KR101667444B1 - Organic-inorganic hybrid material and method for manufacturing the same - Google Patents

Abstract

An organic / inorganic hybrid material and a method of manufacturing the same are provided. The organic hybrid material includes an organic material in the form of a fiber and an inorganic material mixed in the form of particles in the organic material. The method for producing an organic / inorganic hybrid material includes the steps of forming an organic solution by dissolving an organic material in an organic solvent, dispersing an inorganic material in the organic solution, removing the organic solvent to form an organic mixture, The organic-inorganic hybrid material is placed in a heating rotor and rotated to form an organic hybrid fiber.

Description

TECHNICAL FIELD [0001] The present invention relates to an organic-inorganic hybrid material and a method for manufacturing the hybrid organic-inorganic hybrid material.

The present invention relates to an organic hybrid material and a manufacturing method thereof.

Recently, biodegradable polymers have been used in the medical field. The biodegradable polymer is loaded with a drug or the like to be used for the treatment of external injuries. Since the biodegradable polymer performs only a function of transferring a drug as an organic material, it can be treated only by the drug to be supported, and the kind of the drug is limited. Therefore, its use is limited in medical fields such as bone regeneration to be. Therefore, a new type of material that can be used for various types of wound healing is required.

Korean Registered Patent No. 10-0823895 (published on April 21, 2008) U.S. Patent Application Publication No. 2012-0247156 (published on Apr. 4, 2012)

In order to solve the above problems, the present invention provides an organic / inorganic hybrid material including both an organic material and an inorganic material.

The present invention provides a method for manufacturing an organic hybrid material by a simple process.

Other objects of the present invention will become apparent from the following detailed description and the accompanying drawings.

The organic hybrid material according to embodiments of the present invention includes an organic material in the form of a fiber and an inorganic material mixed in the form of particles in the organic material.

The organic or inorganic hybrid material may have a cotton-like shape.

The organic material may be a biocompatible organic material or a conductive organic material. The biocompatible organic material may be selected from the group consisting of PLA (polylactic acid), PEG (polyethyleneglycol), PEO (polyethylene oxide), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), polyglycolic acid poly (lactic co glycolide), polymethyl methacrylate (PMMA), polypropylene (PP), polystyrene (PS), acrylonitrile butadiene styrene (ABS), beta lactam, polycarbonate, polyhydroxyalkanoate (PHA) 4-hydroxybutyrate, PPF, PEG-DMA, chitosan, chitooligomer, collagen, gelatin, and hyaluronic acid. The conductive organic material may be at least one selected from the group consisting of polyacetylene, polyaniline, polypyrrole, polythiophene, poly sulfur nitride, polyphenylene vinylene, poly (3,4-ethylenedioxythiophene) (PODOT), polystyrene sulfonate (PSS), and modified conductive polymers thereof.

The inorganic material may be a biocompatible inorganic material.

The biocompatible inorganic material may include one or more selected from a bioceramics material, a bioactive glass, and a biocompatible nanoparticle. The bioceramics material may include at least one selected from a calcium phosphate-based compound, alumina, zirconia, silica, zeolite, cordierite, mullite, metal, metal oxide, and magnetic material. The bioactive glass may be selected from the group consisting of Na ₂ O-CaO-SiO ₂ -P ₂ O ₅ glass, MgO-CaO-SiO ₂ -P ₂ O ₅ glass, CaO-SiO ₂ glass, ceravital ), Cerabone, and bioverit. ≪ / RTI > The biocompatible nanoparticles may include at least one selected from a metal material, a metal oxide material, and a magnetic material.

The fibers may have a diameter of 10 nm to 10 μm, and the particles may have a diameter of 1 nm to 1 μm.

A method of manufacturing an organic-inorganic hybrid material according to embodiments of the present invention includes the steps of forming an organic solution by dissolving an organic material in an organic solvent, dispersing an inorganic material in the organic solution, Forming a mixture, and placing the organic-inorganic hybrid mixture in a heating rotor and rotating the inorganic hybrid fiber to form an organic hybrid fiber.

