KR101951021B1 - UV blocking cosmetic composition having an antiperspirant function and preparing process for UV blocking agents using the same - Google Patents

Abstract

The present invention relates to a functional ultraviolet (UV) blocking cosmetic composition having an antiperspirant function and a process for preparing the ultraviolet screening composition using the same. The UV-blocking cosmetic composition having an antiperspirant function according to the present invention comprises glycopyrrolate An ultraviolet screening agent or an inorganic ultraviolet screening agent as an active ingredient.
The UV-blocking cosmetic composition having the anti-perspiration function of the present invention and the method for producing the UV-blocking agent using the same according to the present invention can effectively and uniformly mix the glycopyrrolate component, which is a component having antiperspirant action, with the UV- Compared with the use of the conventional ultraviolet screening material alone, the release of perspiration is effectively suppressed, so that the feeling of use and comfort are improved when sunscreen is used, the damage of the sunscreen coating film due to secretion of sweat is reduced, Which can reduce the amount of the organic / inorganic sunscreen agent to minimize disadvantages such as skin irritation, toxicity, stability, and release of environmental hormones, while enhancing the ultraviolet screening function.

Description

[0001] The present invention relates to a UV-blocking cosmetic composition having antiperspirant function, and a UV blocking cosmetic composition having an antiperspirant function and a UV blocking agent using the same,

The present invention relates to a functional UV-blocking cosmetic composition having an anti-perspiration function and a process for preparing an ultraviolet screening agent using the same. More specifically, the present invention relates to a functional UV- And a method for producing an ultraviolet screening agent using the functional ultraviolet screening cosmetic composition.

As is well known, sunlight reaching the earth is largely divided into visible light, infrared light and ultraviolet light depending on the wavelength. Ultraviolet rays are collectively referred to as electromagnetic waves having a wavelength ranging from about 400 nm to about 10 nm. A region having a wavelength of 400 to 300 nm or more is referred to as a near-ultraviolet ray, and a region having a wavelength of 300 to 200 nm or less is referred to as a far ultraviolet ray.

Usually, ultraviolet rays reaching the surface of the earth hit the near-ultraviolet region, which absorbs almost ultraviolet rays of 290 nm or less in the atmosphere, so that only the near-ultraviolet region reaches the surface. These ultraviolet regions are divided into three regions A, B and C according to the wavelength. UV-C (less than 280 nm) is mostly blocked in the ozone layer, but UVA and UVB regions are not blocked, It has a direct effect.

Among them, UVA accounts for more than 90% of ultraviolet rays and is considered to be the main cause of skin aging, and it is a major cause of skin erythema, edema, freckles and skin cancer. UVB is not able to penetrate deep into the skin because of its short wavelength, but if it is exposed to excessive amount of sunlight, it causes skin aging. Accordingly, many ultraviolet screening products have recently been used to block the harmful effects of ultraviolet rays on the human body, and it is essential to use ultraviolet screening products to protect human body, especially skin.

The ultraviolet screening materials used up to now are largely classified into organic materials and inorganic materials. Organic materials are mostly composed of synthetic materials, and cinnamate derivatives are the main natural materials. However, these organic materials have poor light stability and have many disadvantages such as phototoxicity, skin irritation, and environmental hormone excretion.

In addition, there are inorganic materials such as TiO ₂ and ZnO, which are currently used as ultraviolet shielding materials, and they are used in an excessive amount due to the blocking efficiency and are not free from the controversy about the harmfulness of nanomaterials which is a problem of cloudiness, phototoxicity, stabilization and safety. At present, research trends of UV blocking agents are required to improve the usability of inorganic sunscreen agents by making them microparticulate and to develop techniques to inhibit white turbidity phenomenon.

Therefore, in the field of UV protection, it is required to develop new technologies as well as to improve product quality and develop new functional sunscreen materials.

[(2-Cyclopentyl-2-hydroxy-2-phenylacetyl) oxy] -1,1-dimethylpyrrolidinium bromide used in the present invention; 1] is a safe substance registered in the 36th edition of the United States Pharmacopoeia (USP), which has the structure of a quaternary methylbromide ammonium salt structure as shown in the structural formula shown in FIG. 1, and is commercially available as an enantiomer.

