KR102124283B1 - Blockage sheet for intra-oral ventral protection - Google Patents

Abstract

The present invention relates to a blocking sheet for protecting an affected area in the oral cavity, which has adhesive force in a predetermined size, and is attached to the affected area in the oral cavity. According to the present invention, since the blocking sheet is attached to the affected area including a surgical site, a wound, and the like in the oral cavity, the recovery of the affected area can be assisted by protecting the affected area effectively.

Description

Blockage sheet for intra-oral ventral protection

The present invention relates to a barrier sheet for protecting the affected area in the oral cavity, and in more detail, as attached to the affected area including a surgical site, a wound, and the like in the oral cavity, it can effectively assist the recovery of the affected area by assisting the recovery of the affected area. It relates to a blocking sheet for protecting my affected area.

First, when a wound or surgical site occurs in the oral cavity, the affected area may be disfigured or infected from bacteria from contact with saliva, food, etc., and the affected area is effectively protected to recover the affected area in the oral cavity. Should be prevented.

Here, in order to protect the affected area in the oral cavity, a method of directly stitching a surgical site or compressing it using a removable device is used, but when sewing in a state where the gum is insufficient, the wound may burst, or when a removable device is used. There is a disadvantage that the feeling of foreign body is also large.

At this time, Korean Patent Publication No. 10-2019-0097450 (invention name: patch for treating oral wounds) has been disclosed as a prior art related to protecting the affected area in the oral cavity.

In the prior art, the patch is attached to the oral mucosa to release a drug that treats oral wounds, and the adhesive layer supports the adhesive layer, and after a period of time after the patch is attached to the oral mucosa, the drug is continuously applied to the adhesive layer. A patch for oral wound treatment is proposed, comprising a support supply layer to be supplied and a protective layer to protect the adhesive layer before use of the patch.

The prior art can be attached to the affected area in the mouth by the adhesive layer to protect the wound, but for the treatment of the affected area it is necessary to continuously release the drug for the treatment of oral wound, and for this, a support supply layer is required, which is complicated and cumbersome. There are disadvantages.

Accordingly, there is a need to develop a barrier sheet for protecting the affected area in the oral cavity, which is excellent in adhesion in a relatively simple structure and can effectively assist the recovery while effectively protecting the affected area including the surgical site and wound in the oral cavity. That is true.

The present invention has been devised to overcome the problems of the above technology, and is to provide a blocking sheet capable of assisting the recovery of the affected area by effectively protecting the affected area as being attached to the affected area including a surgical site, a wound, and the like in the oral cavity. The purpose.

Another object of the present invention is a barrier sheet that can reduce the hassle of being removed directly by being biodegraded after a certain period of time after being attached to the oral cavity including an absorbent base and absorbed and decomposed by the skin tissue in the oral cavity. Is to provide.

Another object of the present invention is to provide a barrier sheet having improved structural stability and crosslinking property by further including an auxiliary agent in the absorbent base.

Another object of the present invention is to provide a barrier sheet having excellent chemical resistance, impact resistance, and mechanical properties, including a non-absorbent base.

A further object of the present invention is to provide a barrier sheet having improved structural stability, durability, and heat resistance by including an additive in a non-absorbent base.

A further object of the present invention is to provide a barrier sheet that can be effectively adhered and attached to the affected area in the oral cavity by applying an adhesive containing mussel tuft protein to one side.

In order to achieve the above object, the barrier sheet for protecting the affected area in the oral cavity according to the present invention is characterized by being attached to the affected area in the oral cavity, having an adhesive force in a state made of a predetermined size.

In addition, the barrier sheet is characterized in that the melt index (MI) is 10 to 80g/10min at 2.16Kg of 190°C based on ASTM D1238, and the peel strength of 0.5 to 1.0N/mm at 150 to 200°C.

In addition, the barrier sheet is characterized by comprising an absorbent base comprising any one of polyglycolide, polylactic acid, polydioxanone, or mixtures thereof.

Furthermore, the absorbent base is characterized by comprising an adjuvant containing 1 to 5% by weight of ethyl cellulose (Ethyl cellulose).

According to the blocking sheet for protecting the affected area in the oral cavity according to the present invention,

1) As it is attached to the affected area including the surgical site, wound, etc. in the oral cavity, it can effectively assist the recovery of the affected area by protecting the affected area,

2) After attaching to the oral cavity, including the absorbent base, it can be biodegraded and absorbed naturally after a certain period of time, and it can be absorbed and decomposed by the skin tissue in the oral cavity, reducing the hassle of removing it directly.

