KR101643104B1 - Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves - Google Patents
Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves Download PDFInfo
- Publication number
- KR101643104B1 KR101643104B1 KR1020150137644A KR20150137644A KR101643104B1 KR 101643104 B1 KR101643104 B1 KR 101643104B1 KR 1020150137644 A KR1020150137644 A KR 1020150137644A KR 20150137644 A KR20150137644 A KR 20150137644A KR 101643104 B1 KR101643104 B1 KR 101643104B1
- Authority
- KR
- South Korea
- Prior art keywords
- lamb wave
- time
- cortical bone
- unit
- lamb
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0875—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4514—Cartilage
Abstract
As the SGW can be accurately measured by irradiating a time-reversed lamb wave to the cortical bone of the tibia, the cortical bone using the time reversing lamb wave which predicts the bone density of the cortical bone through the propagation velocity of the lamb wave propagating along the cortical bone of the tibia, And a method for predicting bone mineral density.
According to the present invention, since cortical bone mineral density is predicted using harmless ultrasound to the human body, there is no damage such as radiation exposure due to measurement using conventional radiation, so that the human body is relatively safe, It is possible to calculate the propagation speed of a slow guided wave (SGW) signal closely related to the bone density of the cortical bone, and thus it is possible to predict a reliable cortical bone density.
Description
The present invention relates to an apparatus and a method for predicting cortical bone density using a time reversal Lamb wave.
Recently, the number of patients with degenerative osteoporosis is also increasing as the standard of living improves, medicine develops, life expectancy increases, and the elderly population increases.
Degenerative osteoporosis is reported to be caused by osteoporosis in skeletal volume reduced by 10% of the total population in the United States. The annual incidence of osteoporosis-related fractures increases and the annual medical expenses are increasing.
This is because osteoporosis is a very important disease because bone fracture can be caused by a decrease in bone mineral density below the fracture threshold and fracture can be caused even with a small impact and fracture is a major cause of death in the elderly. Therefore, development of a device for measuring the risk of fracture This is a required situation.
To this end, in Korean Patent Registration No. 10-1053438 (filed on August 22, 2009, registered on July 27, 2011, hereinafter referred to as "prior art"), a radioisotope emitting two or more gamma- To measure bone mineral density.
However, since the prior art is required to irradiate high-energy radiation to measure the bone density per unit area, it is inevitable that the patient is exposed to radiation, and a method of accurately measuring the bone density of the cortical bone during the conventional method of diagnosing osteoporosis has not been disclosed There is a problem that accurate diagnosis of osteoporosis is difficult.
SUMMARY OF THE INVENTION It is an object of the present invention to provide a technique for predicting an accurate cortical bone density without using radiation in the diagnosis of osteoporosis.
To achieve this object, there is provided a lamb wave generator for generating a lamb wave from an electrical signal; A lamb wave transmitter for irradiating the tibia with a lamb wave generated by the ram derivative; A lamb wave receiving unit for receiving the lamb wave irradiated by the lamb wave transmitting unit; A converter for converting the Lamb wave received by the Lamb wave receiver into an electrical signal; A signal processing unit for detecting an electrical signal converted by the converting unit, the signal inverting unit inverting a time of the electrical signal received by the converting unit; And an operation unit for calculating the propagation speed of the lamb wave propagated along the cortical bone by analyzing the electrical signal detected by the signal processor and for predicting the bone density of the cortical bone through the propagation speed of the lamb wave propagated along the calculated cortical bone The Lamb wave transmitting unit transmits the time-reversed electric signal to the Lamb wave generating unit by the time inverting unit to generate time-inverted Lamb waves. The Lamb wave transmitting unit irradiates the time-reversed Lamb waves, The bone density of the cortical bone is predicted using the linear relationship between the propagation velocity value of the time-reversed lamb wave propagated along the cortical bone and the bone density value of the cortical bone in proportion to and increasing in amount, The propagation velocity of a first arriving signal (FAS) or the slow guided wave (SGW) Of the propagation velocity.
delete
delete
delete
The apparatus for predicting cortical bone density using the time reversing lamb wave further includes an output unit for outputting a result calculated by the arithmetic unit.
And the lamb wave irradiated from the lamb wave transmitting unit is a single mode lamb wave having a single frequency in the range of 180 to 220 kHz.
