KR101779837B1 - A device for the measurement of tympanic temperature with non-invasive and zero-heat flux technology - Google Patents

A device for the measurement of tympanic temperature with non-invasive and zero-heat flux technology Download PDF

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KR101779837B1
KR101779837B1 KR1020150056875A KR20150056875A KR101779837B1 KR 101779837 B1 KR101779837 B1 KR 101779837B1 KR 1020150056875 A KR1020150056875 A KR 1020150056875A KR 20150056875 A KR20150056875 A KR 20150056875A KR 101779837 B1 KR101779837 B1 KR 101779837B1
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sensor
temperature
ear canal
eardrum
heat
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KR20160126172A (en
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송국섭
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송국섭
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    • G01K13/002—
    • G01K1/086—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K1/00—Details of thermometers not specially adapted for particular types of thermometer
    • G01K1/16—Special arrangements for conducting heat from the object to the sensitive element
    • G01K1/165—Special arrangements for conducting heat from the object to the sensitive element for application in zero heat flux sensors

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Abstract

More particularly, the present invention relates to a tympanic membrane temperature measuring device which can be used as a portable device using a battery because it is inserted into the external ear canal 90 and is driven with low power.
A first sensor (10) is installed at a predetermined distance from an eardrum to measure a temperature near the eardrum. A second sensor 20 installed at a predetermined distance from the first sensor 10 in the direction of the entrance of the external ear canal 90 (external auditory meatus) to measure the temperature; A heating wire 30 surrounding the second sensor 20 and supplying a heat amount to the second sensor 20; And an MCU (microcircuit unit) 40 for sensing a temperature difference between the first sensor 10 and the second sensor 20 and supplying electricity to the heat ray 30. [

Description

Technical Field [0001] The present invention relates to a non-contact type temperature measurement method using a heat flux zero method,

More particularly, the present invention relates to a device for measuring a temperature of a tympanic membrane, which can be used as a portable device using a battery because it is inserted in an ear canal and driven by a low power, .

The measurement of the core body temperature is an important item for the evaluation of human health and comfort. The international standard ISO 9886 (2004) specifies how to measure the skin temperature and core body temperature of the human body. While skin temperature is easier to measure, deep temperature has been constantly controversial because of its accuracy and continuity, patient annoyance, and health risks.

The oesophageal temperature nearest the heart and the tympanic temperature of the hypothalamus and the artery that are responsible for hyperthermia are considered to be the most reliable data of deep temperature, Because of the inconvenience and risk to health of the subjects during the measurement, they are not used clinically. In order to measure the temperature of the esophagus, it is necessary to insert a sensor into the esophagus. In this process, the patient feels nauseous, which is likely to vomit, and thus the application of the temperature of the tympanic membrane is difficult. In order to alleviate the pain accompanying the sensor, It was difficult to apply.

The rectal temperature of the rectum is easy to measure and can be measured continuously. However, since the time-delay effect responds to environmental or stress changes, , It is estimated that it is not suitable for the experiment. Nonetheless, rectal temperature is the most widely used experimental method in field experiments due to its ease of measurement. Fox et al. (1973) suggested the possibility of measuring deep temperature at the surface of skin. The proposed method is implemented by attaching a first temperature sensor to the surface of the skin, covering the first sensor with the insulator, attaching another second temperature sensor to the surface of the insulator, and placing a heater on the second temperature sensor. The temperature measured by the first temperature sensor attached to the surface of the skin is generally high and the temperature measured by the second temperature sensor located at the atmosphere side is influenced by the environment so that a lower temperature is measured by the first temperature sensor. When two temperature sensors record different temperature values, the heater is turned on and the two temperature sensors continue heating until they reach the same temperature.

Fig. 1 is a conceptual diagram of a deep temperature measurement sensor of a heat flux zero system. In Fig. 1, a thermistor is a sensor for measuring temperature, and a heater is a means for supplying heat so that the temperatures of two thermistors become equal to each other. This measurement method has been named as a zero-heat-flux deep-core thermometer (US Patent Publication No. 2011/0249699).

However, the existing deep temperature zero measuring system developed in the past has a drawback in that it is inconvenient to use AC power because it can not be used in a portable manner due to high power consumption. Therefore, the conventional deep temperature measurement system of the heat flow rate zero system requires equipment such as a large battery when it is required to measure the deep temperature in an outdoor environment without an external power source, And there was a problem such as lack thereof.

