showing the operation of the skin tissue collecting device according to another embodiment.
Figure 2 (a) is a view showing a cross-section II of the needle portion in Figure 1 (a), Figure 2 (b) is another for the needle portion of the skin tissue collecting apparatus according to an embodiment of the present invention It is a diagram showing the configuration of the embodiment.
3 and 4 are views showing a series of processes of collecting skin tissue by the skin tissue collecting apparatus according to an embodiment of the present invention, centering on a needle part.

Detailed contents of the apparatus for collecting skin tissue according to the present invention will be described with reference to the drawings.

First, a schematic configuration of a skin tissue collecting apparatus according to an embodiment of the present invention will be described with reference to FIG. 1.

The apparatus for collecting skin tissue according to an embodiment of the present invention may be implemented in the form of a handpiece so that the operator can carry it with his or her hand and perform the treatment on the operator. The main body 100 may be configured with a needle part 200, a driving part 300, and an operation part 400.

The needle part 200 is a component that has a hollow inside and is inserted into the skin to collect skin tissue.

The driving part 300 is a component that provides a driving force to rotate the needle part 200 with respect to the center of the needle part 200 as shown in FIG. 1(a), and in one direction It may be rotated only, or it may be configured to rotate in both left and right directions.

The driving unit 300 may be configured as a rotation driving motor, and may be directly or indirectly connected to the needle unit 200 through the operation unit 400 in the configuration as shown in FIG. 1A.

The axis of the driving unit 300, which is a rotation driving motor, may be directly connected to the needle unit 200 so that the needle unit 200 rotates together while the axis rotates, or the axis of the driving unit 300 and the needle unit ( It may be configured such that the rotational driving force of the driving unit 300 is indirectly transmitted to the needle unit 200 by connecting 200 through a power transmission means such as a gear.

Alternatively, as shown in (a) of FIG. 1, the driving unit 300, which is a rotation driving motor, is connected and fixed to the operation unit 400, and the operation unit 400 is connected and fixed to the needle unit 200, so that the The drive unit 300 may be configured to rotate the operation unit 400 so that the needle unit 200 connected and fixed to the operation unit 400 rotates together. ), the external pressure control unit 500 and the hose or tube (TB) are connected, but the driving unit 300 does not rotate the operation unit 400 in only one direction, but to the left and the right, respectively. When configured to rotate at a predetermined angle, the tube TB does not interfere with the rotation).

On the other hand, the operation unit 400 is connected to the external pressure control unit 500 and communicates with the hollow interior of the needle unit 200 to adjust the internal air pressure by the pressure control unit 500, so that the needle unit It is a component that selectively performs any one of air intake in which air is sucked in from the hollow interior of 200 and air discharge in which air is discharged through the hollow interior of the needle part 200.

The operation unit 400 may be implemented in the form of a chamber whose inside is sealed, and at this time, the hollow inside of the needle unit 200 may be configured to communicate with the inside of the chamber of the operation unit 400.

The pressure control unit 500 may be a component provided in a body (not shown) connected to the handpiece.

The pressure control unit 500 may be implemented as a device such as an air pump connected to the operation unit 400 by a tube TB, and by injecting air to the operation unit 400 through the tube TB The air pressure inside the operation part 400 may be increased, or, conversely, by sucking air from the operation part 400 through the tube TB, the air pressure may be lowered so that a negative pressure is formed inside the operation part 400.

In addition, the pressure control unit 500 may be configured to include and control a separate valve to facilitate injecting, inhaling, or blocking air into each tube TB.

On the other hand, the driving unit 300 may be basically implemented as a rotation driving motor that rotates the needle unit 200, but can be driven to rotate the needle unit 200, and the needle unit 200 in the longitudinal direction ( It may be configured to move in the direction of the arrow shown in (b) of FIG. 1, that is, in the vertical direction), but to be driven in stages to enable depth adjustment.

That is, the driving unit 300 may be configured to include a rotation driving motor that rotates the needle unit 200 in the left-right direction and a linear motor that moves the needle unit 200 in the vertical direction.

