KR101857625B1 - A realistic head model for validation of electrical brain stimulation and manufactureing method thereof - Google Patents
A realistic head model for validation of electrical brain stimulation and manufactureing method thereof Download PDFInfo
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Abstract
The present invention is to verify the accuracy of a computer-based brain stimulation method by fabricating an actual head model (phantom) identical to a computer-based head model. In order to achieve the above object, the present invention proposes a head model that reflects a human head structure according to an embodiment of the present invention. The head model may be produced by dividing the physical or chemical characteristics of the human head into portions that vary greatly.
Description
The present invention relates to a realistic head model for verifying electrical brain stimulation and a method of manufacturing the same. More specifically, the present invention relates to a realistic head model for verifying a computer simulation result of electrical brain stimulation .
Electrical brain stimulation is used as a method of electrically stimulating the brain to treat brain diseases or to improve brain function. There are surgical and non-surgical methods for electrical brain stimulation.
In electrical brain stimulation, the result of stimulation depends on the intensity, position, and brain structure of the stimulus.
In addition, electrical stimulation is given to the brain for treatment. However, if electrical stimulation is given by wrong position or wrong intensity, side effects such as headache, insomnia, dyspnea and amnesia may occur.
In order to minimize the above-mentioned side effects, various studies for safe and effective brain stimulation are under way.
Particularly, the brain stimulation method is the control of the cranial nervous system due to the current flow. To test the response of the brain stimulation, a computer-based brain stimulation method is mainly used.
Computer-based brain stimulation is a computer-based simulation of current flow when electrical stimulation is given to the brain.
The computer-based brain stimulation method constructs a head model similar to the brain structure of a patient and simulates the current flow when electrical stimulation is given to the brain model by reflecting the intensity of the stimulus, the method of stimulation, and the brain structure of the patient .
Such a computer-based brain stimulation method may need to be verified again because it may cause a difference from the actual brain stimulation.
(Patent Document 1) WO2010-116982 A
The present invention is to verify the accuracy of a computer-based brain stimulation method by fabricating an actual head model (phantom) identical to a computer-based head model.
In order to achieve the above object, the present invention proposes a head model that reflects a human head structure according to an embodiment of the present invention.
The head model may be produced by dividing the physical or chemical characteristics of the human head into portions that vary greatly.
For example, the head model can be manufactured by dividing the human head's electrical characteristics into major parts.
In addition, the head model is fabricated using agarose and NaCl mixture, and the electrical characteristics of the human head can be reflected by adjusting the amount of NaCl according to electrical conductivity.
Also, the mixture is prepared by mixing DI water and NaCl for 2 hours or more using a magnetic stir bar, adding a predetermined amount of agarose to the mixed ultra pure water and NaCl, It can be manufactured by using a stirrer or a hot water bath.
Also, the concentration of NaCl in each part of the head model is controlled by a relation of conductivity σ (S / m) = (179) * C + (0.032), where σ is conductivity, C is NaCl Concentration (g / ml).
Also, in the head model, a part where the electrical characteristics of the human head greatly changes can be divided into a brain, a skull, and a scalp.
In addition, the head model may be manufactured by preparing a mold for each of the parts, pouring agarose and a mixture of NaCl into the mold, fabricating the phantom corresponding to the brain, skull and scalp, and assembling .
In addition, the head model may be provided with an assembled structure so that the head model can be assembled with the pedestal portion of the head model under the phantom corresponding to the brain.
According to another embodiment of the present invention, a method of manufacturing a head model reflecting a human head structure is presented.
The manufacturing method may include manufacturing the head model by dividing the head model into portions where electrical characteristics of the human head vary greatly.
Wherein the step of fabricating comprises: forming a mold corresponding to each brain, skull and scalp of the head structure; And assembling the phantom of each of the brain, skull, and scalp using each of the molds.
The head model is fabricated using a mixture of agarose and NaCl, and the electrical characteristics of the human brain can be reflected by adjusting the amount of NaCl according to electrical conductivity.
The mixture was prepared by mixing DI water and NaCl for 2 hours or more using a magnetic stir bar, adding a predetermined amount of agarose to the mixed ultra pure water and NaCl, Or can be produced by using hot water.
The concentration of NaCl in each part of the head model is controlled by a relation of conductivity σ (S / m) = (179) * C + (0.032), where σ is conductivity, C is NaCl concentration g / ml).
