KR101749324B1 - 3d scattering radiation imager and radiation medical apparatus - Google Patents

3d scattering radiation imager and radiation medical apparatus Download PDF

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KR101749324B1
KR101749324B1 KR1020150180745A KR20150180745A KR101749324B1 KR 101749324 B1 KR101749324 B1 KR 101749324B1 KR 1020150180745 A KR1020150180745 A KR 1020150180745A KR 20150180745 A KR20150180745 A KR 20150180745A KR 101749324 B1 KR101749324 B1 KR 101749324B1
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radiation
detector
energy
detecting
unit
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Korean (ko)
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이원호
이태웅
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고려대학교 산학협력단
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Priority to US16/063,469 priority patent/US20180368786A1/en
Priority to PCT/KR2016/014278 priority patent/WO2017105024A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4241—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using energy resolving detectors, e.g. photon counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/46—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient
    • A61B6/461—Displaying means of special interest
    • A61B6/466—Displaying means of special interest adapted to display 3D data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/482—Diagnostic techniques involving multiple energy imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/542—Control of apparatus or devices for radiation diagnosis involving control of exposure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/547—Control of apparatus or devices for radiation diagnosis involving tracking of position of the device or parts of the device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/01—Devices for producing movement of radiation source during therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring

Abstract

The present invention relates to a three-dimensional scattering radiation imaging apparatus capable of reconstructing radiation information that is scattered in the human body and treated as noise in the course of radiation therapy, and can identify the radiation irradiation position and the dose distribution using the reconstructed image, and a radiation medical apparatus . A three-dimensional scattering radiation imaging apparatus of the present invention comprises a first detector for detecting the position and energy of radiation radiated from a radiation source and scattered from a target object, a second detector for detecting the position and energy of the radiation passing through the first detector, A third detector for detecting the position and energy of the radiation passing through the second detector, and a third detector for detecting the position and energy of the radiation detected by the first detector, the second detector and the third detector, A signal processing unit for obtaining the position of the radiation source in a back tracking manner, and an image processing unit for receiving the information from the signal processing unit and displaying the image as an image. The three-dimensional scattering radiation imaging apparatus according to the present invention can detect the irradiation position and the dose distribution of the radiation in real time by the detection method using the multiple scattering technique during the radiation treatment.

Description

TECHNICAL FIELD [0001] The present invention relates to a 3D scattering radiation imaging apparatus and a radiation medical apparatus having the same,

The present invention relates to a radiation imaging apparatus, and more particularly, to a radiation imaging apparatus that reconstructs radiation information that is scattered in the human body during radiation therapy and treats the radiation as noise, Scatter radiation imaging apparatus and radiation medical apparatus having the same.

Recently, as the quality of life has improved, the importance of the advanced medical device industry is increasing. Among them, the image diagnostic device is a high-tech high value-added industry that accounts for more than 70% of the whole medical device market.

Imaging diagnostic technology is a technology that extracts, processes, analyzes, manages and outputs data essential for the diagnosis and treatment of diseases by quantitatively imaging information on structures, functions, metabolism and components of the organs, tissues, cells and molecules of the human body . The high-resolution biomedical imaging technology according to recent technology development is a convergence type technology such as IT, BT and NT. It is a next-generation core that enables diagnoses of diseases that are difficult to accurately diagnose by existing technologies and early diagnosis before diseases are fully manifested Technology.

Imaging devices include X-ray equipment, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Diagnostic Ultrasound Scanner, Positron Emission Tomography : PET). Radiographic imaging devices include X-ray equipment, computed tomography, and positron emission tomography.

These diagnostic imaging devices can show the tumor noninvasively and enable physicians to access the surrounding tissues whether they are invading or not. This image-based examination is an essential part of modern diagnostic medicine. In addition, the development of computer hardware and software technology capable of high - speed computation makes it possible to make a diagnosis using three - dimensional image rather than a simple two - dimensional image. In recent years, Various diagnostic analysis methods are being developed with high resolution and solidification trend.

On the other hand, the irradiation position and the dose distribution, which are generally irradiated during the radiation treatment, are calculated by computerized prediction in the radiation irradiation planning stage or by putting a phantom similar to water or human body into the glass dosimeter or ion chamber and measuring the experimental value do.

