KR102215571B1 - Shooting device for microstructures - Google Patents

Abstract

A microstructure shooting device is provided. The microstructure shooting device according to an embodiment of the present invention includes a hollow body, an upper cover portion coupled to one side of the body and forming at least one through hole, and a lower cover portion coupled to the other side of the body and forming a plurality of openings. A housing including; A pressing member provided in the housing to press the microstructure including the biocompatible material toward the plurality of openings; A receiving portion that accommodates the liquid drug and has an outlet formed at the lower side thereof; And a button unit for sequentially or independently pressing the pressing member and the receiving unit by an external force. Here, the liquid drug is applied on the surface of the skin before or after the microstructure is implanted into the skin.

Description

Shooting device for microstructures

The present invention relates to a microstructure shooting device.

Numerous drugs and therapeutics have been developed for the treatment of diseases, but in delivering drugs into the body, problems passing through biological barriers (e.g., skin, oral mucosa, and brain-vascular barriers) and problems of drug delivery efficiency Remains to be improved.

Drugs are generally administered orally in tablet form or capsule form, but for reasons such as digestion or absorption in the gastrointestinal tract or being lost by the mechanism of the liver, such drugs cannot be effectively delivered only with the above administration method. In addition, some drugs cannot effectively diffuse through the intestinal mucosa. In addition, patient compliance is also a problem, for example, in the case of critically ill patients who have to take drugs at specific intervals or who cannot take drugs.

In drug delivery, another common technique is to use a conventional needle. While this method is effective compared to oral administration, there are problems of causing pain at the injection site, local damage to the skin, bleeding, and disease infection at the injection site.

In order to solve the above problems, various microstructures including microneedles have been developed. Microstructures developed to date have been mainly used for drug delivery in vivo, blood collection, and detection of analytes in the body.

Existing biodegradable microstructures or microstructures required a separate adhesive sheet to adhere to the skin and fix it for a long time. Due to the use of the adhesive sheet, the user may feel a foreign body, and an allergic reaction may occur. In addition, there is a problem that there is a limitation in application to joints with severe movement, skin with curves, and skin with hair.

On the other hand, in the case of a drug that is difficult to form into a microstructure, a method of additionally applying the drug to the skin before or after the implantation of the microstructure is taken.

However, in addition to the shooting device for implanting the microstructure into the skin, a separate means for applying the drug is required.

Moreover, when a separate tool is used to apply the microstructure and other drugs, there is a difference between the time when the microstructure is implanted into the skin and the time when other drugs are applied to the surface of the skin, so that the effect is inferior.

In order to solve this problem, there is an increasing need for devices for simultaneously using microstructures and other drugs.

KR 1782752 B1

In order to solve the problems of the prior art as described above, an embodiment of the present invention is to provide a microstructure shooting device capable of simultaneously applying a microstructure and a liquid drug.

According to an aspect of the present invention for solving the above problems, a hollow body, an upper cover portion coupled to one side of the body and having at least one through hole formed therein, and a plurality of openings are coupled to the other side of the body. A housing including a lower cover portion formed; A pressing member provided in the housing to press the microstructure including the biocompatible material toward the plurality of openings; A receiving portion that accommodates the liquid drug and has an outlet formed at the lower side thereof; And a button unit for sequentially or independently pressing the pressing member and the receiving unit by an external force. Here, the liquid drug is applied on the surface of the skin before or after the microstructure is implanted into the skin.

In one embodiment, when the button portion is pressed to a first depth, the receiving portion is pressed so that the liquid drug is discharged to the surface of the skin, and when pressed to a second depth greater than the first depth, the microstructure is implanted into the skin. It is possible to pressurize the pressing member so as to be.

In one embodiment, the pressing member includes a plate-shaped first plate; And a plurality of pressing protrusions protruding from the first plate toward the lower cover portion and having the microstructure formed at one end thereof.

In one embodiment, the button portion pressing portion protruding outward through the first through hole of the housing; A plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the receiving part by an external force; And a protrusion formed protruding from the second plate toward the pressing member and spaced apart from the pressing member at a predetermined interval.

In one embodiment, the button portion includes a first button portion for pressing the receiving portion and a second button portion for pressing the pressing member, and the first button portion is pushed outward through the first through hole of the housing part; And a plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the receiving part by an external force. Here, the second button portion is formed extending from the pressing member toward the second plate, and may protrude outward through the second through hole of the upper cover portion and the through hole of the second plate.

In one embodiment, the microstructure shooting device includes a first elastic member disposed between the pressing member and the lower cover portion; And a second elastic member disposed between the pressing member and the button part.

In one embodiment, when the button portion is pressed to a first depth, the pressing member is pressed so that the microstructure is implanted into the skin, and when pressed to a second depth greater than the first depth, the liquid drug is transferred to the surface of the skin. It is possible to pressurize the receiving portion to be discharged.

In one embodiment, the pressing member includes a plate-shaped first plate; A plurality of pressing protrusions protruding from the first plate toward the lower cover portion and having the microstructure formed at one end; And an extension part extending one side of the first plate and the button part.

In one embodiment, the pressing member is formed to protrude toward the first plate from the lower cover portion, the stop portion formed to be spaced apart from the first plate by a predetermined distance; And a locking part provided at one end of the extension part and inserted into the extension part by the support force of the first plate by the stopping part. Here, the gap between the first plate and the button part may be reduced by the insertion of the locking part.

In one embodiment, the button portion pressing portion protruding outward through the first through hole of the housing; A plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the pressing member by an external force; And a protrusion formed protruding from the second plate toward the receiving portion and spaced apart from the receiving portion at a predetermined interval.