The above-mentioned glycopyrrolate is an anticholinergic agent and blocks the interaction of acetylcholine, which is a transmitter of parasympathetic nerve, with muscarinic cholinergic receptors, thereby reducing the occurrence of sweat. In other words, it is not a mechanism of physically blocking sweat glands (physicochemical), but a mechanism of inactivation. This is because glycopyrrolate is a quaternary ammonium salt, it is a very effective drug for treating local hyperhidrosis because it does not penetrate the skin when it is applied to the skin and is not absorbed into the blood, so it acts only locally and does not circulate blood systemically .

The above-mentioned glycopyrrolate can also be used for skin and facial sweating. An agent or an injection for administration in a glycopyrrolate administered with a light or an injectable preparation is a pre-operative basic drug used for suppressing the occurrence of excessive mucus during surgery to be.

Analyzing the contents described in the patent documents published up to now shows that the effect of inhibiting sweat secretion at the time of prescribing glycopyrrolate is increased, the effect of decreasing perspiration odor is decreased and the viscosity is decreased, And the manufacturing method which is considered to be excellent in various product properties are listed. In order to soften the touch, it can be added as a cosmetic flavor together with a bactericidal product, inhibition of skin microbial growth, The main point is that it is.

For example, International Patent Publication No. W02003011340A1 (Feb. 13, 2003) entitled " Medicament Formulation for Topical Application of the Therapy and Prophylaxis of Hyperhydrosis ", which contains 4% of glycopyrrolate and 2.5% of hydroxyethylcellulose, , 10% of glycerin is disclosed as a therapeutic and preventive agent for hyperhidrosis, US Patent No. 8,252,316 B (Aug. 28, 2012) entitled " Method of topically applied glycopyrrolate solution using absorbent pad to reduce sweating & A water-soluble preparation containing ethanol is disclosed in which a non-sticky simple alcohol formulation containing no incremental agent and using glycopyrrolate in a pad is used, and International Patent Publication No. WO 2006069998A2 (2006.7.6) discloses a glycopyrrolate in quot; cosmetic preparations ", glycosyl pyrrolate is incorporated in cosmetics to produce cosmetic preparations having anti-perspiration properties 139 kinds of cosmetics prescription and manufacturing methods are enumerated including tube type, roll type, bottle packing type, etc., all of which are used to prepare various gelatin, ointment and cream preparations. The prescription or manufacturing method for functional sunscreen is not described or claimed.

Korean Patent Laid-Open Publication No. 2015-0128942 discloses a method for treating hyperhidrosis of a mammal such as a human suffering from hyperhidrosis using a soft anticholinergic agent, and as a pharmaceutical composition containing the same, the use of glycopyrrolate is disclosed Only.

However, as described above, the conventional ultraviolet screening agents still have a lot of problems to be improved. To solve the problems, it is required to develop new technologies and improve the quality of products and develop new functional ultraviolet screening agent materials. Is presented. As a problem to be solved by the conventional ultraviolet screening agent, for example, the inconvenience of using the ultraviolet screening agent due to the emission of hot summer perspiration is still not completely solved, For example, Korean Patent Laid-Open Publication No. 2014-0101593 discloses a method for preparing a porous powder component of silica or a silica component, which is a porous powder component, as a sebum control agent. Discloses a sunscreen composition capable of raising the ultraviolet shielding effect by absorbing sweat and sebum either alone or in combination. In Korean Patent Laid-Open Publication No. 2016-0111212, an underwater sunscreen cosmetic composition contains an algin The structure of this formulation is robust The ultraviolet ray blocking effect is remarkably excellent, and in particular, this ultraviolet ray cosmetic composition for underwater type ultraviolet ray shielding composition is said to have excellent persistence of ultraviolet ray blocking effect when it is encountered an aqueous solution containing minerals such as sweat and sea water, There is no suggestion for a functional sunscreen agent.