However, these predictive computational simulations and preliminary experiments may be different from the actual irradiation environment and there is uncertainty about them. Also, even in a similar environment, there is a limit to the accuracy of prediction due to the change of the actual measured values. Since the film or the EPID is located on the opposite side of the direction of the incident radiation from the patient based on the measurement method during the irradiation but the resolution of the image is poor and it should be positioned on the radiation direction of the radiation, It can be predicted only by enemy.

Korean Patent Laid-Open Publication No. 2001-0097505 (November 11, 2001) Korean Patent Laid-Open Publication No. 2015-0091812 (Aug. 12, 2015) Korean Patent Registration No. 1527939 (Jun. 10, 2015)

SUMMARY OF THE INVENTION The present invention has been made in order to solve the problems of the prior art as described above, and it is an object of the present invention to provide a radiographic image capturing apparatus, Dimensional scattering radiation imaging apparatus capable of 3D measurement of the irradiation position and the dose distribution of the radiation source and the radiation medical apparatus having the same.

According to an aspect of the present invention, there is provided a three-dimensional scattering radiation imaging apparatus including a first detector for detecting the position and energy of radiation radiated from a radiation source and scattered from a target object, A third detector for detecting the position and energy of the radiation passing through the second detector, and a third detector for detecting the position and energy of the radiation detected by the first detector, the second detector and the third detector, A signal processing unit for receiving the information about the energy and tracking the incidence direction of the radiation to obtain the position of the radiation source; and an image processing unit for receiving the information from the signal processing unit and displaying the information as an image.

The three-dimensional scattering radiation imaging apparatus of the present invention may be configured such that the first detector, the second detector, and the third detector each have a complementary camera structure including a scintillator and an optical sensor.

The three-dimensional scattering radiation imaging apparatus of the present invention may have a compact camera structure in which the first detector, the second detector, and the third detector each include a semiconductor material selected from CdTe, CZT, and TlBr.

According to another aspect of the present invention, there is provided a radiation medical apparatus including a radiation irradiating unit for irradiating a subject with radiation, a radiation detecting unit, and a controller for controlling the radiation detecting unit and the radiation detecting unit Wherein the radiation detection unit comprises a detector for detecting the position and energy of the radiation radiated from the radiation irradiation unit and scattered from the target object, and information on the position and energy of the radiation detected by the detector, A signal processing unit for obtaining the position of the radiation irradiation unit in a manner that tracks the direction of the radiation irradiation unit; and an image processing unit for receiving the information from the signal processing unit and representing the position as an image.

The radiological medical equipment of the present invention may further include a driver for moving the irradiation unit, and the radiation detection unit may detect the radiation while being coupled with the irradiation unit and moving with the irradiation unit .

The radiation medical apparatus of the present invention may further comprise an irradiation unit driver for moving the irradiation unit and a detection unit driver for moving the radiation detection unit.

The plurality of radiation detection units may be spaced apart from each other.

Wherein the detector of the radiation detection unit comprises a first detector for detecting the position and energy of the radiation irradiated from the radiation irradiation unit and scattered from the object, a second detector for detecting the position and energy of the radiation passing through the first detector, Detector and a third detector for detecting the position and energy of the radiation passing through the second detector.

The radiation detection unit may be a compact camera whose detector is provided with a scintillator and an optical sensor.

The radiation detection unit may be a compact camera whose detector comprises a semiconductor material selected from the group consisting of CdTe, CZT, and TlBr.

The radiation detection unit may further comprise a focusing unit for focusing the scattered radiation in the object and sending the scattered radiation to the detector.

The radiation medical device of the present invention may further include a CT detector coupled with the radiation detection unit to reconstruct a three-dimensional image.

The radiation medical apparatus having the above-described three-dimensional scattering radiation imaging apparatus according to the present invention can measure radiation in real time during treatment beyond the prediction using a conventional test body or computer simulation, The 3D distribution of the irradiated radiation can be obtained. Moreover, since results can be obtained without additional dose studies, better treatment observations are possible with existing radiation medical devices.

In addition, the three-dimensional scattering radiation imaging apparatus according to the present invention is installed in a form fused with a radiation medical instrument, thereby detecting the irradiation position and the dose distribution of the radiation in real time by using the multi-scattering detection method during the radiation treatment using the radiation medical equipment can do.