In one embodiment, the button portion includes a first button portion for pressing the receiving portion and a second button portion for pressing the pressing member, and the first button portion is pushed outward through the first through hole of the housing part; And a plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the pressing member by an external force. Here, the second button portion is formed extending from the receiving portion toward the second plate, and may protrude outward through the through hole of the second plate.

In one embodiment, the microstructure shooting device includes a first elastic member disposed between the pressing member and the lower cover portion; And a second elastic member disposed between the receiving part and the lower cover part.

In an embodiment, the microstructure shooting device further includes an opening and closing unit provided below the receiving unit to discharge or block the liquid drug to at least one of the plurality of openings as the receiving unit is pressed and moved toward the plurality of openings. Can include.

In one embodiment, the receiving portion is a storage unit that receives the liquid drug and the outlet is formed on the bottom surface; And a flow path connecting at least one of the plurality of openings from the outlet. Here, the storage unit may be disposed to be movable through the outlet outside the flow path.

In one embodiment, the microstructure shooting device is a blocking portion formed larger than the width of the outlet; And a support portion extending from a lower side of the blocking portion to the lower cover portion.

In one embodiment, the plurality of openings may include a plurality of first openings through which the microstructure is shot and at least one second opening through which the liquid drug is discharged.

In an embodiment, at least one flow path having a groove shape having a predetermined depth may be formed in the lower cover part in communication with the at least one second opening.

In one embodiment, the plurality of first openings and the at least one second opening may be arranged in an array form, and the at least one second opening may be arranged between the plurality of first openings.

In one embodiment, the lower cover portion may have a sidewall formed along the outer periphery of the lower surface thereof.

The microstructure shooting device according to an embodiment of the present invention applies a liquid drug on the surface of the skin immediately before implanting the microstructure into the skin, so that the drug contained in the microstructure can be delivered deeper to the skin. It can improve the efficacy of drug delivery.

In addition, the microstructure shooting device according to an embodiment of the present invention uses the microstructure and the liquid drug together, so that the microstructure and the liquid drug can be applied to the skin substantially at the same time. The difference can be reduced.

In addition, since the microstructure shooting device according to an embodiment of the present invention applies a drug that is difficult to manufacture as a microstructure in a liquid form together with the microstructure, it is possible to diversify the types of delivery drugs.

In addition, the microstructure shooting device according to an embodiment of the present invention can maximize drug delivery efficiency by improving the dissolution rate of the microstructure by applying a material that helps dissolution of the microstructure to the skin before and after implantation of the microstructure. have.

1 is a cross-sectional view showing a microstructure shooting device according to a first embodiment of the present invention,
2 is a cross-sectional view showing a state in which a button portion is pressed to a first depth in FIG. 1;
3 is a cross-sectional view showing a state in which the button portion is pressed to a second depth in FIG. 2;
4 is a plan view showing various examples of a lower cover part in FIG. 1;
5 is a perspective view showing various examples in which a flow path is formed in a lower cover portion in FIG. 1;
6 is a perspective view showing an example of a lower cover portion in FIG. 1;
7 is a perspective view showing another example of the lower cover portion in FIG. 1;
8 is a perspective view showing another example of the lower cover portion,
9 is a cross-sectional view showing a microstructure shooting device according to a second embodiment of the present invention;
10 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 9;
11 is a cross-sectional view showing a state in which the second button portion is pressed in FIG. 9;
12 is a cross-sectional view showing a microstructure shooting device according to a third embodiment of the present invention;
13 is a cross-sectional view showing a state in which a button portion is pressed to a first depth in FIG. 12;
14 is a cross-sectional view showing a state in which a button portion is pressed to a second depth in FIG. 12;
15 is a cross-sectional view showing a microstructure shooting device according to a fourth embodiment of the present invention;
16 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 15, and,
17 is a cross-sectional view illustrating a state in which the second button portion is pressed in FIG. 15.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily implement the present invention. The present invention may be implemented in various different forms and is not limited to the embodiments described herein. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and the same reference numerals are assigned to the same or similar components throughout the specification.

Hereinafter, a microstructure shooting device according to an embodiment of the present invention will be described in more detail with reference to the drawings. 1 is a cross-sectional view showing a microstructure shooting device according to a first embodiment of the present invention, FIG. 2 is a cross-sectional view showing a state in which a button portion is pressed to a first depth in FIG. 1, and FIG. 3 is a button in FIG. It is a cross-sectional view showing a state in which the part is pressed to a second depth.

Referring to FIGS. 1 to 3, the microstructure shooting device 100 includes a housing 110, a pressing member 120, a receiving part 130, an opening/closing part 140, and a button part 150.

This microstructure shooting device 100 is for shooting so that the microstructure 10 is implanted into the skin 1 by pressure applied from the outside. Here, “shooting” means that the microstructure 10 is separated from the microstructure shooting device 100 and moves forward.

The present invention is to apply a liquid drug 20 that is difficult to manufacture into the microstructure 10 together with the shooting of the microstructure 10 to the skin 1. That is, the microstructure shooting device 100 is for applying the liquid drug 20 on the surface of the skin 1 before or after the microstructure 10 is implanted into the skin. In the present specification, applying the liquid drug 20 before the microstructure 10 corresponds to the first and second embodiments, and applying the liquid drug 20 after the microstructure 10 This corresponds to the third and fourth embodiments.

Drugs that can be used for the microstructure 10 in the present invention are not particularly limited. For example, the drugs include chemical drugs, protein drugs, peptide drugs, nucleic acid molecules for gene therapy, nanoparticles, functional cosmetic active ingredients and cosmetic ingredients.

