KR101942597B1 - System and method for personalized injection treatment - Google Patents

Abstract

A system 100 for dispensing a medicament for an injection therapy for a patient comprises: a housing 110 surrounding the interior space; An inventory structure (130) comprising a plurality of chambers (131) that individually support one or more disposable capsules (102) containing medicines, each capsule having an inventory volume of about 0.1 to 10.0 mL of liquid volume 130); A capsule selection means (140) for selecting a capsule according to a predetermined medicine contained in the capsule; Means (150) for moving the selected capsule into the treatment region; Drug delivery means (165, 166) for delivering a controlled quantity of the predetermined medicament sequentially, in direct fluid communication from each selected capsule to the product container under the action of positive or negative pressure; And means 151 for automatically discarding the used capsule from which the drug is removed after a single use.

Description

SYSTEM AND METHOD FOR PERSONALIZED INJECTION TREATMENT [0002]

The present application claims priority to U.S. Provisional Application No. 61 / 437,152, filed January 28, 2011, the entire contents of which are incorporated herein by reference.

The present invention is directed to a system and method for performing individualized injection therapy for administering a drug to a patient.

Americans are increasingly aware of the health environment, available drugs, and information technology. Americans demand that disease prevention and treatment should be done according to individualized needs, if possible.

There is a great advantage in injecting a mixture of drug substances such as vitamins, growth hormones, glucosamine, omega-3 fatty acids, insulin and other medicinal materials. In the case of taking the drug, the bioavailability of this drug (i.e., the fraction of digested drug dose actually absorbed) is significantly elevated because of variable incomplete absorption and first-pass metabolism first-pass metabolism. However, the bioavailability of the medicament injected into the vein can be up to 100%. It is also known that a population of 15% can not adequately absorb vitamins and other medications when administered with medications. However, since the drug treatment conditions may be different from each other, it is necessary to formulate and develop the drug substance individually in the injection to meet the needs of the patient.

Researchers in the UK say that patients are injected with vitamin E extracts and tumors begin to be forgiven within 24 hours. After 10 days, the tumor almost disappeared. According to Dr. Jane Higdon of Oregon State University, there is no recent evidence that alpha-tocopheryl succinate is delivered to tissues by taking alpha-tocopheryl succinate in humans. Studies have suggested that the bioavailability of natural vitamin E is two times that of synthetic. In addition, studies on patients with poor absorption of fat are important in that they show that vitamin E uptake requires a general digestion process related to absorption of edible fats. Taking vitamin E for the proper absorption of edible fats is complicating the problem because the amount or form of fat required for proper vitamin E absorption is not known.

Similarly, gastrointestinal absorption of vitamin B12 is dependent on sufficient intrinsic factors and the presence of calcium ions. In patients with fatal anemia or other conditions, oral absorption is considered to be highly unreliable, and intake of vitamin B12 prevents the process of nerve damage in many cases. Parenteral administration of vitamin B12 addresses a variety of conditions, including lethal anemia, age-related vitamin B12 deficiencies, alleviates a severe level of Alzheimer's disease, and is associated with the treatment of senile dementia, autism / ADD treatment, and therapeutic value in multiple sclerosis Reverses / holds cases. According to reports, 94% of children with autism spectrum disorder syndrome responded to methyl-B12 treatment (vitamin B12 injection).

Various systems for mixing various drugs in a single container are known. For example, for various fluid delivery and mixing systems, U.S. Patent Nos. 7,610,116, 7,194,336, 7,171,992, 6,975,924, 6,951,228, 5,697,407, 5,431,202, 5,085,256, 5,040,699, 4,922,975, 4,789,014, 4,653,010, 4,513,796, 4,467,844 can be referred to.

However, there is a significant pharmacoeconomic difference between prescription drug treatment with medications and general self-care with recently available medications. A system that can be used in hospitals or clinics is needed to enable individualized patient care as drugs, biologically medicated additives, intravenous, intramuscular, or subcutaneous injectable additives. In addition, there is a need for a system encompassing the latest information technology employing, for example, wireless, software and / or Internet based communication systems.

An automated system is provided for preparing a medication for an injection therapy to a patient. The system includes: a housing surrounding an interior space; An inventory structure having a plurality of chambers individually containing one or more medicaments with disposable capsules, each capsule comprising: an inventory structure having a liquid volume of about 0.1 to 10.0 mL; Capsule selection means for selecting a capsule according to a predetermined medicine contained in the capsule; A capsule moving means for moving the capsule selected as the treatment region; Means for continuously delivering a controlled quantity of the predetermined medicament by directing fluid from each selected capsule to a product container such as a syringe or product vial under a positive or negative pressure; And means for automatically discarding the capsules used after the single use of the medicament.

