KR101912537B1 - Stent for blood clots removal - Google Patents

Abstract

The present invention relates to a stent for blood clot removal. The stent for blood clot removal comprises: a body unit having a cylindrical structure in which both ends are opened in a longitudinal direction, and expended to a blood vessel wall in which a blood clot is placed; and a filter unit coupled to one end in the longitudinal direction of the body unit, and selectively filtering a material moving to one end in the longitudinal direction through the body unit. The filter unit accommodates a fine blood clot left from the blood clot, and is provided for a material smaller than the fine blood clot to pass therethrough.

Description

[0001] STENT FOR BLOOD CLOTS REMOVAL [0002]

The present invention relates to a stent for removing thrombus.

Immediate action immediately after symptom onset of ischemic stroke patients is one of the most dramatic and effective treatments, and the most effective treatment at the beginning is to reopen the occluded blood vessels and normalize the cerebral palsy state.

Much of the cause of stroke is due to small vessel disease, major vascular disease, and cardiac embolism. To date, standard reopening has been largely dependent on systemic thrombolysis using vascular solubilizers.

However, thrombolytic therapy using a thrombolytic agent is a method of injecting a thrombolytic agent through a vein within 4.5 hours of the onset of cerebral infarction. However, it has a merit that it can be easily administered, while it acts on the whole body even outside the cerebral blood vessels, It can cause bleeding of important parts of the body, and it is difficult to immediately check the effect. In addition, patients with acute ischemic stroke patients who were treated with systemic thrombolytic therapy had additional limitations such as a time limit of 4.5 hours after the onset of symptoms, as well as in patients with coagulopathy, intracranial hemorrhage, recent stroke, The rate of thrombolysis is less than 5%.

On the other hand, thrombectomy using a stent for cerebral vascular grafting is considered to be the most effective treatment for patients who can not be treated with thrombolysis or failing, which is the most representative therapy that can complement the shortcomings of thrombolytic therapy.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a view for explaining a problem of a conventional stent used for cerebral blood vessel thrombectomy.

Referring to FIG. 1, a conventional stent used for the removal of cerebral blood vessel thrombus is a stent developed for supporting a coil used for the treatment of cerebral aneurysm, and the problem of stably not recovering (removing) thrombus due to its large cell size There is a problem that untreated thrombosis, which has not been removed due to the flexibility problem of the stent, remains on the vessel wall. In addition, the conventional stent used for the removal of cerebral blood vessel thrombosis can not completely remove fine clots (i.e., fine blood clots) falling from the thrombus in the recovery process, There is a risk that a secondary cerebral infarction may occur.

In addition, since the conventional stent used for the removal of cerebral blood vessel thrombosis has a structure composed of closed cells only, it has a problem in that it is difficult to remove thrombus from a region with severe bending due to complication of complicated cerebral blood vessel structure due to low flexibility, There is a risk of secondary hemorrhage due to damage to the blood vessel wall due to the process of repeatedly removing the thrombus due to lack of power to widen the narrowed blood vessel due to lack of blood.

The background technology of the present application is disclosed in Korean Patent Laid-Open Publication No. 10-2012-0132368.

It is an object of the present invention to provide a stent for removing a blood clot capable of effectively removing fine clots (fine blood clots) falling from a blood clot in the process of collecting (removing) a blood clot .

SUMMARY OF THE INVENTION It is an object of the present invention to provide a stent for removing thrombus which can effectively remove thrombus so that there is no untreated thrombosis that can not be removed due to the problem of flexibility of the stent.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a stent for removing a thrombus, which can effectively remove thrombus in a region with a severe bending due to complicated cerebral blood vessel structure.

The present invention has been made to solve the above-mentioned problems of the prior art, and it is an object of the present invention to provide a stent for stentless blood flow, The present invention provides a stent for removing a blood clot capable of solving the problem of the risk of secondary bleeding.

It is to be understood, however, that the technical scope of the embodiments of the present invention is not limited to the above-described technical problems, and other technical problems may exist.

According to an aspect of the present invention, there is provided a stent for removing a thrombus, the stent having a cylindrical structure having both ends open in the longitudinal direction, the stent including a body extending into a vessel wall in which a thrombus is located; And a filter unit coupled to one end of the body part in the longitudinal direction and selectively filtering the substance moving toward the one end side in the longitudinal direction through the body part, wherein the filter unit receives the fine thrombus separated from the thrombus, And may be provided to pass a small size of material.