1 is a schematic view of a radiation medical device having a three-dimensional scattering radiation imaging apparatus according to an embodiment of the present invention.
Fig. 2 is a block diagram showing a main configuration of the radiation medical instrument shown in Fig. 1. Fig.
3 schematically shows the configuration of the three-dimensional scattering radiation imaging apparatus shown in FIG.
4 shows an outline and formula of the radiation compton scattering.
FIG. 5 is a view for explaining a method of detecting the position of a radiation source using the three-dimensional scattering radiation imaging apparatus shown in FIG.
6 to 8 show various modifications of the three-dimensional scattering radiation imaging apparatus shown in FIG.
9 and 10 show various modifications of a radiation medical device having a three-dimensional scattering radiation imaging apparatus according to the present invention.

Hereinafter, a three-dimensional scattering radiation imaging apparatus and a radiation medical apparatus having the same according to the present invention will be described with reference to the drawings.

FIG. 1 is a schematic view of a radiation medical apparatus having a three-dimensional scattering radiation imaging apparatus according to an embodiment of the present invention, FIG. 2 is a block diagram showing a main configuration of a radiation medical apparatus shown in FIG. 1, Dimensional scattering radiation imaging apparatus shown in FIG.

1 to 3, a radiation medical apparatus 100 having a three-dimensional scattering radiation imaging apparatus according to an embodiment of the present invention includes a radiation irradiation unit 110 for irradiating radiation, A three-dimensional scattering radiation imaging apparatus 130 for detecting a dose distribution, and a controller 140 for controlling the radiation irradiation unit 110 and the three-dimensional scattering radiation imaging apparatus 130. The radiation medical device 100 according to the present invention includes a three-dimensional scattering radiation imaging device 130 capable of detecting a more accurate radiation irradiation position and a dose distribution in real time, thereby realizing a real-time irradiation position and a dose distribution In addition, it is possible to solve the problem that the radiation direction and the direction of the detector must coincide with each other in the measurement method, thereby eliminating the error due to the uncertainty in the actual treatment environment. The radiation medical device 100 according to the present invention can be applied to various radiation medical devices such as LINAC and tomotherapy equipment.

The irradiation unit 110 is moved by the driver 120 to irradiate the patient P while rotating 360 degrees around the patient P. [ The irradiation unit 110 and the driving unit 120 are controlled by the controller 140.

The three-dimensional scattering radiation imaging apparatus 130 is integrally coupled to the irradiation unit 110. The three-dimensional scattering radiation imaging apparatus 130 moves with the radiation irradiation unit 110 by the driver 120 to measure the radiation scattered from the patient P in real time while rotating around the patient P by 360 degrees. The three-dimensional scattering radiation imaging apparatus 130 includes a radiation detection unit 131 of a compton camera structure for detecting radiation by an electronic focusing method.

As is known, compton cameras are radiation imaging devices that image the three-dimensional distribution of radiation sources using the principle of compound scattering. The compton camera includes a scatterer and an absorber detector, and obtains the direction information of the incident photon using the energy measured from the scatterer and the absorber and the detected position information. That is, the photon can be detected from the detection position of the scattering part and the absorption part by the locus of the photon traveling from the scattering part to the absorption part after the scattering of scattered light, and an axis connecting the locus can be generated. Also, since the scattering angle can be calculated from the energy measured at the scattering portion, it can be seen that the photon is incident at the scattering angle around the generated axis. However, since the angle of incidence is unknown, it can be assumed that the photon was emitted at a point on the surface of the cone with half angle of scatter angle. In principle, if there are only three such cones, it is possible to obtain the intersection point of these cones and to infer the in-situ emitted photons in the three-dimensional space. Such a compact camera uses an electronic collection system that estimates the position of the radiation source using only the detected position and energy information measured by the detector without a mechanical focusing device, thereby detecting a single photon using a mechanical focusing device It is possible to overcome various limitations of existing nuclear medicine imaging, nondestructive testing and radiation imaging devices for space radiation measurement.

