KR102209585B1 - System and method for measuring three-dimensional dose distribution - Google Patents

Abstract

A system and method for measuring a three-dimensional dose distribution are provided. The three-dimensional dose distribution measurement system includes a fluorescent plate disposed in the center, a phantom module receiving radiation provided from a linear accelerator, and rotating the phantom while supporting the phantom by being installed under the phantom module, and irradiation of the linear accelerator A rotating body rotating in a direction perpendicular to a direction and a plurality of cameras irradiating radiation to the phantom module from the linear accelerator, and obtaining converted light through the fluorescent plate of the phantom module when the rotating body rotates do.

Description

3D dose distribution measurement system and method {SYSTEM AND METHOD FOR MEASURING THREE-DIMENSIONAL DOSE DISTRIBUTION}

The present invention relates to a system and method for measuring a three-dimensional dose distribution.

In recent years, complex and high-dose treatments are increasing, and the importance of accurate dose verification and patient quality control is increasing.

Particularly, in the case of the latest particle radiation therapy, as a treatment method using the characteristics of a beam capable of adjusting a three-dimensional dose distribution using a range modulation, it is essential to verify a three-dimensional dose distribution before treatment.

As a method of measuring the conventional dose distribution, one-dimensional point dose measurement using a chamber, Optically Stimulated Luminescence Dosimeters (OSLD), and Thermal Fluorescence Dosimeter (TLD), etc. ), 2D measurement by diode array including Gafchromic film and electronic portal imaging device (EPID), 3D measurement using gel dosimetry, etc. There is this.

In the case of one-dimensional point dose measurement using a chamber, Optically Stimulated Luminescence Dosimeters (OSLD), and Thermal Fluorescence Dosimeter (TLD), the absolute dose can be analyzed. However, it has the advantage of being accurate and simple, but it has the disadvantage that it is impossible to confirm the most important dose distribution, and the reliability is poor in areas with large dose changes.

In the case of a two-dimensional measurement by a diode array including a Gafchromic film and an electronic portal imaging device (EPID), there is an advantage that it is possible to obtain a two-dimensional dose distribution. , There are two-dimensional limitations, real-time dose analysis is difficult, and the film has disadvantages of inferior economics.

In the case of three-dimensional measurement using gel dosimetry, there is an advantage in that it is possible to obtain a three-dimensional dose distribution, but the overall process including gel production is difficult and post-processing is necessary, so real-time analysis is limited. There is a disadvantage in that economical efficiency and reproducibility are poor.

Korean Registered Patent Publication No. 10-1739915, 2017.05.19.

The problem to be solved by the present invention is to obtain a 3D dose distribution in real time for patient quality control.

In addition, the problem to be solved by the present invention is to measure an accurate dose distribution in the measurement of a three-dimensional dose distribution in a medium.

The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems that are not mentioned will be clearly understood by those skilled in the art from the following description.

A three-dimensional dose distribution measuring system according to an embodiment of the present invention for solving the above-described problems includes a phantom module having a fluorescent plate disposed in the center, receiving radiation provided from a linear accelerator, and being installed under the phantom module to support the phantom. The phantom is rotated in a state, wherein radiation is irradiated to the phantom module from a rotating body rotating in a direction perpendicular to a radiation irradiation direction of the linear accelerator and the linear accelerator, and when the rotating body rotates, the It includes a plurality of cameras for acquiring the light converted through the fluorescent plate.

The phantom module has a cylindrical shape and is made of transparent acrylic.

The phantom module includes two semi-cylindrical acrylic phantoms of the same size and a fluorescent plate, and the two acrylic phantoms are combined to form a cylindrical shape, but each fluorescent plate is disposed on the flat portions of the two acrylic phantoms. In the fluorescent plate, a portion including a phosphor is disposed in a direction toward a circular portion of the semi-cylindrical acrylic phantom.

In the semi-cylindrical acrylic phantom of the phantom module, a groove for arranging the fluorescent plate is provided, and the groove includes optical grease.

The rotating body includes rotating in the same axis as the irradiation direction of radiation due to a position change of the linear accelerator when the linear accelerator is rotatable.

The plurality of cameras are arranged at intervals of a predetermined angle.

