KR102075443B1 - Hydrogel composite and preparing method thereof - Google Patents

Abstract

The present application relates to a hydrogel composite, wherein a one-dimensional nano-chain structure wrapped by a polymer is dispersed on a hydrogel substrate. The hydrogel composite according to the present application allows the one-dimensional nano-chain structure to be uniformly coated (wrapped) by gelatin through the chemical bonding between an amine group of gelatin and the one-dimensional nano-chain structure.

Description

HYDROGEL COMPOSITE AND PREPARING METHOD THEREOF

The present application relates to a hydrogel complex and a method for preparing the same.

Hydrogel is a three-dimensional porous polymer composite containing a large amount of water. Hydrogels are similar to the human body because they contain a large amount of water, and because of their properties, they are widely used in biotechnology such as drug delivery and tissue engineering.

In particular, natural polymers such as gelatin and chitosan are actively used in bio research because of their high biocompatibility. However, natural polymer hydrogel, which is commonly studied, has remarkably low mechanical strength and brittleness, and its application is limited. Therefore, research on a method of preparing natural polymer hydrogel has been actively conducted to overcome this problem.

Currently, researches using nanomaterials such as carbon nanotubes or graphene as hydrogel filters to improve the mechanical strength of natural polymer hydrogels have been conducted. However, in the case of graphene, it is difficult to expect a dramatic improvement in the strength of the natural polymer hydrogel because it does not mix uniformly with the polymer having a linear structure and has difficulty in water dispersion.

Development of a functionalized multi-walled carbon-nanotube-based alginate hydrogels for enabling biomimetic technologies is a background technology of the present application relates to multi-walled carbon nanotube-based alginate hydrogels. This paper discloses a hydrogel composite with superior mechanical, physical and biological properties compared to pure alginate by adding functionalized multiwalled carbon nanotubes to alginate.

The present application is to solve the above-mentioned problems of the prior art, an object of the present invention to provide a hydrogel composite and a method for producing the same.

However, the technical problem to be achieved by the embodiments of the present application is not limited to the technical problems as described above, and other technical problems may exist.

As a technical means for achieving the above technical problem, the first aspect of the present application provides a hydrogel composite, wherein the one-dimensional nano-chain structure wrapped by the polymer is dispersed on the hydrogel substrate.

According to one embodiment of the invention, the one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I ₈ , TaSe ₃ , TiS ₃ , NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof may be included, but is not limited thereto.

According to one embodiment of the present application, the polymer may include an amine group, but is not limited thereto.

According to one embodiment of the present application, the polymer may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the hydrogel substrate may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the one-dimensional nano-chain structure may have a diameter of 10 nm or less, but is not limited thereto.

According to one embodiment of the present application, the one-dimensional nano-chain structure may be one that does not have a side dangling bond, but is not limited thereto.

A second aspect of the present disclosure includes the steps of wrapping the one-dimensional nano chain structure with a polymer; And dispersing the one-dimensional nano-chain structure wrapped with the polymer on a hydrogel substrate.

According to one embodiment of the invention, the one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I ₈ , TaSe ₃ , TiS ₃ , NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof may be included, but is not limited thereto.

According to one embodiment of the present application, the polymer may include an amine group, but is not limited thereto.

According to one embodiment of the present application, the polymer may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the hydrogel base may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the concentration of the one-dimensional nano-chain structure may be 0.003 wt% to 0.05 wt%, but is not limited thereto.

According to one embodiment of the present application, in the step of wrapping the one-dimensional nano-chain structure by the polymer may be uniformly wrapped by the chemical bond between the amine group and the one-dimensional nano-chain structure of the polymer, but is not limited thereto.

According to one embodiment of the present application, the one-dimensional nano-chain structure may be one that does not have a side dangling bond, but is not limited thereto.

According to one embodiment of the present application, the one-dimensional nano-chain structure may have a diameter of 10 nm or less, but is not limited thereto.

The above-mentioned means for solving the problems are merely exemplary, and should not be construed as limiting the present application. In addition to the above-described exemplary embodiments, additional embodiments may exist in the drawings and detailed description of the invention.

According to the aforementioned problem solving means of the present application, the hydrogel complex according to the present application may be uniformly coated (wrapped) by gelatin by chemical bonding between the amine group of the gelatin and the one-dimensional nano chain structure.

