KR101938376B1 - Systems and method for managing web-based clinical trial medical imaging and program therefor - Google Patents

Abstract

The present invention provides a web-based method for managing a clinical trial medical image that integrates and manages clinical trial medical images on a web basis to prevent loss and loss of image data and verify integrity or stability. The present invention provides a method comprising: a first local computer acquiring an image charter and a clinical trial medical image; Verifying the obtained clinical trial medical image by a plug-in program installed in the first local computer; The first local computer accessing a web case record (eCRF) system of the server to upload the validated clinical trial medical image; The server classifying the clinical trial medical images and transmitting them to a second local computer; Analyzing the clinical trial medical image by a plug-in program installed in the second local computer; Connecting the second local computer to the server to upload the analyzed clinical trial medical image; Collecting the analysis results of the uploaded clinical test medical images and storing them in a database; And transmitting the analysis result of the clinical trial medical image to the first local computer by the server.

Description

[0001] SYSTEMS, METHODS, AND PROGRAMS FOR MANAGING CLINICAL TEST MEDICAL IMAGES [0002]

The present invention relates to a system, a method, and a program for managing clinical test medical images for managing numeric data and image data together in a clinical test process using a local computer connected to an online server.

In recent clinical trials, the importance of using image data for drug efficacy evaluation of new drugs has been increasingly emphasized. In particular, the development of targeted anticancer drugs and immunotherapeutic agents is accelerated, and in addition to the evaluation of efficacy based on existing tumor sizes, evaluation of efficacy using functional and molecular imaging biomarkers becomes very useful and important.

In addition, as these imaging biomarkers become more numerous and imaging data become more widespread, the need for clinical trial medical imaging management is increasing in clinical trials or preclinical trials.

Thus, although the importance of image data is increasing in clinical trials, a system capable of managing and integrating image data and numerical data in clinical data processing has not been provided.

Accordingly, conventionally, video data is uploaded to a separate web page of the server or is sent by courier using CD / DVD. In this process, since the upload failure and the loss of video data due to loss of CD / DVD frequently occur There is a problem that transmission and management of image data is difficult and loss and loss of image data are high.

In addition, it is troublesome to perform a central review only at a designated time and place, and there is a problem that it is difficult to store the image data acquired in clinical trials.

Korean Registered Patent No. 10-1604086 (Mar. 10, 2016)

The problem to be solved by the present invention is to verify the integrity or stability of data by integrally managing clinical trial medical images and web case records (eCRF) using a web-based plug-in program, And to provide a method for managing test medical images.

In addition, the present invention provides a method for managing a clinical test medical image in a web-based manner that can collectively perform anonymization and automatic transmission of a medical image and confirmation of results.

In addition, it is possible to manage the clinical trial medical image by web-based method that can read the image anytime and anywhere without restriction of time and place and provide long-term archiving and smooth backup of the acquired image data .

The problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems which are not mentioned can be clearly understood by those skilled in the art from the following description.

According to another aspect of the present invention, there is provided a method of managing a clinical test medical image using a Web, the method comprising: acquiring an image charter and a clinical test medical image by a first local computer; Verifying the obtained clinical trial medical image by a plug-in program installed in the first local computer; The first local computer accessing a web case record (eCRF) system of the server to upload the validated clinical trial medical image; The server classifying the clinical trial medical images and transmitting them to a second local computer; Analyzing the clinical trial medical image by a plug-in program installed in the second local computer; Connecting the second local computer to the server to upload the analyzed clinical trial medical image; Collecting the analysis results of the uploaded clinical test medical images and storing them in a database; And transmitting the analysis result of the clinical trial medical image to the first local computer by the server.

Wherein the image charter includes at least one of an image capturing method, an image thickness, and an image parameter, and wherein the verifying the clinical test medical image comprises: The plug-in program of the first local computer compares the item of the DICOM header of the clinical trial medical image with the item set in the image charter, and verifies whether it satisfies a specific reference value (Quality Assurance) desirable.

