KR101655233B1 - Multi-type stand for separating magnetic particles - Google Patents

Multi-type stand for separating magnetic particles Download PDF

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Publication number
KR101655233B1
KR101655233B1 KR1020150139630A KR20150139630A KR101655233B1 KR 101655233 B1 KR101655233 B1 KR 101655233B1 KR 1020150139630 A KR1020150139630 A KR 1020150139630A KR 20150139630 A KR20150139630 A KR 20150139630A KR 101655233 B1 KR101655233 B1 KR 101655233B1
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South Korea
Prior art keywords
magnetic
rack
stand
particle separation
tube
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KR1020150139630A
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Korean (ko)
Inventor
유나경
김평래
이희준
최고은
김해진
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주식회사 셀레믹스
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

The magnetic array support 140 is vertically coupled to the upper main rack 110 and the lower plate 150 and then the first side sub-stand rack 120 and the second side sub-stand rack 120 are mounted on both ends of the longitudinal direction Ld of the fastening body. In the multi-type magnetic particle separation stand 100 formed by coupling the second side sub-stand rack 130,
In the upper main rack 110, downwardly-inserted tube holes 112 of an M (row) x 2 (column) structure (M is a natural number of 2 or more)
The magnetic body array support 140 includes M support body 141 and M support body 141 in which M number of through holes spaced in the longitudinal direction Ld are formed to accommodate M compound magnetic bodies 142 in respective through holes There is provided a multi-type magnetic particle separation stand that provides a structure that can be used as a magnetic particle separation stand.

Description

[0001] The present invention relates to a multi-type stand for separating magnetic particles,

The present invention relates to a multi-type magnetic particle separation stand, and more particularly, to a multi-type magnetic particle separation stand for efficiently extracting magnetic particles from a suspension containing magnetized particles.

Magnetic particles have been used in analytical procedures to measure analytes in immunoassays and other genetic tests. The presence of the analyte and / or its amount can be determined from the formation of aggregates and / or from the amount of such formed aggregates.

In immunoassays and other tests, the use of magnetic particles such as magnetic beads as reagents in various embodiments has been developed and used. Due to the presence of the magnetic portion found in the bead, the bead can be separated from the suspension by applying a magnetic force, and the nucleic acid, protein, cell, etc. can be separated and purified using the bead.

A plurality of apparatuses for separating magnetic particles from existing suspensions have been provided, but the suspension tubes used are limited to those having a single diameter, or the magnetic force provided from the magnetic bodies is limited to external factors such as the distance from the suspension tube There has been a limit in that the cohesive force for the magnetic particles by the magnetic body is lowered.

A problem to be solved by the present invention is to provide a multi-type magnetic particle separation stand capable of accommodating suspension tubes of various sizes and further improving flocculation performance using magnetic force for magnetic particles mixed in a suspension in a suspension tube .

According to one aspect of the present invention, the magnetic array support is coupled to the upper main rack and the lower plate respectively, and then the first sub-stand rack and the second side sub- There is provided a multi-type magnetic particle separation stand in which a stand rack is formed by being fastened. In this case, the upper main rack has a downwardly inserted tube hole of M (row) x 2 (column) structure (M is a natural number of 2 or more), and the magnetic array support is separated from the support body and the support body in the longitudinal direction Ld M holes are formed so that M composite magnetic bodies can be accommodated in the respective through holes.

At this time, each compound magnetic body is composed of one bar-shaped magnetic body at the center and two plate-type magnetic bodies provided at both ends of the bar-shaped magnetic body at the center thereof to be exposed to the outside, so that they can have a triple bond structure by magnetic force. The total number of the plate-like magnetic bodies formed on the magnetic-matrix array support may be equal to the number of the downwardly-inserted tube holes by M × 2.

Further, each plate-type magnetic body is matched one-to-one with a suspension tube inserted into each of the downwardly inserted tube holes of the M (row) x 2 (column) structure, so that the angles of the magnetic particles contained in the suspension in each matched suspension tube Thereby providing a magnetic force of the compound magnetic body.