Furthermore, the hydrogel composite of the present application can improve the elastic modulus by 326% compared to the conventional hydrogel through the excellent strength of the one-dimensional nano-chain structure and the chemical bonding of the one-dimensional nano-chain structure and gelatin, and improves toughness. 695% improvement.

However, the effects obtainable herein are not limited to the effects as described above, and other effects may exist.

1 is a schematic diagram showing the structure of a hydrogel composite according to an embodiment of the present application.
Figure 2 is an optical photograph of the hydrogel, one-dimensional nano-chain structure dispersion solution and the hydrogel composite according to an embodiment of the present application.
(A) and (b) of Figure 3 is a scanning electron microscope (SEM) image of the hydrogel complex according to a comparative example of the present application.
Figure 4 is a graph of the mechanical strength measurement results of the hydrogel composite according to one embodiment and comparative example of the present application.
5 is a zeta potential measurement result and a transmission electron microscope (TEM) image of a one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) wrapped by a polymer according to an embodiment of the present disclosure.
Figure 6 (a) is a view showing the porous structure of the hydrogel composite according to a comparative example of the present application, Figure 6 (b) shows the porous structure and the detailed structure of the hydrogel composite according to an embodiment of the present application Drawing.
7 is a mechanical strength measurement photograph and mechanical strength measurement result graph of the hydrogel composite according to an embodiment of the present application.
8 is a graph of the mechanical strength measurement results of the hydrogel composite according to an embodiment of the present application.
9 is a scanning electron microscope (SEM) image showing a change in the porous structure according to the concentration of the one-dimensional nano-chain structure of the hydrogel composite according to an embodiment of the present application.
10 (a) to (d) is a graph of strength improvement of the hydrogel composite according to the Examples and Comparative Examples of the present application.

DETAILED DESCRIPTION Hereinafter, exemplary embodiments of the present disclosure will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present disclosure. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. In the drawings, parts irrelevant to the description are omitted for simplicity of explanation, and like reference numerals designate like parts throughout the specification.

Throughout this specification, when a part is "connected" to another part, this includes not only "directly connected" but also "electrically connected" with another element in between. do.

Throughout this specification, when a member is said to be located on another member "on", "upper", "top", "bottom", "bottom", "bottom", this means that any member This includes not only the contact but also the case where another member exists between the two members.

Throughout this specification, when a part is said to "include" a certain component, it means that it can further include other components, without excluding the other components unless otherwise stated.

As used herein, the terms "about", "substantially", and the like, are used at the numerical values of, or in the vicinity of, numerical values when manufacturing and material tolerances inherent in the meanings mentioned are provided to aid the understanding herein. In order to prevent an unscrupulous infringer from unfairly using the disclosed disclosure. In addition, throughout this specification, "step to" or "step of" does not mean "step for."

Throughout this specification, the term "combination of these" included in the expression of the makushi form refers to one or more mixtures or combinations selected from the group consisting of constituents described in the expression of the makushi form, wherein the constituents It means to include one or more selected from the group consisting of.

Throughout this specification, description of "A and / or B" means "A or B, or A and B."

Hereinafter, the hydrogel composite of the present application and a method for preparing the same will be described in detail with reference to embodiments, examples, and drawings. However, the present application is not limited to these embodiments, examples, and drawings.

As a technical means for achieving the above technical problem, the first aspect of the present application provides a hydrogel composite, wherein the one-dimensional nano-chain structure wrapped by the polymer is dispersed on the hydrogel substrate.

Hydrogel is a three-dimensional porous polymer composite containing a large amount of water. Hydrogels are similar to the human body because they contain a large amount of water, and because of their properties, they are widely used in biotechnology such as drug delivery and tissue engineering. In particular, natural polymers such as gelatin and chitosan are actively used in bio research because of their high biocompatibility. However, natural polymer hydrogel, which is commonly studied, has a significantly low mechanical strength and brittleness, and its application is limited, so researches on a natural polymer hydrogel manufacturing method for overcoming it have been actively studied.

Currently, researches using nanomaterials such as carbon nanotubes or graphene as fillers or additives for hydrogels have been conducted to improve the mechanical strength of natural polymer hydrogels. However, in the case of graphene, it is difficult to expect a dramatic improvement in the strength of the natural polymer hydrogel because it does not mix uniformly with the polymer having a linear structure and has difficulty in water dispersion.

