KR102090895B1 - Spherical granule manufacturing method of extracts and spherical granule manufacturing device used thereto - Google Patents

Abstract

The present invention provides a method for manufacturing spherical granules of extracts, and an apparatus used for manufacturing the same, wherein the manufacturing method includes the steps of: preparing extracts in the form of drops; dropping the extracts in the form of drops downward; solidifying through rapid cooling by introducing the extracts falling downward into a cryogen (liquid nitrogen) stored therein; recovering the solidified extracts; and lyophilizing the extracts. According to the present invention, by dropping the extracts to the cryogen in the form of drops in a predetermined amount to freeze the same in a spherical shape, spherical granules can be easily produced in a short time, thereby improving productivity.

Description

Spherical granule manufacturing method of extract and spherical granule manufacturing device used for manufacturing the same

The present invention relates to a method and apparatus for manufacturing spherical granules, and more specifically, by supplying X-agent to a Korean medicine (eg, liquid nitrogen) in the form of a drop, rapidly freezing, the spherical granules can be easily produced to increase productivity. The present invention relates to a method for manufacturing spherical granules of X-made and an apparatus for manufacturing spherical granules of X-made using the same.

In general, droplet generation is performed using a spray drying method, and the spray drying method atomizes the liquid material into small droplets (droplets) by a atomizer in hot air and sprays it to dry.

This spray drying method has a problem that it is difficult to control to uniformly generate droplet particles.

To solve this, electrostatic spraying technology is used, and electrostatic spraying technology is a method of atomizing and spraying a liquid using electric force, as described in Patent No. 10-1235865, microfluidic liquid having a monodisperse particle distribution. Enemies can be made.

In addition, the particles generated by electric force are charged with a single pole, and thus, there is an advantage in that it is easy to control the spatial dispersion property of the generated droplets.

However, this prior art does not solve the problem of extremely small supply flow.

Accordingly, there is an urgent need to develop a technology capable of uniformly and easily generating droplets of uniform particles to improve quality and productivity.

Accordingly, the present invention was devised to solve the above problems, and the X agent supply unit for supplying the X agent in the form of a droplet, and a cooling space part opened upward in the inside, thereby forming a Korean medicine (eg, liquid nitrogen). The water is stored, and the X-type cooling unit for cooling the droplet-type X-Ze supplied from the X-Z supply unit into spherical droplets. , It is an object of the present invention to provide an apparatus for manufacturing spherical granules of X-made and a method of manufacturing spherical granules of X-made using the same, which can easily make droplets in a short time and improve productivity.

Method for producing spherical granules of X-made of the present invention for achieving the above object,

Preparing the ex-je in the form of drops;

Dropping the X-shaped drops downwards;

A step of solidifying through the rapid cooling by putting the X agent falling downward into liquid nitrogen stored downward;

Recovering the solidified ex-agent; And

And lyophilizing the X agent.

In addition, the apparatus for manufacturing spherical granules of X made according to the present invention for use in the above method includes an X-made supply part for supplying the X-made in a droplet form (droplet), and a cooling space part opened upwardly inside the Chinese medicine. It is stored, and includes an X agent cooling unit for cooling the droplet-type X agent supplied from the X agent supply unit into spherical granules.

Preferably, the cryogen of the X-made cooling unit is liquid nitrogen.

In addition, the X-J supply unit, the X-J tank for storing the X-J, and the X-J transfer unit for dropping the X-J of the X-J tank into the cooling unit of the X-J, and dropping it in a droplet form (droplet). Includes.

In addition, the said X agent is semi-solid soft extract.

And the annual extract contains 30 to 50% moisture.

In addition, the transfer agent of the X agent, the transfer cradle located on the upper side of the cooling agent of the X agent, has flexibility, one end is connected to the X agent tank, and the other end is fixed to the transfer holder and the X agent of the X agent tank And a plurality of transfer tubes for dropping the cooling agent to the X-made cooling unit, and a quantitative transfer driving unit for transferring the X-agent by a predetermined amount by applying pressure to the other end of the transfer tube fixed to the transfer cradle.

