KR102141487B1 - Bio-degradable medical yarn having improved tensile strength and flexibility and manufacturing method thereof - Google Patents

Abstract

The disclosed content relates to a biodegradable surgeon with improved tensile strength and flexibility and a method for manufacturing the same, and more specifically, it is composed of a biodegradable polymer and an additive, and is a raw material mixture of polylactic acid and polycaprolactam, which are biodegradable polymers. Step, a first extrusion step of extruding the mixture prepared through the raw material mixing step with a twin screw extruder, an additive to be added to the mixture by adding an additive to the downstream side of the twin screw extruder during the first extrusion step Input step, a first cooling step of cooling the extrudate extruded through the additive injection step, a second extrusion step of extruding the cooled extrudate through the first cooling step using a single screw extruder and the second extrusion It is manufactured through a second cooling step of cooling the extrudate extruded through the step.
The biodegradable surgeon manufactured through the above ingredients and manufacturing method not only exhibits excellent biodegradability, but also has excellent tensile strength and flexibility, wrinkle improvement, skin whitening and antioxidant effects.

Description

Biodegradable surgeon with improved tensile strength and flexibility and its manufacturing method {BIO-DEGRADABLE MEDICAL YARN HAVING IMPROVED TENSILE STRENGTH AND FLEXIBILITY AND MANUFACTURING METHOD THEREOF}

The disclosed content relates to a biodegradable surgeon with improved tensile strength and flexibility, and a method for manufacturing the same, more specifically, exhibits excellent biodegradability, excellent tensile strength and flexibility, wrinkle improvement, skin whitening, and antioxidant effects. The present invention relates to a biodegradable surgeon with improved tensile strength and flexibility and a method for manufacturing the same.

In accordance with the trend of increasing interest in beauty, modern society has appeared in various treatment methods to remove wrinkles on the face or neck, including facial lift, filler insertion, botulinum toxin injection and laser skin regeneration. It is mainly used.

Recently, a face lifting method has been developed and used to remove wrinkles by pulling skin tissue by inserting a special operator into the skin layer without incising the molded area.

Conventionally, since the procedure of removing the surgeon used for the procedure has to be performed after the face lifting procedure, not only the patient's pain is increased, but there is a troublesome problem, and to improve this, a surgeon made of biodegradable polymer is used. After the procedure, products that naturally decompose in the body have been developed and applied.

However, in the case of a biodegradable surgeon developed in the past, the mechanical properties such as tensile strength are excellent, but the flexibility is low, so it is difficult to show a universal effect because the surgical result depends on the skill of the operator, and the surgeon can be applied. There was a problem that the site is limited.

Korean Patent Registration No. 10-0679160 (January 30, 2007). Korean Patent Registration No. 10-1178871 (2012.08.27).

Disclosed is to provide an operator and a method of manufacturing the biodegradability, as well as excellent tensile strength and flexibility, wrinkle improvement, skin whitening and antioxidant effects.

As one embodiment, the contents of this disclosure are made of biodegradable polymers and additives, and the biodegradable polymers are for biodegradable surgeons with improved tensile strength and flexibility, which are made of polylactic acid and polycaprolactam. Is described.

Preferably, the biodegradable surgeon with improved tensile strength and flexibility may be composed of 100 parts by weight of biodegradable polymer and 1 to 3 parts by weight of additive.

More preferably, the biodegradable polymer may be made of 85 to 98% by weight of polylactic acid and 2 to 15% by weight of polycaprolactam.

More preferably, the additive may be made of at least one selected from the group consisting of thiamine tetrahydrofurfuryl disulfide and idebenone, and a curing agent and antioxidant.

As another example, the contents of this disclosure include a raw material mixing step of mixing polylactic acid and polycaprolactam, which are biodegradable polymers, a first extrusion step of extruding the mixture prepared through the raw material mixing step with a twin screw extruder, the agent 1 During the extrusion step, the additive is added to the mixture by adding an additive to the downstream side of the twin screw extruder, a first cooling step of cooling the extrudate extruded through the additive injection step, the first cooling Tensile strength and flexibility, characterized by comprising a second extruding step of extruding the extrudate cooled through the step using a single screw extruder and a second cooling step of cooling the extrudate extruded through the second extruding step. It describes a method for manufacturing an improved biodegradable surgeon.

Preferably, the additive may be made of at least one selected from the group consisting of thiamine tetrahydrofurfuryl disulfide and idebenone, and a curing agent and antioxidant.

