KR101933692B1 - Diagnostic kit comprising biomarkers for polychlorinated biphenyl 77 exposure diagnosis - Google Patents

Abstract

The present invention relates to a polychlorinated biphenyl 77 exposure diagnostic kit comprising: a base sequence of following genes; or complementary base sequence thereof: MYC, HSP90AB1, AARS, LGALS1, UBC, RPS3, HSPA5, P4HB, DNAJA3, GPI, FOXO3, BCAP31, TNFAIP3, NQO1, RASA1, DNAJB6, SIRT1, LAMTOR5, PPARG, ASNS, BIRC2, HSPD1 and SOS1.

Description

{Diagnostic kit containing biomarkers for polychlorinated biphenyl 77 exposure diagnosis}

The present invention relates to a diagnostic kit comprising a biomarker capable of accurately diagnosing exposure of polychlorinated biphenyl 77 and a method for providing exposure information of polychlorinated biphenyl 77 using the same.

Polychlorinated biphenyl (PCB) is an organic chlorinated compound with high thermal conductivity, low flammability and high resistance to thermal degradation. Therefore, it has been widely used in electric insulators, electric transformers and large capacitors as well as plasticizers, pressure-sensitive copiers, working fluids, paint additives and lubricants. However, they tend to remain in the natural environment because of the characteristics of hydrophobic compounds that are low in volatility and insoluble in water, and are resistant to acids and bases and environmental degradation process.

In Korea, imports, manufacture and use of PCBs have been banned since 1996, but due to chemical stability, PCBs that had been used previously remain in air, water, and soil, and are still detected as environmental toxicants.

Previous studies have shown that PCBs act as carcinogens and are associated with the onset of breast, stomach, and liver cancer, and are also implicated in atherosclerosis and cardiovascular disease. Exposure to prenatal period may have adverse effects on neural development and development of reproductive organs.

Microarray technology has been used to identify the effects of various chemicals known as environmental hormones on the body. NCBI GEO, ArraryTrack, ArrayExpress and other public microarray databases consistently accumulate quantified and standardized experimental data. In addition, as bioinformatics tools have become more diverse and statistical techniques become more powerful, it has become possible to select differentially expressed genes by integrating different platforms from different studies. Therefore, it is possible to study the effects of certain drugs and environmental hormones on the human body.

Thus, the present inventors have discovered a group of new-use genes that can more accurately determine the exposure of polychlorinated biphenyl 77 by analyzing this common database repository.

Korea Patent No. 10-0537402

It is an object of the present invention to provide a diagnostic kit capable of diagnosing exposure of polychlorinated biphenyl 77 and a method of providing information using the diagnostic kit.

The present invention provides a diagnostic kit that can be used to identify a correlation between liver disease or kidney disease and exposure to polychlorinated biphenyl, and a method of providing information using the same.

1. the nucleotide sequence of the following genes; (Entrez gene ID: 4609), HSP90AB1 (Entrez gene ID: 3326), AARS (Entrez gene ID: 16), LGALS1 (Entrez gene ID (Entrez gene ID: 7393), RPS3 (Entrez gene ID: 6188), HSPA5 (Entrez gene ID: 3309), P4HB (Entrez gene ID: 5034), DNAJA3 (Entrez gene ID: 9093), GPI (Entrez gene ID: 2821), FOXO3 (Entrez gene ID: 2309), BCAP31 (Entrez gene ID: 10134), TNFAIP3 (Entrez gene ID: 7128), NQO1 (Entrez gene ID: 1728), RASA1 5921), DNAJB6 (Entrez gene ID 10049), SIRT1 (Entrez gene ID 23411), LAMTOR5 (Entrez gene ID 10542), PPARG (Entrez gene ID 5468), ASNS (Entrez gene ID 440), BIRC2 Entrez gene ID: 329), HSPD1 (Entrez gene ID: 3329) and SOS1 (Entrez gene ID: 6654).

2. The gene according to item 1 above, wherein the nucleotide sequence of the following gene: (Entrez Gene ID: 2805), RPL24 (Entrez Gene ID: 6152), EPS8 (Entrez Gene ID: 2059), HIF1A (Entrez Gene ID: (Entrez Gene ID: 1394), EIF1 (Entrez Gene ID: 10209), GFPT1 (Entrez Gene ID: 2673), GAPDH (Entrez Gene ID: 2597), GPX4 (Entrez Gene ID: 2879) (Entrez Gene ID: 6337), DNAJB9 (Entrez Gene ID: 4189), EIF2A (Entrez Gene ID: 83939), CSNK1D (Entrez Gene ID: 1453), DNAJB1 (Entrez Gene ID: 3912), MET (Entrez Gene ID: 4233), PPM1B (Entrez Gene ID: 5495), SEC61A1 (Entrez Gene ID: 29927), PFDN5 (Entrez Gene ID: 5204), SRXN1 (Entrez Gene ID: 140809), FAU (Entrez Gene ID: 2197), ABL2 (Entrez Gene ID: 27), ERN1 (Entrez Gene ID: 2081), C10orf2 (Entrez Gene ID: 56652), HYOU1 10525) and ALDOA (Entrez Gene ID: 226).

3. The method according to item 1 above, wherein the nucleotide sequence of the following genes: (Entrez Gene ID: 2805), RPL24 (Entrez Gene ID: 6152), EPS8 (Entrez Gene ID: 2059), HIF1A (Entrez Gene ID: (Entrez Gene ID: 1394), EIF1 (Entrez Gene ID: 10209), GFPT1 (Entrez Gene ID: 2673), GAPDH (Entrez Gene ID: 2597), GPX4 (Entrez Gene ID: 2879) (Entrez Gene ID: 6337), DNAJB9 (Entrez Gene ID: 4189), EIF2A (Entrez Gene ID: 83939), CSNK1D (Entrez Gene ID: 1453), DNAJB1 (Entrez Gene ID: 3912), MET (Entrez Gene ID: 4233), PPM1B (Entrez Gene ID: 5495), SEC61A1 (Entrez Gene ID: 29927), PFDN5 (Entrez Gene ID: 5204), SRXN1 (Entrez Gene ID: 140809), FAU (Entrez Gene ID: 2197), ABL2 (Entrez Gene ID: 27), ERN1 (Entrez Gene ID: 2081), C10orf2 (Entrez Gene ID: 56652), HYOU1 10525) and ALDOA (Entrez Gene ID: 226).

4. The method according to claim 2, wherein the nucleotide sequence of the following gene is selected from the group consisting of: (Entrez Gene ID: 1597), MTHFD2 (Entrez Gene ID: 10797), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: (Entrez Gene ID: 44491), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 1848), DDIT3 (Entrez Gene ID: 1649) (Enterre Gene ID: 54206), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 4499), GARS (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 (Entrez Gene ID: 287234), TRIB3 (Entrez Gene ID: 57761), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502), INHBE (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 (Entrez Gene ID: 51187), MAP1B (Entrez Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 (Entrez Gene ID: 2274), CCNB1IP1 RPL37 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1), RPL7L1 (Entrez Gene ID: 285855) 1951), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X Entrez Gene ID: 8412), RPL9 (Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675), ZSWIM6 ), CD63 (Entrez Gene ID: 967), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG (Entrez Gene ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 (Entrez Gene ID: 6170), SOWAHC (Entrez Gene ID: 65124), NARS , SLC3A2 (Entrez Gene ID 6520), RPL27 (Entrez Gene ID 6155), AMIGO2 (Entrez Gene ID 347902), MAFF (Entrez Gene ID 23764), S100A2 (Entrez Gene ID 6273), MIF ID: 4282), WDR45B (Entrez Gene ID 56270), SERINC1 (Entrez Gene ID 57515), ASAP2 (Entrez Gene ID 8853), SDCBP (Entrez Gene ID 6386), EVA1A (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6123), MAP4K3 (Entrez Gene ID: 8491), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5,159), PRNP (Entrez Gene ID: 5621), RPL29 (Entrez Gene ID: 6159), SELENOS (Entrez Gene ID: Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690), EEF2 (Entrez Gene ID: 1938), MGLL ), ADM (Entrez Gene ID 133), SSR4 (Entrez Gene ID 6748), PLPP2 (Entrez Gene ID 8612), CD55 (Entrez Gene ID 1604), GHITM (Entrez Gene ID 27069), IGFBP3 Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F (Entrez Gene ID: 4494), PSAP (Entrez Gene ID: 5660), SARS 1), NSMCE2 (Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518), EPB41L4A- (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 6146), BAG3 (Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 61535), YPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 1192), CDK7 (Entrez Gene ID: 1022), EIF2S3 1960), WWTR1 (Entrez Gene ID: 25937), GCLM (Entrez Gene ID: 2730), TMEM167B (Entrez Gene ID: 56900), CAPG (Entrez Gene ID: 822), F2RL1 Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 (Entrez Gene ID: 10158), ATG101 (Entrez Gene ID: 60673), TP53BP2 (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 9709), PDGFC (Entrez Gene ID: 56034), SLC7A5 (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 1350), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076) (Entrez Gene ID: 3475), YARS (Entrez Gene ID: 8565), CD46 (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 : Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335), PUS7 (Entrez Gene ID: 54517), NONO (Entrez Gene ID: 4841), EIF5 (Entrez Gene ID: 1983), TATDN1 (Entrez Gene ID: 83940), CSGALNACT2 (Entrez Gene ID: 7122), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: ), OAZ1 (Entrez Gene ID 4946), SLC19A2 (Entrez Gene ID 10560), GNS (Entrez Gene ID 2799), SYPL1 (Entrez Gene ID: 6856), TRAM1 (Entrez Gene ID 23471), NMD3 Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 8887), OXSR1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 306), NIP7 (Entrez Gene ID: 51388), GCLC ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 51719), TIMP1 (Entrez Gene ID: 7076), BNIP3L BMP31 (Entrez Gene ID: 8496), HSPA13 (Entrez Gene ID: 6782), TMBIM6 (Entrez Gene ID: 7009), GTF2H3 (Entrez Gene ID: (Entrez Gene ID: 54677), SEC22B (Entrez Gene ID: 9554), CXorf40B (Entrez Gene ID: 541578), KIAA1033 (Entrez Gene ID: 23325), CDYL Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55353), CDV3 (Entrez Gene ID: 55573), FEM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 10237), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 38348), WDR82 (Entrez Gene ID: 80335), MYOF (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341) (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 (Entrez Gene ID: 7342), CDK8 (Entrez Gene ID: 1024), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 44426), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 (Entrez Gene ID: 90), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441), SMIM20 (Entrez Gene ID: 389203), DSG2 9), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA ), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 84803), AMMECR1L (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 Gene ID: 26156), APP (Entrez Gene ID: 351), RYBP (Entrez Gene ID: 23429), TMEM268 (Entrez Gene ID: 203197), RPL22L1 (Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 51330), GPT2 (Entrez Gene ID: 8757), EFNF3A (Entrez Gene ID: (Entrez Gene ID: 10959), SLC38A1 (Entrez Gene ID: 81539), FNBP1L (Entrez Gene ID: 54874), TNFSF10 (Entrez Gene ID: 9590), CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227) (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN (Entrez Gene ID: 10133), PHF10 : Entrez Gene ID: 54471), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 (Entrez Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 5106), SUCO (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 6324), CXCL16 (Entrez Gene ID: 5323), RNF146 (Entrez Gene ID: 81847), CCL20 Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 100505687), SCYL2 LF5 (Entrez Gene ID: 688), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 (Entrez Gene ID: 10379), SEC24B (Entrez Gene ID: 10427), KLHL23 : Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 (Entrez Gene ID: 10467), SERPINE1 (Entrez Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 (Entrez Gene ID: 51170), FAM110C (Entrez Gene ID: 6999), AKAP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: 1832), MEGF9 (Entrez Gene ID: 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 (Entrez Gene ID: 9975), KRCC1 (Entrez Gene ID: 51315), JMY ), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 (Entrez Gene ID: 8870), RGS2 (Entrez Gene ID: (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 (Entrez Gene ID: 57088), RBM24 (Entrez Gene ID: 221662), HSD11B2 (Entrez Gene ID: 3291), EGR1 Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 (Entrez Gene ID: 643224), NFE2 (Entrez Gene ID: 4778), LRRC45 ), ZNF385C (Entrez Gene ID: 201181), EGR3 (Entrez Gene ID: 1960), UBL7-AS1 (Entrez Gene ID: 440288), OLIG3 (Entrez Gene ID: 167826) (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 (Entrez Gene ID: 5307), CCDC144NL-AS1 Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482), SOX18 (Entrez Gene ID: 54345), DPP10 ), LINC01209 (Entrez Gene ID: 101928684), USP3-AS1 (Entrez Gene ID: 100130855), ZNF852 (Entrez Gene ID: 285346), ZNF417 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), HAO1 (Entrez Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: (Enterre Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755) (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA (Entrez Gene ID: 1409), FAM198B (Entrez Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SULF2 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 84072), TTLL7-IT1 (Entrez Gene ID: 100874314), PRAMEF12 (Entrez Gene ID: 390999), FZD10 (Entrez Gene ID: 11211), B4GALNT4 Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 442524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 643401), CENPK , KDM1B (Entrez Gene ID: 221656), PITPNA-AS1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353) (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 91947), GK3P (Entrez Gene ID: 2713), TXNIP (Entrez Gene ID: 10628), UHRF1 At least one selected from the group consisting of RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9582) and DLGAP5 (Entrez Gene ID: 9787).

5. The method according to item 3 above, wherein the nucleotide sequence of the following genes: (Entrez Gene ID: 1597), MTHFD2 (Entrez Gene ID: 10797), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: (Entrez Gene ID: 44491), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 1848), DDIT3 (Entrez Gene ID: 1649) (Enterre Gene ID: 54206), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 4499), GARS (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 (Entrez Gene ID: 287234), TRIB3 (Entrez Gene ID: 57761), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502), INHBE (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 (Entrez Gene ID: 51187), MAP1B (Entrez Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 (Entrez Gene ID: 2274), CCNB1IP1 RPL37 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1), RPL7L1 (Entrez Gene ID: 285855) 1951), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X Entrez Gene ID: 8412), RPL9 (Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675), ZSWIM6 ), CD63 (Entrez Gene ID: 967), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG (Entrez Gene ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 (Entrez Gene ID: 6170), SOWAHC (Entrez Gene ID: 65124), NARS , SLC3A2 (Entrez Gene ID 6520), RPL27 (Entrez Gene ID 6155), AMIGO2 (Entrez Gene ID 347902), MAFF (Entrez Gene ID 23764), S100A2 (Entrez Gene ID 6273), MIF ID: 4282), WDR45B (Entrez Gene ID 56270), SERINC1 (Entrez Gene ID 57515), ASAP2 (Entrez Gene ID 8853), SDCBP (Entrez Gene ID 6386), EVA1A (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6123), MAP4K3 (Entrez Gene ID: 8491), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5,159), PRNP (Entrez Gene ID: 5621), RPL29 (Entrez Gene ID: 6159), SELENOS (Entrez Gene ID: Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690), EEF2 (Entrez Gene ID: 1938), MGLL ), ADM (Entrez Gene ID 133), SSR4 (Entrez Gene ID 6748), PLPP2 (Entrez Gene ID 8612), CD55 (Entrez Gene ID 1604), GHITM (Entrez Gene ID 27069), IGFBP3 Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F (Entrez Gene ID: 4494), PSAP (Entrez Gene ID: 5660), SARS 1), NSMCE2 (Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518), EPB41L4A- (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 6146), BAG3 (Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 61535), YPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 1192), CDK7 (Entrez Gene ID: 1022), EIF2S3 1960), WWTR1 (Entrez Gene ID: 25937), GCLM (Entrez Gene ID: 2730), TMEM167B (Entrez Gene ID: 56900), CAPG (Entrez Gene ID: 822), F2RL1 Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 (Entrez Gene ID: 10158), ATG101 (Entrez Gene ID: 60673), TP53BP2 (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 9709), PDGFC (Entrez Gene ID: 56034), SLC7A5 (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 1350), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076) (Entrez Gene ID: 3475), YARS (Entrez Gene ID: 8565), CD46 (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 : Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335), PUS7 (Entrez Gene ID: 54517), NONO (Entrez Gene ID: 4841), EIF5 (Entrez Gene ID: 1983), TATDN1 (Entrez Gene ID: 83940), CSGALNACT2 (Entrez Gene ID: 7122), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: ), OAZ1 (Entrez Gene ID 4946), SLC19A2 (Entrez Gene ID 10560), GNS (Entrez Gene ID 2799), SYPL1 (Entrez Gene ID: 6856), TRAM1 (Entrez Gene ID 23471), NMD3 Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 8887), OXSR1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 306), NIP7 (Entrez Gene ID: 51388), GCLC ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 51719), TIMP1 (Entrez Gene ID: 7076), BNIP3L BMP31 (Entrez Gene ID: 8496), HSPA13 (Entrez Gene ID: 6782), TMBIM6 (Entrez Gene ID: 7009), GTF2H3 (Entrez Gene ID: (Entrez Gene ID: 54677), SEC22B (Entrez Gene ID: 9554), CXorf40B (Entrez Gene ID: 541578), KIAA1033 (Entrez Gene ID: 23325), CDYL Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55353), CDV3 (Entrez Gene ID: 55573), FEM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 10237), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 38348), WDR82 (Entrez Gene ID: 80335), MYOF (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341) (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 (Entrez Gene ID: 7342), CDK8 (Entrez Gene ID: 1024), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 44426), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 (Entrez Gene ID: 90), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441), SMIM20 (Entrez Gene ID: 389203), DSG2 9), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA ), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 84803), AMMECR1L (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 Gene ID: 26156), APP (Entrez Gene ID: 351), RYBP (Entrez Gene ID: 23429), TMEM268 (Entrez Gene ID: 203197), RPL22L1 (Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 51330), GPT2 (Entrez Gene ID: 8757), EFNF3A (Entrez Gene ID: (Entrez Gene ID: 10959), SLC38A1 (Entrez Gene ID: 81539), FNBP1L (Entrez Gene ID: 54874), TNFSF10 (Entrez Gene ID: 9590), CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227) (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN (Entrez Gene ID: 10133), PHF10 : Entrez Gene ID: 54471), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 (Entrez Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 5106), SUCO (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 6324), CXCL16 (Entrez Gene ID: 5323), RNF146 (Entrez Gene ID: 81847), CCL20 Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 100505687), SCYL2 LF5 (Entrez Gene ID: 688), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 (Entrez Gene ID: 10379), SEC24B (Entrez Gene ID: 10427), KLHL23 : Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 (Entrez Gene ID: 10467), SERPINE1 (Entrez Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 (Entrez Gene ID: 51170), FAM110C (Entrez Gene ID: 6999), AKAP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: 1832), MEGF9 (Entrez Gene ID: 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 (Entrez Gene ID: 9975), KRCC1 (Entrez Gene ID: 51315), JMY ), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 (Entrez Gene ID: 8870), RGS2 (Entrez Gene ID: (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 (Entrez Gene ID: 57088), RBM24 (Entrez Gene ID: 221662), HSD11B2 (Entrez Gene ID: 3291), EGR1 Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 (Entrez Gene ID: 643224), NFE2 (Entrez Gene ID: 4778), LRRC45 ), ZNF385C (Entrez Gene ID: 201181), EGR3 (Entrez Gene ID: 1960), UBL7-AS1 (Entrez Gene ID: 440288), OLIG3 (Entrez Gene ID: 167826) (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 (Entrez Gene ID: 5307), CCDC144NL-AS1 Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482), SOX18 (Entrez Gene ID: 54345), DPP10 ), LINC01209 (Entrez Gene ID: 101928684), USP3-AS1 (Entrez Gene ID: 100130855), ZNF852 (Entrez Gene ID: 285346), ZNF417 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), HAO1 (Entrez Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: (Enterre Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755) (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA (Entrez Gene ID: 1409), FAM198B (Entrez Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SULF2 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 84072), TTLL7-IT1 (Entrez Gene ID: 100874314), PRAMEF12 (Entrez Gene ID: 390999), FZD10 (Entrez Gene ID: 11211), B4GALNT4 Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 442524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 643401), CENPK , KDM1B (Entrez Gene ID: 221656), PITPNA-AS1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353) (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 91947), GK3P (Entrez Gene ID: 2713), TXNIP (Entrez Gene ID: 10628), UHRF1 : 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9582) and DLGAP5 (Entrez Gene ID: 9787).

