KR102145033B1 - Manufacturing method for medical diagnostic sheet - Google Patents

Abstract

The present invention relates to a medical diagnostic sheet, which performs in vitro diagnostics to confirm infection of blood sugar, acquired immunodeficiency syndrome (AIDS), bowel disease, and other diseases with biological samples such as blood, manure, body fluid and the like, and in particular, to a method for manufacturing a medical diagnostic sheet, which secures precision of each punching hole or a fine link slit by manufacturing various punching holes on an external medical diagnostic sheet that acts as a support for wrapping an inner test paper with reagents or the like through primary and secondary punching processes. The method for manufacturing a medical diagnostic sheet according to the present invention comprises, when punching so that punching holes are formed in a diagnostic sheet formed by adhering a lower base film, an intermediate diagnostic paper, and an upper protective film: (a) a primary punching process of punching and forming a link slit including an upper horizontal head slit and vertical tail slit in a similar shape to an alphabet T; and (b) a secondary punching process of forming a diagnostic main hole set by punching a plurality of circles on upper and lower parts of the horizontal head slit, and simultaneously forming diagnostic sub-holes by punching one circle on a lower end of the vertical tail slit. The horizontal head slit of the link slit formed in the primary punching process has a branch slit for connecting each main hole of the main hole set on the upper and lower parts to the horizontal head slit, and the main hole set and the sub-holes communicate with each other by the link slit.

Description

Manufacturing method of medical diagnostic sheet {MANUFACTURING METHOD FOR MEDICAL DIAGNOSTIC SHEET}

The present invention relates to a method of manufacturing a medical diagnostic sheet,

In more detail, medical diagnostic sheets, especially reagents, that perform in vitro diagnostics to check for infection of blood sugar, acquired immunodeficiency syndrome (AIDS, AIDS), bowel disease, and other diseases are provided as biological samples such as blood, manure, and body fluid. A medical diagnostic sheet that secures the precision of each punching hole or fine link slit and reduces the defect rate by manufacturing various punching holes through the primary and secondary punching processes on an external medical diagnostic sheet that serves as a support for wrapping the inner test paper. It relates to a method of manufacturing.

As a technology for a conventional medical diagnostic sheet, there is Patent Registration No. 10-0020350 (registration date December 3, 1985) [Method of manufacturing test paper for blood glucose measurement],

This registered patent relates to a method of manufacturing a new and advanced blood glucose measurement test paper that can quickly and accurately measure the glucose content in blood,

0.05% of a solution of a mixture of a semi-permeable polymer and 15% polyvinyl alcohol as a stabilizer in a known mixed solution for enzymatic measurement of glucose content containing glucose oxidase, peroxidase, and colorants, orthotolidine and bedidine. A fabrication technique is proposed in which a thin film is formed on the surface of a cellulose filter paper pretreated with an ethyl cellulose alcohol solution, and then dried to form a thin film. Then, a 0.01% ethyl cellulose alcohol solution is further post-treated and dried.

In addition, there is Patent Registration No. 10-1555905 (registration date September 21, 2015) [automatic slitting and dispensing machine for blood glucose measurement test paper].

This registered patent elaborately slits a blood glucose measurement test strip contained in a tray by cross rotation of a slitting knife installed at each corresponding point up and down through an automatic slitting function, and the slitting blood vessel measurement test strip is defective. A mechanical device that can precisely discriminate whether or not to make it easy to store or distribute blood vessel test papers is proposed.

Then there is Patent Registration No. 10-1773418 (registration date August 25, 2017) [Test paper for self-diagnosis of blood glucose and blood glucose self-diagnosis method using the same].

This registered patent is a blood sugar self-diagnosis test paper and a blood sugar self-diagnosis test paper that checks blood sugar using a diagnostic test strip in which a blood strip and a urine test strip are packaged, and obtains an accurate blood sugar value quantified through a blood sugar analysis application provided on a smartphone. It relates to a method for self-diagnosing blood sugar using the same.

In addition, there is Patent Publication No. 10-2017-0060679 (published date June 2, 2017) [Method of manufacturing hydrophilic film for blood glucose measurement strip],

This registered patent relates to a method of manufacturing a hydrophilic film for a blood glucose measurement strip that can increase adhesion without a separate additional step when a hydrophilic film is prepared by mixing a surfactant and a solvent, and when coated on a base film, more specifically It is proposed a technology that improves adhesion to each layer of the strip without a step such as plasma treatment or corona treatment on the base film, allows blood to move at a constant speed in the strip, and keeps the scatter low.

