KR101926829B1 - Intravascular blood pump - Google Patents

Abstract

A foldable blood pump 10 insertable into a blood vessel includes a foldable radial transfer impeller 20 housed within a foldable housing or envelope 24. A clearance 60 is provided between the impeller 20 and the front and rear walls 32 and 62 of the housing 24 and the clearance is at least 0.2 mm. Preferably, the space defined between the adjacent blades 54 of the impeller 20 is open toward the front wall 32 of the housing 24.

Description

[0001] INTRAVASCULAR BLOOD PUMP [0002]

The present invention relates to an intravascularly inserted, further comprising a catheter for housing a flexible shaft connected to an external motor for driving the impeller, comprising a housing arranged with a radially delivering impeller for rotation, As well as to a possible blood pump. More particularly, the present invention relates to an expandable intravascular blood pump.

It is known that a rotary blood pump is inserted into the heart to support the pumping capacity of the natural heart. Insertion is performed in the blood vessel, i. E. Through the vasculature of the patient. Therefore, it is important that, upon insertion, the maximum diameter of the vascular pump is small, preferably not exceeding 4 mm (12 French). In addition, the vascular pump should be flexible to accommodate the bending of the vascular path.

The aforementioned rotating blood pumps currently in use are axial transfer blood pumps, that is, they have axial inlet and axial outlet spaced therefrom, with an axial transfer impeller therebetween. Thus, the maximum pumped blood flow is limited by two factors, the cross-sectional diameter through which the impeller delivers the flow, and the rotational speed at which the impeller is driven. An additional increase in diameter is limited by vessel size. Further increases in rotational speed are difficult due to blood damage.

Accordingly, an impeller itself and a housing in which an impeller rotates can be arranged from a foldable structure to a non-foldable operation structure (US Pat. No. 4,753,221; US Pat. No. 4,919,647; US Pat. No. 5,749,855 , US 6,533,716, and US 7,841,976). If the insertion of an intravascular intravenous pump is performed via a catheter, the maximum diameter of the expandable blood pump should not exceed 4 mm (12 French), while the cross-sectional diameter at deployment may be 9 mm (27 French) .

A serious problem with an axial-flowable blood pump is that the accuracy of the dimensions is required. The rotor should conform to very precise tolerances to the internal shape of the housing to obtain a flow rate of at least 2 l / min (liters per minute) under physiological pressure conditions without excessive blood breakage. Due to the flexibility of the foldable housing, this requirement is difficult to realize with a foldable blood pump. More particularly, there is always the risk that the housing can not completely presume a predefined shape, especially due to bending in the vein path during use. Instead, an unexpected force acting locally on the flexible housing can cause the impeller to contact the inner wall of the housing, which can quickly cause destruction of the entire device or an unacceptable level of blood damage and some loss of the patient ' s body .

There is another proposal of a foldable blood pump, such as US 5,827,171, which employs concentric balloons instead of impellers. These balloons are actually swollen and evacuated to repeatedly collapse and inflate the innermost balloon that pumps blood. US 2008/0103591 A1 proposes an intravascularly insertable, foldable blood pump wherein the impeller is a radial transfer impeller rather than an axial transfer impeller. Not only does the radial transfer impeller require a relatively low speed of approximately 5,000 to 15,000 rpm to deliver a typical amount of blood of approximately 2 to 5 l / min, but additionally, such centrifugal pumps require no precise radial tolerance between the impeller and the housing . This is due to the fact that blood collides against the circumferential wall of the housing and is radially ejected from the impeller blades and the wall redirects the blood axially away from the radial direction. As a result, there can be a large radial gap between the impeller blade and the circumferential housing wall. However, if there is a gap between the front wall of the housing and the impeller blade, and there is a rear wall of the housing, the gap between the rear wall of the housing and the impeller blade is about 0.1 mm to prevent unwanted return flow of blood It will be kept small. This is illustrated with respect to various embodiments, wherein in one embodiment the blades are held between two plates that are attached to and extend radially from the drive shaft in a spaced apart relation, Rather than between the spokes and the spokes are attached to the drive shaft and extend radially therefrom.

