KR101977381B1 - Control device and method for radiotherapy device - Google Patents

Abstract

The present invention relates to a control device and method for controlling a radiotherapy device. The device generates a reconstructed radiograph for each respiratory phase assuming organs, included in 3D cone beam CT images of the organs for each respiration phase, as subjects, and assuming a current position of a photographing unit for photographing a projection image to be the position of the photographing unit. Then, the device compares the reconstructed radiograph with the projection image to determine the respiratory phase of the projection image.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a radiotherapy apparatus,

The present invention relates to a control apparatus and method for controlling a radiation therapy apparatus, and more particularly, to a radiation therapy apparatus control apparatus for accurately calculating a respiration phase of a projection image.

During radiation therapy, the tumor may move by respiration, which may result in a deflection of the treatment beam around the tumor. To cope with this case, it is common to broaden the therapeutic beam irradiation range in consideration of the movement of the tumor, but there is a side effect in which normal tissue around the tumor is damaged.

Gating therapy techniques are currently in use to monitor the respiration to reduce damage to the surrounding normal tissue and to irradiate the treatment beam when breathing is within a certain range. In order to treat gating, the respiratory state needs to be identified. There are two methods, one is to use breathing sensor and the other is to grasp breathing state in real-time projection image. The method of using the breathing sensor is a method of measuring the breathing by using the breathing belt or the movement of the attached marker by using the optical camera.

The use of a respiratory belt or an optical camera allows for easy identification of the respiratory condition, but the belt or optical camera-related parts must be attached to the body, which may interfere with treatment because the patient is uncomfortable or obstructed. For this reason, there is a need for a technique to grasp the direct breathing state in a projection image obtained in real time by an X-ray imaging apparatus attached to a therapeutic apparatus. For example, the diaphragm can be detected in the projection image, and the breathing state (phase) can be grasped using the change in position. However, when the diaphragm is detected in the image, errors may often occur, and the accuracy of the breathing status is not high.

Patent Registration No. 10-1590153

The problem to be solved by the present invention is to reduce the error due to the respiratory phase determination by calculating the degree of similarity with respect to the region of interest of the projection image and the reconstructed image, and to reduce mutual information and structural similarity The present invention also provides an apparatus and method for controlling a radiation therapy apparatus, which can significantly reduce an error due to a respiratory phase determination by calculating the similarity between a projection image and a reconstruction image.

The problems to be solved by the present invention are not limited to the above-mentioned problems, and various problems can be further included within the scope of what is well known to those skilled in the art from the following description.

A controller for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographing section for capturing a projection image, and a radiation source for irradiating a radiation therapy beam according to an embodiment of the present invention, A 4D cone beam CT image collecting unit for collecting a 4D cone beam CT image as an image set, a cowl moving unit for moving the couch to include the organs of the patient in the photographing range of the photographing unit, A reconstructed image for each respiratory phase is generated based on the assumption that the position of the radiographic image is the position of the photographing unit and the organs included in the 3D cone beam CT images of the organ per respiration phase are assumed to be the subject, And a respiration phase determination unit for determining a respiration phase of the projection image.

The couch moving unit may move the couch so that the coordinates of the projection image of the couch and the coordinates of the 3D cone beam CT image of the organ by the respiration phase are matched.

Wherein the respiration phase determination unit determines the respiratory phase of the reconstructed image of the respiratory phase having the highest degree of similarity to the projected image as the respiratory phase of the projected image by calculating the similarity between the reconstructed image and the projection image by the respiratory phase, Can be calculated using mutual information and / or structural similarity.

Wherein the respiration phase determination unit determines a respiration phase of the projection image by calculating a degree of similarity between a region of interest of the reconstructed image and a region of interest of the projection image according to the respiration phase, Lt; / RTI >

And a radiation source control unit for controlling the radiation source to irradiate the radiation treatment beam when the respiration phase of the projection image is within a predetermined range.

Wherein the respiratory phase determining unit determines a current position of the photographing unit for photographing the projection image as a position of the photographing unit when the position of the photographing unit changes based on a treatment plan, And the respiration phase of the projection image can be determined again by comparing the reconstructed image by the respiration phase generated again with the projection image.

