KR102098168B1 - 3-color complex lamp toothbrush for alleviating or preventing periodontal desease - Google Patents

Abstract

The three-color composite electric toothbrush for improving and preventing periodontal disease according to the present invention is disposed on the head casing of the toothbrush, but is provided with a detachable toothbrush head; A first light source unit having different wavelengths, a second light source unit and a third light source unit are combined and combined with each other to irradiate a constructive interference wavelength of a light output density of a predetermined size or higher; And an excitation member coupled to the light irradiation module to excite the bristles.
The three-color composite electric toothbrush for improving and preventing periodontal disease according to the present invention is prevented from being cytotoxic by using the wavelengths of the visible light region irradiated by the first, second and third light source units, thereby preventing the toxicity applied to normal cells. It can be minimized, and three types of light sources can be arranged in a square shape to generate a reinforcing interference wavelength, so it can help to eradicate or prevent various oral bacteria by securing a light output density of more than a preset size.

Description

3-color combination electric toothbrush for improvement and prevention of periodontal disease {3-COLOR COMPLEX LAMP TOOTHBRUSH FOR ALLEVIATING OR PREVENTING PERIODONTAL DESEASE}

The present invention relates to a three-color composite electric toothbrush for improving and preventing periodontal disease, and more specifically, three wavelengths of three wavelengths for improving and preventing periodontal disease, which can secure optical power density by combining wavelengths of three visible light bands. It relates to a composite electric toothbrush.

As the elderly population increases worldwide, interest in medical devices and home health devices is increasing. In particular, interest and demand for dental health, which can be referred to as oral health, is increasing day by day, and interest and demand for oral products such as electric toothbrushes, dental floss, and toothpaste are increasing worldwide due to aging, well-being trends, etc. Is becoming.

One of the most important problems in dental health is the management of oral bacteria. Oral bacteria form plaque (plaque, plaque), which causes not only gum tissue, but also bacterial infection or calculus that damages bones, and eventually develops into gingivitis (smelling) or periodontitis.

Therefore, in order to manage the teeth hygienically, it is most important to remove oral bacteria, which is the root cause of plaque and plaque formation, and in the past, chemical management through various anti-inflammatory or anti-bacterial agents has been the main method. For example, it has been common to wash with mouthwash such as gargle liquid used after brushing teeth or various mouthwashes.

Recently, oral care devices using a light source of a constant wavelength band (such as a toothbrush having an ultraviolet wavelength) have been developed. For example, many methods and devices for inhibiting bacteria using ultraviolet light having a wavelength of 200 to 400 nm have been proposed.

However, in the case of such an electric toothbrush in the ultraviolet wavelength range, there is a problem in that oral side effects such as oral bacteria are eradicated due to side effects of ultraviolet rays and toxicity is applied to normal normal cells.

In addition, even in the case of oral products having a wavelength band in the visible light region, when at least one light source is combined, interference occurs between the light sources, and the overall light output density is low, which prevents various oral bacteria from being eradicated or prevented. have.

The present invention has been proposed to solve the above problems, and by using the wavelengths of the visible light region irradiated by the first, second and third light sources, cytotoxicity is prevented beforehand, so that toxicity applied to normal cells can be minimized. It can improve the prevention of periodontal disease, which can help eradicate or prevent various oral bacteria by securing the light output density of more than a preset size by arranging 3 types of light sources in a square shape to generate a reinforcing interference wavelength. Provides a 3-color composite electric toothbrush.

The three-color composite electric toothbrush for periodontal disease improvement and prevention according to the present invention for achieving the above object is disposed on the head casing of the toothbrush, the toothbrush head portion is provided detachably; A light irradiation module disposed adjacent to the brush head, and irradiating a reinforcing interference wavelength having a light output density of a predetermined size or more by combining and combining a first light source unit, a second light source unit, and a third light source unit having different wavelengths; And an excitation member coupled to the light irradiation module to excite the bristles.

The bristle portion, the bristles are arranged side by side in two rows on the central area of the plate surface of the head casing, coupled to the support plate; And while receiving the support plate may include a connecting body that is detachably coupled to the head casing.