In addition, the filter unit may have a filter member having a plurality of nano pores formed therein, and the nanopore may have a size smaller than the size of the micro thrombus.

In addition, the pore size of the filter portion may be one that can be set in manufacturing the filter portion through electrospinning.

In addition, the filter member may have a hollow portion in which the other end in the longitudinal direction is opened and the one end in the longitudinal direction is closed, and a substance moved to the one end side in the longitudinal direction through the body portion, And may be introduced into the hollow portion.

In addition, the filter unit may be provided so as to be expandable corresponding to the expansion of the body part with respect to the blood vessel wall.

The filter unit may be connected to a first extending strut extending from the plurality of cells among the cells formed along the circumferential direction at one end in the longitudinal direction of the body part to one end side in the longitudinal direction.

Further, the stent for removing thrombus according to an embodiment of the present invention includes a plurality of stent disposed on a second extending strut extending from each of a plurality of cells in the circumferential direction at one end in the longitudinal direction of the body, And may further include a marker.

The body portion may include a plurality of first link portions arranged in an oblique line and spaced apart from each other by a predetermined distance, and a plurality of second link portions connecting adjacent first link portions of the plurality of first link portions, A plurality of main cells including a link portion and arranged in a spiral shape; And one or more open cells arranged in a spiral shape adjacent to each other in the longitudinal direction with respect to the plurality of main cells, wherein one main cell of the plurality of main cells is divided into two first cells Wherein a line connecting the vertexes in the left and right direction of the four vertexes formed by the link portion and the two second link portions of the plurality of second link portions in the up, An angle of 45 DEG or less with respect to the longitudinal direction of the stent can be obtained.

The above-described task solution is merely exemplary and should not be construed as limiting the present disclosure. In addition to the exemplary embodiments described above, there may be additional embodiments in the drawings and the detailed description of the invention.

According to an aspect of the present invention, there is provided a hemostasis device comprising: a body part extending to a blood vessel wall where a blood clot is located; and a filter part coupled to one end in the longitudinal direction of the body part and selectively filtering the material moving toward the one longitudinal side through the body part, The present invention provides a stent for removing blood clots that is adapted to receive a small thrombus separating from a thrombus and pass a substance smaller in size than a micro thrombus, It is possible to effectively remove the blood clot, thereby preventing the risk of secondary cerebral infarction by blocking small cerebral blood vessels with different micro-clots.

According to the present invention, it is possible to effectively filter out fine thrombi separated from the thrombus when the thrombus is removed through a filter member having a plurality of nanopores formed in a size smaller than the size of the micro thrombus.

According to the above-described problem solving means of the present invention, the filter portion is provided so as to be expandable corresponding to the expansion of the body portion to the blood vessel wall (in other words, the filter portion and the body portion have an integral structure) .

According to the above-mentioned problem solving means of the present invention, it is possible to effectively remove the thrombus at the site of severe flexion by complicating the complicated cerebral blood vessel structure through the stent for removing thrombus, so that the untreated thrombus does not exist.

However, the effects obtainable here are not limited to the effects as described above, and other effects may exist.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a view for explaining a problem of a conventional stent used for cerebral blood vessel thrombectomy.
2 is a schematic view illustrating a structure in which a stent for removing thrombus according to an embodiment of the present invention is inserted into a blood vessel.
FIG. 3 is a view for explaining a forward hybrid structure in a body portion of a stent for removing thrombus according to an embodiment of the present invention. FIG.
4 is a view for explaining an inverse hybrid structure in a body portion of a stent for removing thrombus according to an embodiment of the present invention.
5A is a view showing the structure of a conventional stent including only a main cell of a closed type.
5B through 5E are views showing various cell structures in a body portion of a stent for removing thrombus according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. It should be understood, however, that the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In the drawings, the same reference numbers are used throughout the specification to refer to the same or like parts.

Throughout this specification, when an element is referred to as being "connected" to another element, it is intended to be understood that it is not only "directly connected" but also "electrically connected" or "indirectly connected" "Is included.

It will be appreciated that throughout the specification it will be understood that when a member is located on another member "top", "top", "under", "bottom" But also the case where there is another member between the two members as well as the case where they are in contact with each other.