The method of manufacturing the organic / inorganic hybrid material may further include forming the organic / inorganic hybrid cotton by collecting the organic / inorganic hybrid fibers.

The organic-inorganic hybrid mixture may have a gel form.

According to embodiments of the present invention, an organic hybrid material including an inorganic material mixed in the form of particles in a fibrous organic material can be produced. In addition, a simple process using a centrifugal spinning method can easily produce an organic / inorganic hybride material in a fiber form and a cotton form. Various organic and inorganic hybrid materials can be manufactured using various organic materials and inorganic materials. The organic / inorganic hybrid material can be applied to various fields such as medical field, filter material field, sensor material field, battery material field, electrochemical field, catalytic material field, energy application field, and the like.

FIG. 1 is a flowchart illustrating a method of manufacturing an organic / inorganic hybrid material according to an embodiment of the present invention.
2 schematically shows an apparatus for producing an organic / inorganic hybrid material according to an embodiment of the present invention.
Figure 3 shows an organic / inorganic hybrid cotton fabric prepared according to embodiments of the present invention.
FIG. 4 shows Fourier transform infrared spectroscopy (FT-IR) results of an organic hybrid cotton according to an embodiment of the present invention.
FIG. 5A shows an FESEM (Field Emission Scanning Electron Microscopy) image of an organic / inorganic hybrid cotton according to an embodiment of the present invention, FIG. 5B shows an EDS (Energy Dispersive X-ray Spectroscopy) result of the organic hybrid cotton of FIG. .
FIG. 6 shows the result of applying the organic / inorganic hybrid cotton according to an embodiment of the present invention to human osteoblasts.

Hereinafter, the present invention will be described in detail with reference to examples. The objects, features and advantages of the present invention will be easily understood by the following embodiments. The present invention is not limited to the embodiments described herein, but may be embodied in other forms. The embodiments disclosed herein are provided so that the disclosure may be thorough and complete, and that those skilled in the art will be able to convey the spirit of the invention to those skilled in the art. Therefore, the present invention should not be limited by the following examples.

FIG. 1 is a flowchart illustrating a method of manufacturing an organic / inorganic hybrid material according to an embodiment of the present invention.

Referring to FIG. 1, the method for producing an organic-inorganic hybrid material includes forming an organic solution (S11), an inorganic material dispersing step (S12), a organic solvent mixture forming step (S13), and an organic hybrid fiber forming step ).

The organic material is dissolved in an organic solvent to form an organic solution (S11).

The organic material may be biocompatible The organic material may be a biocompatible organic material or a conductive organic material. The biocompatible organic material may be selected from the group consisting of PLA (polylactic acid), PEG (polyethyleneglycol), PEO (polyethylene oxide), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), polyglycolic acid poly (lactic co glycolide), polymethyl methacrylate (PMMA), polypropylene (PP), polystyrene (PS), acrylonitrile butadiene styrene (ABS), beta lactam, polycarbonate, polyhydroxyalkanoate (PHA) 4-hydroxybutyrate, PPF, PEG-DMA, chitosan, chitooligomer, collagen, gelatin, and hyaluronic acid. The conductive organic material may be at least one selected from the group consisting of polyacetylene, polyaniline, polypyrrole, polythiophene, poly sulfur nitride, polyphenylene vinylene, poly (3,4-ethylenedioxythiophene) (PODOT), polystyrene sulfonate (PSS), and modified conductive polymers thereof.

The organic solvent may be a solvent capable of dissolving the organic material, such as chloroform.

The inorganic material is dispersed in the organic solution (S12).

The inorganic material may be a biocompatible inorganic material. The biocompatible inorganic material may include one or more selected from a bioceramics material, a bioactive glass, and a biocompatible nanoparticle.