6. The diagnostic kit according to any one of 1 to 5 above, wherein the diagnostic kit is a microarray.

7. A method for providing polychlorinated biphenyl 77 exposure information comprising the step of hybridizing any one of the above-described diagnostic kits 1 to 5 with a cDNA of a liver or kidney disease cell line.

8. The method of claim 7, further comprising the step of determining that exposure to polychlorinated biphenyl 77 is increased if expression of the following gene is increased: 77. Method of providing exposure information: CYP1A1 (Entrez Gene ID: 1543), MTHFD2 (Entrez Gene ID: 10797), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: 9792), ZFAS1 (Entrez Gene ID: 441951), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 1848), DDIT3 (Entrez Gene ID: 1649), ERRFI1 (Entrez Gene ID: 54206), GOT1 (Entrez Gene ID: 2805), AGO2 (Entrez Gene ID: 27161), MT1M Entrez Gene ID: 4499), GARS (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 (Entrez Gene ID: 1847), LURAP1L (Entrez Gene ID: 286343), TRIB3 ), SLC25A6 (Entrez Gene ID 293), MT2A (Entrez Gene ID 4502), INHBE (Entrez Gene ID 83729), ATF4 (Entrez Gene ID 468), RSL24D1 (Entrez Gene ID 51187) Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 (Entrez Gene ID: 2274), CCNB1IP1 (Entrez Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285855), RPL37 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1195), PLAU (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 8412), RPL24 ID: 6152), RPL9 (Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675), ZSWIM6 (Entrez Gene ID: 57688) (Entrez Gene ID: 967), EPS8 (Entrez Gene ID: 2059), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG (Entrez Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 (Entrez Gene ID: 6170), SOWAHC (Entrez Gene ID: 4677), SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902), MAFF (Entrez Gene ID: 23764), S100A2 HIF1A (Entrez Gene ID: 3091), WDR45B (Entrez Gene ID: 56270), CRK (Entrez Gene ID: 1398), EIF1 (Entrez Gene ID: 10209) ), SERINC1 (Entrez Gene ID 57515), ASAP2 (Entrez Gene ID 8853), SDCBP (Entrez Gene ID 6386), EVA1A (Entrez Gene ID 84141), MAP4K3 (Entrez Gene ID 8491), INPP1 Gene ID: 3628), AZIN1 (Entrez Gene ID: 51582), SNAPC1 (Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 11260), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 (Entrez Gene ID: 3576), NOP58 ID No. 51602), TMEM69 (Entrez Gene ID: 51249), PRNP (Entrez Gene ID: 5621), RPL29 (Entrez Gene ID: 6159), SELENOS (Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690), GFPT1 (Entrez Gene ID: 2673), EEF2 (Entrez Gene ID: 1938), MGLL (Entrez Gene ID: 11343), GAPDH (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 (Entrez Gene ID: 1604), GHITM ), IGFBP3 (Entrez Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F (Entrez Gene ID: 4494), PSAP Gene ID: 6301), NSMCE2 (Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518), EPB41L4A- (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 6146), BAG3 (Entrez Gene ID: 9531), SELENOK Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 54915), DDX21 (Entrez Gene ID: 9188), MOSPD1 ), HAVCR1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 1192), CDK7 (Entrez Gene ID: 1968), GPX4 (Entrez Gene ID: 2879), WWTR1 (Entrez Gene ID: 25937), GCLM (Entrez Gene ID: 2730), TMEM167B (Entrez Gene ID: 56900), NFKBIZ Entrez Gene ID: 64332), CAPG (Entrez Gene ID: 822), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 ), ATG101 (Entrez Gene ID: 60673), TP53BP2 (Entrez Gene ID: 7159), EIF3D (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 9709) Gene ID: 56034), SLC7A5 (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 1350), DNAJB9 (Entrez Gene ID: 4189), CHMP4C (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), EIF2A (Entrez Gene ID: 83939), YARS ID: 8565), CD46 (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 (Entrez Gene ID: 284996), UPP1 (Entrez Gene ID: 23357), CYR61 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335) , PUS7 (Entrez Gene ID 54517), NONO (Entrez Gene ID 4841), EIF5 (Entrez Gene ID 1983), TATDN1 (Entrez Gene ID 83940), CSGALNACT2 (Entrez Gene ID 55454), ZFAND1 ID: 79752), AMD1 (Entrez Gene ID: 262), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018), OAZ1 (Entrez Gene ID: 10560), GNS (Entrez Gene ID: 2799), CSNK1D (Entrez Gene ID: 1453), SYPL1 (Entrez Gene ID: 6856), TRAM1 (Entrez Gene ID: 23471), DNAJB1 : 3337), NMD3 (Entrez Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 8887), LAMB1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 51389), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEHl (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 51719) (Entrez Gene ID: 7076), BNIP3L (Entrez Gene ID: 665), SH3RF1 (Entrez Gene ID: 57630), BUD31 (Entrez Gene ID: 8896), BEX2 (Entrez Gene ID: 84707), HSPA13 (Entrez Gene ID: 4993), GTF2H3 (Entrez Gene ID: 2967), SEC61A1 (Entrez Gene ID: 29927), PPM1B (Entrez Gene ID: 5495) (Entrez Gene ID: 54977), SEC22B (Entrez Gene ID: 9554), PFDN5 (Entrez Gene ID: 5204), CXorf40B (Entrez Gene ID: 541578), KIAA1033 (Entrez Gene ID: 23325), CDYL (Entrez Gene ID: 55573), CDX3 (Entrez Gene ID: 55573), NAXD (Entrez Gene ID: (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 10237), UBTD2 (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 480809), LINC00493 (Entrez Gene ID: 388789), WDR82 Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341), ATP6V1A (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 ), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 Entrez Gene ID: 2197), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), ABL2 (Entrez Gene ID: 27), CPE (Entrez Gene ID: 1363) (Entrez Gene ID: 90441), SMIM20 (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 (Entrez Gene ID: 5292), EDEM3 (Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 (Entrez Gene ID: 51001), GPAT3 , Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 (Entrez Gene ID: 26156), APP (Entrez Gene ID: 351), RYBP ID No. 23429), TMEM268 (Entrez Gene ID 203197), ERN1 (Entrez Gene ID 2081), RPL22L1 (Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID 5876), EBLN3P (Entrez Gene ID: 100506710) (Entrez Gene ID: 8673), NFE2L1 (Entrez Gene ID: 4779), C10orf2 (Entrez Gene ID: 56652), CXorf40A (Entrez Gene ID: 91966), HYOU1 (Entrez Gene ID: 10525), TNFRSF12A (Entrez Gene ID: 84706), TMED2 (Entrez Gene ID: 10959), SLC38A1 (Entrez Gene ID: 81539), FNBP1L (Entrez Gene ID: 54874), TNFSF10 (Entrez Gene ID: 9590), CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH Entrez Gene ID: 26227), VGF (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN (Entrez Gene ID: 10133), PHF10 ), ZSCAN29 (Entrez Gene ID: 146050), MIEF1 (Entrez Gene ID: 54471), ALDOA (Entrez Gene ID: 226), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 10253), ETFB (Entrez Gene ID: 2109), ACYP2 (Entrez Gene ID: 98), CRIM1 (Entrez Gene ID: 51232), RNF146 ID: 81847), CCL20 (Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 100505687) (Entrez Gene ID: 55681), KLF5 (Entrez Gene ID: 688), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 374), SEC24B (Entrez Gene ID: 10427), KLHL23 (Entrez Gene ID: 151230), LONP1 (Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 Entrez Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 ), FAM110C (Entrez Gene ID: 642273), SETD1B (Entrez Gene ID: 23067), RPP40 (Entrez Gene ID: 10799), AKAP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: 1832), MEGF9 Gene ID: 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 , Entrez Gene ID: 51315), JMY (Entrez Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 (Entrez Gene ID: 8870), RGS2 ID 5997), ND6 (Entrez Gene ID 4541), SLC16A6 (Entrez Gene ID 9120), PLSCR4 (Entrez Gene ID 57088) and RBM24 Rez Gene ID: 221662).

9. The method of claim 7, further comprising the step of determining that exposure to polychlorinated biphenyl 77 if the expression of the following gene is decreased: 77 polyclonal biphenyl 77 Method of providing exposure information: HSD11B2 (Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 (Entrez Gene ID: 643224), NFE2 (Entrez Gene ID: 4778), LRRC45 (Entrez Gene ID: 1960), UBL7-AS1 (Entrez Gene ID: 440288), OLIG3 (Entrez Gene ID: 167826), GAPT (Entrez Gene ID: 202309) (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 (Entrez Gene ID: 5307), CCDC144NL-AS1 (Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482), SOX18 (Entrez Gene ID: 54345), DPP10 57628), LINC01209 (Entrez Gene ID: 1019286 (Entrez Gene ID: 56122), ZNF417 (Entrez Gene ID: 147687), P2RY13 (Entrez Gene ID: 53829), PCDHB14 (Entrez Gene ID: 56122), USP3-AS1 (Entrez Gene ID: 100130855) CD4 (Entrez Gene ID: 924), HAO1 (Entrez Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA ID: 1409), FAM198B (Entrez Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SAC3D1 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 84072), TTLL7- (Entrez Gene ID: 390999), FZD10 (Entrez Gene ID: 11211), B4GALNT4 (Entrez Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 442524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 64105), KDM1B Gene ID: 221656), PITPNA-AS1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353), ATP2A1 (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 2713), TKNIP (Entrez Gene ID: 10628), UHRF1 (Entrez Gene ID: 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B Entrez Gene ID: 9582) and DLGAP5 (Entrez Gene ID: 9787).

The diagnostic kit of the present invention can accurately determine whether polychlorinated biphenyl 77 is exposed.

The diagnostic kit of the present invention can be used for studying the correlation between liver disease or kidney disease and polychlorinated biphenyl 77 exposure.

Figure 1 shows the structure of polychlorinated biphenyls (PCBs), dioxins and polychlorinated biphenyl 77 (PCB77): (A) shows the structure of polychlorinated biphenyls (PCBs) ≪ RTI ID = 0.0 > meta-, < / RTI > a biphenyl group having 12 carbons forming four para-positions; (B) shows the structure of one of the representative dioxins, tetrachlorodibenzodioxin; (C) shows the structure of polychlorinated biphenyl 77 (PCB77) which is coplanar PCB.
Figure 2 shows the correlation between PCB77 and four liver diseases and two kidney diseases and the results of gene ontology enrichment analysis: (A) is a Gene Set Enrichment Analysis (GSEA) Shows that upregulation of DEGs (Differentially expressed genes) for four liver diseases and two kidney diseases is highly concentrated in genes that are upregulated at PCB77 exposure (GEO numbers are shown on the left of each GSEA plot have.); (B) shows the results of GO enrichment analysis using differentially expressed genes (DEGs) up-regulated according to PCB77 exposure, and the color shows a significant level (T2DM, type 2 diabetes mellitus; steatosis, (RCC, renal cancer, NES, normalized concentration score, FDR, false discovery rates).
Figure 3 shows the results of an overall protein-protein interaction (PPI) network analysis of up-regulated DEGs: 124 nodes represent proteins, 249 edges represent interactions, Is represented by a rounded rectangle and the transcription factor is represented by a diamond; The color of the node represents the degree of neighboring network, and the blue frame represents the protein involved in the regulation of the apoptotic process of FIG. 2B.
Figure 4 shows a sub-network using the DEGs included in the five GOs obtained in Figure 2B from the overall protein-protein interaction (PPI) network analysis of Figure 3: 124 nodes, 249 edges represent interactions, the protein is represented by a rounded rectangle, and the transcription factor is represented by a diamond; The color of the node represents the degree of neighboring network, and the blue frame represents the protein involved in the regulation of the apoptotic process of FIG. 2B.

Hereinafter, specific embodiments of the present invention will be described. However, this is merely an example and the present invention is not limited thereto.

The present invention relates to a diagnostic kit comprising a biomarker for the detection of polychlorinated biphenyl 77, comprising: a base sequence of the biomarker; Or its complementary base sequence, it is possible to accurately determine whether the polychlorinated biphenyl 77 is exposed, and to determine whether it can be used to study the correlation between liver disease or kidney disease and polychlorinated biphenyl 77 exposure, And a diagnostic kit comprising a biomarker for polychlorinated biphenyl 77 exposure.

The term "complementary" when used in reference to a nucleic acid means a nucleic acid having a polarity in one direction containing a polynucleotide sequence in which the bases bind to bases of a polynucleotide of another nucleic acid of opposite polarity . For example, a nucleic acid having a sequence GCAT in the 5 'to 3' direction is complementary to a nucleic acid having a sequence CGTA in the 3 'to 5' direction. As used herein, the term complementary is used to include substantially complementary nucleic acids. Substantially complementary means that not all nucleotides are paired with the nucleotides of another nucleic acid, but nevertheless both nucleic acids have a sequence capable of forming a stable hybrid under certain conditions.

"Sequence" means a polymer in which several deoxyribonucleotides or ribonucleotides are polymerized in the form of a single strand or a double strand, and unless otherwise specified, natural or non- (E. G., Phosphorothioate, alkylphosphorothioate or peptide nucleic acids), intercalating agents, and the like.

In the present invention, the term "diagnosis" includes quantitatively and / or qualitatively analyzing the expression of a gene involved in the exposure of polychlorinated biphenyl 77, and the method comprising detecting the presence or absence of the gene, Are well known in the art, and those skilled in the art will be able to select the appropriate method for practicing the invention.

In the present invention, the terms "base sequence of gene" and "complementary base sequence thereof" include not only the base sequence of the whole gene and its complementary base sequence but also the base sequence of a part of the gene and its complementary base sequence, A base sequence of sufficient length to determine whether the expression of the gene is increased or decreased is sufficient. For example, the length may be 15 to 50 bp, but is not limited thereto.

The polychlorinated biphenyl 77 exposure kit of the present invention comprises a nucleotide sequence of the following genes: (Entrez gene ID: 4609), HSP90AB1 (Entrez gene ID: 3326), AARS (Entrez gene ID: 16), LGALS1 (Entrez gene ID: 3956), UBC ID: 7316), RPS3 (Entrez gene ID 6188), HSPA5 (Entrez gene ID 3309), P4HB (Entrez gene ID 5034), DNAJA3 (Entrez gene ID 9093), GPI (Entrez gene ID 2821) (Entrez gene ID: 7128), NQO1 (Entrez gene ID: 1728), RASA1 (Entrez gene ID: 5921), DNAJB6 (Entrez gene ID (Entrez gene ID: 440), BIRC2 (Entrez gene ID: 329), HSPD1 (Entrez gene ID: 5404), SIRT1 (Entrez gene ID: 3329) and SOS1 (Entrez gene ID: 6654).