On the other hand, a method of predicting cortical bone density includes: an initial lamb wave irradiation step of irradiating a lamb wave generated by a lamb wave generator to a tibia; A first conversion step of receiving a Lamb wave from the Lamb wave receiving unit in the initial Lamb wave irradiation step and converting the Lamb wave into an electrical signal; A time reversing step of receiving the Lamb wave first irradiated to the tibia from the Lamb wave receiving unit and converting the received Lamb wave into an electrical signal, receiving the electrical signal converted by the time reversing unit, and inverting the time; A time reversing Lamb wave generating step of generating the Lamb waves of time reversal from the electrical signals obtained by time-inverting the Lamb wave generator in the time inverting unit; A time inverted lamb wave irradiation step of irradiating the tibia with the time-reversed lamb wave generated by the lamb wave transmitter in the lamb wave generator; A second conversion step of receiving the time reversal Lamb wave from the Lamb wave reception unit and converting the Lamb wave into the electrical signal in the time reversing Lamb wave irradiation step; And a calculation step of calculating a propagation speed of a lamb wave propagated along the cortical bone through the electrical signal converted in the second conversion step, wherein the calculation step comprises: Calculating a propagation speed of the lamb wave propagated along the cortical bone by the calculation unit; And a prediction step of predicting a bone density of the cortical bone using a correlation between the propagation velocity of the lamb wave propagated along the cortical bone calculated in the propagation speed calculation step and the bone density of the cortical bone, Predicting a bone mineral density of the cortical bone using a linear relationship between a propagation velocity value of a time-reversed lamb wave propagated along a cortical bone and a bone mineral density value of the cortical bone in an increasing amount, A propagation velocity of a first arriving signal (FAS) or a slow guided wave (SGW) that first reaches the receiving unit.
In this case, the lamb wave irradiated by the Lamb wave transmitting unit in the initial lamb wave irradiating step may be a single mode lamb wave having a single frequency in the range of 180 to 220 kHz.
delete
delete
The method of predicting cortical bone density using the time reversed lamb wave further includes an output step of outputting a propagation speed of the lamb wave propagated along the cortical bone calculated in the calculating step and a bone density prediction result of the cortical bone.
As described above, the present invention has the following effects.
First, since the cortical bone mineral density is predicted by using the harmless ultrasound to the human body, the human body is comparatively safe because no damage such as radiation exposure is caused by the measurement using the conventional radiation.
Second, by irradiating time-reversed lambs to the tibia, it is possible to calculate the propagation speed of a slow guided wave (SGW) signal, which is closely related to the cortical bone density of the tibia, so that reliable cortical bone density can be predicted.
FIG. 1 is a schematic view of an apparatus for predicting a cortical bone density using a time reversing lamb wave according to an embodiment of the present invention.
FIG. 2 is a time-inverted Lamb wave signal generated by the time inverting unit and the Lamb wave generating unit of the present invention.
3 is a graph showing the propagation speed of a lamb wave propagated along the cortical bone of a tibia sample at different distances between the lamb wave transmitter and the lamb wave receiver.
FIG. 4 is a graph showing the correlation between the propagation speed of the Lamb wave and the bone density of the cortical bone sample, which are time-reversed through the tibia sample.
FIG. 5 is a flowchart illustrating a method of predicting bone density of cortical bone using a time reversal Lamb wave in an embodiment of the present invention.
The preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings, in which the technical parts already known will be omitted or compressed for simplicity of explanation.
<Construction of Prediction Tool for Bone Mineral Density of Cortical bone using time reversal Lamb wave>
FIG. 1 schematically shows an apparatus for predicting a cortical bone density of a cortical bone using a time reversal lamb wave according to an embodiment of the present invention, and FIG. 2 shows a time-reversed Lamb wave signal generated by the time reversal unit and the lamb wave generator of the present invention FIG. 3 is a graph showing the correlation between the propagation velocity of Lamb waves through the tibia sample and the bone density of the cortical bone sample.
The
The
Here, a lamb wave is a waveguide in which a structure propagates along a structure when generating a seismic wave in the structure, and is called a lamb wave or guided ultrasonic wave.
Therefore, the
The Lamb
Here, the lamb wave irradiated from the
At this time, the above range may be variously changed according to the kind of bone to be examined (for example, spongy bone).
The Lamb
The converting
The
The
2, a graph of FIG. 2 (a) is a Lamb wave not inverted in time, which is checked by the best lamb
Here, the SGW, which is closely related to the bone density of the cortical bone, is easily modulated due to other signals received after the FAS and SGW, which makes it difficult to accurately measure the bone density.