However, the conventional techniques, including these known documents, are related to the manufacturing method of the inner test paper itself equipped with reagents or reagents, or the slitting and packing of the completed medical diagnostic sheet, so it is far from the present invention related to punch punching. .

Accordingly, the present invention is provided with a medical diagnostic sheet, especially reagents, for performing in vitro diagnosis to check whether blood sugar, acquired immunodeficiency syndrome (AIDS, AIDS), bowel disease, or other diseases are infected with biological samples such as blood, manure, and body fluid. A medical diagnostic sheet that secures the precision of each punching hole or fine link slit and reduces the defect rate by manufacturing various punching holes through the primary and secondary punching processes on an external medical diagnostic sheet that serves as a support for wrapping the inner test paper. It aims to provide a manufacturing method of.

In addition, the present invention punches a link slit including an upper horizontal head slit and a vertical tail slit of an alphabet T-like type through a first punching process, and includes a diagnostic main hole set and a diagnostic sub-hole through the second punching process. The purpose of this is to ensure smooth in vitro diagnosis by forming punching holes to manufacture punched parts, and making each diagnosis punching hole communicate with each other by a link slit.

Further, in the present invention, the punching in (a) the first punching process and (b) the second punching process is a punching laminated sheet composed of a diagnostic paper and a protective film, and the base film is composed of a thicker material than the protective film. And to ensure safe punching.

In addition, the present invention aims to make the vertical tail slit of the link slit consist of a curved slit so that blood or other bodily fluid flows into the main hole set or sub-hole at an appropriate speed and capacity as the diagnostic sheet is tilted during in vitro diagnosis. .

Next, an object of the present invention is to adjust the width of the base film, the diagnostic paper, and the protective film so that the inner test paper can be mounted, slitting, and packing (bottling, etc.) smoothly.

In order to achieve the above object, the method of manufacturing a medical diagnostic sheet according to the present invention

In punching so that a punching hole is formed in the diagnostic sheet composed of the lower base film, the intermediate diagnostic paper, and the upper protective film,

(a) a first punching step of punching and forming a link slit including an upper horizontal head slit and a vertical tail slit of the letter T-like type; And

(b) a second punching process of forming a diagnostic main hole set by perforating a plurality of circles above and below the horizontal head slit, and simultaneously forming a diagnostic sub-hole by drilling one circle at the bottom of the vertical tail slit; ,

Of the link slits formed in the primary punching process, the horizontal head slit has a branch slit connecting each of the main holes of the upper and lower main hole sets with the horizontal head slit,

It is characterized in that the main hole set and the sub hole are communicated with each other by a link slit.

In addition, in the manufacturing method of the medical diagnostic sheet according to the present invention

Punching in the (a) first punching process and (b) the second punching process is a punching laminated sheet composed of diagnostic paper and protective film,

The base film is thicker than the protective film,

The vertical tail slit of the link slit is a curved slit,

The link slit has a width of 0.5 mm or less, and the main hole set and the sub-hole have an area corresponding to a circle having a diameter of 1.0 mm or more,

The base film and the protective film have a length, and the base film has a larger width than the protective film,

The diagnostic paper is omitted at both ends of the diagnostic sheet, so that a plurality of conveying holes are formed apart in the longitudinal direction, and a protective laminate sheet formed by adhesion between the base film and the protective film is formed. Is formed in, and some of the transfer holes are formed in the protective film,

In the second punching process (b), a handling slot on the upper part of the main hole set is formed in the punching laminated sheet composed of diagnostic paper and protective film, and transfer holes located inside the transfer hole are formed on both left and right sides of the punching laminated sheet. It is desirable to be.