The radiation detection unit 131 of the three-dimensional scattering radiation imaging apparatus 130 includes a plurality of detectors 132, 133 and 134, a signal processing unit 138 and an image processing unit 139. Referring to FIGS. 3 and 5, the plurality of detectors 132, 133, and 134 are spaced apart from each other. These detectors 132, 133 and 134 have the same structure, and detect the position and energy of the radiation scattered from the subject to be irradiated, such as the patient P. The plurality of detectors 132, 133 and 134 each include a scintillator 135, an optical sensor 136, and an electronic circuit 137. Here, as the optical sensor 136, PSPMT, SiPM, or the like may be used. The first detector 132 detects the position and energy of the radiation irradiated from the radiation source irradiation unit 110 and scattered from the patient P. [ The second detector 133 detects the position and the energy of the radiation passing through the first detector 132 and the third detector 134 detects the position and the energy of the radiation passing through the second detector 133. The signal processing unit 138 receives the information on the position and the energy of the radiation from the plurality of detectors 132, 133 and 134, and calculates the position of the radiation source in such a manner as to track back the incident direction of the radiation. The image processor 139 receives information from the signal processor 138 and displays the image.

The three-dimensional scattering radiation imaging apparatus 130 having the radiation detecting unit 131 of the compton camera structure is configured so that the first detector 132 and the second detector 133 of the radiation detecting unit 131 continuously detect Scattering occurs, and the radiation is absorbed by the third detector 134 or compton reaction occurs. At this time, the position information and energy information of the radiation incident from the first to third detectors 132, 133, and 134 are acquired, and the acquired information is transferred to the signal processing unit 138. The signal processing unit 138 obtains information on the position and type of the radiation source from the information received from the detectors 132, 133 and 134, and the image processing unit 139 receives the information from the signal processing unit 138 Image.

The three-dimensional scattering radiation imaging apparatus 130 of the radiological medical instrument according to the present embodiment can obtain the position of the radiation source in different ways when the direction of the radiation irradiated from the radiation irradiation unit 110 is known or not .

First, the case of knowing the direction of the radiation irradiated from the irradiation unit 110 will be described with reference to Figs. 1 to 4. Fig. Fig. 4 is a schematic diagram of the complex scattering of radiation. Knowing the direction of the radiation incident on the patient P from the irradiation unit 110 and knowing the placement angle of the detectors 132, 133 and 134 of the radiation detection unit 131, the scattered angle of the radiation and the energy hv 'absorbed by the radiation detection unit 131 can be known, so that the energy hv of the original radiation can be obtained using the following equation.

Figure 112015123772282-pat00001

Where hv is the energy of the scattered photons, θ is the scattering angle, and m0c2 is the stationary mass of the electron. Therefore, if the energy hv 'absorbed in the radiation detection unit 131 and the original energy hv can be known, the energy E absorbed in the patient P can be derived from the following equation.

Figure 112015123772282-pat00002

In Equation (1), the expression of the scattering angle expressed by the energy of the incident light and the energy of the scattered light is rearranged as follows.

Figure 112015123772282-pat00003

Substituting this into equation (2), the following energy-related equation can be derived.

Figure 112015123772282-pat00004

Equation (3) is a mathematical expression representing the energy absorbed in the patient by the energy of the scattering light and the scattering angle by integrating Equations (1) and (2).

When the direction of the radiation irradiated from the irradiation unit 110 is unknown, the energy and direction of the scattering radiation scattered in the patient P and incident on the radiation detection unit 131 are detected, and the theoretical, computational simulation, The radiation dose to be irradiated to the patient P can be measured.

The three-dimensional scattering radiation imaging apparatus 130 of the radiation medical device according to the present embodiment can obtain the energy of the radiation incident on the radiation detection unit 131 without the total absorption of the scattered radiation from the patient P, A concrete method will be described with reference to FIG.

In the arrangement of the detectors 132, 133 and 134 of the radiation detecting unit 131 as shown in Fig. 5, the following equations can be obtained.

Figure 112015123772282-pat00005

Figure 112015123772282-pat00006

Figure 112015123772282-pat00007

Figure 112015123772282-pat00008

Here, r1, r2 and r3 are the radiation detection positions in the detectors 132, 133 and 134, and E1, E2 and E3 are the radiation detection positions in the detectors 132, 133 and 134, Information DE1 and DE2 are the energy absorbed by the first detector 132 and the second detector 133,? 1 and? 2 are scattering angles, and m0c2 is the stop mass of the electron.

The energy E1 scattered from the patient and incident on the first detector 132 through the above equations can be obtained without absorbing the total energy.