The three-dimensional dose distribution measurement system according to an embodiment of the present invention for solving the above-described problem further includes an image processing unit for processing a plurality of images acquired through the plurality of cameras to reconstruct a three-dimensional image, the The image processing unit corrects the distortion of the camera with respect to the plurality of acquired images, removes the scattering component from the plurality of images, and includes a plurality of images photographed at each rotation angle from the plurality of cameras and the acquired It reconstructs a three-dimensional image by using the rotation angle of a plurality of images.

The three-dimensional dose distribution measurement system according to an embodiment of the present invention for solving the above-described problem further includes an analysis unit for analyzing a three-dimensional dose distribution using the reconstructed three-dimensional image, and the analysis unit includes: A three-dimensional dose distribution is represented using a look-up table representing a pixel value of a reconstructed three-dimensional image as a dose value, a measured three-dimensional dose distribution represented by the measured plurality of images, and a patient treatment system (treatment planning system). ) To compare and analyze the calculated 3D dose distribution calculated through), and the lookup table is shown by assigning dose values to pixel values using 3D images for a plurality of doses.

In the method for measuring a three-dimensional dose distribution according to an embodiment of the present invention for solving the above-described problem, a computer obtains a plurality of images, wherein the plurality of images include radiation emitted from a linear accelerator from a fluorescent plate of a phantom module. Acquiring a plurality of images, which are acquired by a plurality of cameras by the emitted light, the step of correcting the distortion of the camera for the plurality of images obtained by the computer, the computer with respect to the plurality of images Removing the scattering component, and reconstructing, by the computer, a three-dimensional image using a plurality of images taken at each rotation angle from the plurality of cameras and the rotation angle of the obtained plurality of images. .

A method for measuring a three-dimensional dose distribution according to an embodiment of the present invention for solving the above-described problem is a three-dimensional dose using a lookup table in which the computer converts the pixel value of the reconstructed three-dimensional image into a dose value. Displaying the distribution and comparing and analyzing the measured 3D dose distribution displayed using the plurality of images measured by the computer and the calculated 3D dose distribution calculated through the patient treatment system (treatment planning system). Including, the lookup table is shown by allocating a dose value relative to a pixel value using a 3D image for a plurality of doses.

The three-dimensional dose distribution measuring computer program according to an embodiment of the present invention for solving the above-described problems is combined with a computer that is hardware, and is stored in a medium to execute any one of the above-described methods.

Other specific details of the present invention are included in the detailed description and drawings.

According to the present invention, it is possible to measure a three-dimensional dose distribution using a two-dimensional image, and obtain a three-dimensional dose distribution and manage patient quality in real time.

In addition, according to the present invention, since it can be used continuously due to one system construction, cost can be reduced.

Further, according to the present invention, it is possible to accurately measure the dose distribution, and the reproducibility of the dose distribution can be improved.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a diagram showing the entire 3D dose distribution measurement system according to an embodiment of the present invention.
2 is an exploded view of the phantom module of the present invention.
3 and 4 are diagrams showing experimental results that vary depending on whether optical grease is included in the groove of the phantom module of the present invention.
5 is a diagram illustrating a method of measuring a three-dimensional dose distribution according to an embodiment of the present invention.
6 is a diagram illustrating a method of measuring a 3D dose distribution by comparing and analyzing the 3D dose distribution according to the present invention.

Advantages and features of the present invention, and a method of achieving them will become apparent with reference to the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in a variety of different forms, only the present embodiments are intended to complete the disclosure of the present invention, It is provided to fully inform the technician of the scope of the present invention, and the present invention is only defined by the scope of the claims.

The terms used in the present specification are for describing exemplary embodiments and are not intended to limit the present invention. In this specification, the singular form also includes the plural form unless specifically stated in the phrase. As used in the specification, “comprises” and/or “comprising” do not exclude the presence or addition of one or more other elements other than the mentioned elements. Throughout the specification, the same reference numerals refer to the same elements, and “and/or” includes each and all combinations of one or more of the mentioned elements. Although "first", "second", and the like are used to describe various elements, it goes without saying that these elements are not limited by these terms. These terms are only used to distinguish one component from another component. Therefore, it goes without saying that the first component mentioned below may be the second component within the technical idea of the present invention.

Unless otherwise defined, all terms (including technical and scientific terms) used in the present specification may be used as meanings that can be commonly understood by those of ordinary skill in the art to which the present invention belongs. In addition, terms defined in a commonly used dictionary are not interpreted ideally or excessively unless explicitly defined specifically.