3) Structural stability and crosslinking properties are improved not only by adding an auxiliary agent to the absorbent base,

4) Including non-absorbent base, chemical resistance, impact resistance, and mechanical properties can be excellent,

5) Structural stability, durability and heat resistance can be further improved by including additives in the non-absorbent base,

6) An adhesive containing mussel tuft protein is applied to one side, so that it can be effectively adhered to the affected area in the oral cavity.

1 is a conceptual diagram showing an embodiment of a blocking sheet for protecting the affected area in the oral cavity of the present invention.
Figure 2 is a flow chart showing a method for preparing the adjuvant of the present invention.
Figure 3 is a flow chart showing a method for producing the additive of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. The accompanying drawings are not drawn to scale, and the same reference numbers in each drawing refer to the same components.

1 is a conceptual diagram showing an embodiment of a blocking sheet for protecting the affected area in the oral cavity of the present invention.

The blocking sheet 10 for protecting the affected area in the oral cavity of the present invention has adhesive strength in a state of being formed in a predetermined size, and may be attached to the affected area in the oral cavity.

That is, as it is attached to the affected area including a surgical site, a wound, and the like in the oral cavity, it can effectively assist the recovery of the affected area by protecting the affected area. Unlike the method in which the blocking sheet 10 is conventionally sewed or compressed using a separate device when a surgical site and a wound occur in the oral cavity, the blocking sheet 10 is simply attached to the affected area to effectively protect the affected area, thereby providing food or It can prevent foreign substances from entering the affected area and infection. And even in the case of a wound that needs to be sewn, the upper part can be covered to protect the affected area from external stimuli.

At this time, the blocking sheet 10 for protecting the affected area in the oral cavity of the present invention may be in the form of a membrane, sheet, panel, or the like, or may be in the form of a circular, rectangular shape, such as a conventional band-aid, and the adhesion is given to the affected area in the mouth Can be glued properly. In addition, in order to reduce the feeling of heterogeneity due to the attachment of the blocking sheet 10 in the oral cavity, it is also possible to cut and use the blocking sheet 10 according to the shape and size of the affected area.

First, the barrier sheet 10 for protecting the affected area in the oral cavity of the present invention may have a peel strength of 0.5 to 1.0 N/mm at 150 to 200°C.

At this time, the peel strength (peel strength) refers to the strength to withstand peeling, and how much the adhesion target (here, the attachment target means the tongue in the mouth, the gum around the teeth, the mucous membrane in the mouth, etc.) has strong adhesion and adhesion This is a shame. Here, the adhesive surface of the affected area of the blocking sheet 10 of the present invention has the peel strength of the above-described value, and thus can be effectively prevented from falling off due to contact with saliva or tongue in the oral cavity after being attached to the affected area.

At this time, if it has a value lower than the peel strength described above, the adhesive strength in the oral cavity is too weak, and if it has a value higher than the peel strength described above, the sediment of the blocking sheet 10 will remain in the mouth when peeling the attached sheet due to too close adhesion. Since the problem that it may occur, the numerical range as described above was obtained experimentally.

In addition, the barrier sheet 10 may have a melt index (MI) and a melt index (MI) of 10 to 80 g/10min at 2.16 Kg at 190°C based on ASTM D1238.

At this time, the melt index is a flow rate when the melt is extruded from the piston under a predetermined constant condition, and is an index indicating the ease of flow of the melt, and below the melt index standard, the hardness of the barrier sheet 10 is too low and the affected area is too low. It cannot be reliably adhered and protected, and above the melt index standard, the hardness of the barrier sheet 10 becomes high and becomes hard, so it can be inconvenient to give a feeling of foreign body, and there is a disadvantage that it does not reliably adhere to the affected part. Numerical ranges were derived.

As another embodiment, the barrier sheet 10 may include an absorbent base including any one of polyglycolide, polylactic acid, and polydioxanone, or a mixture thereof. At this time, in order to improve the function of the barrier sheet 10 in addition to the above-described components, it is also possible to include a separate additive.

Here, polyglycolide is a biodegradable polymer, and is a white crystal produced by heating glycolic acid or heating sodium chloroacetate. At this time, pre-glycolide has been put into practical use as a component of a surgical bioabsorbable suture and can be hydrolyzed in vivo and discharged through the metabolic pathway into the body.

In addition, polylactic acid is extracted from renewable natural raw materials such as potato and corn starch, and is naturally decomposed into water and carbon dioxide, so it is safe and eco-friendly in vivo. In addition, it stimulates collagen production in the dermal layer of the skin and can help to create new skin tissue.