In addition, the quantitative transfer driving unit is a peristaltic pump.

In addition, the granules moving unit for moving and drying the granules cooled by the X-made cooling unit further includes.

And the granule moving part, one end is located on the bottom surface of the cooling space of the cooling agent of the X agent, the other end is provided with an inclined so as to be located outside the cooling agent of the X agent, a plurality of granules are formed at regular intervals along the granule conveyor It includes a moving jaw, and a granule moving driving unit for rotating the granular conveyor.

In addition, the X-made cooling unit further includes a water level control unit for adjusting the water level of the Chinese medicine stored in the cooling space.

And the X-je filling step of filling the X agent in the X agent supply unit of the spherical granule manufacturing apparatus of claim 2 to 7, the cooling agent of the cooling unit of the cooling agent of the X agent of the spherical granule manufacturing apparatus of claims 1 to 6 For the Chinese medicine filling step, and the X-agent supply portion of the X-agent dropped into the filled agent of the X-agent cooling unit, dropping in the form of drops, when in contact with the Chinese agent, granules forming step of cooling into spherical granules, including do.

In addition, the granule forming step, the X-preparation step of transferring the X-agent so as to fill a plurality of transport tubes by the quantitative transfer driving unit of the X-agent supply unit, and the X-agent into a plurality of transport tubes by the quantitative transfer driving unit In accordance with the quantitative supply, the dropping step of forming the spherical granules by dropping the agent in the form of a dropping agent in the form of a dropping agent, includes.

And further comprising a granule transfer step, the granules formed in the granulation step is moved by the granule moving unit of the spherical granule manufacturing apparatus of claim 2 to 7.

As described above, according to the apparatus for manufacturing spherical granules of X-made according to the present invention and a method of manufacturing spherical granules of X-made using the same, as the drops of X-Je are dropped into Korean medicine in a certain amount of drops and freezes into a spherical shape, spherical It is a very useful and effective invention that makes it easy to make granules in a short time to improve productivity.

1 is a view showing an apparatus for manufacturing spherical granules made of X according to the present invention,
2 is a view showing an X-made supply unit according to the present invention,
3 is a view showing a granule moving part of the cooling agent made of X according to the present invention,
4 is a view showing a state in which the water level control unit is further provided in the X-made cooling unit according to the present invention,
5 is a detailed view showing a preferred embodiment of the granule moving part of the cooling agent according to the present invention,
6 is a view showing a method of manufacturing spherical granules made of X according to the present invention,
7 is a view showing a granulation step according to the present invention,
8 is a view showing a manufacturing method further includes a granulation transfer step according to the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. DETAILED DESCRIPTION The detailed description set forth below, in conjunction with the accompanying drawings, is intended to describe exemplary embodiments of the invention, and is not intended to represent the only embodiments in which the invention may be practiced. The following detailed description includes specific details to provide a thorough understanding of the present invention. However, one of ordinary skill in the art to which the present invention pertains knows that the present invention may be practiced without these specific details.

In some cases, in order to avoid obscuring the concept of the present invention, well-known structures and devices may be omitted, or block diagrams centered on the core functions of each structure and device may be illustrated.

Throughout the specification, when a part "comprising or including" a certain component, it means that other components may be further included instead of excluding other components, unless otherwise specified. do. In addition, the term "… part" described in the specification means a unit that processes at least one function or operation. In addition, "a (a or an)", "one (one)," "the (the)" and similar related terms in the context of describing the present invention (especially in the context of the following claims) are different herein. It can be used in a sense including both singular and plural unless indicated or clearly contradicted by context.

