KR101741766B1 - Apparatus for capturing images of blood cell - Google Patents

Apparatus for capturing images of blood cell Download PDF

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Publication number
KR101741766B1
KR101741766B1 KR1020160109890A KR20160109890A KR101741766B1 KR 101741766 B1 KR101741766 B1 KR 101741766B1 KR 1020160109890 A KR1020160109890 A KR 1020160109890A KR 20160109890 A KR20160109890 A KR 20160109890A KR 101741766 B1 KR101741766 B1 KR 101741766B1
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South Korea
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image
lens
blood
camera
unit
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KR1020160109890A
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Korean (ko)
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KR20170032175A (en
Inventor
정평수
이규만
박성종
김영기
박진희
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(주)뉴옵틱스
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    • G06F19/321—
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F17/30289—
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass

Abstract

According to one aspect of the present invention, there is provided a blood cell image capturing apparatus comprising: a camera section including at least one camera; a lens section including a plurality of lenses having different magnifications; A support for supporting the blood smear slide, a lens and a lens in an aligned state, a transfer part for adjusting a relative position of the blood smear slide, a light source for providing illumination, And a control section for controlling the camera section, the lens replacement section, the transfer section, and the illumination section, respectively, to obtain a predetermined image from the blood smeared on the slide.

Description

[0001] Apparatus for capturing images of blood cells [0002]

TECHNICAL FIELD The present invention relates to a blood cell image capturing apparatus.

An image analyzer (IA: Image Analyzer) is an apparatus for imaging and analyzing blood cells contained in blood-smear blood samples. Particularly, the image analyzer can measure the blood cell image captured through WBC (White Blood Cell) analysis by five kinds, basophil, neutrophil, acidic white blood cell (Eosinophil), mononuclear leukocyte (Monocyte) Lymphocyte (Lymphocyte) is classified as a device to distinguish.

Actually, leukocytes may exist in various forms depending on the patient's condition, and the hematocrit counting the number of each type is very important for diagnosing the condition of the patient, diagnosis and tracking of the disease.

Therefore, various methods are being developed to improve the accuracy of the image analyzer's discrimination results.

An object of the present invention is to provide a blood cell image capturing apparatus capable of improving an image capturing speed and an image quality.

According to an aspect of the present invention, there is provided a camera system including a camera unit including at least one camera, a lens unit including a plurality of lenses having different magnifications, A lens replacement portion for positioning the lens, a support for placing the blood smear slide, a camera and lens in an aligned state, a transfer portion for adjusting the relative position of the blood smear slide, and a light source for providing illumination. And a control section for controlling the camera section, the lens replacement section, the transfer section, and the illumination section to obtain a predetermined image from the blood smearing on the slide, respectively.

Further, the illumination unit may include a collimating lens and a collimating lens arranged to sequentially pass the light irradiated from the light source.

Further, the camera section may include a camera for photographing and a camera for auto-focusing.

Further, the lens portion may include a low magnification lens and a high magnification lens.

Further, the control unit may be provided to capture a first region of blood smeared on the slide with a low magnification lens, and to generate coordinate values of blood cells appearing in the image of the first region.

In addition, the control unit can select one or more necessary regions for obtaining a high-resolution image of the blood cells in the first region, and align the high magnification lens with respect to the camera in order to image the selected required region with the high magnification lens.

In addition, the control unit may be provided to match the center coordinate values of the blood cells in the first area and the necessary area.

In addition, the control unit may control to sequentially capture images through the high magnification lens along predetermined trajectories connecting the plurality of required areas.

As described above, the hemocyte image pickup apparatus according to at least one embodiment of the present invention can improve the image pickup speed and image quality.

1 is a conceptual diagram illustrating a blood cell differentiation system according to an embodiment of the present invention.
2 is a configuration diagram illustrating a blood-cell image capturing apparatus according to an embodiment of the present invention.
Figs. 3 to 5 are views showing some components of a blood cell image capturing apparatus according to an embodiment of the present invention. Fig.
FIG. 6 through FIG. 9 are views for explaining a blood image processing method according to an embodiment of the present invention.
FIGS. 10 to 11 are views for explaining an image capturing method of a blood smear sample according to an embodiment of the present invention.