Since nanowires such as carbon nanotubes and SiO ₂ have one-dimensional structural characteristics, researches on using them as fillers or additives for hydrogels have been conducted. However, these nanowires also have problems with large scale differences and weak chemical bonds with polymers, which makes it difficult to sufficiently improve the mechanical strength of the hydrogel.

1 is a schematic diagram showing the structure of a hydrogel composite according to an embodiment of the present application. Referring to FIG. 1, the one-dimensional nano chain structure (Mo ₃ Se ₃ ⁻ ) wrapped with gelatin inside the gelatin hydrogel composite having a porous structure shows homogeneous mixing, and the one-dimensional nano chain. indicates that 0.6 nm, similar to the diameter of the gelatinous polymer structure (Mo ₃ Se ₃ ^{- -)} of the one-dimensional nano-structure chain through (d) of Figure 1 shows the crystal structure (Mo ₃ Se _3).

According to one embodiment of the invention, the one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I ₈ , TaSe ₃ , TiS ₃ , NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof may be included, but is not limited thereto. Preferably, the one-dimensional nano-chain structure may be one containing Mo ₃ Se ₃ ⁻ . The one-dimensional nano-chain structure may have the same scale as the polymer.

According to one embodiment of the present application, the polymer may include an amine group, but is not limited thereto. Through the chemical bonding between the amine group of the polymer and the one-dimensional nano chain structure, the one-dimensional nano chain structure can be uniformly wrapped by the polymer.

Furthermore, the hydrogel composite of the present invention can improve the elastic modulus of the elastic modulus by about 326% and toughness through the excellent strength of the one-dimensional nano-chain structure and the chemical bonding of the one-dimensional nano-chain structure and the polymer. Can improve about 695%.

According to one embodiment of the present application, the polymer may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof. Preferably, the polymer may be one containing gelatin.

According to one embodiment of the present application, the hydrogel base may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the one-dimensional nano-chain structure may have a diameter of 10 nm or less, but is not limited thereto. Specifically, the one-dimensional nano chain structure may be one having a diameter of 0.1 nm to 10 nm. Preferably, the one-dimensional nano-chain structure may have a diameter of 1 nm.

According to one embodiment of the present application, the one-dimensional nano-chain structure may be one that does not have a side dangling bond, but is not limited thereto.

Dangling bond is a kind of surface defect and means a portion where an atom is broken. Atoms on the crystal surface or in the bonds in the crystal are in a state where some bonds are cleaved due to coordination unsaturation, unlike atoms in the complete crystal. This cleaved bond is generally referred to as dangling bond. When atoms or molecules approach the dangling bond, they form a chemical bond easily. Accordingly, the electronic device including the material in which the dangling bond is present may decrease electrical, physical, mechanical, and chemical properties by an external environment, for example, air or moisture. In order to prevent deterioration of the electronic device due to the dangling bond, a portion in which the dangling bond exists may be combined with another material to minimize deterioration in performance.

A second aspect of the present disclosure includes the steps of wrapping the one-dimensional nano chain structure with a polymer; And dispersing the one-dimensional nano-chain structure wrapped with the polymer on a hydrogel substrate.

According to one embodiment of the invention, the one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I ₈ , TaSe ₃ , TiS ₃ , NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof may be included, but is not limited thereto. Preferably, the one-dimensional nano-chain structure may be one containing Mo ₃ Se ₃ ⁻ .

According to one embodiment of the present application, the polymer may include an amine group, but is not limited thereto.

According to one embodiment of the present application, in the step of wrapping the one-dimensional nano-chain structure by the polymer may be uniformly wrapped by the chemical bond between the amine group and the one-dimensional nano-chain structure of the polymer, but is not limited thereto.

Furthermore, according to the manufacturing method of the hydrogel composite of the present invention, it is possible to improve the elastic modulus (Elastic modulus) by about 326% through the excellent strength of the one-dimensional nano-chain structure and chemical bonding of the one-dimensional nano-chain structure and the polymer. Hydrogel composite can improve the toughness (Toughness) about 695%.

According to one embodiment of the present application, the polymer may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof. Preferably, the polymer may be one containing gelatin.