Spatially relative terms "below", "beneath", "lower", "above", "upper", etc., as shown in the figure It can be used to easily describe the correlation between a component and other components. Spatially relative terms should be understood as terms including different directions of components during use or operation in addition to the directions shown in the drawings. For example, if a component shown in a drawing is turned over, a component described as "below" or "beneath" of another component will be placed "above" the other component. I can. Accordingly, the exemplary term “below” may include both directions below and above. Components may be oriented in other directions, and thus spatially relative terms may be interpreted according to orientation.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a diagram showing the entire 3D dose distribution measurement system according to an embodiment of the present invention.

Referring to FIG. 1, a 3D dose distribution measuring system according to an embodiment of the present invention includes a phantom module 10, a rotating body 20, and a plurality of cameras 30-1 and 30-2.

A fluorescent plate is disposed in the center of the phantom module 10, and the phantom module 10 receives radiation provided from various treatment equipment including a linear accelerator 40 and a particle radiation treatment device.

In addition, the phantom module 10 has a cylindrical shape and is made of transparent acrylic.

The specific configuration of the phantom module 10 will be described in detail in FIG. 2.

The rotating body 20 is installed under the phantom module 10 to rotate the phantom module 10 while supporting the phantom module 10, in a direction perpendicular to the radiation irradiation direction of the linear accelerator 40 Rotate.

In one embodiment, the radiation irradiation direction of the linear accelerator 40 is the y-axis direction, and the rotation direction of the rotating body 20 is the x-axis direction.

The rotating body 20 is composed of a rotation speed, weight and size that can stably rotate while rotating the phantom module 10 at a predetermined speed based on the weight and size of the phantom module 10 .

The rotating body 20 is preferably composed of a rotational speed, weight, and size capable of stably rotating a weight of about 4kg at a speed of about 1000rpm (17rps).

In addition, when the linear accelerator 40 is rotatable, the rotating body 20 includes rotating in the same axis as the irradiation direction of radiation due to a change in the position of the linear accelerator.

That is, in one embodiment, when the radiation irradiation direction of the linear accelerator 40 is basically the y-axis direction, and the rotation direction of the rotating body 20 is the x-axis direction, the linear accelerator 40 is rotatable, and x Even when the radiation irradiation direction is changed to the axis, the rotation direction of the rotation body 20 remains the x-axis direction, and the rotation body 20 can rotate in the same direction as the radiation irradiation direction of the linear accelerator 40.

The plurality of cameras 30-1 and 30-2 are irradiated with radiation from the linear accelerator 40 to the phantom module 10, and are converted through the fluorescent plate of the phantom module 10 when the rotating body 20 rotates. It is to acquire light.

At least two cameras 30-1 and 30-2 should be arranged. When photographing a rotating object, when photographing with one camera, the resulting image is not clear at the corners.

Therefore, by arranging two or more cameras and photographing them at the same time, insufficient information in the blurred portion can be compensated for each other, thereby minimizing the blurring effect occurring in the corner portion of the image obtained by the camera.

The plurality of cameras 30-1 and 30-2 may include all general cameras, and preferably may be CCD (Charge-Coupled Device) cameras, and images can be acquired even with fast rotation, and a small amount Any camera that is highly responsive to photons of can be included.

Arrangement positions of the plurality of cameras 30-1 and 30-2 may be arranged at predetermined angles and intervals, and preferably, the plurality of cameras 30-1 and 30-2 are arranged at intervals of 90 degrees. .

In addition, the plurality of cameras 30-1 and 30-2 are disposed at a position where the primary radiation is not directly incident on the sensor of the camera, and the plurality of cameras 30-1 and 30-2 are simultaneously Is to shoot.

In FIG. 1, two cameras 30-1 and 30-2 are created, but the cameras 30-1 and 30-2 include all two or more cameras.

2 is an exploded view of the phantom module of the present invention.

Referring to FIG. 2, the phantom module 10 of the present invention includes phantoms 11-1 and 11-2 and fluorescent plates 12-1 and 12-2.

The phantoms 11-1 and 11-2 are semi-cylindrical shapes of the same size, and when combined, form a cylindrical shape.

That is, the phantom module 10 is configured in a cylindrical shape by combining two phantoms 11-1 and 11-2 having the same size as a semi-cylindrical shape.

The phantoms 11-1 and 11-2 are made of transparent acrylic.

Fluorescent plates 12-1 and 12-2 are attached to each of the two planar portions of the semi-cylindrical phantoms 11-1 and 11-2.