The 23 genes are genes involved in apoptosis among differentially expressed genes in human liver cancer cell line and human kidney cell line when exposed to polychlorinated biphenyl 77. [ By confirming their expression, it is possible to accurately detect the exposure of polychlorinated biphenyl 77. Therefore, the diagnostic kit of the present invention can accurately determine whether or not the polychlorinated biphenyl 77 is exposed.

The detection of the polychlorinated biphenyl 77 can be accurately determined by the detection of the nucleotide sequence or its complementary base sequence. However, unexpected problems (for example, Or machine mistakes), it is difficult to completely rule out the possibility of doubtfulness of the accuracy of exposure to polychlorinated biphenyls 77.

According to one embodiment of the present invention, the nucleotide sequence of the following genes: (Entrez Gene ID: 1543), MTHFD2 (Entrez Gene ID: 10797), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: 9792), ZFAS1 (Entrez Gene ID: 44491), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 1848), DDIT3 GOT1 (Entrez Gene ID: 2805), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 4499), GARS (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 Entrez Gene ID: 1847), LURAP1L (Entrez Gene ID: 286343), TRIB3 (Entrez Gene ID: 57761), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502), INHBE ), ATF4 (Entrez Gene ID 468), RSL24D1 (Entrez Gene ID 51187), MAP1B (Entrez Gene ID 4131), IARS (Entrez Gene ID 3376), FHL2 (Entrez Gene ID 2274), CCNB1IP1 Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285855), RPL37 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1195), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 6174), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675), ZSWIM6 (Entrez Gene ID: 7327), EPS6 (Entrez Gene ID: 2059), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG ), CTH (Entrez Gene ID 1491), RSRC2 (Entrez Gene ID 65117), CCT2 (Entrez Gene ID 10576), PTTG1IP (Entrez Gene ID 754), RPL39 (Entrez Gene ID 6170), SOWAHC Gene ID: 65124), NARS (Entrez Gene ID: 4677), SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902) HIF1A (Entrez Gene ID: 3091), WDR45B (Entrez Gene ID: 56270), CRK (Entrez Gene ID: 1398), EIF1 (En), S100A2 (Entrez Gene ID: 6273) (Entrez Gene ID: 8453), SDCBP (Entrez Gene ID: 6386), EVA1A (Entrez Gene ID: 84141), MAP4K3 (Entrez Gene ID: 8491) ), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 51582), SNAPC1 (Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6147), TMSB4X Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 (Entrez Gene ID: 51602), TMEM69 (Entrez Gene ID: 51249), PRNP (Entrez Gene ID: 5621), RPL29 (Entrez Gene ID: 6159), SELENOS (Entrez Gene ID: 55829), RPL8 ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690), GFPT1 (Entrez Gene ID: 2673), EEF2 (Entrez Gene ID: 1938), MGLL (Entrez Gene ID: 11343) (Entrez Gene ID: 2597), ADM (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 (Entrez Gene ID: 1604), GHITM ez Gene ID: 27069), IGFBP3 (Entrez Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F ), SARS (Entrez Gene ID: 6301), NSMCE2 (Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518), EPB41L4A-AS1 (Entrez Gene ID: 114915), STC2 (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 9188), MOSPD1 (Entrez Gene ID: 5115), SELENOK (Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 1192), CDK7 ), EIF2S3 (Entrez Gene ID: 1968), GPX4 (Entrez Gene ID: 2879), WWTR1 (Entrez Gene ID: 25937), GCLM (Entrez Gene ID: 2730), TMEM167B (Entrez Gene ID: 64122), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512) (Entrez Gene ID: 6129), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 6129), PEPZK1IP1 (Entrez Gene ID: 10158), ATG101 (Entrez Gene ID: 60673), TP53BP2 : Entrez Gene ID: 56034), SLC7A5 (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 1350), DNAJB9 (Entrez Gene ID: 4189), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), EIF2A (Entrez Gene ID: 8565), CD46 (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 (Entrez Gene ID: 284996), UPP1 Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Gene ID: 2335), PUS7 (Entrez Gene ID 54517), NONO (Entrez Gene ID 4841), EIF5 (Entrez Gene ID 1983), TATDN1 (Entrez Gene ID 83940), CSGALNACT2 ), ZFAND1 (Entrez Gene ID: 79752), AMD1 (Entrez Gene ID: 262), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018), OAZ1 Gene ID: 4946), SLC19A2 (Entrez Gene ID: 10560), GNS (Entrez Gene ID: 2799), CSNK1D (Entrez Gene ID: 1453), SYPL1 (Entrez Gene ID: 6856), TRAM1 (Entrez Gene ID: 3387), NMD3 (Entrez Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 8887), LAMB1 (Entrez Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), RB1CC1 (Entrez Gene ID: (Entrez Gene ID: 306), NIP7 (Entrez Gene ID: 51388), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 57552), CAB39 Gene ID: 51719), TIMP1 (Entrez Gene ID: 7076), BNIP3L (Entrez Gene ID: 665), SH3RF1 (Entrez Gene ID: 57630), BUD31 (Entrez Gene ID: 8896), BEX2 (Entrez Gene ID: 6782), TMBIM6 (Entrez Gene ID: 7009), MET (Entrez Gene ID: 4233), GTF2H3 (Entrez Gene ID: 2967), SEC61A1 (Entrez Gene ID: 29927), PPM1B ID: 5495), SLC25A38 (Entrez Gene ID: 54977), SEC22B (Entrez Gene ID: 9554), PFDN5 (Entrez Gene ID: 5204), CXorf40B (Entrez Gene ID: 541578), KIAA1033 (Entrez Gene ID: 23325) CD4L (Entrez Gene ID: 9425), FAM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 746), IL6R (Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55773), WX81 (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 10237), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 304), SRXN1 (Entrez Gene ID: 140809), LINC00493 (Entrez Gene ID: 388789), WDR82 (Entrez Gene ID: 80335), MYOF (Entrez Gene ID: 7453), UTRP (Entrez Gene ID: 6329), BCAT1 (Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341), ATP6V1A ), CDK8 (Entrez Gene ID: 1024), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 Gene ID: 10892), ACVR1 (Entrez Gene ID: 90), FAU (Entrez Gene ID: 2197), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), ABL2 , CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441), SMIM20 (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 IDEN: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 (Entrez Gene ID: 5292), EDEM3 (Entrez Gene ID: 80267) (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 (Entrez Gene ID: 26156), APP (Entrez Gene ID: 351 ), RYBP (Entrez Gene ID: 23429), TMEM268 (Entrez Gene ID: 203197), ERN1 (Entrez Gene ID: 2081), RPL22L1 (Entrez Gene ID: 200916), RABGGTB Gene ID: 100506710), VAMP8 (Entrez Gene ID: 8673), NFE2L1 (Entrez Gene ID: 4779), C10orf2 (Entrez Gene ID: 56652), CXorf40A (Entrez Gene ID: 91966), HYOU1 , TNFRSF12A (Entrez Gene ID: 51330), GPT2 (Entrez Gene ID: 84706), TMED2 (Entrez Gene ID: 10959), SLC38A1 (Entrez Gene ID: 81539), FNBP1L (Entrez Gene ID: 54874), TNFSF10 (Entrez Gene ID: 9590), CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227) (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN (Entrez Gene ID: 10133), PH (Entrez Gene ID: 55274), ZSCAN29 (Entrez Gene ID: 146050), MIEF1 (Entrez Gene ID: 54471), ALDOA (Entrez Gene ID: 226), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 5106), SUCO (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 10253), ETFB (Entrez Gene ID: 2109), ACYP2 (Entrez Gene ID: 5323), RNF146 (Entrez Gene ID: 81847), CCL20 (Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 Entrez Gene ID: 100505687), SCYL2 (Entrez Gene ID: 55681), KLF5 (Entrez Gene ID: 688), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 ), SEC24B (Entrez Gene ID: 10427), KLHL23 (Entrez Gene ID: 151230), LONP1 (Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 Gene ID: 10467), SERPINE1 (Entrez Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328) (Entrez Gene ID: 51170), FAM110C (Entrez Gene ID: 642273), SETD1B (Entrez Gene ID: 23067), RPP40 (Entrez Gene ID: 10799), AKAP17A (Entrez Gene ID: 8227) ID: 1832), MEGF9 (Entrez Gene ID: 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 9975), KRCC1 (Entrez Gene ID: 51315), JMY (Entrez Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 (Entrez Gene ID 5997), ND6 (Entrez Gene ID 4541), SLC16A6 (Entrez Gene ID 9120), PLSCR4 (Entrez Gene ID 57088), RBM24 (Entrez Gene ID 221662), HSD11B2 (Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 646024), NFE2 (Entrez Gene ID: 4778), LRRC45 (Entrez Gene ID: 201255), ZNF385C (Entrez Gene ID: 201181), EGR3 Gene ID: 440288), OLIG3 (Entrez Gene ID: 167826), GAPT (Entrez Gene ID: 202309), FDXR (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 5907), CCDC144NL-AS1 (Entrez Gene ID: 440416), CCDC69 (Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733) (Entrez Gene ID: 101927482), SOX18 (Entrez Gene ID: 54345), DPP10 (Entrez Gene ID: 57628), LINC01209 (Entrez Gene ID: 101928684), USP3-AS1 (Entrez Gene ID: 100130855), ZNF852 Gene ID: 285346), ZNF417 (Entrez Gene ID: 147687), P2RY13 (Entrez Gene ID: 53829), PCDHB14 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), HAO1 , ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213- Gene ID: 1409), FAM198B (Entrez Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SAC3D1 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 84072), TTLL7- ID No. 100874314), PRAMEF12 (Entrez Gene ID 390999), FZD10 (Entrez Gene ID 11211), B4GALNT4 (Entrez Gene ID 338707), TMEM52 (Entrez Gene ID 339456), DPY19L2P3 (Entrez Gene ID: 442524) (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 64105), KDM1B (Entrez Gene ID: 221656), PITPNA-AS1 (Entrez Gene ID: 100306951), FOS Gene ID 2353), ATP2A1 (Entrez Gene ID 487), TMEM 238 (Entrez Gene ID 388564), ARRDC4 (Entrez Gene ID 91947), GK3P (Entrez Gene ID 2713), TXNIP (Entrez Gene ID 10628) , UHRF1 (Entrez Gene ID: 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBE At least one or all selected from the group consisting of C3B (Entrez Gene ID: 9582) and DLGAP5 (Entrez Gene ID: 9787).

By further including the nucleotide sequence of these genes or a complementary base sequence thereof, it is possible to carry out duplicate inspection for the exposure of polychlorinated biphenyl 77. This makes it possible to prevent the diagnosis accuracy of polychlorinated biphenyl 77 from being lowered due to the occurrence of the above-mentioned problems. Even if it contains at least one gene that can be included in the gene, the diagnostic accuracy of polychlorinated biphenyl 77 exposure can be enhanced through redundant inspection, but the accuracy can be further increased when the gene is completely contained.

A base sequence of the following genes in the gene group; (Entrez Gene ID: 2805), RPL24 (Entrez Gene ID: 6152), EPS8 (Entrez Gene ID: 2059), HIF1A (Entrez Gene ID: 3091), CRK (Entrez Gene ID: 1398), EIF1 (Entrez Gene ID: 10209), GFPT1 (Entrez Gene ID: 2673), GAPDH (Entrez Gene ID: 2597), GPX4 (Entrez Gene ID: 4189), EIF2A (Entrez Gene ID: 83939), CSNK1D (Entrez Gene ID: 1453), DNAJB1 (Entrez Gene ID: 3337), APEX1 (Entrez Gene ID: 328), LAMB1 Entrez Gene ID: 3912), MET (Entrez Gene ID: 4233), PPM1B (Entrez Gene ID: 5495), SEC61A1 (Entrez Gene ID: 29927), PFDN5 (Entrez Gene ID: 5204), SRXN1 ), FAU (Entrez Gene ID: 2197), ABL2 (Entrez Gene ID: 27), ERN1 (Entrez Gene ID: 2081), C10orf2 (Entrez Gene ID: 56652), HYOU1 (Entrez Gene ID: 10525) and ALDOA Gene ID: 226).

According to one embodiment of the present invention, the diagnostic kit of the present invention may be carried out by separately performing a diagnosis using a base sequence of each gene or a complementary base sequence thereof, or a plurality of base sequences may be mixed in one reaction The diagnosis can be performed.

When the diagnostic kit of the present invention is used in a real-time PCR, the probe may further include a probe comprising a base sequence of the above-mentioned gene or a complementary base sequence thereof. It is preferable to prepare each probe so as to be suitable for use of each base sequence. For example, each probe preferably comprises a sequence corresponding to a portion of the DNA fragment amplified by the base sequence to be used with the probe. Each of the probes may have a fluorescent substance bound to the 5 'end and a quencher to the 3' end. According to a more specific embodiment, a fluorescent material that emits a specific wavelength such as red, green, and blue is bound to the 5'-end of each probe, and a black hole quencher (BHQ) is bonded to the 3'- have. In the state where the fluorescent substance and the quencher are bonded to the probe, the quencher absorbs the light emitted by the fluorescent substance, so that the fluorescent signal is not detected. On the other hand, fluorescence signals can be detected when the fluorescent substance bound by the exonuclease activity of the DNA polymerase is isolated during DNA synthesis and extension. During the course of the polymerase chain reaction, these fluorescence signals can be measured in real time and the presence of polychlorinated biphenyl 77 can be diagnosed based on the increased fluorescence signal. The use of such probes can be useful for real-time PCR reactions.

In the diagnostic kit of the present invention, the reverse reaction and the polymerase chain reaction may be separately performed by preparing separate reaction mixtures, and one reaction mixture may be prepared and subjected to one-step RT-PCR ). ≪ / RTI > According to one embodiment of the present invention, the reaction mix of the one-step RT-PCR is a one-step RT-PCR premix including a reverse transcriptase, a polymerase and a buffer, a detection solution containing a base sequence a detection solution, and an RNA template containing the RNA obtained from the specimen.

The diagnostic kit of the present invention may further include an internal control. In the absence of exposure to polychlorinated biphenyl 77, amplification of the above-mentioned gene does not occur. In order to distinguish the case where gene amplification does not occur due to a problem in this case and the polymerase chain reaction itself, An internal control that includes a base sequence that specifically amplifies an exogenous gene that does not exist and the corresponding foreign gene DNA can be used. The amplification of the internal control can be used to confirm the effectiveness of the polymerase chain reaction.

In addition to the above base sequence set, the diagnostic kit of the present invention may further include a polymerase, a reverse transcriptase, a reaction buffer, a polymerase, a dNTP (dATP, dCTP, dGTP and dTTP), a joiner such as Mg ²⁺ and a buffer . The polymerase and the buffer may be contained in separate containers, or the mixture of the polymerases may be contained in one container, the buffer may be contained in a separate container, or both the polymerase and the buffer may be mixed in a container have.

According to one embodiment of the present invention, the diagnostic kit of the present invention may contain a reaction mixture containing the above base sequence, reverse transcriptase, a polymerase and a buffer in a liquid form (for example, a disposable PCR tube) . It can be stored frozen and thawed if necessary. In the case of these diagnostic kits, the convenience of diagnosis and the speed of diagnosis can be increased since a separate mixing process is not required except for the addition of a sample at the time of diagnosis.

The diagnostic kit of the present invention is not limited to a specific form and can be implemented in various forms. According to one embodiment of the present invention, the diagnostic kit may comprise a lyophilized base sequence contained in a container (e.g., a disposable PCR tube, etc.). In the present invention, a plurality of nucleotide sequences may be mixed and contained in a PCR tube, and each nucleotide sequence may be separately contained in each PCR tube.

According to an embodiment of the present invention, the diagnostic kit of the present invention may be a microarray kit.

In the present invention, the microarray uses a nucleotide sequence (including its complementary base sequence) capable of diagnosing exposure to polychlorinated biphenyl 77 as a hybridizable array element and is immobilized on a substrate I will. Preferred substrates may include, for example, membranes, filters, chips, slides, wafers, fibers, magnetic beads or nonmagnetic beads, gels, tubing, plates, polymers, microparticles and capillaries, as suitable rigid or semi-rigid supports have. The above hybridization array elements are arranged and immobilized on the stomach substrate, and such immobilization can be performed by chemical bonding methods or covalent bonding methods such as UV. For example, the hybridization array element may be bonded to a glass surface modified to include an epoxy compound or an aldehyde group, and may also be bound by UV on a polylysine coating surface. In addition, the above hybridization array elements can be bound to the substrate via linkers (e.g., ethylene glycol oligomers and diamines).

On the other hand, when the sample to be applied to the microarray of the present invention is mRNA, it can be labeled and hybridized with the array elements on the microarray. Hybridization conditions may vary, and detection and analysis of hybridization degree may be variously performed depending on the labeled substance.

According to one embodiment of the present invention, the diagnostic kit of the present invention may be a gene chip kit. In the present invention, the gene chip kit comprises a substrate on which a base sequence (cDNA) corresponding to a nucleotide sequence (complementary base sequence thereof) or a fragment thereof capable of diagnosing exposure to polychlorinated biphenyl 77 is attached by a probe, A reagent, a preparation, and an enzyme for producing a fluorescent-labeled probe. In addition, the substrate may contain a cDNA corresponding to the nucleotide sequence of the quantitative control gene or a fragment thereof.

The diagnostic kit of the present invention can be used for the purpose of confirming the cause of liver disease or kidney disease or confirming the relationship between the occurrence of liver disease or kidney disease and polychlorinated biphenyl 77 exposure. The present invention provides a method for providing polychlorinated biphenyl 77 exposure information comprising the step of hybridizing the above-described diagnostic kit with a cDNA of liver or kidney disease cell line.

