KR102211450B1 - Recognize the time of inhalation of the drug inhaler and administer medication - Google Patents

Abstract

The present invention relates to a method of administering a medicament in a medicament inhaler for recognizing an inhalation point, comprising: a position step in which the nozzle of the medicament inhaler is positioned in the direction of the user's respiratory system; Respiration measurement step of sensing inhalation and exhalation after the positioning step; A patterning step of detecting and patterning the exchange cycle of the user's inhalation and exhalation when inhalation and exhalation are repeated three or more times according to the respiration measurement step; After the patterning step, the control unit analyzes the pattern value to predict the inhalation point of the user; And an injection step of injecting a drug contained in the drug storage unit toward the user's respiratory system from a nozzle included in the drug inhaler at the time determined in the adjusting step.

Description

A method of administering a drug in a drug inhaler that recognizes the timing of inhalation {RECOGNIZE THE TIME OF INHALATION OF THE DRUG INHALER AND ADMINISTER MEDICATION}

The present invention relates to a method of administering a medicament in a medicament inhaler that recognizes the time of inhalation. In more detail, the present invention relates to a drug inhaler for recognizing the time of inhalation that can automatically recognize the time of inhalation so that it is easier to administer the drug by itself at the time of inhalation of the patient in the case of respiratory drugs that deliver drugs to the bronchi, and It is to provide a method of administering a drug accordingly.

Quantitative drug inhalers or dry powder inhalers are well known as drug inhalers for treating or alleviating the effects of respiratory diseases such as asthma. Since this is mainly a method of administering and directly delivering a drug to the respiratory tract, it is classified according to the nature of the drug and the principle of injection. However, since the above inhaler is mainly used for asthma disease, it is generally called as an asthma drug inhaler in many cases.

Most of these inhaler devices can be used with pressurized aerosol supply containers. The supply vessel contains a valve and when the inner springs that operate these valves are sufficiently compressed, the valve allows the release of a fixed amount of aerosol.

Typically, such a supply device includes a chamber having a mouthpiece, an air inlet, an operating means for actuating the valve of the supply container, a locking means for releasably fixing the valve in a charged state, and a locking means, which is a latch, to be quantified. It consists of an inhalation response means for discharging the aerosol compound of the mouthpiece to the area of the mouthpiece. All of the objectives are to match the drug release from the aerosol container to the patient's inhalation action so that the maximum dose of the drug can reach the bronchi of the lungs.

Typically, prior art inhalers include a housing in which the aerosol drug container is removably disposed. This container has a nozzle at one end supported by a structure that provides an air passage extending toward the mouthpiece through which the patient is inhaled. In most prior art inhalers, the aerosol container can be separated from the inhaler housing so that effective cleaning of the structures forming the air flow path can be performed. In some inhalers, the housing is configured to allow the user to combine and use the aerosol drug container while still allowing the container to be removed for cleaning.

In using these devices, it is desirable for the user to check whether the container is placed in the inhaler, whether or not the inhaler can supply the drug sufficiently many times for a certain period of time. Along with this information, the user should be able to know when to change the medicine container.

In the prior art, attempts have been made to allow a user to obtain and use information indicating the number of doses, that is, a quantitative drug supplied from a drug inhaler, and information indicating the number of doses remaining in the drug inhaler.

While such a mechanical count/operation assembly can provide dosing operation information to a user, a conventional inhaler developed later provides similar information through an electronic or electromechanical dosing counter and indicator assembly.

In addition, from the user's point of view, the quantitative spray inhaler (MPI), dry powder inhaler (DPI), and mist type inhaler (SMI) differ slightly in the principle of injection from the drugs provided, but in terms of delivery of respiratory drugs to the bronchi. Are common. In addition, the above quantitative spray inhaler (MPI), dry powder inhaler (DPI), and mist type inhaler (SMI) all have a common point that the patient must directly inject the drug at the time of breathing at which his or her inhalation occurs.

Since the drug must be accurately injected at the time of inhalation as described above, in the case of children or elderly patients, it is somewhat difficult to accurately inject the drug, and accordingly, there is a problem that the drug is lost. Accordingly, it is difficult to obtain an effective therapeutic effect, and further, there is a problem that diseases such as oral candidiasis may be caused by drugs remaining in the oral cavity in children or elderly patients with weak inhalation power.

