KR101734043B1 - Composition for haridye comprising polydopamine and metal salt as effective component - Google Patents

Abstract

The present invention relates to a composition for hairdye, comprising polydopamine and metal salt as effective component. According to the present invention, it is possible not only to synthesize a melanin-like polyphenylamine, which is an actual component of hair, and when polydopamine and ferrous sulfate (FeSO_4) are mixed and applied to hair, increases dyeing affinity in hair, and also enhances durability of dyeing due to resistance to surfactants.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for a hair dye containing polyadopamine and metal salt as an active ingredient,

The present invention relates to a composition for hair dyeing agents containing polypodamine and a metal salt as an active ingredient.

In general, hair dye can be classified into temporary hair dye, semi-permanent hair dye and permanent hair dye depending on the difference of dyeing effect. Among them, the permanent hair dye agent is made so that the dye penetrates into the hair follicle to precipitate the dye molecules in the follicle, and the hair dye agent can be discolored and colored by the addition action of penetration and oxidizing agent. The permanent hair dyeing agents can be classified into vegetable hair dyeing agents, metal hair dyeing agents, oxidative hair dyeing agents and the like depending on dyes to be used, and most hair dyeing agents conventionally used are alkaline oxidizing hair dyeing agents among oxidative dyeing agents. Since the alkaline oxidizing hair dye agent contains an alkaline agent, the pH can be increased to swell the hair to accelerate dye deposition on the hair, and the hydrogen peroxide, which is a main component of the oxidizing agent, can act as a catalyst to rapidly break down the melanin pigment in the hair It is widely used because it has. However, the above-mentioned alkaline agent has a problem that it causes skin trouble or allergy in a person having a weak skin. In addition, since the above-mentioned alkaline agent swells the hair by increasing the pH, it reduces the gloss and gloss of the hair, dissolves the hair component and severely damages the hair, resulting in an unnatural color or hair.

On the other hand, dopamine is a monomolecular substance with a molecular weight of 153 (Da) having catechol and amine functional groups. When a substance to be surface-modified is put into an aqueous solution of dopamine having the same condition (pH 8.5) It has been reported that a polydopamine (pDA) coating layer is formed by oxidation of catechol. The polydopamine coating is a functional surface modification technique using dopamine, a monomolecular material composed of catechol, which is an important chemical functional group that shows adhesion in the adhesive proteins of the previously studied mussels. Recently, pDA (polydopamine) Surface modification technology. Polydodamine shows excellent surface attachment ability on various surfaces, regardless of the chemical nature of the surface, as well as the ability of mussels to adhere to various surfaces through their adhesive proteins in the aquatic environment. In addition to the specific surface attachment ability, the modification of the surface of the polypodamine can be performed by a secondary surface modification by the chemical properties of the polypodamine surface, and thus various studies are being conducted. The polydopamine coating film formed on the surface still has a catechol functional group. The catechol functional group has a redox power and a covalent bond forming ability with an amine functional group to form metal nanoparticles on a desired surface, or an amine functional group Can also be introduced to the surface as a secondary surface modification. It has also been successfully reported that the degree of hydrophilicity of the surface can be controlled or a bioactive molecule such as gelatin or basic fibroblast growth factor (bFGF) can be bound to the surface. Cell-or tissue-friendly materials play an important role in artificial tissue regeneration using tissue engineering techniques. However, existing techniques have difficulties in maintaining water with a strong adhesive force in the living body, which is a main constituent. However, the method of modifying the surface of polydopamine with strong adhesion is not only an adhesive but also a biocompatible coating technique which is the most important factor of biomaterial, and it has a potential to be a very important technique in development of various adhesive biomaterials and tissue engineering Have.

Korean Patent Publication No. 1999-003786 discloses a temporary hair coloring composition, and Korean Patent Publication No. 2002-0074768 discloses a hair hair dye composition containing a metal compound. However, a composition for a hair dye containing the polypodamine and the metal salt of the present invention as an active ingredient has not yet been disclosed.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned needs. The present inventors have induced self-polymerization through oxidation of dopamine to synthesize polypodamine, which is mixed with ferrous sulfate (FeSO ₄ ) Coated on cucumber hair and treated for 1 hour. As a result, the present inventors completed the present invention by confirming that they exhibit permanent dyeing effect due to resistance to surfactants as well as being stained with a completely black series.

