KR101710008B1

KR101710008B1 - LED Mask for Photodynamic Therapy

Info

Publication number: KR101710008B1
Application number: KR1020150091806A
Authority: KR
Inventors: 심영기
Original assignee: 인제나노헬스주식회사
Priority date: 2015-06-29
Filing date: 2015-06-29
Publication date: 2017-02-24
Also published as: KR20170001986A

Abstract

The present invention relates to an LED mask for photodynamic therapy, and more particularly, to an LED mask for photodynamic therapy capable of enhancing photoactivation of an excited photo-sensitive material using a plastic material containing a specific mineral component will be.
The LED mask for photodynamic therapy according to the present invention utilizes the light energy of an LED dispersed or reflected around the LED while irradiating the LED light of a predetermined wavelength necessary for exciting the light sensitive material to the light sensitive material, By increasing photoactivation of the material, the photodynamic therapy effect can be enhanced.

Description

LED Mask for Photodynamic Therapy {LED Mask for Photodynamic Therapy}

The present invention relates to an LED mask for photodynamic therapy, and more particularly, to an LED mask for photodynamic therapy that can increase the activity of a light sensitive material using a specific mineral component.

In general, Photodynamic Therapy is the treatment of cancer cells or photosensitizers with infectious cell selectivity by irradiating the skin cells with light of a special energy wavelength capable of exciting the photosensitized substance, It is a technique to treat diseases by destroying cancer cells or infected cells by making oxygen molecules in the cells into singlet oxygen molecules with high activity.

The use of a short wavelength laser for irradiating a certain wavelength of light energy used to excite a photosensitive material in such a photodynamic therapy is widely used for medical applications. However, since it is necessary to use an expensive laser oscillator, Have been studied. LEDs can be more useful if there is no obstacle to reaching the light, especially on the surface of the skin.

Accordingly, there has been developed a method of treating acne without special side effects by utilizing a photodynamic therapy technique using LED to treat skin acne bacteria.

In this case, the degree of acne treatment is how much the correct light energy is enough to reach the subcutaneous acne bacteria. In other words, the treatment of acne depends on how deeply it reaches the subcutaneous acne bacteria using light energy with a certain range of wavelengths.

A conventional LED mask for photodynamic therapy is manufactured by attaching a plurality of LED chips to a mask molding formed by using a general plastic material in the form of a planted shape. The light-sensitive material separately applied to the skin is irradiated to the light emitted from the LED chip It can excite through energy and destroy acne bacteria and the like.

The conventional LED mask for photodynamic therapy has several tens to several hundreds of LED chips (for example, about 15 to about 200) operated by a power of 5 mW in order to excite a photosensitive material The necessary light energy is oscillated.

Japanese Patent Application Laid-Open No. 2001-145520 (May 29, 2001)

SUMMARY OF THE INVENTION The present invention has been made in view of the above-described conventional LED mask, and it is an object of the present invention to provide a LED light source that emits light of a predetermined wavelength, which is required to excite a light- An object of the present invention is to provide an LED mask for photodynamic therapy capable of enhancing the photodynamic therapy effect by increasing the photodynamic activity of the excited light sensitive material by recycling energy.

Accordingly, the present invention provides an LED mask for photodynamic therapy for emitting light energy for exciting a light-sensitive substance applied to skin, comprising: a mask molding formed using a composite composition prepared by mixing a plastic material and a mineral composite; And a plurality of LED chips dispersed in the mask molding and oscillating light for exciting the photosensitive material when external power is applied.

Specifically, the composite composition may be prepared by mixing 90 to 99.9% by weight of a plastic material and 0.1 to 10% by weight of a mineral composite, wherein the mineral composite comprises 35 to 60% by weight of silicon (Si) Wherein the mineral additive is selected from the group consisting of sodium (Na), magnesium (Mg), aluminum (Al), phosphorus (P), sulfur (S), potassium (K), calcium (Ca) (Ti), Fe (Fe), Co, Zr, Sr, Y, Zr, Mo, Ba, (Ce), praseodymium (Pr), thorium (Th), and chlorine (Cl).

The plastic material may be a mixture of one or more selected from among polyethylene, polypropylene, silicone plastic, polycarbonate, polyester, and polyurethane.

According to the present invention, there is provided an LED mask for photodynamic therapy for emitting light energy for exciting a photosensitive material applied to skin, comprising: a first mask sheet adhered to each other by a composite composition formed by mixing an adhesive material and a mineral composite; A mask sheet portion made of a second mask sheet; And a plurality of LED chips dispersed on one side of the mask sheet and oscillating light for exciting the photosensitive material when external power is applied.