Items of the DICOM header to be checked in the verification step are predetermined in the image charter creation step, and the integrity or stability of the clinical trial medical image can be verified through the verification step.

 Analyzing the clinical trial medical image comprises: The plug-in program installed on the second local computer displays the clinical trial medical image on a screen; (Quality Assurance) of the image quality including the degree of image blurring and noise of the clinical test medical image; Analyzing the clinical test medical image through the analysis tool and checking the items of the DICOM header together with the clinical test medical image to determine whether the predetermined reference value is satisfied, .

Setting a region of interest (ROI) in the clinical test medical image by the second local computer; The plug-in program of the second local computer analyzing the region of interest, extracting a web case record form item and uploading it to the server; And inputting contents of the uploaded form item based on information stored in the web case recording system of the server.

The server may further include a step of capturing the medical image displaying the analysis result of the region of interest and merging the captured medical image into the web case recording form.

The second local computer comprises a plurality of second local computers for each institution, and a plug-in program installed in the plurality of second local computers can individually analyze the clinical trial medical images and upload them to the server.

Before the plug-in program of the first local computer uploads the validated clinical trial medical image to the server; Extracting and anonymizing personal information from the clinical trial medical image.

The step of anonymizing the personal information comprises: Extracting the personal information by analyzing the DICOM header information of the clinical trial medical image, and separating the deletion object information and the maintenance object information; And deleting the deletion object information from the clinical trial medical image, wherein the deletion object information is information including an individual identification item or a file name in the header information.

The plug-in program installed in the first local computer may further include image processing the acquired clinical trial medical image to generate an analyzed medical image.

Another aspect of the present invention provides a clinical trial medical image management program stored in a recording medium for executing a method for managing a clinical trial medical image on a web basis, in combination with a hardware computer, can do.

Other specific details of the invention are included in the detailed description and drawings.

According to the web-based clinical image management method of medical image management according to the present invention, it is possible to prevent loss and loss of image data and to verify integrity or stability by integrating and managing clinical trial medical images between a local computer and a server There is an effect.

In addition, an anonymization and automatic transmission of a medical image and confirmation of a result can be performed all at once.

In addition, it is possible to read the image anytime and anywhere without restriction of time and place, and it is also possible to provide long-term storage and smooth backup service of the image data acquired in the clinical trial.

The effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

FIG. 1 is a network system configuration diagram for implementing a method for managing a clinical trial medical image on a web-based basis according to an embodiment of the present invention.
FIG. 2 is a flowchart illustrating a method of managing a clinical trial medical image on a web-based basis according to an embodiment of the present invention.
Figure 3 is a flow chart detailing the steps of analyzing a clinical trial medical image by the second local computer of Figure 2;
FIG. 4 is a flowchart illustrating in detail a step of setting a region of interest in a clinical test medical image and extracting a form item from the second local computer of FIG. 2;
FIG. 5 is a flow chart illustrating in detail the step of the first local computer of FIG. 2 anonymizing person identification information from a clinical trial medical image and generating an analyzed medical image according to image processing;
6 is a view showing a screen of a web case recording system according to an embodiment of the present invention.
FIG. 7 is a flowchart showing an example of application of the system of the present invention in a clinical test process in connection with the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. It should be understood, however, that the invention is not limited to the disclosed embodiments, but may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, Is provided to fully convey the scope of the present invention to a technician, and the present invention is only defined by the scope of the claims.

The terminology used herein is for the purpose of illustrating embodiments and is not intended to be limiting of the present invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. The terms " comprises "and / or" comprising "used in the specification do not exclude the presence or addition of one or more other elements in addition to the stated element. Like reference numerals refer to like elements throughout the specification and "and / or" include each and every combination of one or more of the elements mentioned. Although "first "," second "and the like are used to describe various components, it is needless to say that these components are not limited by these terms. These terms are used only to distinguish one component from another. Therefore, it goes without saying that the first component mentioned below may be the second component within the technical scope of the present invention.

Unless defined otherwise, all terms (including technical and scientific terms) used herein may be used in a sense that is commonly understood by one of ordinary skill in the art to which this invention belongs. In addition, commonly used predefined terms are not ideally or excessively interpreted unless explicitly defined otherwise.

