KR102157266B9 - Perimysium-scaled heart on a chip and uses thereof - Google Patents

Perimysium-scaled heart on a chip and uses thereof

Info

Publication number
KR102157266B9
KR102157266B9 KR1020190151501A KR20190151501A KR102157266B9 KR 102157266 B9 KR102157266 B9 KR 102157266B9 KR 1020190151501 A KR1020190151501 A KR 1020190151501A KR 20190151501 A KR20190151501 A KR 20190151501A KR 102157266 B9 KR102157266 B9 KR 102157266B9
Authority
KR
South Korea
Prior art keywords
perimysium
chip
scaled
heart
scaled heart
Prior art date
Application number
KR1020190151501A
Other languages
Korean (ko)
Other versions
KR102157266B1 (en
Inventor
고성호
최건호
김기석
이재혁
Original Assignee
차의과학대학교 산학협력단
한국화학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 차의과학대학교 산학협력단, 한국화학연구원 filed Critical 차의과학대학교 산학협력단
Priority to KR1020190151501A priority Critical patent/KR102157266B1/en
Application granted granted Critical
Publication of KR102157266B1 publication Critical patent/KR102157266B1/en
Priority to PCT/KR2020/016469 priority patent/WO2021101313A1/en
Publication of KR102157266B9 publication Critical patent/KR102157266B9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020190151501A 2019-11-22 2019-11-22 Perimysium-scaled heart on a chip and uses thereof KR102157266B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020190151501A KR102157266B1 (en) 2019-11-22 2019-11-22 Perimysium-scaled heart on a chip and uses thereof
PCT/KR2020/016469 WO2021101313A1 (en) 2019-11-22 2020-11-20 Cardiac perimysium-level biomimetic heart-on-a-chip and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020190151501A KR102157266B1 (en) 2019-11-22 2019-11-22 Perimysium-scaled heart on a chip and uses thereof

Publications (2)

Publication Number Publication Date
KR102157266B1 KR102157266B1 (en) 2020-09-18
KR102157266B9 true KR102157266B9 (en) 2022-01-17

Family

ID=72670345

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020190151501A KR102157266B1 (en) 2019-11-22 2019-11-22 Perimysium-scaled heart on a chip and uses thereof

Country Status (2)

Country Link
KR (1) KR102157266B1 (en)
WO (1) WO2021101313A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102157266B1 (en) * 2019-11-22 2020-09-18 차의과학대학교 산학협력단 Perimysium-scaled heart on a chip and uses thereof
CN113447548A (en) * 2021-06-09 2021-09-28 华东师范大学 Construction method of biological sensing system for detecting physiological and pathological parameters of organ chip
KR20230110153A (en) * 2022-01-14 2023-07-21 주식회사 휴먼에이스 Human tissues-on-chips with inverted-microweir structures and uses thereof
KR20230110031A (en) 2022-01-14 2023-07-21 주식회사 휴먼에이스 Organ-on-a-chips with inverted-microweir structures comprising collagen layer and uses thereof
WO2024025177A1 (en) * 2022-07-25 2024-02-01 주식회사 휴먼에이스 Organ-on-a-chip having inverted micro-weir, and use thereof
CN118010946A (en) * 2024-04-08 2024-05-10 四川里来思诺生物科技有限公司 Drug stability detection method and system in bionic environment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050981A1 (en) * 2010-09-29 2012-04-19 Massachusetts Institute Of Technology Device for high throughput investigations of cellular interactions
WO2013061849A1 (en) * 2011-10-28 2013-05-02 国立大学法人東京医科歯科大学 Method and device for examining myocardial toxicity and evaluating cardiomyocyte
KR101426056B1 (en) 2013-04-08 2014-08-01 서울대학교산학협력단 Device for in vitro blood vessel formation and vascular permeability assay using the same
KR101644635B1 (en) 2014-05-30 2016-08-03 서울대학교산학협력단 Microfluidic chip for generating microvessel and a method for analyzing cancer metastasis using thereof
US20180273904A1 (en) * 2015-10-02 2018-09-27 Wake Forest University Health Sciences Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same
KR101916393B1 (en) * 2016-09-08 2018-11-08 한국화학연구원 in vitro cardiotoxicity testing using human pluripotent stem cell-derived cardiomyocytes
KR101964918B1 (en) 2017-10-17 2019-04-02 연세대학교 산학협력단 Apparatus and method for generating heart model based on heart voltage map and voltage activation map
KR102157266B1 (en) * 2019-11-22 2020-09-18 차의과학대학교 산학협력단 Perimysium-scaled heart on a chip and uses thereof

Also Published As

Publication number Publication date
KR102157266B1 (en) 2020-09-18
WO2021101313A1 (en) 2021-05-27

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