U.S. Published Patent Application No. 2011/0249699 U.S. Patent No. 3,933,045

 Togwa, T., Nemoto. T., Yamazaki T. (1976), A modified internal temperature measurenent device. Medical and Biological Engineering and Computing 14 (3), 361-364.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a device for measuring a temperature of a tympanic membrane, which can be used for portable use without reducing the power consumption of the subject without suffering from the pain.

It is another object of the present invention to provide a tympanic membrane temperature measurement apparatus provided with a controller 50 for controlling the temperature of a heater so as to prevent an image of the external ear canal 90 made of sensitive skin when measuring a tympanic membrane temperature.

It is another object of the present invention to provide a tympanic membrane temperature measurement apparatus including means for preventing damage to the ear canal 90 during fixation temperature measurement and fixing the position of the first sensor 10 to the correct position.

It is another object of the present invention to provide an eardrum temperature measuring device having an ergonomic structure that is easy to insert into the external ear canal 90 when measuring eardrum temperature.

Another object of the present invention is to provide a device for measuring a temperature of a tympanic membrane, which can prevent heat loss during tympanic temperature measurement, thereby further reducing power consumption.

Another object of the present invention is to provide a device for measuring the temperature of a tympanic membrane, which can maintain the same pressure in the external auditory canal 90 when measuring the tympanic membrane temperature, thereby eliminating the inconvenience of the subject.

      It is another object of the present invention to provide an apparatus for measuring an eardrum having an appropriate length for preventing eardrum damage during eardrum temperature measurement.

In order to accomplish the above object, the present invention provides a blood pressure monitor comprising: a first sensor (10) spaced apart from a eardrum by a predetermined distance and measuring a temperature in the vicinity of the eardrum; A second sensor 20 installed at a predetermined distance from the first sensor 10 in the direction of the entrance of the external ear canal 90 (external auditory meatus) to measure the temperature; A heating wire 30 surrounding the second sensor 20 and supplying a heat amount to the second sensor 20; And a microcircuit unit (MCU) for sensing a temperature difference between the first sensor 10 and the second sensor 20 to supply electricity to the heat ray 30. The first sensor 10 and the second sensor 20 And the temperature of the second sensor (20) is determined as the core body temperature at the instant when the temperature of the second sensor (20) becomes the same.

Further, the present invention is characterized by further comprising a controller 50 for keeping the temperature of the ear canal 90 below a threshold value of a burn.

 The controller (50) is controlled by a proportional control or proportional integral control method.

The present invention further includes a guide part 60 fixed between the first sensor 10 and the second sensor 20 and having a larger diameter than the first sensor, the second sensor and the heat line 30 . The material of the guide portion may be silicone rubber.

The first sensor 10 is fixed to the center of the silicone rubber 60.

The shape of the silicone rubber 60 is C-shaped, which is opened in the direction opposite to the insertion direction of the tympanic membrane temperature measuring device, and is easily inserted into the external ear canal 90.

Further, the present invention is characterized by further comprising a lid 70 formed of a material having a high heat insulating property and closing the opening of the ear canal 90.

The lid 70 is made of urethane.

The lid 70 is provided with a hole 80 for keeping the air pressure and the external pressure of the inside of the external ear canal 90 the same.

The length of the tympanic membrane temperature measuring device inserted into the external ear canal 90 is shorter than the length from the entrance of the external ear canal 90 to the eardrum.

According to the present invention, the eardrum temperature measuring device has an effect of reducing power consumption and being portable.

Further, the present invention has an effect of preventing the image of the external ear canal 90 by controlling the temperature of the heater when measuring the eardrum temperature.

In addition, the present invention has an effect of preventing the ear canal 90 from being damaged when measuring the eardrum temperature.

In addition, the present invention has an effect of being easily inserted into the ear canal 90 when measuring the eardrum temperature.

Further, the present invention has an effect of preventing heat loss when measuring the eardrum temperature.

The present invention also has the effect of keeping the pressure inside and outside of the external ear canal 90 the same when measuring the eardrum temperature.