In addition, polydioxanone is a biodegradable crystalline polymer in which the ether-ester unit is repeated several times, and can be obtained by ring-opening polymerization of the monomer para-dioxanone (p-dioxanone). The polydioxanone is decomposed by hydrolysis and escapes to the urine. When decomposed, polydioxanone has a characteristic that there is almost no foreign material reaction, and thus it can be used biomedically.

At this time, when the above-mentioned materials are simultaneously included in the barrier sheet 10, it may be included in the barrier sheet 10 in the form of a copolymer having high crystallinity or simple mixing or copolymerization thereof. In addition, the absorbent base may be in the form of a film, sheet, or the like through a solidification and compression process, and may be attached in the oral cavity by additionally providing adhesion.

The blocking sheet 10 including the absorbent base can be biodegraded and absorbed naturally after a certain period of time after being attached to the oral cavity, and can be reduced by the absorption of the skin tissue in the oral cavity, thereby reducing the hassle of removing the blocking sheet 10. It has the advantage of being.

Figure 2 is a flow chart showing a method for preparing the adjuvant of the present invention.

In addition, the absorbent base can further improve the structural stability and crosslinkability of the barrier sheet 10 by further including an auxiliary agent containing ethyl cellulose, and specifically, an auxiliary agent in a ratio of 1 to 5% by weight. It can contain.

These supplements are the first material manufacturing step (S100), the second material manufacturing step (S110), the third material manufacturing step (S120), the fourth material manufacturing step (S130), the fifth material manufacturing step (S140), and the completion of the auxiliary It may be manufactured through the step (S150), the specific method is as follows.

First, the primary material production step (S100) is toluene 60 to 75% by weight, sorbitan monooleate (Sorbitan monooleate) 20 to 35% by weight, ethyl cellulose (Ethyl cellulose) 1 to 5% by weight and then mixed 50 to It is a process of preparing the primary material by stirring at a rate of 200 to 500 rpm for 40 to 80 minutes at 70°C.

Here, sorbitan monooleate is a material having excellent solubility in a lipophilic material as synthesized from fatty acid esters of sorbitan (Sorbitan) obtained by an in-molecular dehydration reaction of sorbitol (Sorbitol). This sorbitan monooleate is a yellowish viscous liquid, and is present in a liquid state at room temperature, so it has excellent emulsification and dispersion at room temperature, and is characterized by being well soluble in organic solvents such as ethanol, isopropanol, and toluene. It serves as an ionic surfactant and emulsifier.

In addition, ethyl cellulose is a cellulose derivative that converts a part of the hydroxy group of cellulose into ethyl ether, and is a substance whose properties vary depending on the degree of substitution. It is a white solid with no odor, which is not soluble in water, but is characterized by being soluble in many organic solvents and increasing viscosity. It serves as a thickener. Finally, toluene serves as a solvent for dissolving sorbitan monooleate and ethyl cellulose.

These sorbitan monooleates and ethylcellulose can help maintain the stability of the polymerization reaction of acrylic acid, which will be described later, and can help to prepare an auxiliary having structurally uniform and stable particles by improving the dispersing power of acrylic acid. have.

Next, the secondary material manufacturing step (S110) is 70 to 85% by weight of the primary material, 10 to 25% by weight of acrylic acid (Acrylic acid), 1 to 5% by weight of MBA (N,N'-methylenebisacrylamide) after mixing 30 It is a process of preparing a secondary material by stirring at a rate of 200 to 500 rpm for 100 minutes. Here, acrylic acid is a simplest unsaturated carboxylic acid containing a carboxylic acid and a vinyl group as a monomer for preparing an auxiliary agent, and is highly soluble, so it is easily soluble in various solvents such as water, alcohol, and benzene. In addition, MBA serves as an initiator for initiating the polymerization process of acrylic acid, which is a monomer, through which acrylic acid can be polymerized.

Then, the tertiary material production step (S120) is a secondary material 85 to 95% by weight, 5 to 15% by weight of sodium hydroxide solution is mixed at 5 to 10 ℃ and stirred at a rate of 15,000 to 20,000rpm to tertiary material It is a manufacturing process. Here, the sodium hydroxide solution is preferably 7 to 8N (normal concentration, g equivalent number of solute dissolved in 1 L of the solution), it was added to neutralize the acrylic acid in the solution.