In describing embodiments of the present invention, when it is determined that a detailed description of known functions or configurations may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. In addition, terms to be described later are terms defined in consideration of functions in an embodiment of the present invention, which may vary according to a user's or operator's intention or practice. Therefore, the definition should be made based on the contents throughout this specification.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

1 is a view showing a device for manufacturing spherical granules of X made according to the present invention, FIG. 2 is a view showing a supply of X made according to the present invention, and FIG. 3 is a granulator moving part of the cooling agent made of X made according to the present invention. 4 is a view showing a state in which the water level control unit is further provided in the cooling agent according to the present invention, and FIG. 5 is a detailed view showing a preferred embodiment of the granule moving part of the cooling agent according to the invention Fig. 6 is a view showing a method for manufacturing spherical granules made of X according to the present invention, Fig. 7 is a view showing a granulation step according to the present invention, and Fig. 8 is a granulation transfer step according to the present invention It is a view showing a manufacturing method further included.

As shown in the figure, the X-shaped spherical granule manufacturing apparatus 10 includes an X-made supply unit 100 and an X-made cooling unit 200.

The X agent supply unit 100 is provided to supply the X agent in the form of drops.

In addition, the cooling agent 200 of the X agent 200 is formed with a cooling space part 202 open upwards therein to store the cryogen, and to cool the droplet-type X agent supplied from the X agent supply unit 100 into spherical granules. It is provided for.

The X-made cooling unit 200 is formed of a water tank-shaped cooling body 210.

Here, the ex-agent is preferably a semi-solid lead extract containing 30 to 50% moisture.

In addition, the Chinese medicine of the cooling agent 200 of X-X is liquid nitrogen, and the X-X supplied in the form of drops is rapidly frozen and then dried in a freeze dryer.

For this, the X agent supply unit 100 is composed of an X agent tank 110 and an X agent transfer unit 120, as shown in FIG. 2.

The X-je tank 110 is stored as the X-je, and is formed so that the lower end gradually decreases toward the lower side.

In addition, the X-J transfer unit 120 is transferred to the X-J cooling unit 200 by transferring the X-J of the X-J tank 110 by a predetermined amount, and is provided to drop in the form of drops.

The X-made transfer unit 120 includes a transfer cradle 122, a transfer tube 124, and a quantitative transfer drive unit 126.

The transfer cradle 122 is located above the X-made cooling unit 200.

In addition, the transfer tube 124 has flexibility, one end is connected to the X-made tank 110, the other end is fixed to the transfer cradle 122, the X-made of the X-made tank 110, the X-made cooling unit 200 ) Is provided for plural drops.

The quantitative transfer driving unit 126 is provided to transfer the X-agent by a predetermined amount by applying pressure to the other end of the transfer tube 124 fixed to the transfer cradle 122.

The quantitative transfer driving unit 126 may use a peristaltic pump.

And, as illustrated in FIG. 3, the X-made cooling unit 200 further includes a granule moving unit 220.

The granule moving unit 220 is provided to move and dry the granules cooled by the X-made cooling unit.

The granule moving part 220 includes a granule conveyor 222, a moving jaw 224, and a granule moving driving part 226.

The granular conveyor 222 is inclined such that one end is located on the bottom surface of the cooling space 202 of the X-je cooling unit 200, and the other end is located on the outside of the X-je cooling unit 200.

In addition, a plurality of moving jaws 224 are formed at regular intervals along the granular conveyor 222.

The granule movement driving unit 226 is provided to rotate the granule conveyor 222.

Here, the granular conveyor 222 includes a first granulated conveyor 222a, a second granulated conveyor 222b, and a third granulated conveyor 222c.

The first granule conveyor 222a is positioned parallel to the bottom surface of the cooling space part 202 of the cooling body 210 and is provided to horizontally move the granules provided in the cooling space part 202.

In addition, the second granular conveyor 222b is inclined such that one end is connected to the first granular conveyor 222a and the other end is provided outside the cooling body 210.

The third granule conveyor 222c has one end connected to the other end of the second granule conveyor 222b, and is provided in a horizontal direction so that the granules are discharged through the other end.

In addition, as illustrated in FIG. 4, the X-made cooling unit 200 further includes a water level control unit 300.

The water level control unit 300 is provided to control the water level of the cold water stored in the cooling space 202 of the X-made cooling unit 200.

The water level control unit 300 includes a water level sensor 310, a Korean medicine supply unit 320, and a water level control unit 330.