Also, in the present invention, the rod-shaped magnetic substance and the plate-like magnetic substance constituting the compound magnetic body may be formed of a Neodymium-Iron-Boron Magnet.

The thickness of the composite magnetic body is not limited even when all of the covers of the suspension tube inserted into the downwardly inserted tube holes formed in a pair in the width direction Wd in the main plate body placed on the upper portion of the magnetic- Or may be formed without a thickness.

Further, the first side sub-stand rack includes a first side plate main body having a coupling groove for coupling with the upper main rack, the magnetic-matrix array support, and the lower plate; And at least one first side insertion tube hole formed in the first side plate body for receiving the large capacity suspension tube. Two of the first side-insert tube holes may be symmetrically formed with respect to the vertical center line c of the first side plate body.

In addition, the second side sub-stand rack includes the second side plate body and the second side insert tube hole in the same structure as the first side sub-stand rack, and the diameter of the second side insert tube hole is smaller than the diameter of the first side insert tube May be formed to be smaller than or equal to the diameter of the hole.

Also, the large-capacity suspension tube inserted into the first side-inserted tube hole and the second side-inserted tube hole is inserted in a direction orthogonal to the insertion direction of the suspension tube into the lower insertion-type tube hole, and the left or right side And a magnetic field generated by a plurality of compound magnetic bodies disposed in the first magnetic layer.

The sizes of the downward insertion tube hole, the first side insertion tube hole and the second side insertion tube hole are such that the capacity of the suspension tube inserted into each hole is 20 to 2 ml, 5 ml to 50 ml, and 1 ml to 15 ml .

The upper main rack is composed of a multi-rack body including a total of M 占 2 downward insertion tube holes, and two rows extending in the widthwise direction (Wd) beyond the thickness of the bar- In the direction Ld, M downwardly-inserted tube holes are arranged in a row, and may have a structure including a total of Mx 2 downwardly-inserted tube holes.

In one embodiment of the present invention, the multi-rack body may further include a thin film adhesion film portion formed by being padded on the lower surface of the multi-rack body. The adhered film portion is formed with a pore region having the same diameter as the holes of the downwardly inserted tube holes on the upper and lower overlapping positions of the respective downwardly inserted tube holes of the multi-rack body, and a contact protrusion protruding inwardly of each pore region may be formed have.

In another embodiment of the present invention, the lower surface of the multi-rack body may be provided with a contact protrusion protruding inwardly of the respective lower insertion tube holes.

Each of the contact protrusions has a plurality of protruding ends in a direction toward a joining face where the multi-rack main body and the magnetic-matrix array support abuts, and the magnetic-field arrays, which are fastened to the lower portion of the upper main multi- The suspension tube can be brought into close contact with the composite magnetic body inside the support.

In addition, when the tube diameters are different from each other in order to make the capacity of the suspension tube inserted into the downwardly inserted tube hole different, the respective attachment projections can firmly fix suspension tubes of different sizes to the respective downwardly inserted tube holes, - Suspension tubes of different sizes can be brought into close contact with the composite magnetic body inside the magnetic body array support fastened to the bottom of the rack.

The multi-type magnetic particle separation stand according to the embodiment of the present invention improves the cohesion performance by using the magnetic force for the magnetic particles mixed in the suspension inside the suspension tube by using the compound magnetic body having the triple bond structure formed of Neodymium magnet .

In addition, the multi-type magnetic particle separation stand according to another embodiment of the present invention not only provides a variable-structure tube hole structure for using a suspension tube of various sizes, but also provides a structure for closely contacting the magnetic tube with the suspension tube Thereby providing an effect of improving separation performance for magnetic particles.

