KR101961438B1 - Data providing apparatus, and method - Google Patents

Abstract

According to the present invention, there is provided a data providing apparatus, method, and data providing method for studying a disease mechanism, and a computer readable recording medium on which a program for executing the data providing method is recorded. The computer readable recording medium can be permanently used from biomedical cells, Electronic data that is not damaged according to use can be acquired and electronic data of the obtained biomolecules can be traded at an appropriate price.

Description

[0002] Data providing apparatus, and method for providing biological data for disease mechanism research,

The present invention relates to a data providing apparatus and method for providing biological data for disease mechanism research.

Human tumor tissues have been studied using various research methods such as dielectrics, transcripts, protein bodies, metabolites, etc. to find the cause of cancer, to increase the accuracy of cancer diagnosis, and to improve the therapeutic effect of cancer . In particular, we are studying cancer through cancer tissue in cancer patients. For the study of tissue cells, we already have a tissue banking system in many hospitals and laboratories both domestically and externally, and manage patient organizations.

Because the tissue must be kept in liquid nitrogen or frozen, there was a problem that cost a lot each year.

In addition, researchers studying cancer must go through the process of purchasing the necessary tissues and extracting derivatives such as DNA / RNA / protein / metabolites in advance for their own research. In recent years, Analysis method (NGS) is widely used, and DNA / RNA base sequence analysis of cancer or normal tissue is performed.

However, because tissue cells must be kept in liquid nitrogen or frozen state, they require a lot of storage costs and the process of extracting derivatives such as DNA / RNA / protein / metabolites on one tissue cell is also time consuming and costly There is a problem that it is necessary.

Furthermore, in the case of errors in the extraction of various derivatives (DNA, RNA, Protein, etc.) from human tumor tissues, the information on the extracted derivatives is not reliable, and in the process in which the derivatives are erroneously extracted from the human tumor tissue There is a problem that the human tumor tissue having a limited quantity is wasted.

Because of the high cost of cancer research, in reality, only a limited number of researchers tend to be monopolized by tissue cells, and the tissue is wasted due to erroneous extraction processes.

Korea Patent Publication No. 2007-0081157

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and it is an object of the present invention to provide an apparatus and a method for converting data produced through a large capacity sequencing method (NGS) A data providing apparatus, a method, and a data providing apparatus capable of minimizing the unnecessary repetition of the same process at a great cost in order to obtain the same data as existing data by storing the data in a database and providing the data to a user at the request of a user And a computer-readable recording medium on which a program for executing the method is recorded.

According to an aspect of the present invention, there is provided a method of providing data, the method comprising: receiving a data request from a user terminal; Determining a property of data to be provided to a user terminal based on a condition included in the data request; A data retrieval step of retrieving data corresponding to the attribute of the data; A pricing step of determining the price of the data in consideration of information on a creator of the searched data, a time required for generation, and resources required for generation; And a data providing step of providing display information including the data and the price of the data to the user terminal.

In the method, the condition included in the data request includes at least one of a target substance of the data, a kind of the data, a kind of a processing method of the data, a processing state of the data, and a generation time of the data can do.

In the above method, the condition included in the data request includes at least one of a budget range and a total limit amount of the data, and the data providing step may include a minimum amount or a maximum amount included in the price range Extracting a part of the data and providing the extracted data to the user terminal or extracting one or more pieces of data from the data so that the total sum of prices of the extracted data does not exceed the total limit amount, And an optional providing step of providing to the terminal.

In the method, the display information may further include at least one of an effect obtainable through the data and a content included in the data.

Wherein the information about the creator includes at least one of a position at the time of creation of the constructor and a current position and the price of the data is at least one of the position at the time of creation of the constructor and the current position As shown in FIG.

In the method, the price of the data may be differentiated in consideration of at least one of whether the user requesting the data and the creator generating the data, and the relation between the user and the data.

In the above method, the information on the creator includes level information, and the level information includes a number of data generated by the creator, a cumulative sales amount of data generated by the creator, an import from the data generated by the creator, May be determined in consideration of at least one of.

According to another aspect of the present invention, there is provided a data providing apparatus including: a data request receiving unit receiving a data request from a user terminal; A data attribute determination unit for determining an attribute of data to be provided to a user terminal based on a condition included in the data request; A data retrieving unit for retrieving data corresponding to the attribute of the data; A pricing unit for determining a price of the data in consideration of information on a creator of the searched data, a time required for generation, and resources required for generation; And data providing means for providing the user terminal with display information including the data and the price of the data.

In the apparatus, the condition included in the data request includes at least one of a target substance of the data, a kind of the data, a kind of a processing method of the data, a processing state of the data, and a generation time of the data can do.

The apparatus of claim 1, wherein the condition included in the data request includes at least one of a budget range and a total limit amount of the data, and the data providing unit may include a minimum amount or a maximum amount included in the price range, Extracting one or more pieces of data from the data so that the total sum of the prices of the extracted data does not exceed the total limit amount, and extracting the extracted data from the user terminal And an optional providing unit for providing the information.

In the apparatus, the display information may further include at least one of an effect obtainable through the data and a content included in the data.

Wherein the information on the creator includes at least one of a position at the time of creation of the constructor and a current position, the price of the data is at least one of a position at the time of creation of the constructor, Can be determined differentially.

In the apparatus, the price of the data may be differentially determined in consideration of at least one of whether the user requesting the data and the creator generating the data, and the relation between the user and the data.

In the apparatus, the information on the creator includes level information, the level information includes a number of data generated by the creator, a cumulative sales amount of data generated by the creator, an import from the data generated by the creator, May be determined in consideration of at least one of.

In addition to this, another method for implementing the present invention, another system, and a computer-readable recording medium for recording a computer program for executing the method are further provided.

Other aspects, features, and advantages other than those described above will become apparent from the following drawings, claims, and the detailed description of the invention.

According to the apparatus and method for providing data according to the present invention, it is possible to obtain electronic data which can be permanently used from biological cells to be directly extracted from a target object and which is not damaged according to use, and more specifically, A, T, G, C, etc., the electronic data of the obtained living cells can be traded at an appropriate price. It is also possible to provide the user with information about the creator of the data, which is difficult to collect and whose quantity is limited, as meta data, which can help the user to purchase the data, It is possible to greatly reduce research cost and research time of researchers who use the data repeatedly by minimizing unnecessary repetition of the same process at a great cost. Here, the data may be biological data for cancer-causing mechanism studies.

Particularly, when a program for executing a data providing apparatus, method, and data providing method according to the present invention is used for providing data related to a human tumor tissue, it is possible that researchers can research without being limited by time and money Ultimately, it can be possible to treat patients with cancer and to treat them individually.

1 is a diagram illustrating a configuration of a data providing system according to an embodiment of the present invention.
2 is a block diagram illustrating a data providing apparatus according to an embodiment of the present invention.
3 is a diagram showing data stored in a database group when data of a data providing apparatus is limited to data on a human tumor tissue.
4 is a flowchart illustrating a data providing method according to another embodiment of the present invention.
5 is a flowchart illustrating a data providing method according to another embodiment of the present invention.
6 is a flowchart illustrating a data providing method based on a data providing apparatus according to another embodiment of the present invention.
7 is a diagram for explaining a process of generating data from a living cell.
8 and 9 are flowcharts of a data providing method for disease mechanism research according to embodiments of the present invention.
FIG. 10 is a block diagram illustrating a structure of a data generating unit that may be additionally included in a data providing apparatus for disease mechanism research according to embodiments of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the detailed description. The effects and features of the present invention and methods of achieving them will be apparent with reference to the embodiments described in detail below with reference to the drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings, wherein like reference numerals refer to like or corresponding components throughout the drawings, and a duplicate description thereof will be omitted .