Fluorescent plates 12-1 and 12-2 are used for detection or observation of radiation, and phosphors that activate zinc and cadmium sulfides in a trace amount of silver, and phosphors that activate zinc sulfide that emits blue light with silver are glass or plastic. It may include thin coatings on a plate, and thin coatings of calcium tungstate and infrared phosphors on a glass or plastic plate.

The direction in which the fluorescent plates 12-1 and 12-2 are disposed on the flat portions of the semi-cylindrical phantoms 11-1 and 11-2 is the direction in which the phosphors of the fluorescent plates 12-1 and 12-2 are applied. These phantoms 11-1 and 11-2 are arranged to face the circular portions, respectively.

That is, when the phantom module 10 is configured, both of the fluorescent plates 12-1 and 12-2 are configured such that the phosphor faces outward.

When the fluorescent plates 12-1 and 12-2 are arranged so that the direction in which the phosphor is applied is toward the circular portion of the phantoms 11-1 and 11-2, the phantoms 11-1 and 11-2 The plurality of cameras 30-1 and 30-2 may acquire light reflected from the phosphor inside.

On the other hand, it is necessary to perform angle correction for lens distortion correction and 3D image configuration of the plurality of cameras 30-1 and 30-2 to be described later.

Therefore, in the phantom module 10, instead of the fluorescent plates 12-1 and 12-2, a grid plate in which a regular pattern is repeated may be disposed to obtain an image whose distortion is corrected.

By arranging a grid plate instead of the fluorescent plates 12-1 and 12-2 to obtain an image, camera distortion information can be analyzed and corrected.

The semi-cylindrical phantoms 11-1 and 11-2 of the phantom module 10 are provided with grooves for arranging the fluorescent plates 12-1 and 12-2, and optical grease is applied to the grooves. Include.

When the groove does not contain optical grease, since total reflection occurs due to an air layer existing in the space between the fluorescent plate corresponding to the groove and the acrylic, an image cannot be obtained at a certain angle or more.

Therefore, by including the optical grease in the groove, there is an effect that an image can be obtained even at a maximum angle.

3 and 4 are diagrams showing experimental results that vary depending on whether optical grease is included in the groove of the phantom module of the present invention.

3(a) is a phantom module 10 containing optical grease, and FIGS. 3(b) to 3(f) are images taken by obtaining light converted from radiation by increasing the angle to be.

Figure 4 (a) is a phantom module 10 that does not contain optical grease, and Figures 4 (b) to 4 (d) are photographed by obtaining light converted from radiation by increasing the angle It is an image.

In FIG. 3A, the fluorescent plate can be observed, and in FIG. 4A, it can be seen that the fluorescent plate cannot be observed due to total reflection.

In addition, FIG. 3(b) to FIG. 3(f) are images taken while varying the angle from 30 degrees to 75 degrees, and a certain amount of the fluorescent plate could be confirmed even at an angle of 75 degrees.

However, FIGS. 4(b) to 4(c) are images taken while varying the angle from 30 degrees to 60 degrees, and as the angle goes from 30 degrees to 60 degrees, the area where the fluorescent plate can be confirmed gradually increases due to total reflection. Decreased.

Therefore, the optical grease serves to prevent total reflection occurring inside the acrylic phantom 10, to derive a clearer image, and to derive an image from any angle.

The 3D dose distribution measuring system according to an embodiment of the present invention further includes an image processing unit.

The image processing unit processes a plurality of images acquired through the plurality of cameras 30-1 and 30-2 to reconstruct a 3D image.

The image processing unit corrects the distortion of the camera with respect to the plurality of acquired images, removes the scattering component from the plurality of images, and applies to a plurality of images captured at each rotation angle from the plurality of cameras and a plurality of acquired images. Reconstructed into a 3D image using the rotation angle of

The distortion of the camera is caused by the lens and is caused by different refractive indices of the center and the outer angle of the lens, and the image processing unit corrects the distortion of the camera with respect to a plurality of images.

The method of correcting the distortion includes lens correction and image correction, but in the present invention, the acquired image itself is corrected.

A method of correcting the distortion of the camera in the acquired image is to calibrate and correct the image based on a normal undistorted image.

As described above, the image additionally obtained by including the grid plate in the phantom module 10 instead of the fluorescent plate is an image whose distortion is corrected, and compared with the image obtained by including the fluorescent plate in the phantom module 10, a fluorescent plate is used. The distortion caused by this can be corrected.