Throughout this specification, when an element is referred to as "including " an element, it is understood that the element may include other elements as well, without departing from the other elements unless specifically stated otherwise.

The thrombectomy stent of the present application can be applied, for example, to a coronary stent used for cerebral vascular disease or a coronary artery stent used for the treatment of coronary artery stenosis such as heart attack or cardiac infarction. However, the thrombus-removing stent of the present application is not limited thereto and can be applied to various applications.

FIG. 2 is a schematic view illustrating a structure in which a stent for removing thrombus 100 according to an embodiment of the present invention is inserted into a blood vessel.

Referring to FIG. 2, the stent 100 for removing thrombus according to an embodiment of the present invention may include a body 200 and a filter 300.

The body portion 200 has a cylindrical structure with both ends opened in the longitudinal direction and can expand (expand) to the vessel wall where the thrombus is located. The body portion 200 can be contacted (tightly contacted) with the blood vessel wall as it extends to the blood vessel wall where the blood clot is located. The structure of the body part 200 will be described later in detail.

The filter unit 300 is coupled to one longitudinal end of the body part 200 and can selectively filter the material moving toward the one longitudinal side through the body part 200. The filter unit 300 may be provided to receive micro-thrombi separated from the thrombus and to pass a material of a size smaller than micro thrombus. Here, a substance smaller in size than micro thrombi may mean blood flow.

One end in the longitudinal direction of the body part 200 coupled with the filter part 300 is connected to the front end of the body part 200 inserted first into the blood vessel (i.e., the one end on the forward side with respect to the direction of insertion into the blood vessel) Or may mean the front end corresponding to the blood flow direction (i.e., the one end on the forward direction side with respect to the flow direction of the blood flow).

The present invention can remove (or return into the catheter) main thrombus through the body portion 200 in the stent for removing thrombus 100. At this time, in the process of removing the main thrombus, fine clots, that is, micro thrombosis, can move away from the main thrombus and move along the blood flow direction. Such micro thrombus blocks other small cerebral blood vessels, . ≪ / RTI > The stent 100 for removing thrombus according to an embodiment of the present invention has a structure in which the filter unit 300 is coupled to one end in the longitudinal direction of the body unit 200, The micro-thrombus, which is removed from the thrombus (away from the main thrombus) while moving in the bloodstream, is filtered or filtered through the filter unit 300 to remove the main thrombus, By passing the blood flow through the filter unit 300, not only the main thrombus but also micro thrombosis can be effectively removed.

The filter unit 300 may have a filter member 301 in which a plurality of nano pores are formed. Here, the nanopore can be formed to have a size smaller than the size of the micro thrombus. Through this filter element 301, it is possible to effectively filter the fine thrombus without interfering with the flow of a substance smaller in size than the micro thrombus (for example, blood flow). For example, the filter member 301 has a plurality of nanopores. However, the filter member 301 may have a plurality of micropores.

The pore size (size) of the filter unit 300, specifically, the pore size of the filter member 301 may be one that can be set in manufacturing the filter unit 300 through electrospinning.

Specifically, the filter member 301 of the filter portion 300 can be manufactured to have a plurality of nanofoils through electrospinning. In other words, the filter member 301 can be manufactured by applying electrospinning to the body portion (not shown) of the filter portion 300. The filter member 301 is manufactured by electrospinning so that not only the compression ratio of the filter member 301 can be improved but also the pore size of the filter member 301 can be manufactured by the user in a predetermined size. That is, the pore size of the filter member 301 is freely adjustable (or settable) through electrospinning.

Electrospinning is a process technique that emits liquefied material through a nozzle with a high voltage applied to a substrate or target with a relatively low potential, and uses an electric field to generate a continuous stream having a diameter of micrometer (μm) to nanometer (nm) ≪ / RTI > Since the electrospinning technique is well known to those skilled in the art, a detailed description thereof will be omitted. For example, the filter member 301 can be manufactured by coating a membrane through an electrospinning system to which a gas guided nozzle is applied. In the present invention, the filter member 301 is manufactured through electrospinning. However, the present invention is not limited thereto. Various techniques for manufacturing the filter member 301 having a good compression ratio and having a nanopore can be applied.