In the following embodiments, the terms first, second, and the like are used for the purpose of distinguishing one element from another element, not the limitative meaning.

In the following examples, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

In the following embodiments, terms such as inclusive or possessed mean that a feature or element described in the specification is present, and does not exclude the possibility that one or more other features or components are added in advance.

If certain embodiments are otherwise feasible, the particular process sequence may be performed differently from the sequence described. For example, two processes that are described in succession may be performed substantially concurrently, and may be performed in the reverse order of the order described.

FIG. 1 is a block diagram illustrating a data providing system for disease mechanism research according to an embodiment of the present invention. Referring to FIG.

Referring to FIG. 1, a data providing system 1 according to an embodiment of the present invention includes a data providing apparatus 10, an operator terminal 30, a user terminal 50, and a creator terminal 51. It also includes a communication network 70 for interconnecting the operator terminal 30, the user terminal 50, the creator terminal 51, and the data providing apparatus 10.

1 includes one operator terminal 30, one user terminal 50, and one creator terminal 51, the data providing system 1 is provided with one And may include a plurality of operator terminals 30, a user terminal 50, and a creator terminal 51.

The data providing apparatus 10 provides a means for providing information on cancer-related tissues or cells to a person who intends to perform cancer-related research. The data providing apparatus 10 can provide data for diagnostic tests, predictive tests, donor tests, neonatal screening tests, prenatal diagnosis tests, and pre-implantation tests. The data providing apparatus 10 can process the mutation at the DNA level, the structural abnormality of the genome, the abnormality of the chromosome, the change of the metabolite, etc. from the living body cell obtained from the subject. At this time, it is possible to control the biological cells obtained from the target body to be processed in an appropriate manner. The data providing apparatus 10 can retrieve the data corresponding to the data request received from the user terminal 50 and determine the price for the data. The data providing apparatus 10 can provide the data for cancer-related research according to a request from a user, thereby reducing the labor required to generate the same data every research, and even if the cancer-related data is not directly obtained, And storage cost is significantly lower than that of storing tissues or cells.

The data providing apparatus 10 can receive data requests from the operator terminal 30, the user terminal 50, and the creator terminal 51 and provide data to each terminal. Although FIG. 1 shows one data providing apparatus, a plurality of data providing apparatuses may exist depending on the amount of connection or the amount of data. In this case, the data providing system 1 includes a layer 4 switch (not shown) that measures and compares the current load of each data providing apparatus and performs load balancing so that each data providing apparatus can efficiently process the job Not shown).

The data providing apparatus 10 may periodically receive specific data from the operator terminal 30 for maintenance and repair of the program for updating and operating the data stored therein.

The operator terminal 30 may be one of a personal computer (PC) or a workstation and may be connected to the data providing apparatus 10 to update and update the data stored in the data providing apparatus 10 And performs maintenance and repair of the program for the operation of the data providing apparatus 10. [

After the user accesses the data providing apparatus 10 via the wired / wireless network, the user terminal 50 can register the member for the data providing service. In addition, the user terminal 50 can be used to search for, select, and settle the type of data to be provided by the user.

The creator terminal 51 is a kind of user terminal used by an expert capable of generating data of the same kind as the data stored in the data providing device 10. [ That is, the creator terminal 51 essentially includes the function of the user terminal 50. [ The creator terminal 51 may include a function of allowing the operator to update the data stored in the data providing apparatus 10 through the operator terminal 30 by requesting the operator terminal 30 to upload data.

The operator terminal 30 can give an identification code for distinguishing the user terminal 50 and the creator terminal 51 to the user terminal 50 and the creator terminal 51, respectively. The operator terminal 30 can make a data upload request only to the creator terminal 51 having an identification code capable of making an upload request so as to secure the quality and reliability of data that can be stored in the data providing apparatus 10 .

1, the user terminal 50 and the creator terminal 51 are smart phones, but the user terminal 50 and the creator terminal 51 are not limited to specific devices, , It can be borrowed without limitation if the terminal is installed with an application capable of web browsing.

The communication network 70 connects the data providing apparatus 10, the operator terminal 30, the user terminal 50, and the creator terminal 51. In the present invention, the communication network 70 is not limited to a wired or wireless mode in its driving method. Therefore, a wired network such as a LAN (Local Area Network), a Bluetooth, a WiFi, (Wibro), satellite communications, and the like.

FIG. 2 is a block diagram of a data providing apparatus for disease mechanism research according to an embodiment of the present invention. Referring to FIG.

2, a data providing apparatus 200 according to an embodiment of the present invention includes a data request receiving unit 210, a data attribute determining unit 220, a data searching unit 230, a database group 240, A determining unit 250, a data providing unit 260, a user terminal 270, and a creator terminal 280. And an operator terminal 290.

The data request receiving unit 210 receives a data request from the user terminal 270. The user terminal 270 is a device that enables a user to access the data providing apparatus 200 and can be connected to the data providing apparatus 200 through various wired and wireless networks. The user terminal 270 is a terminal equipped with a browser application that allows a user to perform web browsing. The present invention can be applied to a user terminal 270, And does not limit the type to any particular one.

Here, the data request refers to a signal for determining whether data stored in the database group 240 of the data providing apparatus 200 is in accordance with a condition specified by the user, and transmitting the result to the user terminal 270 do.

The data attribute determination unit 220 determines the search attribute of the data based on the target material and / or the condition included in the data request. Here, the search attribute is determined from the conditions included in the data request, that is, from the target substance, the type, the kind of the processing method, the generation time, and so on. The material-related attributes are those related to the subject matter itself, including the position, type, etc. of the subject matter, among the attributes that can be deduced from the condition, and the processing-related attribute Processing method, whether it is processed, the generation time, and the like.

Here, the condition included in the data request may include at least one of the type of data, the kind of the processing method, and the generation time, and the attribute of the data to be provided includes the type of the data, the kind of the processing method, And the number of citations of the data.

The target substance of the data refers to the substance that is the subject of the data requested by the user and is a substance to be subjected to the experiment such as' pancreatic cancer tissue (78 years old, male, Stage Ⅲ, Grade 4) Means material information for a sample. In addition, the subject matter of the data may include a wide range of already well-known classifications in academia. For example, when a user makes a data request through the user terminal 270 and inputs 20 essential amino acids, the target substance of the data requested by the user can be all 20 essential amino acids.

Here, the data can be classified into the next generation sequencing method such as whole genome sequencing, whole exome sequencing, and RNA sequencing. Which is one of the analysis objects. For example, the data type for RNA Sequencing is RiboNucleic Acid.

Here, the type of data processing method refers to information on a method of generating data. More specifically, the type of data processing method refers to a type of tool for analyzing using a next-generation sequencing analysis technique. In particular, the type of data processing method may include the name of the process or process. Examples of methods of processing data include genomic techniques such as whole genome sequencing (WGS), whole exome sequencing (WES), microarray (microarray) (MALDI-TOF, Liquid Chromatography-Mass Spectrometry (LC-MS), and Molecular-Assisted Laser Desorption-Ionization Time-of-Flight Mass spectrometry (NMR), liquid chromatography-mass spectrometry (LC-MS), gas chromatography (mass spectrometry) - GC-MS (Gas Chromatography-Mass Spectrometry).

The data processing method may include the following analysis method.