In order to solve the above problems, the present invention provides a composition for hair dyeing agent containing polydopamine and a metal salt as an active ingredient.

The present invention also relates to a method for preparing a compound of formula (I), comprising: 1) inducing self-polymerization through oxidation of dopamine to synthesize polypodamine; And

2) mixing 0.1 to 10,000 parts by weight of a metal salt with 100 parts by weight of the polypodamine synthesized in the step 1).

The present invention also provides a hair dyeing method comprising applying the hair dye composition to hair.

The present invention relates to a composition for hair dyeing agent containing polydodamine and a metal salt as an active ingredient. According to the present invention, it is possible to synthesize a melanin-analogous polydodamine, which is an actual component of hair, Iron (FeSO ₄ ) is added to the hair to enhance the dyeability in the hair and to increase the persistence of the dyeing due to the resistance to the surfactant.

FIG. 1 is a photograph (A) showing the hair color of cyan hair and a graph (B) showing the dyeing power when the hair is treated with the mixture of polydodamine and ferrous sulfate (FeSO ₄ ) according to an embodiment of the present invention . Control is a negative control without any treatment.
FIG. 2 is a graph showing the dyeing sustainability of hair when treated with fresh hair by mixing polydodamine and ferrous sulfate (FeSO ₄ ) according to an embodiment of the present invention.

In order to accomplish the present invention, the present invention provides a composition for hair dyeing agent containing polydopamine and a metal salt as an active ingredient.

The above-mentioned polydodamine refers to dopamine of a dimer or higher, and refers to an oxidized polymerized product in which dopamine is not present through the macromolecularization of dopamine.

The polypodamine may be included in an amount of 0.0001 to 20 parts by weight based on 100 parts by weight of the composition, but is not limited thereto.

When the amount of the polypodamine is less than 0.0001 parts by weight based on 100 parts by weight of the composition, the coloring effect is insignificant and the coloring effect of the hair hardly occurs. When the amount exceeds 20 parts by weight, coloring is excessively generated, .

What is used as the metal salt is a bivalent or trivalent metal salt, which is a substance having reactivity with other substances. Unlike general ionic bonds, the metal salts have coordination bonds. The metal salts used as mordants are metal salts of metals such as copper (Cu), cadmium (Cd), arsenic (As), mercury (Hg), lead (Pb), chromium (Cr), iron (Fe) However, copper, cadmium, arsenic, mercury, lead, and chromium are harmful metal substances of the human body. Therefore, it is preferable to use ferrous sulfate containing iron ions having a large coordination bonding ability, Ferric chloride, ferric hydrochloride, and hydrates thereof, and more preferably, ferrous sulfate can be used.

It is preferable to mix 0.1 to 10,000 parts by weight, more preferably 1 to 1,000 parts by weight, and further preferably 10 to 100 parts by weight of the metal salt with respect to 100 parts by weight of the polypodamine, It is not limited.

The composition for hair dyeing agent may exhibit a permanent dyeing effect, but is not limited thereto.

The composition for a hair dye containing the polypodamine and the metal salt of the present invention as an active ingredient can be applied as a powder, paste, cream, lotion or liquid formulations.

The polydopamine may be, but is not limited to, synthesizing polydodamine by inducing self-polymerization through the oxidation of dopamine.

In addition, the oxidation may be, but not limited to, treatment of dopamine with a basic buffer solution or an oxidizing agent.

The basic buffer solution may be a buffer solution having a pH of 8.0 or more, preferably, but not limited to, a pH 8.4 Tris-HCl buffer solution.

The oxidizing agent may comprise copper (I) chloride, ammonium peroxodisulfate, sodium periodate, potassium chloride, oxidase or mixtures thereof. In addition, the oxidizing enzyme may be peroxidase, a lactase, or a mixture thereof.

In addition, the composition for hair dyeing agent of the present invention may be added to the hair dyeing composition to such an extent that the effect of the present invention is not impaired. For example, antioxidants, metal sequestering agents, solvents, thickeners, perfumes, and conditioning agents are used, but they are not particularly limited as they can be commonly used in hair dyeing agents.