According to another embodiment of the present invention, there is provided a control method for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic section for capturing a projection image, and a radiation source for irradiating a radiation therapy beam, A step of acquiring a 4D cone beam CT image as a cone-beam CT image set, a step of moving the couch to include an organ of the patient in a photographing range of the photographing unit, and a step of acquiring a current position of the photographing unit, Position of the 3D cone-beam CT image by the respiration phase and generates a reconstructed image for each respiratory phase assuming the organs included in the 3D cone-beam CT image for each respiration phase as a subject, compares the reconstructed image for each respiration phase with the projected image, And determining a phase.

The moving step may include moving the couch so that the coordinates of the projection image of the couch and the coordinates of the 3D cone beam CT image of the organ by the respiration phase are matched.

Determining the respiratory phase of the reconstructed image of the respiratory phase having the highest degree of similarity to the projection image as the respiratory phase of the projected image by calculating the degree of similarity between the reconstructed image and the projection image by the respiratory phase, And the similarity may be calculated using mutual information and / or structural similarity.

Determining a respiratory phase of the projection image by calculating a degree of similarity between a region of interest of the reconstructed image and a region of interest of the projection image according to the respiratory phase, It may be an area whose brightness change is equal to or greater than a reference value.

And a radiation source control step of controlling the radiation source to irradiate the radiation treatment beam when the respiratory phase of the projection image is within a predetermined range.

Wherein the respiratory phase determining step determines a current position of the photographing unit for photographing the projection image as a position of the photographing unit when a position of the photographing unit changes based on a treatment plan, And reconstructing the respiration phase of the projection image by comparing the reconstructed image with the respiration phase generated again and the projection image, have.

In calculating the similarity between the projection image and the reconstructed image, the error according to the respiratory phase can be greatly reduced by calculating the similarity to the region of interest of the projection image and the reconstructed image, and further, by using the mutual information amount and the structural similarity method By calculating the similarity between the projected image and the reconstructed image, the error due to the determination of the respiratory phase can be greatly reduced.

The effects of the proposed invention are not limited to the effects mentioned above, and various effects can be further included within the scope of what is well known to those skilled in the art from the following description.

1 is a view showing a control apparatus for controlling a radiation treatment apparatus and a radiation treatment apparatus according to an embodiment of the present invention.
2 is a block diagram showing a detailed configuration of the control device.
3 is a diagram illustrating a process of generating a reconstructed image.
4 is a diagram illustrating a process of calculating a degree of similarity between a projection image and a reconstructed image.
FIG. 5 is a graph showing the similarity between the reconstructed image and the projected image according to the respiration phase according to the respiration phase.
6 is a flow chart illustrating a method of radiation therapy according to one embodiment.

The foregoing and further aspects are embodied through the embodiments described with reference to the accompanying drawings. It is to be understood that the components of each embodiment are capable of various combinations within an embodiment as long as no other mention or mutual contradiction exists. Furthermore, the proposed invention may be embodied in many different forms and is not limited to the embodiments described herein.

In order to clearly illustrate the claimed invention, parts not related to the description are omitted, and like reference numerals are used for like parts throughout the specification. And, when a section is referred to as " including " an element, it does not exclude other elements unless specifically stated to the contrary.

In addition, throughout the specification, when a part is referred to as being "connected" to another part, it is not limited to a case where it is "directly connected", but also an "electrically connected" . Further, in the specification, a signal means a quantity of electricity such as a voltage or a current.

As used herein, the term " block " refers to a block of hardware or software configured to be changed or pluggable, i.e., a unit or block that performs a specific function in hardware or software.

Hereinafter, a control apparatus for a radiation therapy apparatus according to an embodiment of the present invention will be described in detail with reference to the drawings.

1 is a view showing a control apparatus 100 for controlling a radiation treatment apparatus 3 and a radiation treatment apparatus 3 according to an embodiment, and Fig. 2 is a block diagram showing a detailed configuration of a control apparatus . FIG. 3 illustrates a process of generating a reconstructed image, FIG. 4 illustrates a process of calculating a similarity between a projected image and a reconstructed image, and FIG. 5 illustrates a process of calculating similarity between a reconstructed image and a projected image, Fig.

The radiotherapy apparatus and the control apparatus 100 may be implemented as separate apparatuses, but physically as a single apparatus.

The radiotherapy apparatus includes a couch in which a patient 19 is placed, a radiographic section 24, 30 for irradiating and receiving X-rays for a projection image, a radiation source 16 for irradiating a radiotherapy beam, and a circular gantry.

The couch can be freely moved up, down, left, and right with the bed on which the patient 19 is placed. As the couch moves, the patient 19 placed on the couch can also move together. As the patient 19 moves, the radiotherapy beam can be accurately irradiated to the affected part of the patient 19, and the projection image can be irradiated so that the projected image includes the affected part.