Liver or kidney disease cell lines may be obtained from tissues such as those diagnosed with liver or kidney disease, animals (e.g., wild animals, livestock, companion animals, etc.), and even those without suspected liver or kidney disease , Animals, and the like. The method of obtaining the cell line can be carried out using various methods known to those skilled in the art.

To obtain the cDNA from the cell line, extraction can be performed by extracting RNA from the cell line obtained above, and the RNA extraction method can be carried out using various methods known to those skilled in the art. The extracted RNA can be stored at minus 70 ° C.

CDNA which is a fragment of the aforementioned gene existing in the cell line can be synthesized by a base sequence capable of amplifying the aforementioned gene and a reverse transcription reaction through the action of a reverse transcriptase. For example, the reverse transcription reaction can be performed at a temperature of 40 ° C to 50 ° C for 20 minutes to 40 minutes.

After the reverse transcription reaction is completed, the reaction product of the reverse transcription reaction can be inactivated by heating the reaction mixture at a temperature of 85 ° C to 95 ° C for 5 minutes to 20 minutes.

The synthesized cDNA can be used as a template to amplify at least a part of the cDNA of the above-mentioned gene through a polymerase chain reaction by the action (hybridization) of the base sequence of the above-mentioned gene or its complementary base sequence .

Amplification reactions of these genes are well known in the art and include, for example, polymerase chain reaction (PCR), reverse transcription polymerase chain reaction (RT-PCR), ligase Chain reaction (LCR), electron mediated amplification (TMA), nucleic acid sequence substrate amplification (NASBA), and the like.

The result of the amplification reaction can be separated by methods such as agarose gel electrophoresis or capillary electrophoresis, and the DNA polymerized by the nucleotide sequence of the used gene or its complementary base sequence By confirming the presence of the gene having the corresponding length, it is possible to diagnose whether or not the polychlorinated biphenyl 77 is exposed.

In the present invention, it is possible to diagnose exposure to polychlorinated biphenyl 77 by confirming whether expression of each gene is increased or decreased. The increase or decrease of the expression can be judged as an increase when the fold change is 1 or a decrease when the fold change is 1 or less, but other methods known in the art may be used.

According to an embodiment of the present invention, the method may further include determining that the polyclonal biphenyl 77 is exposed when the expression of the following genes is increased (i.e., when the fold change value of the gene exceeds 1): (Enterre Gene ID: 1543), MTHFD2 (Entrez Gene ID: 10797), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: 9792), ZFAS1 (Entrez Gene ID: 441951), SLC22A15 (Entrez Gene ID: 54406), DUSP6 (Entrez Gene ID: 1848), DDIT3 (Entrez Gene ID: 1649), ERRFI1 (Entrez Gene ID: 54206), GOT1 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 4499), GARS (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 (ENTREZ Gene ID: 467), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502), INHBE (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 Entrez Gene ID: 51187), MAP1B (Entrez Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 (Entrez Gene ID: 2274), CCNB1IP1 (Entrez Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285855), RPL37 ), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 6174), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675) , EntZ Gene ID: 57688), CD63 (Entrez Gene ID: 967), EPS8 (Entrez Gene ID: 2059), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 (Entrez Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 (Entrez Gene ID: 65124), NARS (Entrez Gene ID: 4677), SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902), MAFF (Entrez Gene ID: 6273), MIF (Entrez Gene ID: 4282), HIF1A (Entrez Gene ID: 3091), WDR45B (Entrez Gene ID: 56270), CRK (Entrez Gene ID: 1398 ), EIF1 (Entrez Gene ID: 10209), SERINC1 (Entrez Gene ID: 57515), ASAP2 (Entrez Gene ID: 8853), SDCBP (Entrez Gene ID: 6386), EVA1A (Entrez Gene ID: 84141), MAP4K3 Gene ID: 8491), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 51582), SNAPC1 (Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 ID No. 3576), NOP58 (Entrez Gene ID 51602), TMEM69 (Entrez Gene ID 51249), PRNP (Entrez Gene ID 5621), RPL29 (Entrez Gene ID 6159), SELENOS (Entrez Gene ID 55829) RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690), GFPT1 (Entrez Gene ID: 2673), EEF2 Entrez Gene ID: 11343), GAPDH (Entrez Gene ID: 2597), ADM (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 ), GHITM (Entrez Gene ID: 27069), IGFBP3 (Entrez Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F (Entrez Gene ID: 6601), NSMCE2 (Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518) (Entrez Gene ID: 6149), STC2 (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 6146), BAG3 Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 ), MOSPD1 (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 2269), Gene (ID: Gene ID: 2792), Gene (ID: Gene ID: (Entrez Gene ID: 56900), NFKBIZ (Entrez Gene ID: 64332), CAPG (Entrez Gene ID: 822), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 6129), EIF3D (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 9709), PDGFC (Entrez Gene ID: 56034), SLC7A5 (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 775), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), EIF2A Entrez Gene ID: 83939), YARS (Entrez Gene ID: 8565), CD46 (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 Gene ID: 284996), UPP1 (Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 , FN1 (Entrez Gene ID 2335), PUS7 (Entrez Gene ID 54517), NONO (Entrez Gene ID 4841), EIF5 (Entrez Gene ID 1983), TATDN1 (Entrez Gene ID 83940), CSGALNACT2 (Entrez Gene ID: 2621), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018) (Entrez Gene ID: 4946), SLC19A2 (Entrez Gene ID: 10560), GNS (Entrez Gene ID: 2799), CSNK1D (Entrez Gene ID: 1453), SYPL1 (Entrez Gene ID: 6856), TRAM1 : Entrez Gene ID: 33371), NMD3 (Entrez Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 8887), LAMB1 (Entrez Gene ID: 3912), OXSR1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 Gene ID: 64207), ANXA3 (Entrez Gene ID: 306), NIP7 (Entrez Gene ID: 51388), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 8876), BEX2 (Entrez Gene ID: 6676), SH3RF1 (Entrez Gene ID: 57630) ID: 84707), HSPA13 (Entrez Gene ID: 6782), TMBIM6 (Entrez Gene ID: 7009), MET (Entrez Gene ID: 4233), GTF2H3 (Entrez Gene ID: 2967), SEC61A1 (Entrez Gene ID 5495), SLC25A38 (Entrez Gene ID 54977), SEC22B (Entrez Gene ID: 9554), PFDN5 (Entrez Gene ID: 5204), CXorf40B (Entrez Gene ID: 541578), KIAA1033 : Entrez Gene ID: 9425), FAM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 746), IL6R (Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55353), CDV3 (Entrez Gene ID: 55573), NAXD (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 304), SRXN1 (Entrez Gene ID: 140809), LINC00493 (Entrez Gene ID: 388789), WDR82 (Entrez Gene ID: 80335) (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341), ATP6V1A (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 (Entrez Gene ID: 1024), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 (Entrez Gene ID: 90), FAU (Entrez Gene ID: 2197), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), ABL2 (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441), SMIM20 (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 (Entrez Gene ID: 5292), EDEM3 (Gene ID: 84246), VEZF1 (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 ), GPAT3 (Entrez Gene ID: 84803), AMMECR1L (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 (Entrez Gene ID: 26156) Gene ID: 351), RYBP (Entrez Gene ID: 23429), TMEM268 (Entrez Gene ID: 203197), ERN1 (Entrez Gene ID: 2081), RPL22L1 (Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 91966), HYOU1 (Entrez Gene ID: 5679), EFLN3P (Entrez Gene ID: 100506710), VAMP8 (Entrez Gene ID: 8673), NFE2L1 (Entrez Gene ID: 4779), C10orf2 ID No. 10525), TNFRSF12A (Entrez Gene ID 51330), GPT2 (Entrez Gene ID 84706), TMED2 (Entrez Gene ID 10959), SLC38A1 (Entrez Gene ID 81539), FNBP1L (Entrez Gene ID 54874) (Entrez Gene ID: 8743), AKAP12 (Entrez Gene ID: 9590), CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227), VGF (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 5607), ZSCAN29 (Entrez Gene ID: 146050), MIEF1 (Entrez Gene ID: 54471), ALDOA (Entrez Gene ID: 226), MXI1 (Entrez Gene ID: 4601), S100A10 Entrez Gene ID: 6281), FBXO25 (Entrez Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 ), PCK2 (Entrez Gene ID 5106), SUCO (Entrez Gene ID 51430), SPRY2 (Entrez Gene ID 10253), ETFB (Entrez Gene ID 2109), ACYP2 (Entrez Gene ID 98), CRIM1 Gene ID: 51232), RNF146 (Entrez Gene ID: 81847), CCL20 (Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 55681), KLF5 (Entrez Gene ID: 688), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 100505687), SCYL2 (Entrez Gene ID: 10344), SEC24B (Entrez Gene ID: 10427), KLHL23 (Entrez Gene ID: 151230), LONP1 (Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 Entrez Gene ID: 10467), SERPINE1 (Entrez Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 ), HSD17B11 (Entrez Gene ID: 51170), FAM110C (Entrez Gene ID: 642273), SETD1B (Entrez Gene ID: 23067), RPP40 (Entrez Gene ID: 10799), AKAP17A (Entrez Gene ID: 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703) , Ent1z Gene ID: 9975), KRCC1 (Entrez Gene ID: 51315), JMY (Entrez Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 ID: 8870), RGS2 (Entrez Gene ID: 5997), ND6 (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 ez Gene ID: 57088) and RBM24 (Entrez Gene ID: 221662).

According to an embodiment of the present invention, it may further comprise determining that the expression of the following gene is decreased (i.e., when the gene fold change value is less than 1): polyclonal biphenyl 77: HSD11B2 Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 (Entrez Gene ID: 643224), NFE2 ), LRRC45 (Entrez Gene ID: 201255), ZNF385C (Entrez Gene ID: 201181), EGR3 (Entrez Gene ID: 1960), UBL7-AS1 (Entrez Gene ID: 440288) (Entrez Gene ID: 202309), FDXR (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 (Entrez Gene ID: 5307), CCDC144NL-AS1 Entrez Gene ID: 440416), CCDC69 (Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482), SOX18 ), DPP10 (Entrez Gene ID: 57628), LINC0 (Entrez Gene ID: 53829), PCDHB14 (Entrez Gene ID: 101928684), USP3-AS1 (Entrez Gene ID: 100130855), ZNF852 (Entrez Gene ID: 285346), ZNF417 Gene ID: 56122), CD7 (Entrez Gene ID: 924), HAO1 (Entrez Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458) ), CRYAA (Entrez Gene ID: 1409), FAM198B (Entrez Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SAC3D1 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 100874314), PRAMEF12 (Entrez Gene ID: 390999), FZD10 (Entrez Gene ID: 11211), B4GALNT4 (Entrez Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 ID: 442524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 223656), PITPNA-AS1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353), ATP2A1 (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: (Entrez Gene ID: 93547), GK3P (Entrez Gene ID: 2713), TXNIP (Entrez Gene ID: 10628), UHRF1 (Entrez Gene ID: 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9582), and DLGAP5 (Entrez Gene ID: 9787).

By determining whether the expression of the genes is increased or decreased, accurate diagnosis of polychlorinated biphenyl 77 is possible.

It is to be understood that both the foregoing general description and the following detailed description of the present invention are exemplary and explanatory and are intended to be illustrative of the invention and are not intended to limit the scope of the claims. It will be apparent to those skilled in the art that such variations and modifications are within the scope of the appended claims.

Example

Example 1. Data collection to identify genes associated with PCB exposure

Data for meta-analysis were obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database to identify genes associated with PCB exposure. The data is Affymetrix microarray data associated with coplanar PCB77. Since dioxin compounds such as coplanar PCBs have been found to have different toxicological responses among different species, coplanar PCBs-treated data sets have been obtained in human cells from the NCBI GEO database.

Finally, data to be used for meta-analysis are data sets in which human liver cancer HepG2 cells (GSE6869) and human kidney cell HK2 cells (GSE23493) are treated with PCB77. The total number of control groups was 6 and the number of PCB77 treatment groups was 12. Data for 30 minutes of PCB77 treatment were excluded because it turned out that gene expression results did not change significantly.

Example 2. Data pre-processing and batch effect adjustment

The data set of each microarray GSE (GEO series) was preprocessed using the R language oligo package and standardized by a robust multi-array average (RMA) algorithm. Since Entrez ID is a universally used identifier in many bioinformatics analyzes, all Affymetrix microarray annotation packages hgu133plus2.db were used to convert all microarray probe names to unique Entrez IDs. When multiple values were obtained for a single Entrez ID, the average of the values was used as the gene expression value. A total of 20,514 genes were used for the two data sets.

Adjustments were made for nonbiological placement effects. A surrogate variable analysis (SVA) package was used to eliminate the batching effect, which is an abiotic change that occurs when merging multiple studies performed in different environments. The ComBat method, which independently adjusts the level of each gene expression within the package, was used to eliminate the placement effect.

Example 3. Analysis of differential expression gene (DEG) using rank product (RP)

R package RankProd was used to find Differentially expressed genes (DEGs) in meta-analysis. Based on the grade change (FC, Fold change) of each gene, the RP value was calculated by the RP function of the RankProd R package. Using this RP value, DEG was selected from a list of two genes that were up-regulated by default 100 permutation tests.

The ComBat method was applied to the integrated data set to adjust the placement effect, and DEG was selected using the RP (Rank Product) meta-analysis method. The minimum FC was 1.2 and the p-value cut-off was 0.01. A total of 441 genes were identified as DEG. 375 genes were up-regulated and 66 genes were down-regulated under PCB77 treatment (Table 1).

