KR102126930B1 - Composition for manufacturing artificial model for imaging, artificial model for imaging prepared therefrom and method for controlling intensity of image signal using the composition - Google Patents

Abstract

The present invention is a composition for forming an artificial model for imaging, comprising a base resin and silicone oil, an artificial model for imaging made with the composition and a computed tomography machine (CT) or magnetic resonance imaging machine (MRI), It relates to a method of adjusting the intensity of the video signal to control the content of the silicone oil of the composition. The artificial model for imaging using the composition can emit various image signals during CT or MRI, enabling clear image reading, and the manufacturing cost is also low, making it possible for medical and radiographic imaging devices or devices. It can be used in a variety of fields, such as quality assurance (QA) in development or radiation therapy.

Description

Composition for forming artificial model body for imaging, artificial body for imaging made therefrom, and method of adjusting image signal intensity using the composition TECHNICAL FIELD SIGNAL USING THE COMPOSITION}

The present invention relates to a composition for forming an artificial model for imaging, comprising a base resin and silicone oil, an artificial model for imaging using the composition, and a method for adjusting the intensity of the image signal.

An artificial object made to enable imaging on multiple imaging devices, such as magnetic resonance imaging (MRI) or computed tomography (CT) for research or therapeutic purposes on behalf of a real patient in the medical field The model body is called a phantom or an artificial model body for imaging. Multi-purpose or modality imaging artificial model that can be imaged from multiple imaging devices, rather than an artificial imaging imaging object, which was currently only available for imaging in a single imaging device when using an artificial imaging body for imaging. Sieve is commercially available.

In general, an anthropomorphic or non-human model artificial model body for imaging is made to be visualized in an imaging device operated according to different principles. According to the difference in operating principle of each imaging device, an artificial model for imaging The method of making the model body is different and the materials used are different.

Each original substance has a unique linear attenuation coefficient, and in the case of CT imaging devices, the amount of energy transferred and absorbed by the substance during the X-ray material transmission (Penetration) is absorbed (absorbed). It depends. At this time, the residual energy that is absorbed and remains reaches the detector part. Thereafter, the detected amount of energy is converted into an electrical signal, which is converted into a digital signal, and a look up table defining the digital image signal intensity for a pixel having the same position in the image as the signal incident on the detector is defined. The video signal is converted as a reference. The signal information thus obtained is represented in a 2D or 3D spatial coordinate and is made into a final CT image.

On the other hand, the MR image is imaged using the difference in T1 and T2 relaxation time in the electromagnetic field of atoms constituting the material, which is different from the imaging method and principle of the CT imaging device.

Therefore, in order to make an artificial model for imaging so that both CT and MRI imaging devices can be imaged at the same time, a signal regulator that can control the difference in the T1 and T2 relaxation time along with the difference in the line-sensing coefficient of the material can play an important role. To date, research has been conducted to produce an artificial model for multi-purpose imaging using various signal regulators.

Korean Registered Patent No. 0123109

An object of the present invention is to provide a composition for forming an artificial model for imaging, which is capable of adjusting the intensity of an image signal, and an artificial model for imaging produced by the composition.

In addition, the present invention provides a method of adjusting the intensity of an image signal photographed by CT or MRI using the composition.

1. A composition for forming an artificial model for imaging, comprising a base resin and silicone oil.

2. The composition of 1 above, wherein the silicone oil has a viscosity of 100 to 3000 cs, forming an artificial model for imaging.

3. The composition according to the above 1, comprising 60 to 90 parts by weight of the base resin and 10 to 40 parts by weight of silicone oil, for forming an artificial body for imaging.

4. The composition of 1 above, wherein the base resin comprises at least one of urethane resin and silicone resin.

5. The composition of 1 above, wherein the silicone oil comprises polydimethylsiloxane (PDMS).

6. An artificial model for imaging, made of the composition of any one of 1 to 5 above.

7. In the above 6, wherein the artificial model includes a plurality of sub-structures having different silicone oil content of the composition, artificial model for imaging.