More preferably, after the second cooling step, an ultraviolet irradiation step of irradiating ultraviolet rays to the extrudate cooled through the second cooling step may be further performed.

As described above, the biodegradable surgeon with improved tensile strength and flexibility and its manufacturing method not only exhibit excellent biodegradability, but also have excellent tensile strength and flexibility, and provide a surgeon with improved wrinkles, skin whitening and antioxidant effects. Exhibits an excellent effect.

1 is a flow chart showing a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility according to one disclosed embodiment.
2 is a flowchart illustrating a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility according to another disclosed embodiment.

Hereinafter, the preferred embodiment of the present invention and the physical properties of each component will be described in detail, but it is intended to be described in detail so that a person skilled in the art to which the present invention pertains can easily implement the invention. This does not mean that the technical spirit and scope of the present invention is limited.

The disclosed biodegradable surgeon with improved tensile strength and flexibility is made of biodegradable polymers and additives, and is preferably made of 100 parts by weight of the biodegradable polymers and 1 to 3 parts by weight of additives.

At this time, the biodegradable polymer is made of poly lactic acid (PLA, Poly Lactic Acid) and poly caprolactam (PCL, Poly Caprolactam).

The biodegradable polymer is a component that is a main material for a biodegradable surgeon with improved tensile strength and flexibility disclosed, consisting of polylactic acid and polycaprolactam, with 85 to 98% by weight of polylactic acid and 2 to 15% by weight of polycaprolactam. It is preferably made.

The polylactic acid serves to provide the surgeon with excellent tensile strength by imparting curability to the disclosed biodegradable surgeon with improved tensile strength and flexibility. When the content of the polylactic acid is less than 85% by weight, the tensile strength of the surgeon When the content of the polylactic acid exceeds 98% by weight, the ductility of the surgeon may decrease.

The polycaprolactam contains 2 to 15% by weight, and serves to provide an operator with excellent flexibility by imparting ductility to the disclosed biodegradable surgeon with improved tensile strength and flexibility, wherein the content of the polycaprolactam is If the content is less than 2% by weight, the above effect is negligible, and when the content of the polycaprolactam exceeds 15% by weight, the tensile strength of the surgeon may decrease.

The additive contains 1 to 3 parts by weight relative to 100 parts by weight of the biodegradable polymer, at least one selected from the group consisting of thiamine tetrahydrofurfuryl disulfide (TTFD) and idebenone and curing agent and antioxidant Is made of

In particular, the additive is preferably made of a mixture of thiamine tetrahydrofurfuryl disulfide and idebenone in an amount of 2: 1 by weight, further containing a curing agent and an antioxidant, and 1.5 parts by weight compared to 100 parts by weight of the biodegradable polymer. It is more preferably contained.

The thiamine tetrahydrofurfuryl disulfide is an active vitamin in the skin, and serves to impart wrinkle improvement, anti-aging and whitening effects. The idebenone exhibits wrinkle improvement and excellent skin whitening effect. If the content is less than 1 part by weight, the above effect is negligible, and when the content of the additive exceeds 3 parts by weight, the additive component is not evenly mixed with the biodegradable polymer, and clumping occurs, resulting in carbonization or surgery. The disconnection of death occurs.

In addition, the surgical agent containing the additive consisting of the above components is released during the process of decomposition in the body, the additive components showing wrinkle improvement, anti-aging and whitening effects are released to continuously impart anti-wrinkle, anti-aging and whitening effects to the skin. It becomes possible.

In addition, the curing agent contains 0.1 to 1 part by weight of the curing agent relative to 100 parts by weight of the biodegradable polymer, the antioxidant contains 0.1 to 1 part by weight of 100 parts by weight of the biodegradable polymer, the curing agent is applied to the biodegradable polymer Any component that can be used is not particularly limited, and any one can be used, but it is preferable that it is composed of at least one selected from the group consisting of glutaraldehyde, phthalaldehyde, sodium benzoate, and potassium persulfate. It is preferably made of corbic acid.

In addition, the disclosed method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility includes a raw material mixing step (S101) for mixing polylactic acid and polycaprolactam, which are biodegradable polymers, and a mixture prepared through the raw material mixing step (S101). First extruding step (S103) of extruding with a twin screw extruder, an additive injection step (S105) of adding an additive to the mixture by adding an additive to the downstream side of the twin screw extruder during the first extruding step (S103), A first cooling step (S107) for cooling the extrudate extruded through the additive injection step (S105), and a second extrusion extruding the extrudate cooled through the first cooling step (S107) using a single screw extruder It consists of a second cooling step (S111) for cooling the extrudate through the step (S109) and the second extrusion step (S109).