Thus, a precise tolerance between the impeller and the housing is not required in the radial direction, but is still required in the axial direction, thereby causing a risk of failure if the housing is deformed towards the impeller under external load or internal stress.

It is therefore an object of the present invention to further reduce the risk of failure of a radial transfer intravascular blood pump, particularly a foldable blood pump as is known from US 2008/0103591 Al

According to the invention, the clearance between the inner wall of the housing and the impeller is made large enough to handle possible deflection of the housing wall, and the minimum distance is at least 0.2 mm, preferably at least 0.3 mm, more preferably at least 0.4 mm, More preferably at least 0.5 mm, even more preferably 0.6 mm and most preferably at least 1 mm. It has been found that throughput through a radially delivering impeller is sufficient to adequately increase the rotational speed of the drive shaft to compensate for any radial back flow in front of and / or behind the impeller blades. This is not particularly a problem when the axial length of the impeller blades is substantially greater than a clearance, for example, 4 mm or more, preferably at least 5 mm, more preferably at least 6 mm and most preferably at least 7 mm. The power for driving the drive shaft is sufficiently usable because the drive shaft is driven outside the patient.

It is desirable that the aspect ratio (L _rotor / D _rotor ) of the impeller blade in the axial direction (L _rotor ) and the mean rotation diameter (D _rotor ) is equal to or larger than 0.3, Lt; RTI ID = 0.0 > centrifugal < / RTI >

Along the length of the blade, the housing is preferably tapered from a larger diameter at the rear of the housing to a smaller diameter at the front of the housing. This taper plays an important role in separating the inlet pressure from the outlet pressure, thereby reducing blood recirculation from the outlet to the inlet. Taking into account the large clearance between the rotor and the housing wall, the taper is preferably at least 5 degrees, preferably at least 7.5 degrees, more preferably at least 10 degrees, and most preferably at least 12 degrees .

The invention is particularly useful for radial transmission impellers when the space between adjacent blades is opened towards the front wall of the housing. This results in the generation of pressure between adjacent blades by rotation of the impeller which is present adjacent to the front wall, and the front wall of the housing separates the impeller from the low pressure side of the pump. Since the pressure of the blood flow between adjacent blades increases radially outwardly as the impeller rotates, the same pressure increase from the radially inward to the radially outward is present in the vicinity of the front wall. Thus, when the space between adjacent blades is opened towards the front wall, there is no negative radial pressure difference causing significant radial backflow, which is contrary to that proposed in US 2008/0103591 Al.

Therefore, the structure in which the blades are held between spokes (rather than plates) extending axially from the drive shaft is a particularly preferred embodiment according to the present invention. Alternatively, when at least the front plate has a through opening or a perforation for pressure balance towards the front wall of the housing, the blades may be arranged between a front plate radially extending from the drive shaft and, . If the housing further has a rear wall, such through openings or apertures are also provided in the rear plate to provide pressure balance between the rear plate of the impeller and the rear wall of the housing.

Embodiments in which the blades are arranged between spokes extending radially are preferred over embodiments in which the blades are held between the perforated front and rear plates because the spoke configuration is more easily folded about and / It is because. For similar reasons, the blades are preferably of planar construction and may extend in a plane substantially parallel to the axis of rotation.

Essentially, the impeller blades in the blood pump of the present invention swirl the blood around the drive shaft in the housing. That is, due to the blood flow inlet (hereinafter also referred to as " inlet diameter " of the impeller) arranged radially inward with respect to the radially outermost end of the impeller blade adjacent to the drive shaft (hereinafter also referred to as " The centrifugal force acting on the vortex blood forces the blood to flow radially outwardly, allowing additional blood to be drawn through the inlet. The through flow is independent of the size of the gap between the impeller blades and the front and rear walls of the housing. The structure of the blade is not critical if the swirling movement of the blood is high enough to produce the centrifugal force required. The centrifugal force generating the forward flow is directly related to the inlet to outlet diameter. The greater the difference between the inlet diameter of the inlet orifices and the outlet diameter of the impeller blades, the greater the pressure gradient driving the forward flow.