8. Preparing an artificial model for imaging with the composition of any one of 1 to 5 above; And photographing the artificial model using a computed tomography machine (CT) or a magnetic resonance imaging machine (MRI) to control the image signal intensity of the captured image by controlling the amount of silicone oil in the composition. , How to adjust the video signal strength.

The composition for forming an artificial model for imaging according to the present invention may exhibit various image signal strengths according to the control of the content of silicone oil.

In the case of an artificial model for imaging, manufactured according to the present invention, an image capable of distinguishing various parts can be taken, and clear reading is possible.

FIG. 1 is a photograph of a composition for forming an artificial model for imaging, manufactured according to an embodiment of the present invention. FIG. 1(A) shows four clockwise from the upper left, Vytaflex 40, PMC-780 Dry, PMC-780 Wet, PMC-121/30, and FIG. 1(B) four clockwise from the upper left BoA, Smooth-Cast 45D, Smooth-Cast 300Q, Smooth-Cast 325. From the left of the four, the blending ratio is 27g + 27g + 6g (10%), 24g + 24g + 12g (20%), 21g + 21g + 18g (30%), 18g + 18g + 36g (40%) (topical) + Hardener + silicone oil (g)).
FIG. 2 is a photograph showing that a mold for a man-made artificial model body manufactured according to an embodiment of the present invention is manufactured.
Figure 3 is a photograph injecting the composition into the artificial mold model mold of the head (頭部) of a person manufactured according to an embodiment of the present invention.
4 is a graph showing the change in signal intensity value during CT imaging according to the content of PDMS in Examples (Vyta: Vytaflex 40, SC45D: Smooth-Cast 45D, SC300Q: Smooth-Cast 300Q, SC325: Smooth-Cast 325, PMC780D: PMC-780 Dry, PMC121: PMC-121/30, PMC780W: PMC-780 Wet).
Figure 5a (A) is a diagram showing the change in relaxation time T ₁ in the case where 20 parts by weight of PDMS is mixed (subject: curing agent: silicone oil = 24: 24: 12), (B) is 20 weight It is a graph showing the change in relaxation time T ₂ of the mixed case of negative PDMS (subject: curing agent: silicone oil = 24: 24: 12) for each example.
FIG. 5B (A) is a diagram showing the change in relaxation time T ₁ in the case where 30 parts by weight of PDMS is mixed (subject: curing agent: silicone oil = 21: 21: 18), and (B) shows 30 weight It is a graph showing the change in relaxation time T ₂ of the mixed case of negative PDMS (subject: curing agent: silicone oil = 21: 21: 18) for each example.
6 is a photograph of the specimens of Example 2-2(A), Example 2-3(B), Example 2-4(C), and Example 2-5(D) observed with an optical microscope (20 X 0.403 magnification).
Figure 7 shows the head model and the MRI and CT images of the head artificial body prepared according to the embodiment (a) artificial model photo, (b) MRI T ₁ relaxation time photo, (c) MRI T ₂ relaxation time And (d) CT images.

Hereinafter, the present invention will be described in detail.

The composition for forming an artificial model for imaging according to an embodiment of the present invention includes a base resin and a silicone oil.

Base resin refers to a common resin used for the production of artificial models for imaging (phantoms), which is a material that is easy to produce artificial models for imaging of desired shape and provides sufficient hardness to maintain its shape. Can. For example, it may be a urethane resin or a silicone resin, but is not limited thereto.

Further, the base resin may be a thermosetting type or a photo-curing type, and may be a one-liquid type (one-liquid type) or a two-liquid type (two-liquid type), but preferably a two-liquid type.

Silicone oil means a substance containing a viscous silicone. The composition for forming an artificial model according to an embodiment of the present invention may change the signal intensity in an image taken by CT or MRI according to the content of silicone oil. Therefore, if the content of the silicone oil is differently adjusted for each sub-structure forming the artificial model, the intensity can be adjusted for each sub-structure so as to look similar to the human body in the captured image.