In addition, drugs that can be used in the present invention include, for example, anti-inflammatory drugs, analgesics, anti-arthritis drugs, antispasmodics, antidepressants, antipsychotic drugs, tranquilizers, anti-anxiety drugs, drug antagonists, anti-Parkinosis drugs, cholinergic agonists, Anticancer drugs, antiangiogenic drugs, immunosuppressants, antivirals, antibiotics, appetite suppressants, analgesics, anticholinergics, antihistamines, antimigraine drugs, hormones, coronary blood vessels, cerebrovascular or peripheral vasodilators, contraceptives, antithrombotic drugs, diuretics , Antihypertensive agents, cardiovascular disease treatments, cosmetic ingredients (eg, anti-wrinkle agents, skin aging inhibitors, and skin whitening agents), but are not limited thereto.

In addition, the material forming the microstructure 10 in the present invention includes a biocompatible or biodegradable material. As used herein, the term "biocompatible substance" refers to a substance that is not toxic to the human body, is chemically inactive, and is not immunogenic. In the present specification, the term "biodegradable material" refers to a material that can be degraded by body fluids or microorganisms in a living body.

In this case, the microstructure 10 may be formed by spotting the viscous composition of the above drugs. Here, the term "viscous composition" refers to a composition having the ability to form a microstructure by changing the shape.

The liquid drug 20 functions as an adjuvant to aid in dissolution or drug delivery of the microstructure 10. By applying such a liquid drug 20 to the skin 1 before or after the implantation of the microstructure 10, the microstructure 10 dissolves more rapidly in the skin 1, or the microstructure 10 ) It is possible to maximize the delivery efficiency of the drug to the skin (1), thus reducing the drug delivery time by the microstructure (10).

In addition, the liquid drug 20 may be a drug that is difficult to form into the microstructure 10 in the same manner as spotting by a viscous composition. For example, the liquid drug 20 may include not only medical drugs, but also cosmetic ampoules. Accordingly, the type of drug delivered to the skin 1 can be diversified, not limited to the microstructure 10 as a medium for delivering the drug.

The microstructure shooting device 100 according to the first embodiment of the present invention is for applying the liquid drug 20 to the skin 1 and then implanting the microstructure 10 onto the skin 1. To this end, when the button unit 150 is pressed to the first depth, as a first pressing step, the receiving unit 130 is pressed so that the liquid drug 20 is discharged to the surface of the skin 1, and When pressed, the pressing member 120 may be pressed so that the microstructure 10 is implanted into the skin 1 as a second pressing step. Here, the second depth may be greater than the first depth.

The housing 110 may include an upper cover portion 112, a lower cover portion 114 and a body 116.

The upper cover part 112 is coupled to the upper side of the body 116, and a through hole 112a may be formed. The through hole 112a may be inserted so that one side of the button unit 150 protrudes outward, as described later.

The lower cover portion 114 is coupled to the lower side of the body 116 and a plurality of openings 114a and 114b may be formed. The openings 114a and 114b include a plurality of first openings 114a through which the microstructure 10 is shot, and at least one second opening 114b through which the liquid drug 20 is discharged. Here, the lower cover portion 114 may have a flow path 114c communicating with the second opening 114b at a lower surface thereof. Further, the lower cover portion 114 may have sidewalls 114d formed along the outer periphery of its lower surface.

The body 116 may be formed in a hollow shape. That is, the body 116 may accommodate the pressing member 120, the receiving portion 130, the opening and closing portion 140, and the button portion 150 therein.

The pressing member 120 is provided in the housing 110 to press the microstructure 10 toward the first opening 114a, a plurality of pressing protrusions 122, a first plate 124, and a first elastic member (126) may be included.

The pressing protrusion 122 may be provided in plurality, and may be formed to protrude toward the lower cover portion 114 from the first plate 124. Here, the pressure protrusion 122 may have a microstructure 10 formed at one end facing toward the lower cover portion 114.

The first plate 124 has a plate shape and may be disposed to be movable in a vertical direction within the body 116. The first plate 124 may have a plurality of pressing protrusions 122 formed on a surface of the first plate 124 facing the lower cover portion 114.

The first elastic member 126 may be disposed between the first plate 124 and the lower cover portion 114. The first elastic member 126 may restore the first plate 124 pressed by an external force to its original position. Here, the first elastic member 126 may be provided outside the pressing protrusion 122, but is not particularly limited thereto.

The receiving unit 130 is for receiving the liquid drug 20 and may include a storage unit 132 and a flow path unit 136.

The storage unit 132 has a certain accommodation space formed therein, and may accommodate the liquid drug 20. The storage unit 132 may have a discharge port 134 for discharging the liquid drug 20 on its bottom surface.

The flow path part 136 may connect at least one second opening 114b from the outlet 134 of the storage part 132. That is, the flow path part 136 may be provided under the storage part 132 and the outside thereof may be disposed to be inserted into the discharge port 134. At this time, the flow path part 136 has one end formed only to the approximately center of the discharge port 134 and does not extend to the inner bottom surface of the storage part 132.

Here, the storage unit 132 may be disposed to be movable in a vertical direction from the outside of the flow path unit 136 through the outlet 134.

The opening/closing part 140 is for discharging or blocking the liquid drug 20 from the receiving part 130, and may include a blocking part 142 and a support part 144.

The blocking portion 142 may be formed larger than the width of the outlet 134 formed on the lower surface of the storage unit 132. That is, the blocking unit 142 may be disposed on the upper surface of the discharge port 134 to block the liquid drug 20 from being discharged.