The first light source unit, the second light source unit and the third light source unit may be provided in the head casing at a position adjacent to the support plate so that the light source of the light irradiation module does not interfere.

The light irradiation module further includes a PCB board that is electrically connected to the first, second, and third light source parts, and the first light source part is a pair of upper and lower left and right views when viewed from the front of the bristle part. The first LED light source element, and the second light source portion may be a second LED light source element provided at the lower left of the bristle portion, and the third light source portion may be a third LED light source element provided at the lower right of the bristle portion.

The first LED light source element has a wavelength band of 430 nm to 485 nm for irradiating blue light, and the second LED light source element has a wavelength band of 630 nm to 680 nm for irradiating red light, and the third LED light source element The color temperature may be 5000k to 8000k to irradiate white light.

The head casing is provided with a plurality of stepped grooves provided to be stepped inward, and a multi-level locking inclined surface for locking and unlocking the brush head portion is formed in the stepped groove in the connecting body, and the step corresponding to the locking inclined surface The groove portion may be an inclined surface corresponding surface.

The locking inclined surface and the inclined surface corresponding surface may be provided to taper to one side toward the thickness direction of the head casing from the outer surface.

The excitation member may be an ultrasonic ceramic piezoelectric element that excites the bristle part during the cleaning operation of the bristle part.

The three-color composite electric toothbrush for improving and preventing periodontal disease according to the present invention is prevented from being cytotoxic by using the wavelengths of the visible light region irradiated by the first, second and third light source units, thereby preventing the toxicity applied to normal cells. It can be minimized, and three types of light sources can be arranged in a square shape to generate a reinforcing interference wavelength, so it can help to eradicate or prevent various oral bacteria by securing a light output density of more than a preset size.

1 is a perspective view of a three-color composite electric toothbrush and charger for improving and preventing periodontal disease according to an embodiment of the present invention.
Figure 2 is a front view of the brush head portion of the tricolor composite electric toothbrush for the improvement and prevention of periodontal disease according to an embodiment of the present invention.
3 is a side view of the head casing portion including the bristles in FIG. 1.
4 is a top cross-sectional view of the bristle portion in FIG. 1.

Hereinafter with reference to the accompanying drawings will be described in detail an embodiment of a three-color composite electric toothbrush for improving and preventing periodontal disease according to the present invention.

Prior to the description, the present invention is a medical device or medical auxiliary device for improving and preventing periodontal diseases such as gingivitis.

1 is a perspective view of a three-color composite electric toothbrush for improving and preventing periodontal disease according to an embodiment of the present invention, and FIG. 2 is a brush head of a three-color composite electric toothbrush for improving and preventing periodontal disease according to an embodiment of the present invention It is a front view of a part, FIG. 3 is a side view of the head casing part including a bristle part in FIG. 1, and FIG. 4 is an upper sectional view of a bristle part in FIG.

The three-color composite electric toothbrush for improving and preventing periodontal disease according to an embodiment of the present invention is disposed on the toothbrush body 100 and the head casing 200 as shown in FIGS. A provided bristle part 220; The first light source unit 310 having different wavelengths, the second light source unit 320 and the third light source unit 330 are combined and combined with each other to irradiate a light irradiation module 300 for irradiating the reinforcing interference wavelength of a light output density equal to or greater than a preset size. ); And an excitation member 400 coupled to the light irradiation module 300 to excite the bristles 220.

The toothbrush body part 100 refers to the body casing 110 which is the rest except the head casing 200. The body casing 110 is provided mainly with a power switch 120 for turning on / off the light irradiation module 300 and an excitation button 130 to operate with the ultrasonic ceramic piezoelectric element 410 as shown in FIG. 1. Can be.

Inside the toothbrush body 100, a power supply unit (not shown, a charging battery) and a power supply line (not shown) for supplying electric power to the light irradiation module 300 and the ultrasonic ceramic piezoelectric element 410 may be provided. have.

A charging cradle 140 that is separately provided may be provided at the bottom of the toothbrush body 100. Electricity may be supplied to the power supply through the charging cradle 140.