Examples of the antioxidant include ascorbic acid, erythorbic acid, cysteine hydrochloride, sodium sulfite and thioglycolic acid, and examples of the metal sequestering agent include EDTA, tetrasodium-EDTA, Ethanol, propyl alcohol, isopropyl alcohol, propylene glycol, hexylene glycol, diethylene glycol and the like can be used. As the thickening agent, higher alcohol having 14 to 22 carbon atoms can be used singly or in combination And a nonionic polymer and an anionic polymer can be used. As the conditioning agent, a cationic polymer, quaternary ammonium salt, silicon, or the like can be used.

In addition,

1) inducing self-polymerization through oxidation of dopamine to synthesize polypodamine; And

2) mixing 0.1 to 10,000 parts by weight of a metal salt with 100 parts by weight of the polypodamine synthesized in the step 1).

In the method for producing a hair dyeing composition of the present invention, 1 to 1,000 parts by weight of a metal salt is preferably mixed with 100 parts by weight of the above-mentioned polypodamine, more preferably 10 to 100 parts by weight, but not limited thereto.

The present invention also provides a hair dyeing method comprising applying the hair dye composition to hair. Specifically, 0.1 to 10,000 parts by weight of a metal salt may be mixed with 100 parts by weight of the above-mentioned polypodamine, and the mixture may be applied to the hair and treated for 0.5 to 1.2 hours.

In the hair dyeing method of the present invention, 0.1 to 10,000 parts by weight of the metal salt is preferably mixed with 100 parts by weight of the above-mentioned polypodamine, more preferably 1 to 1,000 parts by weight, further preferably 10 to 100 parts by weight And the mixture can be applied to the hair. It is preferable to treat the hair for 0.5 to 1.2 hours after the application, more preferably to 1 hour, but the present invention is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not limited thereto.

Example  One. Dyeing power  Measure

After dopamine (Dopamine.HCl, Sigma) was diluted to a concentration of 5 mg / ml in 100 mM Tris-HCl (pH 8.4) and treated at room temperature for 24 hours, self- Dopamine was synthesized. The synthesized polydopamine solution was mixed with 0.05 g / ml ferrous sulfate (FeSO ₄ ) and treated with keratin hair for 1 hour. After 1 hour, the keratin hairs were taken out and sufficiently washed and dried, and the color values (L *, a * and b *) were measured using a colorimeter (JCS-220, CHN Spec) . As a result, when the polydopamine and ferrous sulfate of the present invention were mixed and treated in contrast to a control (control) treated as described in FIG. 1, it was visually confirmed that the dyeing progressed in a black color system , And color intensity measurement showed that the intensity of hair color before and after dyeing increased significantly.

Example  2. Dyeing duration measurement

으로 계산하였다. 그 결과, 도 2에 개시된 바와 같이 본 발명의 폴리도파민 및 황산제1철을 혼합하여 처리된 염색모발에 계면 활성제를 반복적으로 처리하였을 때, 색 수치가 크게 변하지 않았으며 염색 지속력이 우수한 것을 확인할 수 있었다.Dyeing persistence was determined by using a surfactant resistance test. Sodium dodecyl sulfate (SDS) was diluted in distilled water to a concentration of 5 mg / ml, treated with dyed keratin hair repeatedly for 5 minutes, washed thoroughly with water And dried to determine if the dye stained through the colorimetric measurement (JCS-220, CHN Spec) was escaped by the surfactant. The degree of darkness of the color is represented by calculating the value E, and the value of E

Respectively. As a result, it was confirmed that when the surfactant was repeatedly treated with the dyed hair treated with the polydopamine and the ferrous sulfate of the present invention as shown in FIG. 2, the color value did not change greatly and the dyeing persistence was excellent there was.

Claims (6)

A composition for a hair dyeing composition comprising polydopamine and a metal salt as an active ingredient. The hair dyeing composition according to claim 1, wherein the polypodamine is contained in an amount of 0.0001 to 20 parts by weight based on 100 parts by weight of the composition. The hair dyeing composition according to claim 1, wherein the metal salt is ferrous sulfate (FeSO ₄ ). The hair dyeing composition according to claim 1, wherein 0.1 to 10,000 parts by weight of a metal salt is mixed with 100 parts by weight of the polypodamine. The composition for a hair dyeing agent according to claim 1, wherein the polydodamine is synthesized by inducing self-polymerization through oxidation of dopamine. 6. The composition according to claim 5, wherein the oxidation is treatment of dopamine with a basic buffer solution or an oxidizing agent.

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