KR101967226B1 - Hemodynamics simulation method using partition of coronary artery volume - Google Patents
Hemodynamics simulation method using partition of coronary artery volume Download PDFInfo
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Abstract
The present invention relates to a method for modeling blood flow dynamics using a volume of a coronary branching tube, the method comprising: capturing an image of at least a portion of a coronary artery; A dividing step of dividing an image obtained through the photographing step into regions corresponding to respective coronary branch tubes; A volume calculating step of calculating a volume of the divided region through the dividing step; A blood flow calculation step of calculating a blood flow amount flowing into at least one of the coronary branch tubes by using the volume of the coronary branch tubes obtained through the volume calculating step; And a modeling step of performing blood flow modeling using blood flow in at least a portion of the coronary branching tube calculated in the blood flow calculation step.
Description
The present invention relates to a method for modeling blood flow dynamics using the volume of a coronary branch tube. More specifically, the blood flow modeling can be performed by estimating the blood flow volume in each coronary branch tube through the volume of each coronary branch tube. A blood flow dynamics modeling method using the volume of coronary branch tubes.
Coronary arteries are the main blood vessels that supply blood to the myocardial tissue of the heart, and blood supply is limited due to vascular stenosis produced by atherosclerosis and the like, and ultimately may cause serious symptoms such as myocardial infarction.
For more accurate diagnosis of the severity of stenosis lesions, information about hemodynamic functional diagnostic factors such as myocardial fraction reserve and wall shear stress plays an important role.
In order to secure such data, non-invasive tests such as electrocardiogram, biodiagnostic index test, exercise load electrocardiogram test, single positron emission computed tomography (SPECT), and positron emission tomography (PET) can be performed. However, these methods are difficult to provide a direct assessment of lesions, and furthermore, it is difficult to extract hemodynamic functional information.
Therefore, we deduce the resistance of the coronary arteries and derive a relationship with the blood flow splitting values to each coronary branch. Based on this, coronary hemodynamics computer simulation is performed to extract hemodynamic functional information. New ways to do this are needed.
Accordingly, an object of the present invention is to solve such a conventional problem, and by using the volume in each coronary branch tube, it is possible to calculate blood flow in each coronary branch tube and perform blood flow modeling. The present invention provides a method for modeling blood flow dynamics using the volume of an arterial branch tube.
According to one aspect of the invention, the imaging step of obtaining an image of at least a portion of the coronary artery; A dividing step of dividing the image acquired through the photographing step into a plurality of regions corresponding to each of the coronary branch tubes; A volume calculating step of calculating a volume of the divided region through the dividing step; A blood flow calculation step of calculating a blood flow amount flowing into at least one of the coronary branch tubes by using the volume of the coronary branch tubes obtained through the volume calculating step; It may provide a blood flow dynamics modeling method using the volume of the coronary branching tube, including; modeling step of performing blood flow modeling using the blood flow in at least a portion of the coronary branching pipe calculated in the blood flow calculation step.
The coronary branching tube may include a left anterior Descending Artery (LAD), a left circumplex artery (LCX), and a right coronary artery (RCA).
In addition, the imaging step is preferably performed using computed tomography (CT), selective computed tomography (CT) or magnetic resonance imaging (MRI).
In addition, the blood flow determination step is preferably in accordance with the following formula.
Where Q is the volume of blood in the coronary branch and V is the volume of the coronary branch.
In addition, after the modeling step, it is preferable to perform a blood flow dynamics simulation by using the image acquired through the photographing step and the blood flow modeling data obtained through the modeling data.
According to another aspect of the present invention, a computer-readable recording medium storing a program for executing the method of claim 5 on a computer may be provided.
According to the present invention, blood flow can be inferred in each of the coronary branch tubes without having to perform complicated calculations, and thus blood flow modeling can be performed more quickly.
1 is a flow chart schematically showing a blood flow dynamics modeling method using the volume of the coronary branching tube according to an embodiment of the present invention,
FIG. 2 is a view schematically showing an image captured by an imaging step of the hemodynamic modeling method using the volume of the coronary branching tube according to FIG. 1,
FIG. 3 is a diagram schematically illustrating a state in which an image is divided into different regions through the dividing step of the hemodynamic modeling method using the volume of the coronary branching tube according to FIG. 1.
Hereinafter, with reference to the accompanying drawings will be described in detail the blood flow dynamics modeling method using the volume of the coronary branching tube according to an embodiment of the present invention. Like reference numerals in the drawings denote like elements.