The photographing units 24 and 30 include an image source 24 for irradiating X-rays for a projection image and a detector 30 for receiving a projection image. The detector 30 receives X-rays passing through the patient 19 among the irradiated X-rays. The image source 24 and detector 30 may be Cone Beam Computed Tomography, which is a single set. Cone beam CT radiates cone-shaped X-ray beam. The image source 24 and the detector 30 face each other and irradiate and receive X-rays while rotating the patient around 360 degrees.

The radiation source 16 irradiates the radiation beam for radiation therapy. Depending on the treatment plan, the radiation beam can be irradiated to the affected part 19 of the patient.

The radiation source 16 irradiates a radiation treatment beam for radiation therapy, and the radiation treatment beam can be irradiated to the lesion according to a treatment plan. The radiation source 16 may include a linear accelerator (not shown) and a multi-leaf collimator (MLC) 20.

Linear accelerators accelerate electrons to emit high-energy radiation and are capable of irradiating radiation according to the shape of malignant or benign tumors located within the human body, enabling various energies and high dose rates.

The linear accelerator may be mounted on one side of the circular gantry and the linear accelerator may also rotate together as the circular gantry rotates.

At the end of the linear accelerator, a multi-collimator 20 can be mounted. One end of the multi-collimator 20 may be mounted on the linear accelerator and the other end may be fixed on the circular gantry to irradiate the beam of radiation towards the patient 19. [

The multileaf collimator 20 can adjust the intensity of the beam of radiation when more or less amount of the beam of radiation is required to treat the tissue of the patient 19, If displaced, the pattern of the radiation beam can be adjusted to irradiate the subject's tissue of the patient 19 with a radiation beam. The internal organs can be displaced by the respiration of the patient 19, and the multi-lobe collimator 20 can be controlled based on this displacement.

The circular gantry has a cylindrical structure with a hollow, the couch in which the patient 19 is disposed can be inserted into the hollow, and the circular gantry can rotate about the patient 19. Here, the cylindrical structure is not limited to a cylindrical shape over the entire hollow of the circular gantry, but may also be inclusive of a partially cylindrical shape.

The patient 19 can be guided in the hollow from one side of the circular gantry toward the other side of the circular gantry along a direction parallel to the rotation axis of the circular gantry. The couch can be automatically moved into the cavity of the circular gantry in the lying state of the patient 19 or moved by the manual button. Although not shown in detail, a rotary mechanism capable of rotating the circular gantry itself may be provided inside the circular gantry.

The radiation source 16, the image source 24 and the detector 30 may be mounted in a circular gantry. As the circular gantry rotates, the radiation source 16, the image source 24 and the detector 30 can rotate together. According to the treatment plan, the circular gantry rotates by a certain angle and then stops. 1, the radiation source 16 and the image source 24 may be mounted in a circular gantry at an angle of 90 degrees and the radiation source 16 and the detector 30 may be mounted in a circular It can be mounted on a gantry.

2, the control apparatus 100 for controlling the radiotherapy apparatus includes a 4D cone beam CT image acquisition unit 110, a couch movement unit 120, a respiration phase determination unit 130, and a linear accelerator module control unit 140 ). The control device 100 may include a control unit and a storage unit for controlling the control device 100 as a whole. The control unit may be implemented as a microcontroller or a microprocessor, and may execute a program stored in the storage unit. Each block according to FIG. 2 may refer to a functional block of program code.

The controller 100 may include a communication unit for transmitting and receiving data to / from external equipment through wired / wireless communication.

The 4D cone beam CT image collection unit 110 acquires a 4D cone beam CT image, which is a set of 3D cone beam CT images for each respiration phase. Before the treatment, the affected part of the patient 19 is photographed 4D by the general CT apparatus different from the photographing units 24 and 30 according to the embodiment of the present invention. The CT image is captured and the respiration monitoring signal is stored, and the CT image is matched with the imaging time and the respiration signal. This allows the CT data set per breathing phase to be reconstructed. The 4D cone beam CT image collection unit 110 receives the 4D cone beam CT image, which is a set of 3D cone beam CT images for each respiration phase generated by the external equipment, according to this process. At this time, the external equipment includes separate general CT equipment.

