KR102048436B1 - Composition for Improving Skin Wrinkles Using Using Ginsenoside Compound K and a Bark Extract of Ulmus davidiana - Google Patents
Composition for Improving Skin Wrinkles Using Using Ginsenoside Compound K and a Bark Extract of Ulmus davidiana Download PDFInfo
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- KR102048436B1 KR102048436B1 KR1020190045430A KR20190045430A KR102048436B1 KR 102048436 B1 KR102048436 B1 KR 102048436B1 KR 1020190045430 A KR1020190045430 A KR 1020190045430A KR 20190045430 A KR20190045430 A KR 20190045430A KR 102048436 B1 KR102048436 B1 KR 102048436B1
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Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
Description
본 발명은 진세노사이드 화합물 K(이하 "CK")와 유근피 추출물을 이용한 피부 주름 개선용 조성물 및 피부 보습용 조성물에 관한 것이다.The present invention relates to a composition for improving skin wrinkles and a composition for moisturizing skin using a ginsenoside compound K (hereinafter referred to as "CK") and a root skin extract.
피부는 인체의 약 16%를 차지하고 있으며, 외부환경과 직접적으로 접해 있어 온도, 습도 및 자외선 등과 같은 외부 유해인자들로부터 인체를 보호하는 중요한 역할을 하고 있다. 피부는 각질 아래 표피, 진피, 피하조직으로 구성되어 있다. 표피는 주로 케라틴으로 되어 있는 케라티노사이트(keratinocytes), 멜라닌을 생성하고 분비하는 멜라닌 세포(melanocytes), 랑게르한스 세포(langerhans cells) 등의 면역세포 그리고 지각관련세포 (Merkel's copuscles)로 구성되는 얇은 보호층으로 외부자극과 병원균의 침입을 방지하고 체온조절, 수분과 지질 성분 유지 작용을 한다. 진피는 표피 아래에 있는 결합조직으로 대부분 세포외 간질(extracellular matrix)이라 불리는 거대 분자의 망상 구조로 구성되어 있다. 이 세포외 간질은 섬유아세포에서 만들어지며, 콜라겐, 엘라스틴 등의 섬유상 단백질과 히알루론산 등의 다당체로 이루어져 있다. Skin accounts for about 16% of the human body and is directly in contact with the external environment and plays an important role in protecting the human body from external harmful factors such as temperature, humidity and ultraviolet rays. The skin consists of the epidermis, dermis and subcutaneous tissue under the keratin. The epidermis is a thin protective layer consisting mainly of keratinocytes, primarily keratin, melanocytes, melanocytes that produce and secrete melanin, and Langerhans cells, as well as Merkel's copuscles. It prevents external stimulation and invasion of pathogens, controls body temperature, and maintains moisture and lipid components. The dermis is the connective tissue beneath the epidermis and is composed mostly of a network of macromolecules called extracellular matrix. This extracellular epilepsy is made from fibroblasts and consists of fibrous proteins such as collagen and elastin and polysaccharides such as hyaluronic acid.
나이가 들어감에 따라 각종 오염물질, 강한 자외선, 스트레스 및 영양결핍 등으로 인해 피부 세포들이 손상을 입게 되고, 세포 증식이 원활하게 되지 않아 피부에 주름, 탄력 손실 및 각질화 등이 발생한다(Gilchrest B.A., J. Am. Acad. Dermatol, 21:610, 1989). 이러한 피부의 노화는 내인성 노화와 외인성 노화로 분류된다. 내인성 노화는 나이가 들어 피부의 생리적 기능이 저하되어 자연적으로 나타나는 노화 현상으로 탄력이 감소하고 피부 결이 거칠어지고 깊은 주름이 생기며 색소가 침착되는 특징이 있다. 외인성 노화는 자외선, 활성산소종 및 스트레스 등의 외부 요인에 의해 발생하는 노화를 말한다. 상기의 다양한 요인에 의하여 피부노화 현상이 진행되면 각질형성세포 및 섬유아세포의 분열 감소, 히알루론산 감소, 콜라겐 합성 감소, MMP 생성의 증가, 멜라닌 생성의 신호 전달 증가 등이 발생하여 보습 저하, 주름 생성 및 피부 탄력 감소 등의 현상이 나타난다. As we age, skin cells are damaged by various contaminants, strong ultraviolet rays, stress and malnutrition, and cell proliferation is not smooth and wrinkles, loss of elasticity and keratinization occur on the skin (Gilchrest BA, J. Am. Acad. Dermatol, 21: 610, 1989). The aging of the skin is classified into endogenous aging and exogenous aging. Endogenous aging is a aging phenomenon that occurs naturally as the physiological function of the skin decreases with age, and the elasticity decreases, the skin texture becomes rough, deep wrinkles occur, and pigments are deposited. Exogenous aging refers to aging caused by external factors such as ultraviolet light, reactive oxygen species and stress. As skin aging progresses due to the various factors described above, decreased keratinocytes and fibroblasts divide, decrease hyaluronic acid, decrease collagen synthesis, increase MMP production, increase signal transmission of melanin, etc. And a decrease in skin elasticity.
콜라겐은 피부 수분을 유지하고 피부 유연성과 탄력을 유지하는 데 가장 중요한 단백질로 진피층의 90%를 차지하고 있으며(J Am Acad Dermatol, 17(4):610-613, 2001) 피부의 강도와 장력을 부여하여 외부의 자극으로부터 피부를 보호하는 역할을 한다. 콜라겐은 섬유아세포에 의해 합성되며 콜라겐나아제(collagenase)와 엘라스티나아제(elastinase에 의해 분해된다. 나이가 들거나 자외선 등에 노출되면 섬유아세포의 작용과 세포 수가 감소하여 콜라겐의 합성량이 줄어들고 콜라겐을 분해하는 콜라겐나아제(collagenase)와 엘라스티나아제(elastinase)의 작용이 증가하여 피부 수분이 손실되고 피부 유연성과 탄력이 감소하게 된다. Collagen is the most important protein for maintaining skin moisture, maintaining skin flexibility and elasticity, making up 90% of the dermis (J Am Acad Dermatol, 17 (4): 610-613, 2001). It protects the skin from external stimuli. Collagen is synthesized by fibroblasts and is broken down by collagenase and elastinase.As they age or are exposed to ultraviolet light, the activity and cell count of fibroblasts decrease, which reduces collagen synthesis and breaks down collagen. Collagenase and elastinase increases the action of the skin moisture is lost and skin flexibility and elasticity is reduced.