The invention is particularly useful for intravascular foldable blood pumps, but it can also be realized in the form of a non-foldable blood pump and will provide the same effect that the tolerance between the impeller housing and the impeller blade is not critical.

When the housing has a rear wall, the distance between the blade and the rear wall of the housing is preferably within the same range as the distance between the blade and the front wall of the housing. However, when the blade is attached to the drive shaft via a rear plate rather than a spoke, the back plate of the impeller can replace the rear wall of the housing, and the outlet of the blood exiting the housing is located between the back plate of the impeller and the circumferential wall of the housing Can be defined by the gap.

The redirection of blood flow through the housing can be facilitated when the outer diameter of both the housing and the blades in the axial direction from the inlet side to the outlet side increases, suggesting that the blood inlet and outlet are spaced axially and radially do.

The housing itself is preferably made of a non-compliant polymer, preferably polyurethane, which is flexible enough to be folded about the drive shaft but retains a predetermined shape without being folded at high internal pressures do. It is particularly preferred to construct without any frame structure, i.e. the housing is preferably formed substantially only by a non-conforming polymer film.

Embodiments of the present invention will now be described in more detail with reference to the drawings.
BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows a lateral cross-sectional view of a first embodiment of an intravenously injectable, foldable blood pump.
Fig. 2 shows a front view of the impeller of the embodiment shown in Fig.
Figure 3 shows a lateral cross-sectional view of a second embodiment of a blood pump.
Figure 4 shows a lateral cross-sectional view of a third embodiment of a blood pump with an impeller raised in the opposite direction to that shown in Figure 3 and an opposite direction of delivery.
Figure 5 shows a fourth embodiment of a blood pump similar to the embodiment shown in Figure 1 with different shapes of the impeller housing.
Figure 6 shows a fifth embodiment of a blood pump similar to the embodiment shown in Figure 5 with different positions of the impeller.
Fig. 7 shows a first embodiment for inserting a blood pump (of Fig. 3) into a human heart.
Fig. 8 shows a second embodiment of a blood pump in a human heart.
Fig. 9 shows a third embodiment of inserting the blood pump (of Fig. 5) into the patient's heart.
10 is a schematic view illustrating the centrifugal principle.

Figure 1 shows a blood pump according to a first embodiment comprising a long flexible bendable shaft 12 contained in a catheter 14. The catheter 14 is defined by a flexible tube having a diameter of approximately 2.5 mm. The catheter 14 may be made of an abrasion resistant polymer such as polyamide or polyurethane having an abrasion-resistant inner lining of, for example, polyamide or polyimide desirable. The flexible shaft 12 extends through the catheter 14. This axis is typically defined by multiple file wire bundles and may be hollow to accommodate the central guide wire 56 if desired (see the second embodiment shown in FIG. 3). The shaft 12 is driven at its proximal end by a motor (not shown), for example, at 5,000 to 30,000 rpm, while the catheter 14 is held in place. A speed of 30,000 rpm is acceptable for a rotor with a small diameter not exceeding, for example, 7 mm. At the end, i. E. The left end of Figure 1, the shaft 12 includes a rigid portion 16. The distal end of the catheter 14 is connected to the shaft 12 through a sliding bearing 18. The impeller 20 is fastened to the rigid portion 16 of the shaft 12 via a hinge 22 such that the impeller is folded against the shaft 12. The impeller 20, the distal end of the shaft 12 and the catheter 14 are closed by a housing 24 of a bag-like polyurethane skin and thus form an envelope 24 around the impeller 20 . The polyurethane is non-compliant and further permits good connection between the envelope 24 and the catheter 14. The distal end of the envelope 24 includes a hub 26 on which the distal end 28 of the shaft 12 is supported. The shaft can not be axially displaced but is adapted to rotate in the hub 26 so that the envelope 24 is secured against rotation with the rotary shaft 12. [