Next, in the fourth material production step (S130), 90 to 99% by weight of the tertiary material and 1 to 10% by weight of the initiator are mixed and heated at 60 to 80° C. for 1 to 3 hours under a nitrogen atmosphere to prepare a quaternary material. It is a process.

Here, 2,2'-azobis(2-amidinopropane) dihydrochloride (2,2'-Azobis(2-methyl-propionamidine) dihydrochloride) may be used as the initiator, and the acrylic acid polymerization reaction is substantially initiated. Plays a role. At this time, nitrogen gas was injected to remove impurities and moisture in the reaction tank.

Subsequently, the fifth material preparation step (S140) is a process of preparing a fifth material by mixing 90 to 95% by weight of methanol and 5 to 10% by weight of the fourth material, and the supplementary completion step (S150) filters the fifth material After obtaining the precipitate and drying the precipitate at 30 to 50 ℃ for 20 to 30 hours to complete the adjuvant.

Here, a precipitate is generated by mixing an excess of methanol and a quaternary material, and the precipitate can be obtained and dried through a filtration process to complete a white powder-like auxiliary agent.

The adjuvant prepared through this process has high absorbency and structurally stable characteristics, and may be added to the absorbent base to help improve the crosslinkability and structural stability of the barrier sheet 10.

In another embodiment, the barrier sheet 10 includes a non-absorbent base including any one of polytetrafluoroethylene, polyvinylidene fluoride, and polyetheretherketone, or a mixture thereof. can do. At this time, in order to improve the function of the barrier sheet 10 in addition to the above-described components, it is also possible to include a separate additive.

First, polytetrafluoroethylene is a non-flammable fluorine resin belonging to an organic polymer series, consisting of large molecules made by chemically bonding many small molecules (units) in chains or nets. It has high heat and chemical resistance, and has a low coefficient of friction. There are features. In addition, polyvinylidene fluoride is a thermoplastic fluorine polymer, which has excellent chemical resistance and a high melting point of 171ㅀC, and is a material exhibiting excellent mechanical properties unlike other fluorine resins. In addition, polyetheretherketone is a thermoplastic resin with particularly excellent heat resistance, and is a material having characteristics that are easy to mold and process, and have excellent chemical resistance, impact resistance, and colorability compared to polyimide.

As described above, when the above-described materials are included in the barrier sheet 10 at the same time, it may be included in the barrier sheet 10 in the form of a copolymer having high crystallinity or a simple mixing or copolymerization thereof, and the membrane may be subjected to a solidification and compression process, etc. The blocking sheet 10 may be completed in the form of a sheet or the like.

Figure 3 is a flow chart showing a method for producing the additive of the present invention.

In addition, the non-absorbent base may include zinc oxide (Zinc Oxide) additives to improve the structural stability of the barrier sheet 10, and at the same time improve durability and heat resistance, specifically 1 to 5% by weight of the Additives may be included.

These additives may be prepared through an initial material production step (S200), an intermediate material production step (S210), a heating step (S220), and an additive completion step (S230), and the specific manufacturing method is as follows.

First, the initial material preparation step (S200) is paraffin oil 45 to 60% by weight, phosphite complex (Phosphite Complex) 5 to 20% by weight, oleic acid (oleic acid) 1 to 10% by weight, benzoic acid (Benzoic Acid) 0.1 to 1 It is a process to prepare the initial material by mixing 5% to 20% by weight of barium hydroxide, barium hydroxide, and 0.5 to 5% by weight of zinc oxide.

Here, barium hydroxide may improve heat resistance, and zinc oxide may help to preserve the storage and functional stability of the non-absorbent base by performing a role of preventing phenomena such as coloring, material deformation, and functional degradation. Here, paraffin oil serves as a solvent for the production of the additive, and oleic acid can improve the activity of the additive. In addition, the phosphite complex and benzoic acid may help to further improve the function and storage stability of the additives and non-absorbent bases by playing a role in supporting the functions of zinc oxide described above.

Thereafter, the intermediate material production step (S210) is a process of preparing an intermediate material by mixing 75 to 85% by weight of the initial material and 15 to 25% by weight of auxiliary fibers including polypropylene.

At this time, the auxiliary fiber is made of polypropylene, which can further improve the durability and durability of the barrier sheet 10, and has antimicrobial properties, so it can adhere to the oral cavity and help prevent bacterial infection. The specific method for manufacturing such an auxiliary fiber will be described later.

Next, the heating step (S220) is a process of heating the intermediate material at 100 to 150° C. for 10 to 30 minutes, and the additive completion step (S230) is a process of filtering the heated intermediate material to obtain a residual additive.