외인성 노화를 일으키는 가장 중요한 요인으로 자외선이 있으며, 자외선에 의한 외인성 노화현상을 광노화라고 한다(Lee JN et al., J Soc Cosmet Scientists Korea 32:227-231, 2006). 피부가 자외선에 지속적으로 노출되면 피부에 유해한 대사과정이 일어나게 되며 활성산소가 증가한다(Rittie L and Fisher GJ. Ageing Res. Rev. 1:705-720. 2002.). 활성산소는 MMP9, MMP2 등 MMPs(기질분해 효소, matrix metalloproteinase) 등 다양한 종류의 콜라게나제의 발현 및 활성증가를 유도하여 불규칙적인 콜라겐이 형성되는데, 이로 인해 피부 표면 이 거칠고 비대해 지며 깊은 주름이 생기게 되는 것으로 알려져 있다(Fisher GJ et al., J Invest Dermatol 117:219-226, 2001; Jean LB. Am J Med 8:S99-S103, 1995; Laure RG and Fisher J. Ageing Res Rev 1:705-720, 2002). UV is the most important factor that causes exogenous aging, and exogenous aging caused by UV is called photoaging (Lee JN et al., J Soc Cosmet Scientists Korea 32: 227-231, 2006). Persistent exposure to UV light results in harmful metabolic processes and increased free radicals (Rittie L and Fisher GJ. Ageing Res. Rev. 1: 705-720. 2002.). Free radicals induce the expression and activity of various kinds of collagenase such as MMPs (matrix metalloproteinases) such as MMP9 and MMP2, resulting in the formation of irregular collagen, which makes the skin surface rough and hypertrophy and deep wrinkles (Fisher GJ et al., J Invest Dermatol 117: 219-226, 2001; Jean LB. Am J Med 8: S99-S103, 1995; Laure RG and Fisher J. Ageing Res Rev 1: 705- 720, 2002).
현재 피부 주름형성을 억제하는 물질로는 레티노산과 레티놀(Simon C et al., J Invest Dermatol 98:248-260, 1992; Elaine S et al., J Invest Dermatol 96:975-978, 1991)의 효과가 입증되어 있고, dehydroepiandrosterone(Shin MH et al., J Invest Dermatol 124:315-323, 2005), 인삼에서 추출한 ginsenoside Rg3(Kim SW et al., J Soc Cosmet Scientists Korea 30:221-225, 2004), 플라보노이드(Francesco B et al., Int J Pharm 145:87-94, 1996), 팥배나무 추출물(한국 등록특허 제101008833호), 연교 추출물(한국 등록특허 제100825450호) 등 다양한 물질의 주름 개선 및 피부 보호효과가 탐색되었다. 그러나 일부 물질들은 안정성이 낮거나 피부 자극을 일으켜 안전성에 문제가 있기 때문에 사용에 제한이 있다. 이에 따라 우수한 주름개선 활성 효과와 안전성 및 안정성을 지닌 물질의 탐색이 지속되고 있다.The effects of retinoic acid and retinol (Simon C et al., J Invest Dermatol 98: 248-260, 1992; Elaine S et al., J Invest Dermatol 96: 975-978, 1991) Dehydroepiandrosterone (Shin MH et al., J Invest Dermatol 124: 315-323, 2005), ginsenoside Rg3 from Ginseng (Kim SW et al., J Soc Cosmet Scientists Korea 30: 221-225, 2004) , Flavonoids (Francesco B et al., Int J Pharm 145: 87-94, 1996), red bean pear extract (Korean Patent No. 101008833), duct bridge extract (Korean Patent No. 100825450) Skin protection was explored. However, some substances have limited use because of low stability or skin irritation, which may cause safety problems. Accordingly, the search for a material having excellent anti-wrinkle activity, safety and stability continues.
본 발명은 CK 단독 그리고 유근피 추출물 단독의 피부 주름 개선 활성과 이들의 혼합에 의한 피부 주름 개선 활성 등을 개시한다.The present invention discloses the skin wrinkle improvement activity of CK alone and the root extract alone and skin wrinkle improvement activity by mixing them.
본 발명의 목적은 CK와 유근피 추출물을 이용한 피부 주름 개선용 조성물을 제공하는 데 있다.An object of the present invention to provide a composition for improving skin wrinkles using the extract CK and root skin.
본 발명의 다른 목적이나 구체적인 목적은 이하에서 제시될 것이다.Other and specific objects of the present invention will be presented below.
본 발명자들은 아래의 실시예에서 확인할 수 있듯이, CK와 유근피 추출물 각각이 단독으로 콜라겐 생성 촉진 활성을 가질 뿐만 아니라 이들을 혼합하여 처리할 경우에는 각 단독의 콜라겐 생성 촉진 활성보다 더 높은 콜라겐 생성 촉진 활성을 가짐을 확인하였으며, 또 이 혼합물이 인체적용시험에 있어서도 뚜렷한 피부 보습 효과를 가짐을 확인하였다. As can be seen in the examples below, the inventors of the present invention show that each of CK and rhizome extracts has not only collagen production promoting activity alone, but when they are mixed and treated, collagen production promoting activity is higher than that of each alone. It was confirmed that the mixture had a distinct skin moisturizing effect even in the human application test.
본 발명은 이러한 실험 결과에 기초하여 제공되는 것으로, 본 발명의 피부 주름 개선용 조성물과 피부 보습용 조성물은 CK, 유근피 추출물 또는 이들의 혼합물을 유효성분으로 포함함을 특징으로 한다.The present invention is provided on the basis of the experimental results, the composition for improving skin wrinkles and the skin moisturizing composition of the present invention is characterized in that it comprises CK, dermis root extract or a mixture thereof as an active ingredient.