Therefore, while recognizing the above problems, a drug inhaler was developed that recognizes the point of inhalation and accurately injects drugs.

In relation to the prior art, prior art 1 (KR 10-2008-0044343 A) discloses an inhaler provided with a cover that is movable between closed and open positions to cover or not cover the mouthpiece. However, the prior art 1 is only for facilitating quantitative spraying and preventing unintended spraying, and has limitations in solving the above-described problems.

In addition, although prior art 2 (KR 10-2010-0032662 A) provides a portable inhaler, it has a limitation in that it cannot solve the above-described problem.

KR 10-2008-0044343 A KR 10-2010-0032662 A

It is an object of the present invention to provide a method for administering a drug in a drug inhaler that recognizes the user's inhalation and recognizes the timing of inhalation so that an appropriate amount of the drug can be administered or delivered to the bronchi.

It is an object of the present invention to provide a method for administering a drug in a drug inhaler that recognizes the time point of inhalation that can conveniently deliver a respiratory drug and a composition that can be used for the respiratory system in a quantitative manner.

In order to achieve the above object, a method of administering a medicament in a medicament inhaler for recognizing a time point of inhalation according to an embodiment of the present invention comprises: positioning a nozzle of the medicament inhaler in the direction of the user's respiratory system; Respiration measurement step of sensing inhalation and exhalation after the positioning step; A patterning step of detecting and patterning the exchange cycle of the user's inhalation and exhalation when inhalation and exhalation are repeated three or more times according to the respiration measurement step; After the patterning step, the control unit analyzes the pattern value to predict the inhalation point of the user; And an injection step of injecting the drug contained in the drug storage unit toward the user's respiratory system from the nozzle included in the drug inhaler at the time determined in the adjusting step.

In the drug administration method of a drug inhaler for recognizing the time of inhalation, the drug inhaler comprises: a drug storage unit; A nozzle part for injecting a drug; A face cover; And a sensing unit for sensing inhalation and exhalation, and the sensing unit is installed on a face cover unit provided to cover the user's face, and in the respiration measurement step, the sensing unit performs drug administration according to the user's selection. Initiating step of receiving a signal for initiating breathing; A breathing recognition step of recognizing inhalation and exhalation according to the concentration of carbon dioxide through a carbon dioxide sensor included in the sensing unit; And a respiratory classification step of transmitting an inhalation time point and an exhalation time point to the control unit after the respiration recognition step.

In the drug administration method of the drug inhaler for recognizing the time of inhalation, the sensing unit includes a pressure measurement sensor, and the respiration recognition step and the respiration classification step include a pressure value measured by the pressure measurement sensor. It may be determined according to the range.

In the drug administration method of the drug inhaler for recognizing the time of inhalation, the drug storage unit is composed of an auxiliary agent storage unit for respiration stabilization and a main drug storage unit, and the injection step is included in the drug inhaler at a time determined in the adjustment step A first injection step of spraying the breathing stabilizing aid contained in the breathing stabilizing aid storage unit from the nozzle to the user's respirator; An injection evaluation step of evaluating whether or not the drug inhalation step was successfully injected in the first injection step; And a second injection step of injecting the main drug contained in the main drug storage unit toward the user's respirator from the nozzle included in the drug inhaler at the time determined in the adjustment step when the first injection step is successful in the evaluation step. It may be to include.

In the method of administering a drug in a drug inhaler for recognizing the time of inhalation, the main drug may be a drug for improving asthma.

In the method of administering a drug in a drug inhaler for recognizing the time of inhalation, the adjuvant for respiration stabilization may be a plant extract.

In the drug inhaler according to another embodiment of the present invention, a drug administration method of a drug inhaler for recognizing the time of inhalation may be applied.

Hereinafter, the present invention will be described in more detail.

A method of administering a drug in a drug inhaler for recognizing a time point of inhalation according to an embodiment of the present invention includes a position step (S1) in which the nozzle of the drug inhaler is positioned in the direction of the user's respiratory system; Respiration measurement step (S2) of sensing inhalation and exhalation after the positioning step (S1); When the inhalation and exhalation are repeated three or more times according to the respiration measurement step (S2), a patterning step (S3) of detecting and patterning the exchange cycle of the user's inhalation and exhalation (S3); After the patterning step, the control unit analyzes the pattern value to predict the inhalation point of the user (S4); And an injection step (S5) of injecting the drug contained in the drug storage unit 100 toward the user's respiratory system from the nozzle included in the drug inhaler at the time determined in the adjusting step (S4).

