KR101766268B1

KR101766268B1 - Breathing synchronized signal obtain device for breathing synchronized delivery

Info

Publication number: KR101766268B1
Application number: KR1020150057406A
Authority: KR
Inventors: 한우석; 박영환
Original assignee: 한우석; 사회복지법인 삼성생명공익재단
Priority date: 2015-04-23
Filing date: 2015-04-23
Publication date: 2017-08-08
Also published as: KR20160126398A

Abstract

A respiration synchronization signal acquisition apparatus for respiration-synchrotron radiation therapy is disclosed.
The present invention relates to a luminescent patch attached to a human body and arranged so that a plurality of point light sources form apexes of a polygon; A camera for photographing the movement of the luminescent patch in real time; And acquiring a plurality of point light sources from the image captured by the camera, measuring a distance between the extracted point light sources, comparing the extracted distance with the actual distance between the point light sources, and acquiring the three-dimensional coordinates of the light- And a predicted trajectory signal generator for generating a trajectory curve of three dimensions and analyzing the trajectory curve to generate a predicted trajectory curve in real time and generating a predicted trajectory signal, Lt; / RTI >

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a breathing synchronization signal acquisition apparatus for respiration-

The present invention relates to an apparatus for acquiring a respiration synchronization signal for respiration synchronous radiation therapy.

Recently, radiotherapy methods have been improved in combination with computer and networking, radiation therapy treatment planning software, and medical imaging techniques. Such medical imaging techniques include, for example, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography ("PET" : positron emission tomography). In some cases, techniques have been used to plan and deliver radiation therapy.

For example, a method of treating a moving target, such as a tumor in the lung, requires that only when the moving target enters a specified window in the trajectory, quot; gating ", i.e. delivering radiation. However, this method is not efficient because irradiation of the target with irradiation is performed only at periodic time intervals.

Another way to treat moving targets is by breathing synchronized delivery ("BSD"). This technique uses the expected track or path of motion that the target will follow during the course of treatment.

To do this, plan to assume that the target is staying on the anticipated track, and include the anticipated period and phase in the anticipated path through the entire course of the treatment plan. Using voice and video guidance, the patient can be made to follow strict and limited pathways.

The survival rate of patients with lung cancer was 21.9%, which was lower than the survival rate of 60.9%. The low survival rate of patients with lung cancer may be various, but poor radiotherapy is considered to be an important factor.

The reason for poor radiotherapy results in lung cancer is that the entire surface area of the organ due to respiration is treated with radiation, which increases the irradiation side of the radiation and increases the possibility of side effects. To solve these problems, a real-time tracking system is under development.

Gating Therapy is used as Real-time Position Management (RPM) to reduce the scope of investigation by quantifying the respiratory synchronization applied to the treatment of lung cancer patients.

Conventionally, a breathing signal acquisition method using an expensive infrared camera has been used. However, since a camera for infrared ray imaging has a large size, when the position of the patient is non-coplanar in a radiation treatment apparatus, Had limitations.

The present invention is to provide a breathing synchronization signal acquisition device for enabling breathing signal acquisition using a general camera.

A related prior art document is Korean Patent Laid-Open Publication No. 10-2008-0039919 (published on May 7, 2008) entitled " System and Method for Detecting Respiratory Condition of Patients Receiving Radiotherapy ".

It is an object of the present invention to provide a respiration synchronization signal acquisition device which can photograph a state of a patient in real time and acquire a respiration synchronization signal to predict a motion of a treatment part.

It is another object of the present invention to provide a breathing synchronization signal acquisition apparatus capable of acquiring three-dimensional motion of a patient using a luminescent patch and a general camera.