In the detection of the position of the radiation source, the scattering angle of the actual radiation is not determined by the detection of the scattered radiation once, but is ascertained through the commonly estimated scattering position when detecting a plurality of scattering lines. That is, in the case of the Compton image, one cone (ring) is formed, and the place where the actual radiation comes in is one of such cones. Therefore, it is judged that radiation comes in where the multiple reactions overlap and are commonly designated.

In addition, the position where the radiation is scattered in the patient P can be recorded three-dimensionally and can be made into a total four-dimensional matrix including the absorbed energy. If the commonly-estimated scattering position mentioned above is determined, if the angle at which the radiation is incident on the patient is calculated, the energy absorbed by the patient is calculated and if the incident angle is not known, It can be done through previous simulations.

As can be seen from the foregoing description, the irradiation direction of the radiation and the angle and position of the detectors 132, 133 and 134 are very important. The controller 140 can organically link the position information of the radiation irradiating unit 110 and the detectors 132, 133 and 134 of the radiation detecting unit 131 to transmit and control the position between them, . That is, the irradiation of the radiation is started by a control signal from the controller 140 when both the irradiation unit 110 and the radiation detection unit 131 are fixed in the planned position, and the obtained signals are detected by the radiation detection unit 131 to the controller 140.

More specifically, the radiological medical device is controlled in the following manner. First, the driver 120 operates according to the position and angle input to the controller 140 to position the radiation irradiation unit 110 and the radiation detection unit 131. An operation signal is transmitted from the controller 140 to the radiation detection unit 131 and the radiation irradiation unit 110 after the placement positions of the radiation irradiation unit 110 and the radiation detection unit 131 are confirmed. The controller 140 sends a radiation stop signal to the radiation irradiating unit 110 after a predetermined time and sends a signal acquisition stop signal to the radiation detecting unit 131. [ After the controller 140 performs the signal processing obtained from the radiation detection unit 131, the driver 120 is operated to irradiate the next irradiation with the radiation irradiation unit 110 and the radiation detection unit 131 to the set positions .

As described above, the radiological medical instrument 100 equipped with the three-dimensional scattering radiation imaging apparatus according to the present embodiment is configured such that the radiation scattered from the patient P is transmitted to the first detector 132 of the three-dimensional scattering radiation imaging apparatus 130 The incident direction of the radiation can be traced back by using the radiation detection position and the energy information of the first detector 132 and the second detector 133 have. Also, when the radiation is scattered in the second detector 133 and scattered or absorbed in the third detector 134, the position information and the energy information in the first to third detectors 132, 133 and 134 are used The incident direction of the radiation can be traced back and the image can be acquired without energy information of the scattering radiation. Further, by knowing the energy and direction of the scattering radiation scattered from the patient P and incident on the radiation detection unit 131, energy information of each incident radiation can be known, and from this, Precise measurement is possible.

The radiation medical apparatus 100 including the three-dimensional scattering radiation imaging apparatus according to the present embodiment may be configured such that the three-dimensional scattering radiation imaging apparatus 130 is coupled to a radiation irradiation unit 110 that is moved by a driver 120, It is possible to measure in real time the radiation scattered from the patient P while the treatment for the patient P is being performed while rotating 360 degrees around the patient P together with the unit 110. [

In addition, the radiological medical instrument 100 equipped with the three-dimensional scattering radiation imaging apparatus according to the present embodiment can measure radiation in real time during treatment beyond the prediction using a conventional test body or computer simulation, The 3D distribution of the irradiated radiation can be obtained. Moreover, since results can be obtained without additional dose studies, better treatment observations are possible with existing radiation medical devices.

The efficiency of the radiation detecting unit 131 constituting the three-dimensional scattering radiation imaging apparatus 130 is determined by the kind (atomic number, density) of the substances constituting the detectors 132, 133 and 134, 132) 133 (134). The spatial resolution is determined by the ratio of the position resolution of the detectors 132,133 and 134 itself to the distance between the detectors 132,133 and 134 and the ratio of the detectors 132,133, Energy resolution. The precise position and energy distribution of the irradiation radiation can be measured by arranging the detectors 132, 133 and 134 in a geometrical structure in which the uncertainty is minimized and by using the scintillator 135 or the semiconductor material excellent in energy resolution have.