Alternatively, the motor may be configured to include only one rotation driving motor, and the linear movement of the needle part 200 includes a power transmission means for converting the rotational driving force of the rotation driving motor into linear driving.

As shown in (b) of FIG. 1, when the driving unit 300 is configured to move the needle unit 200 in a linear direction, the needle unit 200 is attached to the handpiece body ( 100) By placing it inside, it is possible to protect the needle part 200, and when collecting the skin tissue, the depth of the needle part 200 is finely adjusted while the needle part 200 is inserted into the skin so that the skin tissue can be collected. Therefore, it has the effect of enabling precise skin tissue collection.

On the other hand, with reference to Figure 2 will be described in more detail with respect to the specific configuration of the needle portion provided in the skin tissue collecting apparatus according to an embodiment of the present invention.

FIG. 2(a) shows an I-I cross section of the needle part 200 in FIG. 1(a). And Figure 2 (b) shows the configuration with respect to another embodiment of the needle portion.

As shown in (a) of FIG. 2, the needle part 200 may include a head part 220 on the upper side and a collecting part 210 on the lower side.

The head part 220 forms a passage part 222 therein, the collecting part 210 forms a hollow part 212 therein, and the passage part 222 and the hollow part 212 are It can be configured to communicate with each other.

The collecting part 210 forms a tip part 211 at the bottom so that it can be easily inserted into the skin, and the head part 220 and the collecting part 210 are At the boundary, the head portion 220 is characterized in that the step portion 223 is formed by forming a step inward.

That is, the collection unit 210 may be inserted into the skin to perform a function of limiting the skin tissue that is introduced into the hollow portion 212 to be caught by the stepped portion 223 and can no longer be introduced.

The stepped portion 223, as shown in Figure 2 (a), so that the diameter of the passage portion 222 of the head portion 220 is smaller than the diameter of the hollow portion 212 of the collecting portion 210 By doing so, it may be a part where a step is formed and appears.

The operation part 400 described in FIG. 1 is in communication with the passage part 222 of the head part 220 of the needle part 200 as described above (that is, the operation part 400, the passage part 222). And the hollow part 212 is preferably communicated with each other), through the passage part 222, air suction and air discharge, which will be described later, may be performed by controlling the pressure of the pressure control part 500 (see FIG. 1). .

On the other hand, the needle part 200 as shown in (a) of FIG. 2 is an example implemented in the form of an integrated needle, and in (b) of FIG. 2, a needle part of another form divided into two elements ( 250).

As shown in (b) of FIG. 2, the needle part 250 of another form may be configured to include a collecting needle 260 and a needle cap 270, and the collecting needle 260 is By combining or bonding to the needle cap 270, the whole may constitute one needle part.

The collecting needle 260 may be a universal hollow needle, and the tip portion 261 is formed at the end so as to be inserted into the skin by forming a hollow portion 262 therein.

The needle cap 270 is a portion to which the upper end of the collecting needle 260 is coupled or bonded, and forms a through portion 272 therein.

The collecting needle 260 may be coupled to the needle cap 270. In FIG. 2 (b), a coupling portion 271 is formed on the needle cap 270 so that the upper end of the collecting needle 260 is An example of a configuration that can be coupled to the coupling portion 271 of the needle cap 270 is shown.

The needle cap 270 is preferably formed in a diameter smaller than the diameter of the hollow portion 262 of the collecting needle 260, and the coupling portion 271 of the needle cap 270 By coupling the collecting needle 260 to, the lower end 273 of the needle cap 270 may be configured to form a step with respect to the collecting needle 260, as shown in (b) of FIG. 2.

That is, as shown in Figure 2 (b), as the collecting needle 260 is coupled (or bonded) to the needle cap 270, the lower end 273 of the needle cap 270 is shown in Figure 2 (a) The same role as the stepped portion described above, the skin tissue introduced into the hollow portion 262 of the collecting needle 260 may be configured to be caught on the lower end portion 273 of the needle cap 270.

3 for the operation and effect of the skin tissue collecting device according to an embodiment of the present invention to collect skin tissue by using the configuration of the needle part having the above-described configuration, the driving part driving the same, and the operation part. And it will be described with reference to FIG. 4.