The manufacturing method of the medical diagnostic sheet according to the present invention is to punch-form a link slit including an upper horizontal head slit and a vertical tail slit similar to the letter T through a first punching process, and a main hole for diagnosis through a second punching process. A punching part is formed by forming a punching hole including a set and a diagnosis sub-hole, and each punching hole for diagnosis is communicated by a link slit to ensure smooth in vitro diagnosis, and further (a) the first punching process and ( b) Punching in the second punching process is a punching laminated sheet composed of diagnostic paper and a protective film, and the base film is made of thicker than the protective film to ensure smooth and safe punching, and also the link slit The vertical tail slit is composed of a curved slit, and it is possible to allow blood or other body fluids to flow into the main hole set or sub-hole at an appropriate speed and volume by tilting the diagnostic sheet during in vitro diagnosis. Next, the base film, diagnostic paper, and By adjusting the width of the protective film, the inner test paper can be installed, slitting, and packing (bottling, etc.) smoothly. Eventually, blood sugar and acquired immunodeficiency syndrome (AIDS, AIDS) are used as biological samples such as blood, manure, and body fluids. , A variety of punching holes in the first and second medical diagnostic sheets that perform in vitro diagnostics to check for infection of colon diseases, and other diseases, especially the external medical diagnostic sheet that acts as a support to wrap the inner test paper with reagents, etc. By manufacturing through a punching process, the precision of each punching hole or fine link slit can be secured and the defect rate can be reduced.

1 is a complete diagram of a diagnostic sheet completed through a method of manufacturing a medical diagnostic sheet according to the present invention.
Figure 2 is a partial enlarged view of a medical diagnostic sheet according to the present invention.
3 is a conceptual diagram of a vertical tail slit among link slits that allow blood or other body fluids to flow into a main hole set or sub-hole at an appropriate speed and capacity after individual slitting of the medical diagnostic sheet according to the present invention.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The present invention will be described in detail in the text of the bar, implementation (態樣, aspect) (or embodiment) that can apply various changes and have various forms. However, this is not intended to limit the present invention to a specific form of disclosure, it should be understood to include all changes, equivalents, and substitutes included in the spirit and scope of the present invention.

In each drawing, the same reference numerals, in particular the number of tens and ones, or the same number of tens, ones, and alphabet indicate members having the same or similar functions, and unless otherwise specified, each of the drawings The member indicated by the reference number can be identified as a member conforming to these criteria.

In addition, in each drawing, in consideration of the convenience of understanding, the components are exaggeratedly large (or thick) or small (or thin) or simplified and expressed in terms of size or thickness, but the scope of protection of the present invention is limited by this. It shouldn't be.

The terms used in the present specification are only used to describe specific embodiments (sun, 態樣, aspect) (or embodiments), and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In the present application, terms such as ~include~ or ~consist~ are intended to designate the existence of features, numbers, steps, actions, components, parts, or a combination thereof described in the specification, but one or more other features It is to be understood that the presence or addition of elements or numbers, steps, actions, components, parts, or combinations thereof, does not preclude in advance the possibility of being added.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs. Terms as defined in a commonly used dictionary should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and should not be interpreted as an ideal or excessively formal meaning unless explicitly defined in this application. Does not.

In the present specification, when it is determined that detailed descriptions of known functions and configurations may unnecessarily obscure the subject matter of the present invention, a description thereof may be omitted.

The ~1~, ~2~, etc. described in the present specification will only be referred to to distinguish different components, etc., and are not limited to superiority or inferiority or the order of manufacture, and in the detailed description of the invention and the claims The names may not match.

In describing the method of manufacturing a medical diagnostic sheet according to the present invention, for convenience, a rough approximate direction standard is specified with reference to FIGS. 1 to 3,

Unless otherwise noted, the directions are specified and described by dividing up and down, left and right, and before and after in the state as shown.

First, as shown in Figs. 1 and 2, the medical diagnosis sheet (S) completed by punching is a diagnosis consisting of a lower base film 10, an intermediate diagnosis paper 20, and an upper protective film 30 attached thereto. It is drafted using sheets.

Specifically, the method of manufacturing a medical diagnostic sheet according to the present invention relates to a processing method of an external medical diagnostic sheet serving as a support for wrapping an inner test paper provided with a reagent or the like.

Afterwards, the process of mounting, slitting and packing (bottling, etc.) of the inner test paper is in progress.

The manufacturing method of the medical diagnostic sheet (S) according to the present invention is manufactured through (a) the first punching process and (b) the second punching process, through which each punching hole is manufactured through the first and second punching processes. It is possible to secure the precision of the punching portion of the back, particularly the fine link slit, and to reduce the defect rate.