In addition, the multi-type magnetic particle separating stand according to another embodiment of the present invention can be used not only for the upper main multi-rack corresponding to the upper surface but also for accommodating the suspension tube using the side sub- By arranging the tube holes having different sizes, not only the suspension tubes from the low capacity to the large capacity can be accommodated in terms of relative capacity, but also the magnetic force provided from the magnetic body can be sufficiently provided even when accommodating the large capacity suspension tube.

1 is a perspective view showing a multi-type magnetic particle separation stand according to an embodiment of the present invention;
FIG. 2 is a view showing the structure of the upper main multi-rack among the multi-type magnetic particle separation stand of FIG. 1; FIG.
Fig. 3 is a view for explaining a first side sub-stand rack and a second side sub-stand rack of the multi-type magnetic particle separation stand of Fig. 1; Fig.
Figure 4 is a view of a magnetic array support in the multi-type magnetic particle separation stand of Figure 1;
5 is a plan view showing a lower plate of the multi-type magnetic particle separation stand of FIG.
6 is a view showing that magnetic particles in a suspension tube are separated by a plurality of composite magnetic bodies of a magnetic array support constituting the multi-type magnetic particle separation stand of FIG.
7 is a view showing a multi-type magnetic particle separation stand actually manufactured according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a detailed description of preferred embodiments of the present invention will be given with reference to the accompanying drawings. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

1 is a perspective view showing a multi-type magnetic particle separation stand 100 according to an embodiment of the present invention. 2 is a view for explaining the structure of the upper main multi-rack 110 among the multi-type magnetic particle separating stand 100 of FIG. 1. FIG. 2B shows the lower surface of the closely-packed film portion 111a of the upper main multi-rack 110 and FIG. 2C shows the lower surface of the multi-rack main body 111 and the closely- 111a are coupled with each other.

FIG. 3 is a front view of a first side sub-stand rack 120 and a second side sub-stand rack 130 of the multi-type magnetic particle separation stand 100 of FIG.

4A is a side view of the magnetic array support 140 and FIG. 4B is a side view of the magnetic array support 140 in the multi-type magnetic particle separation stand 100 of FIG. 1. FIG. 4C is a plan view of the compound magnet 142. FIG.

5 is a plan view showing the lower plate 150 of the multi-type magnetic particle separation stand 100 of FIG.

1 to 5, the multi-type magnetic particle separating stand 100 includes an upper main multi-rack 110, a first side sub-stand-rack 110, A magnetic substrate array 120, a second side sub-stand-rack 130, a magnetic array support 140, and a bottom plate 150, The liquid and the magnetic particles can be separated from the suspension in which the magnetic particles are mixed by using the magnetic force of the composite magnetic body 142.

The magnetic particles to be separated in the present invention are not particularly limited as long as they are magnetic materials and include magnetic beads, magnetic nanoparticles, and the like.

The upper main multi-rack 110 may include a multi-rack body 111 and a lower insertion tube hole 112. In this case, the multi-rack body 111 has M downwardly-inserted tube holes 112 arranged in the longitudinal direction Ld, and two downwardly-inserted tube holes 112 spaced apart in the widthwise direction Wd (M is a natural number greater than or equal to 2). The number of the downwardly inserted tube holes 112 shown in FIG. 1 is one example for explanation, and the scope of the present invention is not limited thereto.

Referring to FIG. 2, the multi-rack body 111 may further include a close-contact film portion 111a padded on the lower surface thereof. Here, the adhesive film portion 111a is attached to the lower surface of the multi-rack body 111 as a thin film of a flexible material, and has a downwardly inserted tube hole 112 at a position overlapping with each of the downwardly inserted tube holes 112, And a contact protrusion 112a protruding inward from each of the pore regions having the same diameter. In an embodiment of the present invention, the adhesion film portion may be a plastic material, for example, an acrylic plate.