Innovative technology enables a new, personalized medical platform that enables personalized medical opportunities to be implemented, and this platform can be used to safely and effectively expand healthcare services, improve quality of care, and improve outcomes. Such devices are applicable to patients in need of effective doses of vitamins, growth hormone, omega-3, onabotulinum toxin A, insulin, and other drug combinations used in injections in hospitals

Various embodiments are described with reference to the drawings.
1 is a perspective view showing an embodiment of the present invention.
Figures 2A-2D are diagrams illustrating the preparation of a product vial by mounting a connector and a cap attached thereto.
3A and 3B are a front perspective view and a rear perspective view of the interior of the apparatus of the present invention.
4 is a perspective view of the channel member.
Figure 5 shows a capsule containing a drug.
6 and 7 are views showing the movement of the sliding gate 141 at the bottom of the channel member to release the capsule from the bottom of the channel member, respectively.
Figures 8 and 9 are internal perspective views showing conveyor means for moving the capsule to a treatment area.
10A and 10B illustrate a capsule including a movable platform for raising a product vial with a connector attached in an upper position (Fig. 10A) to a lower position (Fig. 10A) to pierce the capsule containing the drug And FIG.
11 is a diagram showing caliper means for applying a positive external pressure to pressurize the capsule and force the medicament into the treatment vial.
12 is a plan view of the caliper and the capsule.
Figures 13A and 13B are perspective and enlarged views showing disposing of a capsule used as a discard bin.
14A and 14B are perspective views of another embodiment of the present invention.
Figure 15 is an internal view of the embodiment of Figures 14A and 14B.
16 is a view showing a capsule containing a medicine.
17 is a perspective view of loading the capsule with the device of the present invention.
18 is a perspective view of the inventory structure.
19 is a view showing a hypodermic syringe.
20 is a view showing loading of the hypodermic syringe with the device of the present invention.
Figures 21 and 22 are diagrams illustrating the placement of a hypodermic syringe in a syringe station.
23 and 24 are views showing the arrangement of the rotary conveyor, the operating cylinder and the blocking plate.
25A to 25G are views showing removing the cap from the hypodermic syringe, puncturing the capsule, and loading the hypodermic syringe with the drug.
26 is a view showing a shielding plate having an open gate.
27 is a view showing a shielding plate having an open gate arranged to discard a capsule used as a used capsule treatment bin.
28 is a perspective view of another embodiment of the system device of the present invention.
29A and 29B are perspective views of the interior of the embodiment shown in Fig.
30 is a view showing loading a capsule with a rotating carousel.
31 is a perspective view of the working cylinder and the blocking plate with means for perforating and discarding the capsule.
32A and 32B are plan views showing punching of the capsule by the extraction needle.
33A and 33B are diagrams illustrating delivery of a drug to a product vial.
34A and 34B are diagrams showing disposal of the waste solvent.
35 is a view showing a selective structure of a capsule containing a drug.
36 is a view showing applying a positive pressure in the vertical direction to the capsule to discharge the medicine from the capsule;
37A and 37B are views showing the application of a positive lateral pressure to the capsule to discharge the medicine from the capsule.
Figures 38A-43D are diagrams illustrating the system arrangement of the present invention for monitoring the position of the capsule and the sensor arrangement in various components of the apparatus.
44 is a view showing loading of a linear channel member into an inventory structure of a rotary conveyor shape;

All numbers expressing quantities of materials, reaction conditions, time intervals, quantitative characteristics of materials, and the like, as described herein and in the claims, unless otherwise indicated in the operating examples or in the claims, As will be appreciated by those skilled in the art.

Any numerical range recited herein is understood to include all sub-ranges within that range.

Any compound, material or component described in the specification and described in the specification and directly or indirectly in the claims, whether belonging to a structurally grouped, constituent or functionally related component, includes individually representing the group or all combinations thereof.