The envelope 24 includes an annular bulge 30 within the region of the impeller 20, and the impeller rotates in the bulge. The distal end of the envelope 24, including the bulge 30 and the impeller 20, defines the pump head 31. In the distal region of the bulge 30, the envelope 24 comprises a concentric front wall 32 arranged at large spacing between 0.5 and 1 mm from the distal side of the impeller 20. The bulge 30 can be reinforced and stretched by a concentrically arranged elastic polymer or metal bar (not shown in Fig. 1) formed with the desired geometry at deployment. For example, a shape-memory metal, such as Nitinol, previously formed with the desired geometry to match the rotor shape and the desired clearance between the impeller 20 and the envelope 24, Lt; / RTI > The use of a minimum frame structure occupying the minimum space when folded and the increased pressure in the envelope 24 by centrifugal force acting on the blood and enhancing the pressure in the envelope 24 as the impeller 20 rotates It is desirable to depend in part. On the proximal side of the bulge 30, the envelope 24 includes an elongated cylindrical extension 36. In this embodiment, the outer diameter of the cylindrical extension 36 is smaller than the outer diameter of the bulge 30. At the distal and proximal regions of the envelope 24 are provided forward and rearward flow openings 38,40 wherein the forward flow opening 38 is the inlet opening and the rear flow opening 40 is the outlet opening. Between the radially outer end of the impeller 20 and the envelope 24, an annular deflection channel 42 is defined during operation of the blood pump, and the radially delivered blood flows through the deflection channel and is deflected in the axial direction.

The impeller 20 is supported by two substantially parallel support structures 44 and 46 that are permanently connected to the rigid portion 16 of the shaft 12 through the hinge 22 and at a distance greater than, . Each support structure 44, 46 is defined by the six spokes 48 shown in FIG. Thus, the angle between adjacent spokes 48 is approximately 60 degrees. The spokes 48 define the spoke wheels in each case. The spokes 48 of the spoke wheels are identical in size and shape. Between the spokes 48, which are the same size and shape of the two support structures 44, 46, blades 54 of a polymer skin in the form of a sail are arranged.

In a similar embodiment, a small number of spokes such as only two spokes can be arranged, so that a minimum amount of material needs to be compressed when folded while accommodating a rotor design with slightly lower efficiency. Thus, slightly higher rotational speeds (greater than 4,000 rpm) may be required to generate the same amount of eddies.

The impeller 20 rotates partially in the chamber defined by the envelope 24 and partly by the partition wall or the back wall 62. The blood flow inlet opening 38 is formed in the envelope 24 at the distal end of the chamber in which the impeller 20 rotates and the blood flow outlet opening 64 is formed in the rear wall 62. The outlet opening 64 in the rear wall 62 is arranged at a maximum radial distance from the shaft 12 while the blood flow inlet opening 38 is arranged radially close to the shaft 12. [ Due to the centrifugal force acting on the blood as the impeller 20 rotates, blood is drawn through the radially inner inlet opening 38 and the blood flows through the radially outer outlet opening 64 through the rear flow opening 40 And is discharged into the cylindrical extension 36 of the discharging envelope 24.

The size of the envelope 24 relative to the size of the impeller 20 may be on the one hand between the front support structure 44 and the end front wall 32 of the envelope 24 and on the other hand between the back support structure 46 and the partition or post Is selected to have two large gaps (60) between the walls (62). The deflection channel 42 also provides a wide clearance between the radially outer boundary of the impeller 20 and the circumferential wall or bulge 30 of the envelope 24. [ The deflection of the envelope 24 toward the impeller 20 under an external load or internal stress will not cause any contact with the impeller 20.

The gap 60 in front of and behind the support structures 44 and 46 of the impeller 20 is maintained by the elevated pressure as the impeller 20 rotates in the chamber or by the front wall 32 and / Lt; RTI ID = 0.0 > elastic < / RTI > polymer or metal frame structure. Because of the rotational and centrifugal forces of the impeller 20 that act on the blood and force the blood to flow radially inwardly and radially outwardly, the pressure in the chamber also increases radially inwardly and radially outwardly. This pressure acts on both the partition wall or the back wall 62 and the front wall 32 of the envelope so that the gap between the back wall 62 and the envelope (s) 24 are spaced apart from the impeller 20.