The head casing 200 may be connected to one end of the toothbrush body 100, and the head casing 200 may be provided in a streamlined shape as a whole. A brush head portion 220 may be provided on one surface of the head casing 200.

The bristles 220 are mainly arranged side by side in two rows on the central area of the plate surface of the head casing 200, as shown in FIGS. 1 to 4, bristles coupled to the support plate 222 ( 221); And a connecting body 223 that is detachably coupled to the head casing 200 while receiving the support plate 222.

The bristles 221 may constitute a plurality of rows (arrays) along the longitudinal direction, and in this embodiment, as shown mainly in FIG. 2, two toothbrush arrays may be configured. Each array of brush heads 221 may be coupled to a support plate 222. Meanwhile, in the present embodiment, two toothbrush arrays are configured, but three toothbrush arrays may also be configured. In this case, it may be changeable in order to secure various clinical trial data. For example, it may be configured as a 2-line array for a periodontal disease patient and a 3-line array for a general public. Separately, the number of arrays may be changed according to a user's preference or in consideration of design.

The connecting body 223 may be provided detachably to the head casing 200. To this end, referring mainly to FIGS. 3 and 4, the head casing 200 is provided with a plurality of step grooves 210 to be stepped inward, and the support plate 222 corresponds to the step grooves 210. The multi-stage locking inclined surface 223 may be provided.

That is, the locking inclined surface 223 may be provided at each end of the support plate 222 and tapered toward the inside to be detachably coupled to the stepped groove 210. Here, the stepped groove portion 210 may be a tapered inclined surface corresponding surface 210 corresponding to the locking inclined surface 223.

The locking inclined surface 223 and the inclined surface corresponding surface may be provided to taper to one side toward the thickness direction of the head casing 200 from the outer surface.

Through this, the support plate 222 may be fitted to the head casing 200. That is, it is possible to prevent the penetration of water into the head casing 200 and to have a perfect waterproof function. On the other hand, as the electric toothbrush is used for a certain period of time, the support plate 222 may be detachable when the life of the bristles 221 is reached, and maintenance may be possible, such as replacing and replacing the new brush head portion 220. .

On the other hand, it is necessary to provide a light irradiation module 300 of the visible light region so that the cytotoxicity can be prevented by using the wavelength of the visible light region band to minimize the toxicity to normal cells. In addition, the light irradiation module 300 must be capable of irradiating a light output density of a predetermined size or more to help eradicate or prevent various oral bacteria. To this end, in the present invention, each light source module 310, 320, 330 of the light irradiation module 300 is provided in a square type, but the light irradiation module 300 in which three wavelengths can be reinforced (that is, three-color composite) is provided. Can be prepared.

Referring to FIGS. 2 to 4, the light irradiation module 300 mainly includes a first light source part 310, a second light source part 320 and a third light source part 330 provided to be partially exposed to the head casing 200. , It may include a PCB board 340 that is electrically connected.

The first light source unit 310, the second light source unit 320 and the third light source unit 330, the head casing in a position adjacent to the connecting body 223, so that the light source of the light irradiation module 300 does not interfere It may be provided on the (200).

In particular, the first, second, and third light source units 310, 320, and 330 may be provided in a so-called square type with the bristles 220 at the center and disposed at each corner.

Here, the first light source unit 310 is a pair of first LED light source elements 311 provided at upper left and right sides based on FIG. 2, and the second light source unit 320 is the bristle part 220 ) Is a second LED light source element (not shown) provided at the bottom left, and the third light source unit 330 may be a third LED light source element 331 provided at the bottom right of the bristle part 220.

In addition, the first LED light source element 311 has a wavelength band of 430 nm to 485 nm irradiating blue light (B), and the second LED light source element has a wavelength band of 630 nm to irradiate red light (R). In 680 nm, the third LED light source element 331 may have a color temperature of 5000k to 8000k to irradiate white light (W).