The couch moving unit 120 moves the couch so that the organs of the patient 19 are included in the photographing range of the photographing units 24 and 30. [ The couch moving unit 120 receives the image coordinates from the external equipment that has captured the 3D cone-beam CT image of the organ per respiration phase. The couch moving unit 120 moves the couch so that the photographing units 24 and 30 coincide with the coordinates of the image currently photographed and the received image coordinates. The coincidence is that the object corresponding to the specific coordinate of the image coordinate coincides with the object corresponding to the specific coordinate of the image photographed by the current photographing unit 24 or 30.

The respiratory phase determination unit 130 determines the current position of the photographing units 24 and 30 that irradiate the X-ray for the projection image as the positions of the photographing units 24 and 30 and includes the 3D cone-beam CT image of the long- And the respiration phase of the projected image is determined by comparing the reconstructed image with the respiration phase and the projected image.

Referring to FIG. 3, a reconstructed image (DRR) is a 2D image generated by accumulating 3D images (graylevels) existing on a straight line from the image source 24 to each pixel of the detector 30. Reconstructed images are generated from previously collected 4D cone beam CT images and are generated by respiration phase. The 4D cone beam CT directory is a database in which 4D cone beam CT images are collected.

Referring to FIG. 4, the respiration phase determination unit 130 compares the reconstructed image for each respiration phase with the projected image captured by the photographing units 24 and 30. That is, the respiratory phase determination unit 130 calculates the similarity between the reconstructed image according to the respiration phase and the projection image captured by the photographing units 24 and 30, and determines the respiration phase of the projected image based on the calculated similarity.

The patient 19 can not easily determine the respiratory phase contained in the projection image currently photographed by the photographing units 24 and 30 because the patient 19 continues breathing. In order to calculate the respiration phase of the currently projected image, the respiratory phase determination unit 130 calculates the similarity between the reconstructed image and the projection image according to the respiratory phase, and determines a specific respiration phase of the reconstructed image having the highest similarity to the projection image, Determine the respiratory phase. Similarity is calculated using mutual information and / or structural similarity (SSIM). By using two methods of calculating similarity, more similarity can be calculated. Accordingly, the respiration phase of the currently projected image can be accurately calculated.

The breathing phase determination unit 130 calculates the similarity between the ROI 300 of the reconstructed image and the ROI 200 of the projection image. In FIG. 4, the regions of interest 200 and 300 are displayed in a white solid line box on a projection image and a reconstruction image DRR. The region of interest (ROI) is an area for comparing the degree of similarity of the image, and is preferably set as an area periodically changed by respiration. In order to set the region of interest, the region of interest may be set to include a region with a large brightness change, and a region having a brightness change of more than a preset value may be set as a region of interest according to the respiration phase. When comparing the respiration phases, it is necessary to compare the region where the diaphragm is located as the region of interest and to understand the respiratory phase well.

The linear accelerator control unit 140 controls the linear accelerator to irradiate the radiation treatment beam when the respiratory phase of the projected image is within a predetermined range. The linear accelerator control unit 140 may be included in the radiation therapy apparatus as described above.

The treatment plan determines the conditions under which the beam of radiation will be irradiated. For example, a radiation treatment beam can be planned to be irradiated in a range of EX40% to IN40%. If the phase of the projection image is within the above condition, the linear accelerator control unit 140 controls the linear accelerator to irradiate the radiation treatment beam. The treatment plan includes not only the range of the respiratory phase but also the irradiation type, dose, and irradiation time of the linear accelerator.

The respiratory phase determination unit 130 determines the current position of the imaging units 24 and 30 that irradiate the projection image to the imaging units 24 and 30 when the positions of the imaging units 24 and 30 change based on the treatment plan The reconstructed images of the respiratory phases are reconstructed assuming the organs included in the 3D cone beam CT images of the organs according to the respiration phase as hypothetical positions, and the reconstructed images of the respiration phases are compared with the projected images. Phase. Depending on the treatment plan, the angles of the imaging units 24 and 30, the angle of the linear accelerator, or the dose of the linear accelerator may be changed. When these factors are changed, the respiration phase determination unit 130 determines again the respiration phase of the projected image.

In radiation therapy, the respiratory phase is expressed as IN0%, IN20%, IN100%, EX100%, EX50%, EX10%, etc. IN / EX means inspiration / evacuation and the figure means the amount of respiration in the chest .

Referring to FIG. 5, the respiratory phase is ten. The abscissa is the number of respiratory phases, and the ordinate is the SSIM value calculated through structural similarity (SSIM). The intake air or exhaust information is displayed on a line graph according to FIG. 5, and the line graph shows the degree of intake or exhaust as a percentage.