본 명세서에서, 상기 "유근피 추출물"은 추출 대상인 유근피 즉 느릅나무(Ulmus davidiana var. japonica Nakai)의 껍질을 물, 탄소수 1 내지 4의 저급 알콜(메탄올, 에탄올, 부탄올 등), 메틸렌클로라이드, 에틸렌, 아세톤, 헥산, 에테르, 클로로포름, 에틸아세테이트, 부틸아세테이트, N,N-디메틸포름아미드(DMF), 디메틸설폭사이드(DMSO), 1,3-부틸렌글리콜, 프로필렌글리콜 또는 이들의 혼합 용매를 사용하여 침출하여 얻어진 추출물, 이산화탄소, 펜탄 등 초임계 추출 용매를 사용하여 얻어진 추출물 또는 그 추출물을 분획하여 얻어진 분획물을 의미하며, 추출 방법은 활성물질의 극성, 추출 정도, 보존 정도를 고려하여 냉침, 환류, 가온, 초음파 방사, 초임계 추출 등 임의의 방법을 적용할 수 있다. 분획된 추출물의 경우 추출물을 특정 용매에 현탁시킨 후 극성이 다른 용매와 혼합·정치시켜 얻은 분획물, 상기 조추출물을 실리카겔 등이 충진된 칼럼에 흡착시킨 후 소수성 용매, 친수성 용매 또는 이들의 혼합 용매를 이동상으로 하여 얻은 분획물을 포함하는 의미이다. 또한 상기 추출물의 의미에는 동결건조, 진공건조, 열풍건조, 분무건조 등의 방식으로 추출 용매가 제거된 농축된 액상의 추출물 또는 고형상의 추출물이 포함된다. 바람직하게는 추출용매로서 물, 에탄올 또는 이들의 혼합 용매를 사용하여 얻어진 추출물, 더 바람직하게는 추출용매로서 물과 에탄올의 혼합 용매를 사용하여 얻어진 추출물을 의미한다.In the present specification, the "derived bark extract" refers to the bark of the bark of the root of the extract, namely, elm ( Ulmus davidiana var. Japonica Nakai), water, lower alcohols having 1 to 4 carbon atoms (methanol, ethanol, butanol, etc.), methylene chloride, ethylene, Using acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol or a mixed solvent thereof An extract obtained by leaching, extract obtained by using a supercritical extraction solvent such as carbon dioxide, pentane, or a fraction obtained by fractionating the extract.The extraction method is cold extraction, reflux, Arbitrary methods, such as heating, ultrasonic radiation, supercritical extraction, can be applied. In the case of fractionated extract, the fraction obtained by suspending the extract in a specific solvent, mixing and standing with a solvent having a different polarity, adsorbing the crude extract on a column filled with silica gel, etc., and then using a hydrophobic solvent, a hydrophilic solvent, or a mixed solvent thereof It is meant to include fractions obtained by mobile phase. In addition, the meaning of the extract includes a concentrated liquid extract or solid extract in which the extraction solvent is removed in a manner such as freeze drying, vacuum drying, hot air drying, spray drying, and the like. Preferably it refers to an extract obtained by using water, ethanol or a mixed solvent thereof as the extraction solvent, more preferably an extract obtained by using a mixed solvent of water and ethanol as the extraction solvent.
또 본 명세서에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In addition, the term "active ingredient" as used herein means a component that can exhibit the desired activity alone or in combination with a carrier that is not active itself.
또 본 명세서에서, "피부 주름 개선"이란 피부 주름의 증상의 완화, 그러한 증상의 발현 억제, 발현 지연, 발현 제거를 포함하는 의미이다. In addition, in this specification, "skin improvement" means the alleviation of the symptoms of skin wrinkles, suppressing the expression of such symptoms, delaying the expression, and removing the expression.
본 발명의 조성물은 유효성분 이외에, 피부 관련 활성을 보강·추가하기 위하여 당업계에 공지된 피부 미백 성분, 피부 주름 개선 성분, 자외선 보호 성분, 피부 보습 성분 등을 포함하여 제조될 수 있다. 구체적으로 피부 미백 성분으로서는 알부틴, 나이아신아마이드, 아스코빌글루코사이드, 알파-비사보롤, 유용성 감초 추출물(Oil Soluble Licorice(Glycyrrhiza) Extract) 등을 들 수 있으며, 또 피부 주름 개선 성분으로서는 레티놀, 레티닐팔미테이트, 아데노신, 폴리에톡실레이티드아마이드 등을 들 수 있고, 자외선 보호 성분으로서는 드로메트리졸, 드로메트리졸트리실록산, 디갈로일트리올리에이트, 디메치코디에칠벤잘말로네이트, 디에칠헥실부타미도트리아존, 소나무 껍질 추출물 등의 복합물, 포스파티딜세린, 핑거루트 추출 분말, 홍삼과 산수유 등의 복합 추출물 등을 들 수 있다. 또 보습 성분으로서는 AP 콜라겐 효소 분해 펩타이드, Collactive 콜라겐 펩타이드, N-아세틸글루코사민, 곤약 감자 추출물, 민들레 등의 복합 추출물, 쌀겨 추출물, 옥수수 배아 추출물, 저분자 콜라겐 펩타이드, 지초 추출 분말, 포스파티딜세린, 히알루론산 등을 들 수 있다. 여타의 피부 미백 성분, 주름 개선 성분, 자외선 보호 성분, 피부 보습 성분들에 대해서는 화장품법에 따른 기능성화장품공전(식약처고시 "기능성화장품 기준 및 시험방법"), 건강기능식품에관한법률의 건강기능식품공전(식약처고시 "건강기능식품 기준 및 규격)을 참조할 수 있다. 이러한 성분들은 본 발명의 조성물에 그 유효성분과 함께 하나 이상 포함될 수 있다.In addition to the active ingredient, the composition of the present invention may be prepared to include skin whitening ingredients, skin wrinkle improvement ingredients, UV protection ingredients, skin moisturizing ingredients and the like known in the art to enhance and add skin related activities. Specifically, skin whitening ingredients include arbutin, niacinamide, ascorbyl glucoside, alpha-bisabolol, oil soluble licorice (Glycyrrhiza) extract, and the like, and skin wrinkle improvement ingredients such as retinol and retinyl palmi Tate, adenosine, a polyethoxylated amide, etc., As a ultraviolet protection component, dromethazole, a dromethazole trisiloxane, the digaloyl tri oleate, the dimethco diethyl benzal malonate, the diehexyl buty Butami Complexes such as dotriazone, pine bark extract, phosphatidylserine, finger root extract powder, complex extracts such as red ginseng and cornus milk. The moisturizing component includes AP collagen degrading peptide, Collactive collagen peptide, N-acetylglucosamine, konjac potato extract, dandelion and other complex extracts, rice bran extract, corn germ extract, low molecular collagen peptide, herbal extract powder, phosphatidylserine, hyaluronic acid, etc. Can be mentioned. For other skin whitening ingredients, wrinkle improvement ingredients, UV protection ingredients, and skin moisturizing ingredients, the functional cosmetics code according to the Cosmetics Act ("Notice of functional cosmetics standards and test methods" of the KFDA) and the health functional foods of the Act on Health Functional Foods Reference may be made to the Code of Ethics (NFDA standards and standards). One or more of these ingredients may be included in the composition of the present invention together with the active ingredient.