The support part 144 may extend from the lower side of the blocking part 142 to the lower cover part 114. That is, the support part 144 may be disposed to be coupled to each of the blocking part 142 and the lower cover part 114. Here, the support part 144 may be disposed inside the flow path part 136.

At this time, when the receiving part 130 is pressurized and moves vertically toward the lower cover part 114, the bottom surface of the blocking part 142 and the storage part 132 is spaced apart, so that the liquid drug 20 is at least one It can be discharged through the second opening (114b).

The button portion 150 is for sequentially pressing the pressing member 120 and the receiving portion 130 by an external force, and the pressing portion 152, the second plate 154, the protruding portion 156, and the second elastic member (158) may be included.

The pressing part 152 may protrude outward through the through hole 112a of the housing 110. The pressing part 152 may be a part to which an external force is applied by a user.

The second plate 154 may be formed on one side of the pressing portion 152 and may be disposed in the housing 110 to be movable in a vertical direction. Here, the second plate 154 is formed in a plate shape and may press the receiving portion 130 by an external force through the pressing portion 152. That is, the second plate 154 may be directly or indirectly connected to the upper end of the storage unit 132 through one surface facing the receiving unit 130.

The protrusion 156 may be formed to protrude toward the first plate 124 from the lower surface of the second plate 154. In this case, the protrusions 156 may be formed to be spaced apart from the first plate 124 at a predetermined interval. Therefore, the external force is not transmitted to the first plate 124 until the protrusion 156 reaches the first plate 124. That is, the gap between the protruding portion 156 and the first plate 124 may correspond to the first depth due to the primary pressing of the pressing portion 152.

The second elastic member 158 may be disposed between the first plate 124 and the second plate 154. The second elastic member 158 may restore the second plate 154 pressed by an external force to its original position. Here, the second elastic member 158 may be provided outside the storage unit 132, but is not particularly limited thereto.

Hereinafter, the configurations of the openings 114a and 114b and the flow path 114c of the lower cover portion 114 will be described in more detail.

FIG. 4 is a plan view showing various examples of a lower cover part in FIG. 1, FIG. 5 is a perspective view showing various examples in which a flow path is formed in the lower cover part in FIG. 1, and FIG. 6 is an example of the lower cover part in FIG. 1 One perspective view, FIG. 7 is a perspective view showing another example of the lower cover portion in FIG. 1, and FIG. 8 is a perspective view showing another example of the lower cover portion.

Referring to FIG. 4, a plurality of first openings 114a and at least one second opening 114b may be arranged in an array form on a lower surface of the lower cover portion 114. That is, each of the first openings 114a and the second openings 114b may be disposed at equal intervals in the first direction and may be disposed at equal intervals in the second direction perpendicular to the first direction. In this case, the second opening 114b may be disposed between the first opening 114a.

For example, the second opening 114b may be formed in the center of the four first openings 114a (see FIG. 4(a)). As another example, only one second opening 114b may be formed in the center of the lower cover portion 1141 (see FIG. 4(b)). As another example, the second opening 114b may be formed at a square corner of the lower cover portion 1142 (see FIG. 4(c)). In this case, the first opening 114a may be formed in a cross shape with respect to the center. Here, the microstructure 10 can be shot through the first opening 114a, and the liquid drug 20 can be discharged through the second opening 114b.

Referring to FIG. 5, the lower cover portions 1143 to 1145 may have at least one flow path having a groove shape having a predetermined depth communicating with at least one second opening 114b.

As an example, the flow path 1143c may be formed in both directions in the first direction and the second direction around the second opening 114b on the lower surface of the lower cover portion 1143 (see FIG. 5(a)). As shown in FIG. 7, the flow path 1147c may be formed in a groove shape having a predetermined depth from the lower surface of the lower cover portion 1147. Alternatively, as shown in Figure 6, the flow path (1146c) is formed in only one of the first direction and the second direction around the second opening (114b) on the lower surface of the lower cover (1146). May be.

At this time, the lower cover portion 1143 may have a side wall 1143d formed along the outer periphery so that the liquid drug 20 does not flow out of the microstructure shooting device 100 (see FIG. 5(a)). .

As another example, the flow path 1144c may be formed in a first direction and a second direction around one second opening 114b formed in the center of the lower cover part 1144 (see FIG. 5(b)). ). That is, the flow path 1144c may be formed in a cross shape on the lower surface of the lower cover portion 1144. Thereby, the liquid drug 20 can be delivered from the second opening 114b to the four sides of the lower cover 1144.

As another example, the lower cover portions 1145 and 1148 may have sidewalls 1145d and 1148d along the outer periphery of their lower surfaces instead of forming a groove-shaped flow path (see FIGS. 5(c) and 8). ). That is, in the lower cover portions 1145 and 1148, flow paths 1145c and 1148c may be formed in a space corresponding to the height of the sidewalls 1145d and 1148d. As a result, the flow path is formed over the entire lower surface of the microstructure shooting device 100, so that the liquid drug 20 can be more efficiently applied to the skin 1.

Referring to FIG. 2, when the button unit 150 is pressed to the first depth, the receiving unit 130 may be pressed by the second plate 154 to vertically move toward the lower cover unit 114. At this time, the bottom surface of the storage unit 132 is positioned equal to or lower than one end of the flow path unit 136. Accordingly, since the blocking part 142 is spaced apart from the bottom surface of the storage part 132, the liquid drug 20 may be discharged to the flow path part 136 through the discharge port 134.