More specifically, the contact protrusions 112a may have a plurality of protruding ends in a direction toward a joining surface where the multi-rack body 111 and the magnetic-matrix array support 140 abut on a horizontal plane. The contact protrusions 112a are fastened to the lower portion of the upper main multi-rack 110 when the suspension tubes t1, t2, t3 capable of differentially forming the respective downwardly-inserted tube holes 112 are inserted And functions to closely contact the suspension tubes t1, t2 and t3 with the compound magnetic body 142 inside the magnetic-matrix array support 140. [

In another embodiment of the present invention, the lower surface of the multi-rack body 111 may be provided with a contact protrusion 112a protruding inwardly of the respective lower insertion tube holes 112. [

Due to the structure of the main multi-rack 110 provided with the plurality of contact protrusions 112a having the directional close contact function, the composite magnetic body for the magnetic particles mixed in the suspension inside the suspension tubes t1, t2, It is possible to improve the coagulation performance by using the magnetic force by the magnetic force applying member 142.

The function of holding all of the suspension tubes t1, t2 and t3 inserted into the respective downwardly-inserted tube holes 112 even when the tube diameters of the suspension tubes t1, t2 and t3 are different from each other such that the capacity of the suspension tubes t1, t2, (112a).

More specifically, when the diameter of the suspension tube is smaller than that of the lower insertion tube hole 112, the contact protrusion 112a formed in the puncture region of the adhesive film portion 111a serves to securely fix the suspension tube, Thereby providing a structure in which the tube can be accommodated in the downwardly inserted tube hole 112. On the other hand, the suspension tubes t1, t2 and t3 are formed of a flexible material so that the contact protrusions 112a can be applied without difficulty even when the diameter of the suspension tube is larger than the downwardly-inserted tube hole 112. [

The first side sub-stand rack 120 and the second side sub-stand rack 130 are constructed such that the magnetic array support 140 is vertically fastened to the upper main rack 110 and the lower plate 150, respectively, And one at each end in the longitudinal direction Ld of the fastener.

First, the first side sub-stand rack 120 includes a first side plate body 121 and a first side insertable tube hole 122.

The first side plate body 121 is formed with respective fastening grooves for engaging with the upper main rack 110, the magnetic-matrix array support 140, and the lower plate 150.

The first side plate body 121 may include at least one first side insertion tube hole 122 capable of receiving a large capacity suspension tube t4. The first side-insert tube holes 122 are symmetrically formed with respect to the vertical center line c of the first side plate body 121 to accommodate the large-capacity suspension tube t4. The diameters of the symmetrical first side insertable tube holes 122 may be equal to or different from each other.

The second side sub-stand rack 130 also includes a second side plate body 131 and a second side insert tube hole 132 to provide a similar structure and configuration to the first side sub- . The diameter of the second side insertable tube hole 132 is formed to be smaller than or equal to the diameter of the first side insertable tube hole 122. In one embodiment of the present invention, a 50 ml suspension tube may be inserted into the first side insertable tube hole 122, and a 15 ml suspension tube may be inserted into the second side insertable tube hole 132.

The large-capacity suspension tube inserted into the first side-insertion tube hole 122 and the second side insertion tube hole 132 is inserted into the lower insertion tube hole 112 of the suspension tube t1, t2, And may be provided with a magnetic force by a plurality of compound magnetic bodies 142 located on the left or right side where the tube length at the time of insertion reaches.

The magnetic body array support 140 includes a composite magnetic body array composed of a support body 141 and a plurality of composite magnetic bodies 142. The support base body 141 is provided with M through holes spaced in the longitudinal direction Ld to provide a structure capable of accommodating M complex magnetic bodies 142 in the respective through holes. )

The composite magnetic body 142 may be composed of one bar-shaped magnetic body 142b at the center and a plate-like magnetic body 142a provided at both ends of the bar-like magnetic body 142b. In the drawing, the cross section of the rod-like magnetic body 142b and the plate-like magnetic body 142a is shown in a circular shape, but the shape is not limited thereto.