Specifically, the composite composition is prepared by mixing 90 to 99.9% by weight of an adhesive material and 0.1 to 10% by weight of a mineral composite, and the mineral composite comprises 35 to 60% by weight of silicon (Si) and 40 to 65% (K), calcium (Ca), magnesium (Mg), aluminum (Al), phosphorus (P) (Ti), Fe, Fe, Co, Zn, Sr, Y, Zr, Mo, Ba, La, (Ce), praseodymium (Pr), thorium (Th), and chlorine (Cl).

The adhesive material may be a mixture of one or more selected from among polyvinyl difluoride (PVdF), styrene butadiene rubber (SBR), polyvinyl alcohol (PVA), and Teflon (PTFE).

The LED mask for photodynamic therapy according to the present invention is an LED mask for photodynamic therapy, which comprises a light-sensitive material, which reflects light emitted from an LED, which is dispersed or reflected around the LED, The photodynamic therapy effect can be improved and the power consumption for operation of the LED chip can be reduced.

1 is a front perspective view of an LED mask for photodynamic therapy according to the present invention;
FIG. 2 is a schematic cross-sectional structural view of an LED mask for photodynamic therapy according to an embodiment of the present invention and a use form
FIG. 3 is a schematic cross-sectional structural view of an LED mask for photodynamic therapy according to another embodiment of the present invention,

Hereinafter, the present invention will be described with reference to the accompanying drawings.

The present invention relates to a method for increasing the effect of photodynamic therapy using a mineral component called Curamics in the production of a mask type photodynamic therapy light irradiator which can be worn on a face, The excitation light energy dispersed or reflected from the user's skin during the irradiation of the LED light to excite the excitation light is supplied to the mask molding of the plastic material containing the cura mix to thereby provide light energy having a predetermined wavelength, Thereby increasing the efficiency.

Specifically, the LED mask for photodynamic therapy according to the present invention is an LED mask for photodynamic therapy that emits light energy for exciting a light-sensitive substance applied to skin. As shown in FIGS. 1 and 2, And a plurality of LED chips (12) mounted in a form inserted into the mask molding (10).

The mask molded product 10 is molded into a shape that can be worn on a user's face by injection molding or press molding using a mold and the plurality of LED chips 12 are dispersed in the mask molded product 10 .

At this time, the mask molding 10 has a plurality of grooves 11 formed therein, and the LED chips 12 are inserted into the respective grooves 11.

The plurality of LED chips 12 are electrically connected to an external power source and are configured to be operable by being supplied with electric power. The LED chips 12 are operated by applying a low power, for example, an external power of 0.5 mW, (Emits) visible light or near-infrared light having a predetermined wavelength that can be excited.

For example, about 15 to about 200 LED chips 12 can be mounted on the mask molded article 10, and the mask molded article 10 containing the cury mix can be mounted on the LED chip 12 in a visible light or a near- Sensitive material is irradiated with light energy dispersed or reflected to the periphery, the light energy absorbed in the cura mix is emitted from the mask molding 10 and is irradiated to the photosensitive material, Sensitive photoactive material).

Accordingly, it is possible to increase the effect of photodynamic therapy according to the penetration of the photosensitive material into the skin despite the use of the LED chip consuming low power compared to the conventional LED mask.

To this end, the mask molded article 10 is prepared by uniformly mixing 0.1 to 10% of cura mix with a general plastic bead in a weight ratio.

That is, as mentioned above, the mask molded article 10 is molded from a composite composition (or a curacomics composite plastic material) formed by mixing a plastic material and a cura mix, and the composite composition includes 90 to 99.9% by weight of a plastic material 0.1 to 10% by weight of curamax are mixed together.

If the ratio of the cura mix is less than 0.1 wt%, it is difficult to obtain a further active effect of the photosensitive material. If the cura mix is more than 10 wt%, it is difficult to maintain the shape of the mask molding.

The curacomics can be safely used as harmless minerals that can be consumed as foods. Specific examples of the curacomics include sodium (Na), magnesium (Mg), aluminum (Al), silicon (Si), phosphorus (P) , Potassium (K), calcium (Ca), titanium (Ti), iron (Fe), cobalt (Co), zinc (Zn), strontium (Sr), yttrium (Y), zirconium (Zr), molybdenum (Ba), lanthanum (La), cerium (Ce), praseodymium (Pr), thorium (Th) and chlorine (Cl).