The three types of visible light, in particular, the first, second and third LED light source elements 311 and 331 may be combined to secure a light output density of a predetermined size or more. In this embodiment, the preset light output density through the first, second, and third LED light source elements 311 and 331 may be provided at approximately 180 to 240 mW (10% error range), and this light output density Experimental results through will be described later.

Meanwhile, the first, second, and third light source units 310, 320, and 330 in this embodiment are provided with three types of first, second, and third LED light source elements 311, 331, and each LED. The light sources of the first, second and third light source units 310, 320, and 330 are combined and combined to emit white light as monochromatic light through the number and arrangement of light source elements, or for the purpose of increasing the intensity of light output density or For the purpose of tuning the wavelength of the composite light, the color, number, and arrangement relationship (eg, arrangement interval, arrangement order, etc.) of each LED light source element may be set differently.

Referring to FIGS. 3 and 4, the excitation member 400 may be disposed to be interviewed on the PCB board 340. The excitation member 400 may be an ultrasonic ceramic piezoelectric element 410 that excites the bristles 220. Through the ultrasonic ceramic piezoelectric element 410, the brush head 221 can be easily washed by having the brush head 220 as needed.

Through this configuration, by using the wavelengths of the visible light region of the first, second and third light source units 310, 320, and 330, cytotoxicity is prevented beforehand, and side effects on normal cells can be minimized. .

In addition, three types of light sources may be combined with a reinforcing interference wavelength to secure a light output density of a predetermined size or more, which may help eradicate or prevent various oral bacteria.

Hereinafter, a clinical test case of a composite beam for bacteria causing gum disease through a three-wavelength, three-color composite electric toothbrush for improving and preventing periodontal disease according to an embodiment of the present invention will be described in detail.

0. Subject

■ As a prototype of a composite LED light, as shown in Table 1, in relation to the arrangement of the light irradiation module 300, in particular, the first, second and third light source units 310, 320, 330, three types were provided.

■ Type A was prepared in the same way as the embodiment of the present invention, and type B was the first light source part at the top and bottom corners, respectively, in the arrangement in which the first, second, and third light source parts were tilted 90 degrees from the A type, and the left edge Is a second light source part, the right side is a type arranged as a third light source part, and the C type is a type A and the first light source part is arranged in a square type or in the upper left and lower right corners as in the arrangement of the first, second, and third light sources, and the right side. It is a state in which the second light source part is disposed at the top and the third light source part is disposed at the bottom left.

Composite LED light standard and specification Type A B type C type

<Experiment for evaluating antibacterial activity of compound light against bacteria causing gum disease>

1.1 Purpose

As described above, the first, second, and third light source units 310, 320, and 330 of the present invention are sequentially arranged in two blue, one red, and one white, but the arrangement relationship is A, B, and C. As the light source is changed by changing, it is irradiated with an improved light output density of up to about 240 mW, and two bacteria that cause gum disease ( Porphyromonas Antibacterial activity was evaluated for gingivalis (ATCC 33277) and Aggregatibacter actinomycetemcomitans (ATCC 33384).

1.2 Experimental method

Experimental strains used to evaluate the antimicrobial activity of complex LED rays include two types of bacteria that cause gum disease ( Porphyromonas gingivalis (ATCC 33277) and Aggregatibacter actinomycetemcomitans (ATCC 33384)). Purchased and used from the American Type Culture Collection (ATCC)

Porphyromonas gingivalis (P. gingivalis) is a strain cultured in an Anaerobic bottle by replacing it with an Anaerobic gas mixture (80% N ₂ -10% Co2-10% H ₂ ) in Tryptic Soy Broth medium containing vitamin K1 solution and Hemin solution. Is counted using a microscope

After dispensing P. gingivalis at a concentration of 10 ⁴ ~ 10 ⁵ CFU / mL using 24-well in an anaerobic chamber, irradiate the complex LED rays (A, B, and C types) hourly (0 seconds, 30 seconds) , 60 seconds, 120 seconds, 180 seconds)

After irradiating the composite LED light by hour, the diluted strain is dispensed into a solid medium, and cultured for 5-7 days under anaerobic conditions (80% N ₂ -10% Co2-10% H ₂ ) at 37 ° C, followed by irradiation of the composite LED light Antibacterial activity against gum disease bacteria according to

Aggregatibacter actinomycetemcomitans (A.actinomycetemcomitans) strains cultured in BHI (Brain Heart Infusion) Broth medium were measured by using a spectrophotometer to measure the turbidity of the bacterial suspension at 660 nm and using the standard curve to measure the number of bacteria.