The drug inhaler 1000 used in the present invention includes a drug storage unit 100; Nozzle part 200: It may include a face cover part 300 and a sensing part 400.

The medicament storage unit 100 is to store the medicament for delivery to the respiratory tract, and the medicament can be stored in a pressure container, and the medicament is stored in a container other than a pressure container according to the design of a person having ordinary skill in the relevant field. May be. Meanwhile, the drug storage unit 100 may store a single drug, but if necessary, different drugs may be stored in each of a plurality of containers.

The nozzle unit 200 is a nozzle device for injecting drugs in the direction of the user's respiratory tract, and includes all injection methods that can be used by a person of ordinary skill in the relevant field.

The face cover part 300 covers a certain area of the user's face so that carbon dioxide generated from the user's breathing is easily collected between the inside of the face cover part and the user's face, and pressure changes of exhalation and inhalation are It is used to make it possible to measure. Therefore, it includes all of the face cover that can be used for the above purpose by those of ordinary skill in the relevant field, and the material and shape are not particularly limited under the above-described purpose.

The sensing unit 400 includes a carbon dioxide measuring sensor capable of measuring a change in the amount of carbon dioxide generated during the breathing process of the user; It may include a pressure sensor capable of measuring the pressure change inside the face cover. The type of the sensor is not particularly limited, and may include all types of sensors that can be used by those of ordinary skill in the relevant field for the purpose.

Referring to FIGS. 1 and 2, a drug inhaler 100 including the drug storage unit 100, the nozzle unit 200, the face cover unit 300, and the sensing unit 400 can be confirmed. However, this is exemplary, and is not limited to the shape shown in the drawings. When explaining the coupling relationship between the drug storage unit 100, the nozzle unit 200, the face cover unit 300 and the sensing unit 400 together with the drawing, the drug storage unit 100 and the nozzle unit 200 The face cover part 300 may be fitted to the combined drug inhaler. Accordingly, the nozzle part 200 allows the medicine contained in the medicine storage part 100 to be sprayed and provided through the mouth of the user.

Meanwhile, referring to FIGS. 1 and 2, it is an example in which the sensing unit 400 is installed to measure carbon dioxide and pressure changes generated while the user breathes through the mouth.

On the other hand, referring to FIGS. 3 and 4, it is shown to measure the pressure change of carbon dioxide that occurs while the user breathes through the nose.

When the drug inhaler of the present invention is installed as shown in FIGS. 3 and 4 unlike FIGS. 1 and 2, the measured pattern of inhalation and exhalation because the user must breathe with the mouth at the time the drug is provided while breathing through the nose This may vary and may be inappropriate. Therefore, as shown in FIGS. 1 and 2, the sensing unit 400 is preferably disposed to measure the breathing of the user through the mouth.

In addition, the sensing unit 200 may be installed on the face cover unit 300.

The positioning step (S1) means that the user brings the drug inhaler 1000 closer to the face in order to inhale the drug, and the range includes all ranges that can be arbitrarily determined by a person having ordinary knowledge in the field. Can be. In addition, the range is determined by measuring the distance between the face and the face cover part 300 through a distance measuring sensor installed in the face cover part 300, and the location step (S1) is performed when the measured value falls within a predetermined range. It can be recognized as progressing.

The respiration measurement step (S2) is a step of recognizing the user's breath through a sensor included in the sensor unit 400 and recognizing the inhalation and exhalation of the breath.

The patterning step (S3) analyzes the pressure value and carbon dioxide value checked through the sensor to determine the peak at the time of inhalation and the peak at the time of exhalation of the user, and are used for the peak at the time of inhalation and the peak at the time of exhalation. It may be to analyze time to determine patterns of inhalation and exhalation.

The adjusting step (S4) refers to predicting the next inhalation time point based on the patterns of inhalation and exhalation measured in the patterning step (S4).