The bioceramics material may include at least one selected from a calcium phosphate-based compound, alumina, zirconia, silica, zeolite, cordierite, mullite, metal, metal oxide, and magnetic material. The calcium phosphate compound is similar to a bone component in the human body, and the alumina is excellent in mechanical properties and corrosion resistance, and can be used as a bio-structural ceramic. The zirconia has mechanical, thermal and chemical stability as a biocompatible material, and the zeolite is safe for the human digestive system. The zeolite is excellent in adsorption property and ion exchange ability Can be mixed with a calcium phosphate based compound to be used for an implant or the like. The cordierite can be used as a bioactive material having heat resistance and impact resistance, and mullite can be used as a bioactive material contributing to erosion resistance, oxidation resistance, and stability.

The bioactive glass may be selected from the group consisting of Na ₂ O-CaO-SiO ₂ -P ₂ O ₅ glass, MgO-CaO-SiO ₂ -P ₂ O ₅ glass, CaO-SiO ₂ glass, ceravital ), Cerabone, and bioverit. ≪ / RTI > Wherein the ceravital is a crystallized glass including hydroxyapatite (HAP), the cerabol is a crystallized glass including hydroxyapatite and wollastonite, the biovert is hydroxyapatite and phlogophite, .

The biocompatible nanoparticles may include at least one selected from a metal material, a metal oxide material, and a magnetic material. When catalyst particles such as TiO ₂ , ZnO, SnO ₂ , WO ₃ , ZrO ₂ , and Cd are used as the nanoparticles, various kinds of gases can be sucked depending on porosity.

The inorganic material may be contained at a weight ratio within a range that can be dispersed in the organic material. If the inorganic material is contained in excess of the above range, the inorganic material may be unevenly dispersed in the organic solution and may not be uniformly present in the process of being precipitated and formed into a fiber form, You can stop the hole.

The organic solvent may be further added so that the inorganic material can be uniformly dispersed in the organic solution. Alternatively, the organic solution may be stirred to form a vortex or dispersed by ultrasonic treatment.

The organic solvent is removed to form an organic-inorganic mixture (S13).

The organic solvent is volatilized or heated to be removed by evaporation. At this time, the organic-inorganic hybrid material in which the inorganic material is dispersed is formed. The organic-inorganic hybrid mixture may have a gel form.

The organic-inorganic hybrid mixture is placed in a heating rotor and rotated to form an organic hybrid fiber (S14).

The organic / inorganic hybrid fibers may have a diameter of 10 nm to 10 탆. The inorganic material may be contained in the organic hybrid fiber in the form of particles. The particles may have a diameter of 1 nm to 1 탆.

The organic / inorganic hybrid fibers may be gathered in the formation process to form an organic hybrid cotton.

According to the embodiments of the present invention, it is possible to easily produce organic / inorganic hybrid fibers and inorganic / organic hybrid cotton containing both organic and inorganic materials by a simple process using a centrifugal spinning method. In addition, the ratio (weight ratio) of the organic material to the inorganic material in the organic / inorganic hybrid material can be easily controlled.

A variety of organic and inorganic hybrid materials can be manufactured using various organic materials and inorganic materials. For example, a biocompatible material and a biocompatible material can be used to produce a medical hygiene cotton for medical treatment such as wound healing and first aid treatment. The organic / inorganic hybrid cotton can be easily modified and used in various types of wound treatments, and harmful substances generated in wound areas can be absorbed and removed by capillary action. In addition, the organic / inorganic hybrid cotton prepared using HAP, which is a constituent of bone, can be used for bones-related wounds and can promote bone regeneration.

The rate of decomposition in and out of the living body can be controlled by varying the type and composition of the organic material. For example, PLA, which is slow in biodegradation rate, can be mixed with PGA to regulate the rate of its degradation, which can then be slowly degraded to the body's recovery rate after acting as a support to which the cells of the body can grow .