A control method of the radiation therapy apparatus according to another embodiment of the present invention will now be described in detail with reference to FIG. 6 is a flow chart illustrating a method of radiation therapy according to one embodiment.

The control method of the radiation therapy apparatus according to the embodiment of the present invention includes a 4D cone beam CT image acquisition step S610, a couch movement step S620, a breathing phase determination step S630, and a linear accelerator control step S640.

The 4D cone beam CT image acquisition step (S610) is a step of collecting a 4D cone beam CT image, which is a set of 3D cone beam CT images for each respiration phase. Before the treatment, the CT of the patient 19 is photographed 4D with a separate general CT distinguished from the imaging module 24 according to the present invention, and a breathing monitoring signal is stored at the same time as the CT imaging, Post-process the image. This allows the CT data set per breathing phase to be reconstructed. In the 4D cone beam CT image collection step S610, the 4D cone beam CT image collection unit 110 receives the 4D cone beam CT image, which is a set of 3-D cone beam CT images for each respiration phase generated by the external equipment according to the above-described procedure.

The couch moving step S620 is a step of moving the couch to include the organ of the patient 19 in the photographing range of the photographing module. In the couch moving step S620, the covariance moving unit 120 receives the image coordinates from the external equipment that has taken the 3D cone beam CT image of the long-term respiration phase, and the coordinates of the image photographed by the photographing module 24, So that the coordinates of the image coincide with each other. The coincidence is that the object corresponding to the specific coordinates of the image coordinates and the objects corresponding to the specific coordinates of the image currently photographed by the photographing units 24 and 30 coincide with each other.

In the respiratory phase determination step S630, assuming that the current positions of the photographing units 24 and 30 for photographing the projection image are the positions of the photographing units 24 and 30, the organs included in the 3D cone- The reconstructed image is reconstructed according to the respiratory phase assumed as the subject, and the respiration phase of the projected image is determined by comparing the reconstructed image with the respiration phase and the projected image.

In the respiratory phase determination step S630, the respiratory phase determination unit 130 compares the respiration-phase reconstructed image with the projection image captured by the photographing units 24 and 30. That is, in the respiratory phase determination step S630, the respiratory phase determination unit 130 calculates the similarity between the reconstructed image for each respiratory phase and the projection image captured by the imaging module, and determines the respiratory phase of the projected image based on the calculated similarity do.

The patient 19 can not easily determine the respiratory phase contained in the projection image currently photographed by the photographing units 24 and 30 because the patient 19 continues breathing. In order to calculate the respiration phase of the currently projected image, the respiratory phase determination unit 130 calculates the similarity between the reconstructed image and the projection image according to the respiratory phase, and determines a specific respiration phase of the reconstructed image having the highest similarity to the projection image, Determine the respiratory phase. Similarity is calculated using mutual information and / or structural similarity (SSIM). By using two methods of calculating similarity, more similarity can be calculated. Accordingly, the respiration phase of the currently projected image can be accurately calculated.

In the respiratory phase determination step S630, the respiration phase determination unit 130 calculates the similarity between the ROI 300 of the reconstructed image and the ROI 200 of the projection image. The region of interest (ROI) is an area for comparing the similarity of images, and is set as an area in which the shape changes periodically by respiration. In order to set the region of interest, the region of interest may be set to include a region with a large brightness change, and a region having a brightness change of more than a preset value may be set as a region of interest according to the respiration phase. When comparing the respiration phases, it is necessary to compare the region where the diaphragm is located as the region of interest and to understand the respiratory phase well.

In the linear accelerator control step S640, the linear accelerator controller 140 controls the linear accelerator to irradiate the radiation therapy beam if the respiratory phase of the projected image is within a predetermined range.

The treatment plan determines the conditions under which the beam of radiation will be irradiated. For example, a radiation treatment beam can be planned to be irradiated in a range of EX40% to IN40%. If the phase of the projection image is within the above condition, the linear accelerator control unit 140 controls the linear accelerator to irradiate the radiation treatment beam in the linear accelerator control step S640. The treatment plan includes the type of irradiation of the linear accelerator module 16, the dose, and the irradiation time as well as the range of the respiratory phase.