The systems and methods of personalized injection therapy are synchronized to complementary healthcare systems (which can be computerized and networked with wired and wireless connections) and automatically prepare and record patient-specific dosages of injectable drugs for disease prevention and / or treatment , The patient's course will be monitored over the Internet. The term "patient " means a sick or healthy human or animal (e.g., dog, cat, pig, horse or cattle). The term "drug" is used to refer to an injectable solution that provides health benefits and / or therapeutic effects and / or therapeutic potential, including, but not limited to, vitamins, drugs, functional foods, biological drugs or combinations thereof . The present invention prepares the ingredients at customized and customized dosage rates and prepares one product container, such as a syringe or product vial for infusion. The size of the device of the present invention is similar to one cup coffee machine or ink jet / laser printer for flavor. The ratio is determined by a physician or a scientifically valid Internet tool. The doctor personalized prepare an injectable solution, such as vitamins, growth hormone, glucosamine, omega-3, shine beam over Turi toxin A (Botox e.g. ^ⓡ) and insulin through a communication device such as a computer, PDA, smartphone The order will come down. An operator, such as a doctor or nurse, enters the dispensing order directly or manually using the control pad, and the system has a control screen such as LED and LCD. Optionally, the system may have a touch screen unit that combines a display and an input unit. When a single product container is created, the optimizer simultaneously enters patient information into the server. The patient will receive a set of codes in advance via the internet protocol and fetch the output for the physician. The inventory structure has a plurality of vertical chambers that individually support capsules containing one or more medicaments. Each chamber may store 10 to 30 capsules. The capsules have a volume of about 0.1 to 10.0 mL, preferably 0.1 to 2.0 mL, most preferably about 1.0 mL of liquid. The capsule and chamber containing the drug are clearly labeled and color coded. Once the capsule containing the drug is loaded into the device, the device dispenses the correct ratio into one injection product container. The transfer element is completely sterilized and the empty product container is loaded by the operator. The product container has a volume of about 0.1 to 10.0 mL, typically about 2.0 mL of liquid. The capsule and the product container are completely or partially filled with the medicament. Depending on the dispensing order, the capsule is selectively loaded and transferred to the processing region. In the treatment zone, the selected capsule is connected to the product container, and a predetermined amount of the drug is delivered to the product container under positive (+) pressure or negative (-) pressure. The positive pressure is formed by mechanically pressing the exterior of the selected capsule and the negative pressure against the interior of the selected capsule may be employed by a vacuum pump or syringe to draw the drug out of the capsule. Optionally, the capsule is suitably pressurized and packaged so that the inner solution automatically exits to the outside without auxiliary pressurization. The amount delivered is controlled by adjusting the amount of pressure and time applied. The spent medicinal capsules are automatically discarded after a single use. The solution within the capsule can be delivered through a connector that is disposed in the system and preassembled with the product vial as a cap prior to being configured as a needle and air vent. Optionally, the solution is delivered through an extraction needle associated with the loading capsule and a delivery system connected to the product dispenser. The system is enclosed by a housing, and a ventilation system can be included in the apparatus. All embodiments described below include a sterilizing means such as a UV lamp to provide an internal aseptic environment. A number of sensors, such as proximity sensors, distance sensors and temperature sensors, are arranged to monitor whether the capsule is loaded if necessary, monitor whether the system is properly functioning to check that the gate / door is closed, and monitor the temperature inside the system. Sensors used in each of the embodiments described below are commercially available, for example, from Sharp of Japan, Automation Direct of the United States, Keynes Corporation America of Itasca, and c3 Controls of the United States. After all the process is completed, the product container is discharged by the operator. A label containing patient information and preparation order in the form of text, bar code, or QR code is printed and the label is affixed to the product container and the patient chart.

Referring to Figures 1 to 13B, an embodiment of a system device 100 of the present invention for drug formulation is shown.

Figure 1 illustrates a housing 110 having an upper surface with a lid 111 that allows access to load a capsule containing the medicament into the system device. The housing 110 includes a liquid crystal screen 112 on the front wall that provides information to the user about the state and operation of the system. The front wall includes a keypad 113 for inputting operation instructions and data input. Optionally, the system 100 and the embodiments described below include a touch screen that includes the functions of inputting instructions / information and displaying information. The side surface has a door 114 for the label printer, the printed label being issued from the slot 115 on the front wall of the housing. The vial loading door 119 allows access to the empty product vial chamber 116 to load empty vials and to remove the filled vials therefrom. The door 117 provides access to the used capsule removal bin to be removed from the system device. Electronic components and microprocessors are mounted on the rear portion 118 of the device 100 that is open to provide access thereto.

The present invention includes a system that responds to instructions remotely provided by a computer / PDA / smartphone and cable, Bluetooth or Internet Protocol / Transmission Control Protocol (IP / TCP). These instructions regarding the type or amount of medication are formulated for the patient with appropriate patient information.

2A-2D, a product vial 103, preferably having a liquid volume of about 2.0 mL, is prepared to be filled by attaching the connector cap 170. The connector cap includes a needle 171 and an air vent 172 and seals the top of the product vial 103. The medicament is prepared in the product vial 103 used for the injection therapy of the patient. The protective cap 175 is mounted to the connector cap 170 before it is loaded into the medicament to prevent accidental needle steps when handling the product vial 103. The connector cap 170 includes an access port 173 into which the hypodermic needle is inserted to load the drug component onto the hypodermic syringe for subsequent injection to the patient. The protective cap 175 has a similar access port 176. The access ports 173, 176 include an elastic material, such as rosy, which is penetrated by the hypodermic needle but seals the port after subtracting the hypodermic needle.

3A-3B, in one embodiment of the present invention, the frame 120 surrounds and supports the internal mechanism of the system device 100. As shown in FIG. The frame 120 may be formed of a material such as, for example, acrylonitrile butadiene styrene (ABS), polycarbonate (PC), polyamide (PA), polybutylene terephthalate (PBT), polyethylene terephthalate (PPO), polysulfone (PSU), polyetherketone (PEK), polyetheretherketone (PEEK), polyimide, polyphenylene sulfide (PPS) and polyoxymethylene plastics Iron-based alloys. The upper, middle and lower levels of the apparatus are formed at least in part by the upper platform 121, the intermediate platform 122 and the lower platform 123. The inventory structure 130 is supported on the upper platform 121 as well as the UV lamp 107 and the label printer 108 for the sterilization environment. A temperature sensor (not shown) is disposed within the system to monitor whether the system is overheated. The inventory structure includes a plurality of chambers, such as vertical racks 131, in a side-by-side arrangement. Each of the racks has a linear inner space adapted to slidely receive a corresponding channel member 132 (Figure 4). The channel member 132 is adapted to receive and store a plurality of capsules 102 (FIG. 5) containing the medicament. Each of the capsules 102 has a cylindrical body 102a and a spherical end 102b and is perforated by a needle but strong enough to withstand normal handling stresses without breakage, breakage, and propagation of the incision propagation and without leakage after perforation Polymeric material. The capsule 102, the rack 131 and / or the channel member 132 are color-coded or recognized by a bar code so that appropriate medicines are loaded into the rack 131. Each of the channel members 132 includes an elongate body having side rails 133 that are slidably coupled to corresponding linear notches on the interior side surface of the rack 131. The channel member 132 has a wing portion 134 extending laterally at the top of the body to be gripped by a user's finger. The capsule separation system 141, described below, is connected to the slots at the bottom of each channel member 132.