The injection step (S5) is to spray the drug stored in the drug storage unit 100 through the nozzle unit 200 in the direction of the user's respiratory tract at the time predicted in the adjusting step (S4).

In the drug administration method of a drug inhaler for recognizing the time of inhalation, the drug inhaler comprises: a drug storage unit 100; Nozzle part 200 for injecting a drug; A face cover part 300; And a sensing unit 400 for sensing inhalation and exhalation, and the sensing unit 400 is installed on a face cover unit 300 provided to cover the user's face, and the respiration measurement step (S2) The sensing unit 400 is an initiation step (S2.1) of receiving a signal initiating breathing for drug administration according to the user's selection; Breathing recognition step (S2.2) of recognizing inhalation and exhalation according to the concentration of carbon dioxide through a carbon dioxide sensor included in the sensing unit 400; And a respiration classification step (S2.3) of transmitting the inhalation time point and the exhalation time point to the control unit after the respiration recognition step (S2.2).

In the drug administration method of the drug inhaler for recognizing the time of inhalation, the sensing unit 400 includes a pressure measurement sensor, and the respiration recognition step (S2.2) and the respiration classification step (S2.3) include the It may be determined according to a predetermined range including the pressure value measured by the pressure measurement sensor.

The initiation step (S2.1) is to receive an input from the user and receive a signal for starting breathing. The method of receiving input from the user is assumed to include all methods that can be determined by a person having ordinary knowledge in the relevant field. For example, when three large exhalations are repeated, the initiation step may be performed. Through this, it is possible to prevent initiation due to malfunction in the respiration measurement step (S2).

The breathing recognition step (S2.2) and the breathing classification step (S2.3) may be to detect a change in the amount of carbon dioxide, and preferably, the pressure change value measured by the pressure sensor is used as a first element, and the carbon dioxide sensor The measured value may be used as the second element, the peak values of inhalation and exhalation are determined based on the peak of the pressure value through the first element, and the measured peak value is verified through the second element.

This is because the value measured through the pressure sensor can be more accurate in measuring the peak and period of inhalation and exhalation. In particular, in the case of the carbon dioxide sensor, since the amount of carbon dioxide remaining inside the face cover part 300 is accumulated, an error becomes large when the cycle is derived based on the second factor. Therefore, it is possible to increase the accuracy of recognizing inhalation and exhalation by determining the cycle of inhalation and exhalation through the first factor, and by analyzing the cumulative cycle of accumulated carbon dioxide and verifying the period of inhalation and exhalation determined according to the first factor. .

In the drug administration method of the drug inhaler for recognizing the time of inhalation, the drug storage unit 100 is composed of an auxiliary agent storage unit for respiration stabilization and a main drug storage unit, and the injection step (S5) includes the control step (S4). A first injection step (S5.1) of injecting the breathing stabilizing adjuvant contained in the breathing stabilizing adjuvant storage unit toward the user's respiratory system from the nozzle included in the drug inhaler at the time determined in ); An injection evaluation step (S5.2) of evaluating whether or not the drug inhalation step was successfully injected in the first injection step (S5.1); And if the first injection step (S5.1) is successful in the evaluation step, the main drug contained in the main drug storage unit is transferred from the nozzle included in the drug inhaler to the user's respirator at the time determined in the adjustment step (S4). It may be to include; a second injection step (S5.3) of spraying toward.

The adjuvant for respiration stabilization referred to in the present invention refers to a composition that instantly expands the airways based on plant extracts so that breathing can occur evenly. In the case of using the breathing stabilizing aid, the cycle of inhalation and exhalation is accurate, and the inhalation is more stabilized, so that the user can maintain a good breathing state in which the main drug is inhaled.

In particular, this can be advantageous for inhalation of the main drug through inhalation because it can stabilize the inhalation momentarily for an elderly patient.

On the other hand, the adjuvant for respiration stabilization should not have side effects on itself and should not have an effect on the main drug, so it should be a plant extract and have a fast vaporization.