The terms spatially relative, "below", "beneath", "lower", "above", "upper" And can be used to easily describe a correlation between an element and other elements. Spatially relative terms should be understood in terms of the directions shown in the drawings, including the different directions of components at the time of use or operation. For example, when inverting an element shown in the figures, an element described as "below" or "beneath" of another element may be placed "above" another element . Thus, the exemplary term "below" can include both downward and upward directions. The components can also be oriented in different directions, so that spatially relative terms can be interpreted according to orientation.

In the present invention, an image can be easily transmitted to an online system (eCRF) through a plug-in program (CTIMS) installed in a local PC and the transmission result can be immediately checked. For example, if you click on the list of online systems, the corresponding DICOM image is displayed on the viewer of the local computer, and the QC (quality check) and various measurements are performed. Transmission becomes possible.

Hereinafter, features according to embodiments of the present invention will be described in detail with reference to FIGS. 1 to 7 attached hereto.

FIG. 1 is a network system configuration diagram for implementing a method for managing a clinical trial medical image on a web-based basis according to an embodiment of the present invention.

1, a network system for implementing a web-based clinical test medical image management system according to the present invention includes a first local computer 100, a server 200, a database 210, And a plurality of second local computers (300).

The first local computer 100 acquires the clinical trial medical image of the patient. To this end, the present invention is equipped with conventional medical imaging equipment (not shown) for acquiring medical images. Such medical imaging apparatuses include, for example, a computed tomography (CT) apparatus for capturing an anatomical image of the inside of a human body using X-rays of radiation, a magnetic resonance imaging apparatus for reconstructing the signal by high- PET (Positron Emission Tomography), which reconstructs three-dimensional images of the physiological reactions that occur in each part by injecting radiopharmaceuticals that emit positron into the human body, and a PET device (Magnetic Resonance Imaging) A CT-combined PET-CT device, a PET-MR device that combines the high image quality of PET with the superior resolution of MRI, and an electroencephalography (EEG) device for brain wave measurement.

The first local computer 100 may be, for example, a hospital, a picture archiving communication system (PACS) (not shown). Hospital PACS enables image storage and transmission of CT images, MRI images, PET images, PET-CT images, PETMR images, and EEG images acquired from medical imaging equipment. The PACS collects medical image images acquired from the medical image equipment and stores them in a memory, and transmits the medical images collected in response to the request of the medical image to the server 200 of the present invention.

And may be constituted by a server device and a client device for carrying out the web-based program of the present invention.

The client device corresponds to the first local computer 100, and refers to a device held by a user who executes a calculation process, in which a specific program is included or installed. The 'client device' includes various devices capable of performing computation processing and providing results to a user. For example, the computer may be a smart phone, a tablet PC, a cellular phone, a personal communication service phone (PCS phone), a synchronous / asynchronous A mobile terminal of IMT-2000 (International Mobile Telecommunication-2000), a Palm Personal Computer (PC), a personal digital assistant (PDA), and the like.

FIG. 2 is a flowchart illustrating a method of managing a clinical trial medical image on a web-based basis according to an embodiment of the present invention.

Referring to FIG. 2, a method for managing a web-based clinical test medical image according to the present invention includes the steps of acquiring an image charter and a clinical trial medical image from the first local computer 100 (S010); The plug-in program installed in the first local computer 100 verifies the obtained clinical trial medical image (S020); The first local computer 100 accesses the web case recording (eCRF) system of the server 200 to upload the verified clinical trial medical image (S030); (S040) the server 200 classifies the clinical trial medical images and transmits them to the second local computer 300; Analyzing the clinical trial medical image by a plug-in program installed in the second local computer 300 (S050); The second local computer 300 accesses the server 200 and uploads the analyzed clinical trial medical image (S060); (S070) the server 200 collects the analysis results of the uploaded clinical trial medical images and stores them in the database 210; And the server 200 transmits the analysis result of the clinical test medical image to the first local computer 100 in operation S080. The first local computer 100 analyzes the analysis result of the clinical trial medical image (Step S090).