- (A) Dielectric data: Whole genome, exome sequence data and analysis data (can be processed by processing / processing methods such as variant calling, assembly, CNV, SV,

- (B) Transcript data: RNA-seq, miRNA-seq sequence data and analysis data (can be processed by processing / processing methods such as quantification, variant detection, alternative splicing,

- (C) Follow-up genomic data: ChIP-seq, Histone modifications, DNA methylation analysis data and visualization data

- (D) Network analysis and signaling control and Pharmaco-Genomic data: Network reasoning, subnetwork and module analysis, pathway identification, transcription control, protein interaction, functional network, disease-drug-genome information data mining etc.

- (E) Meta-genome data: microbiota, phylogeny analysis, etc.

Data relating to the genome are obtained for different purposes. In particular, it is possible to confirm the base variation of the genome using the genome data, to confirm the expression of the genome using the transcript data, and to use the genome data To identify genetically altered genomes.

Here, whether or not the data is processed is whether the data is obtained directly from the target material in generating the data or whether the data can be obtained after performing a special process (experiment, separation, extraction, filtration, etc.) .

More specifically, the processing of data is based on the primary experimental data processed by the next-generation base analysis technique, and is based on a simple algorithm for searching for a mutated gene sequence in a nucleotide sequence to be decoded, Advanced information such as copy-number variation (CNV), single nucleotide polymorphism (SNP), and so on, can be found by using software that operates on a single nucleotide polymorphism Is extracted or extracted.

MutSig (Mutation Significance) may be used as software for selecting a gene variation, and Gistic may be used as software for selecting a gene from a periodic copy number change, And it is not outside the scope of the present invention to process the data through other software if the same algorithm can be performed.

The data providing apparatus for the disease mechanism research according to the embodiment of the present invention can provide both the primary experimental data and the data obtained by processing the primary experimental data. That is, the data (raw data) obtained immediately after the object substance through the item of whether or not the data is processed, the data (raw data) obtained after performing a special process (experiment, extraction, separation, filtration, Data). ≪ / RTI >

In other words, the type of data processing method is a condition that a user can input through a user terminal when a specific process or process applied to the data is clearly known, and whether or not the data requested by the user is processed is applied to the data Even if you do not know the specific process or process, you can use it as a condition to search for appropriate data even if you know the characteristic that the characteristic of the data greatly changes before or after the special process.

Here, the generation time of the data refers to the time when the data is generated. The data requester (user) can request data by limiting the generation time of data.

For example, if the user requests data generated six months in advance, the user inputs data in the date range from the data providing device 200 to the user terminal 270 by inputting the date range six months before the current date Can be provided.

Here, the number of citations of data means information on the number of times the data is cited in the paper. The number of citations of the data can be a measure of how deeply the data is being studied. The data attribute determination unit 220 may be connected to an external server that provides paper related information in order to collect the latest information on the number of citations of data through a wired / wireless network.

The attributes of the data to be provided to the user terminal 270 (hereinafter, data attributes) are determined based on the conditions included in the data request as described above, , And may include a substance-related property or a process-related property. The data attribute to be finally provided can be a table type.

The data attribute of the table type determined by the data attribute determination unit 220 may be input as an input value of the data search unit 230 to be described later. It depends on the number. In addition, the data attributes (material-related attributes or process-related attributes) can be determined more than once for each condition included in the data request.

The data retrieving unit 230 retrieves data corresponding to attributes (material-related attributes or process-related attributes) of data requested by the user. More specifically, the data retrieving unit 230 receives a data attribute from the data attribute determining unit 220 and extracts a data attribute (a substance-related property or a process-related property) from the data stored in the database group 240 The corresponding data can be retrieved.

The database group 240 stores various data that the data providing apparatus 200 can provide to the user terminal 270. Various data stored in the database group 240 may have an identification code unique to each data in order to facilitate the search in the data searching unit 230. [

The database group 240 may include a plurality of small databases in order to store each data classified according to characteristics. Referring to FIG. 2, the database group 240 includes four small databases, and the present invention does not limit the number of small databases that can be included in the database group 240 to a specific number. Therefore, The database group 240 may include fewer or more small databases than four.

As an alternative embodiment, each small database included in database group 240 may include a processing unit (not shown). The processing unit (not shown) processes the raw data and processes it as processed data when the data stored in the small-scale database is processed by a specific method and the nature of the data or the research value is changed. When processing data (raw data) is processed every time a user requests data with a processing unit (not shown) in a small database, it is more efficient to store the raw data and processed data in a small database It can be more beneficial in utilization.

The price determining unit 250 determines the price of data requested by the user in consideration of the information on the creator of the data retrieved from the data retrieving unit 230, the time required for the generation, resources required for generation, and the like. In another embodiment, the pricing unit 250 includes a first pricing unit (not shown) for determining the initial price of the data on the basis of the information about the producer of the retrieved data and / or the attributes of the data, A second price determining unit that calculates a rate of price change considering a required time and a resource required for generation and determines a final price of the data in consideration of both the initial price and the rate of change in price.

The first pricing unit may determine the initial price of the data based on the material-related attributes among the attributes of the retrieved data. The first pricing decision unit compares the data of the target substances and can charge a higher price for a target substance that is difficult to obtain because it is a rare cancer tissue. It can be tied.

Here, the information on the creator of the data is information on the person who generated the data, and may include both the status at the time of generation of the data and the status of the user received the data request. Here, the position may include information such as a career or a career, and may include class information corresponding to a career or a career. In other words, the status of the constructor with 9 years of experience is higher than that of the constructor with 3 years of experience, and the status of the constructor who is a researcher may be higher than that of a constructor with a career independent of the research. In other words, the higher the status of a creator with a career to do cancer-related research and clinical work, such as a doctor or a researcher, and the higher the level of the creator with that career. Here, the status of the constructor includes the final educational background of the constructor, the major of the constructor, the profession of the constructor, the number of papers of the constructor, the prize winning history of the constructor, or the final academic ability of the constructor, the major of the constructor, The number of papers, and the awards of the creators.

The price determining unit 250 can determine the price of the data by considering only the status when generating the data. For example, the price determination unit 250 may set a higher price for data having a high status of the data producer at the time of generating the data (hereinafter, the first case)

As an alternative embodiment, the aggregate rank of the constructors used to determine the price of the data may be updated by the user or administrator. In addition, the position of the creator can be determined by summing the first class calculated through the past career or occupation of the creator, and the second class calculated by the user or the manager. At this time, the status of the creator can be calculated by weighted averaging of different weights for the first and second classes.

For example, if the overall grade of the constructor initially assigned reflects a lot of elements of the creator's job, the user can calculate a new overall grade based on the number of the cumulative number of papers of the constructor or the award winner of the constructor, So that the user can retrieve the desired data.

The price determination unit 250 can determine the initial price of the data in consideration of both the status and the current status when the producer is created. In the case where the status of the data producer is low at the time of generating the data but the status of the data producer is high at the time of receiving the data request of the user (hereinafter, the second case), the pricing unit 250 The initial price of the data can be determined to be higher than the price of the data generated through the position at the time of creation, taking into account the current status of the creator who has made more research achievements.

In another embodiment, the pricing unit 250 may determine the initial price of the data for the data of the producer whose current position is not searched for at a price lower than the price of the data calculated through the position at the time of generation. For example, if the status of the data producer is low at the time of generating the data and the status of the data producer is low or is not searched at present (hereinafter, the third case), the pricing decision unit 250 Considering the fact that the current position of the constructor is not searched, it can be determined that the creator is willing to study, and in consideration of this, the initial price can be determined at a slightly lower price of the data.