In addition, the filter member 301 may have a hollow portion 302 in which the other end in the longitudinal direction is opened and the other end side in the longitudinal direction is closed. Through this, the material moving toward one end in the longitudinal direction through the body part 200 can be introduced into the hollow part 302 through the opened part at the other end in the longitudinal direction. The fine thrombus having a size larger than the pore size of the filter member 301 among the substances introduced into the hollow portion 302 is accommodated (i.e., caught) in the filter member 301, A material such as a blood stream having a size smaller than the pore size of the filter element 301 may flow through the filter element 301. [

The filter unit 300 may be extended to correspond to the expansion of the body 200 with respect to the blood vessel wall. Like the body 200, the filter 300 may expand (expand) into the blood vessel wall and contact (adhere) to the blood vessel wall.

The width of the hollow portion 302 of the filter portion 300 may be set to have the same width as the width of the body portion 200.

The filter unit 300 may be connected to a first extending strut 201 extending from one of a plurality of cells formed along the circumferential direction at one longitudinal end of the body part 200 to one longitudinal end side. For example, when the filter portion 300 is connected to two first extending struts 201, the two first extending struts 201 are struts extending from two points corresponding to the width of the body portion 200 But is not limited thereto. In addition, the number of the first extending struts 201 to which the filter unit 300 is connected may be, for example, two to four, but is not limited thereto and may be variously implemented. In addition, the filter portion 300 may be connected to the second extending strut 202.

The filter unit 300 may be connected to a strut of each of two or more cells among a plurality of cells formed along the circumferential direction at one longitudinal end of the body unit 200. For example, when the filter unit 300 is connected to a strut of each of two cells among a plurality of cells, the two cells may be cells formed at positions facing each other, but the present invention is not limited thereto. For example, the number of the plurality of cells to which the filter unit 300 is connected (or the number of struts corresponding to a plurality of cells) may be two to four, but is not limited thereto and can be variously implemented.

The stent 100 for removing blood vessels according to an embodiment of the present invention includes a body portion 200 and a body portion 200. The body portion 200 includes a body portion 200, And a plurality of markers 400 installed on the display unit 202. For example, the marker 400 may be installed in each of the four second extending struts 202, and the number of the markers 400 may be variously implemented. In addition, the marker 400 may be installed on the first extending strut 201.

The marker 400 may be installed (or provided) for one strut (in other words, for one strut per cell) in each of a plurality of cells formed along the circumferential direction at one longitudinal end of the body 200, .

The marker 400 may be installed at one end of the body 200 to which the filter unit 300 is coupled.

The marker 400 may comprise a radiopaque material (material, material).

For example, metal materials such as magnesium, potassium, calcium, titanium, chromium, iron, cobalt, and nickel may be used as 3-4 periodic atoms in the periodic table in the form of an X-ray (10 to 0.01 nanometers) Meter) can easily penetrate and it may be difficult to identify the position of the stent inserted into the human body. For this purpose, the marker 400 may comprise at least five radiopaque materials of the periodic table, such as platinum, gold, tantalum, tungsten, and thallium. The marker 400 included in the stent 100 for removing thrombus according to one embodiment of the present invention may preferably include a platinum material. However, the marker 400 is not limited thereto, and the marker 400 may include various radiopaque materials. The position of the stent 100 for removing thrombus can be identified by the marker 400.

The position of the filter portion 300 in the blood vessel can be estimated by the marker 400, the first extending strut 301 and the second extending strut 302. [ That is, the position of the filter unit 300 in the blood vessel can be estimated by the distance relationship between the marker 400, the first extending strut 201, and the second extending strut 202.

In addition, the body portion 200 and the filter portion 300 included in the thrombus-removing stent 100 may have a compression structure insertable into the catheter.

A detailed description of the structure of the body part 200 is as follows.

FIG. 3 is a view for explaining a forward hybrid structure in a body portion of a stent for removing thrombus according to an embodiment of the present invention. FIG. 4 is a cross- Fig.

Referring to FIGS. 3 and 4, the body 200 of the stent 100 for removing thrombus according to an embodiment of the present invention may have a cylindrical structure with both ends opened in the longitudinal direction. In addition, a plurality of main cells 10 and a plurality of open cells 20 may be alternately arranged in the body part 200.