In addition, in the case of the silicone oil, it is excellent in compatibility with urethane resin or silicone resin, and when an artificial model is formed, the structure can be stably maintained for a long time.

The silicone oil that can be used in the present invention may be used without particular limitation as long as it has excellent compatibility with a urethane resin or silicone resin, and may be, for example, PDMS (polydimethylsiloxane), but is not limited thereto. For a specific example, the HU (Hounsfield Unit) value in the CT image of the PDMS is about 10 to 20 HU lower than the HU value of the CT number of water. Therefore, when mixed with the base resin, the base resin having a high HU value may decrease the HU value after mixing, and vice versa. In addition, even in the case of a base resin having an MR signal of 0, MR signal generation can be induced by mixing PDMS.

In one embodiment of the present invention, the silicone oil may have a viscosity of 100 to 3000cs. In the case of the viscosity in the above range, the workability and moldability of the artificial model may be the best, and when the viscosity of the silicone oil is less than 100cs, curing of the artificial model may be difficult, and if it exceeds 3000cs, mixing of the composition is sufficient. It may not be done.

In one embodiment of the present invention, the composition for forming an artificial model body for imaging may include 60 to 90 parts by weight of the base resin and 10 to 40 parts by weight of silicone oil. In the above range, the artificial model may have excellent stiffness, and may have the best processability and formability.

When the content of the silicone oil in the composition exceeds 40 parts by weight, the homogeneity of the base resin and the silicone oil is lowered, the silicone oil is cured like water droplets, and curing may not be completely performed.

In addition, the present invention provides an artificial model for imaging, made of the composition.

The artificial model made of the composition of the present invention can be photographed in both CT and MRI equipment, and can exhibit various image signal strengths depending on the content of silicone oil.

In one embodiment of the present invention, the artificial model may include an artificial model for imaging, including a plurality of sub-structures having different silicone oil contents of the composition.

Since the image signal intensity is different depending on the content of the silicone oil, when each of a plurality of sub-structures is made of a composition having a different silicone oil content, an artificial model manufactured by combining the plurality of sub-structures is provided with each sub at the time of imaging. You can get images or photos that are clearly readable in structure.

One embodiment of a method for manufacturing an artificial model according to the present invention,

Obtaining a composition for forming an artificial model for imaging by mixing silicone oil with a base resin; Manufacturing an artificial model mold; And injecting the composition into a mold and curing it to produce an artificial model for imaging.

The composition for forming an artificial model body for imaging may be mixed by adjusting the content of silicone oil as described above, for example, when manufacturing an artificial model body having a plurality of sub-structures, a plurality corresponding to each sub-structure Compositions having different dog silicone content can be prepared.

The mold can be produced without limitation if it is a known method of manufacturing a mold. For example, a mold can be manufactured using a 3D printer, but is not limited thereto.

Curing of the base resin can be carried out by applying heat or light or standing at room temperature. In the case of using a two-part resin, one agent (the main agent) is mixed with silicone oil and injected into the mold, followed by the second agent (the curing agent. ) May be performed by adding the first agent (the main agent) and the silicone oil and the second agent (the curing agent) and injecting them into the mold. In the case of using the two-part resin, the curing time may vary depending on the specific type of base resin used, and may be, for example, 10 minutes to 20 hours, but is not limited thereto.

In an embodiment of the method for manufacturing an artificial model according to the present invention, the step of removing the bubbles introduced by pressing the composition injected into the mold; may further include.

When bubbles are present in the composition, when an image of the artificial model is obtained, an appropriate image signal for diagnosis may not be obtained.

Pressurization can be used without limitation by a known method. For example, a pressurization chamber may be used, but is not limited thereto.

In the step of removing the air bubbles, a unique curing time may be different depending on the type of the base resin, and thus the pressure can be appropriately applied in consideration of the curing time.