The mineral composite, that is, the cura mix, is prepared as a composite of 35 to 60% by weight of silicon (Si) and 40 to 65% by weight of a mineral additive, and the mineral additive is a mineral component other than silicon (Si) (Al), phosphorus (P), sulfur (S), potassium (K), calcium (Ca), titanium (Ti), iron (Fe), cobalt (Sr), yttrium (Y), zirconium (Zr), molybdenum (Mo), barium (Ba), lanthanum (La), cerium (Ce), praseodymium (Pr) And chlorine (Cl).

The plastic material may be any general plastic material. For example, the plastic material may be any one selected from the group consisting of polyethylene, polypropylene, silicone plastic (silicone rubber), polycarbonate and polyester, .

As an LED mask for photodynamic therapy according to the present invention, it is also possible to manufacture an LED mask using a mask sheet portion 20 of a cotton fabric material in addition to the LED mask using the plastic molded article 10 .

Referring to FIG. 3, the LED mask for photodynamic therapy according to the present invention includes a mask sheet portion 20 manufactured using a coating agent or adhesive material mixed with the cura mix (mineral composite), and a mask sheet portion 20 And a plurality of LED chips 25 attached to the LED chip 25.

Specifically, the mask sheet portion 20 is formed of a first mask sheet 21 and a second mask sheet 22 adhered to each other by using a coating composition for coating formed by mixing an adhesive material and a mineral composite, The first and second mask sheets 21 and 22 are formed by cutting a fabric material such as a fabric made of cotton or mixed yarn into a form that can be worn on the user's face.

The composite composition may be prepared by mixing 90 to 99.9% by weight of an adhesive material and 0.1 to 10% by weight of a mineral composite.

As described above, the above-mentioned mineral composite is composed of a mixture of 35 to 60% by weight of silicon (Si) and 40 to 65% by weight of a mineral additive.

The adhesive material may be any material as long as it adheres the first and second mask sheets 21 and 22 and at the same time does not interfere with the property of increasing the photoactive efficiency of the photosensitive material upon irradiation of light energy. A mixture of any one or two or more selected from the group consisting of polyvinylidenefluoride (PVdF), styrene butadiene rubber (SBR), polyvinyl alcohol (PVA), and Teflon (PTFE) is used.

The plurality of LED chips 25 are disposed on one side of the mask sheet portion 20 in a dispersed manner. Specifically, a plurality of holes 23 are formed in the first mask sheet 21 facing the user's face when worn, and the LED chips 25 are fixedly inserted into the respective holes 23 .

The LED chip 25 is electrically connected to an external power source and is configured to be operable by receiving power. When the external power source is applied, the LED chip 25 oscillates light for exciting a photosensitive material separately applied to the skin by the user.

At this time, the mineral composite contained in the composite composition applied in the mask sheet portion 20 receives and absorbs the light energy dispersed or reflected to the periphery of the LED light irradiated to the light-sensitive material. At this time, From the composite composition is irradiated to the photosensitive material to increase the photoactive efficiency of the photosensitive material.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to the following examples.

Example One

1% by weight of cureamics was uniformly mixed with 99% by weight of polyethylene (PE) beads to prepare a cure mix composite plastic material, and then the mold was press molded using a mold. The molded moldings consumed 0.5 mW 50 LED chips were mounted to fabricate a LED mask for photodynamic therapy. At this time, the LED chip used an LED chip which simultaneously irradiated light having a wavelength of 400 to 430 nm and light having a wavelength of 660 to 670 nm. The cura mix includes 38.335% by weight of silicon, 2.273% by weight of sodium, 0.357% by weight of magnesium, 7.661% by weight of aluminum, 0.362% by weight of phosphorus, ), 0.396% by weight of potassium (K), 3.518% by weight of potassium (K), 7.075% by weight of calcium (Ca), 0.426% by weight of titanium (Ti), 2.870% 0.189 wt.% Of strontium (Sr), 0.079 wt.% Of yttrium (Y), 0.888 wt.% Of zirconium (Zr), 6.969 wt.% Of molybdenum, 5.619 wt.% Of barium, 0.349 wt. , 4.714 wt% of cerium (Ce), 0.314 wt% of praseodymium (Pr), 0.251 wt% of thorium (Th) and 0.728 wt% of chlorine (Cl).

Example 2

1% by weight of curamax was uniformly mixed with 99% by weight of polypropylene (PP) beads to prepare a curaamic composite plastic material, which was then molded by press molding using a mold, and 0.5 mW was consumed The LED mask for photomechanical treatment was fabricated by attaching 50 LED chips to be operated. At this time, the LED chip is a mixture of an LED chip that emits light having a wavelength of 400 to 430 nm and an LED chip that emits light having a wavelength of 870 to 890 nm. The cura mix used was a cura mix having the same composition as that of Example 1.