The price determining unit 250 can differentially determine the price of the data by at least one of the status at the time of data generation of the person who generated the data and the current status in which the data request of the user is received as described above. The price determining unit 250 may be connected to an external personal information providing server (not shown) through a wired or wireless network in order to check information on the current status of the data producer in real time.

As an alternative embodiment, the pricing unit 250 may determine whether the user requesting the data through the user terminal 270 is the same as the creator that generated the data, between the user requesting the data through the user terminal 270 and the data requested by the user The rate of change in the price of the data may be determined in consideration of at least one of the relevancy of the data. Here, the relevance between the user requesting the data through the user terminal 270 and the data requested by the user is determined by the user requesting the data through the user terminal 270 to generate the data requested through the user terminal 270 Contribution can be degree. For example, assuming that the producer of the specific data Z is A, B, C, three or more persons, and the degree of contribution to the generation of the data is high, medium and low, The decision unit 250 decides that the data requesting party and the data requesting party are identical to each other in C, determines the data price by applying a high discount rate, or generates the data requesting the data. However, since the contribution is low, Data rates can be determined by applying a low discount rate.

As an alternative embodiment, the information about the creator of the data may include the level information of the creator. Here, the level information of the producer can be determined in consideration of at least one of the number of data generated by the producer, the cumulative sales amount of the data generated by the producer, and the income from the data generated by the producer. In another embodiment, the pricing unit 250 may determine the rate of price change of the data in consideration of whether or not the data is processed. For example, if raw data for a target material A and processed data for a target material A are present, the pricing section can determine the price change rate of the processed data to be higher than the rate of price change of the raw data. Depending on the price of the differential data, a user who purchases only raw data may purchase all the raw data and processed data, or settle a lower amount than the user who purchases only processed data.

In another embodiment, the pricing unit 250 may determine the rate of price change of the data in consideration of the time required to generate the data. The price determining unit 250 can determine the rate of price change of the data to be higher as the time required for generating the data is longer. The time required to generate the data may vary depending on the method of generating the data and the capacity of the creator, so that the time can be displayed instead of the fixed time. At this time, besides the displayed temporal range, the maximum time and minimum time required to generate data and the average time for generating data of the uploaders of the uploaded data may be additionally displayed. For example, in response to a data request for requesting data processed by the assembly method among the dielectric data, the pricing unit 250 determines the resources (time, cost, etc.) necessary for processing the dielectric data by the assembly method, The rate of price change of the data can be determined. In addition, in response to a data request requesting data processed by the CNV method among the dielectric data, the pricing unit 250 allocates resources (time, cost, etc.) necessary for processing by the CNV method, differently from processing the dielectric data by the assembly method , It is possible to determine the price change rate of the data. Accordingly, the data providing apparatus according to the embodiment of the present invention can differentially determine the price for the requested same kind of data according to the data processing method included in the request of the requester.

In another embodiment, the pricing unit 250 may determine a rate of price change of data in consideration of resources required for generating data, for example, cost. The pricing unit 250 may set a higher price change rate for the data with a large amount of necessary resources for generating the data.

In another embodiment, the pricing unit 250 can determine the rate of price change of the raw data and the processed data according to the raw data and the initial data required to generate the processed data. Here, the initial data needs to be data that can be used for qualitative and quantitative determination of the purity of the data or the analysis result so that the price of the data can be clearly determined.

The data providing unit 260 provides display information including the data requested by the user and the price of the data determined by the price determining unit 250 to the user terminal 270. The user can confirm the price of the data and data included in the display information, and decide whether or not to proceed with the payment.

The indication information provided to the user terminal 270 may include at least one of the effects that can be obtained through the data provided to the user terminal 270 and some contents included in the data provided to the user terminal 270. [

Some of the data included in the data requested by the user means data provided in a preview format so that the user can know immediately if the user belongs to the field handling the data. The user can check some contents included in the data and utilize them to decide whether or not to purchase.

Table 1 is an example of display information output through the display unit of the user terminal 270.

Analyzing Table 1, it can be seen that the user requested the data providing device to provide the raw D & A data of the pancreatic cancer tissue data generated on November 13, Referring to Table 1, the user is expected to be able to identify cancer drug development and biomarkers of pancreatic cancer using raw D & A data.

Referring to Table 1, there are three producers that generated raw D & A data, and their status at the time of generation of raw D & A data and current status are different, and the contribution of the three producers is also different. In addition to the above-mentioned contents, the user confirms the substance, time, user level, price of the data, and data preview (a part of the data) required for data generation through the display information as shown in Table 1, Can be determined.

Referring to Table 1, the price of the data requested by the user is determined to be 1,600,000 won. This price includes the resources (difficulty, time, cost, etc.) required for generating the requested data, information of the producer that generated the data, And if the user level is higher than 3, the user may purchase the data at a discount rate of less than 1.6 million won. The price can be calculated in consideration of the kind of requested data and the method of obtaining each data (processing, processing method). At this time. The price according to the data acquisition method (processing, processing method) may be proportional to the degree of difficulty set according to the resources, time, etc. required for generation.

The data providing unit 260 may transmit the data requested by the user to the user terminal 270 when the user completes the settlement through the user terminal 270. In an alternative embodiment, when the amount of data requested by the user is too large to be transmitted over a wired or wireless network, data requested by a user may be transmitted to a hard disk for delivery (not shown) connected to the data providing apparatus 200 have. The user can receive the data requested by the user through the user terminal 270 by receiving the hard disk for distribution offline.

As an alternative embodiment, the condition included in the data request may include at least one of the target material, the type of the data requested by the user, the kind of the processing method, the budget range of the data besides the generation time, and the total limit amount.

The user can also transmit information about the amount that the user can make payment while requesting the data through the user terminal 270 so that the data providing apparatus 200 can provide the data considering the information about the amount . According to this alternative embodiment, the data providing unit 260 extracts a part of the data retrieved by the data retrieving unit 230 in consideration of the minimum or maximum amount included in the budget range of the data, Or extracts one or more pieces of data retrieved by the data retrieving unit 230 so that the total of the prices of the extracted data does not exceed the total limit amount, and provides the extracted data to the user terminal 270 (261).

In an alternative embodiment, the data request receiver 210 may receive a search request containing the first pathological data from the user. In addition, the data request receiving unit 210 may receive a search request including the genome-related data. The search request is received via various user inputs and may include biological data as well as pathological data. In the case of a search request including pathological data, the data property determination unit 220 may extract the type of gene related to the pathological data. For example, the data attribute determination unit 220 may extract the types of genes associated with gastric cancer, which are pathological data.

The data attribute determination unit 220 may determine the type of the gene corresponding to the search request and another attribute of the object in consideration of the pathological data as well as other conditions included in the search request. In the case of the search request including the genome-related data, the data attribute determination unit 220 may determine the attribute of the search target from the genome-related data in consideration of the type of the data included in the search request. For example, in response to a search request including breast cancer, which is a disease, the data attribute determination unit 220 extracts an Estrogen Receptor (ER) gene, and the data search unit 230 searches for a subject You can search. The data search unit 230 can search for the mutation type and the mutation type for the corresponding gene of the searched object. Also, in response to a search request including lung cancer, which is a disease, the data attribute determination unit 220 extracts the EGFR gene, and the data search unit 230 can search for the object in which the mutation has occurred with respect to the gene. The data search unit 230 can search for the mutation type and the mutation type for the corresponding gene of the searched object.