3 shows a second embodiment of a blood pump. The guide wire 56 extends through the shaft 12 and the end 58 of the guide wire is of the "J" type and possibly "pigtail" type, May be inserted into the heart through the opening 56. Before operation, the guide wire 56 is removed. Such a guide wire 56 may be used as well in other embodiments described herein.

The second embodiment shown in Fig. 3 is additionally different from the first embodiment shown in Fig. 1 by the construction of the impeller 20, in particular by its front and rear support structures 44, 46. Fig. First, the back support structure 46 is formed from a plate that can be formed by six spokes 48 interconnected by a polymer skin to replace the partition or back wall 62 of the first embodiment shown in Fig. Of the rear plate.

Second, the front support structure 44 is also formed, for example, as a plate in which a polymer skin is mounted between the spokes 48. However, the front support structure 44 has an opening (not shown) that ensures pressure balance from the space between the adjacent blades 54 towards the gap 60 between the front support structure 44 and the front wall 32 of the envelope 24 45). This pressure balance, as described, helps to maintain the width of the gap 60 by pressing the wall of the envelope 24 outwardly and thereby expanding the envelope 24 to its maximum extent.

Third, a plurality of fixed vanes 25 are arranged in the envelope 24 about the catheter 14 from the back support structure 46 to arrest the vortex in the bloodstream and thereby further increase blood pressure. do. The fixed vanes 25 extend along the length of the catheter 14 and their inlet ends are inclined towards the vortex vortex to improve laminar flow without eddying. This fixed vane 25 may also be advantageous in other embodiments described above and below.

4 shows a third embodiment of the blood pump 10 in that the impeller 20 extends from the axis at a negative angle, here approximately -70 degrees, rather than a positive angle, Which is different from the embodiment. Therefore, the blood flows in the opposite direction in the blood pump 10 in comparison with FIG. The pumping action is effective from the proximal end to the distal end. Blood flows into the blood pump 10 through the rear flow opening 40 and leaves the blood pump 10 through the forward flow opening 38. In this embodiment, the narrower portion of the envelope 24 should be radially supported in a stent-like configuration to prevent collapse if the vortex in front of the impeller is not sufficient to maintain the impeller in a radially stable state .

The blood pump 10 described so far has a gap 60 formed between and adjacent the impeller 20 and the size of the envelope 24 and in particular at the end between the impeller 20 and the envelope 24 Except for this, it is substantially the same as the blood pump described in US 2008/0103591 A1. Further details of how the pump 10 is driven, folded and unfolded are described in US 2008/0103591 Al.

A fourth embodiment will now be described with reference to Fig. This embodiment is similar to the first embodiment shown in Fig. 1, except that the envelope 24 has a skirt-like extension 36. Fig. Here, the outer diameter of the bulge 30 is maintained substantially constant so as to form a large rearward flow opening 40 without decreasing proximately from the impeller 20. A blood pump with a skirt-like envelope 24 as shown in FIG. 5 consumes less energy as blood flow does not have to be redirected radially inwardly toward the shaft 12. A short neck portion having a slightly reduced diameter at the proximal end of the skirt-like extension 36 or at the outlet opening 40, however, maintains the inner pressure of the skirt-like envelope 24 above the external pressure, It is also advantageous to prevent fluttering or even collapse of the skirt-like extension 36. Again, the partition or back wall 62 may be provided if the back support structure 46 is formed as a plate as described above for the second embodiment shown in FIG. This may be advantageous because the impeller with the rotating back plate is in contact with the blood immediately downstream of the impeller 20, i. E., In close proximity thereto, thereby inducing blood movement to reduce the risk of thrombosis.