In the respiratory phase determination step S630, the respiratory phase determination unit 130 determines the current position of the photographing units 24 and 30 that irradiate the projection image when the positions of the photographing units 24 and 30 change based on the treatment plan Assuming that the position of the radiographing part (24, 30) is the same, the reconstructed image of the respiratory phase is reconstructed assuming the organs included in the 3D cone beam CT image of the organs according to the respiration phase as the subject, The images are compared to determine the respiration phase of the projected image. Depending on the treatment plan, the angles of the photographing portions 24 and 30, the angle of the linear accelerator, or the dose of the linear acceleration may be changed. When these factors are changed, the respiration phase determination unit 130 determines again the respiration phase of the projected image.

As described above, those skilled in the art will recognize that the present invention can be embodied in other specific embodiments without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative only and not restrictive of the scope of the invention. It should also be understood that the flow charts shown in the figures are merely sequential steps which are illustratively shown in order to achieve the most preferred results in practicing the proposed invention and that other additional steps may be provided or some steps may be deleted to be.

The technical features and implementations described herein may be implemented in digital electronic circuitry, or may be implemented in computer software, firmware, or hardware, including the structures described herein, and structural equivalents thereof, . Also, implementations that implement the technical features described herein may be implemented as computer program products, that is, modules relating to computer program instructions encoded on a program storage medium of the type for execution by, or for controlling, the operation of the processing system .

The computer-readable medium can be a machine-readable storage device, a machine-readable storage substrate, a memory device, a composition of matter that affects the machine readable propagation type signal, or a combination of one or more of the foregoing.

In the present specification, the term " apparatus " or " system " includes all apparatuses, apparatuses and machines for processing information, including, for example, a processor, a computer or a multiprocessor or a computer. The processing system may include, in addition to the hardware, all of the code that forms an execution environment for the computer program upon request, such as code comprising the processor firmware, a protocol stack, an information base management system, an operating system, .

A computer program, known as a program, software, software application, script or code, may be written in any form of programming language, including compiled or interpreted language or a priori, procedural language, Routines, or other units suitable for use in a computer environment.

On the other hand, a computer program does not necessarily correspond to a file in the file system, but may be stored in a single file provided to the requested program or in a plurality of interactive files (for example, one or more modules, File), or a portion of a file holding another program or information (e.g., one or more scripts stored in a markup language document).

A computer program may be embodied to run on multiple computers or on one or more computers located at one site or distributed across a plurality of sites and interconnected by a wired / wireless communication network.

On the other hand, computer readable media suitable for storing computer program instructions and information include, for example, semiconductor memory devices such as EPROM, EEPROM and flash memory devices, for example magnetic disks such as internal hard disks or external disks, And any type of non-volatile memory, media and memory devices, including CD and DVD discs. The processor and memory may be supplemented by, or incorporated in, special purpose logic circuits.

Implementations that implement the technical features described herein may include, for example, a back-end component such as an information server, or may include a middleware component, such as, for example, an application server, Or a client computer having a graphical user interface, or any combination of one or more of such backend, middleware or front end components. The components of the system may be interconnected by any form or medium of digital information communication, for example, a communication network.

Hereinafter, more specific embodiments capable of implementing the configurations including the systems and methods described herein will be described in detail.

The methods herein may be used, in part or in whole, through means for executing computer software, program code or instructions on one or more processors included in a server or server associated with a client device or a web-based storage system. The processor may be part of a computing platform, such as a server, a client, a network infrastructure, a mobile computing platform, a fixed computing platform, and the like, and may specifically be a type of computer or processing device capable of executing program instructions, code, The processor may further include a memory for storing a method, an instruction, a code and a program. If the memory does not include a memory, a method, an instruction, a code, and a CD- , A DVD, a memory, a hard disk, a flash drive, a RAM, a ROM, a cache, and the like.

Further, the systems and methods described herein may be used, in part or in whole, through a server, a client, a gateway, a hub, a router, or an apparatus executing computer software on network hardware. The software may be executed in various types of servers such as a file server, a print server, a domain server, an Internet server, an intranet server, a host server, a distributed server, A storage medium, a communication device, a port, a client, and other servers via a wired / wireless network.

In addition, the methods, commands, codes, etc. according to the proposed invention can also be executed by the server, and other devices needed to implement the method can be implemented as part of the hierarchical structure associated with the server.

In addition, the server can provide an interface to other devices including, without limitation, clients, other servers, printers, information base servers, print servers, file servers, communication servers, distributed servers, It is possible to facilitate remote execution of the program via the network.