Hereinafter, a blood cell differentiation system, a blood cell image imaging device, a blood image processing method, and an image capturing method of a blood smear sample according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

In addition, the same or corresponding reference numerals are given to the same or corresponding reference numerals regardless of the reference numerals, and redundant description thereof will be omitted. For convenience of explanation, the size and shape of each constituent member shown in the drawings are exaggerated or reduced .

Fig. 1 is a conceptual diagram showing a blood cell differentiation system 1 according to an embodiment of the present invention.

The blood cell differentiation system includes an image analyzer (IA) 100 and a manual review center (MRC) In this document, 'blood cells' may mean red blood cells or white blood cells, but for convenience of explanation, 'blood cells' refers to 'white blood cells' as an example.

The image analyzer 100 is configured to capture a blood cell image in the blood smear slide 400 (see FIG. 10), to distinguish blood cells from the captured blood cell image, and to store the discrimination result. The image analyzer 100 includes one or more blood cell image capture devices 200 (see FIG. 2).

The manual review center 10 includes one or more terminals 12 for displaying blood cell images, discrimination results and patient information transmitted from the image analyzer 100. The manual review center 10 includes an MRC server 11 and a plurality of terminals 12 connected to the MRC server through wired or wireless communication so as to transmit / receive predetermined information. Also, the terminal 12 includes a display unit and an input unit, and may be, for example, a notebook computer, a computer, a tablet PC, or a smart phone. Specifically, the display unit is configured to display a blood cell image, a result of discrimination, and patient information transmitted from the image analyzer 100, and the input unit is configured to input discrimination information after the blood cell image is discriminated by the discriminating unit (pathologist).

In addition, the patient information (also referred to as "meta information") may include one or more of age, sex, white blood cell count, red blood cell count, hemoglobin count, hematocrit count and platelet count.

In addition, the manual review center 10 is configured to transmit the inputted discrimination result to the image analyzer 100 when the discrimination result of the discriminator is inputted through the terminal 12.

Specifically, the manual review center 1000 receives a blood cell image package from the image analyzer 100, and provides an environment in which a blood diagnostic specialist can manually identify the blood cell image through a web browser.

Particularly, the manual review sensor 10 receives blood cell image packages from large hospitals all over the world, and a specialized pathologist classifies each blood cell image into a hand, and delivers the results to the hospital requesting the discrimination and manages the result And to stabilize the discrimination system so that the analysis error is less than 1% through the manual review center 10.

In one embodiment, the image analyzer 100 compresses the white blood cell (WBC) image and sends it to the manual review sensor 10 via the network. The manual review center 10 receives the white blood cell image and stores it in the database 11 (server). At this time, for security and authentication, the manual review sensor 10 can confirm whether the data is received from the registered image analyzer 100 or a message authentication code. In addition, in the manual review center 10, since the result of the discrimination is confirmed, the connection between the image analyzer 100 and the manual review sensor 10 must be maintained. Further, the manual review center 10 can release the leukocyte image package, and obtain the meta information and the image file. In addition, the leukocyte image package may include the ID (device name) of the image analyzer and the patient ID. Also, at the same time, it is not possible to perform discrimination for the same leukocyte image by another pathologist.

Specifically, the image analyzer 100 can create an encrypted channel with the manual review center 10 server 11. This can use general SSL encryption, the MRC server 11 has to provide the SSL service, and the image analyzing unit 100 can prepare the libraries necessary for using the HTTPS service.

The image analyzer 100 and the manual review center 10 must generate a message authentication code (MAC) for a message transmitted and received between the image analyzer 100 and the manual review center 10, have.