According to one embodiment of the present application, the hydrogel base may include, but is not limited to, a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.

According to one embodiment of the present application, the concentration of the one-dimensional nano-chain structure may be 0.003 wt% to 0.05 wt%, but is not limited thereto.

For example, the concentration of the one-dimensional nano-chain structure is 0.003 wt% to 0.05 wt%, 0.003 wt% to 0.04 wt%, 0.003 wt% to 0.03 wt%, 0.003 wt% to 0.02 wt%, 0.004 wt% to 0.05 wt %, 0.005 wt% to 0.05 wt%, 0.006 wt% to 0.05 wt%, 0.007 wt% to 0.05 wt%, 0.008 wt% to 0.05 wt%, 0.009 wt% to 0.05 wt%. Preferably, the concentration of the one-dimensional nano-chain structure may be 0.01 wt%.

According to one embodiment of the present application, the one-dimensional nano-chain structure may be one that does not have a side dangling bond, but is not limited thereto.

Dangling bond is a kind of surface defect and means a portion where an atom is broken. Atoms on the crystal surface or in the bonds in the crystal are in a state where some bonds are cleaved due to coordination unsaturation, unlike atoms in the complete crystal. This cleaved bond is generally referred to as dangling bond. When atoms or molecules approach the dangling bond, they form a chemical bond easily. Accordingly, the electronic device including the material in which the dangling bond exists may have electrical, physical, mechanical, and chemical properties deteriorated by an external environment, for example, air or moisture. In order to prevent deterioration of the electronic device due to the dangling bond, a portion in which the dangling bond exists may be combined with another material to minimize deterioration in performance.

According to one embodiment of the present application, the one-dimensional nano-chain structure may have a diameter of 10 nm or less, but is not limited thereto. Specifically, the one-dimensional nano chain structure may be one having a diameter of 0.1 nm to 10 nm. Preferably, the one-dimensional nano-chain structure may have a diameter of 1 nm.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the following examples are for illustrative purposes only and are not intended to limit the scope of the present application.

EXAMPLE

Example 1- (1): one-dimensional nano-structure chain (Mo ₃ Se ₃ ^-) solution prepared

One-dimensional nano-chain structure (Mo ₃ Se ₃ ^-) is a single crystal LiMo ₃ Se ₃ ^- chromatography step using the after ultrasonic dispersion in distilled water at a concentration of 0.01 wt%, to separate 10 minutes and centrifuged at 10,000 rpm, the lithium ion-exchange resin Prepared by removing lithium.

Example 1- (2): Wrapping of One ^- Dimensional Nano Chain Structure (Mo ₃ Se _3- )

The Mo ₃ Se ₃ ⁻ solution dispersed in DI water at 0.01 wt% was mixed with a gelatin solution dissolved in distilled water at a concentration of 0.25 wt%, followed by ultrasonic dispersion for 30 minutes, and then stirred for 90 minutes.

Example 1- (3): one-dimensional nano-structure chain (Mo ₃ Se ₃ ^-) / gelatin hydrogel complexes prepared

Gelatin powder was further added to the gelatin-wrapped one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) solution and dissolved at a temperature of 70 ° C. to prepare a final gelatin concentration of 15 wt%. One-dimensional nano-structure chain (Mo ₃ Se ₃ ^-) / into the gelatin mixture in the mold to polymerize the reaction mixture was cooled at 4 ℃.

[Comparative Example]

The Mo ₃ Se ₃ ⁻ solution dispersed in DI water at 0.01 wt% was mixed with the gelatin solution dissolved in distilled water to prepare a final gelatin concentration of 15 wt%. Thereafter, the mixture was heated at a temperature of 70 ° C. or higher, put in a mold, cooled at 4 ° C., and polymerized.

 Experimental Example

Figure 2 is an optical photograph of the hydrogel, one-dimensional nano-chain structure dispersion solution and the hydrogel composite according to an embodiment of the present application. Referring to Figure 2, it can be seen that the hydrogel complex became brown due to the dark red color of the Mo ₃ Se ₃ ^- dispersion solution.