The stent 100 for removing thrombus according to an embodiment of the present invention may include a forward hybrid stent for removing thrombus 100 and a stent for removing reverse thrombus in accordance with the position of the open cell 20 in the body 200 100). Hereinafter, the stent 100 for removing thrombus according to one embodiment of the present invention will be referred to as a stent 100 for convenience of explanation.

The main cell 10 is arranged in a spiral shape on the body 200 of the stent 100 and the open cells 20 for increasing the flexibility can be disposed between the main cells 10 arranged in a spiral shape . At this time, one open cell can be arranged for each of two minimum main cells 10, and flexibility of the stent can be improved as the number of the open cells 20 and corresponding main cells 10 increases. At this time, the flexibility of the body part 200 can be controlled by adjusting the number of the main cells.

In addition, the open cells 20 in the body 200 may be arranged in the same direction as the spiral direction in which the main cells 10 are arranged.

Since a plurality of main cells 10 and a plurality of open cells 20 are arranged in a spiral shape in the body portion 200 of the stent 100, the stent 100 has an excellent effect on the flexibility and expansion force required for the stent .

The plurality of main cells 10 may include a plurality of first link portions 11 arranged at a predetermined distance from each other with an oblique line. The plurality of first link portions 11 may be formed by bending to form a sinus curve along the longitudinal direction of the body portion 200 when the body portion 200 of the present stent 100 is inflated . That is, the first link portion 11 can be formed so that the mountains and the valleys are alternately located.

The plurality of main cells 10 may include a plurality of second link portions 12 connected to adjacent first link portions 11 among the plurality of first link portions 11 and arranged at a predetermined distance have.

The plurality of main cells 10 may be arranged in an inclined structure with respect to the longitudinal direction of the main body 200 of the present stent 100, as shown in FIGS. For example, the main cell 10 may be formed to be inclined by 30 to 60 degrees with respect to the longitudinal direction of the body part 200. [

One of the main cells 10 of the plurality of main cells 10 has two opposing first link portions 11 and a plurality of second link portions 12 among the plurality of first link portions 11, And may be formed by the two second link portions 12 facing each other. One main cell 10 may be formed in a slanted rhombus shape.

Meanwhile, one main cell 10 can be formed with four vertexes in the substantially vertical and horizontal directions as the first link part 11 and the second link part 12 are connected to each other. A line (not shown) connecting the vertexes a and b in the left and right direction among the four vertexes may form an angle of 45 degrees or less with respect to the longitudinal direction of the body portion 200. That is, the line s connecting the vertexes a and b of the main cell 10 is preferably positioned in a recapture direction so that recapture is possible.

At least one of the first link portion 11 and the second link portion 12 constituting one main cell 10 may be formed in a wavy shape. At this time, the wave shape may be an alphabet S shape. Illustratively, referring to FIG. 3, the first link portion 11 may be formed in a wavy shape, and the second link portion 12 may be formed in a straight line shape.

For example, the plurality of open cells 20 may be alternately arranged in a spiral shape along the longitudinal direction of the plurality of main cells 10 and the body portion 200. At this time, the open cell 20 may be a single cell formed corresponding to the plurality of main cells 10. That is, the main cell 10 is understood as a concept of a closed cell, and the open cell 10 can be understood as a cell having an area corresponding to a plurality of closed cells arranged in parallel, The concept of the open cell is obvious to those of ordinary skill in the art of stenting, so a more detailed description will be omitted.

As shown in FIGS. 3 to 4, the open cell 20 may be formed to have a relatively longer length and a shorter width than the main cell 10. 3, the open cell 20 has a length in the direction in which the helix advances (11 o'clock to 5 o'clock in FIG. 3), and the width of the open cell 20 corresponds to the width of the helix It can mean.

In other words, the cavity of the open cell 20 may be formed to be smaller than the cavity of the main cell 10. The open cell 20 is formed in a shape having a cavity smaller than that of the main cell 10 so that the flexibility of the conventional stent of the cerebral vessel .

At this time, one open cell 20 of the plurality of open cells 20 may be arranged adjacent to two or more main cells 10 as shown in FIG. 3 to FIG. 3 to 4, one open cell 20 is arranged adjacently to two main cells 10, but the number of main cells 10 is not limited.