Referring to FIGS. 6 and 7, the system 100 includes selection means for selecting a capsule according to the medicament contained therein. The selection means 140 includes a capsule separation system 141 and a motor 142 for moving the capsule separation system 141. The capsule separation system includes an upper gate 141a and a lower gate 141b which are slidably moved along the guide rail 144. [ The separation system 141 further includes a blocking plate 145 mounted on the upper gate 141a and slidably moving in and out of the slot 136 in the channel member 132. [ The capsule separation system is configured such that the upper panel interrupting plate 145 is completely connected to the slot 136 of each channel member 132 so that any capsule 102 from the channel member 132 And a second position in which the blocking plate 145 moves out of the slot of the channel member 132. In this case, However, in the second position, the lower gate 141b is moved below the lower portion of the channel member 132 to prevent the capsule from being further lowered. The capsule separation system 141 is moved back and forth relative to the first position and the selected capsule 102 is allowed to exit the bottom of the channel member 132, And comes to the first position where it is prevented from moving. The space between the blocking plate 145 and the lower gate 141b accommodates only one capsule. Therefore, the forward and backward movement of the capsule separation system 141 restricts the capsule 102 from escaping from the bottom of the channel member 132 to one capsule at a time. The motor 142 moves the gate 141 in response to an instruction to select a drug contained in the capsule 102 loaded in the rack 131. [ The operation of the motor 142 is regulated such that only one capsule 102 is discharged at a time. The discharged capsules 102 fall into the chute 143 which directs the capsules 102 onto the linear transport system as described below. Each rack 131 includes its own motor and capsule separation system.

8 and 9, the system 100 includes a linear transport system 150 as a means for moving the capsule 102 into a processing region, the means being coupled to each rack 131, A capsule holder 152 fixedly mounted on each saddling plate 155 which is alternately mounted on the conveyor belt / chain 151, and a linear actuator (not shown) 156: Figures 3A and 3B). Each capsule 102 has a spherical end portion 102b of the capsule that is moved linearly into the process region where the capsule 102 is individually punctured to force the liquid contents of the capsule 102 into the product vial 103 And falls through each of the chutes 153 into each of the capsule holders 152 having the spherical cavities to be accommodated. The guide channel 154 (FIG. 8) maintains the capsule in the proper orientation and position while moving.

Referring to FIGS. 10A and 10B, the processing region includes means for perforating the capsule 102 and means for delivering a quantity of the drug from the capsule to the product vial 103.

More specifically, piercing the capsule 102 is accomplished by loading the product vial 103 into the product vial chamber 116 and onto the product vial loading platform 161 with the connector cap 170 attached. The loading platform 161 is moved laterally to align the product vial 103 with respect to the capsule 102. The motorized cranking member 162 is urged vertically upwards until the needle 171 punctures the end 102b of the capsule 102 to allow fluid communication therebetween The product vial 103 is lifted.

11 and 12, the means for delivering the medicament from the capsule 102 to the product vial 103 includes a caliper (not shown) having a jaw 166 (jaw) moving between an open position and a closed position 165). The jaw 166 includes a flexible pad 168 that contacts the capsule 169. The cable 169 is connected to the arm 166a and the cable 169 closes the jaw 166 when pulled by the motor 195 as shown by the arrow in the figure. At the closed position, an external pressure is applied to the side 102a of the capsule 102 that forces the fluid medicament through the bore of the needle 171 into the jawon product vial 103. The amount of solution delivered is determined by controlling the applied external pressure, which is controlled by the tension or distance of the cable 169. The vent 172 of the connector cap 170 allows air to escape from the product vial 103 when it is filled. After the treatment of the capsule containing one drug is completed, the other capsule containing the other drug is moved to the treatment area for the same process until all the selected drugs are prepared.

Referring to Figures 13A and 13B, the system includes means for automatically discarding the used capsules 102 containing the used capsule waste bin 180 disposed at the end of the processing region. The conveyor belt 151 advances the capsule used as the end of the conveyor system 150 and the belt rotates downward so that the used capsules fall into the bin 180. The bins 180 are later removed from the system 100 through the capsule discard door 117. Thus, each capsule 102 is discarded after one use.

14A-27, another embodiment 200 of the present invention is shown. In this embodiment, the product container is a hypodermic syringe optimized for immediate use for injection.