■ A. After dispensing actinomycetemcomitans at a concentration of 10 ⁴ ~ 10 ⁵ CFU / mL per 24-well plate, irradiate the composite LED light hourly (0 sec, 30 sec, 60 sec, 120 sec, 180 sec)

After irradiating the complex LED light by hour, the diluted strain is dispensed into a solid medium, incubated for 1 to 3 days under the condition that 34 ° C, 5% CO ₂ is supplied, and the antibacterial activity against gingival disease bacteria according to the complex LED light irradiation Evaluate

■ Evaluation of antimicrobial activity against complex LED rays (A, B, and C type) to select the optimal distribution conditions for gum disease

1.3 Experimental results

■ In this experiment, the number of bacteria of P. gingivalis was measured according to the irradiation time of A, B, and C type composite LEDs, and the antibacterial activity was evaluated. The results are shown in Table 2.

CFU / mL (X10 ⁴ ) of P. gingivalis by LED irradiation time Sample Irradiation Time (sec.) CFU / mL (× 10 ⁴ ) (Mean ± SDl) A 0 5.75 ± 0.99 30 6.57 ± 2.27 60 5.80 ± 0.72 120 6.00 ± 0.60 180 4.80 ± 0.87 B 0 5.75 ± 0.99 30 6.30 ± 2.72 60 7.03 ± 1.93 120 8.33 ± 0.95 180 7.87 ± 1.70 C 0 5.75 ± 0.99 30 6.60 ± 0.40 60 6.00 ± 0.87 120 5.93 ± 2.30 180 6.10 ± 1.76

■ Compared to the untreated group that did not irradiate light, the A type decreased by 16.5% from 180 seconds, and the B type showed a tendency to increase bacteria in proportion to the composite LED light irradiation time, and the C type did not Higher or similar tendency than treatment group

■ A. Actinomycetemcomitans antimicrobial evaluation according to the composite LED light (A, B and C) irradiation resulted in a decrease of 48.6% from 180 seconds in the case of type A compared to the untreated group, and an increase in bacteria in type B in 180 seconds. Type C reduced by 8.6% (Table 3)

CFU / mL (× 10 ⁴ ) of A. actinomycetemcomitans by LED irradiation time Sample Irradiation Time (sec.) CFU / mL (× 10 ⁴ ) (Mean ± SDl) A 0 0.35 ± 0.05 30 0.04 ± 0.06 60 0.41 ± 0.10 120 0.37 ± 0.10 180 0.18 ± 0.14 B 0 0.35 ± 0.05 30 0.12 ± 0.06 60 0.28 ± 0.00 120 0.53 ± 0.10 180 0.37 ± 0.13 C 0 0.35 ± 0.05 30 0.13 ± 0.01 60 0.30 ± 0.11 120 0.33 ± 0.01 180 0.32 ± 0.14

As a result of the first antimicrobial evaluation test, it was confirmed that the composite LED light type B had no antimicrobial effect, and the results of this experiment showed that P. gingivalis and A. actinomycetemcomitans were of type A for both strains . When the composite LED light was irradiated for 180 seconds, it showed the highest antibacterial effect and showed a better effect compared to the C type treated at the same time.

<Cytotoxicity test on gingival fibroblasts [Human gingivalis fibroblast cell]>

2.1 Purpose of the experiment

After subjecting the human gum-derived epithelial cells (HGF-1 Cell, root fibroblasts) to complex LED light irradiation by condition (array, light quantity, time), the degree of cytotoxicity (% survival) was evaluated by MTT assay.

2.2 Experimental Method

HGF-1 cells were cultured under conditions of supplying 37% temperature and 5% CO ₂ using Dulbeco's modified eagle's medium (DMEM) with medium containing 10% FBS and 1% penicillin / streptomycin.