본 발명의 조성물에서 그 유효성분은 그것이 피부 주름 개선 활성, 피부 보습 활성을 나타낼 수 있는 한, 용도, 제형, 배합 목적 등에 따라 임의의 양(유효량)으로 포함될 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 20.0 중량 % 범위 내에서 결정될 것이다. 여기서 "유효량"이란 그 적용 대상인 사람에게 의료 전문가 등의 제언에 의한 투여 기간 동안 본 발명의 조성물이 투여될 때, 피부 주름 개선 효과, 피부 보습 효과 등 의도한 의료적·약리학적 효과를 나타낼 수 있는, 본 발명의 조성물에 포함되는 유효성분의 양을 말한다. 이러한 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다. The active ingredient in the composition of the present invention may be included in any amount (effective amount) according to the use, formulation, formulation purpose, etc., as long as it can exhibit skin wrinkle improving activity, skin moisturizing activity, and the usual effective amount is the total weight of the composition. It will be determined in the range of 0.001% to 20.0% by weight based on Here, the term "effective amount" means that when the composition of the present invention is administered to a person subject to the application during the administration period according to the suggestion of a medical professional, it may exhibit an intended medical and pharmacological effect such as skin wrinkle improvement effect and skin moisturizing effect. , Refers to the amount of the active ingredient included in the composition of the present invention. Such effective amounts can be determined experimentally within the range of ordinary skill in the art.
본 발명의 조성물은 구체적인 양태에 있어서, 화장료 조성물로 파악할 수 있다.The composition of this invention can be grasped | ascertained as a cosmetic composition in a specific aspect.
본 발명의 조성물이 화장료 조성물로 파악될 경우에도 그 화장료 조성물은 그 용도상, 법률상 임의의 제품 구분을 띨 수 있으며, 구체적으로 피부 미백 등의 용도를 가진 기능성 화장품, 비기능성 일반 화장품 등일 수 있다. 제품 형태에 있어서도 임의의 제품 형태를 띨 수 있는데, 구체적으로 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 스프레이 등으로 제형화될 수 있다. 구체적인 제품 형태에 있어서는 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형 등일 수 있다.Even when the composition of the present invention is identified as a cosmetic composition, the cosmetic composition may be classified into any product according to its use and law. Specifically, the cosmetic composition may be a functional cosmetic having a use such as skin whitening, a non-functional general cosmetic, or the like. . The product form can also be in any product form, specifically solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, waxes It can be formulated into a foundation, spray, and the like. In a specific product form, it may be a softening lotion, a nourishing lotion, a nourishing cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder formulation.
본 발명의 화장료 조성물은 그 유효성분 이외에 화장료 조성물에 통상적으로 이용되는 성분들, 예컨대, 안정화제, 용해화제, 계면활성제, 비타민, 색소 및 항료와 같은 통상적인 보조제, 및 담체를 포함할 수 있다. The cosmetic composition of the present invention may include, in addition to the active ingredient, components conventionally used in the cosmetic composition, for example, conventional adjuvants such as stabilizers, solubilizers, surfactants, vitamins, pigments and pharmaceuticals, and carriers.
본 발명의 제형이 페이스트, 크림 또는 젤인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜, 소르비탄의 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol, fatty acid ester of sorbitan and the like can be used.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르, 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 등이 이용될 수 있다.When the formulation of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, polyoxyethylene sorbitan ester, and microcrystals are used as carrier components. Castle cellulose, aluminum metahydroxy, bentonite, agar and the like can be used.
본 발명의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
본 발명의 화장료 조성물은 피부 주름 개선 활성 등을 나타내는 그 유효성분을 포함하는 것을 제외하고는 당업계에 통상적으로 행하여지는 화장료 조성물의 제조방법에 따라 제조할 수 있다.The cosmetic composition of the present invention can be prepared according to the manufacturing method of the cosmetic composition usually carried out in the art, except for including the active ingredient exhibiting skin wrinkle improvement activity and the like.
본 발명의 조성물은 다른 구체적인 양태에 있어서, 식품 조성물로 파악할 수 있다.The composition of this invention can be grasped | ascertained as a food composition in another specific aspect.
본 발명의 식품 조성물은 어떠한 형태로도 제조될 수 있으며, 예컨대 차, 쥬스, 탄산음료, 이온음료 등의 음료류, 우유, 요구루트 등의 가공 유류, 껌류, 떡, 한과, 빵, 과자, 면 등의 식품류, 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 바 등의 건강기능식품 제제류 등으로 제조될 수 있다. 또 본 발명의 식품 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 건강기능식품에관한법률에 따른 건강기능식품이거나, 식품위생법의 식품공전(식약처 고시, 식품의 기준 및 규격)상 각 식품유형에 따른 두유류, 발효음료류, 특수용도식품 등일 수 있다.The food composition of the present invention may be prepared in any form, for example, beverages such as tea, juice, carbonated beverages, ionic beverages, processed oils such as milk, yogurt, gums, rice cakes, sweets, bread, sweets, noodles, and the like. It can be prepared as a dietary supplement, such as foods, tablets, capsules, pills, granules, liquid, powder, flaky, paste, syrup, gel, jelly, bar. In addition, the food composition of the present invention can distinguish any product as long as it conforms to the enforcement regulations at the time of manufacture and distribution in the legal and functional divisions. For example, it may be a health functional food according to the Act on Health Functional Foods, or soy milk, fermented beverages, special purpose foods, etc. according to each food type in the Food Code of the Food Sanitation Act (KFDA notice, standards and standards of food).