The data attribute determination unit 220 extracts the first gene as a gene related to the first disease at the first time point and extracts the first gene at the second time point after the predetermined time from the first time point, For the same disease as the disease, the first gene and the other second gene can be extracted. That is, the data attribute determination unit 220 can determine the determined data at the first point of time and the determined data at the second point of time by conducting a lot of research over time. That is, the user can receive different data according to the time of requesting the data. Accordingly, the data providing apparatus 200 according to the embodiments of the present invention provides data that can reflect advances in science and medical technology.

The data attribute determination unit 220 may cause the disease, treatment, and prescription history to search for the same object in response to a search request including treatment for diseases and diseases, prescription details, and the like. That is, the data attribute determination unit 220 may generate a retrieval expression for retrieving the object having the same disease, treatment, and prescription history.

The data searching unit 230 searches the degree of expression of each gene included in the type of the gene related to the first pathological data, searches for biological data expressed by the expression level of each gene, Searches for a second object, retrieves a record of second biological data and second pathological data linked to the record corresponding to the second object.

The data providing unit 260 provides a record of the second biological data and a record of the second pathological data to the terminal of the user.

The price determining unit 250 may determine a charge to be charged to the user based on the appropriateness of the second biological data or the completeness of the second pathological data. In addition, the price determination unit 250 may transmit the settlement processing for the charged amount to the user terminal. Here, the suitability of the biological data and the completeness of the pathological data will be described in detail in FIG.

The creator terminal 280 is a kind of user terminal used by an expert capable of generating data of the same kind as the data stored in the data providing device 200. The creator terminal 280 essentially includes the functionality of the user terminal 270. The creator terminal 280 may include a function of allowing the operator to update the data stored in the data providing apparatus 200 through the operator terminal 290 by requesting the operator terminal 290 to upload data. The creator terminal 280 may be connected to the data providing apparatus 200 through various wired / wireless networks and may be connected to the operator terminal 290.

The operator terminal 290 connects to the data providing apparatus 200 and performs maintenance and repair of the data for updating the data stored in the data providing apparatus 200 and for operating the data providing apparatus 200. The operator terminal 290 may provide an identification code to the user terminal 270 and the creator terminal 280 to distinguish the user terminal 270 and the creator terminal 280 from each other. The operator terminal 290 can make a data upload request only to the creator terminal 280 having an identification code capable of making an upload request to secure the quality and reliability of data that can be stored in the data providing apparatus 200 .

The data providing apparatus 200 can store data in a structure of data as shown in FIG. The structure of the data is described below. The non-digital data group 310 is a part in which human behavior is intervened and an experiment is performed and data is calculated. The non-digital data group 310 includes human tumor tissues A1, D2, A2, A3, A5 < / RTI >

The database group 330 includes data stored in the data providing apparatus according to the present invention and includes a DENA small database 331, an ANA small database 333, a protein small database 335, a small database 337 ).

A3-1, A4-1, A5-1) of the human tumor tissue (A1) as an example of data that can be provided to the user terminal (270) by the data providing apparatus (200) . In order for the data on human tumor tissue (A10) to be meaningful data to the researcher, it is necessary to extract the derivative from human tumor tissue and to apply the extracted genetic material (A2, A3, A4, A5) It is necessary to generate a large amount of raw data (A2-1, A3-1, A4-1, A5-1) by applying a choreography technique.

In the process of generating large-volume raw data (A2-1, A3-1, A4-1, A5-1), not only the first human tumor tissue (A1) is annihilated, but also the foreign body tissue (A1) A2) require enormous cost, large-volume raw data (A2-1, A3-1, A4-1, A5-1) are difficult to collect and have a limited number of characteristics.

DNA (DeoxyriboNucleic Acid) (A2), RNA (RiboNucleic Acid) (A3), Protein (A4), Metabolites (A5) for use in research from human tumor tissues (A1) Can be extracted. In the case of D & A extract (A2), genomic techniques such as whole genome sequencing (WGS) and whole exome sequencing (WES) Gene mutation data) can be generated.

In the case of the RNase A extract (A3), raw RNE data (A3-1, transcript expression data) can be generated by applying a microarray or RNA sequencing, which is a transcription system technique .

In the case of protein extract (A4), Matrix-Assisted Laser Desorption-Ionization Time of Flight (MALDI-TOF), liquid chromatography-mass spectrometry (LC-MS) Quantitative, qualitative raw protein data (A4-1) can be generated.

In the case of the metabolite extract (A5), the metabolism techniques such as nuclear magnetic resonance-mass spectrometry (NMR-MS), liquid chromatography-mass spectrometry (LC-MS) Quantitative, qualitative metabolite data (A5-1) can be generated by techniques such as gas chromatography-mass spectrometry (GC-MS).

The gene mutation data (A2-1), transcript expression data (A3-1), protein data (A4-1), and metabolism data (A5-1) calculated through the above-described process are used as Omics data or It can be referred to as large-volume raw data and can be used by researchers studying human tumor tissue (A1) to analyze the human tumor tissue.

The large-volume unprocessed data calculated in the above manner is digitally processed and stored in the database group 330 of the data providing apparatus, and can be further processed and provided to the user at the request of the user.

The large-volume raw data A2-1, A3-1, A4-1, and A5-1 of the human tumor tissue A1 are processed by processing corresponding to each raw data included in each of the small databases 331, 333, 335, The processed data can be processed by the processing units 3311, 3331, 3351, and 3371 to become the large capacity processed data A2-2, A3-2, A4-2, and A5-2. For example, large-scale processed data (A2-2, A3-2, A4-2, A5-2) of human tumor tissue (A1) includes various kinds of data such as anticancer drug development data, cancer drug reprocessing data, A biomarker may be included.

As described above, the large-capacity processed data can be deleted from the small-scale database after being provided to the user at the request of the user. 3, the data of the data providing apparatus is limited to the data for the human tumor tissue for convenience of explanation of the raw data and the processed data. Therefore, in FIG. 3, the data on the human tumor tissue may be changed to other kinds of data It is applicable.

4 is a flowchart illustrating a data providing method for disease mechanism research according to another embodiment of the present invention.

The user terminal 410 transmits a data request to the data providing apparatus 430 (S410). The data providing apparatus 430 determines a data attribute based on the condition included in the data request (S420).

The data attribute is determined based on the conditions included in the data request, and may be determined as one or more values, each of the conditions included in the data request being a feature. The data attribute to be finally provided can be a table type.

The data providing device 430 retrieves data corresponding to the data attribute (S430). The operation of S430 is the same as that of the data retrieving unit, and thus a detailed description thereof will be omitted.

The data providing device 430 determines the price of the data as the metadata of the retrieved data (S440). The operation of S440 is the same as that of the pricing unit, and a detailed description thereof will be omitted.

The data providing device 430 provides display information including data and data prices to the user terminal 410 (S450).

5 is a flowchart illustrating a data providing method according to another embodiment of the present invention.

The user terminal 510 transmits a data request to the data providing apparatus 530 (S505). The data providing apparatus 430 determines a data attribute based on the condition included in the data request (S510).

The conditions included in the data request may include at least one of the target substance of the data requested by the user, the kind, the kind of the processing method, the generation time, the price range of the data the user can settle, and the total limit amount.

The data attribute is determined based on the condition included in the data request, and may be a table type having each condition included in the data request as a feature.

The data providing apparatus 530 retrieves data corresponding to the data attribute (S515). The data providing device 530 may determine the price using the metadata of the retrieved data and may differentially adjust the determined price (S520).