In addition, the present invention comprises the steps of manufacturing an artificial model for imaging with the composition; And photographing the artificial model using a computed tomography machine (CT) or a magnetic resonance imaging machine (MRI) to control the image signal intensity of the captured image by controlling the amount of silicone oil in the composition. , It provides a method of adjusting the video signal strength.

As described above, the artificial model for imaging with a plurality of sub-structures having different silicone oil contents by adjusting the content of the silicone oil of the composition is an image that is divided into sub-structures so that it can be clearly read by CT and MRI. Can get

Hereinafter, examples will be described in detail to specifically describe the present invention.

Example

1. Artificial for imaging Model Preparation of the composition (Figure 1)

(One) Example One

Urethane resin was used as the base resin, and commercially available Vytaflex 40 was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 1-1. Vytaflex 40 90 parts by weight and PDMS 10 parts by weight

Example 1-2. 80 parts by weight of Vytaflex 40 and 20 parts by weight of PDMS

Example 1-3. Vytaflex 40 70 parts by weight and PDMS 30 parts by weight

Example 1-4. 60 parts by weight of Vytaflex 40 and 40 parts by weight of PDMS

(2) Example 2

A urethane resin was used as the base resin, and a commercially available Smooth-Cast 45D was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 2-1. Smooth-Cast 45D 90 parts by weight and PDMS 10 parts by weight

Example 2-2. Smooth-Cast 45D 80 parts by weight and PDMS 20 parts by weight

Example 2-3. Smooth-Cast 45D 70 parts by weight and PDMS 30 parts by weight

Example 2-4. Smooth-Cast 45D 60 parts by weight and PDMS 40 parts by weight

Example 2-5. Smooth-Cast 45D 50 parts by weight and PDMS 50 parts by weight

(3) Example 3

A urethane resin was used as the base resin, and a commercially available Smooth-Cast 300Q was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 3-1. Smooth-Cast 300Q 90 parts by weight and PDMS 10 parts by weight

Example 3-2. Smooth-Cast 300Q 80 parts by weight and PDMS 20 parts by weight

Example 3-3. Smooth-Cast 300Q 70 parts by weight and PDMS 30 parts by weight

Example 3-4. Smooth-Cast 300Q 60 parts by weight and PDMS 40 parts by weight

(4) Example 4

A urethane resin was used as the base resin, and a commercially available Smooth-Cast 325 was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 4-1. Smooth-Cast 325 90 parts by weight and PDMS 10 parts by weight

Example 4-2. Smooth-Cast 325 80 parts by weight and PDMS 20 parts by weight

Example 4-3. Smooth-Cast 325 70 parts by weight and PDMS 30 parts by weight

Example 4-4. Smooth-Cast 325 60 parts by weight and PDMS 40 parts by weight

(5) Example 5

Urethane resin was used as the base resin, and commercially available PMC-780 Dry was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 5-1. PMC-780 Dry 90 parts by weight and PDMS 10 parts by weight

Example 5-2. PMC-780 Dry 80 parts by weight and PDMS 20 parts by weight

Example 5-3. PMC-780 Dry 70 parts by weight and PDMS 30 parts by weight

Example 5-4. PMC-780 Dry 60 parts by weight and PDMS 40 parts by weight

(6) Example 6

Urethane resin was used as the base resin, and commercially available PMC-121/30 was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 6-1. PMC-121/30 90 parts by weight and PDMS 10 parts by weight

Example 6-2. PMC-121/30 80 parts by weight and PDMS 20 parts by weight

Example 6-3. PMC-121/30 70 parts by weight and PDMS 30 parts by weight

Example 6-4. PMC-121/30 60 parts by weight and PDMS 40 parts by weight

(7) Example 7

Urethane resin was used as the base resin, and commercially available PMC-780 Wet was used. PDMS (3000 cs) was used as the silicone oil. To the subject of the urethane resin, silicone oil is mixed according to each content as follows and stirred well to be uniformly blended, and again, a curing agent is mixed with this mixture and stirred to achieve a uniform blend to obtain a composition.