At this time, the materials of the above-described intermediate material may be polymerized through the superheat process, and the additive may be completed by removing the condensate generated through the reaction through a filtration process.

The additives manufactured through these processes can be stored in a stable state without deterioration by improving the heat resistance and durability of the barrier sheet 10 of the present invention, and can be attached to the affected area in the oral cavity to assist in functioning stably.

Furthermore, the above-described auxiliary fiber may be manufactured through a first material manufacturing step, a second material manufacturing step, a third material manufacturing step, a fourth material manufacturing step, and an auxiliary fiber completion step.

First, the first material preparation step is 60 to 80% by weight of one of distilled water and methanol, 10 to 20% by weight of polypropylene, 5 to 15% by weight of 1-vinyl imidazole, This is a process of preparing the first material by mixing 0.1 to 5% by weight of benzophenone (BP).

Here, polypropylene is a matrix polymer fiber that performs an antibacterial function, and is preferably used after washing several times before use and drying at 50 to 70°C. In addition, 1-vinyl imidazole is generally used as a resin curing agent and a polymer monomer, and serves as a monomer for auxiliary fiber polymerization in this process, and is polymerized on the surface of polypropylene. In addition, benzophenone serves as a photoinitiator for polymerization.

Next, the second material manufacturing step is a process of preparing the second material by irradiating the first material with ultraviolet light for 20 to 500 minutes in a nitrogen atmosphere and a temperature condition of 50 to 80°C, wherein the above-mentioned components are polymerized through ultraviolet irradiation It is a process. At this time, it is preferable to maintain a distance of 10 cm between the first material and the light source during ultraviolet irradiation.

Thereafter, the third material manufacturing step is a process of preparing the third material by performing Soxhlet extraction of the second material using methanol for 1 to 5 hours and drying at 50 to 70°C. Here, Soxhlet extraction is an extraction method using an organic solvent, and evaporation of the solvent extracts lipids from the sample, and is performed to remove unreacted monomers and other by-products in the second substance.

Next, the fourth material preparation step is 5 to 20% by weight of the third material, intermediate reagents 80 to 95% by weight of any one or more mixtures of methyl iodide, ethyl iodide, butyl iodide, and isobutyliodine. % Is the process of preparing the fourth material by mixing for 3 to 6 hours.

Here, the intermediate reagent is a reagent for initiating the quaternization of the polymerized material through ultraviolet irradiation, and the quaternization of the polymerized material may proceed through this process, thereby improving the antibacterial effect of the auxiliary fiber.

Finally, the auxiliary fiber completion step is a process of completing the auxiliary fiber by washing the fourth material with methanol and water 3 to 10 times and drying at 40 to 80°C.

The auxiliary fiber produced through this process has better antimicrobial properties than the existing polypropylene fiber and is contained in the blocking sheet 10, which may help to reduce the incidence of bacterial infection in the affected area and improve the structural stability and durability of the blocking sheet 10. It can be improved to help protect the affected area more effectively.

As another embodiment, an adhesive containing mussel tuft protein may be applied to one surface of the barrier sheet 10. At this time, the adhesive has an adhesive and an adhesive component and may help to adhere and adhere to the affected area in the oral cavity. In addition, in order to improve the function of the adhesive, it is also possible to separately include other additives in addition to mussel tug protein.

Here, the mussel family protein consists of 12 or more types of proteins with a flat pad attached to the end of a thin thread called a byssus. At this time, there are high proportions of the proteins named Mfp-1 (Mytilus foot protein-1), Mfp-3, and Mfp-5 in the mussel family protein, and 3,4-dihydroxyphenyl-L-alanine (DOPA) in these proteins. ) Is very rich in modified amino acids.

The mussel tuft protein has a strong coating ability and adhesion, and in particular has excellent adhesive properties in water, and because it is a protein component, it has high functionality as a mucoadhesive agent and hemostatic agent.
As described so far, although the blocking sheet for protecting the affected area in the oral cavity according to the present invention is expressed in the above description and drawings, it is merely for example and the spirit of the present invention is not limited to the above description and drawings, and the present invention Of course, various changes and changes are possible without departing from the technical idea of.