The water level sensor 310 is provided in the cooling body 210 of the X-made cooling unit 200.

The water level sensor 310 is provided along the height direction of the outer surface of the cooling body 210.

And the cold agent supply unit 320 is provided to supply the cold agent to the cooling space portion 202 of the cooling body 210.

The water level control unit 330 is provided to receive the signal from the water level sensor 310 and control the cold water supply unit 320.

The water level control unit 330 receives the signal from the water level sensor 310 to check the temperature boundary surface due to the stored cold water of the cooling body 210, checks the water level, and controls the cold water supply unit 320 to adjust the proper water level do.

5 is a detailed drawing showing a preferred embodiment of the granule moving part of the X-made cooling unit according to the present invention, and relates to a special structure of the moving jaw 224 and the granular conveyor 222. This structure reduces the influence of the fluid flow caused by the movement of the moving jaw at the stage where spherical droplets are introduced into the tablet, minimizing the phenomenon of dropping and entanglement with each other while simultaneously aligning the granules in a row. Disclosed is a configuration capable of preventing the phenomenon of granule aggregation.

In more detail, the moving jaw 224 is formed with slits 224c of a straight line at regular intervals on the surface. The width of the slit 224c is less than or equal to the diameter of the granules, while preventing the granules from escaping through the slit, allowing the Korean agent (eg, liquid nitrogen) to pass freely to minimize fluid flow.

In addition, the granular conveyor 222 has a regular interval with the floor 222-1 and the bone 222-2 alternately formed in the traveling direction so that the spherical granules can be aligned in a row in the bone 222-2. . Preferably, each end of the slit 224c of the moving jaw 224 is matched with each bone 222-2 of the granular conveyor 222.

The upper end of the movable jaw 224 is formed with a bent portion 224a so that the movable jaw 224 can be recovered by scraping and recovering spherical granules that can accumulate on the bottom surface of the cooling body as the traveling jaw progresses downward. The end of the bent portion 224a forms a concave portion 224b with a predetermined interval so that the spherical granules can be positioned in the concave portion. Preferably, the concave portion 224b is configured to be matched with the upper end of the slit 224c, thereby moving the granules recovered in each concave portion 224b to each matching slit 224c, and moving jaw ( The granules located in each slit 224c while the 224) is positioned upward may be moved and transported to each bone 222-2 of the granule conveyor 222. To this end, the slit 224c is preferably so that both sides of the slit have a slope so that the granules can be safely received.

This configuration of the present invention not only can safely recover the granules that can fall on the floor, but also provides the advantage of minimizing the flow of Korean medicine and transporting them by accurately positioning them in a line while minimizing the aggregation between the granules. do.

Looking at the method for manufacturing spherical granules of X-made using the spherical granule manufacturing apparatus 10 of the X-made, as shown in FIG. 6, the X-je filling step (S10) and the Korean medicine filling step (S20) and granulation step ( S30).

The X agent filling step (S10) is to fill the X agent into the X agent supply unit 100 of the spherical granule manufacturing apparatus 10, and to fill the X agent tank 110 with the X agent.

In addition, the Chinese medicine filling step (S20) fills the Korean medicine with the cooling space portion 202 of the X-made cooling portion 200 of the spherical granule manufacturing apparatus 10.

In the granulation step (S30), the X agent of the X agent supply unit 100 is dropped into the filled Korean agent of the X agent cooling unit 200. do.

Accordingly, a plurality of droplets of a spherical shape can be formed in a large amount by dropping a plurality of ex-agents at regular intervals. Preferably, in the case of preparing n 으로 n nozzles in a square shape, it is recommended that the cooling unit 200 may be uniformly dropped.

For this, the granulation step (S30), as shown in FIG. 7, includes an X preparation step (S31) and an X preparation dropping step (S32).

In the X preparation step (S31), the X agent is transported to fill a plurality of transport tubes 124 by the quantitative transfer driving unit 126 of the X agent supply unit 100.

In addition, in the step of dropping the X-agent (S32), as the X-agent is quantitatively supplied to the plurality of transport tubes 124 by the quantitative transport driving unit 126, the X-agent is dropped into a Chinese medicine in the form of drops to form spherical granules.