본 발명의 식품 조성물에는 그 유효성분 이외에 식품첨가물이 포함될 수 있다. 식품첨가물은 일반적으로 식품을 제조, 가공 또는 보존함에 있어 식품에 첨가되어 혼합되거나 침윤되는 물질로서 이해되는데, 식품과 함께 매일 그리고 장기간 복용되므로 그 안전성이 보장되어야 한다. 식품위생법에 따른 식품첨가물공전(식약처 고시, 식품첨가물 기준 및 규격)에는 안전성이 보장된 식품첨가물이 화학적 합성품, 천연 첨가물, 혼합 제제류로 구분하여 한정적으로 규정되어 있다. The food composition of the present invention may include food additives in addition to the active ingredient. Food additives are generally understood as substances that are added to, mixed with, or infiltrated in the manufacture, processing, or preservation of foods, and because they are taken daily with food for a long time, their safety should be ensured. The Food Additives Code of the Food Sanitation Act (KFDA Notification, Food Additives Standards and Standards) defines the food additives that are guaranteed to be safe by dividing them into chemical synthetics, natural additives, and mixed preparations.
이들 식품첨가물은 기능적 측면에 있어서는 감미제, 풍미제, 보존제, 유화제, 산미료, 점증제 등으로 구분될 수 있다. These food additives may be divided into sweeteners, flavors, preservatives, emulsifiers, acidulants, thickeners, and the like in terms of their functionalities.
감미제는 식품이 적당한 단맛을 나게 하는 양으로 사용될 수 있으며, 천연의 것이거나 합성된 것일 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. Sweeteners may be used in amounts that give the food a suitable sweet taste, and may be natural or synthetic. Preferably, a natural sweetener is used. Examples of the natural sweetener include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수도 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제는 에스테르, 알콜, 알데하이드, 테르펜 등이 이용될 수 있다. Flavoring agents can be used to enhance the taste or aroma, both natural and synthetic. It is the case of using a natural thing preferably. In addition to flavors, the use of natural ones can be combined with nutritional purposes. The natural flavor may be obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or may be obtained from green tea leaves, round leaves, jujube leaves, cinnamon, chrysanthemum leaves, jasmine and the like. In addition, ginseng (red ginseng), bamboo shoots, aloe vera, ginkgo, etc. may be used. Natural flavors can be liquid concentrates or solid extracts. In some cases, synthetic flavoring agents may be used, and synthetic flavoring agents may include esters, alcohols, aldehydes, terpenes, and the like.
보존제로서는 소듐 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등이 사용될 수 있고, 또 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등을 들 수 있으며, 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등이 사용될 수 있다. 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.Sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), etc. may be used as a preservative, and as an emulsifier, acacia gum, carboxymethylcellulose, xanthan gum, Pectin etc. can be mentioned, As acidic acid, acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, etc. can be used. The acidulant may be added so that the food composition is at an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to the purpose of enhancing the taste.
점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등이 사용될 수 있다.As the thickener, suspending implementers, sedimenting agents, gel formers, swelling agents and the like can be used.
본 발명의 식품 조성물은 전술한 바의 식품첨가물 이외에, 기능성과 영양성을 보충, 보강할 목적으로 당업계에 공지되고 식품첨가물로서 안정성이 보장된 생리활성 물질이나 미네랄류를 포함할 수 있다.In addition to the food additives described above, the food composition of the present invention may include a bioactive substance or minerals known in the art for the purpose of supplementing and reinforcing the functionality and nutritional properties and ensuring the stability as a food additive.
그러한 생리활성 물질로서는 녹차 등에 포함된 카테킨류, 비타민 B1, 비타민 C, 비타민 E, 비타민 B12 등의 비타민류, 토코페롤, 디벤조일티아민 등을 들 수 있으며, 미네랄류로서는 구연산 칼슘 등의 칼슘 제제, 스테아린산마그네슘 등의 마그네슘 제제, 구연산철 등의 철 제제, 염화 크롬, 요오드칼륨, 셀레늄, 게르마늄, 바나듐, 아연 등을 들 수 있다. Examples of such physiologically active substances include catechins, vitamin B1, vitamin C, vitamin E, vitamin B12 and the like, tocopherol, dibenzoylthiamine, and the like contained in green tea. Examples of the minerals include calcium preparations such as calcium citrate and magnesium stearate. Magnesium preparations such as iron, iron preparations such as iron citrate, chromium chloride, potassium iodine, selenium, germanium, vanadium, zinc and the like.
본 발명의 식품 조성물에는 전술한 바의 식품첨가물이 제품 유형에 따라 그 첨가 목적을 달성할 수 있는 적량으로 포함될 수 있다.In the food composition of the present invention, the food additive as described above may be included in an amount that can achieve the purpose of addition according to the product type.
본 발명의 식품 조성물에 포함될 수 있는 기타의 식품첨가물과 관련하여서는 식품공전이나 식품첨가물 공전을 참조할 수 있다.Regarding other food additives that may be included in the food composition of the present invention, reference may be made to food or food additives.
본 발명의 조성물은 구체적인 양태에 있어서, 약제학적 조성물로 파악할 수 있다. The composition of this invention can be understood as a pharmaceutical composition in a specific aspect.
본 발명의 약제학적 조성물은 유효성분 이외에 약제학적으로 허용되는 담체를 포함하여 당업계에 공지된 통상의 방법으로 투여 경로에 따라 경구용 제형 또는 비경구용 제형으로 제조될 수 있다. 여기서 "약제학적으로 허용되는" 의미는 유효성분의 활성을 억제하지 않으면서 적용(처방) 대상이 적응 가능한 이상의 독성을 지니지 않는다는 의미이다.The pharmaceutical compositions of the present invention may be prepared in oral or parenteral formulations according to the route of administration by conventional methods known in the art, including pharmaceutically acceptable carriers in addition to the active ingredient. "Pharmaceutically acceptable" here means that the subject of application (prescription) is not toxic as far as adaptable without inhibiting the activity of the active ingredient.