1 is a flow chart schematically showing a blood flow dynamics modeling method using the volume of the coronary branching tube according to an embodiment of the present invention.
Referring to FIG. 1, the blood flow dynamics modeling method using the volume of the coronary branching tube (S100) according to an embodiment of the present invention calculates the volume of the coronary branching tube, and infers the blood flow in the coronary branching tube. Finally, blood flow modeling and simulation in the coronary branch can be performed, and the imaging step (S110), the segmentation step (S120), the volume calculation step (S130), the blood flow calculation step (S140) and the modeling step (S150). ).
FIG. 2 is a view schematically illustrating an image photographed through a photographing step of the blood flow dynamics modeling method using the volume of the coronary branching tube according to FIG. 1.
Referring to FIG. 2, in the photographing step S110, at least a portion of the coronary artery is photographed to acquire an image of at least a portion of the coronary artery.
Here, the image of at least a portion of the coronary arteries is preferably a three-dimensional image so that the volume in the coronary branch canal can be calculated.
In addition, imaging may be performed on at least a portion of the heart as well as at least a portion of the coronary arteries.
Coronary artery can be divided into left coronary artery (LCA) and right coronary artery (RCA), and left coronary artery is left anterior Descending Artery (LAD) and left coronary artery. It may include a left circumplex artery (LCX).
That is, the coronary branch canal may include a left anterior Descending Artery (LAD), a left circumplex artery (LCX), and a right coronary artery (RCA).
Here, the coronary branch tubes may further comprise respective branches.
In more detail, for the right coronary artery (RCA), an acute marginal branch can be taken to include in the image, and for the left coronary artery (LCA), It includes a left main coronary artery, and the left anterior Descending Artery (LAD) may include branches such as a diagonal branch and a septal branch. The left circumplex artery (LCX) may include an obtuse marginal branch or the like.
Meanwhile, according to an embodiment of the present invention, the photographing step S110 is performed using computed tomography (CT), selective computed tomography (MRI) or magnetic resonance imaging (MRI). Can be performed.
Of course, the present invention is not limited thereto, and non-invasive imaging methods such as ultrasound (US) or invasive imaging methods such as digital subtraction angiography (DSA) may be used to acquire images in the coronary arteries.
On the other hand, since such an image acquisition method is a well-known technique, detailed description of each image acquisition method is omitted here.
FIG. 3 is a diagram schematically illustrating a state in which an image is divided into different regions through the dividing step of the hemodynamic modeling method using the volume of the coronary branching tube according to FIG. 1.
Referring to FIG. 3, the dividing step (S120) is a step of dividing the image into regions corresponding to respective coronary branch tubes.
For example, the area corresponding to the right coronary artery (RCA) is the first area, the area corresponding to the left anterior Descending Artery (LAD) is the second area, and the left circumplex artery. An area corresponding to: LCX may be divided into a third area.
On the other hand, in the above-described dividing step (S120), the method of dividing each of the coronary branch tubes does not have to be performed in a specific method.
On the other hand, it was described that each of the coronary branching tubes divided into three areas, but is not limited to this, divided into two areas for the left coronary artery and right coronary artery, and each region for the right coronary artery Naturally, it can be performed by dividing into regions for and finally obtaining three regions.
The volume calculation step (S130) is a step of calculating the volumes of the three myocardial regions obtained through the above-described division step (S120).
The region divided by the above-described dividing step S120 may be interpreted as a three-dimensional region, and the volume of the three-dimensional region may be easily calculated.
Here, the volume in each of the coronary branch tubes may be calculated directly, or the volume ratio in each of the coronary branch tubes may be calculated.
The blood flow calculation step (S140) is a step of estimating the blood flow volume to each of the coronary branch pipes using the volume in each of the coronary branch pipes calculated through the volume calculation step (S130) described above.
First, the blood flow to each of the coronary branch tubes is in accordance with the following formula.
Where Q is the volume of blood in the coronary branch and V is the volume in the coronary branch. The inventors obtained significant data that the volume of the coronary branching tube is proportionally proportional to the blood flow flowing to the coronary branching tube through a number of experiments, and the above-mentioned formula can be derived using this proportional relationship.
That is, the amount of blood flowing through each coronary branch is proportional to the volume in each coronary branch.
According to one embodiment of the invention, the blood flow calculation step (S140) can obtain the ratio of the blood flow flowing to each coronary artery branch. In other words, the volume ratio for each coronary branch tube can be obtained through the volume calculation step (S130) described above, and the blood flow ratio of each coronary branch tube can be inferred.