In addition, the image analyzer 100 requests the manual review center 10 for blood discrimination, and the manual review center 10 stores the received discrimination request in the server 11. Further, when the discriminator of the manual review center 10 completes the blood discrimination, the status of the discrimination request is changed to the 'COMPLETE' state. At this time, the manual review center 10 can generate the result information for reporting to the image analyzer 100 when the manual review center 10 receives the discrimination request of the COMPLETE state. In addition, the manual review center 10 transmits the result of the discrimination to the image analyzer 100. [ Also, the image analyzer 100 can notify the manual review center 10 that the discrimination result is well received. The manual review center 10 can confirm that the image analyzer 100 has received the discrimination result well and can close the discrimination request.

On the other hand, the image analyzer 100 captures the entire image of the blood smeared on the slide with the low magnification lens at the time of imaging the blood cell image, and after the lens replacement, It may be provided to capture a partial image. Specifically, the image analyzer 100 may be configured to firstly determine a blood cell distribution from a low-magnification image, then to select a region in which a blood cell exists, and secondarily to obtain a high-magnification image of the corresponding region.

In addition, the image analyzer 100 may be configured to generate a plurality of blood cell images by sequentially capturing a partial image along predetermined trajectories connecting the areas where the blood cells are located. For example, the image analyzer 100 may be configured to obtain about 100 blood cell images from one blood smear slide.

In addition, the image analyzer 100 may be provided to correct the coordinate values of blood cells according to magnification change (change from low magnification to high magnification) before photographing with a high magnification lens.

In addition, the image analyzer 100 may include an illumination unit for providing illumination upon imaging of a blood cell image. For example, the illumination unit may include a condenser lens and a parallel optical lens arranged such that the illumination unit passes through the light source and the light emitted from the light source in turn passes through the slide.

Fig. 2 is a configuration diagram showing a hemocyte image capturing apparatus 200 according to an embodiment of the present invention, and Figs. 3 to 5 are views showing some components of a hemocyte image capturing apparatus according to an embodiment of the present invention .

As described above, the image analyzer 100 constituting the blood cell discrimination system 1 includes at least one blood cell image capturing apparatus 200 for capturing blood cell image.

2, the hemocyte image capturing apparatus 200 includes a camera unit 210, a lens unit 220, a lens replacement unit 223, a support 230, an illumination unit 240, a transfer unit and a control unit 250, .

Specifically, the blood cell image capturing apparatus 200 includes a camera unit 210 including one or more cameras 211 and 212, a lens unit 220 including a plurality of lenses 221 and 222 having different magnifications, And a lens replacement unit 223 for positioning a specific lens among the plurality of lenses 221 and 222 to be aligned with the camera. The blood cell image capturing apparatus 200 further includes a support table 230 on which the blood smear slide 400 (see Fig. 10) is seated, a camera and lens in an aligned state, a transfer section for adjusting the relative position of the blood smear slide, And an illumination unit 240 including a light source 241 for providing light. The hemocyte image capturing apparatus 200 further includes a control unit for controlling the camera unit 210, the lens replacement unit 223, the transfer unit, and the illumination unit 240 to obtain a predetermined image from the blood smeared on the slide 400, (350).

The illumination unit 240 may include a condenser lens 242 and a parallel optical lens 243 arranged to sequentially pass the light emitted from the light source 241. The light source 241 may include a metal halide.

In addition, the camera unit 210 may include a camera 211 for capturing images and a camera 212 for autofocusing. For example, the imaging camera 211 may be a CMOS camera, and may be a high resolution camera of about 20M or more (e.g., 25M) with a resolution of 0.2 mu m or less. In particular, the higher the resolution, the wider the field of view (FOV), and the greater the number of blood cells can be detected.

The lens unit 220 may include a low magnification lens 221 (e.g., x1 to x10) and a high magnification lens 222 (e.g., x50 to x100), and each lens may be an objective lens .

The control unit 250 images the first area (e.g., the entire area) of the blood smeared on the slide with the low magnification lens 221 and displays the coordinates of the blood cell in the image of the first area , xy coordinates).