3 and 4 are views showing a series of processes of collecting skin tissue by a skin tissue collecting device according to an embodiment of the present invention, centering on a needle part, in FIG. 3 (a) -> FIG. 3 ( b) -> Fig. 3 (c) -> Fig. 4 (a) -> Fig. 4 (b) shows an example of a process of collecting skin tissue in the order.

3 and 4 show the operation of the skin tissue collecting apparatus of the present invention centered on the needle part, and configurations of the driving part and the operation part other than the needle part are omitted.

As shown in (a) of FIG. 3, before inserting the collecting part 210 of the needle part 200 into the skin S, the skin (S) is easily inserted and the skin tissue is easily separated. The driving part is operated so that the needle part 200 is rotated in the direction of the arrow (the needle part may be rotated only in one direction or alternately in both directions).

As shown in (b) of FIG. 3, the collecting part 210 of the needle part 200 is inserted into the skin S, at this time, since the stepped part 223 is formed at the lower end of the head part 220 Insertion of the needle part 200 into the skin S may be limited to the insertion of the collecting part 210 by being caught in the stepped part 223.

Of course, as described above, when the depth of skin insertion of the needle part 200 is adjusted by the driving part, it may be inserted only up to a part of the collecting part 210.

And, as shown in (b) of FIG. 3, since the needle part 200 is rotated by the driving part while being inserted into the skin S, the skin tissue drawn into the inside (hollow part) of the collecting part 210 Silver can be easily separated from the surrounding skin.

As described above, when the skin (S) of the needle part 200 is inserted and the skin tissue to be collected is drawn into the collecting part 210, the rotational driving of the needle part 200 of the driving part is stopped, and the ( As shown in c), a negative pressure is formed inside the operation part by the pressure control of the pressure control part, and air is sucked through the passage part 222 of the head part 220 of the needle part 200.

When the air is inhaled as described above, the skin tissue drawn into the collection unit 210 by the pressure of the inhalation can be easily separated from the skin (S).

That is, as shown in (c) of FIG. 3, when the needle portion 200 is separated from the skin (S) while the air is inhaled, as shown in (a) of FIG. The skin tissue drawn into the hollow part 212 inside the collecting part 210 of the needle part 200 is separated from the skin S to be collected. At this time, the skin tissue collected and separated from the skin (S) is referred to as PS.

At this time, the negative pressure is formed by the air pressure control by the pressure control part inside the operation part, so that air intake is made as described above.The needle part is a fine needle with a diameter of about 0.4mm to 1.2mm, and the skin tissue collected by it is Because of its size, there is a risk of being sucked inward during the process of collecting skin tissue by air inhalation even at a small pressure.

However, since the needle portion of the skin tissue collecting apparatus according to an embodiment of the present invention, as described above, the step portion 223 forming a step with the collecting portion 210 at the bottom of the head portion 220 is formed, The skin tissue inserted into the hollow part 212 inside the collecting part 210 is caught by the stepped part 223 and is not sucked anymore despite the inhalation of air and is inserted into the hollow part 212 of the collecting part 210 It can be kept as it is.

That is, the configuration of the stepped portion as described above provides an important function to dramatically increase the collection rate even in the collection of fine skin tissue (as shown in Fig. 2(a) in Figs. 3 and 4). The operation of the needle portion of the shape is shown, but this can be applied equally to the needle portion of the shape as shown in (b) of FIG. 2).

In addition, as described above, when the driving unit includes a function that enables linear driving of the needle unit 200 in a longitudinal direction (that is, in the vertical direction in the drawing), the needle unit 200 is provided by the driving unit. The skin insertion depth of is adjusted so that the skin tissue as much as the depth at which the collecting unit 210 is inserted into the skin can be collected. For example, only a portion of the epidermis may be collected, or all skin tissues up to a part or all of the dermis including the epidermis may be collected.

At this time, depending on the skin tissue to be collected (for example, depending on whether the part to be collected is the epidermis or the dermis, etc.), the driving unit controls the depth of skin insertion of the needle unit 200 and at the same time, the intensity of air inhalation by the operating unit can be controlled. I can. For example, when collecting a thin area such as the epidermis, the pressure control unit can be controlled to lower the intensity of air intake, and when collecting a deeper skin tissue including the dermal layer, the intensity of air inhalation is slightly higher. The pressure control part can be controlled so that it is possible.