14A and 14B, the housing 210 has a housing part 210a and a housing part 210b as two parts. The housing portion 210a includes a lead 211 on the top surface for encapsulation, an LCD display 212 and keypad 213 on the front surface, a vent 214 for discarding used capsules, and a door 218 . The housing portion 210a includes a section 219 on which electronic components and a microprocessor are mounted. Section 219 is opened for access to the system stop device. The housing portion 210b extends laterally from one side of the housing portion 210a and includes a lid 215 for loading the hypodermic syringe, a door 216 for the label printer 270 (Fig. 15) Lt; RTI ID = 0.0 > 217 < / RTI >

Referring to Fig. 15, the system device 200 has a frame 220 and a platform 221 that support the components as described below.

16 to 18, there is shown a non-movable type conveyor having a plurality of chambers 232 disposed around the circumference of the rotary conveyor body 231 in the housing part 210a and extending from the top of the rotary conveyor 231 to the bottom, An inventory structure having a rotating conveyor is disposed. The chamber 232 supports a capsule 202 containing a plurality of medicines in a bottom-up arrangement from the top. Each of the capsules has a prolate body portion 203 made of rigid plastic, which is flexible or rigid. However, the end 204 of the capsule is comprised of an elastic film, such as rubber, that is easily pierced by the hypodermic needle to allow delivery of the drug from the capsule 202 to the hypodermic syringe. The chamber 232 is radially oriented to support a laterally elongated capsule such that the end 204 of the capsule is radially outwardly directed. The chamber 232 has a linear shape and / or a zigzag shape. Because of the zigzag shape, more capsules can be stored than the linear shape, and the movement of the capsules is better controlled. In the embodiment shown in FIG. 18, the channel 232 is a zigzag shape.

23, a working cylindrical plate 241 is disposed below the rotary conveyor 231, which includes a plurality of notches 242 disposed in the circumference of the plate 241, and each notch 242 242 are configured and dimensioned to support one capsule 202 in a radial configuration. The notch 242 is aligned with the channel 231 so that the capsules 202 at the bottom of the channel fall into the corresponding notches. The actuating cylindrical plate is rotatable and moves the selected capsule to the treatment area as described below. The capsule is rotated or slid on the blocking plate 243 below the cylindrical plate 241 which operates when the actuating plate 241 rotates.

23, 24, 26 and 27, a non-rotating interruption plate 243 is disposed below the actuating cylindrical plate 241 to prevent the capsules 202 of the notches 242 from falling out of the notches desirable. However, the blocking plate 243 includes a gate 244 that is movable between a closed position and an open position. When the gate 244 is in the open position and the notch 242 is aligned with the gate 244, any capsule of the notch will fall through the gate into the used capsule waste bin 280. Thus, after the drug is withdrawn from the capsule, the actuation plate is rotated to move the notch with the used capsule aligned to the gate 244, and the gate 244 is opened, 200 to be discarded into a capsule waste bin 280 that is subsequently used for discarding. The motor 246 disposed below the platform 221 of the housing part 210a (Fig. 15) rotates the cylindrical plate 241 which operates in response to the operation instruction.

19 to 22, the housing part 210b includes means for perforating the capsule and withdrawing medicine therefrom. In particular, the hypodermic syringe support frame 260 receives and actuates the hypodermic syringe 290 while activating the hypodermic syringe to withdraw the medicament directly from the capsule to the syringe chamber 294. The syringe 290 is first provided with a protective cap 293 covering the hypodermic needle 291 to prevent sudden needle sticking (see FIG. 19). 25A-25G, the syringe 290 is first loaded with the support frame 260, the syringe chamber 294 is secured to the support frame 160, and the end of the syringe plunger 292 is secured to the plunger (264). The subcutaneous syringe support frame 260 is moved forward by the first linear actuator 261 from the first loading position to the second position where the cap removal 263 is connected to the protective cap 293 (Figure 25B) Respectively. The solenoid 262 actuates the gripping mechanism of the cap remover 263 to releasably engage the cap 293. The linear actuator 261 moves the hypodermic syringe 290 in a reverse direction to a third position to separate the protective cap 293 from the hypodermic syringe 290 (Figure 25C). The cap removing unit 263 is moved upward by the second linear actuator 265 so that there is no further advance of the hypodermic syringe 290 (see FIG. 25D). The first linear actuator 261 advances the hypodermic needle to a fourth position in which the hypodermic needle punctures the end 204 of the capsule 202 containing the drug in the treatment region (see FIG. 25E). The plunger grasper 264 is moved backward by a third linear actuator 266 to form a negative pressure in the syringe chamber 294 to withdraw the drug from the capsule 202 to the subcutaneous injector 290 (See Fig. 25F). The amount of solution delivered is controlled by the travel distance of the plunger 292 in view of the volume of the loaded syringe chamber 294. The first linear actuator 261 then moves the hypodermic syringe 290 back to the fifth position to withdraw the needle 291 from the process region. 27, the actuation plate 241 is then rotated to position the capsule 202 used on the gate 244, which is then opened to drop the capsule used as the waste bin 280. As shown in FIG. If another capsule is used, the actuating cylindrical plate 241 is moved to position the new capsule in the treatment area for puncturing by the subcutaneous needle 291, and the above-described procedure is repeated. In addition, if no capsule is used, the cap holder 263 is lowered to a position where the protective cap 293 is aligned with the needle 291. Subsequently, the hypodermic syringe is advanced again to connect the subcutaneous needle 291 and the protective cap 293, and the protective cap 293 is then released, and the first linear actuator is moved back to the entire hypodermic injector 290). The user can remove the loaded hypodermic syringe, which is ready for injection therapy for the patient. The label printer 270 can print the label associated with the hypodermic syringe 290 so that the contents of the hypodermic syringe 290 and the patient can be confirmed and other information is also printed. The information may be printed in the form of text, bar code or QR code.