■ The degree of cytotoxicity (% survival rate) for complex LED light irradiation is measured by the MTT [3- (4,5-dimethylthiazole-2-yl) -2,5-diphenyl-tetrazolium bromide] method.

After dividing HGF-1 cells in a 24-well plate at a concentration of 1 ㅧ 10 ⁵ cells / mL and incubating them at 37 ° C and 5% CO ₂ , the complex LED rays (A, B, and C types) are irradiated hourly ( 0 second, 30 second, 60 second, 120 second, 180 second). After irradiation, after incubation for 24 hours, 100 μL of MTT reagent was added and further reacted for 4 hours, the medium was removed and the formed formazan was dissolved with 1 mL dimethyl sulfoxide (DMSO), and absorbance was measured at 570 nm.

■ Cytotoxicity for complex LED light irradiation time is evaluated by calculating the relative cell viability based on the absorbance value of cells that have not been irradiated with complex LED light.

To evaluate the cytotoxicity of the complex LED light (A, B and C type) under all conditions in order to select the light distribution arrangement for optimal gum disease effect

2.3 Experimental results

■ Results are as shown in Table 4 and A, B and C types Cytotoxicity was not confirmed under the conditions of irradiation of the composite LED light.

The effect of LED light on the cell viability Sample Irradiation Time (sec.) Cell viability (%) A 0 100.00 ± 3.45 30 99.78 ± 3.97 60 98.50 ± 3.33 120 98.29 ± 3.69 180 98.08 ± 4.07 B 0 100.00 ± 3.45 30 99.47 ± 4.06 60 98.08 ± 3.51 120 97.44 ± 3.11 180 97.83 ± 4.02 C 0 100.00 ± 3.45 30 99.99 ± 4.21 60 99.07 ± 4.42 120 98.69 ± 3.03 180 98.55 ± 2.35

<Experiment for anti-inflammatory evaluation of compound light against bacteria causing gum disease>

3.1 Purpose of the experiment

■ This experiment is part of the evaluation of the effect of improving gum disease on irradiated complex LED light, and the degree of anti-inflammation according to the measurement of cytokine content by irradiated complex LED light on gingival fibroblasts induced inflammatory response through LPS (producing inflammation factor) Inhibition level, percentage inhibition) was evaluated.

3.2 Experimental method

■ Anti-inflammatory effect on inflammation, which is a cause of exacerbation of gum disease following irradiation of complex LED rays, is IL-6, IL-1β, IL-8 and TNF released from inflammation-induced gingival fibroblast (HGF-1) -Confirm by measuring inflammatory cytokine content such as α

Evaluation of the level of inhibition (inhibition rate%) of inflammatory factors produced by irradiation of complex LED light by time using ELISA kit for each inflammatory cytokine

HGF-1 cells were cultured under conditions of supplying 37 ° C and 5% CO ₂ using a medium containing 10% FBS and 1% penicillin / streptomycin in Dulbeco's modified eagle's medium (DMEM).

■ After dispensing HGF-1 cells in a 24-well plate at a concentration of 1 ㅧ 10 ⁵ cells / mL, incubate for 24 hours at 37 ℃, 5% CO ₂ , and induce P. Additional cultivation by treating gingivalis-Lipopolysaccharide (PG-LPS) 10 μg / mL and irradiating the complex LED light (A, B and C type) hourly (0 sec, 30 sec, 60 sec, 120 sec, 180 sec)

■ Anti-inflammatory effect evaluation was performed according to the ELISA kit manual, and the sample for each LED irradiation time was calculated by using the cell supernatant as a sample to calculate the cytokine content to evaluate the anti-inflammatory effect.

■ Anti-inflammatory evaluation of complex LED beams (A, B and C types) under all conditions was performed to select the optimal conditions for prototype production

3.3 Experimental results

■ IL-6 content decreased by 18.0% and 18.2% at A type 120 seconds and 180 seconds, respectively, compared to the untreated group not irradiated with light, and at B type, 120 seconds and 180 seconds at 11.9% and 11.7, respectively. %, And the C type showed a decrease of 18.4% and 18.7%, respectively, for 120 seconds and 180 seconds (Table 5).