On the other hand, when a plurality of open cells 20 are arranged at adjacent positions of the main cell 10, the arranged positions can be variously implemented. That is, the open cell 20 may be arranged at a position adjacent to the second link portion 12 of the main cell 10 as shown in FIG.

More specifically, the plurality of open cells 20 may be arranged adjacent to the second link portion 12 formed in a linear shape as described above. The present stent 100 having such a structure can improve the recapturing function.

In another embodiment, the open cell 20 may be arranged at a position adjacent to the first link portion 11 of the main cell 10 as shown in FIG.

More specifically, the plurality of open cells 20 may be arranged adjacent to the first link portion formed in a wavy shape as described above. The present stent 100 having such a structure can improve flexibility.

Hereinafter, a conventional stent and a stent 100 having a cell structure according to various embodiments of the present invention will be described in comparison.

5A is a view showing a conventional stent comprising only a main cell of a closed type, and FIGS. 5B to 5E are views showing various cell structures in a body 200 of a stent for removing thrombus according to an embodiment of the present invention .

The stent s shown in FIG. 5 (a) shows a conventional stent consisting of only the main cell 10. Since the conventional stent s shown in Fig. 5A is composed only of the closed type main cell 10, the flexibility of the stent 100 is significantly lower than that of the stent 100 of the present invention. Hereinafter, the stent shown in FIG. 5A is defined as a basic type stent.

FIG. 5B is a view showing a part of the body 200 according to an embodiment of the present stent 100, wherein one open cell 20 is arranged in correspondence with two main cells 10. 5b, the open cell 20 may be arranged adjacent to the second link portion 12 of the main cell 10, that is, adjacent to the second link portion 12 have. Hereinafter, the present stent 100 having the cell shape of the body part 200 shown in FIG. 5B is defined as a first forward stent.

FIG. 5C illustrates a portion of the body 200 according to an embodiment of the present stent 100, wherein one open cell 20 is correspondingly arranged in three main cells 10. FIG. The body 200 shown in FIG. 5C is formed such that the open cell 20 is adjacent to the second link 12 of the main cell 10, that is, 2 link portion 12, as shown in Fig. Hereinafter, the present stent 100 having the cell shape of the body part 200 shown in FIG. 5C is defined as a second forward stent.

5D shows a part of the body 200 according to an embodiment of the present stent 100. One open cell 20 is correspondingly arranged in three main cells 10 and an open cell 20 May be arranged so as to be adjacent to the first link portion 11 of the main cell 10, that is, adjacent to the first link portion 11. Hereinafter, the present stent 100 having the cell shape of the body part 200 shown in FIG. 5D is defined as a reverse stent.

5E illustrates a portion of the body 200 according to an embodiment of the present stent 100. One open cell 20 may be correspondingly arranged in three main cells 10, May be similar to that of the body portion 200 shown in FIG. 5D, a plurality of open cells 20 form a continuous spiral shape, and a plurality of main cells 10 are arranged adjacent to the plurality of open cells 20 in a spiral shape While the body portion 200 shown in Figure 5e forms a part of the spiral shape of one open cell 20 and three main cells 10 adjacent to the one open cell 20 There is a difference in shape between the body portion 200 of FIG. 5D and the body portion 200 of FIG. 5E in that a part of the spiral image is formed. In other words, in the embodiment of the body part 200 shown in FIG. 5E, each open cell 20 is formed in a discontinuous state in which it is offset from the open cell 20 adjacent to the longitudinal direction of the body part, The number of openings 20 corresponding to one open cell 20 (three in FIG. 5E) is continuously formed into a spiral shape.

In addition, the stent 100 may be formed by mixing the body structure of the forward stent and the body structure of the reverse stent.

Table 1 shows the performance comparison results of the basic type, the first forward type, the second forward type, and the reverse type stent.

 [Table 1]

As shown in Table 1, the stent 100 having the first forward type, the second forward type, and the reverse type hybrid cell structure according to one embodiment of the present invention is smaller in the radial force than the conventional basic type stent , Flexibility can be improved.

The body portion 200 of the stent 100 can be understood from the following viewpoints.

The body portion 200 of the stent 100 includes an open cell portion including one or more open cells 20 and a main cell portion including a plurality of main cells 10, And arranged alternately along the direction of the axis to provide the cylindrical structure.