In addition, the present invention has an effect of preventing damage to the eardrum when measuring the eardrum temperature.

The above and other objects, features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG.

FIG. 1 is a conceptual view of a deep temperature measurement sensor of a zero-flow zero-flow system. FIG.
Fig. 2 is a view showing a structure of an ear. Fig.
Figure 3 shows the position of the hypothalamus;
4 is a structural view of a tympanic membrane temperature measuring device according to the present invention.
FIG. 5 is a temperature distribution diagram of an ear canal with a tympanic temperature measuring device according to the present invention installed therein.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

It is to be understood that the present invention is not limited to the disclosed embodiments, but may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, It is provided to inform.

FIG. 2 shows a structure of an ear, FIG. 3 shows a position of a hypothalamus, and FIG. 4 shows a structure of a tympanic membrane temperature measuring apparatus according to the present invention.

External auditory canal is formed outside the eardrum. Sound comes through the ear canal and causes the eardrum to vibrate. The carotid artery passes around the eardrum, which is shared with the hypothalamus. The hypothalamus is an organ that regulates the body temperature of the human body. It functions to maintain homeostasis by radiating heat or producing heat by vasodilation, sweating, vasoconstriction, tremor, or the like. The temperature of the tympanic membrane indicates the internal temperature of the hypothalamus of the brain.

Accordingly, it is an object of the present invention to provide a method capable of measuring the deep portion temperature from the eardrum in a non-contact manner by specifying the object to be measured with the eardrum as the eardrum and a device implementing the same.

On average, the length of the auditory canal 90 between the eardrum and the ear canal is about 25 mm, although there is a difference depending on the person and age. The conventional method for measuring the temperature of the eardrum is very painful because it proceeds in contact with the eardrum in a contact manner. In the present invention, the length from the first sensor 10 inserted into the ear canal 90 to the lid 70 is 20 mm Respectively. Therefore, the first sensor 10 does not directly contact the eardrum.

In the conventional eardrum temperature measurement method, the temperature was measured by contacting the temperature sensor with the eardrum. At this time, the subject suffered severe pain and anesthesia was required. In severe cases, it could damage the eardrum. Therefore, the conventional tympanic temperature measuring device has been used in animal experiments occasionally and is rarely applied to the human body. In the present invention, since the sensor is not in direct contact with the eardrum, there is no pain and the risk of damage to the eardrum is reduced.

There may be differences in the length of the ear canal for each individual. Therefore, in the present invention, it is preferable that the position of the cover is adjustable in the tympanic membrane temperature measuring device. For this purpose, in the present invention, a male screw portion 105 is formed around the outer surface of the proximal end portion of the body 100 inserted into the ear canal, and the male screw portion 75 of the lid 70 is fastened to the male screw portion 105. Therefore, by adjusting the position of the lid by rotating the lid 70 with respect to the body 100, it is possible to cope with the difference in the length of the ear canal, which may differ from person to person.

As shown in Fig. 4, the tympanic membrane temperature measuring device of the present invention is inserted into the external ear canal 90 where the tympanic membrane 95 is located. In the insertion, the body 100 of the tympanic membrane temperature measuring device is inserted into the external ear canal, and the lid 70 at the proximal end of the body covers the external ear canal so that the inside of the external ear canal is shielded from the outside by the lid 70.

When resting, the temperature at which the homeostasis is maintained is about 37 ° C. This temperature rises to 38-39 ° C when you exercise, which is not harmful to your health as the temperature control function is within range. However, if the core temperature is below 28 ° C, serious heart arrhythmias will occur and die. And deep temperature above 46 ° C causes irreparable brain damage (ASHRAE, 1997). In a typical environment, the temperature of the atmosphere is lower than the deep temperature of 37 ° C. The heat is then transferred from the high temperature core to the skin and into the atmosphere.

The apparatus for measuring the temperature of a tympanic membrane of the present invention comprises a first sensor (10) which is spaced apart from a tympanic membrane in a state of being inserted in an ear canal and measures the temperature in the vicinity of the tympanic membrane. It is preferred that the first sensor 10 is not in contact with the eardrum but is located close to the eardrum. The first sensor 10 is installed at the distal end of the body 100, which is a plastic tube, and is installed such that the measurement sensor portion is exposed to the outside of the front end of the body 100, as shown in FIG.