(A) and (b) of Figure 3 is a scanning electron microscope (SEM) image of the hydrogel complex according to a comparative example of the present application. Referring to (a) and (b) of FIG. 3, in the case of FIG. 3 (a) in which the composite is prepared after wrapping the one ^- dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) with gelatin (Example of the present application), It can be seen that the phase separation of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) and gelatin is uniformly mixed without occurring, and in the case of (b) of FIG. 3 (other comparative example), It can be seen that the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) was phase separated from the gelatin matrix.

Figure 4 is a graph of the mechanical strength measurement results of the hydrogel composite according to one embodiment and comparative example of the present application. 4, the hydrogel complex according to one embodiment of the present application ^- is manufactured without _{(Mo 3 Se 3 0.05%,} 0.01%, 0.003%) , while as a tensile strength, but increases the fracture strain, one-dimensional nano-chain structure hydrogel ^{_{(Mo 3 Se 3 - 0%}} ) can be confirmed that the fracture strain decreased. When the concentration of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) is 0.01 wt% or more, both tensile strength and breaking strain began to decrease.

5 is a zeta potential measurement result and a transmission electron microscope (TEM) image of a one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) wrapped by a polymer according to an embodiment of the present disclosure. Referring to FIG. 5, the potential of the pure one-dimensional nanochain structure (gelatin: Mo ₃ Se ₃ ⁻ = 0: 100) was −48.1 mV, and became positive as the amount of gelatin increased, and gelatin and Mo ₃ Se ₃ ⁻ When the ratio of 25:75 was saturated to 7.2 mV. These results show that the negative Mo ₃ Se ₃ ^- nano chain structure was wrapped with a positive gelatin polymer in the lapping process. In addition, it can be seen from the transmission electron microscope image that Mo ₃ Se ₃ ^- nano-chain structure is completely wrapped with gelatin polymer.

Figure 6 (a) is a view showing the porous structure of the hydrogel composite according to a comparative example of the present application, Figure 6 (b) shows the porous structure and the detailed structure of the hydrogel composite according to an embodiment of the present application Drawing. Referring to (a) of FIG. 6, it can be seen that the hydrogel (white) and the one-dimensional nano-chain structure (red) are not uniformly distributed but aggregated. Referring to FIG. 6 (b), the hydrogel (white) ) And the one-dimensional nano-chain structure (red) are uniformly dispersed. The hydrogel wrapped on the surface of the one-dimensional nano-chain structure can be expected to have excellent steric hindrance of the one-dimensional nano-chain structure and excellent chemical compatibility of the hydrogel.

7 is a mechanical strength measurement photograph and mechanical strength measurement result graph of the hydrogel composite according to an embodiment of the present application. Referring to FIG. 7, the mechanical strength and the strain increased as the concentration increased to 0.01% of the concentration of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ). As the strength increases, the mechanical strength and strain decrease. It can be seen that the preferred concentration range of the one-dimensional nano-chain structure in the hydrogel composite according to the present application is 0.01%.

8 is a graph of the mechanical strength measurement results of the hydrogel composite according to an embodiment of the present application. Referring to FIG. 8, the maximum tensile strength of the hydrogel composite at the optimum concentration (0.01%) of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) was 27.6 kPa, which was about 367% higher than the maximum tensile strength of the pure hydrogel. . In addition, the maximum modulus of elasticity of the hydrogel composite was 54.8 kPa at the optimum concentration (0.01%) of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ), which is about 378% higher than that of the pure hydrogel. In addition, the maximum toughness of the hydrogel composite at the optimal concentration (0.01%) of the one-dimensional nano-chain structure (Mo ₃ Se ₃ ⁻ ) obtained by integrating the area of the tensile stress-strain curve is 26.9 kJ / m ³ , which is the maximum of pure hydrogels. About 868% better than toughness.

9 is a scanning electron microscope (SEM) image showing a change in the porous structure according to the concentration of the one-dimensional nano-chain structure of the hydrogel composite according to an embodiment of the present application. Referring to Figure 9, the hydrogel composite according to an embodiment of the present application was prepared in the concentration of 0.003 wt%, 0.01 wt% and 0.05 wt% of the one-dimensional nano-chain structure, respectively, the concentration of the one-dimensional nano-chain structure is 0.003 wt% , 0.01 wt% hydrogel complexes have a continuous fiber 3D network structure with no intertwining one-dimensional nano-chain structures separated from the gelatin hydrogel matrix as in pure gelatin hydrogels, so that one-dimensional nano-chains wrapped with gelatin polymers The structure has a uniform porous structure in the hydrogel. On the other hand, the hydrogel complex having a concentration of 0.05 wt% of the one-dimensional nano-chain structure has a phase separation between the one-dimensional nano-chain structure wrapped with the gelatin polymer and the hydrogel like the hydrogel composite without the one-dimensional nano-chain structure wrapped with the gelatin polymer. Occurred.