The organic / inorganic hybrid cotton may serve as a carrier through a space between the fiber and the fiber network, and may be used as a drug and a gene carrier. The drug may include various drugs such as poorly soluble drugs, water-soluble drugs, blood coagulants such as kaolin, anti-cancer drugs such as doxorubicin and paclitaxol, and the like.

Organic hybrid cotton prepared by using conductive polymer can be applied to filter material field by controlling fiber diameter and cotton density and can also be applied to sensor material field for judging infection or contamination using suitable sensor material. , A battery material field, an electrochemical field, a catalyst material field, and an energy application field.

2 schematically shows an apparatus for producing an organic / inorganic hybrid material according to an embodiment of the present invention.

Referring to FIG. 2, the manufacturing apparatus 10 may include a heating rotor 11 and an outer wall 12. When the organic-inorganic hybrid mixture is placed in the center of the heating rotor and rotated while heating, the organic material mixed with the inorganic material in the meshes of the heating rotor 11 is centrifugally pulled out into the fiber form, To thereby form a hybrid fiber (F). The organic / inorganic hybrid fibers F may include an organic material OF in a fibrous form and an inorganic material IP mixed in a particulate form in the organic material OF. The diameter of the organic / inorganic hybrid fibers F formed by adjusting the rotating speed (rpm) of the heating rotor 11 and the mesh size can be adjusted.

The organic non-aqueous mixture can be continuously supplied to the center of the heating rotor 11, whereby the organic hybrid fiber F can be continuously formed. The organic / inorganic hybrid fibers F may be piled on the outer wall 12 to form a cotton-like organic / inorganic hybrid material. Thus, by the centrifugal spinning method using a heating rotor, a fibrous type and cotton-like organic / inorganic hybrid material can be easily formed.

Example  One

3 g of PLA (organic material) was completely dissolved in 10 ml of chloroform (organic solvent) over a sufficient time to form an organic solution, and 0.2 g of HAP (inorganic material) was uniformly dispersed in the organic solution. The chloroform was volatilized to form a gel-like PLA-HAP mixture (organic mixture). The PLA-HAP fiber (organic hybrid fiber) was discharged through the hole in the wall of the heating rotor, and the PLA-HAP fiber (organic hybrid fiber) ). The PLA-HAP fibers were collected to form PLA-HAP cotton (organic hybrid cotton).

Example  2

3 g of PLA was completely dissolved in 10 ml of chloroform for a sufficient time to form an organic solution, and 0.4 g of HAP was uniformly dispersed in the organic solution. The chloroform was volatilized to form a gel-like PLA-HAP mixture. The PLA-HAP mixture was rapidly rotated while being heated in a heating rotor, and the PLA-HAP fiber was discharged through the perforated hole in the wall of the heating rotor to be formed on the outer wall. The PLA-HAP fibers were collected and PLA-HAP cotton was formed.

Example  3

3 g of PLA was completely dissolved in 10 ml of chloroform for a sufficient time to form an organic solution, and 0.8 g of HAP was uniformly dispersed in the organic solution. The chloroform was volatilized to form a gel-like PLA-HAP mixture. The PLA-HAP mixture was rapidly rotated while being heated in a heating rotor, and the PLA-HAP fiber was discharged through the perforated hole in the wall of the heating rotor to be formed on the outer wall. The PLA-HAP fibers were collected and PLA-HAP cotton was formed.

Figure 3 shows an organic / inorganic hybrid cotton fabric prepared according to embodiments of the present invention. 3, HAP-PLA cotton (Example 1) mixed with pure PLA cotton, HAP mixed at a weight ratio of 6.7% (Example 1), HAP-PLA cotton mixed with HAP at a weight ratio of 13.3% (Example 2) And HAP-PLA cotton mixed with HAP at a weight ratio of 26.7% (Example 3).

FIG. 4 shows Fourier transform infrared spectroscopy (FT-IR) results of an organic hybrid cotton according to an embodiment of the present invention. Referring to FIG. 4, it can be seen that the organic / inorganic hybrid cotton has no change of functional groups because the characteristics of the polymer are not modified.