According to the configuration of the present invention, a head model having a shape similar to that of a human head can be manufactured and the result of a computer-based brain stimulation simulation can be verified. Thus, a brain stimulation simulation can be performed more accurately before an electric stimulus is actually applied to the brain have.
Those skilled in the art will appreciate that the effects derived from the present invention are not limited to the above description and can be widely accepted.
Figure 1 illustrates a brain, skull and scalp mold made in accordance with one embodiment of the present invention.
Figure 2 illustrates a brain phantom fabricated in accordance with an embodiment of the present invention.
3 shows a head model according to an embodiment of the present invention.
4 shows an assembly example of a head model according to an embodiment of the present invention.
Specific structural and functional descriptions of embodiments of the invention disclosed herein are merely illustrative for purposes of illustrating embodiments of the invention and that the embodiments according to the invention may be embodied in various forms, And should not be interpreted as being limited to the embodiments described in the application.
Since the embodiments according to the present invention can make various changes and have various forms, specific embodiments are illustrated in the drawings and described in detail herein. It should be understood, however, that the embodiments according to the concepts of the present invention are not intended to be limited to any particular mode of disclosure, but rather all variations, equivalents, and alternatives falling within the spirit and scope of the present invention.
The terms first and / or second, primary and / or secondary, etc. may be used to describe various components, but the components should not be limited by these terms. The terms are intended to distinguish one element from another, for example, without departing from the scope of the invention in accordance with the concepts of the present invention, the first element may be termed the second element, The second component may also be referred to as a first component.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as "comprise," "include," "have," and the like, specify that there is a specified feature, number, step, operation, component, section, element, Steps, operations, elements, parts, or combinations thereof, whether or not explicitly described or implied by the accompanying claims.
Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries should be construed as meaning consistent with meaning in the context of the relevant art and are not to be construed as ideal or overly formal in meaning unless expressly defined herein .
Figure 1 illustrates a brain, skull and scalp mold made in accordance with one embodiment of the present invention.
In order to accurately produce a human head model, it is necessary to grasp the human head shape accurately. For this purpose, the shape of the head composed of brain, skull and scalp can be grasped for each patient by using image equipment such as MRI.
The head model may be produced by dividing the physical or chemical characteristics of the human head into portions that vary greatly. For example, it can be produced by differentiating according to the temperature characteristic, electrical characteristic, light scatter characteristic, or mechanical characteristic.
In the following embodiments, the head model is produced by dividing the human head into the parts (brain, skull, and scalp) in which the electrical characteristics of the human head greatly changes. However, the present invention is not limited thereto.
A mold capable of forming each part can be manufactured as a 3D printer, for example, according to the shape of a head identified by using an MRI or the like. In Fig. 1, a mold of a brain, a mold of a skull, and a mold of a scalp made of a 3D printer are disclosed from the left.
A phantom can be created for each part using a mold made from the shape of brain, skull and scalp.
First, we make a brain phantom using a brain mold, assemble the mold of the skull into the phantom of the brain, pour the solution, make the phantom of the skull, and remove the mold of the skull.
Then, the phantom of the scalp can be made by pouring the solution after assembling the mold of the scalp to the phantom of the skull.
Figure 2 illustrates a brain phantom fabricated in accordance with an embodiment of the present invention.
Each phantom is made by pouring the mixture made with agarose and NaCl mixture into each mold.
The electrical properties of each part of the human head can be reflected by adjusting the amount of NaCl according to the electrical conductivity.
The mixture was prepared by mixing DI water and NaCl for 2 hours or more using a magnetic stir bar, adding a predetermined amount of agarose to the mixed ultra pure water and NaCl, Or can be produced by using hot water.
Also, the concentration of NaCl in each part of the head model is controlled by a relation of conductivity σ (S / m) = (179) * C + (0.032), where σ is conductivity, C is NaCl Concentration (g / ml).
In this embodiment, when the agarose mixture is used at a concentration of 1.2%, which is generally used, there is a disadvantage that the agarose mixture is quickly melted. Therefore, agarose at a concentration of 1.2% Os was used.
The head model may be fabricated by preparing a mold for each part and pouring a mixture of agarose and NaCl into the mold to fabricate each phantom corresponding to the brain, skull, and scalp.