The effect of LED light on p. gingivalis lipopolysaccharide (LPS) induced interleukine (IL) -6 in human gingival fibroblast Sample Irradiation Time (sec.) Concentration (pg / mL) A


0 8.92 ± 0.22 30 8.82 ± 0.10 60 7.71 ± 0.23 120 7.31 ± 0.19 180 7.30 ± 0.29 B 0 8.92 ± 0.22 30 8.90 ± 0.02 60 7.95 ± 0.23 120 7.86 ± 0.25 180 7.88 ± 0.11 C 0 8.92 ± 0.22 30 8.76 ± 0.12 60 7.41 ± 0.13 120 7.28 ± 0.05 180 7.25 ± 0.05

■ IL-1β production following irradiation of composite LED rays (A, B and C) showed a decrease of 8.2% and 11.2% in type A 120 seconds and 180 seconds, respectively, compared to the untreated group, and in the case of type B 120 seconds, The decrease of 3.9% and 4.3% was observed at 180 sec, respectively, and the C type showed inhibition of IL-1β production at 5.3% and 8.0% at 120 sec and 180 sec, respectively (Table 6).

The effect of LED light on p. gingivalis lipopolysaccharide (LPS) induced interleukine (IL) -1β in human gingival fibroblast Sample Irradiation Time (sec.) Concentration (pg / mL) A 0 19.61 ± 0.12 30 19.60 ± 0.88 60 18.04 ± 0.42 120 18.00 ± 0.24 180 17.42 ± 0.18 B 0 19.61 ± 0.12 30 19.53 ± 0.45 60 19.00 ± 0.11 120 18.85 ± 0.22 180 18.76 ± 0.85 C 0 19.61 ± 0.12 30 19.61 ± 0.15 60 19.06 ± 0.70 120 18.58 ± 0.63 180 18.05 ± 0.37

■ The IL-8 content of the composite LED light irradiation was 41.7% (A), 24.6% (B), and 42.6, respectively, compared to the untreated group that did not irradiate light based on the light irradiation time of 180 seconds in A and C types . It shows the inhibition rate of IL-8 production by% (C), and it was confirmed that it was significantly reduced by more than 40% in A type and C type (Table 7).

The effect of LED light on p. gingivalis lipopolysaccharide (LPS) induced interleukine (IL) -8 in human gingival fibroblast Sample Irradiation Time (sec.) Concentration (pg / mL) A 0 11.02 ± 0.52 30 10.28 ± 1.18 60 7.81 ± 1.25 120 6.54 ± 1.25 180 6.43 ± 1.53 B 0 11.02 ± 0.52 30 12.13 ± 0.52 60 10.07 ± 2.04 120 9.00 ± 0.91 180 8.31 ± 1.03 C 0 11.02 ± 0.52 30 10.83 ± 0.69 60 7.63 ± 1.55 120 6.46 ± 2.39 180 6.33 ± 1.11

In the case of TNF-α, TNF-α production inhibition rate of 35.8% (A) , 16.8% (B), and 20.7 (C), respectively, compared to the untreated group that did not irradiate the light based on 180 seconds of the composite LED light irradiation And, among them, high inhibition rate of production in A type (Table 8).

The effect of LED light on p. gingivalis lipopolysaccharide (LPS) induced tumor necrosis factor (TNF) -α in human gingival fibroblast Sample Irradiation Time (sec.) Concentration (pg / mL) A 0 33.82 ± 2.75 30 33.51 ± 0.32 60 29.40 ± 3.55 120 27.72 ± 2.09 180 21.71 ± 0.98 B 0 33.82 ± 2.75 30 33.72 ± 1.78 60 29.70 ± 0.52 120 28.44 ± 0.92 180 28.15 ± 0.79 C 0 33.82 ± 2.75 30 33.67 ± 1.23 60 28.39 ± 0.77 120 28.12 ± 0.84 180 26.83 ± 0.33

■ more comprehensively increase the light irradiation time were the production of cytokines make inhibited, among Type A and The inhibition rate of cytokine production in C type was high, and in particular, the arrangement and arrangement relationship between A, 1, 2, and 3 light source units of A type were superior to the anti-inflammatory effect at the same time. As an optimal light condition for the effect, it was proved that the improvement effect is excellent for periodontal disease according to the anti-inflammatory effect .