The operation of the web-based clinical image management method according to an embodiment of the present invention will now be described.

First, the first local computer 100 acquires a patient's image charter and a clinical trial medical image (S010).

The first local computer 100 may be, for example, a hospital PACS and may acquire images of a CT image, an MRI image, a PET image, a PET-CT image, a PETMR image, and an EEG image in a medical imaging device.

Generally, when starting a clinical trial, a standard called image charter is created by a pharmaceutical company (sponsor), a CRO (clinical trial agent), and a clinical trial center. This image charter will detail the entire process of the clinical trial, including what images to take, how to capture the images (what protocol to take), how to transfer data, how to analyze them, and so on. At this time, the image capturing method, the thickness of the image, and the parameters of the image are also determined in detail.

Therefore, the image charter of the present invention preferably includes at least one of an image capturing method, an image thickness, and an image parameter.

Thereafter, the plug-in program installed in the first local computer 100 verifies the obtained clinical trial medical image (S020).

At this time, in the step of verifying the clinical test medical image, the plug-in program of the first local computer 100 compares the item of the DICOM header of the clinical test medical image with the item set in the image charter and determines whether the specific reference value is satisfied (Quality assurance).

In particular, the items of the DICOM header to be checked in the verification step are predetermined in the image charter creation step, and it is preferable that the integrity or stability of the clinical trial medical image is verified through the verification step.

The verification (QA) step applied in the present invention is to check the DICOM header item to check whether these minimum parameters are satisfied first when the client transmits an image, and to transmit the image only when all the parameters are satisfied. In the case of data that does not satisfy the predetermined minimum criterion, the transmission itself is not performed and the function of maintaining the minimum quality of the clinical test data is performed.

The integrity or stability defined in the present invention means the integrity or stability of the medical image data. The integrity or stability defined in the present invention refers to the maintenance and assurance of data accuracy and consistency over a complete life cycle in the field of computing. Lt; / RTI >

The integrity of medical image data is generally enforced by a set of integrity constraints or rules. These kinds of integrity constraints can be seen as part of the basic functionality of the relational data model.

For example, (Entity integrity) relates to the concept of (unique key). Entity integrity states that all tables must have a primary key, that the columns selected with the primary key must be unique, and that empty values are unacceptable.

Referential integrity is related to the concept of (foreign key). The referential integrity rule specifies that all foreign key values fall into only one of the two states. A common condition is that the foreign key value refers to the primary key value of a particular table in the database. Occasionally this can be done according to the rules of the business, and foreign key values allow an empty value.

Domain integrity specifies that all columns in the relational database are declared in the defined scope.

As an example of the present invention, a method of checking whether a medical image is normal can be applied based on a hash value, and integrity and stability can be verified by techniques such as code obfuscation, reversing, and anti-debugging as well as hash value analysis have.

Figure 3 is a flow chart detailing the steps of analyzing a clinical trial medical image by the second local computer of Figure 2;

Referring to FIG. 3, analyzing the clinical trial medical image includes: A plug-in program installed in the second local computer 300 displays the clinical trial medical image on the screen (S051); (S052) of checking quality of an image including the degree of image blurring and noise of the clinical test medical image (Quality Assurance); Analyzing the clinical test medical image through the analysis tool, and checking the items of the DICOM header together with the clinical test medical image to determine whether the predetermined reference value is satisfied (step < RTI ID = 0.0 > S053).

The step of confirming the image quality (QA) (S052) may be performed by the client using the second local computer 300 as described above so as to minimize the parameters (image capturing method, image thickness, ) Is satisfied is checked and checked in the item of the DICOM header, and the video can be transmitted only when all of them are satisfied.

In addition, the QC defined in the present invention is a system in which, after data is transmitted to a central system in an actual clinical testing process, a person in charge of QC (QC) displays the image directly in a computer viewer, , The degree of noise, and the like. Only the images passed in the QC stage are used to analyze the clinical trial results.