Gene ID Gene Symbol Fold Change P-value Regulation 1543 CYP1A1 4.25 1.7.E-09 up 10797 MTHFD2 2.80 2.1.E-05 up 1051 CEBPB 2.71 2.6.E-06 up 9792 SERTAD2 2.70 4.7.E-06 up 441951 ZFAS1 2.68 4.3.E-06 up 55356 SLC22A15 2.63 1.2.E-06 up 54407 SLC38A2 2.61 2.4.E-05 up 1848 DUSP6 2.52 1.9.E-05 up 1649 DDIT3 2.47 1.4.E-05 up 54206 ERRFI1 2.44 2.5.E-05 up 2805 GOT1 2.41 1.3.E-04 up 27161 AGO2 2.41 3.4.E-05 up 4609 MYC 2.37 5.9.E-05 up 4499 MT1M 2.36 6.9.E-04 up 2617 GARS 2.34 2.5.E-05 up 54541 DDIT4 2.33 3.4.E-05 up 1847 DUSP5 2.33 5.0.E-05 up 286343 LURAP1L 2.31 8.3.E-06 up 57761 TRIB3 2.29 9.0.E-05 up 293 SLC25A6 2.29 4.7.E-04 up 4502 MT2A 2.29 2.3.E-04 up 83729 INHBE 2.28 5.1.E-06 up 468 ATF4 2.28 1.7.E-04 up 51187 RSL24D1 2.27 5.3.E-04 up 4131 MAP1B 2.24 1.1.E-04 up 3376 IARS 2.24 3.6.E-04 up 2274 FHL2 2.23 3.2.E-04 up 57820 CCNB1IP1 2.23 5.9.E-05 up 285855 RPL7L1 2.23 2.5.E-04 up 6167 RPL37 2.22 1.8.E-03 up 1195 CLK1 2.21 9.8.E-05 up 5328 PLAU 2.21 9.8.E-04 up 9168 TMSB10 2.19 1.8.E-04 up 81631 MAP1LC3B 2.19 1.1.E-04 up 1917 EEF1A2 2.18 3.5.E-03 up 4501 MT1X 2.18 8.3.E-04 up 8412 BCAR3 2.17 4.4.E-04 up 6152 RPL24 2.16 2.6.E-03 up 6133 RPL9 2.15 2.5.E-03 up 51251 NT5C3A 2.13 1.1.E-03 up 3074 HEXB 2.13 4.9.E-04 up 3326 HSP90AB1 2.12 7.8.E-04 up 3675 ITGA3 2.12 7.9.E-04 up 57688 ZSWIM6 2.11 9.4.E-04 up 967 CD63 2.11 3.1.E-03 up 2059 EPS8 2.11 4.2.E-04 up 10397 NDRG1 2.10 6.7.E-04 up 7873 MANF 2.10 1.8.E-04 up 7532 YWHAG 2.10 3.0.E-03 up 16 AARS 2.09 5.5.E-04 up 1491 CTH 2.09 2.1.E-04 up 65117 RSRC2 2.09 5.8.E-04 up 10576 CCT2 2.09 2.4.E-03 up 754 PTTG1IP 2.08 1.0.E-03 up 6170 RPL39 2.08 4.4.E-03 up 65124 SOWAHC 2.08 6.8.E-05 up 3956 LGALS1 2.08 7.0.E-04 up 4677 NARS 2.07 1.9.E-03 up 6520 SLC3A2 2.07 1.2.E-03 up 6155 RPL27 2.07 6.5.E-03 up 7316 UBC 2.06 2.5.E-03 up 347902 AMIGO2 2.06 5.6.E-03 up 23764 MAFF 2.06 9.9.E-05 up 6273 S100A2 2.05 1.3.E-03 up 4282 MIF 2.05 9.2.E-04 up 3091 HIF1A 2.04 3.6.E-03 up 56270 WDR45B 2.03 2.6.E-03 up 1398 CRK 2.03 5.4.E-04 up 10209 EIF1 2.03 5.6.E-04 up 57515 SERINC1 2.03 1.4.E-03 up 8853 ASAP2 2.03 5.9.E-04 up 6386 SDCBP 2.03 8.7.E-03 up 84141 EVA1A 2.02 1.6.E-03 up 8491 MAP4K3 2.02 4.2.E-03 up 3628 INPP1 2.02 6.1.E-04 up 51582 AZIN1 2.02 1.3.E-03 up 6617 SNAPC1 2.01 3.7.E-04 up 6303 SAT1 2.01 1.4.E-03 up 6147 RPL23A 2.01 7.9.E-03 up 7114 TMSB4X 2.01 5.6.E-04 up 11260 XPOT 2.01 6.1.E-04 up 5937 RBMS1 2.01 3.4.E-03 up 5209 PFKFB3 2.00 7.5.E-05 up 9804 TOMM20 2.00 2.6.E-03 up 3576 CXCL8 2.00 3.5.E-04 up 51602 NOP58 2.00 1.8.E-03 up 51249 TMEM69 2.00 3.5.E-04 up 5621 PRNP 2.00 5.9.E-04 up 6159 RPL29 2.00 1.4.E-03 up 55829 SELENOS 2.00 6.9.E-04 up 6132 RPL8 1.99 2.2.E-03 up 6902 TBCA 1.99 7.4.E-03 up 51690 LSM7 1.99 9.6.E-04 up 2673 GFPT1 1.99 1.8.E-03 up 1938 EEF2 1.99 2.2.E-03 up 11343 MGLL 1.99 5.5.E-03 up 2597 GAPDH 1.99 8.5.E-03 up 133 ADM 1.98 1.7.E-04 up 6748 SSR4 1.98 3.3.E-03 up 8612 PLPP2 1.98 1.2.E-03 up 1604 CD55 1.97 2.6.E-04 up 27069 GHITM 1.97 3.3.E-03 up 3486 IGFBP3 1.97 2.2.E-04 up 57583 TMEM181 1.96 1.2.E-03 up 9180 OSMR 1.95 8.8.E-04 up 4494 MT1F 1.95 9.9.E-04 up 5660 PSAP 1.95 2.0.E-03 up 6301 SARS 1.95 9.1.E-04 up 6188 RPS3 1.95 5.6.E-03 up 286053 NSMCE2 1.94 2.4.E-03 up 3309 HSPA5 1.94 1.6.E-04 up 56954 NIT2 1.94 3.3.E-03 up 9698 PUM1 1.93 2.5.E-03 up 152518 NFXL1 1.93 7.0.E-04 up 114915 EPB41L4A-AS1 1.93 2.0.E-03 up 8614 STC2 1.93 2.4.E-04 up 50640 PNPLA8 1.93 7.5.E-04 up 6192 RPS4Y1 1.93 4.5.E-03 up 6146 RPL22 1.92 5.4.E-03 up 9531 BAG3 1.92 1.9.E-03 up 58515 SELENOK 1.92 1.0.E-03 up 23645 PPP1R15A 1.92 3.5.E-03 up 6135 RPL11 1.92 9.1.E-03 up 54915 YTHDF1 1.92 2.9.E-03 up 9188 DDX21 1.92 5.7.E-03 up 56180 MOSPD1 1.91 1.9.E-03 up 26762 HAVCR1 1.91 3.7.E-03 up 50854 C6orf48 1.91 7.6.E-04 up 6472 SHMT2 1.90 3.9.E-04 up 1192 CLIC1 1.89 8.3.E-03 up 1022 CDK7 1.89 9.8.E-04 up 1968 EIF2S3 1.89 2.0.E-03 up 2879 GPX4 1.89 3.9.E-03 up 25937 WWTR1 1.89 4.2.E-03 up 2730 GCLM 1.88 6.0.E-04 up 56900 TMEM167B 1.88 1.6.E-03 up 64332 NFKBIZ 1.88 3.5.E-03 up 822 CAPG 1.88 3.4.E-03 up 2150 F2RL1 1.88 3.4.E-04 up 4496 MT1H 1.87 3.6.E-03 up 54700 RRN3 1.87 4.8.E-03 up 4512 COX1 1.87 7.7.E-03 up 10158 PDZK1IP1 1.87 1.3.E-03 up 60673 ATG101 1.87 1.8.E-03 up 7159 TP53BP2 1.87 2.5.E-03 up 8664 EIF3D 1.87 6.5.E-03 up 6229 RPS24 1.86 7.5.E-03 up 9709 HERPUD1 1.86 1.6.E-03 up 56034 PDGFC 1.86 4.9.E-03 up 8140 SLC7A5 1.86 5.2.E-03 up 84154 RPF2 1.86 3.0.E-03 up 1350 COX7C 1.86 3.8.E-03 up 4189 DNAJB9 1.86 1.8.E-03 up 92421 CHMP4C 1.86 9.8.E-04 up 5730 PTGDS 1.85 3.1.E-03 up 718 C3 1.84 6.6.E-03 up 9076 CLDN1 1.84 4.3.E-03 up 3475 IFRD1 1.83 7.0.E-04 up 83939 EIF2A 1.83 2.4.E-03 up 8565 YARS 1.83 1.3.E-03 up 4179 CD46 1.83 1.5.E-03 up 10285 SMNDC1 1.83 3.1.E-03 up 7165 TPD52L2 1.83 2.8.E-03 up 284996 RNF149 1.83 2.8.E-03 up 7378 UPP1 1.83 5.0.E-03 up 23657 SLC7A11 1.82 1.3.E-04 up 5034 P4HB 1.82 4.6.E-03 up 3491 CYR61 1. \ 82 6.1.E-04 up 64859 NABP1 1.82 7.0.E-03 up 1316 KLF6 1.81 7.8.E-03 up 2335 FN1 1.81 9.9.E-03 up 54517 PUS7 1.81 6.6.E-03 up 4841 NONO 1.81 9.1.E-03 up 9093 DNAJA3 1.81 3.0.E-03 up 1983 EIF5 1.81 3.3.E-03 up 83940 TATDN1 1.81 4.9.E-03 up 55454 CSGALNACT2 1.81 9.9.E-04 up 79752 ZFAND1 1.81 2.0.E-03 up 262 AMD1 1.81 2.1.E-03 up 2195 FAT1 1.81 2.2.E-03 up 8721 EDF1 1.80 6.0.E-03 up 5018 OXA1L 1.80 6.8.E-03 up 4946 OAZ1 1.80 9.1.E-03 up 10560 SLC19A2 1.80 5.6.E-04 up 2799 GNS 1.80 5.7.E-03 up 1453 CSNK1D 1.79 4.2.E-03 up 6856 SYPL1 1.79 3.9.E-03 up 23471 TRAM1 1.79 5.3.E-03 up 3337 DNAJB1 1.79 1.2.E-03 up 51068 NMD3 1.79 4.8.E-03 up 328 APEX1 1.79 6.8.E-03 up 5479 PPIB 1.79 1.5.E-03 up 8887 TAX1BP1 1.78 7.1.E-03 up 3912 LAMB1 1.78 5.6.E-03 up 9943 OXSR1 1.78 6.2.E-03 up 9821 RB1CC1 1.78 2.6.E-03 up 4493 MT1E 1.78 4.3.E-03 up 3612 IMPA1 1.78 7.2.E-03 up 64207 IRF2BPL 1.78 1.9.E-03 up 306 ANXA3 1.78 1.3.E-03 up 51388 NIP7 1.78 3.4.E-03 up 2729 GCLC 1.78 1.0.E-03 up 1345 COX6C 1.77 1.0.E-02 up 57552 NCEH1 1.77 2.6.E-03 up 51719 CAB39 1.77 3.7.E-03 up 7076 TIMP1 1.77 3.4.E-03 up 665 BNIP3L 1.77 5.7.E-03 up 57630 SH3RF1 1.77 2.2.E-03 up 8896 BUD31 1.76 4.1.E-03 up 84707 BEX2 1.76 2.4.E-03 up 6782 HSPA13 1.76 1.4.E-03 up 2821 GPI 1.76 6.1.E-03 up 7009 TMBIM6 1.76 9.0.E-03 up 4233 MET 1.76 2.6.E-03 up 2967 GTF2H3 1.76 3.6.E-03 up 2309 FOXO3 1.76 2.4.E-03 up 29927 SEC61A1 1.76 2.8.E-03 up 5495 PPM1B 1.76 5.0.E-03 up 54977 SLC25A38 1.75 4.6.E-03 up 9554 SEC22B 1.75 2.6.E-03 up 5204 PFDN5 1.75 4.3.E-03 up 541578 CXorf40B 1.74 8.5.E-03 up 23325 KIAA1033 1.74 4.5.E-03 up 9425 CDYL 1.74 4.7.E-03 up 221061 FAM171A1 1.74 3.3.E-04 up 746 TMEM258 1.74 6.9.E-03 up 3570 IL6R 1.74 2.5.E-03 up 55353 LAPTM4B 1.74 8.0.E-03 up 55573 CDV3 1.74 7.8.E-03 up 55739 NAXD 1.73 6.0.E-03 up 55884 WSB2 1.73 1.6.E-03 up 51398 WDR83OS 1.73 7.5.E-03 up 10237 SLC35B1 1.73 9.9.E-03 up 92181 UBTD2 1.73 8.6.E-03 up 304 ANXA2P2 1.73 7.0.E-03 up 140809 SRXN1 1.73 3.9.E-03 up 388789 LINC00493 1.73 6.4.E-03 up 80335 WDR82 1.72 9.1.E-03 up 26509 MYOF 1.72 5.8.E-03 up 586 BCAT1 1.72 1.7.E-03 up 9341 VAMP3 1.72 3.0.E-03 up 523 ATP6V1A 1.72 8.0.E-03 up 7453 WARS 1.72 4.2.E-03 up 10134 BCAP31 1.72 7.4.E-03 up 7342 UBP1 1.72 7.7.E-03 up 1024 CDK8 1.72 3.7.E-03 up 116068 LYSMD3 1.72 3.2.E-03 up 10672 GNA13 1.72 5.0.E-03 up 440026 TMEM41B 1.72 5.6.E-03 up 7128 TNFAIP3 1.72 8.2.E-03 up 9919 SEC16A 1.72 7.1.E-03 up 10892 MALT1 1.71 7.5.E-03 up 90 ACVR1 1.71 1.5.E-03 up 2197 FAU 1.71 5.9.E-03 up 51429 SNX9 1.71 8.7.E-03 up 8323 FZD6 1.71 3.6.E-03 up 27 ABL2 1.71 5.5.E-03 up 1363 CPE 1.70 5.6.E-03 up 90441 ZNF622 1.70 6.3.E-03 up 1728 NQO1 1.70 3.4.E-03 up 389203 SMIM20 1.70 4.5.E-03 up 1829 DSG2 1.70 2.0.E-03 up 84549 MAK16 1.70 4.6.E-03 up 55005 RMND1 1.69 4.8.E-03 up 27338 UBE2S 1.69 4.7.E-03 up 5921 RASA1 1.69 9.2.E-03 up 51141 INSIG2 1.69 2.2.E-03 up 5292 PIM1 1.69 1.5.E-03 up 80267 EDEM3 1.68 6.9.E-03 up 84246 MED10 1.68 8.2.E-03 up 7716 VEZF1 1.68 3.8.E-03 up 22856 CHSY1 1.68 3.9.E-03 up 466 ATF1 1.68 5.8.E-03 up 5898 RALA 1.68 6.0.E-03 up 51001 MTERF3 1.68 6.5.E-03 up 84803 GPAT3 1.68 5.5.E-04 up 83607 AMMECR1L 1.68 1.9.E-03 up 84124 ZNF394 1.68 3.2.E-03 up 11137 PWP1 1.67 7.8.E-03 up 26156 RSL1D1 1.67 3.8.E-03 up 351 APP 1.67 4.0.E-03 up 23429 RYBP 1.67 5.9.E-03 up 203197 TMEM268 1.67 1.8.E-03 up 2081 ERN1 1.67 4.9.E-03 up 200916 RPL22L1 1.66 8.9.E-03 up 5876 RABGGTB 1.66 2.9.E-03 up 100506710 EBLN3P 1.66 5.5.E-03 up 8673 VAMP8 1.66 4.3.E-03 up 10049 DNAJB6 1.66 7.5.E-03 up 4779 NFE2L1 1.66 7.9.E-03 up 56652 C10F2 1.66 9.4.E-03 up 91966 CXorf40A 1.66 7.4.E-03 up 10525 HYOU1 1.65 5.5.E-03 up 51330 TNFRSF12A 1.65 8.1.E-03 up 84706 GPT2 1.65 3.6.E-03 up 10959 TMED2 1.65 5.9.E-03 up 81539 SLC38A1 1.65 6.2.E-03 up 54874 FNBP1L 1.65 5.3.E-03 up 8743 TNFSF10 1.65 6.2.E-03 up 9590 AKAP12 1.65 5.7.E-03 up 1054 CEBPG 1.64 6.7.E-03 up 112483 SAT2 1.64 7.1.E-03 up 171586 ABHD3 1.64 9.3.E-03 up 26227 PHGDH 1.64 8.6.E-03 up 7425 VGF 1.64 8.8.E-03 up 25938 HEATR5A 1.64 4.8.E-03 up 51575 ESF1 1.64 5.7.E-03 up 10133 OPTN 1.64 8.6.E-03 up 55274 PHF10 1.64 9.3.E-03 up 146050 ZSCAN29 1.63 3.4.E-03 up 54471 MIEF1 1.63 8.8.E-03 up 226 ALDOA 1.63 6.4.E-03 up 4601 MXI1 1.63 3.4.E-03 up 6281 S100A10 1.63 9.7.E-03 up 23411 SIRT1 1.63 3.4.E-03 up 26260 FBXO25 1.63 7.9.E-03 up 27347 STK39 1.62 9.4.E-03 up 26994 RNF11 1.62 8.9.E-03 up 8602 NOP14 1.62 7.3.E-03 up 10413 YAP1 1.62 7.5.E-03 up 10542 LAMTOR5 1.62 9.4.E-03 up 5106 PCK2 1.61 4.0.E-03 up 51430 SUCO 1.61 5.5.E-03 up 10253 SPRY2 1.61 6.1.E-03 up 2109 ETFB 1.61 4.5.E-03 up 98 ACYP2 1.60 1.0.E-02 up 51232 CRIM1 1.60 5.1.E-03 up 81847 RNF146 1.60 9.6.E-03 up 6364 CCL20 1.60 3.1.E-03 up 58191 CXCL16 1.60 7.7.E-03 up 9069 CLDN12 1.59 4.1.E-03 up 5476 CTSA 1.59 8.8.E-03 up 100505687 LINC00888 1.59 2.6.E-03 up 55681 SCYL2 1.59 6.5.E-03 up 688 KLF5 1.59 7.2.E-03 up 5468 PPARG 1.59 6.6.E-03 up 1027 CDKN1B 1.59 4.7.E-03 up 26122 EPC2 1.58 9.6.E-03 up 440 ASNS 1.58 2.3.E-03 up 10379 IRF9 1.58 2.8.E-03 up 10427 SEC24B 1.58 4.6.E-03 up 151230 KLHL23 1.57 5.4.E-03 up 9361 LONP1 1.57 9.0.E-03 up 11044 PAPD7 1.57 8.2.E-03 up 329 BIRC2 1.57 6.1.E-03 up 10467 ZNHIT1 1.57 9.3.E-03 up 5054 SERPINE1 1.56 6.8.E-03 up 55629 PNRC2 1.56 9.1.E-03 up 100506498 LOC100506498 1.56 9.2.E-03 up 54910 SEMA4C 1.55 9.0.E-03 up 23328 SASH1 1.55 5.3.E-03 up 51170 HSD17B11 1.54 3.4.E-03 up 3329 HSPD1 1.54 9.6.E-03 up 642273 FAM110C 1.53 8.8.E-04 up 23067 SETD1B 1.53 8.8.E-03 up 10799 RPP40 1.53 9.4.E-03 up 8227 AKAP17A 1.53 8.8.E-03 up 1832 DSP 1.53 1.0.E-02 up 1955 MEGF9 1.53 7.4.E-03 up 6091 ROBO1 1.52 3.0.E-03 up 84933 C8orf76 1.52 9.2.E-03 up 2887 GRB10 1.51 7.1.E-03 up 6654 SOS1 1.50 3.0.E-03 up 149703 LOC149703 1.49 8.9.E-03 up 9975 NR1D2 1.49 8.3.E-03 up 51315 KRCC1 1.49 5.9.E-03 up 133746 JMY 1.48 1.7.E-03 up 157285 SGK223 1.46 3.1.E-03 up 10486 CAP2 1.45 8.3.E-03 up 8870 IER3 1.45 4.4.E-03 up 5997 RGS2 1.44 5.8.E-03 up 4541 ND6 1.43 1.3.E-03 up 9120 SLC16A6 1.32 7.7.E-03 up 57088 PLSCR4 1.31 8.6.E-03 up 221662 RBM24 1.27 5.6.E-04 up 3291 HSD11B2 -1.90 2.3.E-04 down 1958 EGR1 -1.81 1.3.E-05 down 64577 ALDH8A1 -1.81 3.6.E-03 down 83539 CHST9 -1.75 6.6.E-04 down 643224 TUBBP5 -1.72 1.4.E-03 down 4778 NFE2 -1.69 2.8.E-03 down 201255 LRRC45 -1.67 1.4.E-03 down 201181 ZNF385C -1.67 1.6.E-03 down 1960 EGR3 -1.66 3.7.E-03 down 440288 UBL7-AS1 -1.65 2.7.E-03 down 167826 OLIG3 -1.65 2.9.E-03 down 202309 GAPT -1.61 2.9.E-03 down 2232 FDXR -1.61 2.7.E-03 down 100506769 C10orf71-AS1 -1.60 9.3.E-04 down 2882 GPX7 -1.60 3.2.E-03 down 5307 PITX1 -1.58 6.5.E-03 down 440416 CCDC144NL-AS1 -1.58 5.7.E-03 down 26112 CCDC69 -1.57 4.9.E-03 down 29951 PDZRN4 -1.57 4.5.E-03 down 79733 E2F8 -1.57 3.3.E-03 down 101927482 LOC101927482 -1.57 4.3.E-03 down 54345 SOX18 -1.57 3.9.E-03 down 57628 DPP10 -1.56 6.1.E-03 down 101928684 LINC01209 -1.56 4.2.E-03 down 100130855 USP3-AS1 -1.54 5.3.E-03 down 285346 ZNF852 -1.54 8.9.E-03 down 147687 ZNF417 -1.53 8.2.E-03 down 53829 P2RY13 -1.53 9.3.E-03 down 56122 PCDHB14 -1.53 7.7.E-03 down 924 CD7 -1.53 6.1.E-03 down 54363 HAO1 -1.52 9.2.E-03 down 286103 ZNF252P-AS1 -1.52 4.8.E-03 down 100506840 IQCF4 -1.52 8.5.E-03 down 402415 XKRX -1.52 7.0.E-03 down 50613 UBQLN3 -1.52 6.9.E-03 down 100505839 SH3PXD2A-AS1 -1.52 7.6.E-03 down 79755 ZNF750 -1.51 9.6.E-03 down 55959 SULF2 -1.51 9.2.E-03 down 100507458 ZNF213-AS1 -1.51 9.7.E-03 down 1409 CRYAA -1.50 6.0.E-03 down 51313 FAM198B -1.50 7.2.E-03 down 100852405 RNF185-AS1 -1.50 8.2.E-03 down 29901 SAC3D1 -1.50 9.3.E-03 down 84072 HORMAD1 -1.50 8.6.E-03 down 100874314 TTLL7-IT1 -1.49 6.7.E-03 down 390999 PRAMEF12 -1.49 1.0.E-02 down 11211 FZD10 -1.49 9.8.E-03 down 338707 B4GALNT4 -1.49 7.0.E-03 down 339456 TMEM52 -1.49 6.9.E-03 down 442524 DPY19L2P3 -1.49 1.0.E-02 down 54959 ODAM -1.49 5.5.E-03 down 643401 LINC01021 -1.48 8.1.E-03 down 64105 CENPK -1.47 5.5.E-03 down 221656 KDM1B -1.46 4.8.E-03 down 100306951 PITPNA-AS1 -1.45 9.4.E-03 down 2353 FOS -1.45 3.8.E-03 down 487 ATP2A1 -1.43 9.7.E-03 down 388564 TMEM238 -1.39 8.9.E-03 down 91947 ARRDC4 -1.38 9.8.E-03 down 2713 GK3P -1.34 1.0.E-02 down 10628 TXNIP -1.32 2.9.E-04 down 29128 UHRF1 -1.27 3.9.E-04 down 10635 RAD51AP1 -1.27 6.3.E-03 down 51203 NUSAP1 -1.25 2.7.E-03 down 9582 APOBEC3B -1.22 4.3.E-03 down 9787 DLGAP5 -1.20 5.8.E-03 down