The bar-shaped magnetic body 142b and the plate-like magnetic body 142a constituting the composite magnetic body 142 may be, for example, a neodymium-iron-boron magnet. Neodymium magnet is one of the most widely used rare earth magnets on the earth. It is made by alloying neodymium, iron and boron at a ratio of 2: 14: 1 by powder metallurgy. It is the strongest magnet (25 to 50 MGOe). The neodymium magnet is preferably used after being plated with silver or nickel. When the magnetic force of the neodymium magnet is lowered, the magnetic force can be increased again.

The composite magnetic body 142 is composed of one bar-shaped magnetic body 142b at the center and a plate-like magnetic body 142a provided at both ends thereof on the basis of the one bar-like magnetic body 142b. t1, t2, t3, t4) of the magnetic particles.

To prove this effect, a comparative example in which a single cylindrical neodymium magnet having the same diameter as the rod-like magnetic body 142b is machined by the entire length of the composite magnetic body 142 according to the present invention, A composite magnetic body 142 having a triple bond structure according to the present invention was attached to the magnetic-matrix array support 140, respectively, and then a 2-ml suspension tube was tested using a 500-μ magnetic particle suspension. As a result, the reference example according to the present invention showed an agglomeration time for the magnetic particles of 30 seconds to 60 seconds faster than that of the comparative example of 240 seconds. This indicates that the compound magnet 142 having the triple bond structure of the present invention is suitable in a large-scale experiment. The greater the number of samples or the greater the use of magnetic particles in the tube, the greater the savings in time.

The composite magnetic material 142 of the present invention forms a triple bond structure by using polarities N and S of magnetic force generated in the rod-like magnetic body 142b and the plate-like magnetic body 142a, It provides the advantage of maintaining a triple bond structure even without a sieve.

When the multi-type magnetic particle separating stand 100 is constructed by using the plurality of compound magnetic bodies 142 formed by the triple bonding structure, the magnetic particle array supporting stand body 100 can be formed into a single cylindrical shape in the longitudinal direction Ld of the magnetic- It is possible to reduce the weight without lowering the magnetic force.

Each of the composite magnetic bodies 142 is opened by opening the covers of the suspension tubes t1, t2 and t3 inserted into the downwardly inserted tube holes 112 formed in a pair in the width direction Wd in the main plate body 111 For example, 12 mm to 13 mm, so that no collision occurs between them when they are opened (open).

Each of the two plate-like magnetic bodies 142a constituting one composite magnetic body 142 is assigned to one suspension tube t1, t2, t3 inserted into the downwardly inserted tube hole 112. [ That is, as shown in FIG. 1, the suspension tubes t1 and t2 (hereinafter, referred to as " t2 ") which are paired in the width direction Wd and are finally inserted into the 16 downwardly- , t3) are in close contact with the plate-like magnetic bodies 142a of the eight composite magnetic bodies 142.

The upper main multi-rack 110, the first and second side sub-stand racks 120 and 130, the magnetic-matrix array support 140, and the lower plate 150, which constitute the multi-type magnetic particle separation stand 100, May be formed of a transparent acrylic resin, an olefin resin such as PE or PP, a styrene resin such as PS or ABS, or the like.

6 is a view showing that magnetic particles in a suspension tube are separated by a plurality of compound magnetic bodies 142 of a magnetic-matrix array support 140 constituting the multi-type magnetic particle separation stand 100 of FIG. 7 is a view showing that a multi-type magnetic particle separation stand 100 according to an embodiment of the present invention is actually manufactured.

6A shows a state in which the magnetic particles in the suspension tube inserted into the downwardly inserted tube hole 112 of the upper main multi-rack 110 are aggregated with the composite magnetic body 142, The magnetic particle separating apparatus having a structure in which the existing magnetic body is not exposed to the outside is in contrast to the case where the magnetic particles are spread and agglomerated.