In addition, the controller 250 selects at least one necessary region for obtaining a high-resolution image of the blood cells in the first region, aligns the high magnification lens 222 with respect to the camera in order to image the selected required region with the high magnification lens . That is, when the primary imaging through the low magnification lens 221 is completed, the control unit 250 controls the lens replacement unit 223 to replace the high magnification lens 222. [

In addition, the controller 250 may be arranged to match the center coordinates of the blood cells in the first region and the required region.

In addition, the control unit 250 can control the image pickup through the high magnification lens in order along the predetermined locus connecting the plurality of necessary areas.

Hereinafter, a blood image processing method using the blood cell image capturing apparatus 200 having the above structure and an image capturing method of a blood smear sample will be described in detail.

FIG. 6 through FIG. 9 are views for explaining a blood image processing method according to an embodiment of the present invention.

The blood image processing method includes a first imaging step of acquiring an image (1000) of an entire area of blood smeared on a slide with a low magnification lens (221), and a second imaging step of obtaining, based on the distribution of blood cells in the image A selection step of selecting one or more necessary areas for acquiring a high magnification image 1001 of blood cells, a correction step of correcting the coordinate values of the blood cells due to the magnification change, and a second imaging step of imaging the necessary area with the high magnification lens 222 .

Further, the correcting step may include matching the center coordinate values of the blood cells in the whole area and the necessary area. Referring to FIG. 7, FIG. 7A shows a low magnification image 1000 for the entire area, and FIG. 7B shows a high magnification image 1001 for the required area. Specifically, in the low magnification image 1000, the target white blood cell is grabbed and replaced with a high magnification lens on the basis of the target, and the center value of the target white blood cell is confirmed in the high magnification image, and the difference value of the center coordinate value is corrected The reference position of the center of the coordinate is not changed even if there is a change in magnification of the lens.

6, in the selecting step, the number of blood cells in each divided space 310 is determined by dividing the grid line 300 provided on the low magnification image obtained in the first imaging step into a plurality of spaces . Here, the divided space 310 in which the blood cells exist is selected as the above-described required area.

In addition, the second imaging step may include a step of sequentially taking an image through the high magnification lens along a predetermined locus 313 (see Fig. 9) that successively connects the plurality of necessary areas. That is, by adjusting the relative positions of the camera and the lens in the alignment state and the blood smear slide through the above-described transfer unit, it is possible to continuously capture a high magnification image of blood cells.

Further, each imaging step may include the step of irradiating light from the light source 241 and passing through the condenser lens 242 and the parallel optical lens 243 in order, to the slide 400 side.

Further, as described above, each imaging step can be carried out through a CMOS camera.

Referring to FIG. 8, the blood image processing method may further include a generation step of generating an image 1002 for blood differentiation by correcting the blood image so that the blood image is in the center in the high magnification image 1001 obtained in the second image capturing step .

For example, the discriminating image 1002 can be generated by cutting the high magnification image 1001 such that the center of the white blood cell is at the center of the image, and is located at about one-third of the horizontal length.

The above-described image analyzer 100 performs the discrimination based on the internal algorithm based on the discriminating image 1002. The result of the discrimination of the image analyzer 100 is transmitted to the manual review center 10 as described above.

6 and 9, a blood image processing method includes capturing an entire region of the blood smear sample 400 with a low magnification lens 221 (for example, x10) to obtain a low magnification image, A step of dividing the low magnification image into a plurality of spaces with reference to the grid line 300 to derive a blood cell distribution based on the number of blood cells in each of the divided spaces 310 (refer to FIG. 6) Selecting a plurality of required areas 310 for image acquisition and obtaining a high magnification image along a predetermined trajectory 313 connecting the plurality of required areas 310 through a high magnification lens (e.g., xlOO) . In particular, the unexplained reference numeral 311 denotes an image capturing effective region in which a blood vessel exists, and the reference numeral 312 denotes an image capturing invalid region in which a blood vessel is not present. That is, during transfer along a predetermined trajectory, a high magnification image is acquired only in the imaging effective region, and the imaging invalid region can pass through without imaging.

FIGS. 10 to 11 are views for explaining an image capturing method of a blood smear sample according to an embodiment of the present invention.