The meta data of the retrieved data may include information on the data creator, time required for data generation, and resources necessary for data generation, and the information on the data creator may include the status of the data creator at the time of data generation and the current status . The data providing apparatus 530 may determine the price by using only one of the meta data of the data. For example, the price of the data can be determined by considering only the status of the producer of the data.

Here, the status of the constructor includes the final educational background of the constructor, the major of the constructor, the occupation of the constructor, the number of papers of the constructor, the awards of the constructor, or the final academic achievement of the constructor, the major of the constructor, Number, and the creator's awards.

If the user who requested the data and the creator that generated the data are the same in step 520 or the user who requested the data contributes to the generation of the data, the price of the data may be adjusted to a lower price by reflecting the contents.

In an alternative embodiment, level information may be included in the information about the generator in step 520. [ The level information of the generator can be determined in consideration of at least one of the number of data generated by the generator, the cumulative sales amount of the data generated by the generator, and the income from the data generated by the generator. A high level creator can benefit from the fact that when the data is created and uploaded to the data providing apparatus according to the present invention, the uploaded data is determined as a high selling price or a certain rate discount can be received when data is provided from the data providing apparatus Can enjoy.

The data providing apparatus 530 may compare the final determined price with the settlement amount input by the user in step 520 and determine data to be provided to the user terminal (S525).

The data providing device 530 may provide the display information including the price of the data and the data to the user terminal 510 (S530).

The user confirms the display information through the user terminal 510 and may transmit the payment information to the data providing apparatus 530 through the user terminal 510 after determining to purchase the data (S535).

The data providing apparatus 530 may confirm the authenticity of the payment information received from the user terminal 510 and approve the payment (S540).

The data providing apparatus 530 determines in what manner the data requested by the user is to be provided (S545).

If the user requests to transmit data to the user terminal 510 via the wired or wireless network or if the capacity of the data requested by the user does not exceed the preset reference capacity, And transmits the requested data (S550).

When the user requests not to transmit data to the user terminal 510 via the wired / wireless network because of security or the like, or when the capacity of the data requested by the user exceeds the preset reference capacity, the data providing device 530 transmits Compresses and encrypts the data on the hard disk to be transmitted (S555). In step 555, the hard disk storing the data requested by the user is directly transferred to the user offline, so that the user can be provided with the data requested to the data providing apparatus 530.

FIG. 6 is a flowchart illustrating a data providing method based on a data providing apparatus for disease mechanism research according to another embodiment of the present invention. Referring to FIG.

In order to compare with FIG. 4 and FIG. 5 described above, FIG. 6 illustrates a data providing method based on the data providing apparatus.

The data providing apparatus receives a data request from the user terminal (S610).

The data providing apparatus determines a data attribute based on the condition included in the data request (S620). The conditions included in the data request may include at least one of the target substance of the data requested by the user, the kind, the kind of the processing method, the generation time, the price range of the data the user can settle, and the total limit amount.

The data providing apparatus retrieves data corresponding to the data attribute (S630).

The data providing apparatus may determine the price as meta data of the searched data and adjust the determined price differentially (S640).

The meta data of the retrieved data may include information on the data creator, time required for data generation, and resources necessary for data generation, and the information on the data creator may include the status of the data creator at the time of data generation and the current status . If the user who requested the data and the creator that generated the data are the same in step 640 or the user who requested the data has contributed to the generation of the data, the price of the data may be adjusted to a lower price by reflecting the contents. Also, as an alternative embodiment, level information may be included in the information about the constructor in step 640, so that a high-level constructor can receive discounts on data purchase.

In step S650, the data providing apparatus compares the final determined price with the settlement amount input by the user in step 640 and determines data to be provided to the user terminal.

The data providing apparatus may provide display information including the price of data and data to the user terminal (S660). In step 660, the data providing apparatus may request the electronic settlement while providing the display information to the user terminal.

The data providing apparatus receives the payment information from the user terminal, and confirms whether payment has been made through a proper procedure (S670).

The data providing apparatus provides the data requested by the user according to the providing method desired by the user (S680). In step 680, the data providing apparatus may provide the data requested by the user in consideration of the size of the data requested by the user, in addition to the method of providing the data requested by the user.

For example, if the user requests to transmit data to the user terminal via the wired or wireless network, or if the capacity of the data requested by the user does not exceed the preset reference capacity, the data providing device can transmit the data requested by the user to the user terminal have.

As another example, when the user requests to not transmit data to the user terminal via the wired / wireless network due to security or the like, or when the capacity of the data requested by the user exceeds the preset reference capacity, It is possible to compress and encrypt the data on the disk and transmit it. In step 680, the hard disk storing the data requested by the user is directly transferred to the user offline, so that the user can receive the requested data to the data providing apparatus.

7 is a diagram for explaining a process of generating data from a living cell.

The data providing apparatus 200 can generate the biological data acquired from the living cell D1 of the object as the first record R1. Here, the living cells are not limited to cells but may include tissues, saliva, blood, urine, body fluid, proteins (protein, DNA, RNA) . The data providing apparatus 200 may generate the pathological data D2 for the object as the second record R2.

The record R1 of the biological data corresponding to the object is data obtained by processing the cell by a predetermined processing method and may include the arrangement of the genes, the degree of expression of each gene, whether or not the gene is expressed, and whether mutation has occurred. Herein, examples of the treatment method include genomic techniques such as whole genome sequencing (WGS), whole exome sequencing (WES), microarray or RNA sequencing (RNA Sequencing, Matrix-Assisted Laser Desorption-Ionization Time of Flight (MALDI-TOF), Liquid Chromatography-Mass Spectrometry (LC-MS), Nuclear Magnetic Resonance- (NMR-MS, Nuclear Magnetic Resonance-Mass Spectrometry), Liquid Chromatography-Mass Spectrometry (LC-MS), Gas Chromatography-Mass Spectrometry Can be. 7, the first record R1 includes the sequence information (op1-1) of the genes obtained from the living cells, the expression level (op1-2) of each gene, the expression level (op1-3 ), The presence or absence of a mutation (op1-4), and the like. Biological cells of a subject have the same gene sequence depending on the species. Because the genetic characteristics of the subject are different, the expression and expression level of each gene will be different. The first record R1 may include the name of the dielectric, the position in the dielectric, the original value, the modification value, the type of mutation, the position in the exon, the specificity of the gene, and the like. The original value refers to the value of the nucleotide sequence of the corresponding genome and means the nucleotide sequence of a normal person. The change value means the nucleotide sequence of the subject. The first record (R1) may further include information indicating a difference between the nucleotide sequence of the normal person and the nucleotide sequence of the subject, and the difference in the expressed protein. Here, the mutation type refers to one of removal, modification, and insertion of some base sequences in the base sequence, and even if the base sequence is changed, the base sequence may not be mutated if there is no difference in the expressed protein. The second record R2 includes pathological data such as diseases and diseases associated with the object, and includes a generation time (op2-1) of each item generated with respect to the object and detailed information (op2-2 ). In addition, the second record R2 may further include information related to the prescription, a result obtained through the treatment history, and the prognosis, while providing a prescription and treatment history for the disease associated with the subject. The second record R2 contains data obtained from a server of a medical institution (hospital, pharmacy, etc.).

8 and 9 are flowcharts of a data providing method for disease mechanism research according to embodiments of the present invention.

Referring to FIG. 8, a method of providing data according to embodiments of the present invention includes a data collection step S801, a data primary analysis step S802, a method selection step S803, a data acquisition step S804, Step S805.