Accordingly, the inventors of the present invention have made a study to develop a functional sunscreen agent having an antiperspirant function in recognition of the problems in the above-described conventional techniques, and as a result, it has been found that the skin- The sunscreen which is prevented from being damaged due to the secretion of sweat or from the breakage of the skin on the skin due to the flow of the sweat and the sunscreen which is buried in the course of wiping off the secreted sweat The inventors of the present invention have made intensive studies to develop an innovative novel functional sunscreen agent that can prevent damage to the coating film and consequently improve the ultraviolet shielding ability, prolong the duration, and suppress the secretion of sweat, .

Patent Document 1: International Patent Publication No. WO 2003011340A1 Patent Document 2: United States Patent Application Publication No. US 8,252,316 B Patent Document 3: International Patent Publication No. WO 2006069998A2 Patent Document 4: Korean Patent Laid-Open Publication No. 2015-0128942 Patent Document 5: Korean Patent Laid-Open Publication No. 2014-0101593 Patent Document 6: Korean Patent Laid-Open Publication No. 2016-0111212

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and it is a primary object of the present invention to provide an ultraviolet screening agent which is free from the problems of the prior art, namely sticky or blurred, , Lifting phenomenon, etc. are improved to improve the feeling of comfort during use, the thin coating film of the sun cream applied to the skin due to the secreted sweat is damaged, or when the sweat is wiped, the sunscreen coating film is peeled off and the sun protection effect is often decreased. It is intended to provide a new innovative functional ultraviolet (UV) blocking cosmetic composition having an antiperspirant function and at the same time having an ultraviolet shielding function in order to improve disadvantages of use and to enhance the comfort of the user.

Another object of the present invention is to provide a method for manufacturing an ultraviolet screening agent more easily using the ultraviolet barrier cosmetic composition having the above excellent functionality.

The present invention may also be directed to accomplish these and other objects, which can be easily derived by those skilled in the art from the overall description of the present specification, in addition to the above-mentioned and obvious objects.

In order to accomplish the above object, the present invention provides an ultraviolet barrier cosmetic composition having an anti-perspiration function;

(2-Cyclopentyl-2-hydroxy-2-phenylacetyl) oxy] -1,1-dimethyl pyrrolidinium bromide] having an antiperspirant action and at least one component selected from organic UV blocking agents and inorganic UV blocking agents as active ingredients .

According to another embodiment of the present invention, the organic ultraviolet screening agent is at least one selected from the group consisting of octyl methoxycinnamate, homosalate, disodium phenyldipisimidazole tetrasulfonate, di-methoxycinnamate, benzophenone- , Benzophenone-8 (dioxybenzone), butylmethoxydibenzoylmethane (avobenzone), bishexylhexyloxyphenol methoxyphenyltriazine, octocrylene, ethylhexylmethylmethylphenyl, ethylhexylmethoxycinnamate, Octyl methoxycinnamate, octyl methoxycinnamate, ethyl hexyl triazone, isoamyl p-methoxy cinnamate, and thiai-salicylate.

According to another embodiment of the present invention, the inorganic ultraviolet screening agent is composed of at least one component selected from the group consisting of zinc oxide and titanium dioxide.

According to another embodiment of the present invention, the content of the glycopyrrolate is 0.01 to 1.0% by weight based on the total weight of the cosmetic composition, and the content of only one of the organic ultraviolet screening agent and the inorganic ultraviolet screening agent, 0.01 to 35% by weight, and the content of the organic and inorganic ultraviolet screening agents is 0.01 to 35% by weight when the organic ultraviolet screening agent and the inorganic ultraviolet screening agent are contained simultaneously.

According to another embodiment of the present invention, the ultraviolet barrier cosmetic composition comprises potassium cetyl phosphate.

According to another embodiment of the present invention, the ultraviolet barrier cosmetic composition is characterized by containing potassium cetyl phosphate in an amount of 0.5 to 4.0% by weight based on the total weight (%) of the cosmetic composition. Since potassium cetyl phosphate is contained in such a manner, the glycopyrrolate can be homogeneously mixed with the organic or inorganic ultraviolet screening agent component, thereby solving problems in production with a sunscreen cosmetic composition, for example, difficulty in formulating, I could.