6 to 8 show various modifications of the three-dimensional scattering radiation imaging apparatus according to the present invention.

The three-dimensional scattering radiation imaging apparatus 150 shown in FIG. 6 has a radiation detection unit 151 of a compton camera structure for detecting radiation by an electronic focusing method. The radiation detection unit 151 includes a plurality of detectors 152, 153 and 154, a signal processing unit 157 and an image processing unit 158. The plurality of detectors 152, 153, and 154 are installed to be spaced apart from each other. These detectors 152, 153 and 154 have the same structure and detect the position and the energy of the radiation scattered from the subject to be irradiated such as the patient P and the like. The plurality of detectors 152, 153, and 154 each include a semiconductor material 155 and an electronic circuit 156. The first detector 152 detects the position and the energy of the radiation that is irradiated from the radiation source irradiation unit 110 (see FIG. 1) and scattered from the patient P. The second detector 153 detects the position and energy of the radiation passing through the first detector 152 and the third detector 154 detects the position and the energy of the radiation passing through the second detector 153. The signal processing unit 157 receives the information on the position and the energy of the radiation from the plurality of detectors 152, 153 and 154, and calculates the position of the radiation source in such a manner as to track back the incident direction of the radiation. The image processing unit 158 receives information from the signal processing unit 157 and displays the image.

Here, as the semiconductor material 155, CdTe, CZT, TlBr, or the like may be used. Detectors 152, 153, and 154 using such semiconductor material 155 are capable of detecting radiation using an output pulse without the need for an optical sensor. Output pulses of each of the detectors 152, 153 and 154 are provided to the signal processing unit 157 and processed. The processed signal is again supplied to the image processing unit 158 and converted into an image.

The three-dimensional scattering radiation imaging apparatus 160 shown in FIG. 7 has a radiation detection unit 161 that detects radiation by a mechanical focusing method. The radiation detection unit 161 includes a main body 162, a detector 163, a signal processing unit 167, and an image processing unit 168. The concentrator 162 is a means for geometrically limiting and detecting the radiation having a desired direction, and various types can be used depending on the detection site and purpose. The concentrator 162 may be a parallel hole concentrator, a pinhole concentrator, URA, MURA, HURA, or the like. The detector 163 detects the position and the energy of the radiation scattered from the irradiation target object such as the patient P or the like. The detector 163 includes a scintillator 164, an optical sensor 165, and an electronic circuit 166. As the optical sensor 165, PSPMT, SiPM, or the like can be used. The signal processing unit 167 receives the information on the position and the energy of the radiation from the detector 163, and calculates the position of the radiation source in such a manner as to track back the incidence direction of the radiation. The image processing unit 168 receives the information from the signal processing unit 167 and displays it as an image.

The three-dimensional scattering radiation imaging apparatus 170 shown in Fig. 8 is provided with another radiation detection unit 171 that detects radiation by a mechanical focusing method. The radiation detection unit 171 includes a light collector 172, a detector 173, a signal processing unit 176, and an image processing unit 177. The concentrator 172 is a means for geometrically limiting and detecting the radiation having the desired direction, such as a parallel hole concentrator, a pinhole concentrator, URA, MURA, HURA, etc. . The detector 173 includes a semiconductor material 174 and an electronic circuit 175. The signal processor 176 receives the information about the position and the energy of the radiation from the detector 173 and calculates the position of the radiation source in such a manner as to track back the incidence direction of the radiation. The image processing unit 177 receives information from the signal processing unit 176 and displays it as an image.

Here, as the semiconductor material 174, CdTe, CZT, TlBr, or the like may be used. A detector 173 using such semiconductor material 174 is capable of detecting radiation using an output pulse without the need for an optical sensor. The output pulse of the detector 173 is provided to the signal processing unit 176 and processed. The processed signal is again supplied to the image processing unit 177 and converted into an image.

9 and 10 show various modified examples of a radiation medical apparatus having a three-dimensional scattering radiation imaging apparatus.

The radiation medical device 200 having the three-dimensional scattering radiation imaging apparatus shown in FIG. 9 includes a radiation irradiation unit 210 for radiating radiation, a three-dimensional scattering radiation imaging device 220 for detecting a radiation irradiation position and a dose distribution, And a controller (not shown) for controlling the irradiation unit 210 and the three-dimensional scattering radiation imaging apparatus 220.