To remove the scattering component for a plurality of images, the scattering component is removed by applying deconvolution.

In removing the scattering component, deconvolution is applied by applying deconvolution using an optical scatter kernel (OSK) or deconvolving using a point spread function (PSF). It may include applying a solution. In addition, in removing the scattering component, various methods of applying deconvolution may be included.

Applying deconvolution using the optical dispersion kernel is to use the optical dispersion kernel based on the measured image array.

The measured image arrangement is the sum of the primary dose component and the optical scattering component, and optical scattering is the convolution of the primary dose component and the light scattering kernel.

To reconstruct a 3D image using the rotation angle, the rotation angle of the rotating body 20 is accurately measured and reconstructed into a 3D image.

In this case, it may further include a digital angle measuring device for accurately measuring the rotation angle.

In computerized tomography (CT), a plurality of cameras 30-1 for each rotation angle of the rotating body 20 are used by using the same method as reconstruction in three dimensions by a plurality of projection images. , 30-2) and reconstructed into a three-dimensional image using a plurality of images captured at the same time.

The reconstruction algorithm for generating a 3D image using the rotation angle may be included regardless of the type, but preferably includes the FDK algorithm.

The three-dimensional dose distribution measurement system according to an embodiment of the present invention further includes an analysis unit.

The analysis unit analyzes a three-dimensional dose distribution using the reconstructed three-dimensional image.

In addition, the analysis unit displays a three-dimensional dose distribution using a look-up table that converts the pixel values of the reconstructed three-dimensional image into a dose value, and a measured three-dimensional dose distribution displayed using the measured plurality of images, and the patient The three-dimensional dose distribution calculated through the treatment planning system is compared and analyzed.

The patient treatment system (treatment planning system) collects various information on the patient and establishes the optimal treatment plan for the patient through a specialized system for drugs, prescription doses, and limiting doses in treatment decisions.

Patient treatment system (treatment planning system), Eclipse ^TM , RayStation, Pinnacle, etc. can be included all regardless of type.

The lookup table is shown by assigning a dose value to a pixel value by using a 3D image for a plurality of doses. The remaining doses that could not be measured other than a plurality of measured doses are calculated through interpolation to construct a lookup table.

By using a lookup table that has already been made through experiments, it is possible to represent a 3D dose distribution based on a reconstructed 3D image.

To compare and analyze the measured 3D dose distribution and the calculated 3D dose distribution, by comparing the 3D dose distribution calculated with the already verified software, how accurate the measured 3D dose distribution value is and whether it can be used clinically. I can judge.

In an embodiment, by comparing the gamma index values, the measurement 3D dose distribution may be analyzed.

By comparing the measured 3D dose distribution and the calculated 3D dose distribution, if the two values match more than a predetermined range, it can be determined that it is clinically usable.

For example, if the predetermined range is 95% or more, the measured 3D dose distribution and the calculated 3D dose distribution are compared, and if 95% or more match, it is determined that it is clinically usable.

The predetermined range may be set by the system user of the present invention, or may be set by the system manufacturer of the present invention.

In the three-dimensional dose distribution measuring system of the present invention, by irradiating radiation to the phantom module 10 including the fluorescent plates 12-1 and 12-2 rotated by the rotating body 20, a plurality of A plurality of images acquired by the cameras 30-1 and 30-2 are reconstructed into a 3D image based on camera distortion correction, scattering component removal, and rotation angle, and the reconstructed 3D image is used using a lookup table. Then, it can be reconstructed into a 3D dose distribution and compared with the calculated 3D dose distribution to determine whether it is clinically usable.

Through the system of the present invention, quality control of the patient is possible in real time, and since it can be used continuously with one system construction, it is economical in terms of cost, and reproducibility is also excellent.

5 is a diagram illustrating a method of measuring a three-dimensional dose distribution according to an embodiment of the present invention.

Referring to FIG. 5, a method for measuring a three-dimensional dose distribution according to an embodiment of the present invention includes the step of obtaining a plurality of images by a computer (S110), and correcting distortion of a camera for a plurality of images obtained by the computer. Step S130, the step of removing the scattering component from the plurality of images by the computer (S150), and the step of reconstructing the plurality of images obtained by the computer into a three-dimensional image using a rotation angle (S170).