The present invention relates to a luminescent patch attached to a human body and arranged so that a plurality of point light sources form apexes of a polygon; A camera for photographing the movement of the luminescent patch in real time; And acquiring a plurality of point light sources from the image captured by the camera, measuring a distance between the extracted point light sources, comparing the extracted distance with the actual distance between the point light sources, and acquiring the three-dimensional coordinates of the light- And a predicted trajectory signal generator for generating a trajectory curve of three dimensions and analyzing the trajectory curve to generate a predicted trajectory curve in real time and generating a predicted trajectory signal, Lt; / RTI >

The predicted locus signal generator may transmit the generated predicted locus signal to the radiotherapy apparatus in real time.

Wherein the light emitting patch includes a patch body having a mounting surface attached to the measurement target portion and a tracking surface connected to the mounting surface, and a light emitting portion having one end fixed to the tracking surface, An optical fiber, and a light source for supplying light to the optical fiber.

Preferably, the predicted trajectory signal generating unit generates a predicted trajectory signal of the surface of the mounting surface.

The tracking surface may be angularly connected to the attachment surface.

It is further preferable that the light source unit is capable of adjusting the light emission illuminance.

When a plurality of patch bodies are provided, the plurality of patch bodies may be connected to one light source unit.

The respiration synchronization signal acquisition apparatus according to the present invention can acquire the point light source of the light source patch with the camera by using the light source patch, thereby improving the accuracy of the acquired information.

Further, the breathing synchronization signal acquisition apparatus according to the present invention can detect the movement of the human body three-dimensionally, thereby obtaining a more accurate breathing synchronization signal.

In addition, the respiration-tuned signal acquisition apparatus according to the present invention may separately form a light source unit to prevent the light source unit from interfering with the radiation treatment during the radiation therapy, thereby realizing tracking in real time.

FIG. 1 is a block diagram of a respiration synchronous signal acquisition apparatus for respiration-synchronous radiation therapy according to an embodiment of the present invention.
2 is a flowchart illustrating a method of generating a predicted locus signal of a predicted locus signal generator according to an exemplary embodiment of the present invention.
3 is a perspective view showing a first embodiment of a luminescent patch according to the present invention.
4 is a perspective view showing a second embodiment of the luminescent patch according to the present invention.
5 is a perspective view showing a third embodiment of the luminescent patch according to the present invention.
6 is a perspective view showing a fourth embodiment of the luminescent patch according to the present invention.
7 and 8 are use state diagrams showing a camera arrangement of a breathing synchronization signal acquisition apparatus according to the present invention.

The terms and words used in the present specification and claims should not be construed as limited to ordinary or preliminary meaning and the inventor shall properly define the concept of the term in order to describe its invention in the best possible way It should be construed in accordance with the meaning and concept consistent with the technical idea of the present invention. It should be noted that the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention and do not represent all the technical ideas of the present invention, It should be understood that various equivalents and modifications are possible.

FIG. 1 is a block diagram of a respiration synchronous signal acquisition apparatus for respiration-synchronous radiation therapy according to an embodiment of the present invention.

As shown in the figure, an apparatus for acquiring a respiration synchronous signal for respiration synchronous radiation therapy according to an embodiment of the present invention includes a light emitting patch 100 having a plurality of point light sources, And a predicted locus signal generator 300 for generating a predicted locus signal from the image acquired by the camera 200. [

The predicted locus signal generator 300 transmits the predicted locus signal to the radiotherapy apparatus 500 in real time, and the radiation therapy apparatus 500 can irradiate the treatment region with the predicted locus signal.

The luminescent patch 100 is attached to a body part that changes according to the patient's breathing and is capable of tracking the movement of the patient in accordance with the breathing. A plurality of point light sources are arranged to form vertices of polygons have.

A polygon is formed by a point light source, and the camera recognizes the point light sources, thereby accurately tracking the three-dimensional position of the light emission patch 100 with respect to the camera 200. [

At this time, the polygon can be a square or more polygons.

The camera 200 captures the motion of the luminescent patch 100 in a real-time image, and a general camera that captures an image with light in a visible light region can be applied.