In addition, as shown in FIG. 8, the method for manufacturing spherical granules of X using the spherical granule manufacturing apparatus 10 of X is further included in the granulation transfer step (S40).

In the granule transfer step (S40), the granules formed in the granulation step (S30) are moved by the droplet moving part 220 of the spherical granule manufacturing apparatus 10.

The granules thus transferred are recovered and then dried using freeze-drying or other known drying methods to obtain the desired ex-granule granules. The device and method according to the present invention is the manufacture of a food or pharmaceutical product requiring spherical granules. It can be widely used.

10: spherical granule manufacturing apparatus 100: X-made supply unit
110: X-je tank 120: X-je transfer unit
200: X-made cooling unit 210: cooling body
220: granule moving part 300: water level control part
310: water level sensor 320: Korean medicine supply
330: water level control unit

Claims (10)

Preparing the ex-je in the form of drops;
Dropping the X-shaped drops downwards;
A step of solidifying through the rapid cooling by putting the X agent falling downward into liquid nitrogen stored downward;
Recovering the solidified ex-agent; And
In the method comprising the; drying the ex-agent;
X-shaped spherical granule manufacturing apparatus for use in the above method,
An X agent supply unit for supplying the X agent in a droplet form (droplet); And
Includes a cooling agent for cooling the upper portion of the cooling agent is formed in the upper side is stored in the inside, the cooling agent for cooling the droplet-shaped X agent supplied from the X agent supply unit into spherical granules.
The X-made supply unit,
The X-ze tank in which the X-ze is stored; And
Containing; by transferring a certain amount of the X agent of the X agent tank and dropping it to the X agent cooling unit, the X agent transport unit for dropping in the form of drops;
Further comprising a granule moving unit for drying by moving the granules cooled by the X-made cooling unit,
The granule moving part,
A granular conveyor having one end positioned at the bottom of the cooling space part of the cooling agent of the X agent and inclined so that the other end is located outside the cooling agent of the X agent;
A plurality of moving jaws formed at regular intervals along the granular conveyor; And
It includes; a granule moving drive unit for rotating the granule conveyor;
The movable jaw is formed with a plurality of slits of a straight line at regular intervals on the surface, and the width of each slit is less than the diameter of the granules, preventing the granules from escaping, and allowing the Chinese medicine to pass freely, thereby allowing the flow of fluid to pass. Minimize,
In the granular conveyor, the floor and the bone are alternately formed in the traveling direction at regular intervals so that the spherical granules can be aligned in a row, and each end of each slit of the moving jaw matches each bone of the granular conveyor. ,
The upper end of the movable jaw is formed with a bent portion so that the movable jaw can be recovered by scratching the spherical granules that can accumulate on the bottom surface of the cooling body while traveling downward.
A concave portion with a predetermined interval is formed at the end of the bent portion so that the spherical granules can be positioned in the concave portion, but the concave portion is matched with the upper end of the slit and the granules recovered in each concave portion are matched with the corresponding slit. Will be moved,
While the moving jaw is positioned upward by the granular conveyor, the granules located in each slit are moved to each bone of the granular conveyor and transferred,
The concave portion is a method for manufacturing spherical granules made of X, characterized in that both sides of the slit have a slope to safely receive the granules. delete delete According to claim 1, The X-made transfer unit,
A transfer cradle located above the X-made cooling unit;
A plurality of transfer tubes having flexibility, one end connected to the X-Je tank, and the other end fixed to the transfer cradle to drop the X-J of the X-Je tank to the X-J cooling section; And
X-shaped spherical granules manufacturing method comprising; a quantitative transfer drive unit for transferring a certain amount of X-je by applying pressure to the other end of the transport tube fixed to the transport cradle. delete delete According to claim 1,
A method for manufacturing spherical granules of X made further comprising; a water level adjusting part for adjusting the water level of the Chinese medicine stored in the cooling space part of the cooling part of the X agent. delete delete delete

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