5D, the body portion 200 of the stent 100 shown in FIG. 5D includes an open cell portion including one open cell 20 and three main cells 10 ) May be alternately arranged along the direction of generating the spiral.

5D, the plurality of open cells 20 form a spiral shape consisting of only the open cells 20 along the direction of 2:00 to 8:00, A plurality of main cells 10 are arranged in a spiral shape of only the main cell 10 along the direction of 2 to 8 o'clock adjacent to the spiral shape of the plurality of open cells 20 and the longitudinal direction of the stent . ≪ / RTI > 5D, the body 200 of the stent 100 shown in FIG. 5D includes one open cell 20 (open cell portion) and three main cells 10) (main cell portion) may be alternately arranged in a spiral shape.

That is, according to the above-described aspects, the body portion 200 of the present stent 100 can be understood as a form of forming a cylindrical structure by combining two helical shapes (a spiral formed by the main cell and a spiral formed by the open cells) On the other hand, according to the present aspect, the body portion 200 of the present stent 100 can be understood as a form in which a cylindrical structure is formed by only one helical shape in which an open cell and a main cell are combined.

Also, the body part 200 shown in FIG. 5E may also be configured such that the open cell part including one open cell 20 and the main cell part including three main cells 10 are alternately arranged along the spiral generating direction As shown in FIG.

However, as in the embodiment of FIG. 5E, the body part 200 may be provided such that at least a part of the open cell part is discontinuous with the neighboring open cell part along the longitudinal direction of the cylindrical structure. Specifically, in comparison with the embodiment of FIG. 5D, in the case of the body portion 200 of the stent 100 shown in FIG. 5D, the open cell portion is continuously connected along the width direction of the spiral (2: . On the other hand, in the case of the body portion 200 of the stent 100 shown in FIG. 5E, the open cell portions are not continuously connected to each other along the width direction of the helix (at 2:00 to 8:00 on the basis of FIG. 5E) can confirm.

This current view can also be understood through the body portion 200 of the present stent 100 according to the embodiment shown in Figs. 5B to 5C. Specifically, the body part 200 shown in FIG. 5B is formed by alternately arranging one open cell 20 (open cell part) and two main cells 10 (main cell part) along the 2:00 to 8:00 direction The cylindrical structure can be formed through the spiral shape generated in the shape of the cylinder. The body portion 200 shown in FIG. 5C has a configuration in which one open cell 20 (open cell portion) and three main cells 10 (main cell portion) are alternately arranged along the direction of 2 o'clock to 8 o'clock To form a cylindrical structure.

5B to 5E, the main cell unit may include a plurality of main cells arranged in parallel along the width direction of the spiral. Specifically, in FIG. 5B, two main cells are arranged side by side along the spiral width direction (11 to 5 o'clock direction), and three main cells are arranged along the width direction of the helix Main cells are arranged side by side. In the case of Figs. 5D and 5E, three main cells are arranged side by side along the width direction (2 o'clock-8 o'clock direction) of the helix.

Also, the open cell portion may include one or more open cells arranged side by side along the width direction of the helix. Although only one open cell is shown in FIGS. 5B to 5E, a plurality of open cells may be arranged along the width direction of the spiral. However, it is preferable that the number of open cells arranged side by side along the width direction of the helix is set to be smaller than the number of main cells arranged side by side along the width direction of the helix on the concept of the open cell and the main cell (closed cell) .

As described above, the stent 100 can be applied to a cerebrovascular vessel having a complicated and bendy curve because of its excellent flexibility. In addition, a stent structure optimized for cerebral blood vessels capable of recapping for position adjustment during a procedure Lt; / RTI > However, as described above, the application field of the stent of the present application is not limited thereto. For example, the present stent 100 may be applied to coronary artery stents used for the treatment of cardiovascular stenosis such as heart attack or cardiac infarction, as well as stent for cerebral vessels used for cerebrovascular diseases. In addition to the stent for coronary artery and the coronary artery stent described above, the present stent 100 can be applied to various fields related to the stent and similar fields.

In addition, since the body 200 of the present stent 100 has a mixed cell structure in which a main cell and an open cell are mixed, flexibility of the stent 100 is higher than that of a stand composed of a conventional closed cell, It can be applied to blood vessels and it can effectively remove thrombus without thrombosis that is removed when thrombus is removed. Also, the present invention can have a stent structure capable of recapping by placing the line connecting the vertexes in the left and right direction of the main cell in the same direction as the longitudinal direction of the stent. Further, the present invention can improve the flexibility of the stent by realizing the width of the open cell to be relatively shorter than the width of the main cell. In addition, the present invention can improve the flexibility of the stent by increasing the number of main cells corresponding to one open cell.