(a) In the first punching process, a link slit 51 including an upper horizontal head slit 51a and a vertical tail slit 51b of an alphabet T-like type is punched and formed,

Further, of the link slits 51 formed in this primary punching process, the horizontal head slit 51a includes (b) each of the main holes 53 of the upper and lower main hole sets 53S formed in the secondary punching process. A branch slit 51c connecting to 51a) is further formed.

Next, (b) in the second punching process, a plurality of circles above and below the horizontal head slit 51a

(If necessary, other shapes of perforations are possible, and this should also be interpreted as belonging to the protection scope of the present invention. In the present specification and claims, the formation of the punching portion SP is a link such as a curved vertical tail slit 51b Except for the slit 51, the protection range should not be limited by a limited shape such as "circle".)

The diagnostic main hole 53 is formed by perforating the set 53S, and at the same time, one circle is punched at the bottom of the vertical tail slit 51a to form the diagnostic sub-hole 55.

The diagnostic main hole set 53S and the sub hole 55 are communicated with each other by a link slit 51.

Furthermore, punching in the (a) first punching process and (b) the second punching process is a punching laminate sheet (S1) composed of a diagnostic paper 20 and a protective film 30, and the base film 10 is not punched. Does not. In addition, the base film 10 is thicker than the protective film 30 so that it is not perforated to the base film by the Thompson mold during punching.

If necessary, the base film 10, the protective film 30, and the trimming film 40 are made of various synthetic resin films such as PET, PP, PC, and PE, and the diagnostic paper 20 is also made of simple paper types or synthetic resins. Paper can be used, and coating layers can be introduced on both sides if necessary.

On the other hand, the link slit 51 composed of the horizontal head slit 51a, the vertical tail slit 51b and the branch slit 51c has a width of 0.5 mm or less, and the main hole set and the sub-hole have a diameter of 1.0 mm or more. It is possible to have an area corresponding to a circle (which may not be a garden) so that blood or other body fluids flow from subhole to mainhole set or from mainhole set to subhole at an appropriate speed and volume.

Furthermore, if the inner test paper is installed and slitting is completed,

As shown in Fig. 3, which is a conceptual diagram of the use of a vertical tail slit among link slits that allow blood or other bodily fluid to flow into the main hole set or sub-hole at an appropriate speed and capacity after individual slitting of the medical diagnostic sheet according to the present invention ( For convenience of understanding, only one medical diagnostic sheet according to the present invention is shown),

The vertical tail slit 51b of the link slit 51 is a curved slit,

For example, according to an appropriate inclination of about 15 degrees clockwise ([B]) or counterclockwise ([C]) in Fig. 3 [A]

It is a reagent of the inner test paper provided in the lower part of the subhole 55 in the main hole set 53S in which blood or other bodily fluid is at an appropriate speed and volume,

Alternatively, it is possible to flow from the sub-hole 55 to the reagent of the inner test paper (not shown) of the main hole set 53S.

Next, in the diagnostic sheet (S) that is punched and punched (having a punching part (SP) of 10 rows x 5 rows)

The base film 10 and the protective film 30 constituting the protective laminate sheet (S2) have a length,

The base film 10 has a larger width than the protective film 30,

The diagnostic paper 20 is omitted at both ends of the diagnostic sheet S, so that a plurality of transfer holes SH are formed spaced apart in the longitudinal direction,

It constitutes a protective laminate sheet (S2) formed by adhesion of the base film 10 and the protective film 30,

In the protective laminate sheet (S2), the transfer hole (SH) is formed in a relatively thick base film 10, it is preferable that some of the transfer holes are formed in the protective film 30 or not formed at all.

In addition, (b) in the second punching process, the punching laminate sheet (S1) composed of the diagnostic paper 20 and the protective film 30 has a handling slot on the top of each main hole set (53S), especially two handling slots of a square-like structure. 57 is formed,

The transfer hole (sh) located inside the transfer hole (SH) is further formed on both left and right sides of the punched laminate sheet (S1),

Thereafter, the transfer hole (sh) or the handling slot 57 may be used in the mounting or slitting process of the inner test paper.

Each conveying hole (SH) is used for conveying by inserting a conveyor belt pin, and either (a) outsourcing before the 1st punching process, or (a) the 1st punching process and (b) the main manufacturing for the 2nd punching process. The method can be formed at the entrance of the Thompson mold.