As a result, the liquid drug 20 can be discharged through at least one second opening 114b communicating with the flow path part 136. Accordingly, the discharged liquid drug 20 ′ may be applied on the surface of the skin 1 through the flow path 114c. Here, the button unit 150 may be maintained at the first depth until all of the liquid drug 20 accommodated in the storage unit 132 is discharged.

In this case, the protrusion 156 formed on the lower surface of the second plate 154 may reach the first plate 124. That is, before the protruding portion 156 reaches the first plate 124, the pressing member 120 is not pressed, and only the receiving portion 130 is pressed by the second plate 154, so that the liquid drug 20' ) May be applied to the surface of the skin 1 first.

Referring to FIG. 3, when the button part 150 is pressed further to the second depth in a state in which the liquid drug 20 is applied to the surface of the skin 1, the protrusion 156 becomes the first plate 124 Since the reached state, the external force of the button unit 150 is transmitted to the first plate 124, the first plate 124 can be pressed.

In this way, as the first plate 124 is pressed, the pressing protrusion 122 moves vertically toward the lower cover portion 114, so that the microstructure 10 protrudes to the outside of the first opening 114a so that the skin 1 ) Can be implanted.

Thereby, since the liquid drug improves the dissolution rate of the microstructure, the drug contained in the microstructure can be delivered deeper to the skin, and thus the efficacy of drug delivery can be improved.

At this time, the microstructure shooting device of the present invention can independently press the receiving portion and the pressing member by having two button portions. The microstructure shooting device 200 according to the second embodiment of the present invention may include a first button part and a second button part 256. Here, the same components as in the first embodiment are denoted by the same reference numerals, and detailed descriptions thereof are omitted.

9 is a cross-sectional view showing a microstructure shooting device according to a second embodiment of the present invention, FIG. 10 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 9, and FIG. 11 is a second button in FIG. 9 It is a cross-sectional view showing a state in which the additional pressure is pressed.

Referring to FIG. 9, the microstructure shooting device 200 may include a housing 210, a pressing member 120, a receiving part 130, an opening/closing part 140, and a button part 250. Here, the pressing member 120, the receiving portion 130, and the opening/closing portion 140 are the same as the microstructure shooting device 100 of the first embodiment.

The housing 210 includes an upper cover portion 212, a lower cover portion 114, and a body 116, and is the same as the housing 110 of the first embodiment except for the second through hole 212b.

The upper cover part 212 may further include a second through hole 212b at a position corresponding to the second button part 256 in addition to the first through hole 112a corresponding to the pressing part 152.

The button unit 250 may include a first button unit and a second button unit 256. Here, the first button portion is for pressing the receiving portion 130 and may include a pressing portion 152, a second plate 254 and a second elastic member 158.

That is, the first button portion is the same as the button portion 150 of the first embodiment except for the third through hole 254a and the protrusion portion 156. Here, in the second plate 254, a third through hole 254a may be formed at a position corresponding to the first through hole 212b.

The second button part 256 is for pressing the pressing member 120, and may extend from the first plate 124 toward the second plate 154. That is, the second button part 256 may protrude outward through the second through hole 212b of the upper cover part 212 and the third through hole 254a of the second plate 254.

Referring to FIG. 10, when the pressing portion 152 of the first button portion is pressed, the receiving portion 130 may be pressed by the second plate 154 and vertically move toward the lower cover portion 114. At this time, the bottom surface of the storage unit 132 is positioned equal to or lower than one end of the flow path unit 136. Accordingly, since the blocking part 142 is spaced apart from the bottom surface of the storage part 132, the liquid drug 20 may be discharged to the flow path part 136 through the discharge port 134.

As a result, the liquid drug 20 can be discharged through at least one second opening 114b communicating with the flow path part 136. Accordingly, the discharged liquid drug 20 ′ may be applied on the surface of the skin 1 through the flow path 114c. Here, the pressing unit 152 may be held until all the liquid drug 20 accommodated in the storage unit 132 is discharged.

Referring to FIG. 11, when the second button portion 256 is pressed while the liquid drug 20 is applied to the surface of the skin 1, the first plate 124 may be pressed. In this case, the first button portion may be maintained in a previous state.

That is, the receiving portion 130 may be maintained as it is without moving downward. Here, although not shown in the drawing, a flange or plate for supporting the second elastic member 158 may be further provided in order to maintain the second elastic member 158 in a compressed state.

In this way, as the first plate 124 is pressed, the pressing protrusion 122 moves vertically toward the lower cover portion 114, so that the microstructure 10 protrudes to the outside of the first opening 114a so that the skin 1 ) Can be implanted.

As a result, since the microstructure and the liquid drug can be applied to the skin at the same time, the difference in time between the delivery of the drug due to each can be reduced, and two types of drugs can be used individually with one device. Convenience can be provided.

On the other hand, the microstructure shooting device 300 according to the third embodiment of the present invention is for applying the liquid drug 20 to the skin 1 after implanting the microstructure 10 on the skin 1. Here, when the liquid drug 20 dissolves the microstructure 10 at a high rate, it may be applied on the surface of the skin 1 after implantation of the microstructure 10.

To this end, when the button unit 350 is pressed to the first depth, it is a first pressing step, and when the microstructure 10 is implanted into the skin 1, the pressing member 320 is pressed, and when pressed to the second depth, 2 As a secondary pressing step, the receiving portion 330 may be pressed so that the liquid drug 20 is discharged to the surface of the skin 1. Here, the second depth may be greater than the first depth.

12 is a cross-sectional view showing a microstructure shooting device according to a third embodiment of the present invention, FIG. 13 is a cross-sectional view showing a state in which a button portion is pressed to a first depth in FIG. 12, and FIG. 14 is a button in FIG. It is a cross-sectional view showing a state in which the part is pressed to a second depth.