The raw material mixing step (S101) is a step of mixing polylactic acid and polycaprolactam, which are biodegradable polymers, in which 85 to 98% by weight of polylactic acid and 2 to 15% by weight of polycaprolactam are added to a stirrer and 100 to 200 rpm. This is the mixing at speed.

At this time, since the description of the polylactic acid and polycaprolactam is the same as that described in the biodegradable surgeon with improved tensile strength and flexibility, a description thereof will be omitted.

The first extrusion step (S103) is a step of extruding the mixture prepared through the raw material mixing step (S101) with a twin screw extruder, and extruding the mixture produced through the raw material mixing step (S101) into a twin screw, The set temperature of the twirl screw is shown in Table 1 below.

<Table 1>

The additive injection step (S105) is a step in which the additive is added to the mixture by adding an additive to the downstream side of the twin screw extruder during the first extrusion step (S103), a separate side of the twin screw extruder It is a step of adding an additive composed of at least one selected from the group consisting of thiamine tetrahydrofurfuryl disulfide and idebenone, and a curing agent and an antioxidant by having an injector.

Since the additive component is carbonized or deteriorated due to conditions such as high temperature and high pressure while passing through the twin screw extruder when the additive component is introduced from the beginning of the first extrusion step (S103), the twin screw extruder may be lost. When the extruded product is provided with a feeder at a point where more than half of the extrudate is extruded, carbonization or deterioration of the additive component is suppressed, and at the same time, an extrudate in which the additive components are evenly mixed is provided.

At this time, the downstream side of the extruder refers to a point 1/2 in the direction close to the die among the feeder and the die, and the content of the additive component and the curing agent and the antioxidant, the component ratio and effect, etc. Since the tensile strength and flexibility are the same as those described in the biodegradable surgeon, the description thereof will be omitted.

The first cooling step (S107) is a step of cooling the extrudate extruded through the additive injection step (S105). It is a step of cutting into size and manufacturing in pellet form.

The second extrusion step (S109) is a step of extruding the extrudate cooled through the first cooling step (S107) using a single screw extruder, and extrudate cooled through the first cooling step (S107). It is a step of extruding with a single screw and pulling it out in the form of a thread. At this time, the cylinder set temperature of the single screw and the rotational speed of the winder are shown in Table 2 below.

<Table 2>

The second cooling step (S111) is a step of cooling the extrudate extruded through the second extrusion step (S109), and the extrudate extruded in the form of a thread through the second extrusion step (S109) as cooling water. This is a step of cooling through.

In addition, after the second cooling step (S111), an ultraviolet irradiation step (S113) may be further performed by irradiating ultraviolet rays to the extrudate cooled through the second cooling step (S111) to further improve the mechanical properties of the operator. , The second cooling step (S111) has a wavelength of 300 to 450nm on the surface of the extrudate cooled in the form of a thread, and irradiated with ultraviolet rays for 1 minute at a dosage of 72mW/cm ² per second to further improve the mechanical strength of the extrudate It is a step to do.

When the surface of the extrudate containing a component such as a curing agent input in the additive injection step (S105) is exposed to ultraviolet rays, the degree of curing may be shaped to improve mechanical strength such as tensile strength.

Hereinafter, a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility and a physical property of a biodegradable surgeon with improved tensile strength and flexibility prepared through the manufacturing method will be described as an example.

<Example 1>

98% by weight of polylactic acid and 2% by weight of polycaprolactam were added to a stirrer and stirred at a rate of 150 rpm for 10 minutes to prepare a mixture, and the resulting mixture was put into a twin screw extruder and extruded, but extruded into a twin screw extruder cylinder. When water is located at 2/3 point, 1 part by weight of thiamine tetrahydrofurfuryl disulfide, 0.5 part by weight of idebenone, 0.5 part by weight of curing agent (glutaraldehyde) through 100 parts by weight of the mixture through an injector provided in the twin screw extruder 0.5 parts by weight of a portion and an antioxidant (ascorbic acid) is added and extruded into a mixture with the mixture, cooled with cooling water and cut into 0.5 millimeter lengths to produce pellets, and the prepared pellets are put into a single screw extruder After extruding in the form of a thread and cooling with cooling water, ultraviolet (with a wavelength of 400nm, irradiated amount of 72mW/cm ² per second) is irradiated for 1 minute to improve the tensile strength and flexibility of 0.3 mm in diameter to improve biodegradability. Was prepared.