FIG. 4 is a flowchart illustrating in detail a step of setting a region of interest in a clinical test medical image and extracting a form item from the second local computer of FIG. 2;

Referring to FIG. 4, the present invention may include a step (S054) of the second local computer 300 setting a region of interest (ROI) in the clinical trial medical image; The plug-in program of the second local computer 300 analyzes the region of interest, and extracts a web case recording form item and uploads it to the server 200 (S055); And inputting the contents of the uploaded form item based on the information stored in the web case recording system of the server 200 (S056).

More specifically, the second local computer 300 sets an ROI in the clinical trial medical image (S054).

For example, when a specific medical image is displayed on the screen of the second local computer 300 and the user sets a specific area of interest of the image, the size and rotation of the color area feature value and shape of the existing image in the database It is possible to search for an image similar to a region of interest by comparing it with a table storing an invariant moment characteristic value.

Accordingly, as an embodiment of the present invention, after finding the minutiae of the medical image, it is possible to receive the coordinate value and specify the ROI. It is possible to obtain the value of the coordinates in the region of interest (ROI) and extract the desired content according to the position with the coordinate value.

In the present invention, the plug-in program of the second local computer 300 analyzes the region of interest, extracts a form item, and uploads it to the server 200 (S055).

As an embodiment for extracting the form items of the present invention, a web based case record (eCRF) system can be provided.

The server 200 may automatically input the contents of the form item of the web-based case recording sheet based on the information stored in the web-based case recording system (S056).

Here, when the server 200 inputs the contents of the form item, the server 200 may capture the image displaying the result of the analysis of the region of interest and may merge the captured image data into the web case recording form (S057).

To this end, the present invention can use a conventional image capturing apparatus and can implement an image capturing system using an image capturing program, but the present invention is not limited thereto.

Meanwhile, the second local computer 300 may include a plurality of second local computers 300 for each institution, and a plug-in program installed in the plurality of second local computers 300 may transmit the clinical trial medical images individually And upload it to the server 300.

The plurality of second local computers 300 for each institution may be a system administrator, a sponsor representative, a research supervisor, a researcher, a coordinator, a responsibility coordinator, a video registrant, a video QC person, an image analysis source, And users of each part of the clinical test process can use the function provided by the plug-in program in each second local computer 300 to easily upload and analyze images.

2, the second local computer 300 accesses the server 200 and uploads the analyzed clinical trial medical image (S060)

The server 200 collects the analysis results of the uploaded clinical trial medical images and stores them in the database 210 (S070), and transmits the analysis results of the clinical trial medical images to the first local computer 100 (S080).

Thereafter, the first local computer 100 displays an analysis result of the clinical trial medical image (S090).

The first local computer 100 displays the analysis result of the clinical trial medical image, thereby making it possible to read the image anytime and anywhere without restriction of time and place, Can be provided.

FIG. 5 is a flow chart illustrating in detail the step of the first local computer of FIG. 2 anonymizing person identification information from a clinical trial medical image and generating an analyzed medical image according to image processing;

5, before the plug-in program of the first local computer 100 uploads the verified clinical trial medical image to the server 200 (S030); Extracting and anonymizing personal information from the clinical trial medical image.

The step of anonymizing the personal information comprises: (S021) the plug-in program analyzing the DICOM header information of the clinical trial medical image to extract the personal information, and distinguishing the deletion object information and the maintenance object information; And deleting the deletion object information from the clinical trial medical image (S023).

The DICOM header information may include information such as patient name, scan format, image dimensions, scale, and the like.

Here, the deletion object information may be information including an individual identification item or a file name in the header information.

Also, the maintenance target information may include information such as a scan format, image dimensions, and scale excluding the deletion target information. More specifically, it may include textual information of a file including a file size, a data resolution, and whether the data is compressed, which can be included in the DICOM header information.

In addition, the plug-in program installed in the first local computer may process the acquired clinical trial medical image to generate an analyzed medical image (S024).

Thereafter, the first local computer 100 accesses the web case recording (eCRF) system of the server 200 and uploads the verified clinical trial medical image (S030).