According to another aspect of the present invention, there is provided a method of manufacturing an ultraviolet screening agent using the UV-blocking cosmetic composition having anti-perspiration function.

Adding purified water to the vessel, dissolving disodium EDTA, carbomer, xanthan gum and potassium cetyl phosphate in this order to prepare a solution A by heating to 65 to 75 ° C;

In another container, a mixture of stearic acid solution, glyceryl stearate, octylmethoxycinnamate, octocrylene, octyl salicylate, butylmethoxydibenzoylmethane, phenoxyethanol, dimethicone, glycopyrrolate and glycerin Followed by dissolving while maintaining the temperature at 60 to 80 캜 to prepare solution B; And

The solution B was slowly added to the previously prepared solution A while vigorously stirring. Then, the solution B was stirred at the same temperature for 1 hour, cooled gradually to 40 to 60 ° C, and then bis-ethylhexyloxyphenol methoxy Phenylpyrazine, isopropyl myristate, butylene glycol and soapolanol are added to the mixture, cooled to room temperature, added with a lavender flavor, and stirred for 1 hour to several hours to prepare an ultraviolet screening agent having antiperspirant function . As described above, the solution A and the solution B are separately prepared and mixed according to the constitution of the present invention, so that the water-soluble component and the oil-soluble component are mixed well to obtain a homogeneous ultraviolet screening agent.

According to another aspect of the present invention, the ultraviolet screening agent is characterized in that the ultraviolet screening agent is made of any one selected from the group consisting of lotion, cream, essence, foundation and powder.

The UV-blocking cosmetic composition having the anti-perspiration function of the present invention and the method for producing the UV-blocking agent using the same according to the present invention can effectively and uniformly mix the glycopyrrolate component, which is a component having antiperspirant action, with the UV- Compared with the use of the conventional ultraviolet screening material alone, the release of perspiration is effectively suppressed, so that the feeling of use and comfort are improved when sunscreen is used, the damage of the sunscreen coating film due to secretion of sweat is reduced, Which can reduce the amount of the organic / inorganic sunscreen agent to minimize disadvantages such as skin irritation, toxicity, stability, and release of environmental hormones, while enhancing the ultraviolet screening function. As described above, the present invention provides a new innovative functional sunscreen cosmetic composition containing glycopyrrolate and an organic and / or inorganic ultraviolet screening agent as an active ingredient and having an antiperspirant action and simultaneously exhibiting ultraviolet shielding action.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing the effect of an enantiomer of glycopyrrolate [(2-Cyclopentyl-2-hydroxy-2-phenylacetyl) oxy] -1,1-dimethyl pyrrolidinium bromide] Fig.

Hereinafter, the present invention will be described in more detail with reference to preferred embodiments with reference to the accompanying drawings, but it goes without saying that the present invention is not limited to the following embodiments and various modifications can be made within the scope of the gist of the present invention . Furthermore, well-known components, well known operations, and well-known techniques are not specifically described in the detailed description to avoid obscuring the present invention.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In the present specification, the singular forms include plural forms unless otherwise specified in the specification. Also, components and acts referred to as " comprising (or comprising) " do not exclude the presence or addition of one or more other components and operations.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

The term " sun cream ", as used herein, refers collectively to products that function to protect the skin from the sun's ultraviolet (UV) And is generally referred to as a sun block in the cosmetics group.

The present invention provides a new innovative cosmetic composition for protecting against UV rays containing glycopyrrolate and an organic and inorganic ultraviolet screening agent as an active ingredient. In the present invention, glycopyrrolate having an anti- In combination with the components having action to prevent the skin-damaging film of sunscreen from being damaged through the perspiration-suppressing action and to compensate for the disadvantages of the existing organic and inorganic sunscreen agents used alone, , A new innovative functional sunscreen that provides less feeling of sweat and less feeling of use.