본 발명의 약제학적 조성물이 경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 현탁액, 웨이퍼 등의 제형으로 제조될 수 있다. 이때 약제학적으로 허용되는 적합한 담체의 예로서는 락토스, 글루코스, 슈크로스, 덱스트로스, 솔비톨, 만니톨, 자일리톨 등의 당류, 옥수수 전분, 감자 전분, 밀 전분 등의 전분류, 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 나트륨 카르복시메틸셀룰로오스, 하이드록시프로필메틸셀룰로오스 등의 셀룰로오스류, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 마그네슘 스테아레이트, 광물유, 맥아, 젤라틴, 탈크, 폴리올, 식물성유 등을 들 수 있다. 제제화활 경우 필요에 따라 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 및/또는 부형제를 포함하여 제제화할 수 있다.When the pharmaceutical composition of the present invention is prepared in an oral dosage form, powders, granules, tablets, pills, dragees, capsules, solutions, gels, syrups, suspensions, wafers according to methods known in the art with suitable carriers It may be prepared in a formulation such as. Examples of suitable pharmaceutically acceptable carriers include lactose, glucose, sucrose, dextrose, sugars such as sorbitol, mannitol, xylitol, starch such as corn starch, potato starch, wheat starch, cellulose, methylcellulose, ethylcellulose, Celluloses such as sodium carboxymethylcellulose, hydroxypropylmethylcellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, mineral oil, malt, gelatin, talc, polyol, vegetable Yu etc. can be mentioned. If formulated, it may be formulated to include diluents and / or excipients, such as fillers, extenders, binders, wetting agents, disintegrants, surfactants, if necessary.
본 발명의 약제학적 조성물이 비경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 주사제, 경피 투여제, 비강 흡입제 및 좌제의 형태로 제제화될 수 있다. 주사제로 제제화활 경우 적합한 담체로서는 멸균수, 에탄올, 글리세롤이나 프로필렌 글리콜 등의 폴리올 또는 이들의 혼합물을 들수 있으며, 바람직하게는 링거 용액, 트리에탄올 아민이 함유된 PBS(phosphate buffered saline)나 주사용 멸균수, 5% 덱스트로스 같은 등장 용액 등을 사용할 수 있다. 경피 투여제로 제제화할 경우 연고제, 크림제, 로션제, 겔제, 외용액제, 파스타제, 리니멘트제, 에어롤제 등의 형태로 제제화될 수 있다. 비강 흡입제의 경우 디클로로플루오로메탄, 트리클로로플루오로메탄, 디클로로테트라플루오로에탄, 이산화탄소 등의 적합한 추진제를 사용하여 에어로졸 스프레이 형태로 제제화될 수 있으며, 좌제의 기제로는 위텝솔(witepsol), 트윈(tween) 61, 폴리에틸렌글리콜류, 카카오지, 라우린지, 폴리옥시에틸렌 소르비탄 지방산 에스테르류, 폴리옥시에틸렌 스테아레이트류, 소르비탄 지방산 에스테르류 등이 사용될 수 있다.When the pharmaceutical compositions of the present invention are prepared in parenteral formulations, they may be formulated in the form of injections, transdermal administrations, nasal inhalants and suppositories with suitable carriers according to methods known in the art. When formulated as an injection, suitable carriers include sterile water, ethanol, polyols such as glycerol or propylene glycol, or mixtures thereof. Preferably, PBS (phosphate buffered saline) containing Ringer's solution or triethanol amine or sterile water for injection , Isotonic solutions such as 5% dextrose, and the like can be used. When formulated as a transdermal administration, it may be formulated in the form of an ointment, cream, lotion, gel, external solution, pasta, linen, aerosol and the like. Nasal inhalants can be formulated in the form of aerosol sprays using suitable propellants, such as dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide, etc. The suppository bases are witepsol, twin (tween) 61, polyethylene glycols, cacao butter, laurin paper, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearate, sorbitan fatty acid esters and the like can be used.
약제학적 조성물의 제제화와 관련하여서는 당업계에 공지되어 있으며, 구체적으로 문헌[Remington's Pharmaceutical Sciences(19th ed., 1995)] 등을 참조할 수 있다. 상기 문헌은 본 명세서의 일부로서 간주 된다.Regarding the formulation of pharmaceutical compositions, it is known in the art and specific reference may be made to Remington's Pharmaceutical Sciences (19th ed., 1995) and the like. The document is considered part of this specification.
본 발명의 약제학적 조성물의 바람직한 투여량은 환자의 상태, 체중, 성별, 연령, 환자의 중증도, 투여 경로에 따라 1일 0.001mg/kg ~ 10g/kg 범위, 바람직하게는 0.001mg/kg ~ 1g/kg 범위일 수 있다. 투여는 1일 1회 또는 수회로 나누어 이루어질 수 있다. 이러한 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 해석되어서는 아니 된다.Preferred dosages of the pharmaceutical compositions of the present invention range from 0.001 mg / kg to 10 g / kg per day, preferably 0.001 mg / kg to 1 g, depending on the condition, body weight, sex, age, severity of the patient and route of administration. It can range from / kg. Administration can be done once a day or divided into several times. Such dosage should not be construed as limiting the scope of the invention in any aspect.
전술한 바와 같이, 본 발명에 따르면 콜라겐 생성 촉진 활성을 가지는 CK와 유근피 추출물을 이용한 피부 주름 개선용 조성물과 피부 보습용 조성물을 제공할 수 있다. As described above, according to the present invention, it is possible to provide a composition for improving skin wrinkles and a composition for moisturizing the skin using CK and myofibril extract having collagen production promoting activity.
본 발명의 조성물은 화장품, 식품 또는 약품으로 제품화될 수 있다.The composition of the present invention can be commercialized into cosmetics, food or drugs.
도 1은 사람 섬유아세포를 이용한 CK 및/또는 유근피 추출물의 콜라겐 생성 촉진 활성의 실험 결과이다.
도 2는 CK와 유근피 혼합물이 인체적용시험에서 피부 보습 활성을 가짐을 보여주는 결과이다.1 is an experimental result of collagen production promoting activity of CK and / or root bark extract using human fibroblasts.