On the other hand, as shown in Figure 4 (a), after effectively collecting the skin tissue (PS) using the configuration of the step portion 223 of the air intake and the needle portion 200, the collected skin tissue (PS) Can be stored in separate storage means. In this case, the collected skin tissue (PS) can be easily separated from the collection unit 210 by the air pressure opposite to the pressure according to the air inhalation.

That is, as shown in (b) of FIG. 4, air is discharged from the operation part through the passage part 222 of the head part 220 of the needle part 200 by adjusting the pressure of the operation part by the pressure control part, That is, the skin tissue (PS) collected by the operation of blowing air toward the hollow part 212 of the collecting part 210 through the passage part 222 of the head part 220 is easily separated from the collecting part 210 Can come out.

Therefore, the skin tissue collecting apparatus according to an embodiment of the present invention as described above drives the needle unit using a hollow microneedle as a driving unit for implantation of fine skin, and operates by the operation unit to obtain a fine size from normal skin tissue. In collecting skin tissue, the needle part is composed of a head part and a collecting part, or a needle cap and a collecting needle are combined, so that the skin tissue collected by the suction force of air intake is collected by being caught in the stepped part of the head part or the lower part of the needle cap. Since it can be stably maintained without leaving the part or the collection needle, it has the advantage of increasing the collection rate of skin tissue and enabling effective collection of skin tissue.

100: handpiece body, 200: needle part
210: collection portion, 220: head portion
260: collecting needle, 270: needle cap
300: driving part, 400: operating part
500: pressure control unit

Claims (5)

The inside is hollow and the needle part is inserted into the skin;
A driving unit driving the needle unit to rotate; And
It is connected to the pressure control part and communicates with the hollow interior of the needle part, and the internal air pressure is controlled by the pressure control part, so that air is sucked in from the hollow interior of the needle part and air through the hollow interior of the needle part. Including an operation unit that selectively performs any one of the air discharge to discharge,
By inserting the needle part rotating by the driving part into the skin, the skin tissue inside the hollow of the needle part is collected by air inhalation of the operation part, and the skin tissue collected by the air discharge of the operation part is removed into the hollow part of the needle part. Separate from
The needle part,
It includes a head provided at the upper portion and forming a passage portion therein, and a collecting portion provided at the lower portion of the head portion to form a hollow portion therein and inserted into the skin,
The head portion is a skin tissue collecting device, characterized in that the step portion is inserted into the skin to form a step to form a step so that the skin tissue introduced into the hollow portion is caught. The method of claim 1, wherein the driving unit,
Skin tissue collecting device, characterized in that configured to be driven to rotate the needle portion while being able to move the needle portion in the longitudinal direction, but driven step by step so that the depth can be adjusted. delete The method of claim 1,
The operation part is in communication with the passage part of the needle part, and the air intake and air discharge are performed by controlling the pressure of the pressure control part through the passage part. The inside is hollow and the needle part is inserted into the skin;
A driving unit driving the needle unit to rotate; And
It is connected to the pressure control part and communicates with the hollow interior of the needle part, and the internal air pressure is controlled by the pressure control part, so that air is sucked in from the hollow interior of the needle part and air through the hollow interior of the needle part. Including an operation unit that selectively performs any one of the air discharge to discharge,
By inserting the needle part rotating by the driving part into the skin, the skin tissue inside the hollow of the needle part is collected by air inhalation of the operation part, and the skin tissue collected by the air discharge of the operation part is removed into the hollow part of the needle part. Separate from
The needle part,
It includes a collection needle that forms a hollow part inside and is inserted into the skin, and a needle cap that is coupled or bonded to the upper end of the collection needle to form a penetrating part therein,
Skin tissue collecting device, characterized in that configured such that as the collecting needle is coupled or bonded to the needle cap, the collecting needle is inserted into the skin so that the skin tissue introduced into the hollow part is caught on the lower end of the needle cap.

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