Conventionally, an infrared camera is used to acquire an image, and a reflector is attached to the measurement target portion to track the movement of the reflector. However, this structure is limited in that the angle of view of the reflector and the infrared camera is limited and the infrared camera is expensive there was. The present invention includes a luminescent patch (100) to photograph light emitted from the luminescent patch (100) with a general camera, thereby solving the problem of limitation of the angle of view due to the size of the infrared camera.

The expected trajectory signal generation unit 300 extracts a point light source from the moving image of the light emission patch 100 acquired by the camera 200 and calculates the distance between the extracted point light sources and the distance between the actual point light sources, Dimensional trajectory curve, generates a predicted trajectory curve from the generated trajectory curve in real time, and transmits the predicted trajectory curve to the radiation therapy apparatus 500. [

2 is a flowchart illustrating a method of generating a predicted locus signal of a predicted locus signal generator according to an exemplary embodiment of the present invention.

As shown, the predicted locus signal generation includes an image processing step S20, a locus curve generation step S22, and a predicted locus derivation step S24.

The image processing step S20 is a step of extracting a point light source from a frame of an image acquired by the camera 200. [

The trajectory curve generation step S22 calculates the distance between the point light sources extracted in the image processing step S20 and the distance between the point light sources in the actual light emission patch 100 to determine the three- And accumulating the changes of the three-dimensional position to generate a three-dimensional trajectory curve.

The expected trajectory deriving step S24 is a step of deriving an expected trajectory from the generated three-dimensional trajectory curve. The future trajectory can be derived by functioning the trajectory in such a manner that the generated three-dimensional trajectory curve is expressed by infinite or finite Fourier expansion.

Trajectory Curve The light expected trajectory is preferably generated for the point of contact with the light emitting patch and the human body. The luminescent patch of the present invention is for measuring the movement of the human body, and it is desirable that the portion contacting the human body leads to a predicted locus for a specific point on the attachment surface of the luminescent patch. For example, it is desirable to derive an expected trajectory for the face center of the attachment surface.

3 is a perspective view showing a first embodiment of a luminescent patch according to the present invention.

As shown in the figure, the light emission patch for acquiring the respiration tuning signal according to the present invention includes a patch body 110 having an attachment surface 112, a tracking surface 114, and a point light source on the tracking surface 114 And a light source unit 130 for supplying light to the optical fiber 120. [

The patch body 110 adheres to the measurement target portion and is attached to the chest or abdomen of the patient. The attachment surface 112 of the patch body 110 is preferably formed such that an adhesive layer can be formed and attached to the skin of the patient. The attachment surface 112 may be formed using a double-sided tape or the like. When the patch body 110 is formed in a plate shape, one surface may be the attachment surface 112 and the other surface may be the tracing surface.

In the tracking surface 114, the end of the optical fiber is exposed and light is emitted from the optical fiber. This structure is for allowing the optical fiber to emit light to the point light source on the tracking surface 114 so that the point light source can be identified in the image by using the camera 200. [

Preferably, the patch body 110 is formed of a nonmetallic material in which the radiation irradiated during the treatment of the wire is not spoiled.

In particular, in the case of the tracking surface 114, it is preferable that the surface is matte treated. A recognition error or a recognition error of a point light source that is emitted from the tracking surface 114 due to reflection of light or the like around the tracking surface 114 does not occur. The matte treatment may be carried out by imparting roughness to the surface or coating with a matte coating.

The optical fiber 120 serves to emit light emitted from the light source unit 130 to the point light source on the tracking surface 114 of the patch body 110. Also, the optical fiber 120 preferably has a length capable of disposing the light source unit 130 at a position spaced apart from the body of the therapist.

The light source unit 130 must include metal parts. If the light source unit 130 is located at a position where the light source unit 130 interferes with the body of the therapist, it may interfere with the radiation treatment.

An optical fiber 120 is connected to the light source unit 130 and includes a light source 132 for supplying light to the end 124 of the optical fiber 120. As the light source 132, various lamps or LEDs that emit visible light may be used. Further, it is preferable that the light source 132 is capable of controlling the light emission illuminance. The brightness of the light emitted from the point light source may be different from that of the camera due to the distance between the camera and the tracking surface 114. In this case, So that the point light source of the light source can be more accurately recognized.