Accordingly, according to the web-based clinical test medical image management method according to the present invention, it is possible to prevent the loss and loss of the image data and to verify the integrity or stability by integrating and managing clinical trial medical images between the local computer and the server can do.

In addition, anonymization and automatic transmission of medical images, confirmation of results can be performed all at once, and images can be read anytime and anywhere without restriction of time and place. Backup service may be provided.

FIG. 6 is a view showing a screen of a web case recording system according to an embodiment of the present invention, and FIG. 7 is a flowchart showing a case where the system of the present invention is applied in a clinical testing process in connection with the present invention.

Referring to FIGS. 6 and 7, the system of the present invention is used in a clinical testing process, and corresponds to a system for connecting various users included in a clinical testing process.

As shown in the figure, when starting a clinical trial, an image charter is created in a sponsor, a CRO (clinical trial agent), a clinical trial center, and the like (S110).

When creating the image charter, the image capturing method, the thickness of the image, and the parameters of the image are also determined.

Next, the system administrator and the development team perform system customization, a process of creating a form, and a process of creating a user account (S120 to S130).

Next, the radiologists of each institution verifies the clinical trial medical image (QA) through a plug-in program installed in the first local computer 100 of the present invention (S140).

As described above, when the client transmits an image, the verification (QA) process checks whether the minimum parameters satisfy the DICOM header, and transmits the image only when all the parameters are satisfied. In the case of data that does not meet the set minimum criterion, it does not proceed with the transmission itself, so that it performs the function of maintaining the minimum quality of the clinical test data.

The plurality of second local computers 300 for each institution may be, for example, the CRC of each institution, the image QC 200 of the second local computer 300, And the user of each part of the clinical test process can perform the image upload and judgment process by using the function provided by the plug-in program in each second local computer 300 (S150 to S160 ).

In the image quality determination (QC) defined in the present invention, after data is transmitted to the central system in the actual clinical testing process, the staff in charge of QC (QC) displays the image directly in the viewer of the computer, Shake, degree of noise, and the like. Only the images passed in the QC stage are used to analyze the clinical trial results.

Thereafter, a plurality of independent image readers and image analysis sources analyze and read the determined image. At this time, the second local computer 300 can easily perform image uploading and analysis according to the function provided by the plug-in program (S170).

Then, the coordinator can finally confirm the image analysis result and access the server 200 through the second local computer 300 to upload the analyzed clinical trial medical image (S180).

As described above, the web-based clinical test medical image management method according to one embodiment of the present invention is implemented as a program (or an application) to be executed in combination with a hardware computer (i.e., a local computer or a server) Can be stored in the medium.

The above-described program may be stored in a computer-readable medium such as C, C ++, JAVA, machine language, or the like that can be read by the processor (CPU) of the computer through the device interface of the computer, And may include a code encoded in a computer language of the computer. Such code may include a functional code related to a function or the like that defines necessary functions for executing the above methods, and includes a control code related to an execution procedure necessary for the processor of the computer to execute the functions in a predetermined procedure can do. Further, such code may further include memory reference related code as to whether the additional information or media needed to cause the processor of the computer to execute the functions should be referred to at any location (address) of the internal or external memory of the computer have. Also, when the processor of the computer needs to communicate with any other computer or server that is remote to execute the functions, the code may be communicated to any other computer or server remotely using the communication module of the computer A communication-related code for determining whether to communicate, what information or media should be transmitted or received during communication, and the like.

The medium to be stored is not a medium for storing data for a short time such as a register, a cache, a memory, etc., but means a medium that semi-permanently stores data and is capable of being read by a device. Specifically, examples of the medium to be stored include ROM, RAM, CD-ROM, magnetic tape, floppy disk, optical data storage, and the like, but are not limited thereto. That is, the program may be stored in various recording media on various servers to which the computer can access, or on various recording media on the user's computer. In addition, the medium may be distributed to a network-connected computer system so that computer-readable codes may be stored in a distributed manner.