Next, the present invention further includes a second sensor 20 which is installed at a predetermined distance from the first sensor 10 in the direction of the entrance of the external ear canal 90 (external auditory meatus) to measure the temperature. The second sensor 20 is installed inside the hollow body 100. The measurement sensor portion of the second sensor is located inside the body 100 and is isolated from the first sensor 10 based on the member constituting the body 100.

Next, a heat ray 30 is installed around the body 100, on which the second sensor 20 is disposed, in a manner to surround the body 100. The heat line 30 is configured to supply heat to the second sensor 20 so that heat is generated in the internal space of the external auditory canal so that the temperature of the deep part of the eardrum and the temperature of the internal space of the ear canal Supply.

Next, a silicone rubber 60 is provided around the body 100 between the first sensor 10 and the site where the hot wire 30 is installed. The silicone rubber 60 has a function of preventing the heat generated in the heat ray 30 from directly affecting the first sensor 10 and also preventing the outer circumference of the silicone rubber 60 from being deformed by the inner peripheral surface of the ear canal 90 So that the surface of the external ear canal is prevented from being scratched and wound on the eardrum temperature measuring device, so that the first sensor 10 and the second sensor 10 are separated from each other, 2 sensor 20 maintains the central position of the ear canal as it is, thereby minimizing the occurrence of errors in the heart temperature measurement.

The apparatus for measuring a membrane temperature of the present invention may further comprise a microcircuit unit (40) for sensing the temperature difference between the first sensor (10) and the second sensor (20) . 5A, when the temperature measured by the second sensor 20 is lower than the temperature of the first sensor 10, the MCU 40 supplies heat to the heat line 30 to measure the temperature of the external auditory canal 30 So that the temperature measured by the second sensor 20 becomes equal to the temperature measured by the first sensor 10. On the other hand, when the temperature of the second sensor 20 is higher than that of the first sensor 10 as shown in FIG. 5C, the heat is supplied excessively, so the electricity supplied to the hot wire is immediately blocked, . Thus, the MCU 40 determines the temperature at the instant when the temperatures of the first sensor 10 and the second sensor 20 become equal to the core body temperature.

The temperature of the tympanic membrane indicates the temperature of the hypothalamus of the brain, which is the highest temperature source in the natural state. Therefore, in the natural state column of the eardrum and heat is transferred to the atmosphere along the ear canal 90, the temperature near the first sensor 10 and the ear drum (T 1) the temperature of the second sensor (20) (T 2) ≪ / RTI > That is, in this state, the temperatures measured by the first sensor 10 and the second sensor 20 are both lower than the temperature T H of the eardrum, as shown in FIG. 5 (a).

When a temperature difference between the first sensor 10 and the second sensor 20 is sensed by a microcircuit unit (MCU) 40, electricity is supplied to the hot wire 30. The controller CTL controls the amount of heat supplied through the hot wire 30 so that the temperature of the first sensor 10 and the temperature of the second sensor 20 become the same. The controller controls the amount of heat supplied to the heating wire 30 so that the temperature of the ear canal 90 is kept at 42 ° C or lower which is the threshold value of the image and when the temperature of the second sensor 20 is higher than the temperature of the first sensor 10, (PI) or proportional derivative integral control (PID) so as to be equal to the temperature of the exhaust gas.

The amount of power to be supplied through PI (proportional and integral) control can be calculated as follows.

Figure 112015039346724-pat00001

here

u (T): control signal, control signal (current or voltage, power)

K p : proportional gain, 1 / PB, PB is the proportional band.

e (T): t set - t a ; error, measured temperature difference between sensor 1 and sensor 2.

T i : integral action time (s), integral execution time.

It is recommended that the temperature difference between the first sensor 10 and the second sensor 20 be within ± 0.1 ° C because the accuracy of the deep portion temperature is recommended to be within ± 0.1 ° C in ISO 9886 (2004) The amount of heat supplied through the heat line 30 is controlled. If the temperatures of the first sensor 10 and the second sensor 20 are the same, the heat flux becomes zero. Therefore, the temperature at this time becomes the temperature of the eardrum, and this temperature becomes a high-level deep temperature representative value.