Accordingly, the converting
Thereafter, the
The graph of FIG. 2 (c) shows that the
(d) The graph is a frequency spectrum obtained by Fourier transform of the graph. The time reversal ramp has a single frequency of 200 kHz, so that a single-mode Lambertian can be obtained.
That is, the
The
Here, the
The calculating
Here, the propagation speed is a first arriving signal (FAS) or a slow guided wave (SGW).
In the embodiment of the present invention, the
In addition, the
At this time, the
The
<Method of Predicting Bone Mineral Density of Cortical Bones Using Time Inverted Lamb Wave>
FIG. 5 is a flowchart illustrating a method of predicting bone density of cortical bone using a time reversal Lamb wave in an embodiment of the present invention.
The method of predicting cortical bone density using a time reversal Lamb wave according to an embodiment of the present invention may include an initial Lamb wave irradiation step S510, a first transformation step S520, an operation step S530, and an output step S540 have.
1. Initial Lamb wave irradiation step <S510>
In the initial lamb wave irradiation step S510, the lamb
2. First conversion step < S520 >
The first conversion step S520 is a step in which the
3. Time reversal step < S530 >
In the time reversal step S530, the
4. Time reversing lamb wave generation step (S540)
The time reversal lamb wave generation step S540 is a step in which the lamb
5. Time reversing Lamb wave irradiation step (S550)
The time reversal lamb wave irradiation step S550 is a step in which the lamb
That is, in the initial lamb wave irradiation step S510, an electrical signal obtained from the lamb wave irradiated on the initial tibia B is time-reversed to generate a time-reversed lamb wave, and the generated time-reversed lamb wave is irradiated to the tibia B After the completion of the one-time operation, the position of the Lamb
6. Second conversion step < S560 >
The second conversion step S560 is a step in which the
7. Operation step <S570>
The calculation step S570 detects the SGW signal from the electrical signal of the time inverted lamb wave converted by the
The propagation speed calculation step S571 calculates the propagation speed of the time inverted lamb wave propagated along the axial direction of the tibia B by measuring the time at which the
2 to 3, it can be seen that the electrical signal of the time inverted Lamb wave forms a peak of the SGW signal, and the reception of the SGW signal according to the difference in distance between the
The prediction step S572 compares the propagation speed of the lamb wave calculated in the propagation velocity calculation step S571 with the cemented bone density data of the pre-stored tibia sample BS and the propagation velocity data of the lamb wave according to the cortical bone density, ) Of the cortical bone.
Here, the Lamb wave propagation velocity data according to the measured cortical bone density data (that is, the bone density data of the pre-stored tibial sample (BS)) and the cortical bone mineral density are obtained from the cortical bone mineral density of 18 small tibial bone samples (BS) ), Which is measured by irradiating a Lamb wave inverted in time, and will be described with reference to FIG.
4, 18 small tibial bone samples (BS) were prepared, bone mineral density of each cranial bone sample (BS) was measured, and each of the tibial bone samples (BS) was irradiated with a time reversed lamb wave to measure the lamb wave propagation velocity Quot; * " in the graph.
In this case, there is a positive (+) linear correlation between the propagation velocity of the time reversed Lamb wave and the bone density of cortical bone, and the Pearson correlation coefficient r value obtained by the linear regression method is 0.76, It can be seen that the propagation velocity of Lamb waves has a very high linear correlation with the bone density of the cortical bone and the phase velocity of the A0 mode lamb wave indicated by the solid line and the time reversed lamb wave propagated along the tibial axis direction of 18 tibial samples , It can be confirmed that the time reversed lamb wave propagated along the tibial bone sample BS is an A0 mode lamb wave.
That is, the propagation speed of the time reversal lamb wave propagated along the tibia B calculated from the propagation speed calculation step S572 in the estimation step S572 is calculated by multiplying the propagation speed of the time reversal lamb wave with respect to the measured tibia sample BS The bone density of the cortical bone (B) can be predicted by comparing the bone density of the cortical bone with that of the cortical bone.
In other words, it means that it is possible to derive a predetermined regression equation from the correlation between the propagation velocity of the time reversal Lem's wave and the bone density value of the cortical bone in the prediction step S572. Therefore, by measuring the propagation velocity of the time- It is possible to predict the bone density value of the cortical bone.