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Example 4

1% by weight of Curaamic was uniformly blended with 99% by weight of polyester beads to prepare a curacomics composite plastic material, and then the mold was press molded using a mold. 50 LED chips were mounted to fabricate a LED mask for photodynamic therapy. At this time, the LED chip is a mixture of an LED chip that emits light having a wavelength of 400 to 430 nm and an LED chip that emits light having a wavelength of 660 to 670 nm. The cura mix includes 52.878 wt% of silicon, 2.408 wt% of sodium, 0.403 wt% of magnesium, 9.792 wt% of aluminum, 0.501 wt% of phosphorus, (Fe), 0.576 wt.% Of cobalt (Co), 9.532 wt.% Of cobalt (Co), 0.587 wt.% Of potassium (K), 2.349 wt.% Of potassium (K), 5.387 wt. 0.13% by weight of strontium (Sr), 0.046% by weight of yttrium (Y), 0.543% by weight of zirconium (Zr), 4.698% by weight of molybdenum, 3.313% by weight of barium, 0.216% , 3.044% by weight of cerium (Ce), 0.193% by weight of praseodymium (Pr), 0.131% by weight of thorium (Th) and 0.418% by weight of chlorine (Cl)

Example 5

5% by weight of cura mix was uniformly blended with 95% by weight of polycarbonate beads to prepare a cura mix composite plastic material, and then the mold was press molded using a mold. 50 LED chips were mounted to fabricate a LED mask for photodynamic therapy. At this time, the LED chip used an LED chip which simultaneously irradiated light having a wavelength of 400 to 430 nm and light having a wavelength of 660 to 670 nm. The cura mix used was a cura mix having the same composition as that of Example 1.

Example 6

8% by weight of cureamics was uniformly blended in 92% by weight of polyurethane beads to prepare a cure mix composite plastic material, and then the mold was press molded using a mold. The molded moldings were operated at 0.5 mW 60 LED chips were mounted to fabricate a LED mask for photodynamic therapy. At this time, the LED chip used an LED chip which simultaneously irradiates light having a wavelength of 400 to 430 nm and light having a wavelength of 870 to 890 nm. The cura mix used was a cura mix having the same composition as that of Example 4.

Example 7

A composite composition was prepared by uniformly blending 99% by weight of polyvinyldiproide (PVdF) and 1% by weight of Curamix, and then the two sheets of cotton fabric were adhered using the composite composition to prepare a mask sheet portion. 60 LED chips operating at 0.5 mW in the seat part were dispersed and attached to fabricate an LED mask for photodynamic treatment. At this time, the LED chip used an LED chip which simultaneously irradiates light having a wavelength of 400 to 430 nm and light having a wavelength of 870 to 890 nm. The cura mix used was a cura mix having the same composition as that of Example 4.

Example 8

A composite composition was prepared by uniformly blending 99% by weight of polyvinyl alcohol (PVA) and 1% by weight of Curamax, and then the two sheets of cotton fabric were adhered using the composite composition to prepare a mask sheet portion. And 50 LED chips operating at 0.5 mW were dispersed and attached to fabricate an LED mask for photodynamic treatment. At this time, the LED chip used an LED chip which simultaneously irradiated light having a wavelength of 400 to 430 nm and light having a wavelength of 660 to 670 nm. The cura mix used was a cura mix having the same composition as that of Example 1.

Example 9

A composite composition was prepared by uniformly blending 97% by weight of styrene-butadiene rubber (SBR) and 3% by weight of Curamix, and then the two sheets of cotton fabrics were attached using the composite composition to prepare a mask sheet portion. And 60 LED chips operating at 0.5 mW were dispersed and attached to fabricate an LED mask for photodynamic therapy. At this time, the LED chip used an LED chip which simultaneously irradiates light having a wavelength of 400 to 430 nm and light having a wavelength of 870 to 890 nm. The cura mix used was a cura mix having the same composition as that of Example 4.

Example 10

A composite composition was prepared by uniformly blending 95% by weight of Teflon (PTFE) and 5% by weight of Curamix, and then the two sheets of cotton fabric were attached using the composite composition to prepare a mask sheet portion. We fabricated a LED mask for photomechanical treatment by dispersing 60 LED chips operating at mW. At this time, the LED chip used an LED chip which simultaneously irradiates light having a wavelength of 400 to 430 nm and light having a wavelength of 870 to 890 nm. The cura mix used was a cura mix having the same composition as that of Example 1.