Since the auditory canal 90 has a small volume of air, it has a small heat capacity, so that the target eardrum temperature can be measured even with a small power. Conventional devices for measuring deep temperature on the forehead or abdomen require a large amount of heat due to the large heat capacity of the skull and complex internal organs, and the battery powered portable devices have had to use an AC power source because of insufficient power. Therefore, it was difficult to measure during the movement and limited use in fixed position. The apparatus for measuring the temperature of the tympanic membrane of the present invention is inserted into the external ear canal 90 to heat only a fixed air layer, not a skull or internal organs, so that the target temperature can be reached with a small amount of heat, It can be used as a portable device during the movement. It is possible to measure even when the metabolism volume changes due to outdoor activity experiment or movement.

To this end, the cover 70 of the present invention is formed of a material having good heat insulation performance such as urethane, by blocking the earhole 80, thereby minimizing heat loss by the heater. In addition, a hole (80) of less than about 1 mm is formed in the lid to allow fine air flow so that the air pressure of the ear canal (90) is maintained at the same level as the atmospheric pressure, The inconvenience can be solved.

As described above, the first sensor, the second sensor, and the silicone rubber 60 having a diameter larger than that of the heat ray 30 are fixed between the first sensor 10 and the second sensor 20. The silicone rubber 60 supports the measuring device in the ear canal 90 so that the measuring device is inserted without causing injury to the external ear canal 90 when the eardrum 90 is inserted into the ear canal 90, (10) is positioned to be close to the center of the eardrum, and serves to support the heat ray from directly touching the inner skin of the ear canal. The shape of the silicone rubber 60 is a C-shape opened in a direction opposite to the insertion direction of the tympanic membrane temperature measuring device, so that insertion into the external ear canal 90 is facilitated.

Hereinafter, the operation of the eardrum temperature measuring apparatus of the present invention will be described.

First, the depth of the subject's ear canal to be measured is roughly grasped. Then, the cover 70 is rotated with respect to the body 100 to adjust the position of the lid 70, thereby adjusting the depth of the first sensor 10 at the tip to be inserted into the ear canal.

Carefully insert the body 100 into the ear canal. At this time, the soft silicone rubber 60 comes in contact with the skin of the external auditory canal so that the body 100 directly touches the skin even when the external body is in contact with the skin, so that the examinee does not feel discomfort or foreign body sensation. The insertion is performed until the lid 70 covers the auricle.

After the lid 70 is covered with the auricle, the first sensor 10, which is closer to the heat source than the second sensor 20, takes a short time to receive a little more heat and then turns on the power to measure the temperature.

First, the measured temperature of the first sensor 10 is measured to be higher than that of the second sensor 20 by the heat flux as shown in FIG. 5 (a). At this time, when the MCU supplies power to the heating wire 30 with the PI or PID control described above, heat is generated in the heating wire and the second sensor side temperature T 2 rises. When the heat ray 30 is heated, the temperature T 2 of the second sensor 20 installed in the body of the plastic tube is increased. When the temperature of the second sensor 20 is equal to the temperature T 1 of the first sensor 10 . When the temperatures of the second sensor 20 and the first sensor 10 become equal to each other, the first sensor 10 converges to the temperature of the eardrum and eventually converges to the eardrum, the first sensor 10, the second sensor 20 (Fig. 5 (b)). This temperature is the deep temperature to be obtained using the eardrum temperature sensor, i.e., the eardrum temperature.

If the supply of heat through the hot wire becomes excessive and the state shown in FIG. 5 (c) is reached, the MCU immediately stops supplying heat through the hot wire to the state shown in FIG. 5 (b).

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the scope of the invention is not limited to the disclosed exemplary embodiments. It is obvious that a transformation can be made. Although the embodiments of the present invention have been described in detail above, the effects of the present invention are not explicitly described and described, but it is needless to say that the effects that can be predicted by the configurations should also be recognized.