Further, as shown in the schematic diagram in the upper one-dot chain circle in Fig. 2 [B] (a schematic diagram showing the outline of the laminated base film, diagnostic paper, protective film, and trimming film), (a) 1 chart A separate trimming film 40 may be further combined on the protective film 30 in order to remove the punching bur of the fine link slit 51 after the footing process,

(a) After the first punching process, the trimming film 40 is removed to remove burrs generated during punching of the link slit 51 having a width of 0.5 mm or less, and then (b) the second punching process is performed.

(b) In the second punching process, punching holes 50 such as a main hole set and sub-holes having an area corresponding to a circle having a diameter of 1.0 mm or more are formed, so it is relatively easy to punch in the future by simply blowing strong wind. The burrs of the hole 50 can be removed.

The width of the trimming film 40 is narrower than that of the protective film 30 (the same as the width of the diagnostic paper 20 or may be narrower than the width of the diagnostic paper enough to cover the transfer hole sh), and the length of the base film 10 ), it is preferably configured to be longer than the diagnostic paper 20 and the protective film 20 so that the trimming film can be easily removed using the protruding longitudinal end portion during the transfer process using the conveyor belt.

In addition, it is preferable that an adhesive is applied to one or both sides of the diagnostic paper 20 for mounting the inner test paper thereafter,

Adhesive strength is

Adhesive strength between base film and diagnostic paper ＞ Adhesive strength between diagnostic paper and protective film ≥ Adhesive strength between protective film and trimming film

The relationship is suitable for the smooth progress of the installation, slitting and packing (bottling, etc.) of the inner test paper afterwards.

In the above description, specific specifications such as the size of medical diagnostic sheets and manufacturing methods, materials, and specific technologies such as mounting of inner test paper, slitting and packing (bottling, etc.) are omitted, but those skilled in the art can easily guess and deduce them. And reproduce.

In addition, in describing the present invention above, a medical diagnostic sheet having a specific shape and structure and a method of manufacturing the same have been mainly described with reference to the accompanying drawings, but the present invention can be variously modified, changed, and substituted by those skilled in the art. , Changes and substitutions should be construed as belonging to the protection scope of the present invention.

S: diagnostic sheet 10: base film
20: diagnostic paper 30: protective film
40: trimming film sp: punching part
50: punching hole 51: link slit
53S: main hole set 55: sub hole

Claims (4)

In punching so that a punching hole is formed in the diagnostic sheet composed of the lower base film, the intermediate diagnostic paper, and the upper protective film,
(a) a first punching step of punching and forming a link slit including an upper horizontal head slit and a vertical tail slit of the letter T-like type; And
(b) a second punching process of forming a diagnostic main hole set by perforating a plurality of circles above and below the horizontal head slit, and simultaneously forming a diagnostic sub-hole by drilling one circle at the bottom of the vertical tail slit; ,
Of the link slits formed in the primary punching process, the horizontal head slit has a branch slit connecting each of the main holes of the upper and lower main hole sets with the horizontal head slit,
A method of manufacturing a medical diagnostic sheet, characterized in that the main hole set and the sub hole are in communication with each other by a link slit. The method of claim 1,
Punching in the (a) first punching process and (b) the second punching process is a punching laminated sheet composed of diagnostic paper and protective film,
The method for manufacturing a medical diagnostic sheet, characterized in that the base film is thicker than the protective film. The method according to claim 1 or 2,
The method of manufacturing a medical diagnostic sheet, characterized in that the vertical tail slit of the link slit is a curved slit. The method of claim 3,
The link slit has a width of 0.5 mm or less, and the main hole set and the sub-hole have an area corresponding to a circle having a diameter of 1.0 mm or more,
The base film and the protective film have a length, and the base film has a larger width than the protective film,
The diagnostic paper is omitted at both ends of the diagnostic sheet, so that a plurality of conveying holes are formed apart in the longitudinal direction, and a protective laminate sheet formed by adhesion between the base film and the protective film is formed. Is formed in, and some of the transfer holes are formed in the protective film,
In the second punching process (b), a handling slot on the upper part of the main hole set is formed in the punching laminated sheet composed of diagnostic paper and protective film, and transfer holes located inside the transfer hole are formed on both left and right sides of the punching laminated sheet. A method for manufacturing a medical diagnostic sheet, characterized in that it is.

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