Figure 2 is a result showing that the CK and the roots of the skin mixture has a skin moisturizing activity in the human application test.
이하 본 발명을 실시예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples. However, the scope of the present invention is not limited to these examples.
<실시예 1> CK와 유근피 추출물의 콜라겐 생성 촉진 활성Example 1 Collagen Production Promoting Activity of CK and Rhizome Extracts
1. 시료의 준비1. Preparation of Sample
CK는 자체 생산·정제한 순도 30%의 것을 사용하였으며, 유근피 추출물은 유근피 건조 분말에 10배 중량의 80% 에탄올을 가하고 상온에서 24시간 추출한 후, 여과하여 추출 잔사를 제거하고, 그 여과액을 감압농축하고 동결건조하여 분말상으로 제조하여 실험에 사용하였다.CK was produced and purified with 30% purity, and the extract of Yugeun-pi was added 10 times of 80% ethanol to the dry powder of Yu-geun-pi and extracted at room temperature for 24 hours, and then filtered to remove the extraction residue. Concentrated under reduced pressure and lyophilized to prepare a powder to be used in the experiment.
2. 실험방법2. Experimental method
사람 섬유아세포를 10%의 FBS(fetal bovine serum, Hyclone)가 첨가된 DMEM(Dulbecco's Modified Eagle Medium.Hyclone)으로 37℃, 5% CO2 조건에서 배양하였다. Human fibroblasts were incubated at 37 ° C. and 5% CO 2 with DMEM (Dulbecco's Modified Eagle Medium.Hyclone) added with 10% FBS (fetal bovine serum, Hyclone).
24 웰 플레이트에 사람 섬유아세포를 1×105cell/well 밀도로 분주한 다음, 24시간 배양하였다. 배지를 버리고 시료(CK와 유근피 추출물 그리고 이들의 혼합물)를 100㎍/ml 농도로 함유한 배지로 갈아주고 24시간 더 배양하였다. 배양액 중에 생합성되어 유리된 콜라겐의 양을 procollagen type I C-peptide EIA kit(Takara, Japan)로 측정하다. Human fibroblasts were dispensed at 1 × 10 5 cell / well density in a 24-well plate and incubated for 24 hours. The medium was discarded and the sample (CK and root bark extract and mixture thereof) was changed to a medium containing 100 µg / ml and further incubated for 24 hours. The amount of collagen biosynthesized and released in the culture was measured by procollagen type I C-peptide EIA kit (Takara, Japan).
3. 실험 결과3. Experimental Results
결과를 시료 무처리군 대비 콜라겐 생성 정도에 대한 백분율로 하여 도 1에 나타내었다. 100㎍/ml 처리 농도에서 CK와 유근피 추출물 그리고 그 혼합물 모두 유의적으로 콜라겐 생성 촉진 활성을 보였으며(P<0.05), CK와 유근피 추출물의 6:4 내지 5:5 중량비의 혼합물(CK가 6 및 4 중량비임)의 콜라겐 생합성 촉진 활성이 우수하였다(A: CK 단독, B: CK와 유근피 추출물=8:2, C: CK와 유근피 추출물=6:4, D: CK와 유근피 추출물=5:5, E: CK와 유근피 추출물=4:6, F: CK와 유근피 추출물=2:8, G: 유근피 추출물 단독).The results are shown in FIG. 1 as a percentage of the degree of collagen production compared to the sample untreated group. At 100 μg / ml treatment concentration, both CK and root bark extract and its mixtures showed significant collagen production promoting activity ( P <0.05 ), and the mixture of CK and root bark extract in a 6: 4 to 5: 5 weight ratio (CK is 6 And 4 weight ratio) of the collagen biosynthesis promoting activity (A: CK alone, B: CK and root skin extract = 8: 2, C: CK and root skin extract = 6: 4, D: CK and root skin extract = 5: 5, E: CK and root bark extract = 4: 6, F: CK and root bark extract = 2: 8, G: root bark extract alone).
<실시예 2> CK와 유근피 추출물의 피부 보습 활성Example 2 Skin Moisturizing Activity of CK and Radix Cortex Extract
시료는 상기 콜라겐 생성 활성이 가장 우수한 CK와 유근피 추출물의 5:5 중량비의 혼합물이 3 중량%로 함유된 화장료 시료(로션, 실험군)와, CK가 3 중량%로 함유된 화장료 시료(로션, 대조군 1), 유근피 추출물이 3 중량%로 함유된 화장료 시료(로션, 대조군 2), 상기 CK와 유근피 추출물이 전혀 함유되지 아니한 화장료 시료(로션, 대조군 3)를 사용하였다. 상기 화장료 시료는 일반적으로 로션의 제조 방법에 따라 호모믹서로 균일하게 유화시키고 냉각시켜 제조하였으며, 상기 성분 이외에는 화장료 성분으로 일반적으로 널리 쓰이는 글리세린(4 중량%), 스테아릴알콜(6 중량%), 스쿠알렌(11 중량%), 스테아린산(2 중량%), 프로필렌글리콜모노스테아레이트(3 중량%), 프로필렌글리콜(4 중량%), 방부제(미량), 향료(미량), 정제수(잔량)를 포함하여 제조하였다. The sample is a cosmetic sample (lotion, experimental group) containing 3% by weight of a mixture of 5: 5 weight ratio of CK and the root extract of the best collagen production activity, and a cosmetic sample (lotion, control) containing 3% by weight of CK 1), a cosmetic sample (lotion, control 2) containing 3% by weight of the root skin extract, and a cosmetic sample (lotion, control 3) containing no CK and root root extract at all were used. The cosmetic sample was generally prepared by uniformly emulsifying and cooling with a homomixer according to the manufacturing method of the lotion, except for the above components, glycerin (4 wt%), stearyl alcohol (6 wt%), which are generally widely used as a cosmetic ingredient, Including squalene (11% by weight), stearic acid (2% by weight), propylene glycol monostearate (3% by weight), propylene glycol (4% by weight), preservative (trace), fragrance (trace), purified water (remaining amount) Prepared.