The three-dimensional scattering radiation imaging apparatus 220 includes a plurality of radiation detection units 221. One of the plurality of radiation detection units 221 is coupled to the radiation irradiation unit 210 and the remaining two radiation detection units 221 are installed at different positions to be spaced from each other. As the radiation detection unit 221, a compact camera structure using an electronic focusing method as described above, or a mechanical focusing structure using a focusing device can be used. The plurality of radiation detection units 221 may be fixedly installed, or may be movably installed by separate drivers.

The three-dimensional scattering radiation imaging apparatus 220 of the radiation medical device 200 according to the present embodiment is configured to detect a plurality of radiation detecting units 221 capable of detecting radiation by arranging the radiation detecting units 221 in various directions around the patient P, Directional image information.

10 includes a radiation irradiation unit 310 for irradiating radiation, an irradiation unit driver 320 for moving the radiation irradiation unit 310, and a plurality of radiation irradiation units 310, A CT detector 330, a three-dimensional scattering radiation imaging apparatus 340 for detecting a radiation irradiation position and a dose distribution, and a controller (not shown).

The irradiation unit 310 is moved by the irradiation unit driver 320 to irradiate the patient P while rotating 360 degrees around the patient P. [ The irradiation unit 310 and the irradiation unit driver 320 are controlled by a controller.

The three-dimensional scattering radiation imaging apparatus 340 includes a plurality of radiation detection units 341. As the radiation detection unit 341, a compact camera structure using an electronic focusing method as described above, or a mechanical focusing structure using a focusing device can be used.

The plurality of radiation detection units 341 are respectively coupled to the plurality of CT detectors 330 and moved by the detection unit driver 350. The plurality of radiation detection units 341 and the plurality of CT detectors 330 measure radiation scattered from the patient P in real time while rotating 360 degrees around the patient P by the detection unit driver 350. [ The inter-coupled radiation detection unit 341 and the CT detector 330 can work together to reconstruct the three-dimensional image.

The three-dimensional scattering radiation imaging apparatus 340 of this embodiment is combined with the CT detector 330 of the tomotherapy apparatus, thereby enhancing the detection efficiency of the scattered radiation and fusing the CT image with excellent anatomical information, The distribution can be obtained more accurately in real time.

As described above, the radiation medical device having the three-dimensional scattering radiation imaging apparatus according to the present invention can be configured in a variety of configurations within a range capable of measuring radiation in real time during treatment without accompanying additional dose irradiation.

For example, the number of radiation detecting units constituting the three-dimensional scattering radiation imaging apparatus and the number of detectors provided in the radiation detecting unit are not limited to those shown in the drawings, and may be variously changed.

The foregoing description is merely illustrative of the technical idea of the present invention, and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the scope of equivalents should be construed as falling within the scope of the present invention.

100, 200, 300 ... Radiation medical equipment 110, 210, 310 ... Radiation irradiation unit
120 ... driver
130, 150, 160, 170, 220, 340 ... Three-dimensional scatter radiation imaging apparatus
131, 151, 161, 171, 221, 341 ... Radiation detection unit
132, 152 ... First detectors 133, 153 ... Second detector
134, 154 ... Third detector 135, 164 ... Scintillator
136, 165 ... optical sensors 137, 156, 166, 175 ... electronic circuit
138, 157, 167, 176 ... signal processing sections 139, 158, 168, 177, ...,
140 ... controller 155, 174 ... semiconductor material
163, 173 ... detector 320 ... irradiation unit driver
330 ... CT detector 350 ... detection unit driver

Claims (16)

A first detector for detecting the position and energy of the radiation irradiated from the radiation source and scattered from the object; A second detector for detecting the position and energy of the radiation passing through the first detector; A third detector for detecting the position and energy of the radiation passing through the second detector; A signal processor for receiving the information about the position and the energy of the radiation detected by the first detector, the second detector and the third detector and determining the position of the radiation source in such a manner that the direction of the radiation is reversed; And an image processor receiving the information from the signal processor and displaying the image as an image,
Wherein the signal processing unit calculates the energy (E) absorbed by the target object expressed by Equation (3) through the following Equations (1) and (2) when knowing the direction of the radiation to be irradiated on the object in the radiation source: 3D Scattering Radiation Imaging System.
[Equation 1]
Figure 112017014825350-pat00022