<Example 2>

Proceeding in the same manner as in Example 1, a biodegradable surgeon with improved tensile strength and flexibility was prepared using a mixture consisting of 95% by weight of polylactic acid and 5% by weight of polycaprolactam.

<Example 3>

Proceeding in the same manner as in Example 1, a biodegradable surgeon with improved tensile strength and flexibility was prepared using a mixture consisting of 90% by weight of polylactic acid and 10% by weight of polycaprolactam.

<Example 4>

Proceeding in the same manner as in Example 1, a biodegradable surgeon with improved tensile strength and flexibility was prepared using a mixture consisting of 85% by weight of polylactic acid and 15% by weight of polycaprolactam.

The tensile strengths prepared through Examples 1 to 4 and the tensile strength of the biodegradable surgeon with improved flexibility are measured and are shown in Table 3 below.

(However, the tensile strength was measured using the test method of KS F 2405, and the standard of the tensile load of the surgical suture should have a tensile load of ≥3.90kgf according to the USP standard. , Surgical sutures with a diameter of 0.20 to 0.249 mm should have a tensile load of ≥1.77kgf, surgical sutures with a diameter of 0.1 to 0.149mm should have a tensile load of ≥0.65kgf, and a diameter of 0.07 to 0.099mm Surgical sutures should have a tensile load of ≥0.30kgf.)

<Table 3>

As shown in Table 1 above, the surgeons prepared through the manufacturing method of the biodegradable surgeon with improved tensile strength and flexibility prepared through the disclosed Examples 1 to 4, as well as satisfying all of the criteria of the surgical suture, It can be seen that it exhibits excellent tensile strength.

In addition, the polycaprolactam exhibiting ductility is included to improve flexibility, and the additive components thiaminetetrahydrofurfuryldisulfide and idebenone are included to improve wrinkles, skin whitening and antioxidant effects.

S101; Raw material mixing step
S103; First extrusion step
S105; Additive injection step
S107; 1st cooling stage
S109: second extrusion step
S111: Second cooling stage
S113; UV irradiation stage

Claims (7)

Made of biodegradable polymers and additives,
The biodegradable polymer is made of polylactic acid and polycaprolactam,
The additive contains a mixture of thiamine tetrahydrofurfuryldisulfide and idebenone in a weight ratio of 2:1, and
The additive is a biodegradable surgeon with improved tensile strength and flexibility, characterized in that contained in 1 to 3 parts by weight compared to 100 parts by weight of the biodegradable polymer.
The method according to claim 1,
The biodegradable surgeon with improved tensile strength and flexibility is a biodegradable surgeon with improved tensile strength and flexibility, comprising 100 parts by weight of a biodegradable polymer and 1 to 3 parts by weight of an additive.
The method according to claim 1 or 2,
The biodegradable polymer is a biodegradable surgeon with improved tensile strength and flexibility, characterized in that it consists of 85 to 98% by weight of polylactic acid and 2 to 15% by weight of polycaprolactam.
The method according to claim 1 or 2,
The additive is a biodegradable surgeon with improved tensile strength and flexibility, characterized in that it further contains a curing agent and an antioxidant.
A raw material mixing step of mixing polylactic acid and polycaprolactam which are biodegradable polymers;
A first extrusion step of extruding the mixture produced through the raw material mixing step with a twin screw extruder;
An additive injection step in which an additive is added to the mixture by adding an additive to the downstream side of the twin screw extruder during the first extrusion step;
A first cooling step of cooling the extrudate extruded through the additive injection step;
A second extrusion step of extruding the extrudate cooled through the first cooling step using a single screw extruder; And
It consists of; a second cooling step of cooling the extrudate extruded through the second extrusion step;
The additive contains a mixture of thiamine tetrahydrofurfuryldisulfide and idebenone in a weight ratio of 2:1, and
The additive is a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility, characterized in that contained in 1 to 3 parts by weight compared to 100 parts by weight of the biodegradable polymer.
The method according to claim 5,
The additive is a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility, characterized in that it further contains a curing agent and an antioxidant.
The method according to claim 5,
After the second cooling step, a method of manufacturing a biodegradable surgeon with improved tensile strength and flexibility, characterized in that an ultraviolet irradiation step of irradiating ultraviolet rays to the extrudate cooled through the second cooling step is further performed.

Images