Judging from the results of these experiments, the cytotoxicity is prevented by using the wavelength of the visible light region irradiated by the first, second, and third light source units 310, 320, and 330, thereby minimizing side effects in oral care (ie, Cytotoxicity has not been found in normal cells).

In addition, by arranging three types of light sources in a square type (A type in this embodiment) to combine the reinforcing interference wavelengths, the optical power density of a predetermined size or more is secured to help eradicate or prevent various oral bacteria. Can be

As described above, the present invention has been described in detail using preferred embodiments, but the scope of the present invention is not limited to specific embodiments, and should be interpreted by the appended claims. In addition, those skilled in the art should understand that many modifications and variations are possible without departing from the scope of the present invention.

100: toothbrush body 110: body casing
120: Power switch 130: Excitation button
140: charging cradle 200: head casing
300: light irradiation module
310: first light source unit 311: first light source element
320: second light source unit
330: third light source unit 331: third light source element
340: PCB board 400: Excited member
410: ultrasonic ceramic piezoelectric element

Claims (8)

A toothbrush head portion 220 disposed on the head casing 200 of the toothbrush and detachably provided;
The first light source unit 310 and the second light source unit 320 and the third light source unit 330, which are disposed adjacent to the brush head 220 and have different wavelengths, are combined and combined with each other so that the light output density of a predetermined size or higher Light irradiation module 300 for irradiating the reinforcement interference wavelength of the; And
It is coupled to the light irradiation module 300 and includes an excitation member 400 to excite the bristles 220,
The brush head portion 220,
A bristles 221 arranged side by side in two rows on the central area of the plate casing 200 and coupled to the support plate 222; And
While receiving the support plate 222 and includes a connecting body 223 detachably coupled to the head casing,
The first light source unit 310, the second light source unit 320 and the third light source unit 330, the head casing in a position adjacent to the support plate 222, so that the light source of the light irradiation module 300 does not interfere ( 200),
The light irradiation module 300 further includes a PCB board 340 that is electrically connected to the first, second, and third light source units 310,320,330,
The first light source unit 310 is a pair of first LED light source elements 311 provided on the upper left and right when the brush head 220 is viewed from the front,
The second light source unit 320 is a second LED light source device provided at the bottom left of the bristle part 220,
The third light source unit 330 is made of a third LED light source element 331 provided at the bottom right of the brush head portion 220,
The first LED light source element 311 has a wavelength band for irradiating blue light (B) from 430 nm to 485 nm,
The second LED light source device has a wavelength band of 630 nm to 680 nm to irradiate red light (R),
The third LED light source element 331 is a three-color compound electric toothbrush for periodontal disease improvement and prevention, characterized in that the color temperature is 5000k to 8000k to irradiate white light (W).
delete delete delete delete According to claim 1,
The head casing 200 is provided with a plurality of step grooves 210 that are provided stepwise inward,
A multi-stage locking inclined surface 223 is formed on the connecting body 223 to lock and unlock the brush head portion 220 in the stepped groove portion 210,
The stepped groove portion 210 corresponding to the locking inclined surface 223 is a three-color compound electric toothbrush for periodontal disease improvement and prevention, characterized in that the inclined surface corresponding surface. The method of claim 6,
The locking inclined surface 223 and the inclined surface corresponding surface is provided in the thickness direction of the head casing 200 from the outer surface tapered toward one side, characterized in that the periodontal disease improvement and prevention three-color composite electric toothbrush. According to claim 1,
The excitation member 400 is a three-color composite electric toothbrush for periodontal disease improvement and prevention, characterized in that it is an ultrasonic ceramic piezoelectric element 410 that excites the bristle part 220 when the bristle part 220 is washed. .

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