(hv 'is the photon energy scattered from the object, hv is the photon energy of the radiation source, θ is the scattering angle from the object, and m0c 2 is the stop mass of the electron)
&Quot; (2) "
Figure 112017014825350-pat00023

&Quot; (3) "
Figure 112017014825350-pat00024
. The method according to claim 1,
Wherein the first detector, the second detector, and the third detector each comprise a scintillator and an optical sensor, and are composed of a Compton camera structure. The method according to claim 1,
Wherein the first detector, the second detector, and the third detector each comprise a semiconductor material selected from the group consisting of CdTe, CZT, and TlBr, and have a Compton camera structure. delete The method according to claim 1,
The signal processing unit detects the energy and direction of scattering radiation scattered by the object and incident on the first detector, the second detector, and the third detector when the direction of the radiation irradiated to the object is unknown in the radiation source, And calculating a radiation dose to be irradiated to the object by comparing the computed simulation value and the actual measurement value. The method according to claim 1,
The signal processing unit three-dimensionally represents the positions where the radiation is scattered from the first detector, the second detector, and the third detector, and includes a total of four-dimensional matrix including the energy absorbed by the object, Dimensional scattering radiation imaging device. The method according to claim 6,
Wherein the signal processing unit corrects the absolute value of the energy absorbed by the object through simulations performed before the irradiation of the radiation when the angle of incidence on the object of the radiation is unknown. A radiation irradiation unit for irradiating the object with radiation; A detector for detecting the position and energy of the radiation irradiated from the irradiation unit and scattered from the object; and a controller for receiving information on the position and energy of the radiation detected by the detector, A radiation detecting unit including a signal processing unit for obtaining a position of the irradiation unit, and an image processing unit for receiving information from the signal processing unit and displaying the image as an image; And a controller for controlling the radiation irradiation unit and the radiation detection unit,
The signal processing unit calculates the energy E absorbed by the target object expressed by Equation (3) through the following Equations (1) and (2) when the direction of the radiation irradiated to the target object in the irradiation unit is known Radiological medical equipment.
[Equation 1]
Figure 112017014825350-pat00025

(hv 'is the photon energy scattered from the target object, hv is the photon energy, θ is the scattering angle from the target object, m0c 2 is a rest mass of the electron irradiation unit)
&Quot; (2) "
Figure 112017014825350-pat00026

&Quot; (3) "
Figure 112017014825350-pat00027
 9. The method of claim 8,
And a driver for moving the irradiation unit,
Wherein the radiation detection unit is combined with the radiation irradiation unit and detects radiation while moving with the radiation irradiation unit by the driver. 9. The method of claim 8,
An irradiation unit driver for moving the irradiation unit; And
And a detection unit driver for moving the radiation detection unit. 9. The method of claim 8,
Wherein the plurality of radiation detection units are spaced apart from each other. 9. The method of claim 8,
Wherein the detector of the radiation detection unit comprises:
A first detector for detecting the position and energy of the radiation irradiated from the irradiation unit and scattered from the object,
A second detector for detecting the position and energy of the radiation passing through the first detector,
And a third detector for detecting the position and energy of radiation passing through said second detector. 9. The method of claim 8,
Wherein the radiation detection unit is a compton camera whose detector comprises a scintillator and an optical sensor. 9. The method of claim 8,
Characterized in that the radiation detection unit is a compact camera whose detector comprises a semiconductor material selected from the group consisting of CdTe, CZT and TlBr. 9. The method of claim 8,
Wherein the radiation detection unit further comprises a focusing device for focusing the scattered radiation at the object and for sending it to the detector. 9. The method of claim 8,
And a CT detector coupled to the radiation detection unit to reconstruct a three-dimensional image.
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Publication number Priority date Publication date Assignee Title
KR20210024044A (en) * 2018-07-26 2021-03-04 도시바 에너지시스템즈 가부시키가이샤 Treatment system, calibration method, and program
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KR20220068000A (en) * 2020-11-18 2022-05-25 서울대학교병원 Method for calculating dose for volume of target area and system performing the same
KR102538117B1 (en) 2020-11-18 2023-05-31 서울대학교병원 Method for calculating dose for volume of target area and system performing the same
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