According to a preferred embodiment of the present invention, the main component of the organic UV screening agent used together with the glycopyrrolate is octyl methoxycinnamate, homosalate, drometrizol trisiloxane, disodium phenyldipisimidazole tetrasulfo Methoxy cinnamate, benzophenone-3 (oxybenzone), benzophenone-8 (dioxybenzone), butylmethoxydibenzoylmethane, bishexyloxyphenol methoxyphenyltriazine, octocrylene , It is preferable to use hexyl cyde methylphenyl, ethyl hexyl methoxycinnamate, hexyl hexyl triisocyanate, isoamyl p-methoxy cinnamate and thiai-salicylate, They can be used in combination.

Another aspect of the present invention is to provide a cosmetic composition for UV screening which contains glycopyrrolate and an inorganic UV-blocking agent as an active ingredient. In a preferred embodiment of the present invention, zinc oxide and / or titanium dioxide is preferably used as a major component of the inorganic ultraviolet screening agent used together with the glycopyrrolate. In the present invention, zinc oxide, which is used as an example of an inorganic barrier agent, is a substance that does not cause skin allergy as well as an ultraviolet ray blocking effect, and is proved to be safe as a skin protecting agent. In addition, usually, the inorganic blockade agent has less harmfulness to human body than the organic blockade agent.

In a specific embodiment of the present invention, the content of the glycopyrrolate may be 0.01 to 1.0% by weight based on the total weight of the cosmetic composition, and the content of the organic or inorganic ultraviolet screening agent may be 0.01 to 45% And preferably 0.01 to 35% by weight. When the content of the glycopyrrolate is less than 0.01% by weight based on the total weight (%) of the cosmetic composition, there is a problem that the perspiration inhibiting ability is remarkably lowered and the problem to be achieved by the present invention can hardly be achieved. On the other hand, Even if it exceeds 1.0% by weight based on the total weight (%) of the cosmetic composition, a better effect on the anti-perspiration function can not be expected, but rather it is difficult to formulate and the spreadability of sunscreen is remarkably reduced. The content of the glycopyrrolate is most preferably 0.05% by weight based on the total weight (%) of the cosmetic composition.

In the present invention, sunscreen is prepared by mixing glycopyrrolate with an organic ultraviolet screening agent or an inorganic ultraviolet screening agent, or by using a combination of glycopyrrolate and an organic and inorganic ultraviolet screening agent at the same time.

A method for manufacturing an ultraviolet screening agent using the ultraviolet barrier cosmetic composition having an anti-perspiration function according to a preferred embodiment of the present invention will be briefly described below.

First, add purified water to the container and add disodium EDTA, which is a metal ion sequestering agent (to prevent metal ion oxidation catalyst), carbomer as thickener, xanthan gum used as thickener for skin-friendly formulation, dispersion and emulsification of incompatible components Potassium cetyl phosphate, which is a raw material to aid the reaction, is completely dissolved, and then the solution A is prepared by heating to 60 to 80 ° C.

Next, in another container, a mixture of a stearic acid, a kind of fatty acid acting as an emulsifier, glyceryl stearate, a surfactant, octyl methoxycinnamate, octocrylene, octyl salicylate, butyl methoxydibenzoylmethane , Dimethicone, which acts as a sterilizing preservative, dimethicone, which prevents foaming and delays water evaporation from the skin surface, glycopyrrolate, which has antiperspirant properties, has side effects and has a skin-softening action Glycerin was added thereto, and the mixture was stirred and maintained at 60 to 80 ° C. The resulting solution was gradually added to the solution A prepared in the previous step while stirring the mixture. The mixture was stirred at the same temperature for 1 hour, After lowering the temperature to 60 ° C, the ultraviolet light blocking agent, bis-ethylhexyloxy Phenol methoxyphenyltriazine, isopropyl myristate used as a binder and skin softener, butylene glycol acting as a viscosity reducing agent and skin conditioner, an emulsifier and soapenol acting as a wetting agent, cooling to room temperature, Lavender fragrance is added thereto, and the mixture is stirred for several hours to prepare an ultraviolet screening agent having an antiperspirant function.