A second difference of the fourth embodiment shown in Fig. 5 in comparison with the previous embodiment is that the impeller 20 has an increasing diameter from the inlet end towards the outlet end. This structure supports blood flow in the desired direction, here from distal to proximal, and provides a maximized emission diameter to increase the delivery rate.

A fifth embodiment is shown in Fig. This embodiment differs from the above-described embodiment by the impeller 20, which is mainly located further away from the blood flow inlet opening 38. This arrangement provides the advantage that the blood flowing through the inlet opening 38 will not have a vortex upon entry into the axial direction, and vortices of blood will be generated in the housing. When the impeller 20 is arranged closer to the blood flow inlet opening 38, the vortex applied to the blood by the impeller 20, as in the previous embodiment, is forced through the inlet opening 38 due to the high viscosity of the blood Will be partially delivered to the blood outside the housing 24. This causes energy loss. As shown in FIG. 6, this arrangement is remote from the entrance opening 38 to prevent such energy loss.

Figures 7-9 illustrate different methods of placing a blood pump in the heart. Fig. 7 shows the blood pump 10 according to the first and second embodiments of Figs. The blood pump 10 is provided with a pump pump 31 in which a pump head 31 including an inlet opening 38 arranged at the end is arranged in the left ventricle LV and a rear pump region Is arranged to be disposed in the aorta (AO) in front of the aortic arch (AOB). The cylindrical extension 36 of the envelope 24 has a length of approximately 60 to 80 mm. The aortic valve (AK) surrounds the cylindrical extension (36). The blood pump 10 delivers blood from the left ventricle (LV) into the aorta AO in the proceeding direction from the distal end to the proximal end. Blood flows into the envelope 24 of the blood pump 10 through the end flow opening 38. The rotating impeller accelerates the blood within the bulge 30 of the envelope 24 and pumps the blood into the cylindrical extension 36 of the envelope 24. The blood exits the blood pump 10 through the proximate flow opening 40.

7 shows a "pigtail" shaped hard tip 26 that helps the blood pump 10 be supported on the myocardium to maintain a minimum distance between the suction area of the blood pump 10 and the inner wall of the myocardium. Fig.

Fig. 8 shows a method of disposing the blood pump 10 arranged in close proximity. The distal end of the blood pump including the flow opening 38 is disposed in the left ventricle (LV) in the heart. A pump head 31 including a bulge 30 including a close flow opening 40 and an impeller 20 is disposed in the aorta AO at the end of the aortic arch (AOB). A catheter 14 including a drive shaft 12 extends through the aortic arch (AOB). In the region of the aortic arch (AOB), the flexible shaft 12 is bent. The aortic valve AK surrounds the cylindrical extension 36 of the blood pump envelope 24, which is arranged upstream, as seen in the direction of delivery. The length of the cylindrical extension 36 is approximately 60 to 80 mm. The blood pump 10 delivers blood from the left ventricle LV to the aorta AO in the same manner as the pump shown in Fig. 6, i.e., from the distal end to the proximal end. The blood enters the cylindrical extension 36 of the blood pump envelope 24 through the end flow opening 38 and the extension 36 is positioned upstream and reinforced radially as compared to the pump shown in Figure 7 And the impeller 20 (not shown) in the bulge 30 of the envelope 24. Inside the aorta AO and in front of the aortic arch (AOB), the accelerated blood flows out through the forward flow opening 40. Here again, an extended end of the inlet opening 38 in the form of a pigtail 58 may be added.

Fig. 9 shows a method of disposing the blood pump 10 according to the fourth embodiment of Fig. The blood pump 10 includes a pump head 31 including a flow opening 38 arranged at the distal end of a skirt-like cylindrical extension (not shown) having a large outflow opening 40 arranged in the left ventricle LV 36 are arranged in the aorta AO in front of the aortic arch (AOB). The cylindrical extension of the envelope 24 has a length of approximately 40 mm to 60 mm. The aortic valve AK surrounds the cylindrical extension 36. The blood pump 10 delivers blood from the left ventricle (LV) to the aorta AO in the proceeding direction from the distal end to the proximal end. Blood flows into the envelope 24 of the blood pump 10 through the end flow opening 38. The rotating impeller accelerates the blood within the bulge 30 of the envelope 24 and pumps the blood into the cylindrical extension 36 of the envelope 24. The blood exits the blood pump 10 through the proximal outlet opening 40.