8. Output step < S580 >
The outputting step S580 is a step of outputting the cortical bone density prediction result value according to the propagation speed value of the time inverted lamb wave propagated along the tibia B in the calculation step S570 and the propagation speed of the
As a result, the present invention uses an induction ultrasound harmless to the human body, unlike the method of measuring bone density, which irradiates high-energy radiation to a patient's measurement site, It is possible to minimize the patient's discomfort and physical damage when measuring the risk of occurrence, and it is possible to calculate the propagation speed of the SGW signal which is closely related to the bone density of the cortical bone of the tibia by irradiating the tibia with a time-
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. And the scope of the present invention should be understood as the following claims and their equivalents.
100: Prediction of bone density of cortical bone using time reversal Lamb wave
110: Lamb wave generating unit
120: Lamb wave transmitter
130: Lamb wave receiver
140:
150: half an hour
160: Signal processor
170:
180: Output section
B: Tibia
BS: Tibia sample
Claims (11)
A lamb wave transmitter for irradiating the tibia with a lamb wave generated by the ram derivative;
A lamb wave receiving unit for receiving the lamb wave irradiated by the lamb wave transmitting unit;
A converter for converting the Lamb wave received by the Lamb wave receiver into an electrical signal;
A time inverting unit for inverting the time of the electric signal received by the converting unit;
A signal processing unit for detecting an electrical signal converted by the conversion unit; And
And an operation unit for analyzing the electrical signal detected by the signal processing unit to calculate the propagation speed of the lamb wave propagated along the cortical bone and for predicting the bone density of the cortical bone through the propagation speed of the lamb wave propagated along the calculated cortical bone, ,
The Lamb wave transmitter transmits a time inverted electrical signal to the Lamb wave generator to generate time-inverted Lamb waves. The Lamb wave transmitter examines the time-reversed Lamb waves in the Lamb wave transmitter,
Wherein the calculation unit estimates the bone density of the cortical bone by using a linear relationship between a propagation velocity value of the time reversed lamb wave propagated along the cortical bone and a bone density value of the cortical bone in proportion to and increasing in amount,
Wherein the propagation velocity is a propagation velocity of a first arriving signal (FAS) or a slow guided wave (SGW) that first arrives at the lamb wave receiving unit. Prediction device.
The apparatus for predicting cortical bone density using the time reversing Lamb wave includes:
And an output unit for outputting a result calculated by the calculation unit. The apparatus for predicting bone density of cortical bone using time reversal Lamb wave.
Wherein the lamb wave irradiated from the lamb wave transmitting unit is a single mode lamb wave having a single frequency in the range of 180 to 220 kHz.
A first conversion step of receiving a Lamb wave from the Lamb wave receiving unit in the initial Lamb wave irradiation step and converting the Lamb wave into an electrical signal;
A time reversing step of receiving the Lamb wave first irradiated to the tibia from the Lamb wave receiving unit and converting the received Lamb wave into an electrical signal, receiving the electrical signal converted by the time reversing unit, and inverting the time;
A time reversing Lamb wave generating step of generating the Lamb waves of time reversal from the electrical signals obtained by time-inverting the Lamb wave generator in the time inverting unit;
A time inverted lamb wave irradiation step of irradiating the tibia with the time-reversed lamb wave generated by the lamb wave transmitter in the lamb wave generator;
A second conversion step of receiving the time reversal Lamb wave from the Lamb wave reception unit and converting the Lamb wave into the electrical signal in the time reversing Lamb wave irradiation step; And
And a calculation step of calculating a propagation speed of the lamb wave propagated along the cortical bone through the electrical signal converted by the calculation unit in the second conversion step,
Wherein,
A propagation speed calculation step of the signal processing unit detecting the electrical signal converted in the first conversion step and calculating the propagation speed of the lamb wave propagated along the cortical bone by the calculation unit; And
And a prediction step of predicting the bone density of the cortical bone using a correlation between the propagation velocity of the lamb wave propagated along the cortical bone calculated in the propagation speed calculation step and the bone density of the cortical bone,
Wherein the calculating step is a step of predicting a bone density of the cortical bone using a linear relationship between a propagation velocity value of the time reversed lamb wave propagated along the cortical bone and a bone density value of the cortical bone in proportion to and increasing in amount,
Wherein the propagation velocity is a propagation velocity of a first arriving signal (FAS) or a slow guided wave (SGW) that first arrives at the lamb wave receiving unit. Prediction method.
Wherein the lamb wave irradiated from the lamb wave transmitting unit in the initial lamb wave irradiating step is a single mode lamb wave having a single frequency in the range of 180 to 220 kHz.