Also, the central processor of the server may include instructions, code, etc., to be executed on different devices, and may further include at least one storage device capable of storing a method, an instruction, To be stored in the storage device.

On the other hand, the method herein may be used partly or entirely through a network infrastructure. The network infrastructure may include both a device such as a computing device, a server, a router, a hub, a firewall, a client, a personal computer, a communication device, a routing device, etc. and a separate module capable of performing each function, In addition to one device and module, it may further include storage media such as a story flash memory, buffer, stack, RAM, ROM, and the like. Also, methods, commands, code, etc. may be executed and stored by any of the devices, modules, and storage media included in the network infrastructure, and other devices required to implement the method may also be implemented as part of the network infrastructure .

In addition, the systems and methods described herein may be implemented in hardware or a combination of hardware and software suitable for a particular application. Herein, the hardware includes both general-purpose computer devices such as personal computers, mobile communication terminals, and enterprise-specific computer devices, and the computer devices may include memory, a microprocessor, a microcontroller, a digital signal processor, an application integrated circuit, a programmable gate array, Or the like, or a combination thereof.

Computer software, instructions, code, etc., as described above, may be stored or accessed by a readable device, such as a computer component having digital information used to compute for a period of time, such as RAM or ROM Permanent storage such as semiconductor storage, optical disc, large capacity storage such as hard disk, tape, drum, optical storage such as CD or DVD, flash memory, floppy disk, magnetic tape, paper tape, Memory such as storage and dynamic memory, static memory, variable storage, network-attached storage such as the cloud, and the like. Here, the commands and codes can be classified into information-oriented languages such as SQL and dBase, system languages such as C, Objective C, C ++, and assembly, architectural languages such as Java and NET and application languages such as PHP, Ruby, Perl and Python But are not limited thereto, and may include all languages well known to those of ordinary skill in the art to which the claimed invention belongs.

In addition, " computer readable media " as described herein includes all media that contribute to providing instructions to a processor for program execution. But are not limited to, non-volatile media such as information storage devices, optical disks, magnetic disks, and the like, transmission media such as coaxial cables, copper wires, optical fibers, etc. that transmit information to volatile media such as dynamic memory and the like.

On the other hand, configurations implementing the technical features of the proposed invention included in the block diagrams and flowcharts shown in the drawings attached hereto, mean the logical boundaries between the configurations.

However, according to an embodiment of the software or hardware, the depicted arrangements and their functions may be implemented in the form of a stand alone software module, a monolithic software structure, a code, a service and a combination thereof and may execute stored program code, All of these embodiments are also considered to be within the scope of the claimed invention since they can be stored in a medium executable on a computer with a processor and their functions can be implemented.

Accordingly, the accompanying drawings and the description of the invention are intended to be illustrative of the technical features of the proposed invention, but should not be construed as merely inferring unless a specific arrangement of software for implementing such technical features is explicitly mentioned. That is, it should be understood that various embodiments described above may exist, and that such embodiments may be partially modified while retaining the same technical features as the proposed invention, so that they also fall within the scope of the claimed invention.

It should also be understood that although the flowcharts depict the operations in the drawings in a particular order, they are shown for the sake of obtaining the most desirable results, and such operations must necessarily be performed in the specific order or sequential order shown, Should not be construed as being. In certain cases, multitasking and parallel processing may be advantageous. In addition, the separation of the various system components of the above-described embodiments should not be understood as requiring such separation in all embodiments, and the described program components and systems are generally integrated into a single software product, It can be packaged.

As such, the specification is not intended to limit the invention as suggested by the specific terminology presented. While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the scope of the invention as defined by the appended claims. , Changes and modifications can be made.

The scope of the present invention is defined by the appended claims rather than the foregoing description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents are included in the scope of the claimed invention .

16: radiation source
19: Patient
20: Multilayer collimator
24: Video source
30: Detector
100: Control device
110: 4D cone beam CT image collection unit
120: Couch moving part
130: Respiration phase determination unit
140: linear accelerator control unit
200: area of interest
300: Interest area
S610: 4D cone beam CT image acquisition step
S620: Couch moving step
S630: Respiration phase determination step
S640: Linear accelerator control step

Claims (12)