Example 4. Gene Set Enrichment Analysis (GSEA) and Gene Ontology Enrichment Analysis (GSEA)

GSEA was performed using a set of microarray data obtained from human liver and kidney disease to determine whether exposure to PCB77 at gene expression levels is associated with disease status. I used the GSEAPreranked method of GSEA.

GSE23343, hepatocellular carcinoma (HCC), hepatocellular carcinoma, and hepatocellular carcinoma of the liver (T2DM, type 2 diabetes mellitus), steatosis of GSE63067, non-alcoholic steatohepatitis (NASH) A chronic kidney disease (CKD) and a renal cell carcinoma (RCC) data set of GSE66271 were used. DEGs using the limma R package was applied to the GSEA using the gene set.

GSEA results confirmed that upregulated DEGs from four liver diseases and two kidney diseases were significantly enrichment in upregulation of PCB77-treated data sets (FIG. 2A).

GO enrichment analysis was performed to ascertain the biological processes involved in the up-regulated DEGs for PCB77.

The up-regulated DEGs inhibited the regulation of apoptotic process (GO: 0042981, FDR = 1.62e-10), response to unfolded protein (GO: 0006986, FDR = 7.65e -10), response to stress (GO: 0006950, FDR = 1.90e-08), regulation of signal transduction (GO: 0009966, FDR = 2.08e-08) (GO: 0042221, FDR = 6.85e-06) (Fig. 2B).

Although both non-coplanar and coplanar PCBs induce oxidative stress and apoptosis, they act on different pathways. Oxidative stress induced by non-coplanar PCBs activates the Fas receptor signaling pathway, but coplanar PCBs, such as dioxin and dioxin-like chemicals, are strongly associated with AhR (Aryl hydrocarbon receptor). The main role of the AHR pathway is to increase the expression of cytochromes P450 1A1 (CYP1A1), which hydroxylates chemicals when extracorporeal foreign substances enter the body. CYP1A1 decodes polycyclic aromatic compounds and produces mutagenic metabolites and oxidative stress. The binding affinity of AhR differs depending on the chemical structure of the compound. Dioxins have the highest binding affinity, followed by coplanar PCBs and non-coplanar PCBs with the lowest affinity. AhR-dependent CYP1A1 expression levels increased dose-dependently with dioxin treatment. These results indicate that CYP1A1 (FC = 4.25, p = 1.7.E-09) is the most up-regulated DEGs (Table 1). Particularly, since AhR (FC = 1.42, p = 1.67e-02) was not classified as DEG because a very strict threshold (p <0.01) was used in the present invention, when the significance was set to 0.05, Can be regarded as significant. In addition, MYC (MYC proto-oncogene, bHLH transcription factor) and NDRG1 (N-myc downstream regulation 1), which are closely related to the AHR pathway, were also upregulated in DEG under PCB77 exposure (Table 1).

Non-alcoholic fatty liver disease (NAFLD) that can develop into severe liver disorders such as nonalcoholic fatty liver disease (NASH), liver cirrhosis and liver cancer (HCC) in more than 70% of patients with type 2 diabetes (T2DM) , NAFLD). Showed a significant correlation with hepatic impairment of upregulated genes for exposure to PCBs in the present invention (Fig. 2A). In addition, a similar correlation pattern was observed in an expression data set of renal diseases including chronic kidney disease (CKD) and renal cancer (RCC) (Fig. 2A). (FDR = 1.62e-10), response to unfolded protein (FDR = 7.65e-10), response to stress (FDR = 1.90e -08) (Figure 2B), all of which are closely related to endoplasmic reticulum (ER) stress. Although long-term exposure to dioxins and dioxin-like substances is known to interfere with development of the fetal brain and reproductive organs, no significant correlation has been observed in down-regulated genes. This may be because our dataset was obtained primarily from adult human cells with short-term exposure to PCB77 and low sample counts. Taken together, it was found that the main target disease development and pathogenesis of PCB77 is through up-regulated genes.

Example 5. Protein-protein interaction (PPI) network analysis

Protein-protein interaction (PPI) network analysis was performed to understand the biological interaction between up-regulated genes because the expression levels of up-regulated DEGs were significantly associated with liver and kidney disease.

The PPI network and gene ontology (GO) enrichment analysis was performed using the STRING database (v10.5). The interaction sources of this database are: (1) substantial experimental interactions, (2) biological pathway interactions obtained from manually culled databases, (3) text mining interactions based on published papers, (4) (5) cross-species interactions that are systematically applied to other organisms when observed in an organism, but only experimental interactions are used in this invention . The PPI network was visualized with cytoscape software.

The sub-networks are shown using DEGs included in the main five gene ontology (GO) obtained in Figure 2B in the entire PPI network (Figure 3) (Figure 4). The network consists of 50 proteins and 60 interactions. Of the total 50 proteins (Table 2), 23 proteins (Table 3) were involved in the apoptosis process (Figure 4). In particular, the herb protein containing HSP90AB1 (Heat shock protein Alpha Family Class B Member 1, network degree = 10) and HSPA5 (Heat shock protein Family A (Hsp70) Member 5, network degree = 9) (Fig. 2B). The HSP90 dimer binds to the Ahr protein before AHR signaling. Transgenic mice with the HSP90 binding domain (amino acid residues 288-421) promoted liver cancer development. The chaperone protein, HSPA5, is a central regulator involved in the folding of new proteins and refolding of damaged proteins and regulates cell survival and cell death stability in the endoplasmic reticulum. Overall, PPI network analysis showed that HSP90AB1 and HSPA5 were the major proteins involved in liver and kidney toxicity of PCB77.

Gene ID Gene Symbol Fold Change P-value Regulation 2805 GOT1 2.412 1.3.E-04 up 4609 MYC 2.373 5.9.E-05 up 6152 RPL24 2.162 2.6.E-03 up 3326 HSP90AB1 2.119 7.8.E-04 up 2059 EPS8 2.105 4.2.E-04 up 16 AARS 2.089 5.5.E-04 up 3956 LGALS1 2.081 7.0.E-04 up 7316 UBC 2.059 2.5.E-03 up 3091 HIF1A 2.036 3.6.E-03 up 1398 CRK 2.03 5.4.E-04 up 10209 EIF1 2.027 5.6.E-04 up 2673 GFPT1 1.988 1.8.E-03 up 2597 GAPDH 1.985 8.5.E-03 up 6188 RPS3 1.945 5.6.E-03 up 3309 HSPA5 1.942 1.6.E-04 up 2879 GPX4 1.889 3.9.E-03 up 64332 NFKBIZ 1.882 3.5.E-03 up 4189 DNAJB9 1.856 1.8.E-03 up 83939 EIF2A 1.833 2.4.E-03 up 5034 P4HB 1.818 4.6.E-03 up 9093 DNAJA3 1.808 3.0.E-03 up 1453 CSNK1D 1.791 4.2.E-03 up 3337 DNAJB1 1.788 1.2.E-03 up 328 APEX1 1.786 6.8.E-03 up 3912 LAMB1 1.781 5.6.E-03 up 2821 GPI 1.758 6.1.E-03 up 4233 MET 1.757 2.6.E-03 up 2309 FOXO3 1.756 2.4.E-03 up 5495 PPM1B 1.755 5.0.E-03 up 29927 SEC61A1 1.755 2.8.E-03 up 5204 PFDN5 1.747 4.3.E-03 up 140809 SRXN1 1.727 3.9.E-03 up 10134 BCAP31 1.72 7.4.E-03 up 7128 TNFAIP3 1.716 8.2.E-03 up 2197 FAU 1.71 5.9.E-03 up 27 ABL2 1.706 5.5.E-03 up 1728 NQO1 1.7 3.4.E-03 up 5921 RASA1 1.69 9.2.E-03 up 2081 ERN1 1.665 4.9.E-03 up 10049 DNAJB6 1.657 7.5.E-03 up 56652 C10F2 1.656 9.4.E-03 up 10525 HYOU1 1.654 5.5.E-03 up 226 ALDOA 1.632 6.4.E-03 up 23411 SIRT1 1.629 3.4.E-03 up 10542 LAMTOR5 1.617 9.4.E-03 up 5468 PPARG 1.59 6.6.E-03 up 440 ASNS 1.582 2.3.E-03 up 329 BIRC2 1.566 6.1.E-03 up 3329 HSPD1 1.535 9.6.E-03 up 3326 SOS1 1.503 3.0.E-03 up

Gene ID Gene Symbol Fold Change P-value Regulation 4609 MYC 2.373 5.9.E-05 up 3326 HSP90AB1 2.119 7.8.E-04 up 16 AARS 2.089 5.5.E-04 up 3956 LGALS1 2.081 7.0.E-04 up 7316 UBC 2.059 2.5.E-03 up 6188 RPS3 1.945 5.6.E-03 up 3309 HSPA5 1.942 1.6.E-04 up 5034 P4HB 1.818 4.6.E-03 up 9093 DNAJA3 1.808 3.0.E-03 up 2821 GPI 1.758 6.1.E-03 up 2309 FOXO3 1.756 2.4.E-03 up 10134 BCAP31 1.72 7.4.E-03 up 7128 TNFAIP3 1.716 8.2.E-03 up 1728 NQO1 1.7 3.4.E-03 up 5921 RASA1 1.69 9.2.E-03 up 10049 DNAJB6 1.657 7.5.E-03 up 23411 SIRT1 1.629 3.4.E-03 up 10542 LAMTOR5 1.617 9.4.E-03 up 5468 PPARG 1.59 6.6.E-03 up 440 ASNS 1.582 2.3.E-03 up 329 BIRC2 1.566 6.1.E-03 up 3329 HSPD1 1.535 9.6.E-03 up 3326 SOS1 1.503 3.0.E-03 up

Claims (9)