5 (b) and 5 (c) show a first side insert tube hole 122 and a second side insert tube hole 132 of the first side sub-stand rack 120, respectively, The magnetic particles in the suspension tube are aggregated with a plurality of composite magnetic bodies 142. It has been found that magnetic particles can be effectively separated even when a large-capacity tube is used.

As described above, preferred embodiments of the present invention have been disclosed in the present specification and drawings, and although specific terms have been used, they have been used only in a general sense to easily describe the technical contents of the present invention and to facilitate understanding of the invention , And are not intended to limit the scope of the present invention. It is to be understood by those skilled in the art that other modifications based on the technical idea of the present invention are possible in addition to the embodiments disclosed herein.

100: Multi-type magnetic particle separation stand
110: upper main multi-rack < RTI ID = 0.0 >
111: Multi-rack body
112: Downward insertion tube hole
120: 1st side sub stand-rack < RTI ID = 0.0 >
121: first side plate body
122: first side insertable tube hole
130: 2nd side sub stand-rack < RTI ID = 0.0 >
131: second side plate body
132: second side insertable tube hole
140: magnetic array support
141: Support body
142: compound magnetic body
150: Lower plate

Claims (15)

The magnetic array support 140 is vertically coupled to the upper main rack 110 and the lower plate 150 and then the first side sub-stand rack 120 and the second side sub-stand rack 120 are mounted on both ends of the longitudinal direction Ld of the fastening body. In the multi-type magnetic particle separation stand 100 formed by coupling the second side sub-stand rack 130,
In the upper main rack 110, downwardly-inserted tube holes 112 of an M (row) x 2 (column) structure (M is a natural number of 2 or more)
The magnetic body array support 140 includes M support body 141 and M support body 141 in which M number of through holes spaced in the longitudinal direction Ld are formed to accommodate M compound magnetic bodies 142 in respective through holes It provides a structure that can be done,
The compound magnetic body 142 is composed of a single rod-shaped magnetic body 142b at the center and two plate-shaped magnetic bodies 142a provided at both ends of the rod-like magnetic body 142b exposed to the outside, and has a triple- However,
The first side sub-stand rack 120 includes a first side plate body 121 having a coupling groove for coupling with the upper main rack 110, the magnetic-matrix array support 140, and the lower plate 150; And
At least one first side insertion tube hole (122) formed in the first side plate body (121) and receiving a large capacity suspension tube (t4); A magnetic particle separation stand of a multi type. The multi-type magnetic particle separation stand according to claim 1, wherein the total number of plate-like magnetic bodies (142a) formed on the magnetic-matrix array support (140) coincides with the number of downwardly-inserted tube holes (112). The magnetic sensor according to claim 2, wherein each plate-like magnetic body (142a)
T2 and t3 which are inserted into the respective downwardly inserted tube holes 112 made of the M (row) x 2 (column) structure, so that each of the matched suspension tubes t1, t2, Type magnetic particle separation stand that provides the magnetic force of the composite magnetic body 142 to the magnetic particles included in the suspension in the magnetic particle separation stand. The multi-type magnetic particle separation stand according to claim 2, wherein the rod-shaped magnetic body (142b) and the plate-like magnetic body (142a) constituting the composite magnetic body (142) are formed of neodymium magnets. The thickness of the composite magnetic body 142 is set such that the thickness of the composite magnetic body 142 is equal to or greater than the thickness of the magnetic body array support 140 in the downwardly inserted tube hole 112 formed as a pair in the width direction Wd in the main plate body 111, The multi-type magnetic particle separation stand is formed to have a thickness free from interference even when all of the covers of the suspension tubes (t1, t2, t3) to be inserted are open. delete [2] The apparatus according to claim 1, wherein the first side insertable tube hole (122)