10 (a) to (d) is a graph of strength improvement of the hydrogel composite according to the Examples and Comparative Examples of the present application. Referring to Figures 10 (a) to (d), the maximum tensile strength, the maximum modulus of elasticity and the maximum toughness of the hydrogel composite according to an embodiment of the present application is 367%, 378% and 868%, respectively, the most conventional hydro Larger than the gel complex. Simultaneous increase in tensile strength and tensile strain of the hydrogel composite according to an embodiment of the present application can significantly improve toughness, unlike the hydrogel composite of the prior art. It can be seen that the inorganic properties, dimensions, flexible mechanical properties, large surface area and ability to interact with biomolecules are ideal nanomaterials to enhance the mechanical properties of natural hydrogels.

The above description of the present application is intended for illustration, and it will be understood by those skilled in the art that the present invention may be easily modified in other specific forms without changing the technical spirit or essential features of the present application. Therefore, it should be understood that the embodiments described above are exemplary in all respects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present application is indicated by the following claims rather than the above detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present application.

Claims (16)

In a hydrogel composite, wherein the one-dimensional nano chain structure wrapped by a polymer is dispersed on a hydrogel substrate,
There is no dangling bond of the side of the one-dimensional nano-chain structure,
Hydrogel complex.
The method of claim 1,
The one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I 8, TaSe 3, TiS 3, NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof Will contain a material selected from the group, hydrogel complex.
The method of claim 1,
The polymer comprises a amine group, hydrogel composite.
The method of claim 1,
Wherein the polymer comprises a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen and combinations thereof.
The method of claim 1,
The hydrogel base is a hydrogel complex, comprising a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen and combinations thereof.
The method of claim 1,
The one-dimensional nano-chain structure will have a diameter of less than 10 nm, hydrogel composite.
delete Wrapping the one-dimensional nano-chain structure with the polymer; And
Dispersing the one-dimensional nano-chain structure wrapped with the polymer on a hydrogel substrate;
Including,
There is no dangling bond of the side of the one-dimensional nano-chain structure,
Method for producing a hydrogel composite.
The method of claim 8,
The one-dimensional nano-chain structure is ^{_{Mo 3 Se 3 -, Mo 6}} S 3 I 6, Nb 2 Se 9, V 2 Se 9, VS 4, Nb x V y Se 9, Nb 3 I 8, TaSe 3, TiS 3, NaNb ₂ PS ₁₀ , LiMo ₃ Se ₃ , Ta ₂ Se ₈ I, Ni ₈ Bi ₈ SI ₂ , Ni ₈ Bi ₈ SI, InMo ₃ Se ₃ , Sb ₂ Se ₃ , Sb ₂ S ₃ and combinations thereof It comprises a material selected from the group, method for producing a hydrogel composite.
The method of claim 8,
The polymer is a method for producing a hydrogel composite, comprising an amine group.
The method of claim 8,
Wherein the polymer comprises a natural polymer selected from the group consisting of gelatin, chitosan, hyaluronic acid, collagen, and combinations thereof.
The method of claim 8,
The hydrogel substrate is gelatin, chitosan, hyaluronic acid, collagen and a natural polymer selected from the group consisting of a combination thereof, the method of producing a hydrogel composite.
The method of claim 8,
The concentration of the one-dimensional nano-chain structure is 0.003 wt% to 0.05 wt%, the method for producing a hydrogel composite.
The method of claim 10,
In the step of wrapping the one-dimensional nano-chain structure with a polymer, it is uniformly wrapped by the chemical bond between the amine group and the one-dimensional nano-chain structure of the polymer, a method for producing a hydrogel composite.
delete The method of claim 8,
The one-dimensional nano-chain structure has a diameter of 10 nm or less, a method for producing a hydrogel composite.

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