The ultraviolet screening agent thus prepared may be prepared in any one form selected from the group consisting of lotion, cream, essence and foundation, and the ultraviolet screening agent may be packaged in a packaging container suitable for packaging the tablet for each of these formulations.

The ultraviolet screening agent thus prepared is formulated by uniformly mixing glycopyrrolate having antiperspirant function with an ultraviolet screening component, so that the secretion of perspiration is suppressed as compared with the case of using the ultraviolet screening component alone, And the feeling of comfort is improved and the damage of the sunscreen coating film due to the secretion of sweat is reduced, thereby increasing the UV blocking efficiency. In addition, since the effect of the ultraviolet screening agent is improved as described above, the use amount of the organic / inorganic ultraviolet screening agent can be reduced, thereby providing an action effect of minimizing disadvantages such as skin irritation, toxicity, stability, .

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but it goes without saying that the present invention is not limited to these Examples.

Example 1: Production of a UV-blocking cosmetic composition containing glycopyrrolate (sunscreen formulation containing 0.1% of clinopyrolate).

The preparation of a UV-blocking cosmetic composition containing glycopyrrolate according to the present invention was prepared as follows, based on the components and the contents of the following Table 1;

1. Ranking of raw materials 1) To purified water, 1) disodium EDTA, 1-2) carbomer, 1-3) xanthan gum, and 1-4) potassium cetyl phosphate were added in order and completely dissolved at about 70 ° C, . The purified water was 39.10 wt%.

2. Raw materials in other containers 2) Stearic liquid seeds, 2-1) Glyceryl stearate SE, 2-2) Octylmethoxycinnamate, 2-3) Octocrylene, 2-4) Octyl salicylate, 2-5) butylmethoxydibenzoylmethane, 2-6) phenoxyethanol, 2-7) dimethicone, 2-8) glycopyrrolate (RS, SR form), 2-9) glycerin The solution B is dissolved by maintaining the temperature at about 70 캜. At this time, 2-8) glycopyrrolate was added at 0.1 wt%.

3. While stirring the solution A vigorously, the solution B is slowly added at a temperature of about 70 ° C and then cooled to 50 ° C.

4. Keeping the temperature at 50 ° C, the raw material is classified as 3.) bis-ethylhexyloxyphenol methoxyphenyltriazine, 3-1) isobutylene glycol, 3-2) butylene glycol, 3-3) Are added sequentially and dissolved while stirring.

5. Cool to room temperature, add 3-4) Lavender flavor, stir for about 3 hours and fill it into a laminate tube.

Example 2 A formulation of the composition of Example 1 and a sunscreen preparation to which 0.01% of clinopyrolate was added

The sunscreen is prepared in the same manner as in Example 1 except that the purified water content is 40.19% by weight and the glycopyrrolate content is 0.01% by weight.

Example 3 A sunscreen preparation containing 5.0% by weight of octocrylene and 0.05% by weight of glycopyrrolate and 3.0% by weight of titanium dioxide in the composition formulation and the preparation method of Example 1.

Adding 40 wt% of purified water, 2-3 wt% of octocrylene, 5.0 wt% of 2-8) glycopyrrolate, 0.05 wt% of 3-3) soffanol, 3.0 wt% of titanium dioxide And the lavender fragrance was added thereto.

COMPARATIVE EXAMPLE 1: Preparation of ultraviolet-shielding cosmetic composition (formulation without clicophyllolate).

An ultraviolet barrier cosmetic composition containing purified water in an amount of 39.2% by weight and containing no glycopyrrolate was prepared in the same manner as in Example 1 with the components shown in the following Table 1 and its content.