Referring to FIG. 12, the microstructure shooting device 300 includes a housing 310, a pressing member 320, a receiving part 330, an opening and closing part 340, and a button part 350.

The housing 310 may include an upper cover portion 312, a lower cover portion 314 and a body 316. Here, since the housing 310 is the same as the housing 110 of the first embodiment, a detailed description will be omitted.

The pressing member 320 may include a pressing protrusion 322, a first plate 324, a first elastic member 326, a stopping part 327, an extension part 328, and a locking part 329. Here, since the pressing protrusion 322 and the first elastic member 326 are the same as the pressing protrusion 122 and the first elastic member 126 of the first embodiment, a detailed description will be omitted. However, the pressing protrusion 322 may be formed shorter than the pressing protrusion 122 of the first embodiment because the distance vertically moving toward the lower cover 314 is shorter than the pressing protrusion 122 of the first embodiment.

The first plate 324 may have a plate shape and may be disposed to be movable in a vertical direction within the body 316. The first plate 324 may have a plurality of pressing protrusions 322 formed on one surface facing the lower cover 314.

In addition, the first plate 324 may have a groove portion 324a formed on one surface facing the second plate 354. Here, the groove part 324a may be formed to have a width corresponding to the width of the extension part 328 and may be formed to have a depth corresponding to a distance in which the receiving part 330 moves vertically. That is, in the groove portion 324a, one end of the extension portion 328 may be inserted when the button portion 350 is secondarily pressed.

The stopping part 327 may be formed to protrude toward the first plate 324 from the lower cover part 314. In this case, the blocking portion 327 may be formed to be spaced apart from the first plate 324 by a predetermined interval. The stopping part 327 may block the pressing of the first plate 324. That is, the stopping part 327 may prevent the first plate 324 from moving downward when the button part 350 is pressed for the second time.

The extension 328 may extend the first plate 324 and the second plate 354. For example, the extension part 328 may be formed to extend from the second plate 354 toward the first plate 324. Accordingly, when the button unit 350 is pressed to the first depth, the first plate 324 may also be pressed in conjunction with the pressing of the second plate 354.

The locking part 329 may be provided at one end of the first plate 324 in the extension part 328. Here, the locking part 329 supports the two ends of the extension part 328 when the button part 350 is pressed to the first depth. Therefore, the extension part 328 may maintain a constant interval between the second plate 354 and the first plate 324.

In addition, when the button portion 350 is pressed to the second depth, the locking portion 329 may be inserted into the extension portion 328 by the supporting force of the first plate 324. That is, when the button portion 350 is pressed to the second depth, the first plate 324 is no longer moved downward by the stopping portion 327, and a supporting force is generated. The locking portion 329 may be inserted into the extension portion 328 by the holding force thus generated, and thus, one side of the extension portion 328 may be inserted into the groove portion 324a. Accordingly, the distance between the first plate 324 and the second plate 354 may be reduced.

Here, the extension portion 328 has been illustrated and described as extending from the second plate 354 toward the first plate 324, but is not limited thereto. That is, the extension part 328 may be formed to extend from the first plate 324 toward the second plate 354. In this case, the groove portion 324a may be formed on the side of the second plate 354, and the locking portion 329 may be provided on the side of the second plate 354 in the extension portion 328.

The accommodation part 330 may include a storage part 332, a flow path part 336, and a second elastic member 338. Here, the accommodating portion 330 is the same as the accommodating portion 130 of the first embodiment except for the second elastic member 338, so a detailed description thereof is omitted. However, since the distance in which the accommodation part 330 moves vertically toward the lower cover part 314 is shorter than the accommodation part 130 of the first embodiment, the flow path part 336 is longer than the flow path part 136 of the first embodiment. Can be short.

The second elastic member 338 may be disposed between the storage part 332 and the lower cover part 314. The second elastic member 338 may restore the storage unit 132 pressed by an external force to its original position. Here, the second elastic member 338 may be provided outside the flow path part 336, but is not particularly limited thereto.

The opening and closing part 340 may include a blocking part 342 and a support part 344. Here, since the opening/closing part 340 is the same as the opening/closing part 140 of the first embodiment, a detailed description will be omitted. However, similar to the flow path portion 336, the support portion 344 may be shorter in length than the support portion 144 of the first embodiment.

The button portion 350 may include a pressing portion 352, a second plate 354, and a protruding portion 356. Here, the button portion 350 is the same as the button portion 150 of the first embodiment except for the protrusion portion 356, a detailed description thereof will be omitted.

The protrusion 356 may be formed to protrude from the second plate 354 toward the receiving portion 330. In this case, the protrusion 356 may be formed to be spaced apart from the receiving portion 330 at a predetermined interval. Therefore, the external force is not transmitted to the receiving portion 330 until the protruding portion 356 reaches the receiving portion 330. That is, the distance between the protruding portion 356 and the receiving portion 330 may correspond to a first depth due to the first pressing of the pressing portion 352.

Referring to FIG. 13, when the button portion 350 is pressed to the first depth, the first plate 324 is pressed by the second plate 354 through the extension portion 328 to the lower cover portion 314 side. Can move vertically. In this case, the locking portions 329 may be supported on both sides of the groove portion 423 of the first plate 324. Accordingly, the first plate 324 is pressed simultaneously with the second plate 354 to vertically move.