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10: barrier sheet S100: primary material manufacturing step
S110: Secondary substance production step S120: Thirdary substance production step
S130: 4th material production step S140: 5th material production step
S150: adjuvant completion step S200: initial material manufacturing step
S210: intermediate material production step S220: heating step
S230: additive completion step

Claims (12)

It is attached to the affected area in the oral cavity with adhesive strength in a state made of a predetermined size,
Polytetrafluoroethylene (Polytetrafluoroethylene), polyvinylidene fluoride (polyvinylidene fluoride), polyetheretherketone (Polyetheretherketone), or a non-absorbent base containing a mixture thereof, and
The non-absorbent base,
A barrier sheet, characterized in that it contains 1 to 5% by weight of an additive containing zinc oxide (Zinc Oxide). It is attached to the affected area in the oral cavity with adhesive strength in a state made of a predetermined size,
Polyglycolide (polyglycolide), polylactic acid (Polylactic acid), polydioxanone (Polydioxanone) any one or a mixture containing an absorbent base comprising a mixture thereof,
The absorbent base,
Contains 1 to 5% by weight of an auxiliary agent containing ethyl cellulose (Ethyl cellulose),
The adjuvant,
After mixing 60 to 75% by weight of toluene, 20 to 35% by weight of sorbitan monooleate, and 1 to 5% by weight of ethyl cellulose, 200 to 500 rpm for 40 to 80 minutes at 50 to 70°C Preparing the primary material by stirring at the rate of the primary material production step;
After mixing the primary material 70 to 85% by weight, acrylic acid (10 to 25% by weight), MBA (N,N'-methylenebisacrylamide) 1 to 5% by weight at a rate of 200 to 500rpm for 30 to 100 minutes Preparing a secondary material by stirring, a secondary material manufacturing step;
A step of preparing a tertiary material by mixing the secondary material 85 to 95% by weight and 5 to 15% by weight of sodium hydroxide solution at 5 to 10° C. and then stirring at a rate of 15,000 to 20,000 rpm;
A step of preparing a quaternary material by mixing 90 to 99% by weight of the tertiary material and 1 to 10% by weight of an initiator and heating it at 60 to 80° C. for 1 to 3 hours under a nitrogen atmosphere;
Mixing 90 to 95% by weight of methanol and 5 to 10% by weight of the fourth material to prepare a fifth material, a fifth material production step;
Filtering the fifth material and obtaining a precipitate, and then drying the precipitate at 30 to 50° C. for 20 to 30 hours to complete an auxiliary agent. The method according to claim 1 or 2,
The blocking sheet,
The melt index (MI) is 10 to 80 g/10min at 2.16 Kg at 190°C based on ASTM D1238, and the peel strength at 150 to 200°C is 0.5 to 1.0 N/mm, the barrier sheet. According to claim 1,
The additive,
45 to 60% by weight of paraffin oil, 5 to 20% by weight of Phosphite Complex, 1 to 10% by weight of oleic acid, 0.1 to 1% by weight of Benzoic Acid, Barium Hydroxide 5 To 20% by weight, zinc oxide (Zinc Oxide) 0.5 to 5% by weight to prepare the initial material, the initial material production step;
Preparing an intermediate material by mixing the initial material 75 to 85% by weight and 15 to 25% by weight of an auxiliary fiber including polypropylene;
Heating the intermediate material at 100 to 150° C. for 10 to 30 minutes;
Filtering the heated intermediate material to obtain an additive that is a residue, the additive completion step; characterized in that produced through, the barrier sheet. The method of claim 4,
The auxiliary fiber,
One of distilled water and methanol, 60 to 80% by weight, polypropylene (10 to 20% by weight), 1-vinyl imidazole (1-Vinyl imidazole), 5 to 15% by weight, benzophenone (BP) 0.1 to 5 Preparing a first material by mixing weight percent, a first material preparation step;
Preparing a second material by irradiating the first material with ultraviolet light for 20 to 500 minutes under a nitrogen atmosphere and temperature conditions of 50 to 80°C;
A third material preparation step in which the second material is subjected to Soxhlet extraction for 1 to 5 hours using methanol and then dried at 50 to 70° C. to produce a third material;
5 to 20% by weight of the third substance, 80 to 95% by weight of the intermediate reagent, which is a mixture of any one or two or more of methyl iodide, ethyl iodide, butyl iodide, and isobutyl iodine for 3 to 6 hours Mixing to produce a fourth material, a fourth material manufacturing step;
Washing the fourth material with methanol and water 3 to 10 times, and then drying at 40 to 80° C. to complete the auxiliary fiber. The method according to claim 1 or 2,
The blocking sheet,
Barrier sheet, characterized in that an adhesive containing mussel tug protein is applied to one side. delete delete delete delete delete delete

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