Comparative Example One

Polyester beads were prepared and press molded into molds using molds. LED masks for photomechanical treatment were fabricated by attaching 50 LED chips operating at 0.5 mW to the mask moldings. At this time, the LED chip used an LED chip which simultaneously irradiated light having a wavelength of 400 to 430 nm and light having a wavelength of 660 to 670 nm.

Experimental Example

The LED masks prepared in Examples 1, 2, 4 to 10, and Comparative Example 1 were put on the face of a user coated with a light-sensitive material having the same composition and capacity, The LED chips were operated using a 220V battery as a power source, and the experimental results as shown in Tables 1, 2, 4 to 10, and Table 11 were obtained, respectively.

Tables 1 and 2, Tables 4 to 10 and Table 11 below show the percent reduction of inflammatory lesions and sebum secretion before and after photodynamic therapy using a photosensitizer and an LED mask, respectively.

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As shown in Tables 1 and 2 and Tables 4 to 11, in Examples 1 and 2 and Examples 4 to 10 containing a curamax component as compared to the reduction ratio in the case of using the LED mask of Comparative Example 1 containing no cura mix component Of the LED mask of the present invention. In particular, it was confirmed that the reduction rate in the case of using the LED mask of Example 4 was greatly increased compared to the reduction rate in the case of using the LED mask of Comparative Example 1.

As described above, the LED mask for photodynamic therapy according to the present invention is manufactured by using a plastic material containing a cura mix, thereby making it possible to utilize LED light energy having a predetermined range of wavelengths necessary for exciting a photo- The excited light-sensitive material), thereby improving the therapeutic effect as compared with photodynamic therapy using an existing LED mask.

In addition, by using the above-mentioned cura mix component, it is possible to produce a composite which exhibits an excellent skin treatment treatment effect, and it can contribute to enhance the skin regeneration effect in addition to the skin trouble treatment effect such as acne.

10: mask molding
12: LED chip
20: mask sheet portion
21: first mask sheet
22: second mask sheet
24: Third mask sheet
25: LED chip

Claims

An LED mask for photodynamic therapy that emits light energy to excite a photosensitive material applied to skin,
A mask molding formed by using a composite composition prepared by mixing a plastic material and a mineral composite;
And a plurality of LED chips dispersed in the mask molding and oscillating light for exciting the photosensitive material when external power is applied,
Wherein the mineral compound is a mixture of 35 to 60% by weight of silicon (Si) and 40 to 65% by weight of a mineral additive and the mineral additive is sodium, magnesium, aluminum, (S), potassium (K), calcium (Ca), titanium (Ti), iron (Fe), cobalt (Co), zinc (Zn), strontium (Sr), yttrium (Y), zirconium Wherein the light emitting diode is formed by mixing molybdenum, barium, lanthanum, cerium, praseodymium, thorium and chlorine.

The method according to claim 1,
Wherein the composite composition comprises 90 to 99.9% by weight of a plastic material and 0.1 to 10% by weight of a mineral composite.

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The method according to claim 1 or 2,
Wherein the plastic material is one selected from the group consisting of polyethylene, polypropylene, silicone plastic, polycarbonate, polyester, and polyurethane, or a mixture of two or more selected from the group consisting of polyethylene, polypropylene, silicone plastic, polycarbonate, polyester and polyurethane.

An LED mask for photodynamic therapy that emits light energy to excite a photosensitive material applied to skin,
A mask sheet portion comprising a first mask sheet and a second mask sheet adhered to each other by a composite composition formed by mixing an adhesive material and a mineral composite;
A plurality of LED chips dispersed on one side of the mask sheet portion and emitting light for exciting the photosensitive material when external power is applied;
And a light emitting diode (LED) mask for photodynamic therapy.

The method of claim 6,
Wherein the composite composition comprises 90 to 99.9% by weight of an adhesive material and 0.1 to 10% by weight of a mineral composite.

The method according to claim 6 or 7,
Wherein the mineral composite comprises 35 to 60% by weight of silicon (Si) and 40 to 65% by weight of a mineral additive.

The method of claim 8,
The mineral additive is selected from the group consisting of Na, Mg, Al, P, S, K, Ca, Ti, Fe, (Co), zinc (Zn), strontium (Sr), yttrium (Y), zirconium (Zr), molybdenum (Mo), barium (Ba), lanthanum (La), cerium (Ce), praseodymium (Th), and chlorine (Cl).

The method according to claim 6 or 7,
Wherein the adhesive material is any one selected from the group consisting of polyvinyl difluoride (PVdF), styrene butadiene rubber (SBR), polyvinyl alcohol (PVA), and polytetrafluoroethylene (PTFE) LED mask for photodynamic therapy.