Example 7-1. PMC-780 Wet 90 parts by weight and PDMS 10 parts by weight

Example 7-2. PMC-780 Wet 80 parts by weight and PDMS 20 parts by weight

Example 7-3. PMC-780 Wet 70 parts by weight and PDMS 30 parts by weight

Example 7-4. PMC-780 Wet 60 parts by weight and PDMS 40 parts by weight

2. Artificial for imaging Model Production ( Example 8)

An artificial model mold of the human head was produced using a 3D printer. At this time, the mold was divided into a plurality of sub-structures. Fig. 2 shows a photograph of the mold.

The composition having a different PDMS content for each sub-structure of the mold was introduced (bone part is Smooth-Cast 385 (silicone oil 30 parts by weight), Vytaflex 40 (PDMS is 30 parts by weight), and the skin part is smooth-cast 45D (PDMS 25 parts by weight), cylindrical pillars using Smooth-Cast 300Q (PDMS 35 parts by weight.) and standing at room temperature and cured to prepare an artificial model for imaging. 3 shows a photograph in which the composition is introduced into the mold.

At this time, before the curing of the composition, pressure was applied to the pressure chamber to remove the introduced air bubbles.

After the curing was completed, the mold was removed to obtain an artificial model. The manufactured artificial model image is shown in Fig. 6 (a).

Experimental Example

1. Each Of embodiments Measurement of change in CT number (signal intensity)

In order to measure the change in the CT number (HU) value of each embodiment, the CT imaging device used IQon Spectral CT (Philips　Healthcare, Cleveland, USA), acquires the image of the specimen, and obtains the CT signal intensity HU value. It was measured using Image J 1.51j8 program. This is shown in Figure 4. Looking at this, it was confirmed that as the PDMS content increased, the CT number value of each material also increased.

2. Each Of embodiments Relaxation time T _One , T ₂ Measure of change

In order to measure the image signal change in MRI in each embodiment, the MRI imaging device acquires MR images using MAGNETOM Avanto 1.5T MRI (Siemens, Erlangen, Germany), and changes the relaxation time T ₁ , T ₂ . It was measured through the Image J 1.51j8 program. This is shown in Figure 5a (PDMS 20 parts by weight: Example 1-2, Example 2-2, Example 3-2, Example 4-2, Example 5-2, Example 6-2, Example 7-2 ), Figure 5b (PDMS 30 parts by weight: Example 1-3, Example 2-3, Example 3-3, Example 4-3, Example 5-3, Example 6-3, Example 7- 3).

3. Comparison of curing states of compositions

Specimens of the compositions prepared according to Examples 2-2 to 2-5 were observed with an optical microscope, and the results are shown in FIG. 6 (20 X 0.403 magnification).

Referring to FIG. 6, when the content of PDMS is 40 parts by weight or less, it can be confirmed that PDMS is homogeneously mixed with the base resin, and when the content of PDMS is more than 40 parts by weight (Examples 2-5, FIG. 6) In (D)), it was confirmed that the PDMS was clogged like water droplets, and the mixing characteristics with the base resin were slightly lowered (FIG. 6).

4. Artificial Model CT and MRI imaging

The artificial model for imaging in Example 8 was taken by CT and MRI, and the photographed picture is shown in FIG. 6. Through this, various image signals could be made through the signal conditioning agent (PDMS) of the present invention, and an image that could be clearly read could be obtained. (In FIG. 7, (a) the artificial model of Example 8, (b) is a T ₁ photograph in MRI, (c) is a T ₂ photograph in MRI, and (d) is a CT photograph.)

Claims (8)

delete delete delete delete delete delete delete Preparing an artificial model for imaging with a composition for forming an artificial model for imaging including a base resin and silicone oil; And
Photographing the artificial model using a computed tomography machine (CT) or a magnetic resonance imaging machine (MRI);
Including, by adjusting the content of the silicone oil of the composition to adjust the video signal intensity of the captured image, the method of adjusting the video signal intensity.

Images