In this way, as the first plate 324 is pressed, the pressing protrusion 322 vertically moves toward the lower cover 314, so that the microstructure 10 protrudes to the outside of the first opening 314a so that the skin 1 Can be implanted in

In this case, the protrusion 356 formed on the lower surface of the second plate 354 may reach the receiving portion 330. That is, before the protruding portion 356 reaches the storage portion 332, the receiving portion 330 is not pressed, and only the first plate 324 is pressed by the second plate 354, so that the microstructure 10 is It can be implanted on the surface of the skin 1 first.

In addition, the lower surface of the first plate 324 may reach the blocking portion 327. That is, the first plate 324 is no longer pressed by the blocking portion 327 and may maintain the corresponding position.

Referring to FIG. 14, in a state in which the microstructure 10 is implanted into the skin 1, when the button portion 350 is further pressed to the second depth, the protrusion 356 reaches the receiving portion 330 Therefore, the external force of the button portion 350 is transmitted to the receiving portion 330 through the protruding portion 356 so that the receiving portion 330 may be pressed.

In this way, as the receiving part 330 is pressed, the storage part 332 may vertically move toward the lower cover part 314. At this time, the bottom surface of the storage unit 332 is positioned equal to or lower than one end of the flow path unit 336. Therefore, since the blocking part 342 is spaced apart from the bottom surface of the storage part 332, the liquid drug 20 may be discharged to the flow path part 336 through the discharge port 334.

As a result, the liquid drug 20 can be discharged through at least one second opening 314b communicating with the flow path part 336. Accordingly, the discharged liquid drug 20 ′ may be applied on the surface of the skin 1 through the flow path 114c. Here, the button unit 350 may be maintained at the second depth until all of the liquid drug 20 accommodated in the storage unit 232 is discharged.

Thereby, since a drug, which is difficult to manufacture into a microstructure, is applied in a liquid form together with the microstructure, the kinds of drugs to be delivered can be diversified.

At this time, the microstructure shooting device of the present invention can independently press the receiving portion and the pressing member by having two button portions. To this end, the microstructure shooting device 400 according to the fourth embodiment of the present invention may include a first button part and a second button part 456. Here, the same components as in the third embodiment are denoted by the same reference numerals, and detailed descriptions thereof are omitted.

15 is a cross-sectional view showing a microstructure shooting device according to a fourth embodiment of the present invention, FIG. 16 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 15, and FIG. 17 is a second button in FIG. 15 It is a cross-sectional view showing a state in which the additional pressure is pressed.

Referring to FIG. 15, the microstructure shooting device 400 may include a housing 410, a pressing member 420, a receiving part 330, an opening/closing part 340, and a button part 450. Here, the accommodating portion 330 and the opening and closing portion 340 are the same as the microstructure shooting device 300 of the third embodiment.

The housing 410 includes an upper cover portion 412, a lower cover portion 314, and a body 316, and is the same as the housing 310 of the third embodiment except for the second through hole 412b.

In addition to the first through hole 312a corresponding to the pressing part 452, the upper cover 412 may further have a second through hole 412b formed at a position corresponding to the second button part 456.

The pressing member 420 is the same as the pressing member 320 of the third embodiment except for the first plate 424 and the extension part 428.

Compared to the first plate 324 of the third embodiment, the first plate 424 does not have a groove portion 324a and an extension portion 428 may be connected. That is, the extension part 428 may be coupled to both sides of the first plate 424 and the second plate 454.

The button part 450 may include a first button part and a second button part 456. Here, the first button portion is for pressing the pressing member 420 and may include a pressing portion 352, a second plate 454, and a second elastic member 358.

That is, the first button portion is the same as the button portion 350 of the third embodiment except for the third through hole 454a and the protruding portion 356. Here, in the second plate 454, a third through hole 454a may be formed at a position corresponding to the first through hole 312b.

The second button portion 456 is for pressing the receiving portion 330, and may be formed to extend from the receiving portion 330 toward the second plate 454. That is, the second button part 456 may protrude outward through the second through hole 412b of the upper cover part 412 and the third through hole 454a of the second plate 454.

Referring to FIG. 16, when the pressing portion 352 of the first button portion is pressed, the first plate 424 is pressed by the second plate 454 through the extension portion 428 to the lower cover portion 314 side. You can move vertically.

In this way, by pressing the first plate 424, the pressing protrusion 322 may vertically move toward the lower cover portion 314. Accordingly, the microstructure 10 may protrude to the outside of the first opening 314a and may be implanted into the skin 1.

Referring to FIG. 17, when the second button portion 456 is pressed while the microstructure 10 is implanted on the skin 1, the receiving portion 330 is pressed and moves vertically toward the lower cover portion 314. I can. Here, the first button portion may be maintained in a previous state.

At this time, the bottom surface of the storage unit 332 is positioned equal to or lower than one end of the flow path unit 336. Therefore, since the blocking part 342 is spaced apart from the bottom surface of the storage part 332, the liquid drug 20 may be discharged to the flow path part 336 through the discharge port 334.

As a result, the liquid drug 20 can be discharged through at least one second opening 314b communicating with the flow path part 336. Therefore, the discharged liquid drug 20 ′ may be applied on the surface of the skin 1 through the flow path 314c.

As a result, since the microstructure and the liquid drug can be applied to the skin at the same time, the difference in time between the delivery of the drug due to each can be reduced, and two types of drugs can be used individually with one device. Convenience can be provided.

Although an embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiment presented in the present specification, and those skilled in the art who understand the spirit of the present invention can add components within the scope of the same idea. It will be possible to easily propose other embodiments by changing, deleting, adding, etc., but it will be said that this is also within the spirit scope of the present invention.