3 shows a head model according to an embodiment of the present invention.
Connecting the electrodes to the actual electrical stimulus in the head model and giving electrical impulses can be used to determine how the current flows in the head model and to verify the computer-based simulation by comparing it with a computer-based simulation.
4 shows an assembly example of a head model according to an embodiment of the present invention.
The head model may be provided with an assembled structure so that the head model can be assembled with the pedestal portion of the head model under the phantom corresponding to the brain.
The assembled structure may include a male groove in the lower portion of the brain phantom, and a female groove in the bearing portion of the head model.
In this embodiment, the portion where the electrical conductivity is largely changed is divided into the brain, the skull and the scalp, but the mold can be manufactured by further subdividing each of the brain, skull and scalp.
Claims (14)
In the head model,
Each comprising a plurality of phantoms solidified of NaCl and a predetermined concentration of an agarose mixture,
The phantoms,
The phantoms corresponding to the brain, the skull, and the scalp, which are portions having a large difference in electrical characteristics among the portions constituting the human head,
The NaCl concentration of the mixture comprising each of the phantoms is all different,
Head model reflecting human head structure.
The mixture was prepared by mixing DI water and NaCl for 2 hours or more using a magnetic stir bar, adding a predetermined amount of agarose to the mixed ultra pure water and NaCl, using a magnetic stirring bar A head model that reflects the human head structure, which is produced with a bath.
The concentration of NaCl in each part of the head model is controlled by a relation of conductivity σ (S / m) = (179) * C + (0.032), where σ is conductivity, C is NaCl concentration g / ml), which reflects the human head structure.
The head model is a head model that reflects a human head structure, in which a mold is fabricated for each part and agarose and NaCl mixture are poured into the mold.
Wherein the head model is provided with an assembled structure so that the head model can be assembled with the head portion of the head model at a lower portion of the phantom corresponding to the brain.
Forming molds of portions constituting the head model based on electrical characteristics of the human head;
Injecting NaCl and a predetermined concentration of an agarose mixture into each of the molds; And
And solidifying the injected mixture for each mold to assemble the manufactured phantoms,
The mixture injected for each mold may contain,
Based on the electrical characteristics of the human head, the NaCl concentration of the mixture is different,
A method of manufacturing a head model reflecting human head structure.
Wherein the forming comprises:
And forming molds corresponding to the brain, skull and scalp, respectively, of the head structure.
A method of manufacturing a head model reflecting human head structure.
Wherein assembling the phantoms comprises:
Assembling the phantoms of each of the brain, skull and scalp using each of the molds.
A method of manufacturing a head model reflecting human head structure.
The mixture was prepared by mixing DI water and NaCl for 2 hours or more using a magnetic stir bar, adding a predetermined amount of agarose to the mixed ultra pure water and NaCl, using a magnetic stirring bar A method of manufacturing a head model that reflects a human head structure, which is manufactured with a bath.
The concentration of NaCl in each part of the head model is controlled by a relation of conductivity σ (S / m) = (179) * C + (0.032), where σ is conductivity, C is NaCl concentration 0.0 > g / ml). < / RTI >
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| KR102321009B1 (en) * | 2021-07-06 | 2021-11-03 | 뉴로핏 주식회사 | Method, server and computer program for designing customized headgear for transcranial direct current stimulation |
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| JP2015132510A (en) * | 2014-01-10 | 2015-07-23 | 学校法人産業医科大学 | Coefficient-of-viscosity measuring method, coefficient-of-viscosity measuring apparatus, inspection method, body fluid electrolyte concentration and viscosity inspection system, and food manufacturing apparatus |
| KR101554501B1 (en) * | 2014-05-16 | 2015-09-21 | 주식회사 덴티스 | Human phantom having multi layered structure and test method for physiological signal acquisition and communication status using thereof |
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| JP2015132510A (en) * | 2014-01-10 | 2015-07-23 | 学校法人産業医科大学 | Coefficient-of-viscosity measuring method, coefficient-of-viscosity measuring apparatus, inspection method, body fluid electrolyte concentration and viscosity inspection system, and food manufacturing apparatus |
| KR101554501B1 (en) * | 2014-05-16 | 2015-09-21 | 주식회사 덴티스 | Human phantom having multi layered structure and test method for physiological signal acquisition and communication status using thereof |
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