Two types of magnetic particle separation stands are formed which are symmetrical with respect to the vertical center line (c) of the first side plate body (121). The magnetic array support 140 is vertically coupled to the upper main rack 110 and the lower plate 150 and then the first side sub-stand rack 120 and the second side sub-stand rack 120 are mounted on both ends of the longitudinal direction Ld of the fastening body. In the multi-type magnetic particle separation stand 100 formed by coupling the second side sub-stand rack 130,
In the upper main rack 110, downwardly-inserted tube holes 112 of an M (row) x 2 (column) structure (M is a natural number of 2 or more)
The magnetic body array support 140 includes M support body 141 and M support body 141 in which M number of through holes spaced in the longitudinal direction Ld are formed to accommodate M compound magnetic bodies 142 in respective through holes It provides a structure that can be done,
The compound magnetic body 142 is composed of a single rod-shaped magnetic body 142b at the center and two plate-shaped magnetic bodies 142a provided at both ends of the rod-like magnetic body 142b exposed to the outside, and has a triple- However,
The second side sub-stand rack (130)
Includes a second side plate body (131) and a second side insertion tube hole (132) in the same structure as the first side sub-stand rack (120)
Wherein the diameter of the second side insertable tube hole (132) is smaller than or equal to the diameter of the first side insertable tube hole (122). The system of claim 8, wherein a large capacity suspension tube (t4) is inserted into the first side insertion tube hole (122) and the second side insertion tube hole (132) Type tube hole 112 in the insertion direction and is provided with a magnetic force by a plurality of compound magnetic bodies 142 located on the left or right side where the tube length reaches the length of insertion, Magnetic particle separation stand. The dimensions of the lower insertion tube hole 112, the first side insertion tube hole 122, and the second side insertion tube hole 132 are set such that the capacity of the suspension tube inserted into each hole is 20 [mu] To 2 ml, from 5 ml to 50 ml, and from 1 ml to 15 ml. The apparatus according to claim 1, wherein the upper main rack (110)
Rack body 111 including a total of M × 2 downwardly inserted tube holes 112 and a bar-like magnetic body 142b of the composite magnetic body 142 in the width direction Wd on the multi-rack body 111 M downward insertion tube holes 112 are arranged in a row in the longitudinal direction Ld and a plurality of downward insertion tube holes 112 are formed in the longitudinal direction Ld, Particle separation stand. 12. The multi-rack body according to claim 11,
A thin film adhesion film portion 111a padded on the lower surface of the multi-rack body 111; Further comprising a magnetic particle separation stand of a multi-type. [12] The method according to claim 12,
A punched region having the same diameter as the hole of the downwardly inserted tube hole 112 is formed on the upper and lower overlapping positions with the respective downwardly inserted tube holes 112 of the multi-rack body 111, A multi-type magnetic particle separation stand in which protruded contact protrusions (112a) are formed. [14] The method according to claim 13, wherein each of the contact protrusions (112a)
The suspension tubes t1, t2 and t3 are inserted into the respective lower insertion tube holes 112 with a plurality of protruding ends in the direction toward the joining surface where the multi-rack main body 111 and the magnetic- A magnetic particle separation stand of a multi-type type in which suspension tubes (t1, t2, t3) are brought into close contact with a composite magnetic body (142) inside a magnetic body array support (140) fastened to a lower portion of an upper main multi- 12. The multi-rack body according to claim 11,
Further comprising a contact protrusion (112a) protruding to the inside of each of the downwardly inserted tube holes (112) on the lower surface of the multi-rack body (111).

KR1020150139630A 2015-10-05 2015-10-05 Multi-type stand for separating magnetic particles KR101655233B1 (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003144968A (en) * 2001-11-16 2003-05-20 Jsr Corp Magnetic stand
CN104525291A (en) * 2014-12-24 2015-04-22 科晶（宁波）生物科技有限公司 Test tube frame

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003144968A (en) * 2001-11-16 2003-05-20 Jsr Corp Magnetic stand
CN104525291A (en) * 2014-12-24 2015-04-22 科晶（宁波）生物科技有限公司 Test tube frame

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