In the step S110 of obtaining a plurality of images by the computer, the plurality of images are obtained by using a plurality of cameras by light emitted from the fluorescent plate of the phantom module of radiation emitted from the linear accelerator.

In the step of correcting the distortion of the camera for a plurality of images obtained by a computer (S130), the distortion of the camera is caused by a lens, and is caused by different refractive indices of the center and the outer angle of the lens. Correct the distortion of

The method of correcting the distortion includes lens correction and image correction, but in the present invention, the acquired image itself is corrected.

A method of correcting the distortion of the camera in the acquired image is to calibrate and correct the image based on a normal undistorted image.

As described above, the image additionally obtained by including the grid plate in the phantom module instead of the fluorescent plate is an image whose distortion has been corrected, and the distortion caused by using the fluorescent plate is compared with the image obtained by including the fluorescent plate in the phantom module. Can be corrected.

In step S150 of removing the scattering component from the plurality of images by the computer, removing the scattering component from the plurality of images is to remove the scattering component by applying deconvolution.

In removing the scattering component, deconvolution is applied by applying deconvolution using an optical scatter kernel (OSK) or deconvolving using a point spread function (PSF). It may include applying a solution. In addition, in removing the scattering component, various methods of applying deconvolution may be included.

Applying deconvolution using the optical dispersion kernel is to use the optical dispersion kernel based on the measured image array.

The measured image arrangement is the sum of the primary dose component and the optical scattering component, and optical scattering is the convolution of the primary dose component and the light scattering kernel.

The step (S170) of reconstructing the plurality of images obtained by the computer into a three-dimensional image by using the rotation angles includes a plurality of images captured by the computer at each rotation angle and the plurality of images obtained from the plurality of cameras. It is reconstructed into a three-dimensional image using the rotation angle.

Reconstructing the image into a 3D image using the rotation angle obtains an accurate value obtained by measuring the rotation angle of the rotating body 20 when the image is acquired, and reconstructs the image into a 3D image based on the rotation angle.

In computered tomography (CT), by using the same method as three-dimensional reconstruction by a plurality of projection images, a plurality of images simultaneously captured by a plurality of cameras at each rotation angle of the rotating body. Reconstruct into a three-dimensional image using an image.

The reconstruction algorithm for generating a 3D image using the rotation angle may be included regardless of the type, but preferably includes the FDK algorithm.

6 is a diagram illustrating a method of measuring a 3D dose distribution by comparing and analyzing the 3D dose distribution according to the present invention.

Referring to FIG. 6, in the method of measuring a three-dimensional dose distribution according to an embodiment of the present invention, a step of displaying a three-dimensional dose distribution by a computer using a look-up table (S190) and a three-dimensional dose distribution and calculation measured by the computer It further includes comparing and analyzing the three-dimensional dose distribution (S210).

In step S190, the computer indicates a three-dimensional dose distribution using a look-up table, the computer uses a look-up table to convert the pixel values of the reconstructed three-dimensional image into a dose value. It represents the dose distribution.

In this case, the lookup table is shown by allocating dose values to pixel values using 3D images for a plurality of doses. The remaining doses that could not be measured other than a plurality of measured doses are calculated through interpolation to construct a lookup table.

By using a lookup table that has already been made through experiments, it is possible to represent a 3D dose distribution based on a reconstructed 3D image.

The step of comparing and analyzing the measured 3D dose distribution and the calculated 3D dose distribution by the computer (S210) includes the measured 3D dose distribution displayed using a plurality of images measured by the computer, and a patient treatment system (treatment planning system). It compares and analyzes the calculated three-dimensional dose distribution calculated through.

To compare and analyze the measured 3D dose distribution and the calculated 3D dose distribution, by comparing the 3D dose distribution calculated with the already verified software, how accurate the measured 3D dose distribution value is and whether it can be used clinically. I can judge.

In an embodiment, by comparing the gamma index values, the measurement 3D dose distribution may be analyzed.

By comparing the measured 3D dose distribution and the calculated 3D dose distribution, if the two values match more than a predetermined range, it can be determined that it is clinically usable.

For example, if the predetermined range is 95% or more, the measured 3D dose distribution and the calculated 3D dose distribution are compared, and if 95% or more match, it is determined that it is clinically usable.

The predetermined range may be set by a user of the method of the present invention or may be set by a method manufacturer of the present invention.