Raw material ranking  Ingredients Ingredients   Blending ratio (% by weight)    Remarks One  Purified water      D * 1-1  Disodium EDTA       0.2 1-2  Carbomer       1.0 1-3  Xanthan gum       0.25 1-4  Potassium cetyl phosphate       2.00 2  Stearic acid       1.80 2-1  Glyceryl stearate SE       5.00 2-2  Octylmethoxy cinnamate       7.50 2-3  Octocrylene       8.00 2-4  Octyl salicylate       5.00 2-5  Butyl methoxydibenzoylmethane       3.00 2-6  Phenoxyethanol       0.80 2-7  Dimethicone       1.00 2-8  Glycopyrrolate (RS, SR form)       D *  USP 36 standard 2-9  glycerin       3.00 3 Bis-ethylhexyloxyphenol
Methoxyphenyltriazine     10.00 3-1  Isopropyl myristate      7.00 3-2  Butylene glycol      4.00 3-3  Softonol      0.2 3-4  Lavender incense      0.05

D *: Participation amount varies according to each embodiment.

Experimental Example

The persistence test for the anti-perspiration effect of the sunscreen preparation is an overestimation test, which is performed in a controlled warm room at a temperature of 40 ° C according to the regulations of the United States Federal Standard for the Development of Hyperhidrosis, The left side of the armpit and the left side of the arm were subjected to a blank test to measure the amount of foot, and then a medication was applied to the armpits and forearms. After a certain period of time, a difference of 20% or more was observed between the armpit and the forearms If it occurs, the system which is judged to be effective as a therapeutic agent for hyperhidrosis is applied in accordance with the test.

In particular, in sweating test of the forearm area, it is a significant test method to visually confirm the degree of sweating. Glycopyrrolate-containing preparations are substances which are already effective in hyperhidrosis after passing the test. Use the above test to compare the effect of over 24 hours (first-order) and after 48 hours (second-order excess) by performing additional US federal standard sweating test for excess effect.

US Federal Hyperhidrosis Test Regulation Note: Antiperspirant Drug Products for OTC Human Use-US FDA- 16. May 2003, Federal Register / Vol.68, No.110, Jun.9. 2003. According to the above regulation, although the clinical test effect on the existing product is sustained for 24 hours, the over 48 hour effect is not statistically significant. Therefore, in the present invention, the pharmaceutical improvement A brief preliminary test was conducted for the applicants of the test for the present invention (man N = 2 adult male).

<Skin irritation test for product>.

A mutual skin irritation test was conducted on the product (glycopyrrolate content 0%) and the product of Example 1 (glycopyrrolate content 0.1%) (N = 2 adult male).

The inside of the forearm (Forearm, Forearm) was coated with 4cm X 10cm everyday from Monday to Friday, and the area was considered when there was no change even when it was performed on the forehead. As a result of the test, slight flare was slightly observed, but the pathological condition did not appear in both parts.

Skin Hyperhidrosis and Facial Hyperhidrosis Inhibitory Effect and Persistence Test.

COMPARATIVE EXAMPLE 1 Products and Examples 1 to 3 US Federal Standard for Hyperhidrosis Therapeutic Agent For the overestimation test, the armpit of a volunteer (N = 2 adult male) with a level of hyperhidrosis as defined by the US Federal Standard in a 40 ° C As shown in the following Table 2 (armpit) and 3 (forward arm), the anti-perspiration application tests of sunscreen on the left and right arms and the forearm arms (Forearm and forearm) Compared with the product of Example 1, the anti-perspiration effect of 1.5 hours and the effect of sustaining the 24 hours were found to have an anti-perspiration effect as compared with the product of Comparative Example 1. Also, the product of Example 3 suppressed sweating at 1.5 hours and 24 hours It was found that the effect was weaker than that of Comparative Example 1.

The sweating inhibition test according to the site of the above Experimental Example was specifically carried out as follows;

1. Attach the padded pads, which measure weight, to the sides of both arms and to the inside of both forearms.

2. Enter the warm room (40 ℃) and swim for 10 minutes.

3. Remove the attached pad and measure the weight of each pad.

4. The subject takes a 10-minute break while taking water (approximately 500 ml).

5. Apply the sunscreen of the comparative example and the example to an area of 4 cm x 4 cm on the left armpit and an area of 7 cm x 7 cm on the inside of the right forearm.