In the case of the first propellant step (S5.1), inhalation and exhalation of the user may be recognized, and if the patterned measurement and analysis values are incorrect, it may be corrected. That is, in general, in the case of children or elderly patients, when the main drug is inhaled due to an incorrect inhalation cycle, there is a problem that it is impossible to know how much insufficient amount is provided as the drug is only partially provided compared to the amount by the respiratory tract. Accordingly, an insufficient amount is inhaled again by the patient's sense, and there is a problem in that the amount is insufficient or an excessive amount of drugs is provided to the patient during this process.

However, in the case of the first propellant step (S5.1), unlike the main agent, the breathing stabilizing aid does not have to be accurately delivered in quantity, so there is no such problem even if the breathing pattern is incorrectly measured. In addition, it has the advantage of being able to correct incorrectly measured breathing patterns. Furthermore, since the breathing stabilizing adjuvant itself can more stabilize the user's breathing, especially inhalation, it has the advantage of allowing the user to be in a more advantageous state for inhaling the drug to the user through inhalation.

In the method of administering a drug in a drug inhaler for recognizing the time of inhalation, the main drug may be a drug for improving asthma.

The main agent refers to an asthma treatment for inhalation, and includes all those that can be used as a spray-type inhalant for asthma that can be used by those with ordinary knowledge in the field, such as steroids and anticholinergic agents. The main drug is to be provided in a fixed amount periodically, and the second injection step (S5.3) is performed after the injection evaluation step (S5.2) is performed after the first injection step (S5.1). In accordance with the user's inhalation cycle, the main drug can be inhaled into the user's bronchi without loss in a quantitative amount.

In the method of administering a drug in a drug inhaler for recognizing the time of inhalation, the adjuvant for respiration stabilization may be a plant extract.

Preferably, the respiratory stabilizing adjuvant comprises applemint extract; Based on 100 parts by weight of the applemint extract, 10 to 30 parts by weight of rosemary extract; 10 to 30 parts by weight of laurel extract; 1 to 5 parts by weight of lettuce extract; 1 to 5 parts by weight of potato peel extract; And 0.1 to 1 part by weight of lime extract.

In the case of the above range, the user's airway may be instantly expanded and inhalation may be stabilized. In particular, in the case of a supplement using a general herb, it may be advantageous for airway expansion, but there is a problem in that the pattern of inhalation and exhalation is collapsed in many cases where the user coughs due to airway stimulation.

However, in the case of the above range, since there is no airway irritation to the user, coughing does not occur, a breathing state that is good for inhaling the main drug may be obtained with more instantaneous stable breathing.

In addition, in the case of respiratory diseases, since the drug must be inhaled periodically at regular intervals for a long period of time, the palatability of the above supplements is very important. In the case of the above range, it has the advantage of being able to conveniently provide a wider range of patients with high palatability.

In the drug inhaler according to another embodiment of the present invention, a drug administration method of a drug inhaler for recognizing the time of inhalation may be applied.

The drug administration method of a drug inhaler for recognizing the time of inhalation according to the present invention enables the administration or delivery of an appropriate amount of the drug to the bronchi by recognizing the user's inhalation.

The method of administering a drug in a drug inhaler for recognizing the time of inhalation according to the present invention makes it possible to conveniently deliver a respiratory drug and a composition that can be used for other respiratory systems in a quantitative manner.

1 illustrates a drug inhaler for recognizing an inhalation point according to an embodiment of the present invention.
2 is a diagram illustrating a drug inhaler for recognizing an inhalation point according to an embodiment of the present invention.
3 illustrates a case in which a sensing unit is disposed at a different position in order to compare with a drug inhaler that recognizes an inhalation point according to an embodiment of the present invention.
4 illustrates a case in which a sensing unit is disposed at a different position in order to compare with a drug inhaler for recognizing an inhalation point according to an embodiment of the present invention.
5 is a flowchart illustrating a method of administering a drug by a drug inhaler for recognizing an inhalation time point according to an embodiment of the present invention.
6 is a flowchart illustrating a method of administering a drug by a drug inhaler for recognizing an inhalation time point according to an embodiment of the present invention.
7 is a flow chart illustrating a method of administering a drug by a drug inhaler for recognizing an inhalation time point according to an exemplary embodiment of the present invention.
8 is a flowchart illustrating a method of administering a drug by a drug inhaler for recognizing an inhalation time point according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Production Example: Preparation of a breath stabilization aid]

In the present invention, an aid for stabilizing breathing for use in the first injection step was prepared according to the composition shown in [Table 1] below. Each extract was prepared by the hot water extraction method and mixed in the same composition as in [Table 1] below.