In this embodiment, since the filter unit 300 is provided at one end of the flexible body 200, it is possible to effectively remove not only the main thrombus but also the fine thrombosis which is released when the main thrombus is removed. In other words, the present invention can adapt to complicated and curved cerebral blood vessels, enlarge the narrowed blood vessels sufficiently to remove the thrombus, filter (filter) the micro-thrombus generated during the thrombus removal process, It is possible to provide a highly elastic and highly conformable stent for removing blood clots optimized for cerebral blood vessels that can solve the cerebral infarction problem.

The present invention relates to a catheter having a nanopore (or microporous) structure capable of filtering fine blood thromboses without interfering with the flow of the blood stream while having a cell structure capable of stably removing the thrombus to retrieve into the catheter, By providing the stent for removing thrombus 100 to which the filter unit 300 is coupled, it is possible to effectively remove the thrombus.

Further, the present invention can be used as a treatment apparatus for treating other blood vessels and non-vascular diseases other than the stent for removing thrombus.

The stent 100 has a hybrid cell structure in which a closed cell and an open cell are combined with each other. The stent 100 is capable of filtering micro-thrombus and has high flexibility, thrombotic force and swelling power, and can be retrieved.

It will be understood by those of ordinary skill in the art that the foregoing description of the embodiments is for illustrative purposes and that those skilled in the art can easily modify the invention without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed in a similar fashion may also be implemented.

The scope of the present invention is defined by the appended claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be interpreted as being included in the scope of the present invention.

100: stent for removing thrombus
200:
300:
400: Marker

Claims (8)

A stent for removing blood clots,
A body portion having a cylindrical structure whose both ends are open in the longitudinal direction and extending to the vessel wall where the thrombus is located;
A filter unit coupled to one end in the longitudinal direction of the body and selectively filtering the material moving toward the one longitudinal side through the body;
A first marker installed on a second extending strut extending from each of a plurality of cells of the cells formed along the circumferential direction at one end in the longitudinal direction of the body portion to one end side in the longitudinal direction; And
And a second marker provided on one end side of the body part,
Wherein the filter unit is provided to receive a fine thrombus separated from the thrombus and to pass a material having a size smaller than the fine thrombus,
Wherein the filter portion is connected to a first extending strut extending from the plurality of cells of the cells formed along the circumferential direction at one longitudinal end of the body portion to one end side in the longitudinal direction,
The first extending strut extending from two points corresponding to the width of the body portion,
Wherein the position of the filter portion in the blood vessel is estimated by at least one of the first marker and the second marker, the second extending strut, and the distance relationship between the first extending struts,
The body portion may include a plurality of first link portions arranged diagonally with a predetermined distance and a plurality of second link portions connecting adjacent first link portions of the plurality of first link portions, A plurality of main cells arranged in a spiral shape; And
And at least one open cell arranged in a spiral shape adjacent to the plurality of main cells in the longitudinal direction,
Wherein one main cell of the plurality of main cells is formed by two first link portions of the plurality of first link portions and two second link portions of the plurality of second link portions, Wherein a line connecting the vertexes in the left and right directions among the four vertexes in the upper, lower, left, and right directions of the main cell forms an angle of 45 DEG or less with respect to the longitudinal direction of the stent. The method according to claim 1,
The filter unit may include a filter member having a plurality of nano pores,
Wherein the nanopore is formed to a size smaller than the size of the micro-thrombus. 3. The method of claim 2,
Wherein the pore size of the filter portion is configurable upon manufacture of the filter portion through electrospinning. 3. The method of claim 2,
Wherein the filter member has a hollow portion whose one end in the longitudinal direction is open and the one end in the longitudinal direction is closed,
Wherein a material moving toward the one longitudinal end side through the body part flows into the hollow part through an open part on the other end side in the longitudinal direction. The method according to claim 1,
Wherein the filter unit is provided so as to be expandable in correspondence with the expansion of the body part with respect to the blood vessel wall. delete delete delete

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