(CHO), HSP90AB1 (Entrez gene ID: 3326), AARS (Entrez gene ID: 3326), which contains a probe binding to the nucleotide sequence of the following gene or a complementary base sequence thereof: MYC ID: 16), LGALS1 (Entrez gene ID 3956), UBC (Entrez gene ID 7316), RPS3 (Entrez gene ID 6188), HSPA5 (Entrez gene ID 3309), P4HB (Entrez gene ID 5034) (Entrez gene ID: 9093), GPI (Entrez gene ID: 2821), FOXO3 (Entrez gene ID: 2309), BCAP31 (Entrez gene ID: 10134), TNFAIP3 (Entrez gene ID: 7128), NQO1 : 1728), RASA1 (Entrez gene ID 5921), DNAJB6 (Entrez gene ID 10049), SIRT1 (Entrez gene ID 23411), LAMTOR5 (Entrez gene ID 10542), PPARG (Entrez gene ID 5468) (Entrez gene ID: 440), BIRC2 (Entrez gene ID: 329), HSPD1 (Entrez gene ID: 3329), and SOS1 (Entrez gene ID: 6654).
The method according to claim 1,
Bifenil 77 Exposure Diagnostic Kits: GOT1 (Entrez Gene ID: 2805), RPL24 (Entrez Gene ID: 6152), EPS8 (Entrez Gene ID: (Entrez Gene ID: 3091), EIF1 (Entrez Gene ID: 10209), GFPT1 (Entrez Gene ID: 2673), GAPDH (Entrez Gene ID: 2597) (Entrez Gene ID: 2879), NFKBIZ (Entrez Gene ID: 64332), DNAJB9 (Entrez Gene ID: 4189), EIF2A (Entrez Gene ID: 83939), CSNK1D (Entrez Gene ID: 1453), DNAJB1 ID: 3337), APEX1 (Entrez Gene ID: 328), LAMB1 (Entrez Gene ID: 3912), MET (Entrez Gene ID: 4233), PPM1B (Entrez Gene ID: 5495), SEC61A1 PFDN5 (Entrez Gene ID 5204), SRXN1 (Entrez Gene ID 140809), FAU (Entrez Gene ID 2197), ABL2 (Entrez Gene ID 27), ERN1 (Entrez Gene ID 2081), C10orf2 : 56652), HYOU1 (Entrez Gene ID: 10525) and ALDOA (Entrez Gene ID: 226) &Lt; / RTI &gt;
The method according to claim 1,
Bifenil 77 Exposure Diagnostic Kits: GOT1 (Entrez Gene ID: 2805), RPL24 (Entrez Gene ID: 6152), EPS8 (Entrez Gene ID: (Entrez Gene ID: 3091), EIF1 (Entrez Gene ID: 10209), GFPT1 (Entrez Gene ID: 2673), GAPDH (Entrez Gene ID: 2597) (Entrez Gene ID: 2879), NFKBIZ (Entrez Gene ID: 64332), DNAJB9 (Entrez Gene ID: 4189), EIF2A (Entrez Gene ID: 83939), CSNK1D (Entrez Gene ID: 1453), DNAJB1 ID: 3337), APEX1 (Entrez Gene ID: 328), LAMB1 (Entrez Gene ID: 3912), MET (Entrez Gene ID: 4233), PPM1B (Entrez Gene ID: 5495), SEC61A1 PFDN5 (Entrez Gene ID 5204), SRXN1 (Entrez Gene ID 140809), FAU (Entrez Gene ID 2197), ABL2 (Entrez Gene ID 27), ERN1 (Entrez Gene ID 2081), C10orf2 : 56652), HYOU1 (Entrez Gene ID: 10525) and ALDOA (Entrez Gene ID: 226).
The method of claim 2,
Biphenyl 77 exposure kit, which further comprises a probe that binds to the nucleotide sequence of the following gene or a complementary base sequence thereof: CYP1A1 (Entrez Gene ID: 1543), MTHFD2 (Entrez Gene ID: 10797), CEBPB Gene ID: 1051), SERTAD2 (Entrez Gene ID: 9792), ZFAS1 (Entrez Gene ID: 441951), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 2649), DDIT3 (Entrez Gene ID: 1649), ERRFI1 (Entrez Gene ID: 54206), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 28474), TRIB3 (Entrez Gene ID: 57761), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502) (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 (Entrez Gene ID: 51187), MAP1B (Entrez Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 : 2274), CCNB1IP1 (Entrez Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1195), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 8412), RPL9 (Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB ), ITGA3 (Entrez Gene ID 3675), ZSWIM6 (Entrez Gene ID 57688), CD63 (Entrez Gene ID 967), NDRGl (Entrez Gene ID 10397), MANF (Entrez Gene ID 7873), YWHAG Gene ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 (Entrez Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 , SOWAHC (Entrez Gene ID: 65124), NARS (Entrez Gene ID: 4677), SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902) ID: 23764), S100A2 (Entrez Gene ID: 6273), MIF (Entrez Gene ID: 4282), WDR45B (Entrez Gene ID: 56270), SERINC1 (Entrez Gene ID: 57515), ASAP2 (Entrez Gene ID: 6386), EVA1A (Entrez Gene ID: 84141), MAP4K3 (Entrez Gene ID: 8491), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 51582), SNAPC1 Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 ), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 (Entrez Gene ID: 3576), NOP58 (Entrez Gene ID: 51602), TMEM69 (Entrez Gene ID: 6190), SELENOS (Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690) (Entrez Gene ID: 1938), MGLL (Entrez Gene ID: 11343), ADM (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 ID: 1604), GHITM (Entrez Gene ID: 27069), IGFBP3 (Entrez Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F 94), PSAP (Entrez Gene ID 5660), SARS (Entrez Gene ID 6301), NSMCE2 (Entrez Gene ID 286053), NIT2 (Entrez Gene ID 56954), PUM1 (Entrez Gene ID 9698), NFXL1 Entrez Gene ID: 152518), EPB41L4A-AS1 (Entrez Gene ID: 114915), STC2 (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 54915), DDX21 (Entrez Gene ID: 9188), MOSPD1 (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 1194), CDK7 (Entrez Gene ID 1022), EIF2S3 (Entrez Gene ID 1968), WWTR1 (Entrez Gene ID 25937), GCLM (Entrez Gene ID 2730), TMEM167B (Entrez Gene ID 56900), CAPG Entrez Gene ID: 822), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 (Entrez Gene ID: 6709), TP53BP2 (Entrez Gene ID: 7159), EIF3D (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 : Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 1350), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), YARS (Entrez Gene ID: (Entrez Gene ID: 7355), RNF149 (Entrez Gene ID: 284996), UPP1 (Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335), PUS7 (Entrez Gene ID: 54517), NONO (Entrez Gene ID: 4841), EIF5 ), TATDN1 (Entrez Gene ID: 83940), CSGALNACT2 (Entrez Gene ID: 55454), ZFAND1 (Entrez Gene ID: 79752), AMD1 (Entrez Gene ID: 262), FAT1 ), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018), OAZ1 (Entrez Gene ID: 4946), SLC19A2 (Entrez Gene ID: 10560), GNS Gene ID: 6856), TRAM1 (Entrez Gene ID: 23471), NMD3 (Entrez Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 51388), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 7076), BNIP3L (Entrez Gene ID: 665), SH3RF1 (Entrez Gene ID: 57630), BUD31 (Entrez Gene ID: 8896), BEX2 (Entrez Gene ID: 84707), HSPA13 (Entrez Gene ID: 6999), GTB2H3 (Entrez Gene ID: 2967), SLC25A38 (Entrez Gene ID: 54977), SEC22B (Entrez Gene ID: 9554), CXorf40B : Entrez Gene ID: 23325), CDYL (Entrez Gene ID: 9425), FAM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 746), IL6R (Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55353), CDV3 (Entrez Gene ID: 55573), NAXD (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 268), WBI (Entrez Gene ID: 263), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 304), LINC00493 Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341), ATP6V1A (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 ), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 Gene ID: 90), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441) (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 5292), EDEM3 (Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 84803), AMMECR1L (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 23199), TMEM268 (Entrez Gene ID: 203197), RPL22L1 (Entrez Gene ID: Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 5876), EBLN3P (Entrez Gene ID: 100506710), VAMP8 (Entrez Gene ID: 8673), NFE2L1 (Entrez Gene ID: 4779), CXorf40A ), TNFRSF12A (Entrez Gene ID: 51330), GPT2 (Entrez Gene ID: 84706), TMED2 (Entrez Gene ID: 10959), SLC38A1 39), FNBP1L (Entrez Gene ID 54874), TNFSF10 (Entrez Gene ID 8743), AKAP12 (Entrez Gene ID 9590), CEBPG (Entrez Gene ID 1054), SAT2 (Entrez Gene ID 112483), ABHD3 Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227), VGF (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN ), PHF10 (Entrez Gene ID: 55274), ZSCAN29 (Entrez Gene ID: 146050), MIEF1 (Entrez Gene ID: 54471), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 10253), ETFB (Entrez Gene ID: 2109), ACYP2 (Entrez Gene ID: 98), CRIM1 (Entrez Gene ID: 51232), RNF146 ID: 81847), CCL20 (Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 6879), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 (Entrez Gene ID: 10379), SCYL2 (Entrez Gene ID: 55681), KLF5 ), SEC24B (Entrez Gene ID: 10427), KLHL23 (Entrez Gene ID: 151230), LONP1 (Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 (Entrez Gene ID: 10467), SERPINE1 Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 (Entrez Gene ID: 18232), MEGF9 (Entrez Gene ID: 2267), AKP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: ID No. 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 (Entrez Gene ID: 51315), JMY (Entrez Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: (Entrez Gene ID: 5707), ND6 (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 (Entrez Gene ID: 57088), RBM24 Entrez Gene ID: 221662), HSD11B2 (Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 ), NFE2 (Entrez Gene ID: 4778), LRRC45 (Entrez Gene ID: 201255), ZNF385C (Entrez Gene ID: 201181), EGR3 (Entrez Gene ID: 1960), UBL7- (Entrez Gene ID: 167826), GAPT (Entrez Gene ID: 202309), FDXR (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 ID: 5307), CCDC144NL-AS1 (Entrez Gene ID: 440416), CCDC69 (Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482 ), SOX18 (Entrez Gene ID: 54345), DPP10 (Entrez Gene ID: 57628), LINC01209 (Entrez Gene ID: 101928684), USP3-AS1 PCDHB14 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), ZNF417 (Entrez Gene ID: 147687), P2RY13 (Entrez Gene ID: (Enterre Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA (Entrez Gene ID: 1409), FAM198B ID No. 51313), RNF185-AS1 (Entrez Gene ID 100852405), SAC3D1 (Entrez Gene ID 29901), HORMAD1 (Entrez Gene ID 84072), TTLL7-IT1 (Entrez Gene ID 100874314), PRAMEF12 (Entrez Gene ID: 449524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 4,959), FZD10 (Entrez Gene ID: 11211), B4GALNT4 (Entrez Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 64105), KDM1B (Entrez Gene ID: 221656), PITPNA-AS 1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353), ATP2A1 (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 91947), GK3P : 2713), TXNIP (Entrez Gene ID: 10628), UHRF1 (Entrez Gene ID: 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9787).
The method of claim 3,
Biphenyl 77 exposure kit, which further comprises a probe that binds to the nucleotide sequence of the following gene or a complementary base sequence thereof: CYP1A1 (Entrez Gene ID: 1543), MTHFD2 (Entrez Gene ID: 10797), CEBPB Gene ID: 1051), SERTAD2 (Entrez Gene ID: 9792), ZFAS1 (Entrez Gene ID: 441951), SLC22A15 (Entrez Gene ID: 55356), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 2649), DDIT3 (Entrez Gene ID: 1649), ERRFI1 (Entrez Gene ID: 54206), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 28474), TRIB3 (Entrez Gene ID: 57761), SLC25A6 (Entrez Gene ID: 293), MT2A (Entrez Gene ID: 4502) (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 (Entrez Gene ID: 51187), MAP1B (Entrez Gene ID: 4131), IARS (Entrez Gene ID: 3376), FHL2 : 2274), CCNB1IP1 (Entrez Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1195), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 8412), RPL9 (Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB ), ITGA3 (Entrez Gene ID 3675), ZSWIM6 (Entrez Gene ID 57688), CD63 (Entrez Gene ID 967), NDRGl (Entrez Gene ID 10397), MANF (Entrez Gene ID 7873), YWHAG Gene ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 (Entrez Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 , SOWAHC (Entrez Gene ID: 65124), NARS (Entrez Gene ID: 4677), SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902) ID: 23764), S100A2 (Entrez Gene ID: 6273), MIF (Entrez Gene ID: 4282), WDR45B (Entrez Gene ID: 56270), SERINC1 (Entrez Gene ID: 57515), ASAP2 (Entrez Gene ID: 6386), EVA1A (Entrez Gene ID: 84141), MAP4K3 (Entrez Gene ID: 8491), INPP1 (Entrez Gene ID: 3628), AZIN1 (Entrez Gene ID: 51582), SNAPC1 Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 7114), XPOT (Entrez Gene ID: 11260), RBMS1 ), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 (Entrez Gene ID: 3576), NOP58 (Entrez Gene ID: 51602), TMEM69 (Entrez Gene ID: 6190), SELENOS (Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902), LSM7 (Entrez Gene ID: 51690) (Entrez Gene ID: 1938), MGLL (Entrez Gene ID: 11343), ADM (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 ID: 1604), GHITM (Entrez Gene ID: 27069), IGFBP3 (Entrez Gene ID: 3486), TMEM181 (Entrez Gene ID: 57583), OSMR (Entrez Gene ID: 9180), MT1F 94), PSAP (Entrez Gene ID 5660), SARS (Entrez Gene ID 6301), NSMCE2 (Entrez Gene ID 286053), NIT2 (Entrez Gene ID 56954), PUM1 (Entrez Gene ID 9698), NFXL1 Entrez Gene ID: 152518), EPB41L4A-AS1 (Entrez Gene ID: 114915), STC2 (Entrez Gene ID: 8614), PNPLA8 (Entrez Gene ID: 50640), RPS4Y1 (Entrez Gene ID: 6192), RPL22 (Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 54915), DDX21 (Entrez Gene ID: 9188), MOSPD1 (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 26762), C6orf48 (Entrez Gene ID: 50854), SHMT2 1194), CDK7 (Entrez Gene ID 1022), EIF2S3 (Entrez Gene ID 1968), WWTR1 (Entrez Gene ID 25937), GCLM (Entrez Gene ID 2730), TMEM167B (Entrez Gene ID 56900), CAPG Entrez Gene ID: 822), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 (Entrez Gene ID: 6709), TP53BP2 (Entrez Gene ID: 7159), EIF3D (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 : Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 1350), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 5730), C3 (Entrez Gene ID: 718), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), YARS (Entrez Gene ID: (Entrez Gene ID: 7355), RNF149 (Entrez Gene ID: 284996), UPP1 (Entrez Gene ID: 7378), SLC7A11 (Entrez Gene ID: 23657), CYR61 (Entrez Gene ID: 3491), NABP1 Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335), PUS7 (Entrez Gene ID: 54517), NONO (Entrez Gene ID: 4841), EIF5 ), TATDN1 (Entrez Gene ID: 83940), CSGALNACT2 (Entrez Gene ID: 55454), ZFAND1 (Entrez Gene ID: 79752), AMD1 (Entrez Gene ID: 262), FAT1 ), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018), OAZ1 (Entrez Gene ID: 4946), SLC19A2 (Entrez Gene ID: 10560), GNS Gene ID: 6856), TRAM1 (Entrez Gene ID: 23471), NMD3 (Entrez Gene ID: 51068), APEX1 (Entrez Gene ID: 328), PPIB (Entrez Gene ID: 5479), TAX1BP1 (Entrez Gene ID: 9943), RB1CC1 (Entrez Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 51388), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEH1 (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 7076), BNIP3L (Entrez Gene ID: 665), SH3RF1 (Entrez Gene ID: 57630), BUD31 (Entrez Gene ID: 8896), BEX2 (Entrez Gene ID: 84707), HSPA13 (Entrez Gene ID: 6999), GTB2H3 (Entrez Gene ID: 2967), SLC25A38 (Entrez Gene ID: 54977), SEC22B (Entrez Gene ID: 9554), CXorf40B : Entrez Gene ID: 23325), CDYL (Entrez Gene ID: 9425), FAM171A1 (Entrez Gene ID: 221061), TMEM258 (Entrez Gene ID: 746), IL6R (Entrez Gene ID: 3570), LAPTM4B (Entrez Gene ID: 55353), CDV3 (Entrez Gene ID: 55573), NAXD (Entrez Gene ID: 55739), WSB2 (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 268), WBI (Entrez Gene ID: 263), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 (Entrez Gene ID: 304), LINC00493 Entrez Gene ID: 586), VAMP3 (Entrez Gene ID: 9341), ATP6V1A (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 ), LYSMD3 (Entrez Gene ID: 116068), GNA13 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 Gene ID: 90), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 90441) (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 