In S801, the data providing apparatus 200 may collect pathological data on the living cells and the one or more subjects obtained from the one or more subjects. Herein, the object refers to a living organism such as a person, an animal, a plant, etc., wherein the living cell is a cell obtained from a subject, and may include all cells of any kind. Herein, the pathological data is related to diseases, diseases, and the like related to the subject, and may include data collectively including diagnosis, treatment, treatment, and progress of the subject.

In step S802, the data providing apparatus 200 can primarily analyze the living cells. At this time, considering the amount of living cells, the data providing apparatus 200 can primarily process the living cells so as to acquire genome data and transcript data. The data providing apparatus 200 analyzes the biological cell using a processing method for obtaining dielectric data capable of confirming a base variation of the dielectric and a processing method for acquiring transcript data for confirming the expression of the dielectric can do. The data providing apparatus 200 can analyze living cells in consideration of the appearance of the living cells, the size of the living cells, the storage state, the pathological data of the target, and the like. The data providing apparatus 200 can primarily analyze living cells by performing predetermined processing on the living cells. For example, the data providing device 200 can primarily analyze biomolecules by applying heat to DNA contained in living cells and treating double-stranded DNA with a single strand. The data providing apparatus 200 can primarily analyze the living cells by amplifying a small amount of DNA with DNA having the same amount of base sequence.

In S803, the data providing apparatus 200 can select the processing method for processing the living cells using the result of the primary analysis. At this time, the processing method may be one or more. At this time, the selection criteria of the processing method may vary depending on the price, the time, and the data to be acquired.

Since living cells can not be meaningful data in themselves, a process of processing living cells is necessary in order to become meaningful data. Biological cells can be processed through sequencing. There are many types of DNA sequencing, and the costs, time, etc. required to process each sequence vary.

The data providing apparatus 200 can analyze a living cell and extract a tissue, an organ, and the like related to the living cell. The data providing apparatus 200 can determine a treatment method of a living cell in consideration of a tissue, an organ type, a storage state, a size, and the like associated with the living cell.

The data providing apparatus 200 may determine a processing method of processing the living body cells by using pathological data of the subject of the living body cells. The data providing apparatus 200 can determine the treatment method of the living cells according to the species of the target of the living cells. Species of a subject of a living cell may be analyzed by a living cell or may be determined by an administrator.

The data providing apparatus 200 can determine a processing method of processing the living body cell using other information (sex, age, age, habitat, residence, etc.) of the subject of the living body cell.

In step S804, the data providing apparatus 200 processes the biological cells by the above-described processing method, thereby determining the gene alignment of the genes of the first subject of the living cells and the degree of expression of each gene based on the biological data . The data providing apparatus 200 can determine the arrangement of the genes of the subject according to the species of the subject of the living cell. For example, when the subject of a living cell is a person, the data providing apparatus 200 can classify the genes included in the subject of the living cell according to a gene sequence of a human, and generate the classified information as biological data. In addition, the data providing apparatus 200 may further analyze whether or not each gene is expressed or mutated by analyzing the living cells.

In step S805, the data providing apparatus 200 generates and stores the biological data and the pathological data as respective records, links records corresponding to the first object and records of the biological data, A corresponding record, and a record of the pathological data may be concatenated and stored. Here, a record of biological data is formed in the form of an array having two or more rows, and may include data corresponding to the type of gene and the degree of expression of each gene. A record of pathological data is also organized in the form of an array having two or more rows, and may be sorted in chronological order or categorized into the same disease or disease.

Referring to FIG. 9, a method of providing data according to embodiments of the present invention includes receiving a search request (S901), extracting a gene type (S902), retrieving data (S903) (Step S904), a data providing step (step S905), a charge amount determination step (step S906), and a payment processing step (step S907).

In step S901, the data providing apparatus 200 receives a search request including the first pathological data from the user. The search request is received via various user inputs and may include biological data as well as pathological data.

In step S902, the data providing apparatus 200 extracts the types of genes associated with the first pathological data. The data providing apparatus 200 extracts the types of genes associated with gastric cancer, which are pathological data. The type of gene involved depends on the type of pathological data.

In step S903, the data providing apparatus 200 searches the degree of expression of each gene included in the type of the gene related to the first pathological data, and searches the biological data expressed by the degree of expression of each gene.

 In step S904, the data providing apparatus 200 searches for a second object providing the biological data, and records a second biological data and a second pathological data linked to the record corresponding to the second object. At this time, the data providing apparatus 300 can extract a target object having biological data and / or pathological data that contains the most abnormalities, faults, mutations, among the searched data. Or data providing apparatus 200 extracts a target object in which the difference between the state of the past object and the state of the current object is the largest among the searched data and the state of the current object is cured and the biological data and / It is possible to extract the enemy data.

In step S905, the data providing apparatus 200 provides a record of the second biological data and a record of the second pathological data to the terminal of the user.

In step S906, the data providing apparatus 200 determines a charge to be charged to the user based on the appropriateness of the second biological data or the completeness of the second pathological data.

In step S907, the data providing apparatus 200 transmits a settlement process for the charge amount to the user terminal.

10 is a block diagram showing the structure of a data generation unit 201 that may be included in the data providing apparatus 200 for disease mechanism research according to embodiments of the present invention.

10, the data generation unit 201 includes a data collection unit 202, a primary analysis unit 203, a processing method selection unit 204, a data acquisition unit 205, and a data processing unit 206 can do.

The data collection unit 202 collects data related to one or more objects from one or more users. The data collection unit 202 may collect the living cells obtained from one or more objects and collect pathological data for each object.

The primary analysis unit 203 primarily analyzes biomolecules of the respective objects.

The processing method selection unit 204 selects a processing method for processing each object using the primary analysis result.

The data acquisition unit 205 selects a processing method for processing the living cells using the result of the primary analysis and processes the living body cells by the processing method so that the gene of the first subject of the living body cells And the degree of expression of each gene can be obtained as biological data corresponding to the living cells.

The data processing unit 206 generates and stores the biological data and the pathological data as respective records, connects records corresponding to the first object and records of the biological data, records corresponding to the first object, And a record of the pathological data may be concatenated and stored.

A record of the biological data may include data corresponding to the degree of gene expression and gene expression in the form of an array having two or more rows.

The pathological data may include at least one of a medical history of the first object, a treatment history of the first object, and a diagnosis history of the first object. The pathological data may further include constitution, health status, sex, occupation, genetic family history, etc. of the first subject.

In yet another embodiment, the data request receiver 210 may receive a search request that includes the first pathological data from a user. In order to process the received search request, the data search unit 230 may extract the type of the gene related to the first pathological data, and may search for each gene included in the type of the gene associated with the first pathological data And the biological data expressed by the expression level of each gene can be retrieved. The data retrieval unit 230 may search for a second object providing the biological data, retrieve a record of second biological data linked to the record corresponding to the second object, and a record of the second pathological data have. The data providing unit 260 may provide a record of the second biological data and a record of the second pathological data to the terminal of the user. In addition, the data providing unit 260 may determine a charge to be charged to the user based on the appropriateness of the second biological data or the completeness of the second pathological data, To the terminal.