Referring to FIGS. 9 and 10, when the slide 400 enters the support, the focus can be adjusted through the camera for auto focusing. At this time, a low magnification image for each divided space 310 divided by the grid line 300 along the predetermined locus 313 along the edge region of blood smearing on the slide 400 can be obtained. At this time, based on the low magnification image in FIG. 10 (c), white blood cells can be detected and the position of the white blood cells can be coordinateized. At this time, after calculating the required area in the entire area of the low magnification image shown in FIG. 10C, a high magnification image can be obtained with the high magnification lens with respect to the necessary area as shown in FIG. 10D. 10 (e), a discriminating image can be generated for each white blood cell from a high magnification image.

The image capturing method of the blood smear specimen 400 is based on the difference in brightness of the partial images 310 of the blood smear specimen 400 so that the edge area E of the blood smear specimen, . When the blood is smudged, blood cells are distributed in the area at the edge. Therefore, it is effective to pick up a trajectory 313 around the edge region E and pick up the image.

Further, the image capturing method of the blood smear sample may further include a selection step of selecting a plurality of necessary areas 310 for obtaining a high magnification image of blood cells based on the position of the edge area E in the entire image .

In addition, the image capturing method of the blood smear sample may further include an image capturing step of performing image capturing through a high magnification lens along a predetermined locus 313 connecting a plurality of necessary areas 310. [

On the other hand, the whole image of the blood smear sample can be obtained by obtaining a partial image for some areas of the blood smear sample, and merging the partial images.

Further, partial images may be distinguished by a first grid line (e.g., 300 in FIG. 6) on the entire image. Alternatively, the required area may be distinguished by a first grating line (e.g., 300 in FIG. 6) and a second grating line (e.g., 300 in FIG. 11).

Also, the required area 310 can be selected based on the distribution of the blood cells in the whole image.

The foregoing description of the preferred embodiments of the present invention has been presented for purposes of illustration and various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention, And additions should be considered as falling within the scope of the following claims.

1: hemocyte differentiation system
10: Manual Review Center
100: Image Analyzer
200: hemocyte image pickup device
210:
220:
230: Support
240:
250:
300: Grid line
310:
311: imaging effective area
312: imaging invalid area
313: Trajectory
400: blood smear slide
1000: Low magnification image
1001: High magnification image
1002: Image for discrimination

Claims (8)

A camera unit including at least one camera;
A lens unit including a plurality of lenses having different magnifications;
A lens replacement unit for positioning a specific lens among the plurality of lenses to be aligned with the camera;
A support on which the blood smear slide is seated;
A camera and a lens in an aligned state, and a transfer unit for adjusting a relative position of the blood smear slide;
An illumination unit including a light source for providing illumination; And
And a control unit for controlling the camera unit, the lens replacement unit, the transfer unit, and the illumination unit to obtain a predetermined image from the blood smeared on the slide,
The lens portion includes a low magnification lens and a high magnification lens,
The control section is adapted to image a first region of blood smeared on the slide with a low magnification lens and to generate coordinate values of blood cells appearing in an image of the first region,
The control unit selects at least one necessary region for obtaining a high resolution image of the blood cells in the first region and aligns the high magnification lens with respect to the camera in order to image the selected required region with the high magnification lens,
And the control unit is arranged to match the center coordinate value of the blood cell in the first area and the necessary area. The method according to claim 1,
And the illuminating unit includes a collimating lens and a collimating lens arranged so as to sequentially pass the light irradiated from the light source. The method according to claim 1,
Wherein the camera section includes a camera for imaging and an auto focusing camera. delete delete delete delete The method according to claim 1,
And the control unit controls imaging so that the imaging through the high magnification lens is sequentially performed along the predetermined trajectory connecting the plurality of necessary areas.
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KR20190022028A (en) 2017-08-25 2019-03-06 (주)뉴옵틱스 Apparatus for capturing images of blood cell
KR20190023886A (en) 2017-08-30 2019-03-08 (주)뉴옵틱스 Apparatus for capturing images of blood cell and image analyzer with the same
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