5292), EDEM3 (Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 (Entrez Gene ID: 7716), CHSY1 (Entrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 84803), AMMECR1L (Entrez Gene ID: 83607), ZNF394 (Entrez Gene ID: 23199), TMEM268 (Entrez Gene ID: 203197), RPL22L1 (Entrez Gene ID: Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 5876), EBLN3P (Entrez Gene ID: 100506710), VAMP8 (Entrez Gene ID: 8673), NFE2L1 (Entrez Gene ID: 4779), CXorf40A ), TNFRSF12A (Entrez Gene ID: 51330), GPT2 (Entrez Gene ID: 84706), TMED2 (Entrez Gene ID: 10959), SLC38A1 39), FNBP1L (Entrez Gene ID 54874), TNFSF10 (Entrez Gene ID 8743), AKAP12 (Entrez Gene ID 9590), CEBPG (Entrez Gene ID 1054), SAT2 (Entrez Gene ID 112483), ABHD3 Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227), VGF (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN ), PHF10 (Entrez Gene ID: 55274), ZSCAN29 (Entrez Gene ID: 146050), MIEF1 (Entrez Gene ID: 54471), MXI1 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 Gene ID: 26260), STK39 (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 51430), SPRY2 (Entrez Gene ID: 10253), ETFB (Entrez Gene ID: 2109), ACYP2 (Entrez Gene ID: 98), CRIM1 (Entrez Gene ID: 51232), RNF146 ID: 81847), CCL20 (Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 6879), CDKN1B (Entrez Gene ID: 1027), EPC2 (Entrez Gene ID: 26122), IRF9 (Entrez Gene ID: 10379), SCYL2 (Entrez Gene ID: 55681), KLF5 ), SEC24B (Entrez Gene ID: 10427), KLHL23 (Entrez Gene ID: 151230), LONP1 (Entrez Gene ID: 9361), PAPD7 (Entrez Gene ID: 11044), ZNHIT1 (Entrez Gene ID: 10467), SERPINE1 Gene ID: 5054), PNRC2 (Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 (Entrez Gene ID: 18232), MEGF9 (Entrez Gene ID: 2267), AKP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: ID No. 1955), ROBO1 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 (Entrez Gene ID: 51315), JMY (Entrez Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: (Entrez Gene ID: 5707), ND6 (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 (Entrez Gene ID: 57088), RBM24 Entrez Gene ID: 221662), HSD11B2 (Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958), ALDH8A1 (Entrez Gene ID: 64577), CHST9 (Entrez Gene ID: 83539), TUBBP5 ), NFE2 (Entrez Gene ID: 4778), LRRC45 (Entrez Gene ID: 201255), ZNF385C (Entrez Gene ID: 201181), EGR3 (Entrez Gene ID: 1960), UBL7- (Entrez Gene ID: 167826), GAPT (Entrez Gene ID: 202309), FDXR (Entrez Gene ID: 2232), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 ID: 5307), CCDC144NL-AS1 (Entrez Gene ID: 440416), CCDC69 (Entrez Gene ID: 26112), PDZRN4 (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482 ), SOX18 (Entrez Gene ID: 54345), DPP10 (Entrez Gene ID: 57628), LINC01209 (Entrez Gene ID: 101928684), USP3-AS1 PCDHB14 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), ZNF417 (Entrez Gene ID: 147687), P2RY13 (Entrez Gene ID: (Enterre Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A-AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA (Entrez Gene ID: 1409), FAM198B ID No. 51313), RNF185-AS1 (Entrez Gene ID 100852405), SAC3D1 (Entrez Gene ID 29901), HORMAD1 (Entrez Gene ID 84072), TTLL7-IT1 (Entrez Gene ID 100874314), PRAMEF12 (Entrez Gene ID: 449524), ODAM (Entrez Gene ID: 54959), LINC01021 (Entrez Gene ID: 4,959), FZD10 (Entrez Gene ID: 11211), B4GALNT4 (Entrez Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 64105), KDM1B (Entrez Gene ID: 221656), PITPNA-AS 1 (Entrez Gene ID: 100306951), FOS (Entrez Gene ID: 2353), ATP2A1 (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 91947), GK3P : 2713), TXNIP (Entrez Gene ID: 10628), UHRF1 (Entrez Gene ID: 29128), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9787).
6. The method according to any one of claims 1 to 5,
The diagnostic kit is a microarray polychlorinated biphenyl 77 exposure kit.
A method for providing polychlorinated biphenyl 77 exposure information comprising the step of hybridizing a diagnostic kit according to any one of claims 1 to 5 with a cDNA of liver or kidney disease cell line.
The method of claim 7,
(B) determining whether the expression of the gene of interest is increased when exposed to polychlorinated biphenyl 77. 77. The method of claim 1, further comprising the step of: (a) (Entrez Gene ID: 5407), SLC38A2 (Entrez Gene ID: 54407), DUSP6 (Entrez Gene ID: 5,351), CEBPB (Entrez Gene ID: 1051), SERTAD2 (Entrez Gene ID: 1649), ERRFI1 (Entrez Gene ID: 54206), GOT1 (Entrez Gene ID: 2805), AGO2 (Entrez Gene ID: 27161), MT1M (Entrez Gene ID: 4499) (Entrez Gene ID: 2617), DDIT4 (Entrez Gene ID: 54541), DUSP5 (Entrez Gene ID: 1847), LURAP1L (Entrez Gene ID: 286343), TRIB3 (Entrez Gene ID: 57761), SLC25A6 : 293), MT2A (Entrez Gene ID: 4502), INHBE (Entrez Gene ID: 83729), ATF4 (Entrez Gene ID: 468), RSL24D1 (Entrez Gene ID: 51187) (Entrez Gene ID: 3376), FHL2 (Entrez Gene ID: 2274), CCNB1IP1 (Entrez Gene ID: 57820), RPL7L1 (Entrez Gene ID: 285855), RPL37 (Entrez Gene ID: 6167), CLK1 (Entrez Gene ID: 1195), PLAU (Entrez Gene ID: 5328), TMSB10 (Entrez Gene ID: 9168), MAP1LC3B (Entrez Gene ID: 81631), EEF1A2 (Entrez Gene ID: 1917), MT1X (Entrez Gene ID: 4501), BCAR3 (Entrez Gene ID: 8412), RPL24 Entrez Gene ID: 6133), NT5C3A (Entrez Gene ID: 51251), HEXB (Entrez Gene ID: 3074), ITGA3 (Entrez Gene ID: 3675), ZSWIM6 (Entrez Gene ID: 57688), CD63 ), EPS8 (Entrez Gene ID: 2059), NDRG1 (Entrez Gene ID: 10397), MANF (Entrez Gene ID: 7873), YWHAG (Entrez Gene ID: 7532), CTH (Entrez Gene ID: 1491), RSRC2 Gene ID: 65117), CCT2 (Entrez Gene ID: 10576), PTTG1IP (Entrez Gene ID: 754), RPL39 (Entrez Gene ID: 6170), SOWAHC (Entrez Gene ID: 65124), NARS , SLC3A2 (Entrez Gene ID: 6520), RPL27 (Entrez Gene ID: 6155), AMIGO2 (Entrez Gene ID: 347902), MAFF (Entrez Gene ID: 23764), S100A2 (Entrez Gene ID: 4282), HIF1A (Entrez Gene ID: 3091), WDR45B (Entrez Gene ID: 56270), CRK (Entrez Gene ID: 1398), EIF1 (Entrez Gene ID: 10209), SERINC1 (Entrez Gene ID: 8828), SDCBP (Entrez Gene ID: 6386), EVA1A (Entrez Gene ID: 84141), MAP4K3 (Entrez Gene ID: 8491), INPP1 Entrez Gene ID: 51582), SNAPC1 (Entrez Gene ID: 6617), SAT1 (Entrez Gene ID: 6303), RPL23A (Entrez Gene ID: 6147), TMSB4X (Entrez Gene ID: 7114), XPOT ), RBMS1 (Entrez Gene ID: 5937), PFKFB3 (Entrez Gene ID: 5209), TOMM20 (Entrez Gene ID: 9804), CXCL8 (Entrez Gene ID: 3576), NOP58 (Entrez Gene ID: 51602) (Entrez Gene ID: 5621), RPL29 (Entrez Gene ID: 6159), SELENOS (Entrez Gene ID: 55829), RPL8 (Entrez Gene ID: 6132), TBCA (Entrez Gene ID: 6902) , GFPD1 (Entrez Gene ID: 2673), EEF2 (Entrez Gene ID: 1938), MGLL (Entrez Gene ID: 11343), GAPDH (Entrez Gene ID: 2597), ADM (Entrez Gene ID: 133), SSR4 (Entrez Gene ID: 6748), PLPP2 (Entrez Gene ID: 8612), CD55 (Entrez Gene ID: 1604), GHITM (Entrez Gene ID: 27069), IGFBP3 3486), TMEM181 (Entrez Gene ID 57583), OSMR (Entrez Gene ID 9180), MT1F (Entrez Gene ID 4494), PSAP (Entrez Gene ID 5660), SARS (Entrez Gene ID 6301), NSMCE2 Entrez Gene ID: 286053), NIT2 (Entrez Gene ID: 56954), PUM1 (Entrez Gene ID: 9698), NFXL1 (Entrez Gene ID: 152518), EPB41L4A- (Entrez Gene ID: 5602), RPL22 (Entrez Gene ID: 6146), BAG3 (Entrez Gene ID: 9531), SELENOK (Entrez Gene ID: 58515), PPP1R15A (Entrez Gene ID: 23645), RPL11 (Entrez Gene ID: 6135), YTHDF1 (Entrez Gene ID: 54915), DDX21 (Entrez Gene ID: 9188), MOSPD1 (Entrez Gene ID: 56180), HAVCR1 (Entrez Gene ID: 6472), CLIC1 (Entrez Gene ID: 1192), CDK7 (Entrez Gene ID: 1022), EIF2S3 (Entrez Gen (Entrez Gene ID: 2879), GCLM (Entrez Gene ID: 2730), TMEM167B (Entrez Gene ID: 56900), NFKBIZ (Entrez Gene ID: 64332) (Entrez Gene ID: 822), F2RL1 (Entrez Gene ID: 2150), MT1H (Entrez Gene ID: 4496), RRN3 (Entrez Gene ID: 4512), PDZK1IP1 (Entrez Gene ID: 10158), ATG101 (Entrez Gene ID: 7159), EIF3D (Entrez Gene ID: 8664), RPS24 (Entrez Gene ID: 6229), HERPUD1 (Entrez Gene ID: 9709), PDGFC (Entrez Gene ID: 56034) (Entrez Gene ID: 8140), RPF2 (Entrez Gene ID: 84154), COX7C (Entrez Gene ID: 1350), DNAJB9 (Entrez Gene ID: 4189), CHMP4C (Entrez Gene ID: 92421), PTGDS (Entrez Gene ID: 7165), CLDN1 (Entrez Gene ID: 9076), IFRD1 (Entrez Gene ID: 3475), EIF2A (Entrez Gene ID: 83939), YARS (Entrez Gene ID: 4179), SMNDC1 (Entrez Gene ID: 10285), TPD52L2 (Entrez Gene ID: 7165), RNF149 (Entrez Gene ID: 284996), UPP1 (Entrez Gene ID: 3491), NABP1 (Entrez Gene ID: 64859), KLF6 (Entrez Gene ID: 1316), FN1 (Entrez Gene ID: 2335), PUS7 (Entrez Gene ID: 54517) ), NONO (Entrez Gene ID: 4841), EIF5 (Entrez Gene ID: 1983), TATDN1 (Entrez Gene ID: 83940), CSGALNACT2 (Entrez Gene ID: 55454), ZFAND1 Gene ID: 262), FAT1 (Entrez Gene ID: 2195), EDF1 (Entrez Gene ID: 8721), OXA1L (Entrez Gene ID: 5018), OAZ1 (Entrez Gene ID: 4946), SLC19A2 (Entrez Gene ID: 2799), CSNK1D (Entrez Gene ID: 1453), SYPL1 (Entrez Gene ID: 6856), TRAM1 (Entrez Gene ID: 23471), DNAJB1 (Entrez Gene ID: 3337), NMD3 (Entrez Gene ID: 4999), TAX1BP1 (Entrez Gene ID: 8887), LAMB1 (Entrez Gene ID: 3912), OXSR1 (Entrez Gene ID: 9943) (Enterre Gene ID: 9821), MT1E (Entrez Gene ID: 4493), IMPA1 (Entrez Gene ID: 3612), IRF2BPL (Entrez Gene ID: 64207), ANXA3 (Entrez Gene ID: 306), NIP7 ez Gene ID: 51388), GCLC (Entrez Gene ID: 2729), COX6C (Entrez Gene ID: 1345), NCEHl (Entrez Gene ID: 57552), CAB39 (Entrez Gene ID: 51719), TIMP1 ), BNIP3L (Entrez Gene ID 665), SH3RF1 (Entrez Gene ID 57630), BUD31 (Entrez Gene ID 8896), BEX2 (Entrez Gene ID 84707), HSPA13 (Entrez Gene ID 6782), TMBIM6 Entrez Gene ID: 4233), GTF2H3 (Entrez Gene ID: 2967), SEC61A1 (Entrez Gene ID: 29927), PPM1B (Entrez Gene ID: 5495), SLC25A38 (Entrez Gene ID: 54977) (Entrez Gene ID: 9525), PFDN5 (Entrez Gene ID: 5204), CXorf40B (Entrez Gene ID: 541578), KIAA1033 (Entrez Gene ID: 23325), CDYL (Entrez Gene ID: 9425), FAM171A1 (Entrez Gene ID: 55773), NAXD (Entrez Gene ID: 55739), LAPTM4B (Entrez Gene ID: 55353) (Entrez Gene ID: 55884), WDR83OS (Entrez Gene ID: 51398), SLC35B1 (Entrez Gene ID: 10237), UBTD2 (Entrez Gene ID: 92181), ANXA2P2 Wnt82 (Entrez Gene ID: 80335), MYOF (Entrez Gene ID: 26509), BCAT1 (Entrez Gene ID: 586), SRXN1 (Entrez Gene ID: 140809), LINC00493 (Entrez Gene ID: 388789) (Entrez Gene ID: 9341), ATP6V1A (Entrez Gene ID: 523), WARS (Entrez Gene ID: 7453), UBP1 (Entrez Gene ID: 7342), CDK8 (Entrez Gene ID: 1024), LYSMD3 (Entrez Gene ID: 10672), TMEM41B (Entrez Gene ID: 440026), SEC16A (Entrez Gene ID: 9919), MALT1 (Entrez Gene ID: 10892), ACVR1 (Entrez Gene ID: 2197), SNX9 (Entrez Gene ID: 51429), FZD6 (Entrez Gene ID: 8323), ABL2 (Entrez Gene ID: 27), CPE (Entrez Gene ID: 1363), ZNF622 (Entrez Gene ID: 389203), DSG2 (Entrez Gene ID: 1829), MAK16 (Entrez Gene ID: 84549), RMND1 (Entrez Gene ID: 55005), UBE2S (Entrez Gene ID: 27338), INSIG2 (Entrez Gene ID: 51141), PIM1 (Entrez Gene ID: 5292), EDEM3 (Entrez Gene ID: 80267), MED10 (Entrez Gene ID: 84246), VEZF1 ntrez Gene ID: 22856), ATF1 (Entrez Gene ID: 466), RALA (Entrez Gene ID: 5898), MTERF3 (Entrez Gene ID: 51001), GPAT3 (Entrez Gene ID: 84803), AMMECR1L ), ZNF394 (Entrez Gene ID: 84124), PWP1 (Entrez Gene ID: 11137), RSL1D1 (Entrez Gene ID: 26156), APP (Entrez Gene ID: 351), RYBP (Entrez Gene ID: 23429), TMEM268 Gene ID: 203197), ERN1 (Entrez Gene ID: 2081), RPL22L1 (Entrez Gene ID: 200916), RABGGTB (Entrez Gene ID: 5876), EBLN3P (Entrez Gene ID: 100506710), VAMP8 (Entrez Gene ID: 4779), C10orf2 (Entrez Gene ID: 56652), CXorf40A (Entrez Gene ID: 91966), HYOU1 (Entrez Gene ID: 10525), TNFRSF12A (Entrez Gene ID: 51330), GPT2 ID: 84706), TMED2 (Entrez Gene ID: 10959), SLC38A1 (Entrez Gene ID: 81539), FNBP1L (Entrez Gene ID: 54874), TNFSF10 (Entrez Gene ID: 8743), AKAP12 CEBPG (Entrez Gene ID: 1054), SAT2 (Entrez Gene ID: 112483), ABHD3 (Entrez Gene ID: 171586), PHGDH (Entrez Gene ID: 26227) (Entrez Gene ID: 7425), HEATR5A (Entrez Gene ID: 25938), ESF1 (Entrez Gene ID: 51575), OPTN (Entrez Gene ID: 10133), PHF10 (Entrez Gene ID: 26260), STK39 (Entrez Gene ID: 4601), S100A10 (Entrez Gene ID: 6281), FBXO25 (Entrez Gene ID: 26260) (Entrez Gene ID: 27347), RNF11 (Entrez Gene ID: 26994), NOP14 (Entrez Gene ID: 8602), YAP1 (Entrez Gene ID: 10413), PCK2 (Entrez Gene ID: 10253), ETFB (Entrez Gene ID: 2109), ACYP2 (Entrez Gene ID: 98), CRIM1 (Entrez Gene ID: 51232), RNF146 (Entrez Gene ID: 81847), CCL20 Entrez Gene ID: 6364), CXCL16 (Entrez Gene ID: 58191), CLDN12 (Entrez Gene ID: 9069), CTSA (Entrez Gene ID: 5476), LINC00888 (Entrez Gene ID: 100505687), SCYL2 ), KLF5 (Entrez Gene ID 688), CDKN1B (Entrez Gene ID 1027), EPC2 (Entrez Gene ID 26122), IRF9 (Entrez Gene ID 10379), SEC24B (Entrez Gene ID: 10427), SERPINE1 (Entrez Gene ID: 5054), POND1 (Entrez Gene ID: , Entrez Gene ID: 55629), LOC100506498 (Entrez Gene ID: 100506498), SEMA4C (Entrez Gene ID: 54910), SASH1 (Entrez Gene ID: 23328), HSD17B11 (Entrez Gene ID: 51170), FAM110C ID: 642273), SETD1B (Entrez Gene ID: 23067), RPP40 (Entrez Gene ID: 10799), AKAP17A (Entrez Gene ID: 8227), DSP (Entrez Gene ID: 1832), MEGF9 (Entrez Gene ID: 6091), C8orf76 (Entrez Gene ID: 84933), GRB10 (Entrez Gene ID: 2887), LOC149703 (Entrez Gene ID: 149703), NR1D2 (Entrez Gene ID: 9975), KRCC1 : Entire Gene ID: 133746), SGK223 (Entrez Gene ID: 157285), CAP2 (Entrez Gene ID: 10486), IER3 (Entrez Gene ID: 8870), RGS2 (Entrez Gene ID: 5997), ND6 (Entrez Gene ID: 4541), SLC16A6 (Entrez Gene ID: 9120), PLSCR4 (Entrez Gene ID: 57088) and RBM24 (Entrez Gene ID: 221662) At least one or all selected from the group consisting of
The method of claim 7,
(BRIEF DESCRIPTION OF THE DRAWINGS) FIG. 1 is a flow chart of an embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Exposure information: HSD11B2 (Entrez Gene ID: 3291), EGR1 (Entrez Gene ID: 1958) , Entrez Gene ID: 64557), CHST9 (Entrez Gene ID: 83539), TUBBP5 (Entrez Gene ID: 643224), NFE2 (Entrez Gene ID: 4778), LRRC45 (Entrez Gene ID: 201255), ZNF385C (Entrez Gene ID: 1960), UBL7-AS1 (Entrez Gene ID: 440288), OLIG3 (Entrez Gene ID: 167826), GAPT (Entrez Gene ID: 202309), FDXR (Entrez Gene ID: 2232 ), C10orf71-AS1 (Entrez Gene ID: 100506769), GPX7 (Entrez Gene ID: 2882), PITX1 (Entrez Gene ID: 5307), CCDC144NL- AS1 (Entrez Gene ID: 440416), CCDC69 (Entrez Gene ID: 26112) (Entrez Gene ID: 29951), E2F8 (Entrez Gene ID: 79733), LOC101927482 (Entrez Gene ID: 101927482), SOX18 (Entrez Gene ID: 54345), DPP10 (Entrez Gene ID: 57628), LINC01209 ID: 101928684), USP3-AS1 (Entrez Ge PCDHB14 (Entrez Gene ID: 56122), CD7 (Entrez Gene ID: 924), ZNF417 (Entrez Gene ID: 147687), P2RY13 (Entrez Gene ID: (Entrez Gene ID: 54363), ZNF252P-AS1 (Entrez Gene ID: 286103), IQCF4 (Entrez Gene ID: 100506840), XKRX (Entrez Gene ID: 402415), UBQLN3 (Entrez Gene ID: 50613), SH3PXD2A- AS1 (Entrez Gene ID: 100505839), ZNF750 (Entrez Gene ID: 79755), SULF2 (Entrez Gene ID: 55959), ZNF213-AS1 (Entrez Gene ID: 100507458), CRYAA (Entrez Gene ID: 1409), FAM198B Gene ID: 51313), RNF185-AS1 (Entrez Gene ID: 100852405), SAC3D1 (Entrez Gene ID: 29901), HORMAD1 (Entrez Gene ID: 84072), TTLL7- ID: 390999), FZD10 (Entrez Gene ID: 11211), B4GALNT4 (Entrez Gene ID: 338707), TMEM52 (Entrez Gene ID: 339456), DPY19L2P3 (Entrez Gene ID: 442524) LENC01021 (Entrez Gene ID: 643401), CENPK (Entrez Gene ID: 64105), KDM1B (Entrez Gene ID: 221656), PITPNA (Entrez Gene ID: 3,193), ATP2A1 (Entrez Gene ID: 487), TMEM238 (Entrez Gene ID: 388564), ARRDC4 (Entrez Gene ID: 91947), GK3P (Entrez Gene ID: (Entrez Gene ID: 10682), RAD51AP1 (Entrez Gene ID: 10635), NUSAP1 (Entrez Gene ID: 51203), APOBEC3B (Entrez Gene ID: 9582) DLGAP5 (Entrez Gene ID: 9787).

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