6. Apply the sunscreen of the comparative example and the example to an area of 4 cm x 4 cm on the right armpit and an area of 7 cm x 7 cm on the inside of the left forearm.

7. 1.5 hours Wait for the sunscreen of the Comparative Example and the Example to be absorbed.

8. Wash areas where the sunscreen applied in the comparative examples and the examples are applied and completely remove the water.

9. Attach the blank pads, which weigh, to each of the areas to which they applied the sunscreen in each of the Comparative Examples and Examples.

10. Enter into a warm room (40 ℃) and persecute for 10 minutes.

11. Remove the attached pad and measure the weight of each pad.

12. Repeat steps 9 to 11 after 24 hours and 48 hours after sunscreen application.

Subject 1 1.5 hours 24 hours 48 hours Subject 2 1.5 hours 24 hours 48 hours Comparative Example 1 100% 100% 100% Comparative Example 1 100% 100% 100% Example 1 80.0% 89.9% 100% Example 1 79.8% 90.5% 100% Example 2 90.0% 95.0% 100% Example 2 88.9% 94.2% 100% Example 3 85.9% 94.8% 100% Example 3 84.2% 95.1% 100%

Subject 1 1.5 hours 24 hours 48 hours Subject 2 1.5 hours 24 hours 48 hours Comparative Example 1 100% 100% 100% Comparative Example 1 100% 100% 100% Example 1 79.5% 88.9% 100% Example 1 80.7% 91.2% 100% Example 2 92.1% 96.3% 100% Example 2 90.2% 95.1% 100% Example 3 86.9% 94.3% 100% Example 3 72.7% 87% 100%

The antiperspirant effect (Z (%)) was calculated by the following equation

[Z (%) = (PC X T) / (PT X C) X 100]

PC: the amount of treatment before the treatment site

PT: the amount of test before treatment

T: Shoot after 1.5, 24, 48 hours after sunscreen application

C: After 1.5, 24 and 48 hours after application of sunscreen

As a result of skin irritation test, skin and axillary sweating inhibition effect and persistence test on the sunscreen product of the present invention, it was confirmed that the formulation containing 0.01% of Example 1, which is a 0.1% -containing formulation of the present invention containing three glycopyrrolate weight% Example 2 and Example 3, which is a 0.05% -containing preparation, showed that the sunscreen of Example 2 had weaker anti-perspiration and sustenance effects than Example 1, and Example 3 showed weaker anti- Respectively.

Although the preferred embodiments of the ultraviolet barrier cosmetic composition having antiperspirant function and the method for manufacturing the ultraviolet barrier agent using the ultraviolet barrier cosmetic composition have been described in detail in the foregoing description of the present invention, It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the appended claims.

(Without reference numerals)

Claims (7)

0.01 to 0.1% by weight of glycopyrrolate [(2-Cyclopentyl-2-hydroxy-2-phenylacetyl) oxy] -1,1-dimethylpyrrolidinium bromide having an anti-perspiration activity relative to the total weight (%) of the cosmetic composition. Organic sunscreen agents; And 2.0 wt% potassium cetyl phosphate; &Lt; / RTI &gt;
delete The ultraviolet-blocking cosmetic composition according to claim 1, wherein the content of the organic ultraviolet screening agent is 0.01 to 35% by weight.
The composition of claim 1, wherein the organic UV blocking agent is at least one selected from the group consisting of octyl methoxycinnamate, homosalate, disodium phenyldipisimidazole tetrasulfonate, diestermethoxycinnamate, benzophenone-3 (oxybenzone) Hexyloxyphenol methoxyphenyltriazine, octocrylene, ethylhexylmethylmethylphenyl, ethylhexylmethoxycinnamate, octylmethoxyphenylacetate, octylmethoxycinnamate, octylmethoxycinnamate, octylmethoxycinnamate, Wherein the cosmetic composition is composed of at least one component selected from the group consisting of ethoxyl cinnamate, ethyl hexyl triazone, isoamyl p-methoxy cinnamate, and thiai-salicylate.
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