The suitability of the second biological data may be determined through at least one of primitive factors of living cells, factors generated upon extraction, and factors generated during storage. More specifically, the appropriateness of the second biological data may be increased as the size and amount of living cells increase. The larger the living cells, the larger the amount of DNA that can be extracted. The suitability of the second biological data may be increased as the biological cells contain less impurities. The suitability of the second biological data can be determined as the storage state of the living cells. The appropriateness of the second biological data obtained from the stored biological cells under appropriate conditions is increased. The suitability of the second biological data may be determined by the accuracy of the method of processing the second biological data, the state of the living cells, the degree of destruction upon extraction of the living cells, the degree of deterioration during storage of the living cells, have. Can be set, calculated and measured based on the accuracy of the method of processing the second biological data. For example, it may be determined whether the method of processing the second biological data is up-to-date, taking into consideration at least one of the number of citations in a manuscript, the number of citations in a manuscript, have. In addition, the suitability of the second biological data can be determined through the type of organ in which the biological cells are collected, collected and obtained. Suitability of the second biological data can be determined in consideration of the relevance of pathological data of the organ in which the organism cells are collected, collected, and obtained. In other words, the appropriateness of biological data on organisms contained in pathological data, ie, diseased or diseased organs, can be set higher than otherwise have. The appropriateness of the biological data on the living cells can be determined in consideration of the collection organ of the living cells, the collecting time, the collected size, and the like. The adequacy of the biological data of biological cells can be determined by taking into account at least one of the collection organ of the living cell is the disease, the organ causing the disease, the collection time is the disease, the occurrence time of the disease, and the collected size. That is, the appropriateness of the biological data can be determined to be the case where the collected size is equal to or larger than a predetermined size.

When the state of the living cells is very good, the state exceeds a predetermined threshold, the living cells are not destroyed during extraction, the predetermined destruction rate is not exceeded, the living cells are not deteriorated during storage, When the set storage rate is exceeded, the suitability of the second biological data can be set to be very high, as the operator of the biological cell has a high degree of skill, that is, has a predetermined career experience or more.

The completeness of the second pathological data may be set in proportion to the time difference between the first input point and the last input point of the second pathological data. The second pathological data refers to social data obtained through the medical examination, diagnosis, and treatment history of the subject, and may include information on the medical staff who entered the diagnosis, diagnosis, and treatment history. The completeness of the second pathological data can be determined in consideration of the life span and age of the object. That is, the completeness of the accumulated second pathological data for a time period corresponding to the life of the object is set to be very high, and for a short period of time insufficient for the life of the object, for example, Completeness of the enemy data can be set very low. In particular, the completeness of the second pathological data can be set in proportion to the time difference between the first input point and the last input point of the second pathological data, and the time difference is set to a predetermined threshold time, , It can be set to a natural number of 1 or 100 so as to be almost perfect. In addition, the completeness of the second pathological data may be established, taking into account information about the user who generated the second pathological data. The completeness of the second pathological data may be calculated in consideration of whether the creator or creator of the second pathological data is a medical partial worker and the length of the career of the creator or creator of the second pathological data. Completeness of the second pathological data may be set higher when the creator or creator of the second pathological data is a medical part, or the longer the career of the creator or creator of the second pathological data. In addition, the completeness of the second pathological data may be determined in consideration of the final state of the object of the second pathological data. If the current state of the object is in a cured state, the completeness of the second pathological data can be determined to be very high.

The data providing apparatus 200 according to the embodiments of the present invention can measure the economic and social value of the provided data. In addition, through this, the biological data of the subject and the pathological data of the subject can be changed depending on the treatment method or the creator, even if they are the same subject.

The present invention can also be embodied as computer-readable codes on a computer-readable recording medium. A computer-readable recording medium includes all kinds of recording apparatuses in which data that can be read by a computer system is stored. Examples of the computer-readable recording medium include ROM, RAM, CD-ROM, magnetic tape, floppy disk, optical data storage, and the like. In addition, the computer-readable recording medium may be distributed over network-connected computer systems so that computer readable codes can be stored and executed in a distributed manner. In addition, functional programs, codes, and code segments for implementing the present invention can be easily inferred by programmers of the technical field to which the present invention belongs.

It is to be understood that the present invention is not limited to the above-described embodiments and the accompanying drawings, and that the scope of the present invention is defined by the appended claims, and that various changes, substitutions and alterations can be made hereto without departing from the spirit of the invention, It will be apparent to those skilled in the art that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention.

200: data providing apparatus 260: data providing apparatus
210: data request receiving unit 261:
220: Data attribute determination unit 270:
230: Data search unit 280: Creator terminal
240: Database group 290: Operator terminal
250:

Claims (6)

Collecting pathological data for the at least one subject and the bio-derivative comprising the gene obtained from the at least one subject;
(WGS), Whole Exome Sequencing (WES), Microarray (Microarray), or the like to obtain genome data that can confirm the genomic base mutation of the biological material. Analyzing or processing using at least one of a target sequence, a target sequencing, a Sanger sequencing, and an electrophoresis method;
Obtaining transcript data to confirm the expression of the genome Using at least one of the following methods: NGS, RNA Sequenicng, PCR, and electrophoresis Analysis or processing;
Wherein the data providing apparatus selects the processing method for processing the bio-derived material by using the pathological data of the subject of the bio-derivative and the species of the subject as a result of the analysis or processing, Obtaining biological data related to the gene according to the species of the first subject of the biological material by treating the biological material;
Wherein the data providing apparatus generates and stores the biological data and the pathological data as respective records, connects records corresponding to the first object and records of the biological data, records corresponding to the first object, Concatenating and storing a record of the pathological data;
Receiving the search request including the first pathological data from the user;
Extracting a nucleotide sequence of a gene associated with the first pathological data;
The data providing apparatus searches for the degree of mutation and expression of each gene included in the nucleotide sequence of the gene related to the first pathological data and searches for biological data expressed by the degree of mutation and expression of each gene;
Searching for a second object provided with the biological data, retrieving a record of second biological data and a record of second pathological data linked to the record corresponding to the second object; And
And transmitting a record of the second biological data and a record of the second pathological data to the terminal of the user.
The method according to claim 1,
A record of the biological data
A method for providing biological data for disease mechanism research comprising, in the form of an array having two or more rows, a gene sequence, and data corresponding to the degree of expression of the gene. The method according to claim 1,
The pathological data
A medical history of the first object, a treatment history of the first object, and a diagnosis history of the first object, the biological data for disease mechanism research. delete delete A data collector for collecting pathological data for the at least one subject and a bio-derivative comprising genes obtained from at least one subject;
(WGS), Whole Exome Sequencing (WES), Microarray, and Target Sequencing (Target Sequencing) to obtain genomic data that can confirm the base mutation of the above-mentioned bio-derived material. Next Generation Sequence Analysis (NGS) to obtain transcript data for analyzing or processing using at least one of the sequencing, Sanger sequencing, and electrophoresis methods and verifying the expression of the genome, A primary analysis unit for analyzing or processing using at least one of RNA Sequenicng, Polymerase Chain Reaction (PCR), and Electrophoresis;
The method according to any one of claims 1 to 3, wherein the result of the analysis or treatment is obtained by selecting a treatment method for treating the biological material by using pathological data of a target of the biological material or species of the target object, A data acquiring unit for acquiring gene alignment and degree of expression of each gene in accordance with the species of the first object of the living body derived from the biological data corresponding to the gene;
And generating and storing the biological data and the pathological data as respective records, connecting a record corresponding to the first object and a record of the biological data, and recording the record corresponding to the first object and the pathological data A data processing unit for connecting and storing records;
A data request receiving unit receiving a search request including a first pathological data from a user;
A data attribute determination unit for extracting a nucleotide sequence of a gene related to the first pathological data;
Searching for the degree of mutation and expression of each gene included in the type of the gene related to the first pathological data, searching for biological data expressed by the degree of mutation and expression of each gene, And a data retrieval unit for retrieving a record of second biological data and a record of second pathological data linked to the record corresponding to the second object,
A record of the second biological data and a record of the second pathological data are transmitted to the terminal of the user.

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