The method of claim 1, further comprising: an output step of outputting a propagation velocity of a lamb wave propagated along the cortical bone calculated in the calculating step and a bone density prediction result of the cortical bone using the time reversing lamb wave. A Method for Predicting Bone Mineral Density of Cortical Bones Using Inverted.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150137644A KR101643104B1 (en) | 2015-09-30 | 2015-09-30 | Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150137644A KR101643104B1 (en) | 2015-09-30 | 2015-09-30 | Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves |
Publications (1)
Publication Number | Publication Date |
---|---|
KR101643104B1 true KR101643104B1 (en) | 2016-07-26 |
Family
ID=56681096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020150137644A KR101643104B1 (en) | 2015-09-30 | 2015-09-30 | Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR101643104B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050064936A (en) * | 2003-12-24 | 2005-06-29 | 학교법인 성균관대학 | Device and method for bone mineral density measurement by using lamb wave |
US20140180113A1 (en) * | 2011-10-17 | 2014-06-26 | Butterfly Network, Inc. | Transmissive imaging and related apparatus and methods |
-
2015
- 2015-09-30 KR KR1020150137644A patent/KR101643104B1/en active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050064936A (en) * | 2003-12-24 | 2005-06-29 | 학교법인 성균관대학 | Device and method for bone mineral density measurement by using lamb wave |
US20140180113A1 (en) * | 2011-10-17 | 2014-06-26 | Butterfly Network, Inc. | Transmissive imaging and related apparatus and methods |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102469990B (en) | Ultrasonic detection device having function of confirming application position, and method therefor | |
Rohde et al. | Influence of porosity, pore size, and cortical thickness on the propagation of ultrasonic waves guided through the femoral neck cortex: A simulation study | |
Moreau et al. | Measuring the wavenumber of guided modes in waveguides with linearly varying thickness | |
KR101412785B1 (en) | Method and apparatus for estimating bone mineral density using ultrasonic nonlinear parameter | |
KR20180037351A (en) | Apparatus and method for estimating bone structure using ultrasonic nonlinear parameter | |
Daugschies et al. | The preliminary evaluation of a 1 MHz ultrasound probe for measuring the elastic anisotropy of human cortical bone | |
KR101345870B1 (en) | Method for estimating bone mineral density using ultrasonic attenuation | |
KR101432871B1 (en) | Measuring method and device of bone density by using dispersion rate of ultrasonic phase velocity | |
KR102140538B1 (en) | Apparatus for estimating bone mineral density and bone structure using frequency dependence of ultrasonic backscatter coefficient | |
KR101637088B1 (en) | Method and apparatus for estimating bone mineral density using a time reversal acoustic focusing technique | |
KR101643104B1 (en) | Method and apparatus for estimating cortical bone mineral density using time-reversed lamb waves | |
KR101102784B1 (en) | Estimation method of bone mineral density | |
KR101840349B1 (en) | Apparatus and method for estimating bone mineral density using ultrasonic sum frequency component | |
KR102303922B1 (en) | Method for estimating bone mineral density and bone structure using ultrasonic attenuation coefficient and phase velocity | |
JPWO2008018612A1 (en) | Ultrasonic fracture treatment device, fracture treatment receiving device and fracture position inspection device | |
KR101306543B1 (en) | Method and apparatus for estimating bone mineral density of proximal femur using ultrasonic backscatter coefficient | |
KR101510525B1 (en) | Method for Estimating Bone Structure of Proximal Femur by Using Ultrasonic Attenuation and Backscatter Coefficients | |
Lee et al. | Relationships of the group velocity of the time-reversed Lamb wave with bone properties in cortical bone in vitro | |
KR101636151B1 (en) | Method and apparatus for estimating cortical bone thickness using time-reversed lamb waves | |
KR100548182B1 (en) | Device and Method for Bone Mineral Density Measurement by Using Broadband Ultrasonic Reflection | |
KR100581229B1 (en) | Method for Measuring the Density of Shinbone by Using Lamb Wave | |
JP2009183454A (en) | Ultrasonic inspection apparatus or ultrasonic irradiation position inspection method using frequency damping characteristic | |
KR101239583B1 (en) | A diagnostic device by ultrasonic reflection monitoring and a method thereof | |
US20140187954A1 (en) | Infant bone assessment | |
KR102364309B1 (en) | Method for estimating bone mineral density and bone structure using ultrasonic attenuation coefficient and backscatter coefficient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20190715 Year of fee payment: 4 |