KR102096391B9 - -3- Omega-3-fatty acid composition forming liquid crystal structures - Google Patents

-3- Omega-3-fatty acid composition forming liquid crystal structures

Info

Publication number
KR102096391B9
KR102096391B9 KR1020190125775A KR20190125775A KR102096391B9 KR 102096391 B9 KR102096391 B9 KR 102096391B9 KR 1020190125775 A KR1020190125775 A KR 1020190125775A KR 20190125775 A KR20190125775 A KR 20190125775A KR 102096391 B9 KR102096391 B9 KR 102096391B9
Authority
KR
South Korea
Prior art keywords
omega
liquid crystal
fatty acid
acid composition
crystal structures
Prior art date
Application number
KR1020190125775A
Other languages
English (en)
Other versions
KR102096391B1 (ko
Inventor
박영준
전상원
최숙
Original Assignee
(주)아이엠디팜
아주대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)아이엠디팜, 아주대학교산학협력단 filed Critical (주)아이엠디팜
Priority to KR1020190125775A priority Critical patent/KR102096391B1/ko
Application granted granted Critical
Publication of KR102096391B1 publication Critical patent/KR102096391B1/ko
Priority to AU2020361994A priority patent/AU2020361994A1/en
Priority to PCT/KR2020/011962 priority patent/WO2021071102A1/ko
Priority to US17/797,868 priority patent/US20230083019A1/en
Priority to EP20875299.8A priority patent/EP4062904A4/en
Priority to CA3173251A priority patent/CA3173251A1/en
Publication of KR102096391B9 publication Critical patent/KR102096391B9/ko

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1274Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020190125775A 2019-10-11 2019-10-11 액상결정 구조체를 형성하는 오메가-3-지방산 조성물 KR102096391B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020190125775A KR102096391B1 (ko) 2019-10-11 2019-10-11 액상결정 구조체를 형성하는 오메가-3-지방산 조성물
AU2020361994A AU2020361994A1 (en) 2019-10-11 2020-09-04 Liquid crystalline structure-forming omega-3-fatty acid composition
PCT/KR2020/011962 WO2021071102A1 (ko) 2019-10-11 2020-09-04 액상결정 구조체를 형성하는 오메가-3-지방산 조성물
US17/797,868 US20230083019A1 (en) 2019-10-11 2020-09-04 Liquid crystalline structure-forming omega-3-fatty acid composition
EP20875299.8A EP4062904A4 (en) 2019-10-11 2020-09-04 LIQUID CRYSTALLINE STRUCTURE-FORMING OMEGA-3 FATTY ACID COMPOSITION
CA3173251A CA3173251A1 (en) 2019-10-11 2020-09-04 Liquid crystalline structure-forming omega-3-fatty acid composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020190125775A KR102096391B1 (ko) 2019-10-11 2019-10-11 액상결정 구조체를 형성하는 오메가-3-지방산 조성물

Publications (2)

Publication Number Publication Date
KR102096391B1 KR102096391B1 (ko) 2020-04-06
KR102096391B9 true KR102096391B9 (en) 2022-09-30

Family

ID=70282247

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020190125775A KR102096391B1 (ko) 2019-10-11 2019-10-11 액상결정 구조체를 형성하는 오메가-3-지방산 조성물

Country Status (6)

Country Link
US (1) US20230083019A1 (ko)
EP (1) EP4062904A4 (ko)
KR (1) KR102096391B1 (ko)
AU (1) AU2020361994A1 (ko)
CA (1) CA3173251A1 (ko)
WO (1) WO2021071102A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102186704B1 (ko) * 2019-02-18 2020-12-04 (주)아이엠디팜 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물
KR102096391B1 (ko) * 2019-10-11 2020-04-06 (주)아이엠디팜 액상결정 구조체를 형성하는 오메가-3-지방산 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008646B2 (en) * 2001-02-20 2006-03-07 Patrick Thomas Spicer Cubic liquid crystalline compositions and methods for their preparation
KR100682531B1 (ko) * 2005-04-06 2007-02-15 유효경 양쪽성 계면활성제와 폴리올을 함유하는 가용화용나노조성물
KR100797985B1 (ko) * 2005-12-21 2008-01-28 주식회사 일신웰스 액정막 유화 조성물 및 그 제조방법
US9532963B2 (en) * 2009-03-09 2017-01-03 Pronova Biopharma Norge As Compositions comprising a fatty acid oil mixture and a free fatty acid, and methods and uses thereof
WO2012032417A2 (en) 2010-09-08 2012-03-15 Pronova Biopharma Norge As Compositions comprising a fatty acid oil mixture, a free fatty acid, and a statin
KR101586789B1 (ko) * 2012-12-28 2016-01-19 주식회사 종근당 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR102108154B1 (ko) 2017-02-08 2020-05-07 (주)동구바이오제약 개선된 생체이용률을 갖는 오메가-3 지방산 및 HMG-CoA 환원효소 억제제를 포함하는 약제학적 복합제제
KR102096391B1 (ko) * 2019-10-11 2020-04-06 (주)아이엠디팜 액상결정 구조체를 형성하는 오메가-3-지방산 조성물

Also Published As

Publication number Publication date
CA3173251A1 (en) 2021-04-15
WO2021071102A1 (ko) 2021-04-15
AU2020361994A1 (en) 2022-09-15
KR102096391B1 (ko) 2020-04-06
WO2021071102A9 (ko) 2021-05-14
EP4062904A4 (en) 2024-01-24
US20230083019A1 (en) 2023-03-16
EP4062904A1 (en) 2022-09-28

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