Fig. 10 shows the principle of the method of generating drive pressure in the centrifugal pump described below. As can be seen in Fig. 1, the radially outermost portion of the inlet opening 38 defines the maximum inner diameter Di, The radially outermost end of the annular groove 54 defines the outer diameter Do. Due to the rotational speed, the velocity applied to the blade 54 and hence the blood produces a pressure difference APmax that can be calculated as follows.

Here, omega is the angular velocity of the shaft 12. The curve shown in Fig. 10 illustrates this principle using an omega constant. Therefore, the pressure difference DELTA pmax roughly corresponds to the blood pressure difference between the inlet opening 38 and the radially outer end of the blade 54 (Fig. 1).

10: Blood pump
12: Axis
14: catheter
20: Impeller
24: housing, envelope
26: Hub
30: Bulge
32: Front barrier
36: Extension
38, 40: opening
42: channel
44, 46: support structure
48: spoke
54: blade
60: Clearance
62: rear barrier

Claims (16)

A blood pump (10) insertable intravascularly,
A rotor having a rotation axis to form a radially delivering impeller 20 and at least one blade 54 arranged about the rotation axis,
A flexible shaft 12 extending through the catheter 14 and configured to drive the rotor,
A housing (24) in which the impeller is arranged for rotation, the housing having a blood flow inlet (38) arranged radially inwardly with respect to the radially outer end of the at least one blade (54) with respect to the axis of rotation - < / RTI >
Wherein the first axial distance between the front wall (32) of the housing (24) and the impeller (20) is 0.3 mm or more. The blood pump (10) according to claim 1, wherein the first axial distance is at least 0.4 mm or more. 3. The blood pump (10) of claim 1 or 2, wherein the housing further comprises a rear wall (62), wherein a second axial distance between the rear wall (62) and the impeller (20) is at least 0.3 mm. The blood pump (10) according to claim 3, wherein the second axial distance is at least 0.4 mm or more. 4. A method according to any one of the preceding claims, wherein the at least one blade (54) and the housing (24) are foldable and unfolded between a first reduced diameter structure and a second increased diameter structure Can Blood Pump (10). A blood pump (10) according to any one of the preceding claims, wherein the blood flow inlet (38) and the blood flow outlet (64) of the housing (24) are axially spaced. 7. The blood pump (10) of claim 6 wherein the outer diameter of the housing (24) and the at least one blade (54) increases axially from the blood flow inlet (38) to the blood flow outlet (64). A blood pump (10) according to any one of the preceding claims, wherein the at least one blade (54) has an axial length of at least 2 mm. A blood pump (10) according to any one of the preceding claims, wherein the at least one blade (54) has a planar configuration. A blood pump (10) according to any one of the preceding claims, wherein the housing (24) is made of a non-compliant polymer. The blood pump (10) according to claim 10, wherein the housing is not a frame structure. 3. A blood pump (10) according to any one of the preceding claims, wherein a space defined between adjacent blades (54) opens toward the front wall (32) of the housing (24). 3. A device according to any one of the preceding claims, wherein the housing (24) comprises at least one stationary vanes (25), the vanes (25) being arranged behind the impeller (20) A blood pump (10) extending along the catheter (14). 4. A device according to any one of the preceding claims, wherein the housing (24) has a skirt-like extension (36) having a neck-like portion of reduced diameter at its outlet end (40) Blood pump (10). 4. The method of any one of the preceding claims, wherein the at least one blade (54) has an aspect ratio of 0.3 or greater and the aspect ratio is defined as L _rotor / D _rotor ,
Wherein the L _rotor is the axial length of the blade (54) and the D _rotor is the average rotational diameter of the blade (54). The blood pump (10) according to any one of claims 1 to 7, wherein the housing (24) is made of polyurethane.

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