시험은 화장품 표시·광고 실증을 위한 시험방법 가이드라인(식약처, 2018)을 준하여 실시하였으며, 시료는 아침과 저녁 2회 도포하도록 하고, 평가는 공기의 이동이 없고 직사광선이 없으며 항온항습조건(20 ~ 24℃, 습도 40 ~ 60%)에서 이루어졌다. 피험자는 중도 탈락을 고려하여 40~50세 남녀 24명으로 하였으며, 시험 기간은 4주로 하고 피부수분함유도를 수분측정기인 Corneometer®를 이용하여 측정하였다. 결과를 도포 전 측정값 기준 백분율로 하여 1주, 2주, 3주, 4주차에 피부수분 증가율로 도 2에 나타내었다. The test was conducted in accordance with the test method guideline (KFDA, 2018) for the demonstration of cosmetics labeling and advertisement.The sample was applied twice a morning and evening, and the evaluation was carried out without air movement, no direct sunlight, and constant temperature and humidity conditions (20). ˜24 ° C., humidity 40-60%). The subjects were 24 men and women aged 40 to 50 years, considering the dropout. The test period was 4 weeks and skin moisture content was measured by Corneometer®. The results are shown in FIG. 2 as skin moisture increase rates at 1 week, 2 weeks, 3 weeks, and 4 weeks as a percentage of measured values before application.
도 2를 참조하여 보면, CK와 유근피 추출물이 모두 함유된 시료를 사용한 실험군이 가장 높은 피부 수분 증가율을 보였으며, 4주차에 48.34%를 나타내었다. 4주차에 CK만이 함유된 시료를 사용한 대조군 1은 39.02%의 피부 수분 증가율을 보였고, 유근피 추출물만이 함유된 대조군 2는 43.4%의 피부 수분 증가율을 보였다. CK와 유근피 추출물이 모두 함유되지 아니한 대조군 3은 4주차 35.07의 피부 수분 증가율을 보였다. Referring to FIG. 2, the experimental group using the sample containing both CK and the root extract showed the highest skin moisture increase rate, which was 48.34% at 4 weeks. At week 4, the control group 1 using the sample containing only CK showed a skin moisture increase rate of 39.02%, and the control group 2 containing only the myofibril extract showed a skin moisture increase rate of 43.4%. Control 3, which did not contain both CK and dermis extract, showed a skin moisture increase rate of 35.07 at 4 weeks.
Claims (8)
상기 혼합물은 진세노사이드 화합물 K 및 유근피 추출물이 6:4 내지 5:5 중량비의 혼합물인 피부 주름 개선용 조성물.
It contains a mixture of ginsenoside compound K and root extracts as an active ingredient,
The mixture is a ginsenoside compound K and the extract of dermis root skin is a mixture for improving skin wrinkles of 6: 4 to 5: 5 weight ratio.
상기 추출물은 물, 에탄올 또는 이들의 혼합용매 추출물인 피부 주름 개선용 조성물.
The method of claim 1,
The extract is water, ethanol or a mixed solvent extract of these compositions for improving skin wrinkles.
상기 조성물은 화장품 조성물인 것을 특징으로 하는 피부 주름 개선용 조성물.
The method according to claim 1 or 2,
The composition is a composition for improving skin wrinkles, characterized in that the cosmetic composition.
상기 조성물은 식품 조성물인 것을 특징으로 하는 피부 주름 개선용 조성물.
The method according to claim 1 or 2,
The composition is a composition for improving skin wrinkles, characterized in that the food composition.
상기 혼합물은 진세노사이드 화합물 K 및 유근피 추출물이 5:5 중량비의 혼합물인 피부 보습용 조성물.
It contains a mixture of ginsenoside compound K and root extracts as an active ingredient,
The mixture is a ginsenoside compound K and the extract of the roots of the root skin moisturizing composition is a mixture of 5: 5 weight ratio.
상기 추출물은 물, 에탄올 또는 이들의 혼합용매 추출물인 피부 보습용 조성물.
The method of claim 5,
The extract is water, ethanol or a mixed solvent extract of the skin moisturizing composition.
상기 조성물은 화장품 조성물인 것을 특징으로 하는 피부 보습용 조성물.
The method according to claim 5 or 6,
The composition is a skin moisturizing composition, characterized in that the cosmetic composition.
상기 조성물은 식품 조성물인 것을 특징으로 하는 피부 보습용 조성물.
The method according to claim 5 or 6,
The composition is a skin moisturizing composition, characterized in that the food composition.
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KR102548612B1 (en) * | 2022-12-21 | 2023-06-29 | 주식회사 프롬바이오 | Compositions for Improving Skin Wrinkles and for Skin Moisturizing Using an Extract of Parsnip |
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KR20020004896A (en) * | 2001-10-04 | 2002-01-16 | 이동건 | ANTIAGING COSMETIC COMPOSITIONS CONTAINING elm's root skin, ULMUS DAVIDIANA |
KR20050076911A (en) * | 2004-01-26 | 2005-07-29 | 주식회사 태평양 | A composition that contains ginsenoside f1 and/or compound k for skin external application |
KR20160081161A (en) * | 2014-12-31 | 2016-07-08 | (주)아모레퍼시픽 | Skin external composition for moisturizing or whitening the skin comprising compound K and acetic acid 16-hydroxy-octadeca-9,17-diene-12,14-diynyl ester |
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KR20020004896A (en) * | 2001-10-04 | 2002-01-16 | 이동건 | ANTIAGING COSMETIC COMPOSITIONS CONTAINING elm's root skin, ULMUS DAVIDIANA |
KR20050076911A (en) * | 2004-01-26 | 2005-07-29 | 주식회사 태평양 | A composition that contains ginsenoside f1 and/or compound k for skin external application |
KR20160081161A (en) * | 2014-12-31 | 2016-07-08 | (주)아모레퍼시픽 | Skin external composition for moisturizing or whitening the skin comprising compound K and acetic acid 16-hydroxy-octadeca-9,17-diene-12,14-diynyl ester |
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KR102548612B1 (en) * | 2022-12-21 | 2023-06-29 | 주식회사 프롬바이오 | Compositions for Improving Skin Wrinkles and for Skin Moisturizing Using an Extract of Parsnip |
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