The steps of a method or algorithm described in connection with the embodiments of the present invention may be embodied directly in hardware, in software modules executed in hardware, or in a combination of both. The software module may be a random access memory (RAM), a read only memory (ROM), an erasable programmable ROM (EPROM), an electrically erasable programmable ROM (EEPROM), a flash memory, a hard disk, a removable disk, a CD- May reside in any form of computer readable recording medium known in the art to which the invention pertains.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. Therefore, it should be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

100: a first local computer
200: Server
210: Database
300: second local computer

Claims (11)

The plug-in program installed on the first local computer acquiring an image charter and a clinical trial medical image;
Verifying the obtained clinical trial medical image by a plug-in program installed in the first local computer;
The plug-in program installed in the first local computer accesses a web case recording (eCRF) system of the server and uploads the verified clinical trial medical image;
The server classifying the clinical trial medical images and transmitting them to a plug-in program installed in a second local computer;
Analyzing the clinical trial medical image by a plug-in program installed in the second local computer;
The plug-in program installed on the second local computer accesses the server and uploads the analyzed clinical trial medical image;
Collecting the analysis results of the uploaded clinical test medical images and storing them in a database; And
And transmitting the analysis result of the clinical trial medical image to the first local computer by the server,
Wherein analyzing the clinical trial medical image comprises:
Performing a quality assurance of a video quality including a degree of image blurring and a noise of the clinical test medical image, in a plug-in program installed in the second local computer;
Wherein the plug-in program installed in the second local computer checks the items of the DICOM header together with the clinical test medical image to determine whether a predetermined reference value is satisfied, wherein the predetermined reference value is determined based on the image capturing method, The parameter being a predetermined reference value preset for the parameter;
Setting a region of interest (ROI) in the clinical test medical image by a plug-in program installed in the second local computer;
Analyzing the region of interest, and extracting a web case record form item and uploading it to the server, the plug-in program being installed in the second local computer; And
And inputting contents of the uploaded form item based on information stored in the web case recording system of the server,
Wherein the first local computer acquires a clinical trial medical image through the plug-in program,
Wherein the second local computer analyzes the clinical trial medical images through the plug-in program, wherein at least one second local computer is configured for each institution, and a plug-in program installed on the one or more second local computers analyzes the clinical trial medical image Each of which is individually analyzed and uploaded to the server
How to manage medical images on a web based clinical trial. The method according to claim 1,
Wherein the image charter includes at least one of an image capturing method, an image thickness, and an image parameter,
Verifying the clinical trial medical image comprises:
The plug-in program of the first local computer compares the item of the DICOM header of the clinical trial medical image with the item set in the image charter and verifies whether it satisfies a specific reference value (Quality Assurance)
How to manage medical images on a web based clinical trial. 3. The method of claim 2,
The items of the DICOM header to be checked in the verification step are predetermined in the image charter creation step,
And verifying the integrity or stability of the clinical test medical image through the verification step
How to manage medical images on a web based clinical trial. delete delete The method according to claim 1,
Further comprising the step of the server capturing the medical image displaying the analysis result of the region of interest and merging the medical image into the web case recording form
How to manage medical images on a web based clinical trial. delete The method according to claim 1,
Before the plug-in program of the first local computer uploads the validated clinical trial medical image to the server;
Further comprising extracting and anonymizing personal information from the clinical trial medical image
How to manage medical images on a web based clinical trial. 9. The method of claim 8,
The step of anonymizing the personal information comprises:
Extracting the personal information by analyzing the DICOM header information of the clinical trial medical image, and separating the deletion object information and the maintenance object information;
And deleting the deletion object information from the clinical trial medical image,
The deletion object information is information including an individual identification item or a file name in the header information
How to manage medical images on a web based clinical trial. The method according to claim 1,
Wherein the plug-in program installed in the first local computer further comprises image processing the acquired clinical trial medical image to generate an analyzed medical image
How to manage medical images on a web based clinical trial. A clinical test medical image management program stored in a recording medium for executing the method of any one of claims 1 to 3, 6 and 8 to 10 in combination with a computer which is hardware.

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