A control apparatus for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic section for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
A 4D cone beam CT image acquisition unit for collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
A cowl moving part for moving the cowl so that the organs of the patient are included in the photographing range of the photographing part, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, A respiratory phase determination unit for comparing a reconstructed image of the star with the projection image to determine a respiration phase of the projection image,
Lt; / RTI >
Wherein the respiratory phase determining unit comprises:
Wherein the respiration phase of the reconstructed image of the respiratory phase having the highest degree of similarity to the projection image is determined as the respiratory phase of the projected image by calculating the similarity between the reconstructed image and the projection image by the respiratory phase, ) Or structural similarity.
controller. The method of claim 1,
The cowl-
And moves the couch so that the coordinates of the projection image of the couch and the coordinates of the 3D cone-beam CT image of the organ by the respiration phase are matched. The method of claim 1,
And a radiation source control unit for controlling the radiation source to irradiate the radiation treatment beam when the respiratory phase of the projection image is within a predetermined range. A control apparatus for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic section for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
A 4D cone beam CT image acquisition unit for collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
A cowl moving part for moving the cowl so that the organs of the patient are included in the photographing range of the photographing part, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, A respiratory phase determination unit for comparing a reconstructed image of the star with the projection image to determine a respiration phase of the projection image,
Lt; / RTI >
Wherein the respiratory phase determining unit comprises:
Determining a respiratory phase of the projection image by calculating a degree of similarity between a region of interest of the reconstructed image and a region of interest of the projection image,
The region of interest is a region in which the change in brightness is above a reference value according to the respiration phase
controller. delete A control apparatus for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic section for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
A 4D cone beam CT image acquisition unit for collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
A cowl moving part for moving the cowl so that the organs of the patient are included in the photographing range of the photographing part, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, A respiratory phase determination unit for comparing a reconstructed image of the star with the projection image to determine a respiration phase of the projection image,
Lt; / RTI >
The breathing phase determination unit
If the position of the photographing unit changes based on the treatment plan, the current position of the photographing unit for photographing the projection image is assumed to be the position of the photographing unit, and the organs included in the 3D cone- Generating a reconstructed image for each respiration phase;
The respiration phase of the projection image is determined again by comparing the reconstructed image by the respiration phase generated again with the projection image
controller. A control method for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic part for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
Collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
Moving the couch so that the organs of the patient are included in the photographing range of the photographing unit, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, Determining a respiration phase of the projected image by comparing the star reconstructed image with the projected image
Lt; / RTI >
Wherein the breathing phase determination step comprises:
Calculating a similarity between the reconstructed image and the projection image by the respiratory phase to determine a respiratory phase of the reconstructed image of the respiratory phase having the highest degree of similarity to the projected image as a respiratory phase of the projected image,
The degree of similarity may be calculated using mutual information or structural similarity
Control method. 8. The method of claim 7,
Wherein,
And moving the couch so that the coordinates of the projection image of the couch and the coordinate of the 3D cone beam CT image of the organ by the respiration phase are matched. 8. The method of claim 7,
Further comprising a radiation source control step of controlling the radiation source to irradiate the radiation treatment beam when the respiratory phase of the projection image is within a predetermined range. A control method for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic part for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
Collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
Moving the couch so that the organs of the patient are included in the photographing range of the photographing unit, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, Determining a respiration phase of the projected image by comparing the star reconstructed image with the projected image
Lt; / RTI >
Wherein the breathing phase determination step comprises:
Determining a respiratory phase of the projection image by calculating a degree of similarity between a region of interest of the reconstructed image and a region of interest of the projection image by the respiratory phase,
The region of interest is a region in which the change in brightness is above a reference value according to the respiration phase
Control method. delete A control method for controlling a radiation therapy apparatus including a couch in which a patient is placed, a radiographic part for capturing a projection image, and a radiation source for irradiating a radiation treatment beam,
Collecting a 4D cone beam CT image, which is a 3D cone beam CT image set of an organ per respiration phase,
Moving the couch so that the organs of the patient are included in the photographing range of the photographing unit, and
A reconstructed image for each respiration phase is generated assuming that the current position of the photographing unit for photographing the projection image is the position of the photographing unit and that the organs included in the 3D cone beam CT images of the respiration phase organs are the subject, Determining a respiration phase of the projected image by comparing the star reconstructed image with the projected image
Lt; / RTI >
The breathing phase determination step
If the position of the photographing unit changes based on the treatment plan, the current position of the photographing unit for photographing the projection image is assumed to be the position of the photographing unit, and the organs included in the 3D cone- Reconstructing the respiration phase reconstructed image, and
And reconstructing the respiration phase of the projection image by comparing the reconstructed image of respiration phase and the projection image again,
Control method.

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