Referring to Figures 28-34B, another embodiment 300 of the present invention is shown.

28, the housing 310 includes a lead 311 on the upper surface for encapsulation, an LCD display 312 and a keypad 313 on the front surface, a door 317 for discarding the used capsules, a vent 314 A door 318 for the treatment of the waste solution, a transparent cover wall 315 and a door 316 that allows access to the inner chamber 322 for placement of the product vial 390. The product vial 390 is disposed in the chamber 322 above the fluid drain 382 for the fluid used. The housing 310 has an operating section 319 on which electronic components and a microprocessor are mounted.

29A and 29B, the system device 300 includes a platform 321 and a frame 320 for supporting the components described below. 30, the housing 310 is provided with a non-movable rotary conveyor body (not shown) having a plurality of chambers 332 disposed in the circumference of the round conveyor body 331 and extending from the top of the rotary conveyor body 331 to the bottom 331) is disposed. The chamber 332 supports a plurality of capsules 302, each containing a drug in a top-to-bottom array. Each of the capsules has a substantially cylindrical body portion 303 made of a rigid pierced plastic that can be flexible or rigid. However, the end 302 of the capsule is comprised of an elastic film, such as rubber, that is easily perforated by the hypodermic needle to allow delivery of the drug from the capsule 302 to the product vial 390 (see Figures 33A and 33B) ). The chamber 332 is configured to support a radially oriented, laterally extending capsule 302 such that the end 302 of the capsule is radially outward. In one embodiment, the chambers 232 may be zigzag shaped, although they may be linear, partially linear, or partially zig-zag-shaped.

31, there is disposed a means for moving the capsule and selecting the capsule below the rotating conveyor body 331 into a treatment area comprising a working cylindrical plate 341, , Each notch being configured and dimensioned to support a single capsule 302 in a radial configuration. The notch 342 may be aligned with the channel 331 to cause the lowest portion of the capsule 302 to fall into the corresponding notch 342 in the channel. The notch 342 preferably includes an inwardly oriented ridge 342a that limits the radial opening 342b of the notch to prevent the capsule 302 from sliding out of the opening 342b. The actuating cylinder plate 341 is rotatable and moves the selected capsule to the treatment area as described below. The capsule rotates or slides on the blocking plate 343 below the actuating cylindrical plate 341 when the actuating plate 341 rotates.

It is preferred that a non-rotating interruption plate 343 is disposed below the working cylindrical plate 341 to prevent the capsules 302 of the notches 342 from falling from the bottom of the notches 342. However, the blocking plate 343 includes a gate 344 that is movable between a closed position and an open position. When the gate 344 is in the open position, the notch 342 is aligned with the gate 344 and any capsule of notches passes through the gate 344 and through the opening 381 of the platform 321 And then drops into the capsule waste bin 380 where the capsule is disposed. Thus, after the drug is withdrawn from the capsule 302, the actuation plate 341 is rotated to move the notch 342 so that the used capsule is aligned with the gate 344, and the gate 344 is then opened The used capsule is discarded into the capsule waste bin 380 used to be subsequently removed from the system device 300 through the door 317 of the housing. The motor 346 disposed under the platform 321 of the housing part 310 (Fig. 29A) rotates the working cylindrical plate 341 in response to the operation instruction.

Referring to Figures 31, 32A, 32B, 33A, and 33B, a working cylinder plate rotates to move the selected capsule 302 into a processing region aligned with the means for perforating the capsule and delivering the drug from the capsule to the product vial . More specifically, the apparatus 300 includes an extraction needle 361 which is configured to allow the extraction needle to pierce the end 304 of the capsule from a position where the extraction needle is spaced from the end 304 of the capsule Position by the solenoid 362. The medicament is withdrawn from the capsule at negative pressure through fluid line 371. The pinch valve 372 regulates fluid flow through the fluid line 371. 33A and 33B, the scanning nozzle 374 and the vacuum channel 375 mounted on the piston 377 are connected to the product vial chamber 322 (Fig. 28 (b)) to propagate negative pressure to withdraw the drug, And the scanning nozzle 374 and the vacuum channel 375 are separated from the upper position where the scanning nozzle 374 and the vacuum channel 375 are separated from the product vial 390 Is moved by the linear actuator 373 (Figs. 29A and 29B) to a lower position penetrating the rubber seal at the upper end 391 of the product vial 390 (Figs. 33A and 33B). The vacuum channel 375 may be shorter than the scan nozzle 374. In one embodiment, the scanning nozzle can move laterally to align the scanning nozzle with the product vial. The vacuum channel 375 is connected to a vacuum pump 376 (FIGS. 32A and 32B) by a vacuum line, which operates to introduce a vacuum into the interior of the product vial 390. This vacuum introduces fluid medicament from the capsule 302 into the product vial through the fluid line 371 and the scanning nozzle 374. The amount of solution delivered can be controlled by the delivery time controlled by the valve 372 and the power of the vacuum pump 376. When the contents of one capsule are transferred, it moves over the gate 344 and falls into the used capsule waste bin 380. If another capsule is used, the process is repeated. If the capsule 302 is no longer used, the scanning nozzle 374 is withdrawn upward and the product vial 390 is moved to the product vial chamber 322 that does not cover the fluid drain 382 of the product vial chamber 332, .