10: first sensor
20: second sensor
30: Heat line
40: microcircuit unit (MCU)
50: Controller
60: Silicone rubber
70: Cover
75: Female threads
80: hole
90: Ear canal
95: eardrum
100: Body
105: male threads

Claims (11)

An elongated body 100 having a hollow interior and inserted into the ear canal 90 to measure the eardrum temperature;
A first sensor 10 installed in a state exposed to the outside of the front end of the body 100 to measure a temperature of the eardrum at a distance from the eardrum at a distance from the eardrum at a predetermined distance,
The first sensor 10 is separated from the first sensor 10 by a predetermined distance in the entrance direction of the external ear canal 90 by being installed inside the hollow of the body 100, A second sensor (20) installed and measuring the temperature;
A heating wire 30 for supplying a quantity of heat to the second sensor 20 and surrounding the body 100 around the body 100 where the second sensor 20 is located;
The inner diameter portion is connected to the body and the outer diameter portion is larger in diameter than the heat wire 30 so that the outer edge of the outer diameter portion is connected to the body, A guide portion 60 of a flexible material which is brought into close contact with an inner wall of the body to guide the insertion of the body and prevents the heat generated from the heat line from affecting the first sensor;
A cover 70 installed on the body, the cover 70 being positioned along the longitudinal direction of the body and blocking the entrance of the ear canal 90 to block the air inside the ear canal 90 and the outside air; And
And an MCU (microcircuit unit) 40 for detecting a temperature difference between the first sensor and the second sensor and supplying electricity to the hot wire,
The first sensor 10 measures the temperature of the first space in the ear canal defined by the eardrum and the inner wall of the ear canal and the guide portion,
The second sensor 20 measures the temperature of the second space in the ear canal, which is defined by the guide part, the inner wall of the ear canal and the lid,
Wherein the temperature at the moment when the temperatures of the first sensor and the second sensor become equal to each other is determined as the core body temperature.
The method according to claim 1,
Further comprising a controller (50) for keeping the temperature of the ear canal (90) below a threshold value of a burn.
The method of claim 2,
Wherein the controller (50) is controlled by proportional control or proportional integral control.
delete The method according to claim 1,
Wherein the body (100) is located at a central portion of the guide portion (60).
The method of claim 5,
Wherein the shape of the guide portion (60) is a C-shaped opening in a direction opposite to the insertion direction of the tympanic membrane temperature measuring device, and the insertion is easy to be performed with the external ear canal (90).
The method according to claim 1,
Wherein the lid (70) is formed of a material having a high thermal insulation property.
The method according to claim 1,
Characterized in that the material of the lid (70) is urethane.
The method according to claim 1,
Wherein the cover (70) is provided with a hole (80) for keeping the air pressure and the external pressure of the inside of the external ear canal (90) the same.
The method according to claim 1,
The outer periphery of the proximal end of the body 100 is formed of a male thread 105 and the lid 70 is formed with a female thread to rotate the lid 70 against the body 100, Wherein the position of the eardrum is adjustable.
The method according to any one of claims 1 to 3,
Wherein the length of the tympanic membrane temperature measuring device inserted into the external ear canal 90 is shorter than the length from the entrance of the external ear canal 90 to the tympanic membrane.
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KR20210143457A (en) 2020-05-20 2021-11-29 싱크브레인 주식회사 Optical integrated capsule type photodynamic therapy device
KR20210143963A (en) 2020-05-20 2021-11-30 싱크브레인 주식회사 Optical integrated patch-type photodynamic therapy device

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KR20200061579A (en) 2018-11-26 2020-06-03 재단법인 오송첨단의료산업진흥재단 Core body temperature thermometer having an air pocket
KR20200061580A (en) 2018-11-26 2020-06-03 재단법인 오송첨단의료산업진흥재단 Core body temperature thermometer having a protruded thermistor
KR20200061581A (en) 2018-11-26 2020-06-03 재단법인 오송첨단의료산업진흥재단 Core body temperature thermometer having an air pocket
WO2020111289A1 (en) 2018-11-26 2020-06-04 재단법인 오송첨단의료산업진흥재단 Core-body temperature measurement device having thermistor-protruding structure
WO2020111293A1 (en) 2018-11-26 2020-06-04 재단법인 오송첨단의료산업진흥재단 Core body temperature measurement device having battery charging structure
KR20210143457A (en) 2020-05-20 2021-11-29 싱크브레인 주식회사 Optical integrated capsule type photodynamic therapy device
KR20210143963A (en) 2020-05-20 2021-11-30 싱크브레인 주식회사 Optical integrated patch-type photodynamic therapy device

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