FIG. 5A shows an FESEM (Field Emission Scanning Electron Microscopy) image of an organic / inorganic hybrid cotton according to an embodiment of the present invention, FIG. 5B shows an EDS (Energy Dispersive X-ray Spectroscopy) result of the organic hybrid cotton of FIG. . Referring to FIGS. 5A and 5B, it can be seen that the organic hybrid cotton has calcium (Ca) and phosphate (P) present in the fibers, so that HAP is mixed in the fibers.

FIG. 6 shows the result of applying the organic / inorganic hybrid cotton according to an embodiment of the present invention to human osteoblasts. Referring to FIG. 6, it can be confirmed that human osteocytes grow well around the human osteocytes when applied to the human osteocytes, and that in the growth of human osteocytes, It can be seen that there is no toxicity.

Hereinafter, specific embodiments of the present invention have been described. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

10: Manufacture of hybrid materials
11: heating rotor 12: outer wall
F: Organic hybrid fiber
OF: Organic material in fiber form IP: Inorganic material in particle form

Claims (11)

Organic materials in the form of fibers; And
Organic hybrid fibers comprising an inorganic material mixed in particle form in the organic material,
Wherein the organic / inorganic hybrid material is formed by rotating a gel-like organic / inorganic hybrid mixture in a heating rotor. The method according to claim 1,
Wherein the organic / inorganic hybrid material has a cotton-like shape in which the organic / inorganic hybrid fibers are gathered. The method according to claim 1,
Wherein the organic material is a biocompatible organic material or a conductive organic material. The method of claim 3,
The biocompatible organic material may be selected from the group consisting of PLA (polylactic acid), PEG (polyethyleneglycol), PEO (polyethylene oxide), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), polyglycolic acid poly (lactic co glycolide), polymethyl methacrylate (PMMA), polypropylene (PP), polystyrene (PS), acrylonitrile butadiene styrene (ABS), beta lactam, polycarbonate, polyhydroxyalkanoate (PHA) 4-hydroxybutyrate, PPF, PEG-DMA, chitosan, chitooligomer, collagen, gelatin, and hyaluronic acid,
The conductive organic material may be at least one selected from the group consisting of polyacetylene, polyaniline, polypyrrole, polythiophene, poly sulfur nitride, polyphenylene vinylene, poly (3,4-ethylenedioxythiophene) (PODOT), polystyrene sulfonate (PSS), and modified conductive polymers thereof. The method according to claim 1,
Wherein the inorganic material is a biocompatible inorganic material. 6. The method of claim 5,
Wherein the biocompatible inorganic material comprises at least one selected from a bioceramics material, a bioactive glass, and a biocompatible nanoparticle. The method according to claim 6,
Wherein the bioceramics material comprises at least one selected from a calcium phosphate-based compound, alumina, zirconia, silica, zeolite, cordierite, mullite, metal, metal oxide,
The bioactive glass may be selected from the group consisting of Na ₂ O-CaO-SiO ₂ -P ₂ O ₅ glass, MgO-CaO-SiO ₂ -P ₂ O ₅ glass, CaO-SiO ₂ glass, ceravital ), A cerabone, and a bioverit,
Wherein the biocompatible nanoparticle comprises at least one selected from a metal material, a metal oxide material, and a magnetic material. The method according to claim 1,
Wherein the fibers have a diameter of 10 nm to 10 mu m and the particles have a diameter of 1 nm to 1 mu m. Dissolving the organic material in an organic solvent to form an organic solution;
Dispersing the inorganic material in the organic solution;
Removing the organic solvent to form a gel-like organic-inorganic hybrid mixture;
Adding the organic-inorganic hybrid mixture to a heating rotor to produce an organic hybrid fiber; And
And collecting the organic / inorganic hybrid fibers to form an organic / inorganic hybrid cotton.
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