Referring to Figures 34A and 34B, the system is cleaned with sterile cleaning fluid. The scan nozzle 374 is moved downward to at least partially enter the fluid drain 382. A capsule 302 containing, for example, a cleaning fluid of ethanol and / or deionized sterile water is punched as described above and the pressure forces the cleaning fluid through the system, (Not shown) through a fluid drain 382 having a rubber film which is exited and punctured by the scanning nozzle. The spent fluid accumulated in the container is removed through the through-door 318 and discarded. The annular recess around the inlet of the fluid drain 382 is dimensioned to accommodate the bottom of the product dispenser to function as a dispenser retainer to stabilize the product dispenser.

In an alternative embodiment of the system device 300, the entire capsule containing the medicament may be pressurized. In this alternative embodiment, the vacuum pump 376 and the vacuum pump 375 may be configured such that withdrawal of the medicament can be achieved with a positive pressure, although such an alternative may be similar to the embodiment 300 described above. It can be omitted. The amount of the delivered solution can be controlled by the valve 372 because the pressure inside the capsule is predetermined and packaged.

35, in one embodiment, the capsule, shown as capsule 503, has a rectangular body with an elliptical section 503a and an end portion 503b of resilient rubber material.

Figure 36 shows applying positive pressure in a direction perpendicular to the capsule to withdraw the drug from the capsule. The capsule 504 is firmly supported between the jaws 511a and 511b of the clamping mechanism 511.

37A and 37B illustrate applying a positive lateral pressure to the capsule to withdraw medicament from the capsule by the jaws 512a, 512b of the caliper mechanism. In Fig. 37A, the jaws 512b are fixed while the jaws 512b are moving and applying pressure to the capsules 504. 37B, the jaws 512a and 512b are moved.

38 illustrates placing the sensor 520 in the apparatus 100 to monitor the amount of the capsule loaded into the rack < RTI ID = 0.0 > 131. < / RTI >

39 shows the placement of a sensor 521 that monitors the capsule loaded down the rack 131 at the gate 414, which is a loading slide.

40 shows the placement of the sensor 522 along the guide channel 154 to monitor the loaded capsule at the belt 515 which is a conveyor system and places the sensor 523 in the process area where the capsule is pushed and perforated Lt; / RTI >

Figure 41 shows the placement of a sensor 524a monitoring the lifting of the product dispenser 103 on the loading platform 161 by the crank 162 to puncture the capsule.

42 shows the placement of a sensor 524b for monitoring the lateral movement of the product dispenser 103 on the loading platform 161. [

Figures 43A, 43B, 43C and 43D illustrate the use of sensors 525, 526, and 528 in lid 11, printer door 114, capsule discard door 117 and medicament loading door 119, respectively, to monitor the open or closed position of the door. 527, and 528, respectively.

Figure 44 illustrates loading of the channel member 132 in the linear notch 531 of the inventory structure 530 in the form of a rotating conveyor instead of the vertical rack 131. [

While the foregoing description includes various types, these classes are not to be construed as limiting the invention, but merely as preferred examples. Those skilled in the art will envision other embodiments within the scope of the present invention as defined by the appended claims.

100: System unit 111: Lead
112: Screen 113: Keypad
110: housing 114: door
115: Slot 117: Door
170: Connector cap

Claims (28)