On the other hand, since the blood flow is proportional to the volume, the blood flow rate is also proportional to the volume ratio, and the volume ratio at each coronary branch can be seen as the ratio of the blood flow to each coronary branch.
The modeling step (S150) is a step of performing blood flow modeling using the blood flow in the coronary branching tube calculated in the blood flow calculation step (S140) described above.
In other words, blood flow modeling may be performed by performing numerical analysis based on the blood flow volume in the coronary branch.
On the other hand, blood flow modeling has been conventionally performed using the blood flow in the coronary branch, but since there is no way to estimate this, Murray's law, which is a well-known theory, was generally applied. Murray's law refers to the law that the blood flow (Q d ) is proportional to the power of the blood vessel diameter (d) can be expressed by the following formula.
Where d is the diameter of the vessel and a is a power constant that is usually defined as 1.5 to 3 and is not precisely defined.
However, the power constants are not accurately determined in the coronary region, and there is a difficulty in determining the representative vessel diameter because the vessel diameter continuously changes along the longitudinal direction.
In contrast, the blood flow calculation step (S140) according to an embodiment of the present invention can calculate the volume of each coronary branch tube, through which it is possible to estimate the flow of blood flow to each coronary branch tube, In a modeling step S150 according to an embodiment of the present invention, more accurate simulation may be performed.
On the other hand, according to an embodiment of the present invention, a simulation step of performing a blood flow dynamics computer simulation using the image obtained through the above-described imaging step (S110) and the blood flow modeling data obtained through the modeling step (S150) ( S160) may be further included.
By performing a computer simulation through the simulation step (S160), information on the coronary blood flow of the patient's body, for example, pressure, velocity, FFR, etc. may be obtained and output to the outside.
In other words, the simulation step S160 may analyze a three-dimensional equation of blood flow using a computer system, and may use a method such as a numerical solution. Through this simulation step (S170), the coronary artery, more specifically the left anterior Descending Artery (LAD), the left Circumplex Artery (LCX) and the Right Coronary Artery (RCA), respectively Various hemodynamic characteristics, parameters, etc., including blood flow and blood pressure in Esau can be calculated.
Furthermore, the calculated characteristic or parameter may be displayed externally on an angiography image or the like.
On the other hand, one embodiment of the present invention described above can be written in a program that can be executed in a computer, it can be implemented in a general-purpose digital computer to operate the program using a computer-readable recording medium.
Computer readable media can be any available media that can be accessed by a computer and includes both volatile and nonvolatile media, removable and non-removable media. In addition, computer readable media may include both computer storage media and communication media. Computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data. Communication media typically includes computer readable instructions, data structures, program modules, and may include any information delivery media.
The scope of the present invention is not limited to the above-described embodiments, and various modifications or variations can be made without departing from the spirit and scope of the present invention, and such modifications or variations are also within the scope of the present invention. Will see.
S100: Blood flow dynamics modeling method using volume of coronary branch
S110: shooting step S120: division step
S130: volume calculation step S140: blood flow calculation step
S150: Modeling Step S160: Simulation Step
Claims (6)
A photographing step of obtaining an image of at least a portion of the coronary artery;
A dividing step of dividing the image acquired through the photographing step into a plurality of regions corresponding to each of the coronary branch tubes;
A volume calculating step of calculating a volume of the divided region through the dividing step;
A blood flow calculation step of calculating a blood flow amount flowing into at least one of the coronary branch tubes by using the volume of the coronary branch tubes obtained through the volume calculating step;
A modeling step of performing blood flow modeling using blood flow in at least a portion of the coronary branching tube calculated in the blood flow calculation step,
The modeling step
A hemodynamic modeling method using the volume of the coronary artery branch, characterized in that the numerical analysis is performed using the calculated blood flow in the coronary artery branch as a boundary condition.
The coronary branch is a volume of a coronary branch that includes a left anterior Descending Artery (LAD), a left circumplex artery (LCX) and a right coronary artery (RCA). Blood flow dynamics modeling method.
The imaging step is a blood flow dynamics using the volume of the coronary branching tube, which is performed using computed tomography (CT), selective computed tomography (MRI) or magnetic resonance imaging (MRI). Modeling method.
The blood flow calculation step is blood flow dynamics modeling method using the volume of the coronary branching tube according to the following formula.
Where Q is the volume of blood in the coronary branch and V is the volume of the coronary branch.
After the modeling step, hemodynamic modeling method using the volume of the coronary branching tube to perform a blood flow dynamics simulation using the blood flow modeling data obtained through the image and the modeling data obtained through the imaging step.
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