The steps of a method or algorithm described in connection with an embodiment of the present invention may be implemented directly in hardware, implemented as a software module executed by hardware, or a combination thereof. Software modules include Random Access Memory (RAM), Read Only Memory (ROM), Erasable Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), Flash Memory, hard disk, removable disk, CD-ROM, or It may reside on any type of computer-readable recording medium well known in the art to which the present invention pertains.

In the above, embodiments of the present invention have been described with reference to the accompanying drawings, but those of ordinary skill in the art to which the present invention pertains can be implemented in other specific forms without changing the technical spirit or essential features. You can understand. Therefore, the embodiments described above are illustrative in all respects, and should be understood as non-limiting.

10: phantom module
11-1, 11-2: Phantom
12-1, 12-2: fluorescent plate
20: rotating body
30-1, 30-2: multiple cameras
40: linear accelerator

Claims (11)

A phantom module having a fluorescent plate disposed in the center and receiving radiation provided from the linear accelerator;
A rotating body installed under the phantom module to rotate the phantom while supporting the phantom, and rotating in a direction perpendicular to the radiation irradiation direction of the linear accelerator; And
Radiation is irradiated to the phantom module from the linear accelerator, and includes a plurality of cameras for obtaining converted light through the fluorescent plate of the phantom module when the rotating body rotates,
In the semi-cylindrical acrylic phantom of the phantom module, a groove for arranging the fluorescent plate is provided,
An optical grease formed to prevent total reflection of radiation incident on the phantom module is further provided in the groove,
3D dose distribution measurement system. delete The method of claim 1,
The phantom module,
Including two semi-cylindrical acrylic phantoms of the same size and a fluorescent plate,
The two acrylic phantoms are combined to form a cylindrical shape, but each fluorescent plate is disposed on a flat portion of the two acrylic phantoms,
In the fluorescent plate, the portion containing the phosphor is disposed in a direction toward the circular portion of the semi-cylindrical acrylic phantom,
3D dose distribution measurement system. delete The method of claim 1,
The rotating body,
In the case where the linear accelerator is rotatable, it includes rotating in the same axis as the irradiation direction of radiation due to a position change of the linear accelerator,
3D dose distribution measurement system. The method of claim 1,
The plurality of cameras are arranged at intervals of a predetermined angle,
3D dose distribution measurement system. The method of claim 1,
Further comprising an image processing unit for processing the plurality of images acquired through the plurality of cameras to reconstruct a three-dimensional image,
The image processing unit,
Correcting the distortion of the camera for the obtained plurality of images,
Removing scattering components for the plurality of images,
Reconstructing a three-dimensional image by using a plurality of images taken at each rotation angle from the plurality of cameras and the rotation angle of the obtained plurality of images,
3D dose distribution measurement system. The method of claim 7,
Further comprising an analysis unit for analyzing a three-dimensional dose distribution using the reconstructed three-dimensional image,
The analysis unit,
A three-dimensional dose distribution is represented by using a look-up table representing a pixel value of the reconstructed three-dimensional image as a dose value,
Compare and analyze the measured 3D dose distribution displayed by using the measured plurality of images and the calculated 3D dose distribution calculated through the patient treatment system (treatment planning system),
The lookup table is represented by assigning a dose value to a pixel value using a three-dimensional image for a plurality of doses,
3D dose distribution measurement system. The computer acquires a plurality of images, wherein the plurality of images are prevented from total reflection by the optical grease provided in the groove of the phantom module, and the plurality of images are caused by the light emitted from the fluorescent plate of the phantom module. Acquiring a plurality of images that are obtained with the camera of the;
Correcting, by the computer, distortion of the camera for the acquired plurality of images;
The computer removing scattering components from the plurality of images; And
Comprising the step of reconstructing, by the computer, a three-dimensional image using a plurality of images taken for each rotation angle from the plurality of cameras and the rotation angle of the obtained plurality of images,
3D dose distribution measurement method. The method of claim 9,
Displaying, by the computer, a three-dimensional dose distribution using a look-up table for converting pixel values of the reconstructed three-dimensional image into dose values; And
The computer further comprises the step of comparing and analyzing the measured 3D dose distribution displayed using the measured images and the calculated 3D dose distribution calculated by the patient treatment system (treatment planning system),
The lookup table is represented by assigning a dose value to a pixel value using a three-dimensional image for a plurality of doses,
3D dose distribution measurement method. A computer program for measuring a three-dimensional dose distribution, combined with a computer that is hardware, and stored in a medium for executing the method of any one of claims 9 and 10.

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