4 is a perspective view showing a second embodiment of the luminescent patch according to the present invention.

In the first embodiment, the attachment surface 112 and the tracking surface 114 are formed in parallel. The second embodiment shows a configuration in which the tracking surface 114 is formed in an erected form with an angle to the mounting surface 112. [

In the second embodiment, the attachment surface 112 and the tracking surface 114 are connected. It is preferable to dispose the camera on the upper side of the patient when the track surface is formed in parallel with the patient's body as in the first embodiment. In the case of the second embodiment, it is preferable to dispose the camera on the side of the patient.

5 is a perspective view illustrating a luminescent patch for acquiring a breathing tuning signal according to a third embodiment of the present invention.

The present embodiment is characterized in that the angle between the attachment surface 112 of the patch body 110 and the tracking surface 114 is adjustable.

As shown, the angle of the tracking surface 114 with respect to the mounting surface 112 can be adjusted by connecting the mounting surface 112 and the tracking surface 114 with the hinge axis 116. This is so that the angle of the mounting surface 112 can be adjusted so that the camera can more accurately recognize the mounting surface 112.

6 is a perspective view showing a fourth embodiment of the luminescent patch according to the present invention.

In this embodiment, a plurality of patch bodies 110 are connected to one light source unit 130. A plurality of patch bodies 110 may be attached to a single light source unit 130 to track movement of various parts of a patient's body. In this case, a plurality of patch bodies 110 may be connected to a single light source unit 130.

7 and 8 are use state diagrams showing a camera arrangement of a breathing synchronization signal acquisition apparatus according to the present invention.

The camera 200 can be disposed at a proper position so as to more accurately acquire the motion image of the point light source of the luminescent patch. 7, when the tracking surface of the luminescent patch 100 is parallel to the patient's body, the camera 200 can be disposed above the patient.

8, the camera 200 may be disposed above the head of the patient so as to arrange the camera 200 closer to the luminescent patch 100. [

It is to be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive, and the scope of the present invention will be indicated by the appended claims rather than by the foregoing detailed description. It is intended that all changes and modifications that come within the meaning and range of equivalency of the claims, as well as any equivalents thereof, be within the scope of the present invention.

100: Luminescent patch
110: Patch body
112: Mounting surface
114: Tracking surface
116: Hinge shaft
120: Optical fiber
130:
132: Light source
200: camera
300: predicted locus signal generator
500: Therapeutic device

Claims

A luminescent patch attached to a human body and arranged so that a plurality of point light sources form apexes of a polygon;
A camera for photographing the movement of the luminescent patch in real time; And
Dimensional coordinates of the light emitting patch with respect to the camera are obtained by comparing the extracted distance between the point light sources with the actual distance between the point light sources, Dimensional trajectory curve, analyzing the trajectory curve to generate a predicted trajectory curve in real time, and generating a predicted trajectory signal,
The light-
A patch body having a mounting surface attached to the measurement target portion and a tracking surface connected to the mounting surface; an optical fiber having one end fixed to the tracking surface and emitting light as a point light source on the tracking surface; And a light source unit for supplying light to the optical fiber,
The surface of the tracking surface is provided with a roughness on the surface of the tracking surface or is coated with a matte coating on the surface of the tracking surface,
Wherein the light source unit is capable of adjusting the light emission illuminance.

The method according to claim 1,
Wherein the predicted trajectory signal generator transmits the predicted trajectory signal to the radiotherapy apparatus in real time.

delete

The method according to claim 1,
The predicted locus signal generator
And generates a predicted trajectory signal of the face punch of the attachment surface.

The method according to claim 1,
Wherein the tracking surface is angularly connected to the attachment surface. &Lt; RTI ID = 0.0 > 8. < / RTI >

delete

The method according to claim 1,
A plurality of patch bodies are provided,
Wherein the plurality of patch bodies are connected to one light source unit.