A system for preparing a medicament for injection therapy for a patient,
a) a housing surrounding the inner space;
b) an inventory structure comprising a plurality of chambers individually supporting one or more disposable capsules containing the drug, wherein each capsule has a liquid volume of 0.1 to 10.0 mL;
c) capsule selection means for selecting and dropping the capsule according to the predetermined medicine contained in the capsule;
d) capsule moving means disposed below the capsule selecting means for moving the capsule selected as the treatment region;
e) drug delivery means for sequentially delivering a controlled quantity of the predetermined medicament by direct fluid communication from each selected capsule to the product container under the action of a positive or negative pressure;
f) means for dropping and automatically discarding the used capsule from which the drug is removed after a single use,
Wherein the system is configured to limit the capsule to a single use,
Characterized in that the medicament delivery means comprises means for mechanically pressing the capsule to regulate the amount of medicament delivered by providing a positive external pressure to move the medicament from the capsule through the needle to the product container Or a pharmaceutically acceptable salt thereof. The method according to claim 1,
Further comprising means for puncturing the selected capsule in the treatment area. ≪ Desc / Clms Page number 20 > The method according to claim 1,
Wherein the chamber of the inventory structure comprises a plurality of vertical racks for individually supporting a plurality of channel members, each channel member supporting a plurality of capsules in a vertical arrangement, each channel member having a bottom end Or a pharmaceutically acceptable salt thereof. The method of claim 3,
The capsule selection means comprises a capsule separation mechanism at the bottom end of each channel, the capsule separation mechanism comprising a first position in which the bottom end of each channel is closed to prevent the capsule from passing through the bottom end of the channel, And a second position in which the bottom end of the channel is open to allow the capsule to pass therethrough. The method according to claim 1,
Wherein the means for moving the selected capsule to the treatment region comprises a linear delivery system. 3. The method of claim 2,
The product container is a product container,
The means for perforating the capsule,
A cap attached to the product dispenser and having a needle and an air vent;
And a mechanism for puncturing the capsule with the needle. delete The method according to claim 1,
Wherein the means for disposing of the used capsules comprises a waste bin disposed within the housing in which the capsules used fall. The method according to claim 1,
Characterized in that the inventory structure comprises a non-movable rotary conveyor, the chamber being arranged around a circumference of the rotary conveyor, the capsule being arranged in a linear channel member arranged in the chamber or removably inserted in the chamber Or a pharmaceutically acceptable salt thereof. 10. The method of claim 9,
Characterized in that the chamber is linear or zigzag shaped. 10. The method of claim 9,
Wherein the capsules are elongated cylindrically or prolate and are oriented in a horizontal direction or in a vertical direction within each chamber. 3. The method of claim 2,
Wherein the means for perforating the capsule includes an extraction needle movable between a first position and a second position wherein the extraction needle punctures the end of the capsule selected to be sufficient to withdraw the medicament from the capsule Preparing system. 10. The method of claim 9,
And a scanning system disposed within the housing, the scanning system including a scanning nozzle movable between an initial upper position and a lower position for insertion into a product container. 14. The method of claim 13,
Wherein the scanning nozzle is moved laterally. ≪ Desc / Clms Page number 13 > 14. The method of claim 13,
Further comprising a vacuum conduit associated with said scan nozzle. ≪ Desc / Clms Page number 20 > 14. The method of claim 13,
Wherein the means for cleaning the scanning system to dispose of the generated waste comprises a drain to the waste solution container within the housing. 17. The method of claim 16,
Further comprising means for cleaning the scanning system,
Wherein the means for cleaning the scanning system comprises a capsule containing an aseptic cleaning fluid comprising ethanol or deionized sterile water. 16. The method of claim 15,
Characterized in that the system further comprises a vacuum pump. The method according to claim 1,
Wherein the product container is a hypodermic syringe having a needle attached to one end, a plunger, and a removable cap covering the needle,
Wherein the medicament delivery means comprises a mounting means for supporting the hypodermic syringe, the mounting means being movable between a first position in which the hypodermic syringe is spaced from the selected capsule and a second position in which the needle punctures the capsule Wherein the means for gripping and pulling the plunger of the hypodermic syringe further comprises means for removing the cap. ≪ RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
Further comprising a UV germicidal lamp disposed within the housing. ≪ Desc / Clms Page number 13 > The method according to claim 1,
Wherein the medicament comprises at least one of a certain amount of vitamin, growth hormone, glucosamine, omega-3 fatty acid, onabotryntotoxin A, and insulin. The method according to claim 1,
Wherein the capsule and the chamber are color coded. The method according to claim 1,
Further comprising a plurality of sensors disposed within the housing to monitor operation of the capsule inventory and system. ≪ RTI ID = 0.0 >< / RTI > The method according to claim 1,
≪ / RTI > further comprising a label printer. The method according to claim 1,
Wherein the capsule is pressurized. The method according to claim 1,
Further comprising input and output unit information. ≪ RTI ID = 0.0 > 8. < / RTI > The pharmaceutical preparation according to claim 1, wherein the medicament comprises at least one of vitamin, growth hormone, glucosamine, omega-3 fatty acid, onabotryntotoxin A and insulin, and the patient is human or animal system. CLAIMS 1. A method for preparing a medicament for an addiction treatment to a patient,
a) storing a plurality of capsules containing a drug in an inventory structure;
b) selectively dropping one or more capsules according to the drug contained therein;
c) perforating the selected capsule with an extraction device;
d) withdrawing a predetermined amount of the drug from the capsule selected under the condition that a positive pressure or negative pressure is applied, and delivering the withdrawn drug to the product container;
e) dropping and discarding the used capsule from which the drug is withdrawn after using the capsule once,
The method requires that the capsule be limited to single use,
The step of delivering the medicament to the product container comprises mechanically pressing the capsule to adjust the amount of medicament delivered by providing a positive external pressure to move the medicament through the needle from the capsule to the product container, ≪ / RTI >

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