(A: applemint extract, B: rosemary extract, C: laurel extract, D: lettuce extract, E: potato peel extract, F: lime extract, G: mint extract.)

M1 M2 M3 M4 M5 M6 M7 M8 M9 A - 100 100 100 100 100 100 100 100 B - - 5 10 20 30 40 20 - C - - 5 10 20 30 40 20 - D - - 0.5 One 3 5 7 - 5 E - - 0.5 One 3 5 7 - 5 F - - 0.05 0.1 0.5 One 1.5 - - G 100 - - - - - - - -

(Unit: parts by weight)

[Experimental Example: Example Evaluation]

For 20 adults, the compositions according to M1 to M9 were vaporized, respectively, and injected into a respirator to inhale. Thereafter, the degree of stabilization of inhalation was evaluated by a 10-point scale method compared with M1 to be expressed as an index of 1 to 10. (TU) The higher the number, the better the effect. In addition, the degree of coughing was compared in the same way. (TX) Again, the higher the number, the better the effect. In addition, the tester was asked to evaluate palatability according to a 10-point scale compared to M1 for subjects with a TX value of 5 or more. (TY) Similarly, the higher the number, the better the effect.

The results are shown in the following [Table 2].

M1 M2 M3 M4 M5 M6 M7 M8 M9 TU 5 2 3 7 8 7 5 3 3 TX 5 4 4 6 7 7 3 3 6 TY 5 - - 5 7 7 5 - 4

(Unit: index)

Referring to the above range, it can be seen that in the case of M4 to M6 temporarily stabilizes inhalation without stimulating the airways. It was also confirmed that palatability was also excellent.

Therefore, in the case of the above range, it can be used as an aid for stabilizing breathing to temporarily stabilize inhalation without stimulating the airways. In addition, since it has excellent palatability, it has the advantage of easy dissemination.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

1000: drug inhaler that recognizes the point of inhalation
100: drug storage unit
200: nozzle part
300: face cover part
400: sensing unit

Claims (7)

A drug storage unit consisting of an auxiliary agent storage unit for respiration stabilization and a main drug storage unit;
A nozzle part for injecting a drug;
A face cover; And
It is installed on the face cover and includes a pressure measurement sensor, and includes a sensing unit for sensing inhalation and exhalation,
Positioning step in which the nozzle of the drug inhaler is located in the direction of the user's respiratory system; Respiration measurement step of sensing inhalation and exhalation after the positioning step; A patterning step of detecting and patterning the exchange cycle of the user's inhalation and exhalation when inhalation and exhalation are repeated three or more times according to the respiration measurement step; After the patterning step, the control unit analyzes the pattern value to predict the inhalation point of the user; And an injection step of injecting a drug contained in the drug storage unit toward the user's respiratory tract from a nozzle included in the drug inhaler at the time determined in the adjusting step;
The respiration measurement step, the sensing unit initiation step of receiving a signal for starting respiration for drug administration according to the user's selection; Breathing recognition step of recognizing inhalation and exhalation according to the concentration of carbon dioxide through a carbon dioxide sensor included in the sensing unit; And a breathing classification step of transmitting an inhalation time point and an exhalation time point to a control unit after the breathing recognition step,
The spraying step includes: a first spraying step of injecting the breathing stabilizing aid contained in the breathing stabilizing aid storage unit toward the user's respirator from the nozzle included in the drug inhaler at the time determined in the adjusting step; An injection evaluation step of evaluating whether or not the drug inhalation step was successfully injected in the first injection step; And a second injection step of injecting the main drug contained in the main drug storage unit toward the user's respirator from the nozzle included in the drug inhaler at a time determined in the adjustment step when the first injection step is successful in the evaluation step. Including,
The breathing recognition step; The respiratory classification step and the evaluation step are determined by the controller according to a predetermined range based on information including the pressure value measured by the pressure measurement sensor.
Medicine inhaler. delete delete delete The method of claim 1,
The main drug is a drug for improving asthma
Medicine inhaler. The method of claim 1,
The respiratory stabilization adjuvant is a plant extract
Medicine inhaler. delete

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