100,200,300,400: Micro structure shooting device
110,210,310: housing 112,212,312: upper cover
114,314: lower cover part 116,316: body
120,320,420: pressing member 122,322: pressing protrusion
124,324,424: first plate 126,326: first elastic member
130,330: accommodation unit 132,332: storage unit
134,334: outlet 136,336: flow path
140,340: opening and closing part 142,342: blocking part
144,344: support part 150,250,350,450: button part
152,352: pressing part 154,254,354,454: second plate
156,356: protrusion 158,338: second elastic member
256,456: second button part 327: stopping part
328,428: extension part 329: locking part
10: microstructure 20: liquid drug

Claims (19)

A housing including a hollow body, an upper cover portion coupled to one side of the body and having at least one through hole formed therein, and a lower cover portion coupled to the other side of the body and forming a plurality of openings;
A pressing member provided in the housing, made of a biocompatible material, and pressurizing a microstructure that is dissolved in a living body toward the plurality of openings;
A receiving portion that accommodates the liquid drug and has an outlet formed at the lower side thereof; And
Includes; a button unit for sequentially or independently pressing the pressing member and the receiving unit by an external force,
The liquid drug is a drug that is not manufactured in the form of the microstructure by a viscous composition, and is applied on the surface of the skin before or after implanting the microstructure into the skin. The method of claim 1,
When the button portion is pressed to the first depth, the receiving portion is pressed so that the liquid drug is discharged to the surface of the skin,
A microstructure shooting device for pressing the pressing member so that the microstructure is implanted into the skin when pressed to a second depth greater than the first depth. The method of claim 2,
The pressing member,
A plate-shaped first plate; And
Microstructure shooting device comprising a; a plurality of pressing protrusions protruding from the first plate toward the lower cover portion, the microstructure is formed at one end. The method of claim 2,
The button part,
A pressing part protruding outward through the first through hole of the housing;
A plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the receiving part by an external force; And
And a protrusion formed protruding from the second plate toward the pressing member and spaced apart from the pressing member at a predetermined interval. The method of claim 1,
The button portion includes a first button portion pressing the receiving portion and a second button portion pressing the pressing member,
The first button part,
A pressing part protruding outward through the first through hole of the housing; And
Includes; a plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the receiving part by an external force,
The second button portion is formed extending from the pressing member toward the second plate, and the microstructure shooting device protrudes outward through a second through hole of the upper cover portion and a through hole of the second plate. The method of claim 2,
A first elastic member disposed between the pressing member and the lower cover; And
Microstructure shooting device further comprising a second elastic member disposed between the pressing member and the button portion. The method of claim 1,
When the button portion is pressed to the first depth, the pressing member is pressed so that the microstructure is implanted into the skin,
When pressed to a second depth greater than the first depth, the microstructure shooting device presses the receiving portion so that the liquid drug is discharged to the surface of the skin. The method of claim 7,
The pressing member,
A plate-shaped first plate;
A plurality of pressing protrusions protruding from the first plate toward the lower cover portion and having the microstructure formed at one end; And
Microstructure shooting device comprising; an extension part extending one side of the first plate and the button part. The method of claim 8,
The pressing member,
A stop portion protruding from the lower cover portion toward the first plate and formed to be spaced apart from the first plate by a predetermined distance; And
A locking part provided at one end of the extension part and inserted into the extension part by the support force of the first plate by the stopping part,
A microstructure shooting device in which an interval between the first plate and the button portion is reduced by the insertion of the locking portion. The method of claim 7,
The button part,
A pressing part protruding outward through the first through hole of the housing;
A plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the pressing member by an external force; And
Microstructure shooting device comprising; a protrusion formed protruding from the second plate toward the receiving portion and spaced apart from the receiving portion at a predetermined interval. The method of claim 1,
The button portion includes a first button portion pressing the receiving portion and a second button portion pressing the pressing member,
The first button part,
A pressing part protruding outward through the first through hole of the housing; And
Includes; a plate-shaped second plate formed on one side of the pressing part, disposed in the housing, and pressing the pressing member by an external force,
The second button portion is formed to extend from the receiving portion toward the second plate, the microstructure shooting device protruding outward through the through hole of the second plate. The method of claim 7,
A first elastic member disposed between the pressing member and the lower cover; And
The microstructure shooting device further comprises a second elastic member disposed between the receiving portion and the lower cover portion. The method of claim 1,
Microstructure shooting device further comprising an opening and closing portion provided below the receiving portion to discharge or block the liquid drug to at least one of the plurality of openings as the receiving portion is pressed and moved toward the plurality of openings. The method of claim 1,
The receiving part,
A storage unit receiving the liquid drug and having the outlet formed on the bottom surface thereof; And
And a flow path connecting at least one of the plurality of openings from the outlet,
The storage unit is a microstructure shooting device disposed to be movable through the outlet outside the flow path. The method of claim 14,
A blocking portion formed larger than the width of the outlet; And
Microstructure shooting device further comprising an opening and closing portion including; a support portion extending from the lower side of the blocking portion to the lower cover portion. The method of claim 1,
The plurality of openings are microstructure shooting device including a plurality of first openings through which the microstructures are shot and at least one second opening through which the liquid drug is discharged. The method of claim 16,
The microstructure shooting device in which the lower cover part communicates with the at least one second opening to form at least one flow path having a groove shape having a predetermined depth. The method of claim 16,
The plurality of first openings and the at least one second opening are arranged in an array form, and the at least one second opening is arranged between the plurality of first openings. The method of claim 18,
A microstructure shooting device in which sidewalls are formed along the outer periphery of the lower surface of the lower cover part.

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